BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
125611	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(cnn5C)c4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C29H29N7O/c1-5-24(37)36-15-29(16-36)11-20(12-29)28-32-26(18-7-9-23-19(10-18)13-31-35(23)4)27(34(28)3)25-17(2)6-8-22-21(25)14-30-33-22/h5-10,13-14,20H,1,11-12,15-16H2,2-4H3,(H,30,33)	JMAJCZNZXAJZPJ-UHFFFAOYSA-N	72487	1-[6-[1-methyl-4-(1-methylindazol-5-yl)-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 1	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=72487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=72487&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973732	252649747							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125612	C=CC(=O)N1CC2(CC(c3nc(-c4ccccc4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C27H27N5O/c1-4-22(33)32-15-27(16-32)12-19(13-27)26-29-24(18-8-6-5-7-9-18)25(31(26)3)23-17(2)10-11-21-20(23)14-28-30-21/h4-11,14,19H,1,12-13,15-16H2,2-3H3,(H,28,30)	PMZAQPJTZUSWIT-UHFFFAOYSA-N	84340	1-[6-[1-methyl-5-(5-methyl-1H-indazol-4-yl)-4-phenyl-imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 2	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84340&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973633	252659435							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125613	C=CC(=O)N1CC2(CC(c3nc(-c4cccnc4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C26H26N6O/c1-4-21(33)32-14-26(15-32)10-18(11-26)25-29-23(17-6-5-9-27-12-17)24(31(25)3)22-16(2)7-8-20-19(22)13-28-30-20/h4-9,12-13,18H,1,10-11,14-15H2,2-3H3,(H,28,30)	BRGDRORGNMTGAI-UHFFFAOYSA-N	114599	1-[6-[1-methyl-5-(5-methyl-1H-indazol-4-yl)-4-(3-pyridyl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 3	GTPase KRas [G12C]	Homo sapiens		>10000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114599&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973674	252664092							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125614	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(OC)cc4F)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C28H28FN5O2/c1-5-23(35)34-14-28(15-34)11-17(12-28)27-31-25(19-8-7-18(36-4)10-21(19)29)26(33(27)3)24-16(2)6-9-22-20(24)13-30-32-22/h5-10,13,17H,1,11-12,14-15H2,2-4H3,(H,30,32)	TZYFIJMBRKKNMA-UHFFFAOYSA-N	114600	1-[6-[4-(2-fluoro-4-methoxy-phenyl)-1-methyl-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 4	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114600&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973660	252664093							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125615	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(N5CCOCC5)cc4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C31H34N6O2/c1-4-26(38)37-18-31(19-37)15-22(16-31)30-33-28(21-6-8-23(9-7-21)36-11-13-39-14-12-36)29(35(30)3)27-20(2)5-10-25-24(27)17-32-34-25/h4-10,17,22H,1,11-16,18-19H2,2-3H3,(H,32,34)	KOVQRKJEMPFTMD-UHFFFAOYSA-N	114601	1-[6-[1-methyl-5-(5-methyl-1H-indazol-4-yl)-4-(4-morpholinophenyl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 5	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114601&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973759	252664094							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125616	C=CC(=O)N1CC2(CC(c3nc(-c4cccc(N5CCOCC5)c4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C31H34N6O2/c1-4-26(38)37-18-31(19-37)15-22(16-31)30-33-28(21-6-5-7-23(14-21)36-10-12-39-13-11-36)29(35(30)3)27-20(2)8-9-25-24(27)17-32-34-25/h4-9,14,17,22H,1,10-13,15-16,18-19H2,2-3H3,(H,32,34)	XXLDMTZUBSIASS-UHFFFAOYSA-N	114603	1-[6-[1-methyl-5-(5-methyl-1H-indazol-4-yl)-4-(3-morpholinophenyl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 6	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114603&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973605	252664095							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125617	