BDBM50311930 CHEMBL1076468::N-(3-(1-(6-(2-(diethylamino)ethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(trifluoromethyl)benzamide

SMILES CCN(CC)CCNc1cc(ncn1)-n1c(Nc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)nc2ccccc12

InChI Key InChIKey=REDBMKRPRFVCHI-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50311930   

TargetTyrosine-protein kinase Lck(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311930(N-(3-(1-(6-(2-(diethylamino)ethylamino)pyrimidin-4...)
Affinity DataIC50: 111nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311930(N-(3-(1-(6-(2-(diethylamino)ethylamino)pyrimidin-4...)
Affinity DataIC50: 378nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311930(N-(3-(1-(6-(2-(diethylamino)ethylamino)pyrimidin-4...)
Affinity DataIC50: 398nMAssay Description:Inhibition of Tel-fused SRC expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311930(N-(3-(1-(6-(2-(diethylamino)ethylamino)pyrimidin-4...)
Affinity DataIC50: 418nMAssay Description:Inhibition of Tel-fused LCK expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311930(N-(3-(1-(6-(2-(diethylamino)ethylamino)pyrimidin-4...)
Affinity DataIC50: 642nMAssay Description:Inhibition of Tel-fused LYN expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311930(N-(3-(1-(6-(2-(diethylamino)ethylamino)pyrimidin-4...)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of Tel-fused InsR expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311930(N-(3-(1-(6-(2-(diethylamino)ethylamino)pyrimidin-4...)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of Tel-fused KDR expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311930(N-(3-(1-(6-(2-(diethylamino)ethylamino)pyrimidin-4...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed