BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 191040 Cn1nccc1Nc1nccc(-c2nc3c(s2)C(C)(C)N(Cc2cccc(Cl)c2)C3=O)n1 InChI=1S/C22H20ClN7OS/c1-22(2)18-17(20(31)30(22)12-13-5-4-6-14(23)11-13)28-19(32-18)15-7-9-24-21(26-15)27-16-8-10-25-29(16)3/h4-11H,12H2,1-3H3,(H,24,26,27) SUOQJUBTIVWDPN-UHFFFAOYSA-N 276465 US12522616, Compound WX001 Mitogen-activated protein kinase 1 Homo sapiens 0.240 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276465 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276465&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130309699 378158131 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191041 Cn1nccc1Nc1nccc(-c2nc3c(s2)C(C)(C)N(Cc2cccc(F)c2)C3=O)n1 InChI=1S/C22H20FN7OS/c1-22(2)18-17(20(31)30(22)12-13-5-4-6-14(23)11-13)28-19(32-18)15-7-9-24-21(26-15)27-16-8-10-25-29(16)3/h4-11H,12H2,1-3H3,(H,24,26,27) XYXIMMAZVNUNHA-UHFFFAOYSA-N 276468 US12522616, Compound WX002 Mitogen-activated protein kinase 1 Homo sapiens 0.350 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276468 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276468&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130309701 378158134 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191042 Cn1nccc1Nc1nccc(-c2nc3c(s2)C(C)(C)N(Cc2ccc(F)c(F)c2)C3=O)n1 InChI=1S/C22H19F2N7OS/c1-22(2)18-17(20(32)31(22)11-12-4-5-13(23)14(24)10-12)29-19(33-18)15-6-8-25-21(27-15)28-16-7-9-26-30(16)3/h4-10H,11H2,1-3H3,(H,25,27,28) VPSAJSZFRXQRKW-UHFFFAOYSA-N 276503 US12522616, Compound WX003 Mitogen-activated protein kinase 1 Homo sapiens 0.370 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276503 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276503&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130309730 378158169 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191043 CC1(C)c2sc(-c3ccnc(NC4CCOCC4)n3)nc2C(=O)N1Cc1cccc(F)c1 InChI=1S/C23H24FN5O2S/c1-23(2)19-18(21(30)29(23)13-14-4-3-5-15(24)12-14)28-20(32-19)17-6-9-25-22(27-17)26-16-7-10-31-11-8-16/h3-6,9,12,16H,7-8,10-11,13H2,1-2H3,(H,25,26,27) KLXOITBCMUPRPS-UHFFFAOYSA-N 276512 US12522616, Compound WX004 Mitogen-activated protein kinase 1 Homo sapiens 0.250 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276512 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276512&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130309736 378158178 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191044 Cc1cnc(Nc2ccnn2C)nc1-c1nc2c(s1)C(C)(C)N(Cc1cccc(Cl)c1)C2=O InChI=1S/C23H22ClN7OS/c1-13-11-25-22(27-16-8-9-26-30(16)4)29-17(13)20-28-18-19(33-20)23(2,3)31(21(18)32)12-14-6-5-7-15(24)10-14/h5-11H,12H2,1-4H3,(H,25,27,29) PONUSVFCPXPCCD-UHFFFAOYSA-N 276536 US12522616, Compound WX005 Mitogen-activated protein kinase 1 Homo sapiens 0.050 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276536 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276536&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130309432 378158202 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191045 Cc1cnc(Nc2ccnn2C)nc1-c1nc2c(s1)C(C)(C)N(Cc1cccc(F)c1)C2=O InChI=1S/C23H22FN7OS/c1-13-11-25-22(27-16-8-9-26-30(16)4)29-17(13)20-28-18-19(33-20)23(2,3)31(21(18)32)12-14-6-5-7-15(24)10-14/h5-11H,12H2,1-4H3,(H,25,27,29) FJGLPZZZNWMMII-UHFFFAOYSA-N 276632 US12522616, Compound WX006 Mitogen-activated protein kinase 1 Homo sapiens 0.300 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276632 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276632&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130309841 378158298 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191046 CC1(C)c2sc(-c3ccnc(NC4CCOCC4)n3)nc2C(=O)N1Cc1cccc(Cl)c1 InChI=1S/C23H24ClN5O2S/c1-23(2)19-18(21(30)29(23)13-14-4-3-5-15(24)12-14)28-20(32-19)17-6-9-25-22(27-17)26-16-7-10-31-11-8-16/h3-6,9,12,16H,7-8,10-11,13H2,1-2H3,(H,25,26,27) LIYPTCFKJFHSFD-UHFFFAOYSA-N 276648 US12522616, Compound WX007 Mitogen-activated protein kinase 1 Homo sapiens 0.390 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276648 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276648&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130302190 378158314 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191047 Cc1cnc(Nc2ccnn2C(F)F)nc1-c1nc2c(s1)C(C)(C)N(Cc1cccc(F)c1)C2=O InChI=1S/C23H20F3N7OS/c1-12-10-27-22(29-15-7-8-28-33(15)21(25)26)31-16(12)19-30-17-18(35-19)23(2,3)32(20(17)34)11-13-5-4-6-14(24)9-13/h4-10,21H,11H2,1-3H3,(H,27,29,31) SSXZVTSPJVRGHX-UHFFFAOYSA-N 276649 US12522616, Compound WX008 Mitogen-activated protein kinase 1 Homo sapiens 0.520 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276649 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276649&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130302470 378158315 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191048 [2H]C([2H])([2H])n1nccc1Nc1ncc(C)c(-c2nc3c(s2)C(C)(C)N(Cc2cccc(F)c2)C3=O)n1 InChI=1S/C23H22FN7OS/c1-13-11-25-22(27-16-8-9-26-30(16)4)29-17(13)20-28-18-19(33-20)23(2,3)31(21(18)32)12-14-6-5-7-15(24)10-14/h5-11H,12H2,1-4H3,(H,25,27,29)/i4D3 FJGLPZZZNWMMII-GKOSEXJESA-N 276650 US12522616, Compound WX009 Mitogen-activated protein kinase 1 Homo sapiens 0.640 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276650 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276650&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130309856 378158316 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191049 Cc1cc(Nc2ncc(C)c(-c3nc4c(s3)C(C)(C)N(Cc3cccc(F)c3)C4=O)n2)n(C)n1 InChI=1S/C24H24FN7OS/c1-13-11-26-23(27-17-9-14(2)30-31(17)5)29-18(13)21-28-19-20(34-21)24(3,4)32(22(19)33)12-15-7-6-8-16(25)10-15/h6-11H,12H2,1-5H3,(H,26,27,29) XBDKAMNYFFSECG-UHFFFAOYSA-N 276651 US12522616, Compound WX0010 Mitogen-activated protein kinase 1 Homo sapiens 0.140 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276651 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276651&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130309857 378158317 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191050 COCCn1nccc1Nc1ncc(C)c(-c2nc3c(s2)C(C)(C)N(Cc2cccc(F)c2)C3=O)n1 InChI=1S/C25H26FN7O2S/c1-15-13-27-24(29-18-8-9-28-33(18)10-11-35-4)31-19(15)22-30-20-21(36-22)25(2,3)32(23(20)34)14-16-6-5-7-17(26)12-16/h5-9,12-13H,10-11,14H2,1-4H3,(H,27,29,31) MIJDFBOLMSIFTK-UHFFFAOYSA-N 276652 US12522616, Compound WX0011 Mitogen-activated protein kinase 1 Homo sapiens 0.980 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276652 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276652&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130309858 378158318 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191051 Cc1cnc(Nc2ccnn2C2CC2)nc1-c1nc2c(s1)C(C)(C)N(Cc1cccc(F)c1)C2=O InChI=1S/C25H24FN7OS/c1-14-12-27-24(29-18-9-10-28-33(18)17-7-8-17)31-19(14)22-30-20-21(35-22)25(2,3)32(23(20)34)13-15-5-4-6-16(26)11-15/h4-6,9-12,17H,7-8,13H2,1-3H3,(H,27,29,31) AEDYDYZCTJPHGM-UHFFFAOYSA-N 276653 US12522616, Compound WX0012 Mitogen-activated protein kinase 1 Homo sapiens 0.480 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276653 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276653&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130309860 378158319 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64 191052 COc1cc(Nc2ncc(C)c(-c3nc4c(s3)C(C)(C)N(Cc3cccc(F)c3)C4=O)n2)n(C)n1 InChI=1S/C24H24FN7O2S/c1-13-11-26-23(27-16-10-17(34-5)30-31(16)4)29-18(13)21-28-19-20(35-21)24(2,3)32(22(19)33)12-14-7-6-8-15(25)9-14/h6-11H,12H2,1-5H3,(H,26,27,29) BKQDLXUCUPESJG-UHFFFAOYSA-N 276654 US12522616, Compound WX0013 Mitogen-activated protein kinase 1 Homo sapiens 0.190 US Patent 10.7270/Q2RR242B US12522616 Li, Y; Liu, N; Yu, T; Wu, C; Li, J; Chen, S 1/13/2026 5/26/2026 D3 Bio (Wuxi) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276654 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2239&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276654&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 130309859 378158320 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 8PVU,6G54,4QTE,4QTA,4NIF,4FMQ,2Y9Q,8R5F,8PT5,8PT3,8PT1,8PT0,8PSY,8PSW,8PST,8PSR,7OPM,9LNR,5LCK,4ZXT,4N0S,4G6O,4G6N,4FV9,4FV8,4FV7,4FV6,4FV5,4FV4,4FV3,4FV2,4FV1,4FV0,4FUY,4FUX,3SA0,3I60,3I5Z,2OJJ,2OJI,2OJG,4QPA,4QP9,4QP8,4QP7,4QP6,4QP4,4QP3,4QP2,4QP1,8AOJ,8AOI,8AOH,8AOG,8AOF,8AOE,8AOD,8AOC,8AOB,8AOA,8AO9,8AO8,8AO7,8AO6,8AO5,8AO4,8AO3,8AO2,7XC1,7X4U,7W5O,7NR9,7NR8,7NR5,7NR3,7NQW,7NQQ,7AUV,6RQ4,6QAW,6QAQ,6QAL,6QAH,6QAG,6QA4,6QA3,6QA1,6Q7T,6Q7S,6Q7K,6GJD,6GJB,6GE0,6GDQ,6GDM,6G9N,6G9M,6G9K,6G9J,6G9H,6G9D,6G9A,6G97,6G93,6G92,6G91,6G8X,5LCJ,5AX3,3W55,1WZY,1TVO,5BVF,5BVE,5BVD,5BUJ,5BUI,5BUE,5WP1,8U8K,8U8J,6OPI,6OPH,6OPG,8RQX,8RMB,5V61,5V60,4N4S,4IZA,4IZ7,4I5H,5K4I,8ZJV,5V62,4XJ0,6DMG Mitogen-activated protein kinase 1 MK01_HUMAN P28482 A8CZ64