BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 88531 Oc1cccc2c(OC(=O)c3ccccc3)cccc12 InChI=1S/C17H12O3/c18-15-10-4-9-14-13(15)8-5-11-16(14)20-17(19)12-6-2-1-3-7-12/h1-11,18H TWYZJDASIMIAPK-UHFFFAOYSA-N 47396 (5-hydroxynaphthalen-1-yl) benzoate::(5-oxidanylnaphthalen-1-yl) benzoate::Benzoic acid 5-hydroxy-naphthalen-1-yl ester::MLS000030944::SMR000009914::benzoic acid (5-hydroxy-1-naphthalenyl) ester::benzoic acid (5-hydroxy-1-naphthyl) ester::cid_646429 Tyrosine-protein kinase JAK2 Homo sapiens 6512 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47396&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 646429 252627708 ZINC00271727 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88532 CCCn1c(CN(C)Cc2ccccc2)nc2n(C)c(=O)n(C)c(=O)c12 InChI=1S/C19H25N5O2/c1-5-11-24-15(13-21(2)12-14-9-7-6-8-10-14)20-17-16(24)18(25)23(4)19(26)22(17)3/h6-10H,5,11-13H2,1-4H3 YXUWZBOASXLGTC-UHFFFAOYSA-N 47397 1,3-dimethyl-8-[[methyl-(phenylmethyl)amino]methyl]-7-propyl-purine-2,6-dione::1,3-dimethyl-8-[[methyl-(phenylmethyl)amino]methyl]-7-propylpurine-2,6-dione::8-[(Benzyl-methyl-amino)-methyl]-1,3-dimethyl-7-propyl-3,7-dihydro-purine-2,6-dione::8-[[benzyl(methyl)amino]methyl]-1,3-dimethyl-7-propyl-xanthine::8-[[benzyl(methyl)amino]methyl]-1,3-dimethyl-7-propylpurine-2,6-dione::MLS000034933::SMR000014445::cid_651947 Tyrosine-protein kinase JAK2 Homo sapiens 8174 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47397&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 651947 252627709 ZINC02597758 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88533 Oc1ccc(\C=C(/C#N)C(=O)NCCCc2ccccc2)cc1O InChI=1S/C19H18N2O3/c20-13-16(11-15-8-9-17(22)18(23)12-15)19(24)21-10-4-7-14-5-2-1-3-6-14/h1-3,5-6,8-9,11-12,22-23H,4,7,10H2,(H,21,24)/b16-11+ GSQOBTOAOGXIFL-LFIBNONCSA-N 4303 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide::(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide::(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)acrylamide::(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide::(E)-3-[3,4-bis(oxidanyl)phenyl]-2-cyano-N-(3-phenylpropyl)prop-2-enamide::CHEMBL53898::MLS000069704::SMR000058519::TYRPHOSTIN AG 555::Tyrphostin deriv. 46::cid_5328770 Tyrosine-protein kinase JAK2 Homo sapiens 6007 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4303&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5328770 8033980 CHEMBL53898 ZINC02557957 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88534 Nc1nc(N)c2nc(c(N)nc2n1)-c1ccccc1 InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19) FNYLWPVRPXGIIP-UHFFFAOYSA-N 6644 6‐phenylpteridine‐2,4,7‐triamine (5)::6-phenylpteridine-2,4,7-triamine::Pteridine deriv. 11::TRIAMTERENE Tyrosine-protein kinase JAK2 Homo sapiens 4613 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6644&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search DX2 3JQ7 5546 8036221 DB00384 4329 ZINC00120286 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88535 [O-][N+]1=c2ccc(Nc3ccccc3)cc2=NC11CCCCC1 InChI=1S/C18H19N3O/c22-21-17-10-9-15(19-14-7-3-1-4-8-14)13-16(17)20-18(21)11-5-2-6-12-18/h1,3-4,7-10,13,19H,2,5-6,11-12H2 QEKYDTGXFOVMRB-UHFFFAOYSA-N 34573 (1-oxidospiro[benzimidazol-1-ium-2,1'-cyclohexane]-5-yl)-phenyl-amine::1-oxidanidyl-N-phenyl-spiro[benzimidazol-1-ium-2,1'-cyclohexane]-5-amine::1-oxido-N-phenyl-5-spiro[benzimidazol-1-ium-2,1'-cyclohexane]amine::1-oxido-N-phenylspiro[benzimidazol-1-ium-2,1'-cyclohexane]-5-amine::MLS000079671::SMR000035951::cid_657546 Tyrosine-protein kinase JAK2 Homo sapiens 5197 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34573&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 657546 252617226 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88536 CCCc1nc2ccccc2c(=O)n1N=Cc1ccc(O)c(O)c1 InChI=1S/C18H17N3O3/c1-2-5-17-20-14-7-4-3-6-13(14)18(24)21(17)19-11-12-8-9-15(22)16(23)10-12/h3-4,6-11,22-23H,2,5H2,1H3 ZAGYRXCHJNKGDS-UHFFFAOYSA-N 32041 3-[[(Z)-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]amino]-2-propyl-quinazolin-4-one::3-[[(Z)-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]amino]-2-propyl-4-quinazolinone::3-[[(Z)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]amino]-2-propylquinazolin-4-one::3-[[(Z)-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]amino]-2-propyl-quinazolin-4-one::MLS000039021::SMR000037671::cid_5389225 Tyrosine-protein kinase JAK2 Homo sapiens 3619 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32041&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5389225 252615495 ZINC13127817 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88537 COc1cc2CCn3c(cc(nc3=O)N3CCCc4ccccc34)-c2cc1OC InChI=1S/C23H23N3O3/c1-28-20-12-16-9-11-26-19(17(16)13-21(20)29-2)14-22(24-23(26)27)25-10-5-7-15-6-3-4-8-18(15)25/h3-4,6,8,12-14H,5,7,9-11H2,1-2H3 UYPMUBFBYLWPON-UHFFFAOYSA-N 31059 2-(3,4-dihydro-2H-quinolin-1-yl)-9,10-dimethoxy-6,7-dihydropyrimid[6,1-a]isoquinolin-4-one::2-(3,4-dihydro-2H-quinolin-1-yl)-9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one::MLS000082045::SMR000044807::cid_663831 Tyrosine-protein kinase JAK2 Homo sapiens 35640 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31059&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 663831 252615310 ZINC04302138 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88538 CC(C)C[C@H](NC(=O)OC(C)(C)C)c1nnc(o1)S(=O)(=O)Cc1ccccc1C InChI=1S/C20H29N3O5S/c1-13(2)11-16(21-18(24)28-20(4,5)6)17-22-23-19(27-17)29(25,26)12-15-10-8-7-9-14(15)3/h7-10,13,16H,11-12H2,1-6H3,(H,21,24)/t16-/m0/s1 YHEGOWAWRJPXJC-INIZCTEOSA-N 36928 MLS000083238::N-[(1S)-3-methyl-1-[5-(2-methylbenzyl)sulfonyl-1,3,4-oxadiazol-2-yl]butyl]carbamic acid tert-butyl ester::N-[(1S)-3-methyl-1-[5-[(2-methylphenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]butyl]carbamic acid tert-butyl ester::SMR000044673::cid_663900::tert-butyl N-[(1S)-3-methyl-1-[5-[(2-methylphenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]butyl]carbamate Tyrosine-protein kinase JAK2 Homo sapiens 1676 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36928&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 663900 252617900 ZINC02415533 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88539 CCC(C)[C@@H](NC(=O)OC(C)(C)C)c1nnc(o1)S(=O)(=O)Cc1cccc(C)c1 InChI=1S/C20H29N3O5S/c1-7-14(3)16(21-18(24)28-20(4,5)6)17-22-23-19(27-17)29(25,26)12-15-10-8-9-13(2)11-15/h8-11,14,16H,7,12H2,1-6H3,(H,21,24)/t14?,16-/m1/s1 ZIUUJQFALWMFMS-BZSJEYESSA-N 33524 MLS000041935::N-[(1R)-2-methyl-1-[5-(3-methylbenzyl)sulfonyl-1,3,4-oxadiazol-2-yl]butyl]carbamic acid tert-butyl ester::N-[(1R)-2-methyl-1-[5-[(3-methylphenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]butyl]carbamic acid tert-butyl ester::SMR000046674::cid_665480::tert-butyl N-[(1R)-2-methyl-1-[5-[(3-methylphenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]butyl]carbamate Tyrosine-protein kinase JAK2 Homo sapiens 4670 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33524&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 665480 252616431 ZINC04295716 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88540 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)c1nnc(o1)S(=O)(=O)Cc1cccc(F)c1 InChI=1S/C22H24FN3O5S/c1-22(2,3)31-20(27)24-18(13-15-8-5-4-6-9-15)19-25-26-21(30-19)32(28,29)14-16-10-7-11-17(23)12-16/h4-12,18H,13-14H2,1-3H3,(H,24,27)/t18-/m0/s1 VCSNQZGUMMNBJW-SFHVURJKSA-N 36948 MLS000041934::N-[(1S)-1-[5-(3-fluorobenzyl)sulfonyl-1,3,4-oxadiazol-2-yl]-2-phenyl-ethyl]carbamic acid tert-butyl ester::N-[(1S)-1-[5-[(3-fluorophenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]-2-phenylethyl]carbamic acid tert-butyl ester::SMR000046662::cid_665561::tert-butyl N-[(1S)-1-[5-[(3-fluorophenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]-2-phenyl-ethyl]carbamate::tert-butyl N-[(1S)-1-[5-[(3-fluorophenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]-2-phenylethyl]carbamate Tyrosine-protein kinase JAK2 Homo sapiens 3741 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36948&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 665561 252617920 ZINC02398804 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88541 Clc1ccc(cc1)-n1nnnc1Sc1ncnc2sccc12 InChI=1S/C13H7ClN6S2/c14-8-1-3-9(4-2-8)20-13(17-18-19-20)22-12-10-5-6-21-11(10)15-7-16-12/h1-7H FEXPLGPKTJVGOT-UHFFFAOYSA-N 31061 4-[1-(4-chlorophenyl)tetrazol-5-yl]sulfanylthieno[2,3-d]pyrimidine::4-[[1-(4-chlorophenyl)-1,2,3,4-tetrazol-5-yl]sulfanyl]thieno[2,3-d]pyrimidine::4-[[1-(4-chlorophenyl)-5-tetrazolyl]thio]thieno[2,3-d]pyrimidine::4-[[1-(4-chlorophenyl)tetrazol-5-yl]thio]thieno[2,3-d]pyrimidine::MLS000058692::SMR000066808::cid_2112599 Tyrosine-protein kinase JAK2 Homo sapiens 2906 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31061&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2112599 252615312 ZINC02649462 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88542 CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccco1 InChI=1S/C10H7F3N2O3S/c1-19(16,17)9-14-6(7-3-2-4-18-7)5-8(15-9)10(11,12)13/h2-5H,1H3 DYLWYHLPRCPPQD-UHFFFAOYSA-N 31064 4-(2-furanyl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine::4-(2-furyl)-2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidine::4-(2-furyl)-2-mesyl-6-(trifluoromethyl)pyrimidine::4-(furan-2-yl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine::MLS000044646::SMR000022590::cid_3237865 Tyrosine-protein kinase JAK2 Homo sapiens 2283 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31064&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 3237865 252615315 ZINC03896297 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88543 C#CCSc1nsc(SCC#C)c1C#N InChI=1S/C10H6N2S3/c1-3-5-13-9-8(7-11)10(15-12-9)14-6-4-2/h1-2H,5-6H2 XWYJKRZSAPDODU-UHFFFAOYSA-N 47398 3,5-bis(prop-2-ynylsulfanyl)-1,2-thiazole-4-carbonitrile::3,5-bis(prop-2-ynylthio)-4-isothiazolecarbonitrile::3,5-bis(prop-2-ynylthio)isothiazole-4-carbonitrile::3,5-bis(propargylthio)isothiazole-4-carbonitrile::MLS000087783::SMR000024003::cid_2803060 Tyrosine-protein kinase JAK2 Homo sapiens 2833 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47398&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2803060 252627710 ZINC02163375 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88544 Clc1c(sc2ccccc12)C(=O)NC1CS(=O)(=O)C=C1 InChI=1S/C13H10ClNO3S2/c14-11-9-3-1-2-4-10(9)19-12(11)13(16)15-8-5-6-20(17,18)7-8/h1-6,8H,7H2,(H,15,16) QFAZQWQCOSKELB-UHFFFAOYSA-N 47399 3-chloro-N-(1,1-diketo-2,3-dihydrothiophen-3-yl)benzothiophene-2-carboxamide::3-chloro-N-(1,1-dioxido-2,3-dihydro-3-thienyl)-1-benzothiophene-2-carboxamide::3-chloro-N-(1,1-dioxo-2,3-dihydrothiophen-3-yl)-1-benzothiophene-2-carboxamide::MLS000066386::N-[1,1-bis(oxidanylidene)-2,3-dihydrothiophen-3-yl]-3-chloranyl-1-benzothiophene-2-carboxamide::SMR000081313::cid_2973977 Tyrosine-protein kinase JAK2 Homo sapiens 13770 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47399&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2973977 252627711 ZINC01060489 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88545 Cc1cccc(OCC(=O)Nc2cc(C)ccc2O)c1 InChI=1S/C16H17NO3/c1-11-4-3-5-13(8-11)20-10-16(19)17-14-9-12(2)6-7-15(14)18/h3-9,18H,10H2,1-2H3,(H,17,19) QRSGMNRMRKEVOZ-UHFFFAOYSA-N 37769 MLS000100112::N-(2-hydroxy-5-methyl-phenyl)-2-(3-methylphenoxy)acetamide::N-(2-hydroxy-5-methylphenyl)-2-(3-methylphenoxy)acetamide::N-(5-methyl-2-oxidanyl-phenyl)-2-(3-methylphenoxy)ethanamide::SMR000081890::cid_2233047 Tyrosine-protein kinase JAK2 Homo sapiens >40000 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37769&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2233047 252618732 ZINC02880858 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88546 COc1ccc(cc1)-n1nnnc1SCC(=O)c1ccc(O)c(O)c1 InChI=1S/C16H14N4O4S/c1-24-12-5-3-11(4-6-12)20-16(17-18-19-20)25-9-15(23)10-2-7-13(21)14(22)8-10/h2-8,21-22H,9H2,1H3 GDWOAVFPULCMCY-UHFFFAOYSA-N 50237956 1-(3,4-dihydroxyphenyl)-2-(1-(4-methoxyphenyl)-1H-tetrazol-5-ylthio)ethanone::CHEMBL254255::cid_1515366 Tyrosine-protein kinase JAK2 Homo sapiens 3336 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50237956&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1515366 104056477 CHEMBL254255 ZINC01437546 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88547 COc1ccc(OC)c(NS(=O)(=O)c2ccc(SC)cc2)c1 InChI=1S/C15H17NO4S2/c1-19-11-4-9-15(20-2)14(10-11)16-22(17,18)13-7-5-12(21-3)6-8-13/h4-10,16H,1-3H3 KHKINSFQHMMKAG-UHFFFAOYSA-N 47400 MLS000065286::N-(2,5-dimethoxyphenyl)-4-(methylthio)benzenesulfonamide::N-(2,5-dimethoxyphenyl)-4-methylsulfanyl-benzenesulfonamide::N-(2,5-dimethoxyphenyl)-4-methylsulfanylbenzenesulfonamide::SMR000078938::cid_966872 Tyrosine-protein kinase JAK2 Homo sapiens 12440 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47400&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 966872 252627712 ZINC00581193 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88548 COc1ccc(Nc2ccc3=[N+]([O-])C4(CCCCC4)N=c3c2)cc1 InChI=1S/C19H21N3O2/c1-24-16-8-5-14(6-9-16)20-15-7-10-18-17(13-15)21-19(22(18)23)11-3-2-4-12-19/h5-10,13,20H,2-4,11-12H2,1H3 HWFYFSNVLANFJX-UHFFFAOYSA-N 34637 (4-methoxyphenyl)-(1-oxidospiro[benzimidazol-1-ium-2,1'-cyclohexane]-5-yl)amine::MLS000105165::N-(4-methoxyphenyl)-1-oxidanidyl-spiro[benzimidazol-1-ium-2,1'-cyclohexane]-5-amine::N-(4-methoxyphenyl)-1-oxido-5-spiro[benzimidazol-1-ium-2,1'-cyclohexane]amine::N-(4-methoxyphenyl)-1-oxidospiro[benzimidazol-1-ium-2,1'-cyclohexane]-5-amine::SMR000055094::cid_791069 Tyrosine-protein kinase JAK2 Homo sapiens 1711 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34637&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 791069 252617287 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88549 Cc1oc2c(O)c(O)ccc2c(=O)c1-c1cnn(c1)-c1ccccc1 InChI=1S/C19H14N2O4/c1-11-16(12-9-20-21(10-12)13-5-3-2-4-6-13)17(23)14-7-8-15(22)18(24)19(14)25-11/h2-10,22,24H,1H3 ZVWHFHQBQHDONN-UHFFFAOYSA-N 47401 2-methyl-7,8-bis(oxidanyl)-3-(1-phenylpyrazol-4-yl)chromen-4-one::7,8-dihydroxy-2-methyl-3-(1-phenyl-4-pyrazolyl)-1-benzopyran-4-one::7,8-dihydroxy-2-methyl-3-(1-phenylpyrazol-4-yl)chromen-4-one::7,8-dihydroxy-2-methyl-3-(1-phenylpyrazol-4-yl)chromone::MLS000111828::SMR000107747::cid_5310850 Tyrosine-protein kinase JAK2 Homo sapiens 2966 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47401&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5310850 252627713 ZINC06556404 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88550 OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ncc(=O)[nH]c1=O InChI=1S/C8H11N3O6/c12-2-3-5(14)6(15)7(17-3)11-8(16)10-4(13)1-9-11/h1,3,5-7,12,14-15H,2H2,(H,10,13,16)/t3-,5-,6-,7-/m1/s1 WYXSYVWAUAUWLD-SHUUEZRQSA-N 47402 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-1,2,4-triazine-3,5-dione::2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione::2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-1,2,4-triazine-3,5-quinone::2-[(2R,3R,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione::6-AZAURIDINE::MLS000028524::SMR000058273::cid_5901 Tyrosine-protein kinase JAK2 Homo sapiens 6798 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47402&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5901 252627714 35668 ZINC01078595 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88551 CN(C)C(=S)SSC(=S)N(C)C InChI=1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3 KUAZQDVKQLNFPE-UHFFFAOYSA-N 43362 MLS000069752::N,N-dimethylcarbamodithioic acid (dimethylthiocarbamoylthio) ester::N,N-dimethylcarbamodithioic acid [[dimethylamino(sulfanylidene)methyl]thio] ester::SMR000059023::TETRAMETHYLTHIURAM DISULFIDE::cid_5455::dimethylcarbamothioylsulfanyl N,N-dimethylcarbamodithioate Tyrosine-protein kinase JAK2 Homo sapiens 223 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43362&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5455 252624043 9495 C15496 ZINC01532176 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88552 FC(F)(F)C(=O)Nc1cccc2c3ccccc3[nH]c12 InChI=1S/C14H9F3N2O/c15-14(16,17)13(20)19-11-7-3-5-9-8-4-1-2-6-10(8)18-12(9)11/h1-7,18H,(H,19,20) ZZVSTWVVMYTUJI-UHFFFAOYSA-N 47403 MLS000550559::N-(9H-carbazol-1-yl)-2,2,2-trifluoro-acetamide::N-(9H-carbazol-1-yl)-2,2,2-trifluoroacetamide::N-(9H-carbazol-1-yl)-2,2,2-tris(fluoranyl)ethanamide::SMR000113934::cid_1719380 Tyrosine-protein kinase JAK2 Homo sapiens 13710 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47403&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1719380 252627715 ZINC02054119 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88553 CCCOc1ccc(cc1)C(=O)C(CN1CCOCC1)c1ccccc1 InChI=1S/C22H27NO3/c1-2-14-26-20-10-8-19(9-11-20)22(24)21(18-6-4-3-5-7-18)17-23-12-15-25-16-13-23/h3-11,21H,2,12-17H2,1H3 WVAHEPZRTLCPMI-UHFFFAOYSA-N 47404 3-(4-morpholinyl)-2-phenyl-1-(4-propoxyphenyl)-1-propanone::3-Morpholin-4-yl-2-phenyl-1-(4-propoxy-phenyl)-propan-1-one::3-morpholin-4-yl-2-phenyl-1-(4-propoxyphenyl)propan-1-one::3-morpholino-2-phenyl-1-(4-propoxyphenyl)propan-1-one::MLS000121316::SMR000118765::cid_3102106 Tyrosine-protein kinase JAK2 Homo sapiens 2460 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47404&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 3102106 252627716 ZINC19313985 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88554 Cc1nn(Cc2ccc(Cl)cc2Cl)c(C)c1NC(=O)CCl InChI=1S/C14H14Cl3N3O/c1-8-14(18-13(21)6-15)9(2)20(19-8)7-10-3-4-11(16)5-12(10)17/h3-5H,6-7H2,1-2H3,(H,18,21) FZASWUJFYQIWBM-UHFFFAOYSA-N 47405 2-chloranyl-N-[1-[(2,4-dichlorophenyl)methyl]-3,5-dimethyl-pyrazol-4-yl]ethanamide::2-chloro-N-[1-(2,4-dichlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl]acetamide::2-chloro-N-[1-(2,4-dichlorobenzyl)-3,5-dimethyl-pyrazol-4-yl]acetamide::2-chloro-N-[1-[(2,4-dichlorophenyl)methyl]-3,5-dimethyl-4-pyrazolyl]acetamide::2-chloro-N-[1-[(2,4-dichlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]acetamide::MLS000546739::SMR000115075::cid_844575 Tyrosine-protein kinase JAK2 Homo sapiens 11410 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47405&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 844575 252627717 ZINC00375912 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88555 COC1(OC)C(\C=C/c2ccc(Cl)cc2)C(C#N)(C#N)C1(OC)OC InChI=1S/C18H19ClN2O4/c1-22-17(23-2)15(10-7-13-5-8-14(19)9-6-13)16(11-20,12-21)18(17,24-3)25-4/h5-10,15H,1-4H3/b10-7- WTXBTYXCVPLYNX-YFHOEESVSA-N 47406 4-[(Z)-2-(4-chlorophenyl)ethenyl]-2,2,3,3-tetramethoxy-cyclobutane-1,1-dicarbonitrile::4-[(Z)-2-(4-chlorophenyl)ethenyl]-2,2,3,3-tetramethoxycyclobutane-1,1-dicarbonitrile::4-[(Z)-2-(4-chlorophenyl)vinyl]-2,2,3,3-tetramethoxy-cyclobutane-1,1-dicarbonitrile::MLS000549191::SMR000040500::cid_6018667 Tyrosine-protein kinase JAK2 Homo sapiens 7832 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47406&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 4135984 252627718 ZINC13122221 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88556 CCOc1ccc(cc1)C(=O)C(CN1CCOCC1)c1ccccc1 InChI=1S/C21H25NO3/c1-2-25-19-10-8-18(9-11-19)21(23)20(17-6-4-3-5-7-17)16-22-12-14-24-15-13-22/h3-11,20H,2,12-16H2,1H3 USVOEAYFZSWIIR-UHFFFAOYSA-N 47407 1-(4-Ethoxy-phenyl)-3-morpholin-4-yl-2-phenyl-propan-1-one::1-(4-ethoxyphenyl)-3-(4-morpholinyl)-2-phenyl-1-propanone;hydrochloride::1-(4-ethoxyphenyl)-3-morpholin-4-yl-2-phenyl-propan-1-one;hydrochloride::1-(4-ethoxyphenyl)-3-morpholin-4-yl-2-phenylpropan-1-one;hydrochloride::3-morpholino-2-phenyl-1-p-phenetyl-propan-1-one;hydrochloride::MLS000552437::SMR000145952::cid_9550019 Tyrosine-protein kinase JAK2 Homo sapiens 2404 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47407&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 567724 252627719 ZINC20840614 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88557 Cc1nc(c(Br)n1CC(=O)c1ccc2ccccc2c1)[N+]([O-])=O InChI=1S/C16H12BrN3O3/c1-10-18-16(20(22)23)15(17)19(10)9-14(21)13-7-6-11-4-2-3-5-12(11)8-13/h2-8H,9H2,1H3 FKJFPVNMXOYFQM-UHFFFAOYSA-N 47408 2-(5-bromanyl-2-methyl-4-nitro-imidazol-1-yl)-1-naphthalen-2-yl-ethanone::2-(5-bromo-2-methyl-4-nitro-1-imidazolyl)-1-(2-naphthalenyl)ethanone::2-(5-bromo-2-methyl-4-nitro-imidazol-1-yl)-1-(2-naphthyl)ethanone::2-(5-bromo-2-methyl-4-nitroimidazol-1-yl)-1-naphthalen-2-ylethanone::MLS000520163::SMR000130576::cid_9550892 Tyrosine-protein kinase JAK2 Homo sapiens 3676 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47408&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 9550892 252627720 ZINC04876033 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88558 CC(C)C1C(C#N)C(=N)Oc2[nH]nc(c12)-c1ccc2ccccc2c1 InChI=1S/C20H18N4O/c1-11(2)16-15(10-21)19(22)25-20-17(16)18(23-24-20)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11,15-16,22H,1-2H3,(H,23,24) OVCCWCBAMIPGIG-UHFFFAOYSA-N 47409 6-amino-3-(2-naphthalenyl)-4-propan-2-yl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::6-amino-3-naphthalen-2-yl-4-propan-2-yl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::6-amino-4-isopropyl-3-(2-naphthyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::6-azanyl-3-naphthalen-2-yl-4-propan-2-yl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::MLS000519074::SMR000129493::cid_4191109 Tyrosine-protein kinase JAK2 Homo sapiens 3565 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47409&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 91896719 252627721 ZINC13139111 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88559 COc1ccccc1-c1nnc(Sc2nc(nn2C)[N+]([O-])=O)o1 InChI=1S/C12H10N6O4S/c1-17-11(13-10(16-17)18(19)20)23-12-15-14-9(22-12)7-5-3-4-6-8(7)21-2/h3-6H,1-2H3 KIXAQAHEYFGFQB-UHFFFAOYSA-N 47410 2-(2-methoxyphenyl)-5-[(1-methyl-3-nitro-1H-1,2,4-triazol-5-yl)thio]-1,3,4-oxadiazole::2-(2-methoxyphenyl)-5-[(2-methyl-5-nitro-1,2,4-triazol-3-yl)sulfanyl]-1,3,4-oxadiazole::2-(2-methoxyphenyl)-5-[(2-methyl-5-nitro-1,2,4-triazol-3-yl)thio]-1,3,4-oxadiazole::MLS000537812::SMR000144049::cid_2205572 Tyrosine-protein kinase JAK2 Homo sapiens 4653 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47410&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2205572 252627722 ZINC02851874 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88560 Cc1ccccc1CS(=O)(=O)c1nnc(o1)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C InChI=1S/C23H27N3O5S/c1-16-10-8-9-13-18(16)15-32(28,29)22-26-25-20(30-22)19(14-17-11-6-5-7-12-17)24-21(27)31-23(2,3)4/h5-13,19H,14-15H2,1-4H3,(H,24,27)/t19-/m0/s1 OPZXUEIGPNYNBQ-IBGZPJMESA-N 47411 MLS000558488::N-[(1S)-1-[5-(2-methylbenzyl)sulfonyl-1,3,4-oxadiazol-2-yl]-2-phenyl-ethyl]carbamic acid tert-butyl ester::N-[(1S)-1-[5-[(2-methylphenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]-2-phenylethyl]carbamic acid tert-butyl ester::SMR000149004::[(S)-2-Phenyl-1-(5-o-tolylmethanesulfonyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamic acid tert-butyl ester::cid_9551645::tert-butyl N-[(1S)-1-[5-[(2-methylphenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]-2-phenyl-ethyl]carbamate::tert-butyl N-[(1S)-1-[5-[(2-methylphenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]-2-phenylethyl]carbamate Tyrosine-protein kinase JAK2 Homo sapiens 5328 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47411&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 9551645 252627723 ZINC08690156 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88561 Cc1cccc(CS(=O)(=O)c2nnc(o2)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)c1 InChI=1S/C23H27N3O5S/c1-16-9-8-12-18(13-16)15-32(28,29)22-26-25-20(30-22)19(14-17-10-6-5-7-11-17)24-21(27)31-23(2,3)4/h5-13,19H,14-15H2,1-4H3,(H,24,27)/t19-/m0/s1 PLKLULXRWFMWEX-IBGZPJMESA-N 47412 MLS000558489::N-[(1S)-1-[5-(3-methylbenzyl)sulfonyl-1,3,4-oxadiazol-2-yl]-2-phenyl-ethyl]carbamic acid tert-butyl ester::N-[(1S)-1-[5-[(3-methylphenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]-2-phenylethyl]carbamic acid tert-butyl ester::SMR000149005::[(S)-2-Phenyl-1-(5-m-tolylmethanesulfonyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamic acid tert-butyl ester::cid_2010180::tert-butyl N-[(1S)-1-[5-[(3-methylphenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]-2-phenyl-ethyl]carbamate::tert-butyl N-[(1S)-1-[5-[(3-methylphenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]-2-phenylethyl]carbamate Tyrosine-protein kinase JAK2 Homo sapiens 3644 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47412&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2010180 252627724 ZINC02412930 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88562 COc1ccc(cc1OC)C1=Nn2c(SC1)nnc2C1CCCCC1 InChI=1S/C18H22N4O2S/c1-23-15-9-8-13(10-16(15)24-2)14-11-25-18-20-19-17(22(18)21-14)12-6-4-3-5-7-12/h8-10,12H,3-7,11H2,1-2H3 GZKQZDCBXDRWEG-UHFFFAOYSA-N 47413 3-Cyclohexyl-6-(3,4-dimethoxy-phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::3-cyclohexyl-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::MLS000557010::SMR000148127::cid_3523871 Tyrosine-protein kinase JAK2 Homo sapiens 7519 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47413&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 3523871 252627725 ZINC06733530 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88563 Cc1cc(SCC(=O)NN=Cc2ccc(O)c(O)c2)c(C)cc1Br InChI=1S/C17H17BrN2O3S/c1-10-6-16(11(2)5-13(10)18)24-9-17(23)20-19-8-12-3-4-14(21)15(22)7-12/h3-8,21-22H,9H2,1-2H3,(H,20,23) WKTNKPAFSYJGSF-UHFFFAOYSA-N 47414 2-(4-bromanyl-2,5-dimethyl-phenyl)sulfanyl-N'-[(Z)-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]ethanehydrazide::2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N'-[(Z)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]acetohydrazide::2-[(4-bromo-2,5-dimethyl-phenyl)thio]-N'-[(Z)-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]acetohydrazide::2-[(4-bromo-2,5-dimethylphenyl)thio]-N'-[(Z)-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]acetohydrazide::MLS000570066::SMR000150086::cid_9552029 Tyrosine-protein kinase JAK2 Homo sapiens 10670 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47414&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 9552029 252627726 ZINC13110666 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88564 COc1cccc(C=NNC(=O)c2[nH]c(C)c(C(=O)NN=Cc3cccc(OC)c3O)c2C)c1O InChI=1S/C24H25N5O6/c1-13-19(23(32)28-25-11-15-7-5-9-17(34-3)21(15)30)14(2)27-20(13)24(33)29-26-12-16-8-6-10-18(35-4)22(16)31/h5-12,27,30-31H,1-4H3,(H,28,32)(H,29,33) VOEWPZDGLNIHGI-UHFFFAOYSA-N 32829 2-N',4-N'-bis[(E)-(5-methoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-3,5-dimethyl-1H-pyrrole-2,4-dicarbohydrazide::MLS000546134::N'~2~,N'~4~-bis(2-hydroxy-3-methoxybenzylidene)-3,5-dimethyl-1H-pyrrole-2,4-dicarbohydrazide::N2',N4'-bis[(E)-(5-methoxy-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]-3,5-dimethyl-1H-pyrrole-2,4-dicarbohydrazide::N2',N4'-bis[(E)-(5-methoxy-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-3,5-dimethyl-1H-pyrrole-2,4-dicarbohydrazide::N2',N4'-bis[(E)-(6-keto-5-methoxy-cyclohexa-2,4-dien-1-ylidene)methyl]-3,5-dimethyl-1H-pyrrole-2,4-dicarbohydrazide::SMR000162187::cid_11948786 Tyrosine-protein kinase JAK2 Homo sapiens 6662 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32829&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 11948786 252615965 ZINC02090057 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88565 CCCn1c(CC)nc(c1S(=O)(=O)c1ccccc1)[N+]([O-])=O InChI=1S/C14H17N3O4S/c1-3-10-16-12(4-2)15-13(17(18)19)14(16)22(20,21)11-8-6-5-7-9-11/h5-9H,3-4,10H2,1-2H3 OOPQTTHZIVMBFO-UHFFFAOYSA-N 47415 2-ethyl-4-nitro-5-(phenylsulfonyl)-1-propyl-1H-imidazole::2-ethyl-4-nitro-5-(phenylsulfonyl)-1-propyl-imidazole::5-(benzenesulfonyl)-2-ethyl-4-nitro-1-propylimidazole::5-besyl-2-ethyl-4-nitro-1-propyl-imidazole::MLS000545864::SMR000164045::cid_901979 Tyrosine-protein kinase JAK2 Homo sapiens 5896 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47415&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 901979 252627727 ZINC00481353 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88566 COc1ccc(N2CCc3c2c2cc(OC)cc(OC)c2nc3C)c(OC)c1 InChI=1S/C22H24N2O4/c1-13-16-8-9-24(18-7-6-14(25-2)11-19(18)27-4)22(16)17-10-15(26-3)12-20(28-5)21(17)23-13/h6-7,10-12H,8-9H2,1-5H3 MSELVEFUVDXEPF-UHFFFAOYSA-N 47416 1-(2,4-dimethoxyphenyl)-6,8-dimethoxy-4-methyl-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline::1-(2,4-dimethoxyphenyl)-6,8-dimethoxy-4-methyl-2,3-dihydropyrrolo[3,2-c]quinoline::MLS000547414::SMR000180313::cid_4555838 Tyrosine-protein kinase JAK2 Homo sapiens 8322 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47416&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 4555838 252627728 ZINC04050986 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88567 Clc1ccccc1C(=O)OCn1ncc(Cl)c(Cl)c1=O InChI=1S/C12H7Cl3N2O3/c13-8-4-2-1-3-7(8)12(19)20-6-17-11(18)10(15)9(14)5-16-17/h1-5H,6H2 XUUFIOHTEHAJQL-UHFFFAOYSA-N 41607 (4,5-dichloro-6-oxopyridazin-1-yl)methyl 2-chlorobenzoate::2-chlorobenzoic acid (4,5-dichloro-6-keto-pyridazin-1-yl)methyl ester::2-chlorobenzoic acid (4,5-dichloro-6-oxo-1-pyridazinyl)methyl ester::MLS000546962::SMR000180160::[4,5-bis(chloranyl)-6-oxidanylidene-pyridazin-1-yl]methyl 2-chloranylbenzoate::[4,5-dichloro-6-oxo-1(6H)-pyridazinyl]methyl 2-chlorobenzenecarboxylate::cid_1474461 Tyrosine-protein kinase JAK2 Homo sapiens 1199 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41607&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1474461 252622329 ZINC01386230 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88568 Fc1ccc(cc1)C(=O)OCn1ncc(Cl)c(Cl)c1=O InChI=1S/C12H7Cl2FN2O3/c13-9-5-16-17(11(18)10(9)14)6-20-12(19)7-1-3-8(15)4-2-7/h1-5H,6H2 YIGYFDAHCNYMIX-UHFFFAOYSA-N 41608 (4,5-dichloro-6-oxopyridazin-1-yl)methyl 4-fluorobenzoate::4-fluorobenzoic acid (4,5-dichloro-6-keto-pyridazin-1-yl)methyl ester::4-fluorobenzoic acid (4,5-dichloro-6-oxo-1-pyridazinyl)methyl ester::MLS000546963::SMR000180161::[4,5-bis(chloranyl)-6-oxidanylidene-pyridazin-1-yl]methyl 4-fluoranylbenzoate::[4,5-dichloro-6-oxo-1(6H)-pyridazinyl]methyl 4-fluorobenzenecarboxylate::cid_1474462 Tyrosine-protein kinase JAK2 Homo sapiens 1138 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41608&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1474462 252622330 ZINC01386231 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88569 CN(C)c1ccc(\C=C(/C)[N+]([O-])=O)cc1 InChI=1S/C11H14N2O2/c1-9(13(14)15)8-10-4-6-11(7-5-10)12(2)3/h4-8H,1-3H3/b9-8+ XLLDXYINDPHTJG-CMDGGOBGSA-N 47417 MLS000575611::N,N-dimethyl-4-(2-nitro-1-propen-1-yl)aniline::N,N-dimethyl-4-[(E)-2-nitroprop-1-enyl]aniline::SMR000185750::cid_2060089::dimethyl-[4-[(E)-2-nitroprop-1-enyl]phenyl]amine Tyrosine-protein kinase JAK2 Homo sapiens 3498 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47417&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2060089 252627729 ZINC12342778 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88570 Cc1[nH]c(=O)c(C(=O)\C=C\c2ccccc2F)c2CCCCc12 InChI=1S/C19H18FNO2/c1-12-14-7-3-4-8-15(14)18(19(23)21-12)17(22)11-10-13-6-2-5-9-16(13)20/h2,5-6,9-11H,3-4,7-8H2,1H3,(H,21,23)/b11-10+ YXZKKQAZJWYKNB-ZHACJKMWSA-N 47418 4-[(E)-3-(2-fluorophenyl)-1-oxoprop-2-enyl]-1-methyl-5,6,7,8-tetrahydro-2H-isoquinolin-3-one::4-[(E)-3-(2-fluorophenyl)acryloyl]-1-methyl-5,6,7,8-tetrahydro-2H-isoquinolin-3-one::4-[(E)-3-(2-fluorophenyl)prop-2-enoyl]-1-methyl-5,6,7,8-tetrahydro-2H-isoquinolin-3-one::4-[3-(2-fluorophenyl)acryloyl]-1-methyl-5,6,7,8-tetrahydro-3(2H)-isoquinolinone::MLS000575604::SMR000185742::cid_5721594 Tyrosine-protein kinase JAK2 Homo sapiens 5185 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47418&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5721594 252627730 ZINC08577599 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88571 COc1cccc(c1)N(C(C(=O)NCCc1ccccc1)c1cccs1)C(=O)CCl InChI=1S/C23H23ClN2O3S/c1-29-19-10-5-9-18(15-19)26(21(27)16-24)22(20-11-6-14-30-20)23(28)25-13-12-17-7-3-2-4-8-17/h2-11,14-15,22H,12-13,16H2,1H3,(H,25,28) ASSYJPCLSRNQGT-UHFFFAOYSA-N 47419 2-(N-(2-chloro-1-oxoethyl)-3-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide::2-(N-(2-chloroacetyl)-3-methoxy-anilino)-N-phenethyl-2-(2-thienyl)acetamide::2-(N-(2-chloroacetyl)-3-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide::2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide::2-[2-chloranylethanoyl-(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiophen-2-yl-ethanamide::MLS000583956::SMR000206942::cid_3689415 Tyrosine-protein kinase JAK2 Homo sapiens 1342 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47419&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 3689415 252627731 ZINC03034984 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88572 COC(=O)Oc1ccc(\C=C\C(=O)OC)cc1OC(=O)OC InChI=1S/C14H14O8/c1-18-12(15)7-5-9-4-6-10(21-13(16)19-2)11(8-9)22-14(17)20-3/h4-8H,1-3H3/b7-5+ QEWUDAKCWIEESB-FNORWQNLSA-N 47420 (E)-3-(3,4-Bis-methoxycarbonyloxy-phenyl)-acrylic acid methyl ester::(E)-3-(3,4-dicarbomethoxyoxyphenyl)acrylic acid methyl ester::(E)-3-[3,4-bis(methoxycarbonyloxy)phenyl]-2-propenoic acid methyl ester::MLS000589375::SMR000212779::cid_915140::methyl (E)-3-[3,4-bis(methoxycarbonyloxy)phenyl]prop-2-enoate Tyrosine-protein kinase JAK2 Homo sapiens 10710 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47420&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 915140 252627732 ZINC00500671 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88573 ClCC(=O)NC(=O)NC12CC3CC(CC(C3)C1)C2 InChI=1S/C13H19ClN2O2/c14-7-11(17)15-12(18)16-13-4-8-1-9(5-13)3-10(2-8)6-13/h8-10H,1-7H2,(H2,15,16,17,18) OBLFEICGDWLKQF-UHFFFAOYSA-N 47421 MLS000374912::N-(1-adamantylcarbamoyl)-2-chloranyl-ethanamide::N-(1-adamantylcarbamoyl)-2-chloro-acetamide::N-(1-adamantylcarbamoyl)-2-chloroacetamide::N-[(1-adamantylamino)-oxomethyl]-2-chloroacetamide::SMR000254266::cid_2378425 Tyrosine-protein kinase JAK2 Homo sapiens 4373 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47421&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2378425 252627733 ZINC03261731 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88574 Cc1ccc(C)c(Sc2ccc(NC(=O)CCl)cc2)c1 InChI=1S/C16H16ClNOS/c1-11-3-4-12(2)15(9-11)20-14-7-5-13(6-8-14)18-16(19)10-17/h3-9H,10H2,1-2H3,(H,18,19) KACFZWRSHRBOAC-UHFFFAOYSA-N 47422 2-chloranyl-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]ethanamide::2-chloro-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]acetamide::2-chloro-N-[4-[(2,5-dimethylphenyl)thio]phenyl]acetamide::MLS000334726::SMR000249484::cid_2566138 Tyrosine-protein kinase JAK2 Homo sapiens 7255 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47422&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2566138 252627734 ZINC03445996 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88575 O=C1OC(CC=C1)\C=C\c1ccccc1 InChI=1S/C13H12O2/c14-13-8-4-7-12(15-13)10-9-11-5-2-1-3-6-11/h1-6,8-10,12H,7H2/b10-9+ RLGHFVLWYYVMQZ-MDZDMXLPSA-N 47423 2-[(E)-2-phenylethenyl]-2,3-dihydropyran-6-one::2-[(E)-styryl]-2,3-dihydropyran-6-one::MLS000574880::SMR000156256::cid_5317826 Tyrosine-protein kinase JAK2 Homo sapiens 8516 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47423&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5317826 252627735 ZINC13130927 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88576 Oc1ccc(C=NN=C(C(=O)c2ccccc2)c2ccccc2)cc1O InChI=1S/C21H16N2O3/c24-18-12-11-15(13-19(18)25)14-22-23-20(16-7-3-1-4-8-16)21(26)17-9-5-2-6-10-17/h1-14,24-25H PTPHBFWUIVDPAV-UHFFFAOYSA-N 47424 4-[[[(Z)-2-hydroxy-1,2-diphenyl-vinyl]hydrazono]methyl]-o-benzoquinone::4-[[[(Z)-2-hydroxy-1,2-diphenylethenyl]hydrazinylidene]methyl]cyclohexa-3,5-diene-1,2-dione::4-[[[(Z)-2-oxidanyl-1,2-diphenyl-ethenyl]hydrazinylidene]methyl]cyclohexa-3,5-diene-1,2-dione::MLS000394999::SMR000248455::cid_15945139 Tyrosine-protein kinase JAK2 Homo sapiens 1666 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47424&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 15945139 252627736 ZINC15973750 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88577 CC1CCCC(NC(=O)NC(=O)CCl)C1C InChI=1S/C11H19ClN2O2/c1-7-4-3-5-9(8(7)2)13-11(16)14-10(15)6-12/h7-9H,3-6H2,1-2H3,(H2,13,14,15,16) HMBFDDSLYMRBIX-UHFFFAOYSA-N 47425 2-chloranyl-N-[(2,3-dimethylcyclohexyl)carbamoyl]ethanamide::2-chloro-N-[(2,3-dimethylcyclohexyl)carbamoyl]acetamide::2-chloro-N-[[(2,3-dimethylcyclohexyl)amino]-oxomethyl]acetamide::MLS000391455::SMR000260491::cid_5010280 Tyrosine-protein kinase JAK2 Homo sapiens 10610 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47425&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5010280 252627737 ZINC03887965 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88578 Oc1ccc(\C=C\C(=O)c2ccc(cc2)S(=O)(=O)N2CCCCCC2)cc1O InChI=1S/C21H23NO5S/c23-19(11-5-16-6-12-20(24)21(25)15-16)17-7-9-18(10-8-17)28(26,27)22-13-3-1-2-4-14-22/h5-12,15,24-25H,1-4,13-14H2/b11-5+ GXFSGKQBMVFDCW-VZUCSPMQSA-N 47426 (E)-1-[4-(1-azepanylsulfonyl)phenyl]-3-(3,4-dihydroxyphenyl)-2-propen-1-one::(E)-1-[4-(azepan-1-ylsulfonyl)phenyl]-3-(3,4-dihydroxyphenyl)prop-2-en-1-one::(E)-1-[4-(azepan-1-ylsulfonyl)phenyl]-3-[3,4-bis(oxidanyl)phenyl]prop-2-en-1-one::MLS000394827::SMR000242943::cid_5994055 Tyrosine-protein kinase JAK2 Homo sapiens 7505 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47426&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5994055 252627738 ZINC06225327 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88579 C1CC(CCN1)=C1c2ccsc2SCc2ccccc12 InChI=1S/C17H17NS2/c1-2-4-14-13(3-1)11-20-17-15(7-10-19-17)16(14)12-5-8-18-9-6-12/h1-4,7,10,18H,5-6,8-9,11H2 OUCFZPJFLDVIFR-UHFFFAOYSA-N 47427 4-thieno[2,3-c][2]benzothiepin-4(9H)-ylidenepiperidine::MLS000702402::SMR000224841::cid_15945717::formic acid;4-(5H-thieno[2,3-c][2]benzothiepin-10-ylidene)piperidine::methanoic acid;4-(5H-thieno[2,3-c][2]benzothiepin-10-ylidene)piperidine Tyrosine-protein kinase JAK2 Homo sapiens 10450 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47427&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 826462 252627739 ZINC00346418 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88580 COc1ccc(cc1)-c1cnc2c(CCC2(C#N)C#N)c1 InChI=1S/C17H13N3O/c1-21-15-4-2-12(3-5-15)14-8-13-6-7-17(10-18,11-19)16(13)20-9-14/h2-5,8-9H,6-7H2,1H3 JIWSNKGVMRFRBY-UHFFFAOYSA-N 47428 3-(4-methoxyphenyl)-1-pyrindan-7,7-dicarbonitrile::3-(4-methoxyphenyl)-5,6-dihydro-7H-cyclopenta[b]pyridine-7,7-dicarbonitrile::3-(4-methoxyphenyl)-5,6-dihydrocyclopenta[b]pyridine-7,7-dicarbonitrile::MLS000702566::SMR000224627::cid_824792 Tyrosine-protein kinase JAK2 Homo sapiens 2067 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47428&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 824792 252627740 ZINC00343671 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88581 Cc1nc2c(nc1Cl)n(C)c(=O)n(C)c2=O InChI=1S/C9H9ClN4O2/c1-4-6(10)12-7-5(11-4)8(15)14(3)9(16)13(7)2/h1-3H3 NFFGFYRLRNSHSV-UHFFFAOYSA-N 47429 7-chloranyl-1,3,6-trimethyl-pteridine-2,4-dione::7-chloro-1,3,6-trimethyl-2,4(1H,3H)-pteridinedione::7-chloro-1,3,6-trimethyl-pteridine-2,4-quinone::7-chloro-1,3,6-trimethylpteridine-2,4-dione::MLS000699625::SMR000224551::cid_822208 Tyrosine-protein kinase JAK2 Homo sapiens 4555 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47429&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 822208 252627741 ZINC00339457 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88582 Oc1ccc(\C=C2/SC(=S)N(Nc3ccccc3)C2=O)cc1O InChI=1S/C16H12N2O3S2/c19-12-7-6-10(8-13(12)20)9-14-15(21)18(16(22)23-14)17-11-4-2-1-3-5-11/h1-9,17,19-20H/b14-9- ATKORQIIELSXJL-ZROIWOOFSA-N 47430 (5Z)-3-anilino-5-(3,4-dihydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one::(5Z)-3-anilino-5-(3,4-dihydroxybenzylidene)-2-thioxo-thiazolidin-4-one::(5Z)-3-anilino-5-[(3,4-dihydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one::(5Z)-3-anilino-5-[(3,4-dihydroxyphenyl)methylidene]-2-sulfanylidene-4-thiazolidinone::(5Z)-5-[[3,4-bis(oxidanyl)phenyl]methylidene]-3-phenylazanyl-2-sulfanylidene-1,3-thiazolidin-4-one::MLS000685650::SMR000312614::cid_1630995 Tyrosine-protein kinase JAK2 Homo sapiens 10990 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47430&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1630995 252627742 ZINC01269285 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88583 CC1CCN(CCCNC(=O)c2cc3c(Cl)nc4ccccc4c3s2)CC1 InChI=1S/C21H24ClN3OS/c1-14-7-11-25(12-8-14)10-4-9-23-21(26)18-13-16-19(27-18)15-5-2-3-6-17(15)24-20(16)22/h2-3,5-6,13-14H,4,7-12H2,1H3,(H,23,26) MDTLCDMSANFHNI-UHFFFAOYSA-N 47431 4-chloranyl-N-[3-(4-methylpiperidin-1-yl)propyl]thieno[3,2-c]quinoline-2-carboxamide::4-chloro-N-[3-(4-methyl-1-piperidinyl)propyl]-2-thieno[3,2-c]quinolinecarboxamide::4-chloro-N-[3-(4-methylpiperidin-1-yl)propyl]thieno[3,2-c]quinoline-2-carboxamide::4-chloro-N-[3-(4-methylpiperidino)propyl]thieno[3,2-c]quinoline-2-carboxamide::MLS000871823::SMR000309542::cid_16187480 Tyrosine-protein kinase JAK2 Homo sapiens 4387 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47431&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 16187480 252627743 ZINC04938251 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88584 Oc1ccc(cc1O)C(=O)CSc1nnnn1-c1ccc(F)cc1 InChI=1S/C15H11FN4O3S/c16-10-2-4-11(5-3-10)20-15(17-18-19-20)24-8-14(23)9-1-6-12(21)13(22)7-9/h1-7,21-22H,8H2 NRRQKDJQQPTFNZ-UHFFFAOYSA-N 46022 1-(3,4-dihydroxyphenyl)-2-[1-(4-fluorophenyl)tetrazol-5-yl]sulfanylethanone::1-(3,4-dihydroxyphenyl)-2-[[1-(4-fluorophenyl)-5-tetrazolyl]thio]ethanone::1-(3,4-dihydroxyphenyl)-2-[[1-(4-fluorophenyl)tetrazol-5-yl]thio]ethanone::1-[3,4-bis(oxidanyl)phenyl]-2-[[1-(4-fluorophenyl)-1,2,3,4-tetrazol-5-yl]sulfanyl]ethanone::MLS-0238024.0001::cid_713665 Tyrosine-protein kinase JAK2 Homo sapiens 11060 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46022&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 713665 252626594 ZINC00107786 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88585 Cc1cc2[nH+]c3c(cn(C)c4ccccc34)c2cc1C InChI=1S/C18H16N2/c1-11-8-14-15-10-20(3)17-7-5-4-6-13(17)18(15)19-16(14)9-12(11)2/h4-10H,1-3H3/p+1 VWKXPFOCCSQQOA-UHFFFAOYSA-O 47432 5,8,9-trimethyl-11H-indolo[3,2-c]quinolin-5-ium;iodide::MLS000698834::SMR000230188::cid_10000306 Tyrosine-protein kinase JAK2 Homo sapiens 3850 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47432&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1236354 252627744 ZINC01019600 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88586 CC1CCCN(CCCNC(=O)c2cc3c(Cl)nc4ccccc4c3s2)C1 InChI=1S/C21H24ClN3OS/c1-14-6-4-10-25(13-14)11-5-9-23-21(26)18-12-16-19(27-18)15-7-2-3-8-17(15)24-20(16)22/h2-3,7-8,12,14H,4-6,9-11,13H2,1H3,(H,23,26) KBQSNNCVJNKFHP-UHFFFAOYSA-N 47433 4-chloranyl-N-[3-(3-methylpiperidin-1-yl)propyl]thieno[3,2-c]quinoline-2-carboxamide::4-chloro-N-[3-(3-methyl-1-piperidinyl)propyl]-2-thieno[3,2-c]quinolinecarboxamide::4-chloro-N-[3-(3-methylpiperidin-1-yl)propyl]thieno[3,2-c]quinoline-2-carboxamide::4-chloro-N-[3-(3-methylpiperidino)propyl]thieno[3,2-c]quinoline-2-carboxamide::MLS000871826::SMR000309545::cid_16008866 Tyrosine-protein kinase JAK2 Homo sapiens 3503 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47433&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 16008866 252627745 ZINC04938507 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88587 Oc1ccc(Cl)cc1\N=C\c1sc2ccccc2c1Cl InChI=1S/C15H9Cl2NOS/c16-9-5-6-12(19)11(7-9)18-8-14-15(17)10-3-1-2-4-13(10)20-14/h1-8,19H/b18-8+ AWZCZZCNLMDIIW-QGMBQPNBSA-N 47434 4-Chloro-2-{[1-(3-chloro-benzo[b]thiophen-2-yl)-meth-(E)-ylidene]-amino}-phenol::4-chloranyl-2-[(3-chloranyl-1-benzothiophen-2-yl)methylideneamino]phenol::4-chloro-2-[(3-chloro-1-benzothiophen-2-yl)methylideneamino]phenol::4-chloro-2-[(3-chlorobenzothiophen-2-yl)methyleneamino]phenol::MLS000587842::SMR000211891::cid_917309 Tyrosine-protein kinase JAK2 Homo sapiens 5938 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47434&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 917309 252627746 ZINC13110410 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88588 Cc1c(Cc2ccccc2)c(=O)oc2c(O)c(O)ccc12 InChI=1S/C17H14O4/c1-10-12-7-8-14(18)15(19)16(12)21-17(20)13(10)9-11-5-3-2-4-6-11/h2-8,18-19H,9H2,1H3 DLDOVDSFVAFCQE-UHFFFAOYSA-N 34851 3-benzyl-7,8-dihydroxy-4-methyl-2H-chromen-2-one::3-benzyl-7,8-dihydroxy-4-methyl-coumarin::3-benzyl-7,8-dihydroxy-4-methylchromen-2-one::4-methyl-7,8-bis(oxidanyl)-3-(phenylmethyl)chromen-2-one::7,8-dihydroxy-4-methyl-3-(phenylmethyl)-1-benzopyran-2-one::MLS000693314::SMR000300452::cid_5428528 Tyrosine-protein kinase JAK2 Homo sapiens 8616 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34851&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5428528 252617497 ZINC00615060 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88589 Cc1nc2ccccc2c(O)c1C(=O)C=Cc1ccccc1 InChI=1S/C19H15NO2/c1-13-18(17(21)12-11-14-7-3-2-4-8-14)19(22)15-9-5-6-10-16(15)20-13/h2-12H,1H3,(H,20,22) GLMXCYNQAMJMGO-UHFFFAOYSA-N 47435 2-methyl-3-[(E)-1-oxo-3-phenylprop-2-enyl]-1H-quinolin-4-one::2-methyl-3-[(E)-3-phenylacryloyl]-4-quinolone::2-methyl-3-[(E)-3-phenylprop-2-enoyl]-1H-quinolin-4-one::3-cinnamoyl-2-methyl-4(1H)-quinolinone::MLS000689897::SMR000298594::cid_5350830 Tyrosine-protein kinase JAK2 Homo sapiens 3125 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47435&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5350830 252627747 ZINC09046080 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88590 COc1ccc(cc1)-c1cc(n[nH]1)-c1cc(C)ccc1O InChI=1S/C17H16N2O2/c1-11-3-8-17(20)14(9-11)16-10-15(18-19-16)12-4-6-13(21-2)7-5-12/h3-10,20H,1-2H3,(H,18,19) FAXASVFSGHQOHP-UHFFFAOYSA-N 47436 (6E)-6-[5-(4-methoxyphenyl)-1,2-dihydropyrazol-3-ylidene]-4-methyl-1-cyclohexa-2,4-dienone::(6E)-6-[5-(4-methoxyphenyl)-1,2-dihydropyrazol-3-ylidene]-4-methyl-cyclohexa-2,4-dien-1-one::(6E)-6-[5-(4-methoxyphenyl)-1,2-dihydropyrazol-3-ylidene]-4-methylcyclohexa-2,4-dien-1-one::(6E)-6-[5-(4-methoxyphenyl)-3-pyrazolin-3-ylidene]-4-methyl-cyclohexa-2,4-dien-1-one::MLS000713614::SMR000273095::cid_5397853 Tyrosine-protein kinase JAK2 Homo sapiens 8759 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47436&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5397853 252627748 ZINC13126799 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88591 C(N1CCCCCC1)c1c[nH]c2ccccc12 InChI=1S/C15H20N2/c1-2-6-10-17(9-5-1)12-13-11-16-15-8-4-3-7-14(13)15/h3-4,7-8,11,16H,1-2,5-6,9-10,12H2 PDUPXVBNXBQTQH-UHFFFAOYSA-N 47437 3-(1-azepanylmethyl)-1H-indole;hydrochloride::3-(azepan-1-ylmethyl)-1H-indole;hydrochloride::MLS000688095::SMR000284264::cid_16192796 Tyrosine-protein kinase JAK2 Homo sapiens 10710 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47437&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search AWV 5Q1R,5QPG 763726 252627749 ZINC00237940 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88592 Cc1cccc(NC(=O)c2ccc(o2)[N+]([O-])=O)c1 InChI=1S/C12H10N2O4/c1-8-3-2-4-9(7-8)13-12(15)10-5-6-11(18-10)14(16)17/h2-7H,1H3,(H,13,15) SLTPHPQCJKBPDQ-UHFFFAOYSA-N 47438 MLS000712620::N-(3-methylphenyl)-5-nitro-2-furancarboxamide::N-(3-methylphenyl)-5-nitro-furan-2-carboxamide::N-(3-methylphenyl)-5-nitrofuran-2-carboxamide::N-(m-tolyl)-5-nitro-2-furamide::SMR000282387::cid_776890 Tyrosine-protein kinase JAK2 Homo sapiens 6884 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47438&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 776890 252627750 ZINC00267047 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88593 Cc1ccc2nc(C)cc(Nc3ccc(cc3)[N+]([O-])=O)c2c1 InChI=1S/C17H15N3O2/c1-11-3-8-16-15(9-11)17(10-12(2)18-16)19-13-4-6-14(7-5-13)20(21)22/h3-10H,1-2H3,(H,18,19) UJKFQZSNQANFHU-UHFFFAOYSA-N 47439 (2,6-dimethyl-4-quinolyl)-(4-nitrophenyl)amine::2,6-dimethyl-N-(4-nitrophenyl)-4-quinolinamine::2,6-dimethyl-N-(4-nitrophenyl)quinolin-4-amine::MLS000710716::SMR000280483::cid_2892697 Tyrosine-protein kinase JAK2 Homo sapiens 3311 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47439&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2892697 252627751 ZINC04894792 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88594 Cc1nc(c(Br)n1Cc1ccc(Cl)c(Cl)c1)[N+]([O-])=O InChI=1S/C11H8BrCl2N3O2/c1-6-15-11(17(18)19)10(12)16(6)5-7-2-3-8(13)9(14)4-7/h2-4H,5H2,1H3 GUNDYOSMXWMGCV-UHFFFAOYSA-N 47440 5-bromanyl-1-[(3,4-dichlorophenyl)methyl]-2-methyl-4-nitro-imidazole::5-bromo-1-(3,4-dichlorobenzyl)-2-methyl-4-nitro-1H-imidazole::5-bromo-1-(3,4-dichlorobenzyl)-2-methyl-4-nitro-imidazole::5-bromo-1-[(3,4-dichlorophenyl)methyl]-2-methyl-4-nitroimidazole::MLS000730654::SMR000308930::cid_16193626 Tyrosine-protein kinase JAK2 Homo sapiens 8441 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47440&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 16193626 252627752 ZINC04876040 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88595 COC(=O)COc1cccc2c1ccn(CC(=O)NCc1ccc(F)cc1)c2=O InChI=1S/C21H19FN2O5/c1-28-20(26)13-29-18-4-2-3-17-16(18)9-10-24(21(17)27)12-19(25)23-11-14-5-7-15(22)8-6-14/h2-10H,11-13H2,1H3,(H,23,25) JISCYQWWSXPVCV-UHFFFAOYSA-N 47441 2-[[2-[2-[(4-fluorobenzyl)amino]-2-keto-ethyl]-1-keto-5-isoquinolyl]oxy]acetic acid methyl ester::2-[[2-[2-[(4-fluorophenyl)methylamino]-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]acetic acid methyl ester::MLS000419410::SMR000320253::cid_2149568::methyl 2-[2-[2-[(4-fluorophenyl)methylamino]-2-oxidanylidene-ethyl]-1-oxidanylidene-isoquinolin-5-yl]oxyethanoate::methyl 2-[2-[2-[(4-fluorophenyl)methylamino]-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxyacetate Tyrosine-protein kinase JAK2 Homo sapiens 3341 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47441&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2149568 252627753 ZINC02712410 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88596 CNC(=O)c1nnsc1S(=O)c1ccc(Cl)cc1 InChI=1S/C10H8ClN3O2S2/c1-12-9(15)8-10(17-14-13-8)18(16)7-4-2-6(11)3-5-7/h2-5H,1H3,(H,12,15) QUIPMCDJRFFKGK-UHFFFAOYSA-N 47442 5-(4-chlorophenyl)sulfinyl-N-methyl-1,2,3-thiadiazole-4-carboxamide::5-(4-chlorophenyl)sulfinyl-N-methyl-4-thiadiazolecarboxamide::5-(4-chlorophenyl)sulfinyl-N-methyl-thiadiazole-4-carboxamide::5-(4-chlorophenyl)sulfinyl-N-methylthiadiazole-4-carboxamide::5-[(4-chlorophenyl)sulfinyl]-N-methyl-1,2,3-thiadiazole-4-carboxamide::MLS000707177::SMR000334557::cid_1486984 Tyrosine-protein kinase JAK2 Homo sapiens 2259 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47442&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1486984 252627754 ZINC04051850 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88597 FC(F)(F)c1cnc(NCCN2C(=O)C=CC2=O)c(Cl)c1 InChI=1S/C12H9ClF3N3O2/c13-8-5-7(12(14,15)16)6-18-11(8)17-3-4-19-9(20)1-2-10(19)21/h1-2,5-6H,3-4H2,(H,17,18) XRJVXAMPYWOKBH-UHFFFAOYSA-N 47443 1-(2-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]amino}ethyl)-1H-pyrrole-2,5-dione::1-[2-[[3-chloranyl-5-(trifluoromethyl)pyridin-2-yl]amino]ethyl]pyrrole-2,5-dione::1-[2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]ethyl]pyrrole-2,5-dione::1-[2-[[3-chloro-5-(trifluoromethyl)-2-pyridyl]amino]ethyl]-3-pyrroline-2,5-quinone::1-[2-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino]ethyl]pyrrole-2,5-dione::MLS000692082::SMR000333762::cid_1486292 Tyrosine-protein kinase JAK2 Homo sapiens 1760 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47443&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1486292 252627755 ZINC20405212 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88598 CCCCn1c2ccccc2n(CC(=O)c2ccc(Br)s2)c1=N InChI=1S/C17H18BrN3OS/c1-2-3-10-20-12-6-4-5-7-13(12)21(17(20)19)11-14(22)15-8-9-16(18)23-15/h4-9,19H,2-3,10-11H2,1H3 YIZLTIFLROUFJY-UHFFFAOYSA-N 47444 1-(5-bromo-2-thienyl)-2-(3-butyl-2-imino-benzimidazol-1-yl)ethanone;hydrobromide::1-(5-bromo-2-thiophenyl)-2-(3-butyl-2-imino-1-benzimidazolyl)ethanone;hydrobromide::1-(5-bromothiophen-2-yl)-2-(3-butyl-2-iminobenzimidazol-1-yl)ethanone;hydrobromide::2-(2-azanylidene-3-butyl-benzimidazol-1-yl)-1-(5-bromanylthiophen-2-yl)ethanone;hydrobromide::MLS000765776::SMR000278882::cid_2859351 Tyrosine-protein kinase JAK2 Homo sapiens 4365 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47444&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2859352 252627756 ZINC01771436 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88599 [O-][N+](=O)c1ccc(o1)C(=O)Nc1cccc(NC(=O)c2cccs2)c1 InChI=1S/C16H11N3O5S/c20-15(12-6-7-14(24-12)19(22)23)17-10-3-1-4-11(9-10)18-16(21)13-5-2-8-25-13/h1-9H,(H,17,20)(H,18,21) DVCOSFGUZDERBQ-UHFFFAOYSA-N 47445 5-nitro-N-[3-(2-thenoylamino)phenyl]-2-furamide::5-nitro-N-[3-(thiophen-2-ylcarbonylamino)phenyl]furan-2-carboxamide::5-nitro-N-[3-(thiophene-2-carbonylamino)phenyl]furan-2-carboxamide::5-nitro-N-[3-[[oxo(thiophen-2-yl)methyl]amino]phenyl]-2-furancarboxamide::MLS000765466::SMR000289571::cid_1164613 Tyrosine-protein kinase JAK2 Homo sapiens 3699 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47445&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1164613 252627757 ZINC00917720 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88600 ClCC(=O)NCc1cc(no1)-c1ccc(Cl)cc1 InChI=1S/C12H10Cl2N2O2/c13-6-12(17)15-7-10-5-11(16-18-10)8-1-3-9(14)4-2-8/h1-5H,6-7H2,(H,15,17) UQMGWSHJWYKFGS-UHFFFAOYSA-N 47446 2-chloranyl-N-[[3-(4-chlorophenyl)-1,2-oxazol-5-yl]methyl]ethanamide::2-chloro-N-[[3-(4-chlorophenyl)-1,2-oxazol-5-yl]methyl]acetamide::2-chloro-N-[[3-(4-chlorophenyl)-5-isoxazolyl]methyl]acetamide::2-chloro-N-[[3-(4-chlorophenyl)isoxazol-5-yl]methyl]acetamide::2-chloro-N-{[3-(4-chlorophenyl)-5-isoxazolyl]methyl}acetamide::MLS000764176::SMR000335010::cid_1477188 Tyrosine-protein kinase JAK2 Homo sapiens 8352 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47446&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1477188 252627758 ZINC01389584 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88601 Cc1ccc(Cn2ccsc2=NC(=O)CCl)cc1 InChI=1S/C13H13ClN2OS/c1-10-2-4-11(5-3-10)9-16-6-7-18-13(16)15-12(17)8-14/h2-7H,8-9H2,1H3 FNVXAXAJLFXSKP-UHFFFAOYSA-N 47447 2-chloranyl-N-[3-[(4-methylphenyl)methyl]-1,3-thiazol-2-ylidene]ethanamide::2-chloro-N-[3-(4-methylbenzyl)-4-thiazolin-2-ylidene]acetamide::2-chloro-N-[3-[(4-methylphenyl)methyl]-1,3-thiazol-2-ylidene]acetamide::2-chloro-N-[3-[(4-methylphenyl)methyl]-2-thiazolylidene]acetamide::MLS001033196::SMR000363636::cid_2412507 Tyrosine-protein kinase JAK2 Homo sapiens 7757 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47447&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2412507 252627759 ZINC18030864 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88602 ClCC(=O)N=c1sccn1Cc1ccc(Cl)cc1Cl InChI=1S/C12H9Cl3N2OS/c13-6-11(18)16-12-17(3-4-19-12)7-8-1-2-9(14)5-10(8)15/h1-5H,6-7H2 OYYOBWASUAPCJB-UHFFFAOYSA-N 47448 2-chloranyl-N-[3-[(2,4-dichlorophenyl)methyl]-1,3-thiazol-2-ylidene]ethanamide::2-chloro-N-[3-(2,4-dichlorobenzyl)-4-thiazolin-2-ylidene]acetamide::2-chloro-N-[3-[(2,4-dichlorophenyl)methyl]-1,3-thiazol-2-ylidene]acetamide::2-chloro-N-[3-[(2,4-dichlorophenyl)methyl]-2-thiazolylidene]acetamide::MLS001033186::SMR000363635::cid_2412504 Tyrosine-protein kinase JAK2 Homo sapiens 653 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47448&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2412504 252627760 ZINC12487933 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88603 ClCC(=O)N(C\C=C\c1ccccc1)c1ccc2OCCOc2c1 InChI=1S/C19H18ClNO3/c20-14-19(22)21(10-4-7-15-5-2-1-3-6-15)16-8-9-17-18(13-16)24-12-11-23-17/h1-9,13H,10-12,14H2/b7-4+ WCNGHJWXHCWDNG-QPJJXVBHSA-N 47449 2-chloranyl-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(E)-3-phenylprop-2-enyl]ethanamide::2-chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(E)-3-phenylprop-2-enyl]acetamide::2-chloro-N-[(E)-cinnamyl]-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide::MLS001010967::SMR000385219::cid_6235453 Tyrosine-protein kinase JAK2 Homo sapiens 2506 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47449&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 6235453 252627761 ZINC04204891 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88604 CC(C)(C)c1cc(NC(=O)CCl)n(n1)-c1ccccc1 InChI=1S/C15H18ClN3O/c1-15(2,3)12-9-13(17-14(20)10-16)19(18-12)11-7-5-4-6-8-11/h4-9H,10H2,1-3H3,(H,17,20) LJYKWBIMPOHGAE-UHFFFAOYSA-N 47450 MLS001033606::N-(5-tert-butyl-2-phenyl-3-pyrazolyl)-2-chloroacetamide::N-(5-tert-butyl-2-phenyl-pyrazol-3-yl)-2-chloranyl-ethanamide::N-(5-tert-butyl-2-phenyl-pyrazol-3-yl)-2-chloro-acetamide::N-(5-tert-butyl-2-phenylpyrazol-3-yl)-2-chloroacetamide::SMR000363937::cid_2369639 Tyrosine-protein kinase JAK2 Homo sapiens 3759 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47450&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2369639 252627762 ZINC03252718 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88605 CN(c1ccccc1)S(=O)(=O)c1cccc(c1)C(=O)NCCc1ccc(O)c(O)c1 InChI=1S/C22H22N2O5S/c1-24(18-7-3-2-4-8-18)30(28,29)19-9-5-6-17(15-19)22(27)23-13-12-16-10-11-20(25)21(26)14-16/h2-11,14-15,25-26H,12-13H2,1H3,(H,23,27) CRTNJAQTUJOJKC-UHFFFAOYSA-N 47451 MLS000773959::N-[2-(3,4-dihydroxyphenyl)ethyl]-3-[methyl(phenyl)sulfamoyl]benzamide::N-[2-[3,4-bis(oxidanyl)phenyl]ethyl]-3-[methyl(phenyl)sulfamoyl]benzamide::SMR000364776::cid_2358851 Tyrosine-protein kinase JAK2 Homo sapiens >40000 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47451&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2358851 252627763 ZINC03241392 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88606 ClCC(=O)N=c1sccn1Cc1cccc2ccccc12 InChI=1S/C16H13ClN2OS/c17-10-15(20)18-16-19(8-9-21-16)11-13-6-3-5-12-4-1-2-7-14(12)13/h1-9H,10-11H2 UWMDLXSQGLERIU-UHFFFAOYSA-N 47452 2-chloranyl-N-[3-(naphthalen-1-ylmethyl)-1,3-thiazol-2-ylidene]ethanamide::2-chloro-N-[3-(1-naphthalenylmethyl)-2-thiazolylidene]acetamide::2-chloro-N-[3-(1-naphthylmethyl)-4-thiazolin-2-ylidene]acetamide::2-chloro-N-[3-(naphthalen-1-ylmethyl)-1,3-thiazol-2-ylidene]acetamide::MLS000771958::SMR000376574::cid_4961625 Tyrosine-protein kinase JAK2 Homo sapiens 1036 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47452&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 4961625 252627764 ZINC13135527 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88607 Cc1ccc(NC(=O)C(=Cc2ccc(cc2)C(O)=O)C(=O)Nc2ccc(C)cc2C)c(C)c1 InChI=1S/C27H26N2O4/c1-16-5-11-23(18(3)13-16)28-25(30)22(15-20-7-9-21(10-8-20)27(32)33)26(31)29-24-12-6-17(2)14-19(24)4/h5-15H,1-4H3,(H,28,30)(H,29,31)(H,32,33) QZOHMGLHJDZRBE-UHFFFAOYSA-N 47453 4-[3-(2,4-dimethylanilino)-2-[(2,4-dimethylanilino)-oxomethyl]-3-oxoprop-1-enyl]benzoic acid::4-[3-(2,4-dimethylanilino)-2-[(2,4-dimethylphenyl)carbamoyl]-3-keto-prop-1-enyl]benzoic acid::4-[3-(2,4-dimethylanilino)-2-[(2,4-dimethylphenyl)carbamoyl]-3-oxoprop-1-enyl]benzoic acid::4-[3-[(2,4-dimethylphenyl)amino]-2-[(2,4-dimethylphenyl)carbamoyl]-3-oxidanylidene-prop-1-enyl]benzoic acid::MLS000761169::SMR000365295::cid_4882569 Tyrosine-protein kinase JAK2 Homo sapiens 5462 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47453&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 4882569 252627765 ZINC09491877 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88608 CCN1C\C(=C\c2ccc(OC)c(O)c2)C(=O)\C(C1)=C\c1ccc(OC)c(O)c1 InChI=1S/C23H25NO5/c1-4-24-13-17(9-15-5-7-21(28-2)19(25)11-15)23(27)18(14-24)10-16-6-8-22(29-3)20(26)12-16/h5-12,25-26H,4,13-14H2,1-3H3/b17-9-,18-10+ UDVWXXKUVFFLEB-BUOZRGFLSA-N 43474 (3Z,5E)-1-ethyl-3,5-bis(3-hydroxy-4-methoxy-benzylidene)-4-piperidone::(3Z,5E)-1-ethyl-3,5-bis[(3-hydroxy-4-methoxyphenyl)methylidene]-4-piperidinone::(3Z,5E)-1-ethyl-3,5-bis[(3-hydroxy-4-methoxyphenyl)methylidene]piperidin-4-one::(3Z,5E)-1-ethyl-3,5-bis[(4-methoxy-3-oxidanyl-phenyl)methylidene]piperidin-4-one::MLS000775870::SMR000371004::cid_2376815 Tyrosine-protein kinase JAK2 Homo sapiens 1500 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43474&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2376815 252624154 ZINC23230520 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88609 Cc1cccc(c1)N(Cc1ccccc1)C(=O)CCl InChI=1S/C16H16ClNO/c1-13-6-5-9-15(10-13)18(16(19)11-17)12-14-7-3-2-4-8-14/h2-10H,11-12H2,1H3 FKHCQUXRYRIDMR-UHFFFAOYSA-N 47454 2-chloranyl-N-(3-methylphenyl)-N-(phenylmethyl)ethanamide::2-chloro-N-(3-methylphenyl)-N-(phenylmethyl)acetamide::MLS000771412::N-benzyl-2-chloro-N-(3-methylphenyl)acetamide::N-benzyl-2-chloro-N-(m-tolyl)acetamide::SMR000376800::cid_2455004 Tyrosine-protein kinase JAK2 Homo sapiens 1631 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47454&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2455004 252627766 ZINC03338732 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88610 ClCC(=O)N=c1sccn1Cc1ccccc1Cl InChI=1S/C12H10Cl2N2OS/c13-7-11(17)15-12-16(5-6-18-12)8-9-3-1-2-4-10(9)14/h1-6H,7-8H2 PYEWRVJBQXWXNV-UHFFFAOYSA-N 47455 2-chloranyl-N-[3-[(2-chlorophenyl)methyl]-1,3-thiazol-2-ylidene]ethanamide::2-chloro-N-[3-(2-chlorobenzyl)-4-thiazolin-2-ylidene]acetamide::2-chloro-N-[3-[(2-chlorophenyl)methyl]-1,3-thiazol-2-ylidene]acetamide::2-chloro-N-[3-[(2-chlorophenyl)methyl]-2-thiazolylidene]acetamide::MLS001033149::SMR000363661::cid_2416356 Tyrosine-protein kinase JAK2 Homo sapiens 1110 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47455&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2416356 252627767 ZINC12487851 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88611 Oc1ccc(C=NN2CCN(CC2)C2c3ccccc3-c3ccccc23)cc1O InChI=1S/C24H23N3O2/c28-22-10-9-17(15-23(22)29)16-25-27-13-11-26(12-14-27)24-20-7-3-1-5-18(20)19-6-2-4-8-21(19)24/h1-10,15-16,24,28-29H,11-14H2 GKLQFLINJRNJOX-UHFFFAOYSA-N 47456 (4Z)-4-[[[4-(9H-fluoren-9-yl)-1-piperazinyl]amino]methylidene]-2-hydroxy-1-cyclohexa-2,5-dienone::(4Z)-4-[[[4-(9H-fluoren-9-yl)piperazin-1-yl]amino]methylidene]-2-hydroxycyclohexa-2,5-dien-1-one::(4Z)-4-[[[4-(9H-fluoren-9-yl)piperazin-1-yl]amino]methylidene]-2-oxidanyl-cyclohexa-2,5-dien-1-one::(4Z)-4-[[[4-(9H-fluoren-9-yl)piperazino]amino]methylene]-2-hydroxy-cyclohexa-2,5-dien-1-one::4-{[(E)-4-(9H-Fluoren-9-yl)-piperazin-1-ylimino]-methyl}-benzene-1,2-diol::MLS000777950::SMR000414344::cid_6914151 Tyrosine-protein kinase JAK2 Homo sapiens 5677 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47456&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 6914151 252627768 ZINC13118244 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88612 CCCC(=O)N(C1CC(C)C(C#N)(C#N)C1(C#N)C#N)N(C)C InChI=1S/C16H20N6O/c1-5-6-14(23)22(21(3)4)13-7-12(2)15(8-17,9-18)16(13,10-19)11-20/h12-13H,5-7H2,1-4H3 QCESUACIVCNKOD-UHFFFAOYSA-N 47457 Butyric acid N',N'-dimethyl-N-(2,2,3,3-tetracyano-4-methyl-cyclopentyl)-hydrazide::MLS001049390::N',N'-dimethyl-N-(2,2,3,3-tetracyano-4-methyl-cyclopentyl)butanehydrazide::N',N'-dimethyl-N-(2,2,3,3-tetracyano-4-methyl-cyclopentyl)butyrohydrazide::N',N'-dimethyl-N-(2,2,3,3-tetracyano-4-methylcyclopentyl)butanehydrazide::SMR000426787::cid_3270222 Tyrosine-protein kinase JAK2 Homo sapiens 4768 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47457&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 3270222 252627769 ZINC00500611 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88613 COc1ccccc1N(C(=O)CCl)c1cn(C(C)=O)c2ccccc12 InChI=1S/C19H17ClN2O3/c1-13(23)21-12-17(14-7-3-4-8-15(14)21)22(19(24)11-20)16-9-5-6-10-18(16)25-2/h3-10,12H,11H2,1-2H3 FKZSWIPTPGQJJO-UHFFFAOYSA-N 47458 2-chloranyl-N-(1-ethanoylindol-3-yl)-N-(2-methoxyphenyl)ethanamide::MLS001029455::N-(1-Acetyl-1H-indol-3-yl)-2-chloro-N-(2-methoxy-phenyl)-acetamide::N-(1-acetyl-3-indolyl)-2-chloro-N-(2-methoxyphenyl)acetamide::N-(1-acetylindol-3-yl)-2-chloro-N-(2-methoxyphenyl)acetamide::SMR000425526::cid_1208078 Tyrosine-protein kinase JAK2 Homo sapiens 4605 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47458&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1208078 252627770 ZINC00978319 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88614 CCCCCCN(C(=O)CCl)c1ccccc1 InChI=1S/C14H20ClNO/c1-2-3-4-8-11-16(14(17)12-15)13-9-6-5-7-10-13/h5-7,9-10H,2-4,8,11-12H2,1H3 SMNOCVUFCBKAEU-UHFFFAOYSA-N 47459 2-chloranyl-N-hexyl-N-phenyl-ethanamide::2-chloro-N-hexyl-N-phenyl-acetamide::2-chloro-N-hexyl-N-phenylacetamide::MLS001049285::SMR000427598::cid_1602469 Tyrosine-protein kinase JAK2 Homo sapiens 2113 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47459&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1602469 252627771 ZINC01823576 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88615 Oc1ccccc1OCCOc1ccccc1OCCOc1ccccc1O InChI=1S/C22H22O6/c23-17-7-1-3-9-19(17)25-13-15-27-21-11-5-6-12-22(21)28-16-14-26-20-10-4-2-8-18(20)24/h1-12,23-24H,13-16H2 CINIAUHMMYGXJU-UHFFFAOYSA-N 47460 2-[2-[2-[2-(2-hydroxyphenoxy)ethoxy]phenoxy]ethoxy]phenol::2-[2-[2-[2-(2-oxidanylphenoxy)ethoxy]phenoxy]ethoxy]phenol::MLS000777835::SMR000414220::cid_1900412 Tyrosine-protein kinase JAK2 Homo sapiens 7122 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47460&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1900412 252627772 ZINC02275132 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88616 Cn1c(Cl)cnc1\C=C\C(=O)c1ccccc1O InChI=1S/C13H11ClN2O2/c1-16-12(14)8-15-13(16)7-6-11(18)9-4-2-3-5-10(9)17/h2-8,17H,1H3/b7-6+ QBBFQBPTZNVWQY-VOTSOKGWSA-N 47461 (E)-3-(5-Chloro-1-methyl-1H-imidazol-2-yl)-1-(2-hydroxy-phenyl)-propenone::(E)-3-(5-chloranyl-1-methyl-imidazol-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one::(E)-3-(5-chloro-1-methyl-2-imidazolyl)-1-(2-hydroxyphenyl)-2-propen-1-one::(E)-3-(5-chloro-1-methyl-imidazol-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one::(E)-3-(5-chloro-1-methylimidazol-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one::MLS000777800::SMR000414242::cid_5898784 Tyrosine-protein kinase JAK2 Homo sapiens 6561 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47461&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5898784 252627773 ZINC04772728 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88617 Oc1ccc(NC2=CC(=O)c3ccccc3C2=O)cc1 InChI=1S/C16H11NO3/c18-11-7-5-10(6-8-11)17-14-9-15(19)12-3-1-2-4-13(12)16(14)20/h1-9,17-18H BLXXUTVXRNZUQX-UHFFFAOYSA-N 47462 2-(4-Hydroxy-phenylamino)-[1,4]naphthoquinone::2-(4-hydroxyanilino)-1,4-naphthoquinone::2-(4-hydroxyanilino)naphthalene-1,4-dione::2-[(4-hydroxyphenyl)amino]naphthalene-1,4-dione::MLS000778717::SMR000415498::cid_739245 Tyrosine-protein kinase JAK2 Homo sapiens 7532 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47462&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 739245 252627774 ZINC13655708 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88618 Clc1cc(cnc1Cl)S(=O)(=O)N1CCc2ccccc12 InChI=1S/C13H10Cl2N2O2S/c14-11-7-10(8-16-13(11)15)20(18,19)17-6-5-9-3-1-2-4-12(9)17/h1-4,7-8H,5-6H2 WDCHVRWSRQPXRU-UHFFFAOYSA-N 47463 1-(5,6-Dichloro-pyridine-3-sulfonyl)-2,3-dihydro-1H-indole::1-(5,6-dichloropyridin-3-yl)sulfonyl-2,3-dihydroindole::1-[(5,6-dichloro-3-pyridinyl)sulfonyl]-2,3-dihydroindole::1-[(5,6-dichloro-3-pyridyl)sulfonyl]indoline::1-[5,6-bis(chloranyl)pyridin-3-yl]sulfonyl-2,3-dihydroindole::MLS000778756::SMR000415533::cid_826907 Tyrosine-protein kinase JAK2 Homo sapiens 15840 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47463&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 826907 252627775 ZINC00347128 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88619 Cc1ccc(Nc2nc(N)nc(CCl)n2)cc1 InChI=1S/C11H12ClN5/c1-7-2-4-8(5-3-7)14-11-16-9(6-12)15-10(13)17-11/h2-5H,6H2,1H3,(H3,13,14,15,16,17) NDCXQFXHUZSBIB-UHFFFAOYSA-N 47464 6-(chloromethyl)-2-N-(4-methylphenyl)-1,3,5-triazine-2,4-diamine::6-(chloromethyl)-N2-(4-methylphenyl)-1,3,5-triazine-2,4-diamine::6-Chloromethyl-N-p-tolyl-[1,3,5]triazine-2,4-diamine::MLS000332923::SMR000436245::[4-amino-6-(chloromethyl)-s-triazin-2-yl]-(p-tolyl)amine::cid_935910 Tyrosine-protein kinase JAK2 Homo sapiens 1421 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47464&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 935910 252627776 ZINC18249993 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88620 COc1ccc(Nc2nc(N)nc(CCl)n2)cc1 InChI=1S/C11H12ClN5O/c1-18-8-4-2-7(3-5-8)14-11-16-9(6-12)15-10(13)17-11/h2-5H,6H2,1H3,(H3,13,14,15,16,17) WNMJRAUNFFYVKN-UHFFFAOYSA-N 47465 6-(chloromethyl)-2-N-(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine::6-(chloromethyl)-N2-(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine::6-Chloromethyl-N-(4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine::MLS000332743::SMR000436054::[4-amino-6-(chloromethyl)-s-triazin-2-yl]-(4-methoxyphenyl)amine::cid_931904 Tyrosine-protein kinase JAK2 Homo sapiens 2656 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47465&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 931904 252627777 ZINC18266199 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88621 Cc1nn2c(NCc3ccccn3)c3CCCc3nc2c1-c1ccccc1 InChI=1S/C22H21N5/c1-15-20(16-8-3-2-4-9-16)22-25-19-12-7-11-18(19)21(27(22)26-15)24-14-17-10-5-6-13-23-17/h2-6,8-10,13,24H,7,11-12,14H2,1H3 UFGNAHYYMKJYSC-UHFFFAOYSA-N 47466 (2-Methyl-3-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidin-8-yl)-pyridin-2-ylmethyl-amine::MLS000762840::SMR000439726::cid_1962660 Tyrosine-protein kinase JAK2 Homo sapiens 4277 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47466&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1962660 242053101 ZINC12421716 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88622 COc1ccc2nc(C)cc(Sc3nc4ccccc4s3)c2c1 InChI=1S/C18H14N2OS2/c1-11-9-17(13-10-12(21-2)7-8-14(13)19-11)23-18-20-15-5-3-4-6-16(15)22-18/h3-10H,1-2H3 PGWZWDHGBCTCBR-UHFFFAOYSA-N 47467 2-(6-methoxy-2-methyl-quinolin-4-yl)sulfanyl-1,3-benzothiazole::2-(6-methoxy-2-methylquinolin-4-yl)sulfanyl-1,3-benzothiazole::2-[(6-methoxy-2-methyl-4-quinolinyl)thio]-1,3-benzothiazole::2-[(6-methoxy-2-methyl-4-quinolyl)thio]-1,3-benzothiazole::MLS000737419::SMR000528135::cid_224687 Tyrosine-protein kinase JAK2 Homo sapiens 6962 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47467&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 224687 252627778 ZINC37868605 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88623 C(Cc1ccccc1)Nc1nc(nc2ccccc12)-c1ccccn1 InChI=1S/C21H18N4/c1-2-8-16(9-3-1)13-15-23-20-17-10-4-5-11-18(17)24-21(25-20)19-12-6-7-14-22-19/h1-12,14H,13,15H2,(H,23,24,25) FIBATSPGNRZQTN-UHFFFAOYSA-N 47468 MLS000769840::N-(2-phenylethyl)-2-(2-pyridinyl)-4-quinazolinamine::N-(2-phenylethyl)-2-pyridin-2-yl-quinazolin-4-amine::N-(2-phenylethyl)-2-pyridin-2-ylquinazolin-4-amine::Phenethyl-(2-pyridin-2-yl-quinazolin-4-yl)-amine::SMR000434573::cid_937982::phenethyl-[2-(2-pyridyl)quinazolin-4-yl]amine Tyrosine-protein kinase JAK2 Homo sapiens 3020 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47468&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 937982 252627779 ZINC00532702 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88624 O=C(C=C=Nc1ccccc1)C(=O)N=C=Cc1ccccc1 InChI=1S/C18H12N2O2/c21-17(12-14-19-16-9-5-2-6-10-16)18(22)20-13-11-15-7-3-1-4-8-15/h1-12H DDGJLZWYTNCSEI-UHFFFAOYSA-N 47469 2-keto-4-phenylimino-N-styrylidene-but-3-enamide::2-oxidanylidene-N-(2-phenylethenylidene)-4-phenylimino-but-3-enamide::2-oxo-N-(2-phenylethenylidene)-4-phenylimino-3-butenamide::2-oxo-N-(2-phenylethenylidene)-4-phenyliminobut-3-enamide::MLS000737077::SMR000394031::cid_238775 Tyrosine-protein kinase JAK2 Homo sapiens 10680 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47469&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 238775 252627780 ZINC01676023 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88625 OC(=O)c1[nH]c(=O)[nH]c(=O)c1F InChI=1S/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12) SEHFUALWMUWDKS-UHFFFAOYSA-N 47470 5-fluoranyl-2,4-bis(oxidanylidene)-1H-pyrimidine-6-carboxylic acid::5-fluoro-2,4-diketo-1H-pyrimidine-6-carboxylic acid::5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid::MLS000737636::SMR000393806::cid_69711 Tyrosine-protein kinase JAK2 Homo sapiens 6871 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47470&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search FOT 4C6M,3W1A,6HG2,7CA0,2E25,4C6L,2EG8 69711 252627781 ZINC01663959 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88626 CCOc1ccc(Nc2nc(N)nc(CCl)n2)cc1 InChI=1S/C12H14ClN5O/c1-2-19-9-5-3-8(4-6-9)15-12-17-10(7-13)16-11(14)18-12/h3-6H,2,7H2,1H3,(H3,14,15,16,17,18) GQUQMAJNMRIGRM-UHFFFAOYSA-N 47471 6-(chloromethyl)-2-N-(4-ethoxyphenyl)-1,3,5-triazine-2,4-diamine::6-(chloromethyl)-N2-(4-ethoxyphenyl)-1,3,5-triazine-2,4-diamine::6-Chloromethyl-N-(4-ethoxy-phenyl)-[1,3,5]triazine-2,4-diamine::MLS000332319::SMR000435017::[4-amino-6-(chloromethyl)-s-triazin-2-yl]-p-phenetyl-amine::cid_932657 Tyrosine-protein kinase JAK2 Homo sapiens 1924 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47471&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 932657 252627782 ZINC18249479 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88627 Nc1nc(CCl)nc(Nc2ccc3ccccc3c2)n1 InChI=1S/C14H12ClN5/c15-8-12-18-13(16)20-14(19-12)17-11-6-5-9-3-1-2-4-10(9)7-11/h1-7H,8H2,(H3,16,17,18,19,20) TUHLIPYSHRIRKP-UHFFFAOYSA-N 46587 6-(chloromethyl)-2-N-naphthalen-2-yl-1,3,5-triazine-2,4-diamine::6-(chloromethyl)-N2-(2-naphthalenyl)-1,3,5-triazine-2,4-diamine::6-(chloromethyl)-N2-naphthalen-2-yl-1,3,5-triazine-2,4-diamine::6-Chloromethyl-N-naphthalen-2-yl-[1,3,5]triazine-2,4-diamine::MLS000332349::SMR000435020::[4-amino-6-(chloromethyl)-s-triazin-2-yl]-(2-naphthyl)amine::cid_932617 Tyrosine-protein kinase JAK2 Homo sapiens 1081 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46587&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 932617 252627138 ZINC18180874 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88628 Nc1nc(CCl)nc(n1)N(c1ccccc1)c1ccccc1 InChI=1S/C16H14ClN5/c17-11-14-19-15(18)21-16(20-14)22(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10H,11H2,(H2,18,19,20,21) MYVHEXLYWFMBCL-UHFFFAOYSA-N 47472 6-(chloromethyl)-2-N,2-N-diphenyl-1,3,5-triazine-2,4-diamine::6-(chloromethyl)-N2,N2-diphenyl-1,3,5-triazine-2,4-diamine::6-Chloromethyl-N,N-diphenyl-[1,3,5]triazine-2,4-diamine::MLS000332280::SMR000435023::[4-amino-6-(chloromethyl)-s-triazin-2-yl]-diphenyl-amine::cid_934986 Tyrosine-protein kinase JAK2 Homo sapiens 1263 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47472&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 934986 252627783 ZINC00528456 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88629 Clc1ncc(cc1Br)S(=O)(=O)N1CCc2ccccc12 InChI=1S/C13H10BrClN2O2S/c14-11-7-10(8-16-13(11)15)20(18,19)17-6-5-9-3-1-2-4-12(9)17/h1-4,7-8H,5-6H2 IHCZZRFPMAHSIS-UHFFFAOYSA-N 46981 1-(5-Bromo-6-chloro-pyridine-3-sulfonyl)-2,3-dihydro-1H-indole::1-(5-bromanyl-6-chloranyl-pyridin-3-yl)sulfonyl-2,3-dihydroindole::1-(5-bromo-6-chloropyridin-3-yl)sulfonyl-2,3-dihydroindole::1-[(5-bromo-6-chloro-3-pyridinyl)sulfonyl]-2,3-dihydroindole::1-[(5-bromo-6-chloro-3-pyridyl)sulfonyl]indoline::MLS000778620::SMR000415414::cid_1034218 Tyrosine-protein kinase JAK2 Homo sapiens 5308 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46981&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 1034218 252627519 ZINC00703782 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88630 CC(C)(C)C(=O)Cc1nc2cc(Cl)ccc2oc1=O InChI=1S/C14H14ClNO3/c1-14(2,3)12(17)7-10-13(18)19-11-5-4-8(15)6-9(11)16-10/h4-6H,7H2,1-3H3 PAGOEFKSIGOYFT-UHFFFAOYSA-N 47473 (3Z)-6-chloranyl-3-(3,3-dimethyl-2-oxidanylidene-butylidene)-4H-1,4-benzoxazin-2-one::(3Z)-6-chloro-3-(2-keto-3,3-dimethyl-butylidene)-4H-1,4-benzoxazin-2-one::(3Z)-6-chloro-3-(3,3-dimethyl-2-oxobutylidene)-4H-1,4-benzoxazin-2-one::6-Chloro-3-[3,3-dimethyl-2-oxo-but-(E)-ylidene]-3,4-dihydro-benzo[1,4]oxazin-2-one::MLS000769641::SMR000434361::cid_5608316 Tyrosine-protein kinase JAK2 Homo sapiens 9549 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47473&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 51517452 252627784 ZINC13125521 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88631 Oc1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1cccs1 InChI=1S/C14H16N2O3S2/c17-13-5-3-12(4-6-13)15-7-9-16(10-8-15)21(18,19)14-2-1-11-20-14/h1-6,11,17H,7-10H2 AMAVAQLCDDYRMN-UHFFFAOYSA-N 47474 4-(4-thiophen-2-ylsulfonyl-1-piperazinyl)phenol::4-(4-thiophen-2-ylsulfonylpiperazin-1-yl)phenol::4-[4-(2-thienylsulfonyl)piperazino]phenol::MLS001002105::SMR000368302::cid_2471495 Tyrosine-protein kinase JAK2 Homo sapiens 5658 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47474&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2471495 252627785 ZINC03354308 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88632 CCN(CC)S(=O)(=O)c1cccc(c1)-n1c(O)c(C=Nc2ccccc2C(O)=O)c2ccccc2c1=O InChI=1S/C27H25N3O6S/c1-3-29(4-2)37(35,36)19-11-9-10-18(16-19)30-25(31)21-13-6-5-12-20(21)23(26(30)32)17-28-24-15-8-7-14-22(24)27(33)34/h5-17,32H,3-4H2,1-2H3,(H,33,34) BORXYUOPVPWHIP-UHFFFAOYSA-N 47475 2-[[(Z)-[2-[3-(diethylsulfamoyl)phenyl]-1,3-bis(oxidanylidene)isoquinolin-4-ylidene]methyl]amino]benzoic acid::2-[[(Z)-[2-[3-(diethylsulfamoyl)phenyl]-1,3-diketo-4-isoquinolylidene]methyl]amino]benzoic acid::2-[[(Z)-[2-[3-(diethylsulfamoyl)phenyl]-1,3-dioxo-4-isoquinolinylidene]methyl]amino]benzoic acid::2-[[(Z)-[2-[3-(diethylsulfamoyl)phenyl]-1,3-dioxoisoquinolin-4-ylidene]methyl]amino]benzoic acid::MLS001002340::SMR000368858::cid_6108189 Tyrosine-protein kinase JAK2 Homo sapiens >40000 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47475&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 6108189 252627786 ZINC13121694 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88633 Cc1cccc(Nc2nc(N)nc(CCl)n2)c1C InChI=1S/C12H14ClN5/c1-7-4-3-5-9(8(7)2)15-12-17-10(6-13)16-11(14)18-12/h3-5H,6H2,1-2H3,(H3,14,15,16,17,18) UXJDIALRLMIANN-UHFFFAOYSA-N 47476 6-(chloromethyl)-2-N-(2,3-dimethylphenyl)-1,3,5-triazine-2,4-diamine::6-(chloromethyl)-N2-(2,3-dimethylphenyl)-1,3,5-triazine-2,4-diamine::6-Chloromethyl-N-(2,3-dimethyl-phenyl)-[1,3,5]triazine-2,4-diamine::MLS000332329::SMR000435018::[4-amino-6-(chloromethyl)-s-triazin-2-yl]-(2,3-dimethylphenyl)amine::cid_936997 Tyrosine-protein kinase JAK2 Homo sapiens 2072 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47476&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 936997 252627787 ZINC18037536 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88634 Clc1ccc2oc(=O)c(CC(=O)c3ccco3)nc2c1 InChI=1S/C14H8ClNO4/c15-8-3-4-12-9(6-8)16-10(14(18)20-12)7-11(17)13-2-1-5-19-13/h1-6H,7H2 XZODWNWSRGNRJS-UHFFFAOYSA-N 47477 (3Z)-6-chloranyl-3-[2-(furan-2-yl)-2-oxidanylidene-ethylidene]-4H-1,4-benzoxazin-2-one::(3Z)-6-chloro-3-[2-(2-furanyl)-2-oxoethylidene]-4H-1,4-benzoxazin-2-one::(3Z)-6-chloro-3-[2-(2-furyl)-2-keto-ethylidene]-4H-1,4-benzoxazin-2-one::(3Z)-6-chloro-3-[2-(furan-2-yl)-2-oxoethylidene]-4H-1,4-benzoxazin-2-one::6-Chloro-3-[2-furan-2-yl-2-oxo-eth-(E)-ylidene]-3,4-dihydro-benzo[1,4]oxazin-2-one::MLS000769640::SMR000434360::cid_5614905 Tyrosine-protein kinase JAK2 Homo sapiens 8349 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47477&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 40559727 252627788 ZINC05731185 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88635 COc1ccc(c(n1)S(=O)(=O)c1ccc(Cl)cc1)[N+]([O-])=O InChI=1S/C12H9ClN2O5S/c1-20-11-7-6-10(15(16)17)12(14-11)21(18,19)9-4-2-8(13)3-5-9/h2-7H,1H3 PRKWNRUVAZZHPH-UHFFFAOYSA-N 47478 2-(4-chlorophenyl)sulfonyl-6-methoxy-3-nitro-pyridine::2-(4-chlorophenyl)sulfonyl-6-methoxy-3-nitropyridine::2-[(4-chlorophenyl)sulfonyl]-6-methoxy-3-nitropyridine::MLS000851064::SMR000457307::cid_2801235 Tyrosine-protein kinase JAK2 Homo sapiens 3261 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47478&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2801235 252627789 ZINC01046979 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88636 COc1cccc(F)c1C(C[N+]([O-])=O)c1c(N)n(C)c(=O)n(C)c1=O InChI=1S/C15H17FN4O5/c1-18-13(17)12(14(21)19(2)15(18)22)8(7-20(23)24)11-9(16)5-4-6-10(11)25-3/h4-6,8H,7,17H2,1-3H3 DQAXUFHBWMQUGP-UHFFFAOYSA-N 47479 6-amino-5-[1-(2-fluoro-6-methoxy-phenyl)-2-nitro-ethyl]-1,3-dimethyl-pyrimidine-2,4-quinone::6-amino-5-[1-(2-fluoro-6-methoxyphenyl)-2-nitroethyl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione::6-amino-5-[1-(2-fluoro-6-methoxyphenyl)-2-nitroethyl]-1,3-dimethylpyrimidine-2,4-dione::6-azanyl-5-[1-(2-fluoranyl-6-methoxy-phenyl)-2-nitro-ethyl]-1,3-dimethyl-pyrimidine-2,4-dione::MLS000861865::SMR000460649::cid_2732795 Tyrosine-protein kinase JAK2 Homo sapiens 4217 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47479&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2732795 252627790 ZINC01046176 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88637 COc1ccccc1C(C[N+]([O-])=O)c1c(N)n(C)c(=O)n(C)c1=O InChI=1S/C15H18N4O5/c1-17-13(16)12(14(20)18(2)15(17)21)10(8-19(22)23)9-6-4-5-7-11(9)24-3/h4-7,10H,8,16H2,1-3H3 RCJPUSOUOAULCR-UHFFFAOYSA-N 47480 6-amino-5-[1-(2-methoxyphenyl)-2-nitro-ethyl]-1,3-dimethyl-pyrimidine-2,4-quinone::6-amino-5-[1-(2-methoxyphenyl)-2-nitroethyl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione::6-amino-5-[1-(2-methoxyphenyl)-2-nitroethyl]-1,3-dimethylpyrimidine-2,4-dione::6-azanyl-5-[1-(2-methoxyphenyl)-2-nitro-ethyl]-1,3-dimethyl-pyrimidine-2,4-dione::MLS000861834::SMR000460618::cid_2732574 Tyrosine-protein kinase JAK2 Homo sapiens 6492 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47480&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 2732574 252627791 ZINC00101899 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 88638 COc1cc(\C=C2/COC\C(=C/c3ccc(O)c(OC)c3)C2=O)ccc1O InChI=1S/C21H20O6/c1-25-19-9-13(3-5-17(19)22)7-15-11-27-12-16(21(15)24)8-14-4-6-18(23)20(10-14)26-2/h3-10,22-23H,11-12H2,1-2H3/b15-7+,16-8+ FNGUUSNEVVYVES-BGPOSVGRSA-N 47481 (3E,5E)-3,5-bis[(3-methoxy-4-oxidanyl-phenyl)methylidene]oxan-4-one::(3E,5E)-3,5-bis[(4-hydroxy-3-methoxyphenyl)methylidene]-4-oxanone::(3E,5E)-3,5-bis[(4-hydroxy-3-methoxyphenyl)methylidene]oxan-4-one::(3E,5E)-3,5-divanillylidenetetrahydropyran-4-one::3,5-di(4-hydroxy-3-methoxybenzylidene)tetrahydro-2H-pyran-4-one::MLS000850945::SMR000456962::cid_5703486 Tyrosine-protein kinase JAK2 Homo sapiens 3615 PubChem 10.7270/Q20863Q9 aid1699 PubChem, PC 4/27/2009 5/29/2011 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47481&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 5703486 252627792 ZINC38145399 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 2B7A,3E62,3E63,3E64,3FUP,3IO7,3IOK,3JY9,3KCK,3KRR,3LPB,3Q32,3RVG,3TJC,3TJD,4AQC,4D0W,4D0X,4D1S,4HGE,4IVA,4JI9,4JIA,4P7E,4YTC,4YTF,4YTH,4YTI,4ZIM,5AEP,5CF4,5CF5,5CF6,5CF8,5USY,6DRW,6E2P,6E2Q,6VGL,6VN8,6VNB,6VNC,6VNE,6VNF,6VNG,6VNH,6VNI,6VNJ,6VNK,6VNL,6VNM,6VS3,6VSN,6WTN,6WTO,6WTP,6WTQ,7F7W,7LL4,7LL5,7REE,7UYW Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297