BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 210364 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccc(-c3ccnn3C)c2)nc1F InChI=1S/C26H29FN4O3/c1-15(2)18-10-11-21(29-24(18)27)23(30-25(32)19-8-5-9-20(19)26(33)34)17-7-4-6-16(14-17)22-12-13-28-31(22)3/h4,6-7,10-15,19-20,23H,5,8-9H2,1-3H3,(H,30,32)(H,33,34) UCPNPIZXHDQZRT-UHFFFAOYSA-N 369880 US20260021085, Compound 1 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1442 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369880&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 130321341 402366669 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210365 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccc(-c3cnco3)c2)nc1F InChI=1S/C25H26FN3O4/c1-14(2)17-9-10-20(28-23(17)26)22(29-24(30)18-7-4-8-19(18)25(31)32)16-6-3-5-15(11-16)21-12-27-13-33-21/h3,5-6,9-14,18-19,22H,4,7-8H2,1-2H3,(H,29,30)(H,31,32) AIUZPZLMCHYNSU-UHFFFAOYSA-N 369907 US20260021085, Compound 2 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 426 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369907 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369907&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 130321472 402366696 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210366 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccc(-c3ccno3)c2)nc1F InChI=1S/C25H26FN3O4/c1-14(2)17-9-10-20(28-23(17)26)22(29-24(30)18-7-4-8-19(18)25(31)32)16-6-3-5-15(13-16)21-11-12-27-33-21/h3,5-6,9-14,18-19,22H,4,7-8H2,1-2H3,(H,29,30)(H,31,32) TWUWXBGYSUCISO-UHFFFAOYSA-N 369908 US20260021085, Compound 3 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 630 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369908&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 130321356 402366697 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210367 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccc(-c3ccn[nH]3)c2)nc1F InChI=1S/C25H27FN4O3/c1-14(2)17-9-10-21(28-23(17)26)22(29-24(31)18-7-4-8-19(18)25(32)33)16-6-3-5-15(13-16)20-11-12-27-30-20/h3,5-6,9-14,18-19,22H,4,7-8H2,1-2H3,(H,27,30)(H,29,31)(H,32,33) AJYKFOBLKSMBHZ-UHFFFAOYSA-N 369917 US20260021085, Compound 4 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 178 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369917 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369917&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 171096840 402366706 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210368 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccc3cn[nH]c3c2)nc1F InChI=1S/C23H25FN4O3/c1-12(2)15-8-9-18(26-21(15)24)20(13-6-7-14-11-25-28-19(14)10-13)27-22(29)16-4-3-5-17(16)23(30)31/h6-12,16-17,20H,3-5H2,1-2H3,(H,25,28)(H,27,29)(H,30,31) PGBYWTDWPLYULJ-UHFFFAOYSA-N 370148 US20260021085, Compound 5 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 84.0 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370148&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 174303895 402357232 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210369 O=C(O)[C@H]1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C22H23FN2O3/c23-20-15(13-9-10-13)11-12-18(24-20)19(14-5-2-1-3-6-14)25-21(26)16-7-4-8-17(16)22(27)28/h1-3,5-6,11-13,16-17,19H,4,7-10H2,(H,25,26)(H,27,28) OBPTUQYVEIJBNK-UHFFFAOYSA-N 370178 US20260021085, Compound 6 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 272 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370178 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370178&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 130321165 402357262 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210370 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccc3c2[nH]c(=O)n3C)cc1F InChI=1S/C25H28FN3O4/c1-13(2)15-11-10-14(12-19(15)26)21(27-23(30)16-6-4-7-17(16)24(31)32)18-8-5-9-20-22(18)28-25(33)29(20)3/h5,8-13,16-17,21H,4,6-7H2,1-3H3,(H,27,30)(H,28,33)(H,31,32) UQGBFFRGAROTJP-UHFFFAOYSA-N 370378 Synthesis of (1S,2R)-2-(((R)-(3-fluoro-4-isopropylphenyl)(1-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)methyl) carbamoyl)cyclopentane-1-carboxylic acid ::US20260021085, Compound 7 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 884 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370378 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370378&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 171096921 402357363 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210371 CC(C)c1c(F)cc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccccc2)cc1F InChI=1S/C23H25F2NO3/c1-13(2)20-18(24)11-15(12-19(20)25)21(14-7-4-3-5-8-14)26-22(27)16-9-6-10-17(16)23(28)29/h3-5,7-8,11-13,16-17,21H,6,9-10H2,1-2H3,(H,26,27)(H,28,29) UUWBMPQOKMJUIE-UHFFFAOYSA-N 372260 US20260021085, Compound 8 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 239 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372260 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372260&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254659 402359201 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210372 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccc3[nH]c(=O)oc23)cc1 InChI=1S/C24H26N2O5/c1-13(2)14-9-11-15(12-10-14)20(18-7-4-8-19-21(18)31-24(30)25-19)26-22(27)16-5-3-6-17(16)23(28)29/h4,7-13,16-17,20H,3,5-6H2,1-2H3,(H,25,30)(H,26,27)(H,28,29) AMXZBWZRBJLYBA-UHFFFAOYSA-N 372261 US20260021085, Compound 9 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 879 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372261 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372261&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 171096838 402359202 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210373 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccc3oc(=O)[nH]c23)cc1 InChI=1S/C24H26N2O5/c1-13(2)14-9-11-15(12-10-14)20(18-7-4-8-19-21(18)26-24(30)31-19)25-22(27)16-5-3-6-17(16)23(28)29/h4,7-13,16-17,20H,3,5-6H2,1-2H3,(H,25,27)(H,26,30)(H,28,29) OGUYGODUDJROIG-UHFFFAOYSA-N 372262 US20260021085, Compound 10 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 2934 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372262 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372262&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 171096899 402359203 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210374 CC(C)c1ccc([C@@H](NC(=O)C2CC(NC(=O)OC(C)(C)C)CC2C(=O)O)c2ccccc2)cc1 InChI=1S/C28H36N2O5/c1-17(2)18-11-13-20(14-12-18)24(19-9-7-6-8-10-19)30-25(31)22-15-21(16-23(22)26(32)33)29-27(34)35-28(3,4)5/h6-14,17,21-24H,15-16H2,1-5H3,(H,29,34)(H,30,31)(H,32,33) UWTDBQIXEHMZAM-UHFFFAOYSA-N 372263 US20260021085, Compound 11 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1945 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372263 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372263&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254498 402359204 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210375 O=C(O)[C@H]1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)cn1 InChI=1S/C22H24N2O3/c25-21(17-7-4-8-18(17)22(26)27)24-20(15-5-2-1-3-6-15)19-12-11-16(13-23-19)14-9-10-14/h1-3,5-6,11-14,17-18,20H,4,7-10H2,(H,24,25)(H,26,27) BLELBPHBACILHJ-UHFFFAOYSA-N 372264 US20260021085, Compound 12 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1731 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372264 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372264&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254815 402359205 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210376 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccccc2NC(=O)C2CNC2)cc1 InChI=1S/C27H33N3O4/c1-16(2)17-10-12-18(13-11-17)24(30-26(32)20-7-5-8-21(20)27(33)34)22-6-3-4-9-23(22)29-25(31)19-14-28-15-19/h3-4,6,9-13,16,19-21,24,28H,5,7-8,14-15H2,1-2H3,(H,29,31)(H,30,32)(H,33,34) SQECATSWXXFSKE-UHFFFAOYSA-N 372265 US20260021085, Compound 13 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 2362 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372265 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372265&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254931 402359206 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210377 CC1(c2ccc([C@@H](NC(=O)[C@@H]3CCC[C@@H]3C(=O)O)c3ccccc3)cc2)CC1 InChI=1S/C24H27NO3/c1-24(14-15-24)18-12-10-17(11-13-18)21(16-6-3-2-4-7-16)25-22(26)19-8-5-9-20(19)23(27)28/h2-4,6-7,10-13,19-21H,5,8-9,14-15H2,1H3,(H,25,26)(H,27,28) GFFNPEKWLUFDDC-UHFFFAOYSA-N 372266 US20260021085, Compound 14 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1005 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372266 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372266&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132255048 402359207 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210378 O=C(O)[C@H]1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CCC2)cn1 InChI=1S/C23H26N2O3/c26-22(18-10-5-11-19(18)23(27)28)25-21(16-6-2-1-3-7-16)20-13-12-17(14-24-20)15-8-4-9-15/h1-3,6-7,12-15,18-19,21H,4-5,8-11H2,(H,25,26)(H,27,28) DPTBRBMOFOJDPQ-UHFFFAOYSA-N 372267 US20260021085, Compound 15 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 497 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372267 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372267&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254706 402359208 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210379 CC(C)c1ccc([C@@H](NC(=O)C2CC(O)CC2C(=O)O)c2ccccc2)cc1 InChI=1S/C23H27NO4/c1-14(2)15-8-10-17(11-9-15)21(16-6-4-3-5-7-16)24-22(26)19-12-18(25)13-20(19)23(27)28/h3-11,14,18-21,25H,12-13H2,1-2H3,(H,24,26)(H,27,28) QVCXXLCPWNJJID-UHFFFAOYSA-N 372268 US20260021085, Compound 16 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 836 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372268 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372268&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254906 402359209 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210380 O=C(O)[C@H]1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C23H24FNO3/c24-20-13-16(11-12-17(20)14-9-10-14)21(15-5-2-1-3-6-15)25-22(26)18-7-4-8-19(18)23(27)28/h1-3,5-6,11-14,18-19,21H,4,7-10H2,(H,25,26)(H,27,28) YVGCMEKLUKEAAK-UHFFFAOYSA-N 372269 US20260021085, Compound 17 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1582 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372269 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372269&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254477 402359210 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210381 O=C(O)[C@H]1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CCC2)c(F)c1 InChI=1S/C24H26FNO3/c25-21-14-17(12-13-18(21)15-8-4-9-15)22(16-6-2-1-3-7-16)26-23(27)19-10-5-11-20(19)24(28)29/h1-3,6-7,12-15,19-20,22H,4-5,8-11H2,(H,26,27)(H,28,29) BTISGEPOBIBBAE-UHFFFAOYSA-N 372270 US20260021085, Compound 18 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 384 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372270 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372270&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254590 402359211 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210382 CC(C)c1ccc(C(NC(=O)C2CCCC2C(=O)O)c2cccc3[nH]c(=O)[nH]c23)cc1 InChI=1S/C24H27N3O4/c1-13(2)14-9-11-15(12-10-14)20(18-7-4-8-19-21(18)27-24(31)25-19)26-22(28)16-5-3-6-17(16)23(29)30/h4,7-13,16-17,20H,3,5-6H2,1-2H3,(H,26,28)(H,29,30)(H2,25,27,31) UMNBLFVOIBQWNB-UHFFFAOYSA-N 372271 US20260021085, Compound 19 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 228 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372271 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372271&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 171096894 402359212 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210383 CC(C)c1ccc(C(NC(=O)C2CCCC2C(=O)O)c2cccc3[nH]c(=O)[nH]c23)cc1 InChI=1S/C24H27N3O4/c1-13(2)14-9-11-15(12-10-14)20(18-7-4-8-19-21(18)27-24(31)25-19)26-22(28)16-5-3-6-17(16)23(29)30/h4,7-13,16-17,20H,3,5-6H2,1-2H3,(H,26,28)(H,29,30)(H2,25,27,31) UMNBLFVOIBQWNB-UHFFFAOYSA-N 372272 US20260021085, Compound 20 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 2378 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372272 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372272&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 171096894 402359213 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210384 CC(C)c1ccc([C@@H](NC(=O)C2CC(O)CC2C(=O)O)c2ccccc2)cc1 InChI=1S/C23H27NO4/c1-14(2)15-8-10-17(11-9-15)21(16-6-4-3-5-7-16)24-22(26)19-12-18(25)13-20(19)23(27)28/h3-11,14,18-21,25H,12-13H2,1-2H3,(H,24,26)(H,27,28) QVCXXLCPWNJJID-UHFFFAOYSA-N 372273 US20260021085, Compound 21 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1956 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372273 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372273&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132255015 402359214 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210385 Cc1ccccc1[C@H](NC(=O)C1CCC[C@@H]1C(=O)O)c1ccc(C(C)C)cn1 InChI=1S/C23H28N2O3/c1-14(2)16-11-12-20(24-13-16)21(17-8-5-4-7-15(17)3)25-22(26)18-9-6-10-19(18)23(27)28/h4-5,7-8,11-14,18-19,21H,6,9-10H2,1-3H3,(H,25,26)(H,27,28) BVWYWOYVDWVHIG-UHFFFAOYSA-N 372274 US20260021085, Compound 22 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1265 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372274 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372274&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254982 402359215 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210386 Cc1ccccc1[C@H](NC(=O)[C@@H]1CCC[C@@H]1C(=O)O)c1ccc(C(C)C)c(F)c1 InChI=1S/C24H28FNO3/c1-14(2)17-12-11-16(13-21(17)25)22(18-8-5-4-7-15(18)3)26-23(27)19-9-6-10-20(19)24(28)29/h4-5,7-8,11-14,19-20,22H,6,9-10H2,1-3H3,(H,26,27)(H,28,29) PYMATKGANSUSBD-UHFFFAOYSA-N 372275 Synthesis of (1S,2R)-2-(((R)-(3-fluoro-4-isopropylphenyl)(o-tolyl)methyl)carbamoyl)cyclopentane-1-carboxylic acid ::US20260021085, Compound 23 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 166 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372275 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372275&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254822 402359216 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210387 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccccc2NC(N)=O)cc1F InChI=1S/C24H28FN3O4/c1-13(2)15-11-10-14(12-19(15)25)21(18-6-3-4-9-20(18)27-24(26)32)28-22(29)16-7-5-8-17(16)23(30)31/h3-4,6,9-13,16-17,21H,5,7-8H2,1-2H3,(H,28,29)(H,30,31)(H3,26,27,32) YSXSRZSGXGEVAM-UHFFFAOYSA-N 372276 US20260021085, Compound 24 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 2823 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372276 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372276&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254864 402359217 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210388 CC(C)c1ccc([C@@H](NC(=O)C2CC(F)CC2C(=O)O)c2ccccc2)cc1 InChI=1S/C23H26FNO3/c1-14(2)15-8-10-17(11-9-15)21(16-6-4-3-5-7-16)25-22(26)19-12-18(24)13-20(19)23(27)28/h3-11,14,18-21H,12-13H2,1-2H3,(H,25,26)(H,27,28) YHRDPFOKXKLBPW-UHFFFAOYSA-N 372278 US20260021085, Compound 25 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1147 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372278&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254607 402359219 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210389 Cc1ccccc1[C@H](NC(=O)[C@@H]1CCC[C@@H]1C(=O)O)c1ccc(C2CC2)cc1 InChI=1S/C24H27NO3/c1-15-5-2-3-6-19(15)22(18-13-11-17(12-14-18)16-9-10-16)25-23(26)20-7-4-8-21(20)24(27)28/h2-3,5-6,11-14,16,20-22H,4,7-10H2,1H3,(H,25,26)(H,27,28) INXWSTQBMABJED-UHFFFAOYSA-N 372279 US20260021085, Compound 26 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 795 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372279 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372279&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254550 402359220 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210390 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccn[nH]2)cc1F InChI=1S/C20H24FN3O3/c1-11(2)13-7-6-12(10-16(13)21)18(17-8-9-22-24-17)23-19(25)14-4-3-5-15(14)20(26)27/h6-11,14-15,18H,3-5H2,1-2H3,(H,22,24)(H,23,25)(H,26,27) GHDPGFAZUYCRBI-UHFFFAOYSA-N 372280 US20260021085, Compound 27 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1478 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372280 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372280&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 171096854 402359221 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210391 Cc1ccccc1[C@H](NC(=O)[C@@H]1CCC[C@@H]1C(=O)O)c1ccc(C2CCC2)cc1 InChI=1S/C25H29NO3/c1-16-6-2-3-9-20(16)23(19-14-12-18(13-15-19)17-7-4-8-17)26-24(27)21-10-5-11-22(21)25(28)29/h2-3,6,9,12-15,17,21-23H,4-5,7-8,10-11H2,1H3,(H,26,27)(H,28,29) NGZHRLQKDOTEEF-UHFFFAOYSA-N 372281 US20260021085, Compound 28 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 224 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372281 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372281&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254853 402359222 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210392 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccnc2N)cc1 InChI=1S/C22H27N3O3/c1-13(2)14-8-10-15(11-9-14)19(18-7-4-12-24-20(18)23)25-21(26)16-5-3-6-17(16)22(27)28/h4,7-13,16-17,19H,3,5-6H2,1-2H3,(H2,23,24)(H,25,26)(H,27,28) PWMLELPIPYSMLJ-UHFFFAOYSA-N 372282 US20260021085, Compound 29 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1516 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372282 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372282&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254453 402359223 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210393 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccc3c2NC(=O)C3)cc1 InChI=1S/C25H28N2O4/c1-14(2)15-9-11-16(12-10-15)22(20-8-3-5-17-13-21(28)26-23(17)20)27-24(29)18-6-4-7-19(18)25(30)31/h3,5,8-12,14,18-19,22H,4,6-7,13H2,1-2H3,(H,26,28)(H,27,29)(H,30,31) XTJJOGJPBRPBFV-UHFFFAOYSA-N 372284 US20260021085, Compound 30 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1606 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372284 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372284&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254846 402359225 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210394 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccc3c2NC(=O)CC3)cc1 InChI=1S/C26H30N2O4/c1-15(2)16-9-11-18(12-10-16)24(28-25(30)19-6-4-7-20(19)26(31)32)21-8-3-5-17-13-14-22(29)27-23(17)21/h3,5,8-12,15,19-20,24H,4,6-7,13-14H2,1-2H3,(H,27,29)(H,28,30)(H,31,32) MNHMTHBKXKPLOK-UHFFFAOYSA-N 372285 US20260021085, Compound 31 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1086 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372285 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372285&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254800 402359226 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210395 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccn[nH]2)cc1 InChI=1S/C20H25N3O3/c1-12(2)13-6-8-14(9-7-13)18(17-10-11-21-23-17)22-19(24)15-4-3-5-16(15)20(25)26/h6-12,15-16,18H,3-5H2,1-2H3,(H,21,23)(H,22,24)(H,25,26) RDTZHFLCIRFHQR-UHFFFAOYSA-N 372286 US20260021085, Compound 32 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 2392 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372286 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372286&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 171096856 402359227 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210396 CC(C)c1ccc([C@@H](NC(=O)C2CCC(C(=O)O)C2)c2ccccc2)cc1 InChI=1S/C23H27NO3/c1-15(2)16-8-10-18(11-9-16)21(17-6-4-3-5-7-17)24-22(25)19-12-13-20(14-19)23(26)27/h3-11,15,19-21H,12-14H2,1-2H3,(H,24,25)(H,26,27) MKGYLKCZGMWKOZ-UHFFFAOYSA-N 372287 US20260021085, Compound 33 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 3128 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372287 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372287&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132255043 402359228 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210397 O=C(O)[C@H]1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CCC2)cc1 InChI=1S/C24H27NO3/c26-23(20-10-5-11-21(20)24(27)28)25-22(18-6-2-1-3-7-18)19-14-12-17(13-15-19)16-8-4-9-16/h1-3,6-7,12-16,20-22H,4-5,8-11H2,(H,25,26)(H,27,28) YIBQHYUQTMWUGD-UHFFFAOYSA-N 372288 US20260021085, Compound 34 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 426 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372288 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372288&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254877 402359229 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210398 CC1(C)CC2(CC([C@@H](NC(=O)C3CCCC3C(=O)O)c3ccccc3)C2)C1 InChI=1S/C23H31NO3/c1-22(2)13-23(14-22)11-16(12-23)19(15-7-4-3-5-8-15)24-20(25)17-9-6-10-18(17)21(26)27/h3-5,7-8,16-19H,6,9-14H2,1-2H3,(H,24,25)(H,26,27) NCSPJEKNHBEOKL-UHFFFAOYSA-N 372289 US20260021085, Compound 35 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 2395 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372289 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372289&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254886 402359230 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210399 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccccc2)nc1 InChI=1S/C22H26N2O3/c1-14(2)16-11-12-19(23-13-16)20(15-7-4-3-5-8-15)24-21(25)17-9-6-10-18(17)22(26)27/h3-5,7-8,11-14,17-18,20H,6,9-10H2,1-2H3,(H,24,25)(H,26,27) FPFVDDSBSLNSKX-UHFFFAOYSA-N 372290 US20260021085, Compound 36 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 837 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372290 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372290&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254368 402359231 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210400 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccccc2)cc1F InChI=1S/C23H26FNO3/c1-14(2)17-12-11-16(13-20(17)24)21(15-7-4-3-5-8-15)25-22(26)18-9-6-10-19(18)23(27)28/h3-5,7-8,11-14,18-19,21H,6,9-10H2,1-2H3,(H,25,26)(H,27,28) RUPGYZNZYJJFEL-UHFFFAOYSA-N 372291 US20260021085, Compound 37 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 236 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372291 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372291&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254485 402359232 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210401 O=C(O)[C@H]1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)cc1 InChI=1S/C23H25NO3/c25-22(19-7-4-8-20(19)23(26)27)24-21(17-5-2-1-3-6-17)18-13-11-16(12-14-18)15-9-10-15/h1-3,5-6,11-15,19-21H,4,7-10H2,(H,24,25)(H,26,27) AKNVQPUZRBGOHR-UHFFFAOYSA-N 372292 US20260021085, Compound 38 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 1129 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372292 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372292&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254629 402359233 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210402 COc1ccccc1[C@H](NC(=O)[C@@H]1CCC[C@@H]1C(=O)O)c1ccc(C(C)C)cc1 InChI=1S/C24H29NO4/c1-15(2)16-11-13-17(14-12-16)22(20-7-4-5-10-21(20)29-3)25-23(26)18-8-6-9-19(18)24(27)28/h4-5,7,10-15,18-19,22H,6,8-9H2,1-3H3,(H,25,26)(H,27,28) IQTMENNECLRHHK-UHFFFAOYSA-N 372293 US20260021085, Compound 39 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 3405 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372293 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372293&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254513 402359234 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210403 Cc1ccccc1[C@H](NC(=O)[C@@H]1CCC[C@@H]1C(=O)O)c1ccc(C(C)C)cc1 InChI=1S/C24H29NO3/c1-15(2)17-11-13-18(14-12-17)22(19-8-5-4-7-16(19)3)25-23(26)20-9-6-10-21(20)24(27)28/h4-5,7-8,11-15,20-22H,6,9-10H2,1-3H3,(H,25,26)(H,27,28) ORMGJIIYUXHIMF-UHFFFAOYSA-N 372294 US20260021085, Compound 40 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 390 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372294 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372294&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254619 402359235 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210404 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccccc2)cc1 InChI=1S/C23H27NO3/c1-15(2)16-11-13-18(14-12-16)21(17-7-4-3-5-8-17)24-22(25)19-9-6-10-20(19)23(26)27/h3-5,7-8,11-15,19-21H,6,9-10H2,1-2H3,(H,24,25)(H,26,27) CWIGUJQUUQGHLW-UHFFFAOYSA-N 372295 US20260021085, Compound 41 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 637 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372295 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372295&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254767 402359236 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210405 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCCC[C@@H]2C(=O)O)c2cccs2)cc1 InChI=1S/C22H27NO3S/c1-14(2)15-9-11-16(12-10-15)20(19-8-5-13-27-19)23-21(24)17-6-3-4-7-18(17)22(25)26/h5,8-14,17-18,20H,3-4,6-7H2,1-2H3,(H,23,24)(H,25,26) BKCQXWDFLCLUKQ-UHFFFAOYSA-N 372296 US20260021085, Compound 42 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 961 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372296 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372296&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254520 402359237 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210406 CC(C)c1ccc(C(NC(=O)C2CCCC2C(=O)O)c2cccs2)cc1 InChI=1S/C21H25NO3S/c1-13(2)14-8-10-15(11-9-14)19(18-7-4-12-26-18)22-20(23)16-5-3-6-17(16)21(24)25/h4,7-13,16-17,19H,3,5-6H2,1-2H3,(H,22,23)(H,24,25) LMXAKSVYHUKYGJ-UHFFFAOYSA-N 372297 US20260021085, Compound 43 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 19750 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372297 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372297&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254753 402359238 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210407 CC(C)c1ccc(C(NC(=O)C2CCCC2C(=O)O)c2cccs2)cc1 InChI=1S/C21H25NO3S/c1-13(2)14-8-10-15(11-9-14)19(18-7-4-12-26-18)22-20(23)16-5-3-6-17(16)21(24)25/h4,7-13,16-17,19H,3,5-6H2,1-2H3,(H,22,23)(H,24,25) LMXAKSVYHUKYGJ-UHFFFAOYSA-N 372298 US20260021085, Compound 44 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 12870 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372298 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372298&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254865 402359239 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210408 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccs2)cc1 InChI=1S/C21H25NO3S/c1-13(2)14-8-10-15(11-9-14)19(18-7-4-12-26-18)22-20(23)16-5-3-6-17(16)21(24)25/h4,7-13,16-17,19H,3,5-6H2,1-2H3,(H,22,23)(H,24,25) LMXAKSVYHUKYGJ-UHFFFAOYSA-N 372299 US20260021085, Compound 45 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens 364 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372299 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372299&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254775 402359240 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210409 CC(C)c1ccc(C(NC(=O)C2CCCC2C(=O)O)c2cccs2)cc1 InChI=1S/C21H25NO3S/c1-13(2)14-8-10-15(11-9-14)19(18-7-4-12-26-18)22-20(23)16-5-3-6-17(16)21(24)25/h4,7-13,16-17,19H,3,5-6H2,1-2H3,(H,22,23)(H,24,25) LMXAKSVYHUKYGJ-UHFFFAOYSA-N 372300 US20260021085, Compound 46 Glycogen [starch] synthase, muscle/Glycogenin-1 (GN1) Homo sapiens >99880 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372300 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=495&target=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372300&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+muscle%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254495 402359241 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN 8Z0A,7ZBN,7Q13,7Q12,7Q0S,7Q0B Glycogen [starch] synthase, muscle GYS1_HUMAN P13807 Q9BTT9 210410 CC(C)c1c(F)cc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccccc2)cc1F InChI=1S/C23H25F2NO3/c1-13(2)20-18(24)11-15(12-19(20)25)21(14-7-4-3-5-8-14)26-22(27)16-9-6-10-17(16)23(28)29/h3-5,7-8,11-13,16-17,21H,6,9-10H2,1-2H3,(H,26,27)(H,28,29) UUWBMPQOKMJUIE-UHFFFAOYSA-N 372260 US20260021085, Compound 8 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens >100000 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372260 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372260&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254659 402359201 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210411 O=C(O)[C@H]1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CCC2)cn1 InChI=1S/C23H26N2O3/c26-22(18-10-5-11-19(18)23(27)28)25-21(16-6-2-1-3-7-16)20-13-12-17(14-24-20)15-8-4-9-15/h1-3,6-7,12-15,18-19,21H,4-5,8-11H2,(H,25,26)(H,27,28) DPTBRBMOFOJDPQ-UHFFFAOYSA-N 372267 US20260021085, Compound 15 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens >100000 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372267 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372267&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254706 402359208 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210412 O=C(O)[C@H]1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C23H24FNO3/c24-20-13-16(11-12-17(20)14-9-10-14)21(15-5-2-1-3-6-15)25-22(26)18-7-4-8-19(18)23(27)28/h1-3,5-6,11-14,18-19,21H,4,7-10H2,(H,25,26)(H,27,28) YVGCMEKLUKEAAK-UHFFFAOYSA-N 372269 US20260021085, Compound 17 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens >100000 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372269 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372269&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254477 402359210 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210413 O=C(O)[C@H]1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CCC2)c(F)c1 InChI=1S/C24H26FNO3/c25-21-14-17(12-13-18(21)15-8-4-9-15)22(16-6-2-1-3-7-16)26-23(27)19-10-5-11-20(19)24(28)29/h1-3,6-7,12-15,19-20,22H,4-5,8-11H2,(H,26,27)(H,28,29) BTISGEPOBIBBAE-UHFFFAOYSA-N 372270 US20260021085, Compound 18 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens 28600 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372270 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372270&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254590 402359211 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210414 CC(C)c1ccc(C(NC(=O)C2CCCC2C(=O)O)c2cccc3[nH]c(=O)[nH]c23)cc1 InChI=1S/C24H27N3O4/c1-13(2)14-9-11-15(12-10-14)20(18-7-4-8-19-21(18)27-24(31)25-19)26-22(28)16-5-3-6-17(16)23(29)30/h4,7-13,16-17,20H,3,5-6H2,1-2H3,(H,26,28)(H,29,30)(H2,25,27,31) UMNBLFVOIBQWNB-UHFFFAOYSA-N 372271 US20260021085, Compound 19 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens >100000 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372271 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372271&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 171096894 402359212 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210415 Cc1ccccc1[C@H](NC(=O)C1CCC[C@@H]1C(=O)O)c1ccc(C(C)C)cn1 InChI=1S/C23H28N2O3/c1-14(2)16-11-12-20(24-13-16)21(17-8-5-4-7-15(17)3)25-22(26)18-9-6-10-19(18)23(27)28/h4-5,7-8,11-14,18-19,21H,6,9-10H2,1-3H3,(H,25,26)(H,27,28) BVWYWOYVDWVHIG-UHFFFAOYSA-N 372274 US20260021085, Compound 22 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens 66730 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372274 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372274&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254982 402359215 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210416 Cc1ccccc1[C@H](NC(=O)[C@@H]1CCC[C@@H]1C(=O)O)c1ccc(C(C)C)c(F)c1 InChI=1S/C24H28FNO3/c1-14(2)17-12-11-16(13-21(17)25)22(18-8-5-4-7-15(18)3)26-23(27)19-9-6-10-20(19)24(28)29/h4-5,7-8,11-14,19-20,22H,6,9-10H2,1-3H3,(H,26,27)(H,28,29) PYMATKGANSUSBD-UHFFFAOYSA-N 372275 Synthesis of (1S,2R)-2-(((R)-(3-fluoro-4-isopropylphenyl)(o-tolyl)methyl)carbamoyl)cyclopentane-1-carboxylic acid ::US20260021085, Compound 23 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens 8483 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372275 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372275&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254822 402359216 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210417 Cc1ccccc1[C@H](NC(=O)[C@@H]1CCC[C@@H]1C(=O)O)c1ccc(C2CC2)cc1 InChI=1S/C24H27NO3/c1-15-5-2-3-6-19(15)22(18-13-11-17(12-14-18)16-9-10-16)25-23(26)20-7-4-8-21(20)24(27)28/h2-3,5-6,11-14,16,20-22H,4,7-10H2,1H3,(H,25,26)(H,27,28) INXWSTQBMABJED-UHFFFAOYSA-N 372279 US20260021085, Compound 26 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens 15490 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372279 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372279&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254550 402359220 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210418 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccn[nH]2)cc1F InChI=1S/C20H24FN3O3/c1-11(2)13-7-6-12(10-16(13)21)18(17-8-9-22-24-17)23-19(25)14-4-3-5-15(14)20(26)27/h6-11,14-15,18H,3-5H2,1-2H3,(H,22,24)(H,23,25)(H,26,27) GHDPGFAZUYCRBI-UHFFFAOYSA-N 372280 US20260021085, Compound 27 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens >100000 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372280 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372280&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 171096854 402359221 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210419 Cc1ccccc1[C@H](NC(=O)[C@@H]1CCC[C@@H]1C(=O)O)c1ccc(C2CCC2)cc1 InChI=1S/C25H29NO3/c1-16-6-2-3-9-20(16)23(19-14-12-18(13-15-19)17-7-4-8-17)26-24(27)21-10-5-11-22(21)25(28)29/h2-3,6,9,12-15,17,21-23H,4-5,7-8,10-11H2,1H3,(H,26,27)(H,28,29) NGZHRLQKDOTEEF-UHFFFAOYSA-N 372281 US20260021085, Compound 28 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens 7797 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372281 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372281&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254853 402359222 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210420 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccc3c2NC(=O)CC3)cc1 InChI=1S/C26H30N2O4/c1-15(2)16-9-11-18(12-10-16)24(28-25(30)19-6-4-7-20(19)26(31)32)21-8-3-5-17-13-14-22(29)27-23(17)21/h3,5,8-12,15,19-20,24H,4,6-7,13-14H2,1-2H3,(H,27,29)(H,28,30)(H,31,32) MNHMTHBKXKPLOK-UHFFFAOYSA-N 372285 US20260021085, Compound 31 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens >100000 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372285 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372285&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254800 402359226 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210421 O=C(O)[C@H]1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CCC2)cc1 InChI=1S/C24H27NO3/c26-23(20-10-5-11-21(20)24(27)28)25-22(18-6-2-1-3-7-18)19-14-12-17(13-15-19)16-8-4-9-16/h1-3,6-7,12-16,20-22H,4-5,8-11H2,(H,25,26)(H,27,28) YIBQHYUQTMWUGD-UHFFFAOYSA-N 372288 US20260021085, Compound 34 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens 67070 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372288 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372288&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254877 402359229 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210422 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccccc2)nc1 InChI=1S/C22H26N2O3/c1-14(2)16-11-12-19(23-13-16)20(15-7-4-3-5-8-15)24-21(25)17-9-6-10-18(17)22(26)27/h3-5,7-8,11-14,17-18,20H,6,9-10H2,1-2H3,(H,24,25)(H,26,27) FPFVDDSBSLNSKX-UHFFFAOYSA-N 372290 US20260021085, Compound 36 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens >100000 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372290 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372290&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254368 402359231 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210423 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccccc2)cc1F InChI=1S/C23H26FNO3/c1-14(2)17-12-11-16(13-20(17)24)21(15-7-4-3-5-8-15)25-22(26)18-9-6-10-19(18)23(27)28/h3-5,7-8,11-14,18-19,21H,6,9-10H2,1-2H3,(H,25,26)(H,27,28) RUPGYZNZYJJFEL-UHFFFAOYSA-N 372291 US20260021085, Compound 37 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens 72750 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372291 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372291&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254485 402359232 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210424 COc1ccccc1[C@H](NC(=O)[C@@H]1CCC[C@@H]1C(=O)O)c1ccc(C(C)C)cc1 InChI=1S/C24H29NO4/c1-15(2)16-11-13-17(14-12-16)22(20-7-4-5-10-21(20)29-3)25-23(26)18-8-6-9-19(18)24(27)28/h4-5,7,10-15,18-19,22H,6,8-9H2,1-3H3,(H,25,26)(H,27,28) IQTMENNECLRHHK-UHFFFAOYSA-N 372293 US20260021085, Compound 39 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens 66400 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372293 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372293&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254513 402359234 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210425 Cc1ccccc1[C@H](NC(=O)[C@@H]1CCC[C@@H]1C(=O)O)c1ccc(C(C)C)cc1 InChI=1S/C24H29NO3/c1-15(2)17-11-13-18(14-12-17)22(19-8-5-4-7-16(19)3)25-23(26)20-9-6-10-21(20)24(27)28/h4-5,7-8,11-15,20-22H,6,9-10H2,1-3H3,(H,25,26)(H,27,28) ORMGJIIYUXHIMF-UHFFFAOYSA-N 372294 US20260021085, Compound 40 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens 10780 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372294 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372294&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254619 402359235 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210426 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2ccccc2)cc1 InChI=1S/C23H27NO3/c1-15(2)16-11-13-18(14-12-16)21(17-7-4-3-5-8-17)24-22(25)19-9-6-10-20(19)23(26)27/h3-5,7-8,11-15,19-21H,6,9-10H2,1-2H3,(H,24,25)(H,26,27) CWIGUJQUUQGHLW-UHFFFAOYSA-N 372295 US20260021085, Compound 41 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens >87060 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372295 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372295&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254767 402359236 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210427 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCCC[C@@H]2C(=O)O)c2cccs2)cc1 InChI=1S/C22H27NO3S/c1-14(2)15-9-11-16(12-10-15)20(19-8-5-13-27-19)23-21(24)17-6-3-4-7-18(17)22(25)26/h5,8-14,17-18,20H,3-4,6-7H2,1-2H3,(H,23,24)(H,25,26) BKCQXWDFLCLUKQ-UHFFFAOYSA-N 372296 US20260021085, Compound 42 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens >77600 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372296 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372296&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254520 402359237 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210428 CC(C)c1ccc(C(NC(=O)C2CCCC2C(=O)O)c2cccs2)cc1 InChI=1S/C21H25NO3S/c1-13(2)14-8-10-15(11-9-14)19(18-7-4-12-26-18)22-20(23)16-5-3-6-17(16)21(24)25/h4,7-13,16-17,19H,3,5-6H2,1-2H3,(H,22,23)(H,24,25) LMXAKSVYHUKYGJ-UHFFFAOYSA-N 372297 US20260021085, Compound 43 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens >250000 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372297 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372297&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254753 402359238 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210429 CC(C)c1ccc(C(NC(=O)C2CCCC2C(=O)O)c2cccs2)cc1 InChI=1S/C21H25NO3S/c1-13(2)14-8-10-15(11-9-14)19(18-7-4-12-26-18)22-20(23)16-5-3-6-17(16)21(24)25/h4,7-13,16-17,19H,3,5-6H2,1-2H3,(H,22,23)(H,24,25) LMXAKSVYHUKYGJ-UHFFFAOYSA-N 372298 US20260021085, Compound 44 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens 11690 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372298 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372298&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254865 402359239 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210430 CC(C)c1ccc([C@@H](NC(=O)[C@@H]2CCC[C@@H]2C(=O)O)c2cccs2)cc1 InChI=1S/C21H25NO3S/c1-13(2)14-8-10-15(11-9-14)19(18-7-4-12-26-18)22-20(23)16-5-3-6-17(16)21(24)25/h4,7-13,16-17,19H,3,5-6H2,1-2H3,(H,22,23)(H,24,25) LMXAKSVYHUKYGJ-UHFFFAOYSA-N 372299 US20260021085, Compound 45 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens 97960 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372299 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372299&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254775 402359240 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 210431 CC(C)c1ccc(C(NC(=O)C2CCCC2C(=O)O)c2cccs2)cc1 InChI=1S/C21H25NO3S/c1-13(2)14-8-10-15(11-9-14)19(18-7-4-12-26-18)22-20(23)16-5-3-6-17(16)21(24)25/h4,7-13,16-17,19H,3,5-6H2,1-2H3,(H,22,23)(H,24,25) LMXAKSVYHUKYGJ-UHFFFAOYSA-N 372300 US20260021085, Compound 46 Glycogen [starch] synthase, liver/Glycogenin-1 (GN1) Homo sapiens >250000 US Patent 10.7270/Q25T3R9Q US20260021085 MORGANS, JR., DJ; MELLEM, K; POWERS, HL; LEE, PS; WON, W; SINZ, CJ 1/22/2026 6/3/2026 Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372300 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=496&target=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372300&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver%2FGlycogenin-1+%28GN1%29&column=ki&startPg=0&Increment=50&submit=Search 132254495 402359241 2 MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ 7Q13,7Q12,7Q0S,7Q0B,3U2X,3U2V,3U2U,3T7O,3T7N,3T7M,3U2T,3USQ,7OVX Glycogenin-1 GLYG_HUMAN P46976 D3DNH0 D3DNH1 D3DNH2 Q6FHZ1 Q9UNV0 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8