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5cnn(C)c5c4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C29H29N7O/c1-5-24(37)36-15-29(16-36)11-20(12-29)28-32-26(18-7-8-19-13-31-35(4)23(19)10-18)27(34(28)3)25-17(2)6-9-22-21(25)14-30-33-22/h5-10,13-14,20H,1,11-12,15-16H2,2-4H3,(H,30,33)	QCTQXESRTNVAPL-UHFFFAOYSA-N	114604	1-[6-[1-methyl-4-(1-methylindazol-6-yl)-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 7	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114604&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973691	252664096							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125618	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(-n5cnc(C6CC6)c5)cc4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C33H33N7O/c1-4-28(41)40-17-33(18-40)13-23(14-33)32-36-30(31(38(32)3)29-20(2)5-12-26-25(29)15-35-37-26)22-8-10-24(11-9-22)39-16-27(34-19-39)21-6-7-21/h4-5,8-12,15-16,19,21,23H,1,6-7,13-14,17-18H2,2-3H3,(H,35,37)	QYXLAVSOMZHQLZ-UHFFFAOYSA-N	114605	1-[6-[4-[4-(4-cyclopropylimidazol-1-yl)phenyl]-1-methyl-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 8	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114605&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			178422740	252664097							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125619	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(c4)nc(C)n5C)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C30H31N7O/c1-6-25(38)37-15-30(16-37)12-20(13-30)29-33-27(19-8-10-24-23(11-19)32-18(3)35(24)4)28(36(29)5)26-17(2)7-9-22-21(26)14-31-34-22/h6-11,14,20H,1,12-13,15-16H2,2-5H3,(H,31,34)	PHIVVJCRPNVDSC-UHFFFAOYSA-N	114606	1-[6-[4-(1,2-dimethylbenzimidazol-5-yl)-1-methyl-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 9	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114606&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			178422741	252664098							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125620	C=CC(=O)N1CC2(CC(c3nc(-c4cnn(CCN5CCOCC5)c4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C30H36N8O2/c1-4-25(39)37-18-30(19-37)13-21(14-30)29-33-27(22-15-32-38(17-22)8-7-36-9-11-40-12-10-36)28(35(29)3)26-20(2)5-6-24-23(26)16-31-34-24/h4-6,15-17,21H,1,7-14,18-19H2,2-3H3,(H,31,34)	YDKNGTQWTYGUAE-UHFFFAOYSA-N	114607	1-[6-[1-methyl-5-(5-methyl-1H-indazol-4-yl)-4-[1-(2-morpholinoethyl)pyrazol-4-yl]imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 10	GTPase KRas [G12C]	Homo sapiens		>10000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114607&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			178422742	252664099							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125621	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(cnn5C)c4C)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C30H31N7O/c1-6-25(38)37-15-30(16-37)11-19(12-30)29-33-27(20-8-10-24-21(18(20)3)14-32-36(24)5)28(35(29)4)26-17(2)7-9-23-22(26)13-31-34-23/h6-10,13-14,19H,1,11-12,15-16H2,2-5H3,(H,31,34)	CHSWFAQUSCTWQJ-UHFFFAOYSA-N	114608	1-[6-[4-(1,4-dimethylindazol-5-yl)-1-methyl-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 11	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114608&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973575	252664100							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125622	C=CC(=O)N1CC2(CC(c3nc(-c4cn(C)nc4C)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C26H29N7O/c1-6-21(34)33-13-26(14-33)9-17(10-26)25-28-23(19-12-31(4)30-16(19)3)24(32(25)5)22-15(2)7-8-20-18(22)11-27-29-20/h6-8,11-12,17H,1,9-10,13-14H2,2-5H3,(H,27,29)	VCUDZSFARVGEBP-UHFFFAOYSA-N	114609	1-[6-[4-(1,3-dimethylpyrazol-4-yl)-1-methyl-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 12	GTPase KRas [G12C]	Homo sapiens		>10000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114609&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973648	252664101							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125623	C=CC(=O)N1CC2(CC(c3nc(-c4cnn(CC)c4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C26H29N7O/c1-5-21(34)32-14-26(15-32)9-17(10-26)25-29-23(18-11-28-33(6-2)13-18)24(31(25)4)22-16(3)7-8-20-19(22)12-27-30-20/h5,7-8,11-13,17H,1,6,9-10,14-15H2,2-4H3,(H,27,30)	KLHGJLMAMQNEHZ-UHFFFAOYSA-N	114610	1-[6-[4-(1-ethylpyrazol-4-yl)-1-methyl-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 13	GTPase KRas [G12C]	Homo sapiens		>10000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114610&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973756	252664102							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125624	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5nn(C)cc5c4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C29H29N7O/c1-5-24(37)36-15-29(16-36)11-20(12-29)28-31-26(18-7-9-22-19(10-18)14-34(3)33-22)27(35(28)4)25-17(2)6-8-23-21(25)13-30-32-23/h5-10,13-14,20H,1,11-12,15-16H2,2-4H3,(H,30,32)	IQIQTABVPNSDNC-UHFFFAOYSA-N	114611	1-[6-[1-methyl-4-(2-methylindazol-5-yl)-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 14	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114611&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973753	252664103							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125625	C=CC(=O)N1CC2(CC(c3nc(-c4cnn(CCOC)c4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C27H31N7O2/c1-5-22(35)33-15-27(16-33)10-18(11-27)26-30-24(19-12-29-34(14-19)8-9-36-4)25(32(26)3)23-17(2)6-7-21-20(23)13-28-31-21/h5-7,12-14,18H,1,8-11,15-16H2,2-4H3,(H,28,31)	ABDSXFXXKGAHKP-UHFFFAOYSA-N	114612	1-[6-[4-[1-(2-methoxyethyl)pyrazol-4-yl]-1-methyl-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 15	GTPase KRas [G12C]	Homo sapiens		>10000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114612&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973595	252664104							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125626	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(c4)c(C)nn5C)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C30H31N7O/c1-6-25(38)37-15-30(16-37)12-20(13-30)29-32-27(19-8-10-24-21(11-19)18(3)34-36(24)5)28(35(29)4)26-17(2)7-9-23-22(26)14-31-33-23/h6-11,14,20H,1,12-13,15-16H2,2-5H3,(H,31,33)	ATZWIYHOSKGXDT-UHFFFAOYSA-N	114613	1-[6-[4-(1,3-dimethylindazol-5-yl)-1-methyl-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 16	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114613&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973601	252664105							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125627	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5ocnc5c4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C28H26N6O2/c1-4-23(35)34-13-28(14-34)10-18(11-28)27-31-25(17-6-8-22-21(9-17)29-15-36-22)26(33(27)3)24-16(2)5-7-20-19(24)12-30-32-20/h4-9,12,15,18H,1,10-11,13-14H2,2-3H3,(H,30,32)	FXKHATUTYNYAGX-UHFFFAOYSA-N	114614	1-[6-[4-(1,3-benzoxazol-5-yl)-1-methyl-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 17	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114614&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973625	252664106							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125628	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(c4)OCCN5C)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C30H32N6O2/c1-5-25(37)36-16-30(17-36)13-20(14-30)29-32-27(19-7-9-23-24(12-19)38-11-10-34(23)3)28(35(29)4)26-18(2)6-8-22-21(26)15-31-33-22/h5-9,12,15,20H,1,10-11,13-14,16-17H2,2-4H3,(H,31,33)	LQYJVWCZANUGKM-UHFFFAOYSA-N	114615	1-[6-[1-methyl-4-(4-methyl-2,3-dihydro-1,4-benzoxazin-7-yl)-5-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 18	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114615&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973622	252664107							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125629	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(OCC(=O)N(C)C)cc4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C31H34N6O3/c1-6-25(38)37-17-31(18-37)13-21(14-31)30-33-28(20-8-10-22(11-9-20)40-16-26(39)35(3)4)29(36(30)5)27-19(2)7-12-24-23(27)15-32-34-24/h6-12,15,21H,1,13-14,16-18H2,2-5H3,(H,32,34)	QGWBVCYWGZEUCS-UHFFFAOYSA-N	114616	N,N-dimethyl-2-[4-[1-methyl-5-(5-methyl-1H-indazol-4-yl)-2-(2-prop-2-enoyl-2-azaspiro[3.3]heptan-6-yl)imidazol-4-yl]phenoxy]acetamide::US20260060961, Example 19	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114616&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973670	252664108							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125630	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(OCC(=O)N5CCOCC5)cc4)c(-c4c(C)ccc5[nH]ncc45)n3C)C2)C1	InChI=1S/C33H36N6O4/c1-4-27(40)39-19-33(20-39)15-23(16-33)32-35-30(31(37(32)3)29-21(2)5-10-26-25(29)17-34-36-26)22-6-8-24(9-7-22)43-18-28(41)38-11-13-42-14-12-38/h4-10,17,23H,1,11-16,18-20H2,2-3H3,(H,34,36)	VOYXBHFCZQMWAT-UHFFFAOYSA-N	114617	1-[6-[1-methyl-5-(5-methyl-1H-indazol-4-yl)-4-[4-(2-morpholino-2-oxo-ethoxy)phenyl]imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 20	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114617&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973651	252664109							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125631	C=CC(=O)N1CC2(CC(c3nc(-c4ncc(OC)s4)c(-c4cc5cn[nH]c5cc4C)n3C)C2)C1	InChI=1S/C25H26N6O2S/c1-5-19(32)31-12-25(13-31)8-16(9-25)23-28-21(24-26-11-20(33-4)34-24)22(30(23)3)17-7-15-10-27-29-18(15)6-14(17)2/h5-7,10-11,16H,1,8-9,12-13H2,2-4H3,(H,27,29)	KFCSHVSPRVOYNI-UHFFFAOYSA-N	114618	1-[6-[1-methyl-5-(1-methylindazol-5-yl)-4-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 21	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114618&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			178422743	252664110							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125632	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(C(=O)NCCN(C)C)cc4)c(-c4c(C)ccc5[nH]cnc45)n3C)C2)C1	InChI=1S/C32H37N7O2/c1-6-25(40)39-17-32(18-39)15-23(16-32)30-36-27(21-8-10-22(11-9-21)31(41)33-13-14-37(3)4)29(38(30)5)26-20(2)7-12-24-28(26)35-19-34-24/h6-12,19,23H,1,13-18H2,2-5H3,(H,33,41)(H,34,35)	IGUSIPOCILZARB-UHFFFAOYSA-N	114619	1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-(1-methylindazol-5-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 22	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114619&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			178422744	252664111							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125633	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(C(=O)NCC(F)(F)F)c(OC)c4)c(-c4c(C)ccc5[nH]cnc45)n3C)C2)C1	InChI=1S/C31H31F3N6O3/c1-5-23(41)40-14-30(15-40)11-19(12-30)28-38-25(27(39(28)3)24-17(2)6-9-21-26(24)37-16-36-21)18-7-8-20(22(10-18)43-4)29(42)35-13-31(32,33)34/h5-10,16,19H,1,11-15H2,2-4H3,(H,35,42)(H,36,37)	TZWKYFXHPWRBBT-UHFFFAOYSA-N	114620	1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-(4-morpholinophenyl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 23	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114620&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			178422745	252664112							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125634	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5nn(C)cc5c4)c(-c4c(C)ccc5[nH]cnc45)n3CC)C2)C1	InChI=1S/C30H31N7O/c1-5-24(38)36-15-30(16-36)12-21(13-30)29-33-26(19-8-10-22-20(11-19)14-35(4)34-22)28(37(29)6-2)25-18(3)7-9-23-27(25)32-17-31-23/h5,7-11,14,17,21H,1,6,12-13,15-16H2,2-4H3,(H,31,32)	CSDDHAYMADXRTD-UHFFFAOYSA-N	114621	1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-(2-methylindazol-5-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 24	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114621&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			178422746	252664113							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125635	CCC(=O)N1CC2(CC(c3nc(-c4c(C)ccc5[nH]ncc45)c(-c4ccc5c(cnn5C)c4)n3C)C2)C1	InChI=1S/C29H31N7O/c1-5-24(37)36-15-29(16-36)11-20(12-29)28-32-26(25-17(2)6-8-22-21(25)14-30-33-22)27(34(28)3)18-7-9-23-19(10-18)13-31-35(23)4/h6-10,13-14,20H,5,11-12,15-16H2,1-4H3,(H,30,33)	HAZLGJIYGDXPAY-UHFFFAOYSA-N	114622	1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-[4-(2-morpholino-2-oxo-ethoxy)phenyl]imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::1-[6-[1-methyl-5-(1-methylindazol-5-yl)-4-(5-methyl-1H-indazol-4-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 25	GTPase KRas [G12C]	Homo sapiens		>10000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114622&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			178422747	252664114							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125636	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(cnn5C)c4)c(-c4cc(O)cc5ccccc45)n3C)C2)C1	InChI=1S/C31H29N5O2/c1-4-27(38)36-17-31(18-36)14-22(15-31)30-33-28(20-9-10-26-21(11-20)16-32-35(26)3)29(34(30)2)25-13-23(37)12-19-7-5-6-8-24(19)25/h4-13,16,22,37H,1,14-15,17-18H2,2-3H3	JAEIGOQGAIMAIO-UHFFFAOYSA-N	114623	1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-(1-methylindazol-5-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 26	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114623&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973628	252664115							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125637	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(N5CCOCC5)cc4)c(-c4cc(O)cc5ccccc45)n3C)C2)C1	InChI=1S/C33H34N4O3/c1-3-29(39)37-20-33(21-37)18-24(19-33)32-34-30(22-8-10-25(11-9-22)36-12-14-40-15-13-36)31(35(32)2)28-17-26(38)16-23-6-4-5-7-27(23)28/h3-11,16-17,24,38H,1,12-15,18-21H2,2H3	MODMPCODXWKQPT-UHFFFAOYSA-N	114624	1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-(4-morpholinophenyl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 27	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114624&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973596	252664116							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125638	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5nn(C)cc5c4)c(-c4cc(O)cc5ccccc45)n3C)C2)C1	InChI=1S/C31H29N5O2/c1-4-27(38)36-17-31(18-36)14-22(15-31)30-32-28(20-9-10-26-21(11-20)16-34(2)33-26)29(35(30)3)25-13-23(37)12-19-7-5-6-8-24(19)25/h4-13,16,22,37H,1,14-15,17-18H2,2-3H3	IFTCZPOPUMRCPB-UHFFFAOYSA-N	114625	1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-(2-methylindazol-5-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 28	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114625&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973730	252664117							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125639	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(OCC(=O)N5CCOCC5)cc4)c(-c4cc(O)cc5ccccc45)n3C)C2)C1	InChI=1S/C35H36N4O5/c1-3-30(41)39-21-35(22-39)18-25(19-35)34-36-32(33(37(34)2)29-17-26(40)16-24-6-4-5-7-28(24)29)23-8-10-27(11-9-23)44-20-31(42)38-12-14-43-15-13-38/h3-11,16-17,25,40H,1,12-15,18-22H2,2H3	GACUAMLGARHWEC-UHFFFAOYSA-N	114626	1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-[4-(2-morpholino-2-oxo-ethoxy)phenyl]imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 29	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114626&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973593	252664118							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125640	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(CN5CCOCC5)cc4)c(-c4cc(O)cc5ccccc45)n3C)C2)C1	InChI=1S/C34H36N4O3/c1-3-30(40)38-21-34(22-38)18-26(19-34)33-35-31(24-10-8-23(9-11-24)20-37-12-14-41-15-13-37)32(36(33)2)29-17-27(39)16-25-6-4-5-7-28(25)29/h3-11,16-17,26,39H,1,12-15,18-22H2,2H3	CFOFMPYATWEEFG-UHFFFAOYSA-N	114627	1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-[4-(morpholinomethyl)phenyl]imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 30	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114627&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973694	252664119							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125641	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(CN5CCN(C)CC5)cc4)c(-c4cc(O)cc5ccccc45)n3C)C2)C1	InChI=1S/C35H39N5O2/c1-4-31(42)40-22-35(23-40)19-27(20-35)34-36-32(25-11-9-24(10-12-25)21-39-15-13-37(2)14-16-39)33(38(34)3)30-18-28(41)17-26-7-5-6-8-29(26)30/h4-12,17-18,27,41H,1,13-16,19-23H2,2-3H3	RZPLMBSHEBSNLT-UHFFFAOYSA-N	114628	1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 31	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114628&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973624	252664120							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125642	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(cnn5C)c4)c(-c4cc(O)cc5ccccc45)n3CC)C2)C1	InChI=1S/C32H31N5O2/c1-4-28(39)36-18-32(19-36)15-23(16-32)31-34-29(21-10-11-27-22(12-21)17-33-35(27)3)30(37(31)5-2)26-14-24(38)13-20-8-6-7-9-25(20)26/h4,6-14,17,23,38H,1,5,15-16,18-19H2,2-3H3	VECXWIDCRZUPLD-UHFFFAOYSA-N	114629	1-[6-[1-ethyl-5-(3-hydroxy-1-naphthyl)-4-(1-methylindazol-5-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 32	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114629&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973695	252664121							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125643	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(N5CCOCC5)cc4)c(-c4cc(O)cc5ccccc45)n3CC)C2)C1	InChI=1S/C34H36N4O3/c1-3-30(40)37-21-34(22-37)19-25(20-34)33-35-31(23-9-11-26(12-10-23)36-13-15-41-16-14-36)32(38(33)4-2)29-18-27(39)17-24-7-5-6-8-28(24)29/h3,5-12,17-18,25,39H,1,4,13-16,19-22H2,2H3	MIQMMIWUXXDTOI-UHFFFAOYSA-N	114630	1-[6-[1-ethyl-5-(3-hydroxy-1-naphthyl)-4-(4-morpholinophenyl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 33	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114630&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973710	252664122							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125644	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(cnn5C)c4)c(-c4cccc5ccccc45)n3C)C2)C1	InChI=1S/C31H29N5O/c1-4-27(37)36-18-31(19-36)15-23(16-31)30-33-28(21-12-13-26-22(14-21)17-32-35(26)3)29(34(30)2)25-11-7-9-20-8-5-6-10-24(20)25/h4-14,17,23H,1,15-16,18-19H2,2-3H3	XNNHYMUSCIXJDY-UHFFFAOYSA-N	114631	1-[6-[1-methyl-4-(1-methylindazol-5-yl)-5-(1-naphthyl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 34	GTPase KRas [G12C]	Homo sapiens		>10000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114631&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973699	252664123							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125645	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(cnn5C)c4)c(-c4cc(O)cc5cccc(Cl)c45)n3C)C2)C1	InChI=1S/C31H28ClN5O2/c1-4-26(39)37-16-31(17-37)13-21(14-31)30-34-28(19-8-9-25-20(10-19)15-33-36(25)3)29(35(30)2)23-12-22(38)11-18-6-5-7-24(32)27(18)23/h4-12,15,21,38H,1,13-14,16-17H2,2-3H3	VZIDARTVONCQPY-UHFFFAOYSA-N	114632	1-[6-[5-(8-chloro-3-hydroxy-1-naphthyl)-1-methyl-4-(1-methylindazol-5-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 35	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114632&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973645	252664124							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125646	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(cnn5C)c4)c(-c4cccc5sc(N)c(C#N)c45)n3C)C2)C1	InChI=1S/C30H27N7OS/c1-4-24(38)37-15-30(16-37)11-19(12-30)29-34-26(17-8-9-22-18(10-17)14-33-36(22)3)27(35(29)2)20-6-5-7-23-25(20)21(13-31)28(32)39-23/h4-10,14,19H,1,11-12,15-16,32H2,2-3H3	RHEUPXOTPSCSHY-UHFFFAOYSA-N	794432	2-amino-4-[3-methyl-5-(1-methylindazol-5-yl)-2-(2-prop-2-enoyl-2-azaspiro[3.3]heptan-6-yl)imidazol-4-yl]benzothiophene-3-carbonitrile::US20260060961, Example 36	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794432&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973618	528825895							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125647	C=CC(=O)N1CC2(CC(c3nc(-c4ccc(C(=O)NCCN5CCOCC5)cc4)c(-c4cc(O)cc5ccccc45)n3C)C2)C1	InChI=1S/C36H39N5O4/c1-3-31(43)41-22-36(23-41)20-27(21-36)34-38-32(33(39(34)2)30-19-28(42)18-26-6-4-5-7-29(26)30)24-8-10-25(11-9-24)35(44)37-12-13-40-14-16-45-17-15-40/h3-11,18-19,27,42H,1,12-17,20-23H2,2H3,(H,37,44)	XQWMZPMRFHLXRD-UHFFFAOYSA-N	794433	4-[5-(3-hydroxy-1-naphthyl)-1-methyl-2-(2-prop-2-enoyl-2-azaspiro[3.3]heptan-6-yl)imidazol-4-yl]-N-(2-morpholinoethyl)benzamide::US20260060961, Example 37	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794433&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973614	528825896							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125648	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(cnn5C)c4)c(-c4c(C)c(C)cc5[nH]ncc45)n3C)C2)C1	InChI=1S/C30H31N7O/c1-6-25(38)37-15-30(16-37)11-21(12-30)29-33-27(19-7-8-24-20(10-19)13-32-36(24)5)28(35(29)4)26-18(3)17(2)9-23-22(26)14-31-34-23/h6-10,13-14,21H,1,11-12,15-16H2,2-5H3,(H,31,34)	UNUZHHRVWMOXHJ-UHFFFAOYSA-N	794434	1-[6-[5-(5,6-dimethyl-1H-indazol-4-yl)-1-methyl-4-(1-methylindazol-5-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 38	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794434&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973573	528825897							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125649	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(cnn5C)c4)c(-c4cc(O)ccc4C(F)(F)F)n3C)C2)C1	InChI=1S/C28H26F3N5O2/c1-4-23(38)36-14-27(15-36)11-18(12-27)26-33-24(16-5-8-22-17(9-16)13-32-35(22)3)25(34(26)2)20-10-19(37)6-7-21(20)28(29,30)31/h4-10,13,18,37H,1,11-12,14-15H2,2-3H3	JUKDCKVNWVTJLP-UHFFFAOYSA-N	794435	1-[6-[5-[5-hydroxy-2-(trifluoromethyl)phenyl]-1-methyl-4-(1-methylindazol-5-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 39	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794435&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973724	528825898							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125650	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(cnn5C)c4)c(-c4cc(C#N)cc5[nH]ncc45)n3C)C2)C1	InChI=1S/C29H26N8O/c1-4-25(38)37-15-29(16-37)10-20(11-29)28-33-26(18-5-6-24-19(9-18)13-32-36(24)3)27(35(28)2)21-7-17(12-30)8-23-22(21)14-31-34-23/h4-9,13-14,20H,1,10-11,15-16H2,2-3H3,(H,31,34)	REGBRYFJQVIKGT-UHFFFAOYSA-N	794436	4-[3-methyl-5-(1-methylindazol-5-yl)-2-(2-prop-2-enoyl-2-azaspiro[3.3]heptan-6-yl)imidazol-4-yl]-1H-indazole-6-carbonitrile::US20260060961, Example 40	GTPase KRas [G12C]	Homo sapiens		 5500							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794436&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973727	528825899							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125651	C=CC(=O)N1CC2(CC(c3nc(-c4ccc5c(cnn5C)c4)c(-c4cc(Cl)cc5[nH]ncc45)n3C)C2)C1	InChI=1S/C28H26ClN7O/c1-4-24(37)36-14-28(15-36)10-18(11-28)27-32-25(16-5-6-23-17(7-16)12-31-35(23)3)26(34(27)2)20-8-19(29)9-22-21(20)13-30-33-22/h4-9,12-13,18H,1,10-11,14-15H2,2-3H3,(H,30,33)	HHSAMJLAWZZKBP-UHFFFAOYSA-N	794437	1-[6-[5-(6-chloro-1H-indazol-4-yl)-1-methyl-4-(1-methylindazol-5-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 41	GTPase KRas [G12C]	Homo sapiens		<1000							US Patent		10.7270/Q2W95G5Q			US20260060961	JONES, CD; BELFIELD, A; BORDONI, C	5/19/2010	7/12/2011	Jazz Pharmaceuticals Ireland	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794437&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search			170973667	528825900							1	MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9YMP,9YMO,9YMN,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10