BDBM12134 2-methoxy-4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazol-6-yl}phenol::3-(Indol-2-yl)indazole 24

SMILES COc1cc(ccc1O)-c1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCCCC3)ccc2[nH]1

InChI Key InChIKey=CDMSQHCJYCHHAF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 12134   

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12134(2-methoxy-4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-...)
Affinity DataIC50: 0.25nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12134(2-methoxy-4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-...)
Affinity DataIC50: 310nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed