BDBM12129 3-(Indol-2-yl)indazole 19::3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(2H-1,2,3-triazol-2-yl)-1H-indazole

SMILES C(N1CCCCC1)c1ccc2[nH]c(cc2c1)-c1n[nH]c2cc(ccc12)-n1nccn1

InChI Key InChIKey=NMDXBIIYGMMZCL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 12129   

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12129(3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(2H-1...)
Affinity DataIC50: 34nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12129(3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(2H-1...)
Affinity DataIC50: 480nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed