BDBM14011 (5S)-6-methyl-30-oxo-19-oxa-2,6,10,12-tetraazahexacyclo[18.6.2.1^{2,5}.1^{14,18}.0^{8,12}.0^{23,27}]triaconta-1(27),8,10,14(29),15,17,20(28),21,23,25-decaene-17-carbonitrile::CHEMBL497048::Macrocyclic 3-Aminopyrrolidinone analog 51

SMILES CN1Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(N5CC[C@H]1C5=O)c4c3)c2

InChI Key InChIKey=LLIPALBHLJKSHD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14011   

LigandPNGBDBM14011(CHEMBL497048 | (5S)-6-methyl-30-oxo-19-oxa-2,6,10,...)
Affinity DataIC50: 4.90nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14011(CHEMBL497048 | (5S)-6-methyl-30-oxo-19-oxa-2,6,10,...)
Affinity DataIC50: 2.20E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14011(CHEMBL497048 | (5S)-6-methyl-30-oxo-19-oxa-2,6,10,...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed