BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
125704	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H21F3N6O3/c1-33-11-15(10-30-33)12-4-14(9-29)21-18(5-12)32-34(2)23(21)13-6-19(36-3)22(20(7-13)37-25(27)28)24(35)31-17-8-16(17)26/h4-7,10-11,16-17,25H,8H2,1-3H3,(H,31,35)	XPCKRPHZNQBSRC-UHFFFAOYSA-N	794470	US20260062387, Example 1	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794470&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606111	528825933							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125705	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H21F3N6O3/c1-33-11-15(10-30-33)12-4-14(9-29)21-18(5-12)32-34(2)23(21)13-6-19(36-3)22(20(7-13)37-25(27)28)24(35)31-17-8-16(17)26/h4-7,10-11,16-17,25H,8H2,1-3H3,(H,31,35)	XPCKRPHZNQBSRC-UHFFFAOYSA-N	794470	US20260062387, Example 1	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794470&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606111	528825933							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125706	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H21F3N6O3/c1-33-11-15(10-30-33)12-4-14(9-29)21-18(5-12)32-34(2)23(21)13-6-19(36-3)22(20(7-13)37-25(27)28)24(35)31-17-8-16(17)26/h4-7,10-11,16-17,25H,8H2,1-3H3,(H,31,35)	XPCKRPHZNQBSRC-UHFFFAOYSA-N	794470	US20260062387, Example 1	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794470&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606111	528825933							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125707	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H24F3N5O4/c1-32-11-14(10-29-32)12-5-17-21(18(6-12)35-3)23(33(2)31-17)13-7-19(36-4)22(20(8-13)37-25(27)28)24(34)30-16-9-15(16)26/h5-8,10-11,15-16,25H,9H2,1-4H3,(H,30,34)	LIPFGPSWNXWDON-UHFFFAOYSA-N	794471	US20260062387, Example 2	Serine/threonine-protein kinase SIK1	Homo sapiens		 19.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794471&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606043	528825934							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125708	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H24F3N5O4/c1-32-11-14(10-29-32)12-5-17-21(18(6-12)35-3)23(33(2)31-17)13-7-19(36-4)22(20(8-13)37-25(27)28)24(34)30-16-9-15(16)26/h5-8,10-11,15-16,25H,9H2,1-4H3,(H,30,34)	LIPFGPSWNXWDON-UHFFFAOYSA-N	794471	US20260062387, Example 2	Serine/threonine-protein kinase SIK2	Homo sapiens		 8.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794471&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606043	528825934							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125709	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H24F3N5O4/c1-32-11-14(10-29-32)12-5-17-21(18(6-12)35-3)23(33(2)31-17)13-7-19(36-4)22(20(8-13)37-25(27)28)24(34)30-16-9-15(16)26/h5-8,10-11,15-16,25H,9H2,1-4H3,(H,30,34)	LIPFGPSWNXWDON-UHFFFAOYSA-N	794471	US20260062387, Example 2	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794471&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606043	528825934							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125710	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H22F5N5O3/c1-34-10-13(9-31-34)11-4-14(23(27)28)20-17(5-11)33-35(2)22(20)12-6-18(37-3)21(19(7-12)38-25(29)30)24(36)32-16-8-15(16)26/h4-7,9-10,15-16,23,25H,8H2,1-3H3,(H,32,36)	VEIFDAVCCXNQBL-UHFFFAOYSA-N	794472	US20260062387, Example 3	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794472&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606220	528825935							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125711	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H22F5N5O3/c1-34-10-13(9-31-34)11-4-14(23(27)28)20-17(5-11)33-35(2)22(20)12-6-18(37-3)21(19(7-12)38-25(29)30)24(36)32-16-8-15(16)26/h4-7,9-10,15-16,23,25H,8H2,1-3H3,(H,32,36)	VEIFDAVCCXNQBL-UHFFFAOYSA-N	794472	US20260062387, Example 3	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794472&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606220	528825935							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125712	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H22F5N5O3/c1-34-10-13(9-31-34)11-4-14(23(27)28)20-17(5-11)33-35(2)22(20)12-6-18(37-3)21(19(7-12)38-25(29)30)24(36)32-16-8-15(16)26/h4-7,9-10,15-16,23,25H,8H2,1-3H3,(H,32,36)	VEIFDAVCCXNQBL-UHFFFAOYSA-N	794472	US20260062387, Example 3	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794472&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606220	528825935							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125713	COc1cc(-c2c3c(OCCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C27H28F3N5O5/c1-34-13-16(12-31-34)14-7-19-23(21(8-14)39-6-4-5-36)25(35(2)33-19)15-9-20(38-3)24(22(10-15)40-27(29)30)26(37)32-18-11-17(18)28/h7-10,12-13,17-18,27,36H,4-6,11H2,1-3H3,(H,32,37)	BDKQWLJCFAADCM-UHFFFAOYSA-N	794473	US20260062387, Example 4	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794473&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605947	528825936							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125714	COc1cc(-c2c3c(OCCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C27H28F3N5O5/c1-34-13-16(12-31-34)14-7-19-23(21(8-14)39-6-4-5-36)25(35(2)33-19)15-9-20(38-3)24(22(10-15)40-27(29)30)26(37)32-18-11-17(18)28/h7-10,12-13,17-18,27,36H,4-6,11H2,1-3H3,(H,32,37)	BDKQWLJCFAADCM-UHFFFAOYSA-N	794473	US20260062387, Example 4	Serine/threonine-protein kinase SIK2	Homo sapiens		 8.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794473&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605947	528825936							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125715	COc1cc(-c2c3c(OCCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C27H28F3N5O5/c1-34-13-16(12-31-34)14-7-19-23(21(8-14)39-6-4-5-36)25(35(2)33-19)15-9-20(38-3)24(22(10-15)40-27(29)30)26(37)32-18-11-17(18)28/h7-10,12-13,17-18,27,36H,4-6,11H2,1-3H3,(H,32,37)	BDKQWLJCFAADCM-UHFFFAOYSA-N	794473	US20260062387, Example 4	Serine/threonine-protein kinase SIK3	Homo sapiens		 11.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794473&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605947	528825936							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125716	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H22F5N5O4/c1-34-10-13(9-31-34)11-4-16-20(18(5-11)38-24(27)28)22(35(2)33-16)12-6-17(37-3)21(19(7-12)39-25(29)30)23(36)32-15-8-14(15)26/h4-7,9-10,14-15,24-25H,8H2,1-3H3,(H,32,36)	HXOLKMSVCCGXMY-UHFFFAOYSA-N	794474	US20260062387, Example 5	Serine/threonine-protein kinase SIK1	Homo sapiens		 10.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794474&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605976	528825937							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125717	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H22F5N5O4/c1-34-10-13(9-31-34)11-4-16-20(18(5-11)38-24(27)28)22(35(2)33-16)12-6-17(37-3)21(19(7-12)39-25(29)30)23(36)32-15-8-14(15)26/h4-7,9-10,14-15,24-25H,8H2,1-3H3,(H,32,36)	HXOLKMSVCCGXMY-UHFFFAOYSA-N	794474	US20260062387, Example 5	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794474&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605976	528825937							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125718	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H22F5N5O4/c1-34-10-13(9-31-34)11-4-16-20(18(5-11)38-24(27)28)22(35(2)33-16)12-6-17(37-3)21(19(7-12)39-25(29)30)23(36)32-15-8-14(15)26/h4-7,9-10,14-15,24-25H,8H2,1-3H3,(H,32,36)	HXOLKMSVCCGXMY-UHFFFAOYSA-N	794474	US20260062387, Example 5	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794474&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605976	528825937							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125719	COc1cc(-c2c3c(OCc4ccccc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C31H28F3N5O4/c1-38-15-20(14-35-38)18-9-23-27(25(10-18)42-16-17-7-5-4-6-8-17)29(39(2)37-23)19-11-24(41-3)28(26(12-19)43-31(33)34)30(40)36-22-13-21(22)32/h4-12,14-15,21-22,31H,13,16H2,1-3H3,(H,36,40)	YJXZIBBARXGPDE-UHFFFAOYSA-N	794475	US20260062387, Example 6	Serine/threonine-protein kinase SIK1	Homo sapiens		 2.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794475&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605971	528825938							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125720	COc1cc(-c2c3c(OCc4ccccc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C31H28F3N5O4/c1-38-15-20(14-35-38)18-9-23-27(25(10-18)42-16-17-7-5-4-6-8-17)29(39(2)37-23)19-11-24(41-3)28(26(12-19)43-31(33)34)30(40)36-22-13-21(22)32/h4-12,14-15,21-22,31H,13,16H2,1-3H3,(H,36,40)	YJXZIBBARXGPDE-UHFFFAOYSA-N	794475	US20260062387, Example 6	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794475&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605971	528825938							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125721	COc1cc(-c2c3c(OCc4ccccc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C31H28F3N5O4/c1-38-15-20(14-35-38)18-9-23-27(25(10-18)42-16-17-7-5-4-6-8-17)29(39(2)37-23)19-11-24(41-3)28(26(12-19)43-31(33)34)30(40)36-22-13-21(22)32/h4-12,14-15,21-22,31H,13,16H2,1-3H3,(H,36,40)	YJXZIBBARXGPDE-UHFFFAOYSA-N	794475	US20260062387, Example 6	Serine/threonine-protein kinase SIK3	Homo sapiens		 8.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794475&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605971	528825938							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125722	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H21F5N6O4/c1-35-10-16(9-33-35)13-4-15(8-32)20-17(5-13)34-36(2)22(20)14-6-18(40-3)21(19(7-14)41-24(27)28)23(38)37-11-25(39,12-37)26(29,30)31/h4-7,9-10,24,39H,11-12H2,1-3H3	RECSITHFLWGQSX-UHFFFAOYSA-N	794476	US20260062387, Example 7	Serine/threonine-protein kinase SIK1	Homo sapiens		 17.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794476&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606109	528825939							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125723	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H21F5N6O4/c1-35-10-16(9-33-35)13-4-15(8-32)20-17(5-13)34-36(2)22(20)14-6-18(40-3)21(19(7-14)41-24(27)28)23(38)37-11-25(39,12-37)26(29,30)31/h4-7,9-10,24,39H,11-12H2,1-3H3	RECSITHFLWGQSX-UHFFFAOYSA-N	794476	US20260062387, Example 7	Serine/threonine-protein kinase SIK2	Homo sapiens		 16.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794476&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606109	528825939							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125724	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H21F5N6O4/c1-35-10-16(9-33-35)13-4-15(8-32)20-17(5-13)34-36(2)22(20)14-6-18(40-3)21(19(7-14)41-24(27)28)23(38)37-11-25(39,12-37)26(29,30)31/h4-7,9-10,24,39H,11-12H2,1-3H3	RECSITHFLWGQSX-UHFFFAOYSA-N	794476	US20260062387, Example 7	Serine/threonine-protein kinase SIK3	Homo sapiens		 12.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794476&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606109	528825939							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125725	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(C)(C(F)F)C1	InChI=1S/C27H24F4N6O3/c1-27(25(28)29)12-37(13-27)24(38)22-19(39-4)7-15(8-20(22)40-26(30)31)23-21-16(9-32)5-14(6-18(21)34-36(23)3)17-10-33-35(2)11-17/h5-8,10-11,25-26H,12-13H2,1-4H3	HIHHTZWYBCUGLM-UHFFFAOYSA-N	794477	US20260062387, Example 8	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794477&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605972	528825940							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125726	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(C)(C(F)F)C1	InChI=1S/C27H24F4N6O3/c1-27(25(28)29)12-37(13-27)24(38)22-19(39-4)7-15(8-20(22)40-26(30)31)23-21-16(9-32)5-14(6-18(21)34-36(23)3)17-10-33-35(2)11-17/h5-8,10-11,25-26H,12-13H2,1-4H3	HIHHTZWYBCUGLM-UHFFFAOYSA-N	794477	US20260062387, Example 8	Serine/threonine-protein kinase SIK2	Homo sapiens		 9.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794477&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605972	528825940							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125727	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(C)(C(F)F)C1	InChI=1S/C27H24F4N6O3/c1-27(25(28)29)12-37(13-27)24(38)22-19(39-4)7-15(8-20(22)40-26(30)31)23-21-16(9-32)5-14(6-18(21)34-36(23)3)17-10-33-35(2)11-17/h5-8,10-11,25-26H,12-13H2,1-4H3	HIHHTZWYBCUGLM-UHFFFAOYSA-N	794477	US20260062387, Example 8	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794477&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605972	528825940							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125728	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(OC(F)F)C1	InChI=1S/C26H22F4N6O4/c1-34-10-16(9-32-34)13-4-15(8-31)21-18(5-13)33-35(2)23(21)14-6-19(38-3)22(20(7-14)40-26(29)30)24(37)36-11-17(12-36)39-25(27)28/h4-7,9-10,17,25-26H,11-12H2,1-3H3	MPBYBCBEDSJDHU-UHFFFAOYSA-N	794478	US20260062387, Example 9	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794478&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605989	528825941							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125729	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(OC(F)F)C1	InChI=1S/C26H22F4N6O4/c1-34-10-16(9-32-34)13-4-15(8-31)21-18(5-13)33-35(2)23(21)14-6-19(38-3)22(20(7-14)40-26(29)30)24(37)36-11-17(12-36)39-25(27)28/h4-7,9-10,17,25-26H,11-12H2,1-3H3	MPBYBCBEDSJDHU-UHFFFAOYSA-N	794478	US20260062387, Example 9	Serine/threonine-protein kinase SIK2	Homo sapiens		 12.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794478&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605989	528825941							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125730	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(OC(F)F)C1	InChI=1S/C26H22F4N6O4/c1-34-10-16(9-32-34)13-4-15(8-31)21-18(5-13)33-35(2)23(21)14-6-19(38-3)22(20(7-14)40-26(29)30)24(37)36-11-17(12-36)39-25(27)28/h4-7,9-10,17,25-26H,11-12H2,1-3H3	MPBYBCBEDSJDHU-UHFFFAOYSA-N	794478	US20260062387, Example 9	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794478&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605989	528825941							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125731	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1CC1(F)F	InChI=1S/C26H22F4N6O3/c1-35-12-16(10-33-35)13-4-15(9-31)21-18(5-13)34-36(2)23(21)14-6-19(38-3)22(20(7-14)39-25(27)28)24(37)32-11-17-8-26(17,29)30/h4-7,10,12,17,25H,8,11H2,1-3H3,(H,32,37)	ZQURDMWPUBWHNV-UHFFFAOYSA-N	794479	US20260062387, Example 10	Serine/threonine-protein kinase SIK1	Homo sapiens		 13.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794479&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606114	528825942							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125732	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1CC1(F)F	InChI=1S/C26H22F4N6O3/c1-35-12-16(10-33-35)13-4-15(9-31)21-18(5-13)34-36(2)23(21)14-6-19(38-3)22(20(7-14)39-25(27)28)24(37)32-11-17-8-26(17,29)30/h4-7,10,12,17,25H,8,11H2,1-3H3,(H,32,37)	ZQURDMWPUBWHNV-UHFFFAOYSA-N	794479	US20260062387, Example 10	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794479&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606114	528825942							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125733	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1CC1(F)F	InChI=1S/C26H22F4N6O3/c1-35-12-16(10-33-35)13-4-15(9-31)21-18(5-13)34-36(2)23(21)14-6-19(38-3)22(20(7-14)39-25(27)28)24(37)32-11-17-8-26(17,29)30/h4-7,10,12,17,25H,8,11H2,1-3H3,(H,32,37)	ZQURDMWPUBWHNV-UHFFFAOYSA-N	794479	US20260062387, Example 10	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794479&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606114	528825942							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125734	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C25H21F6N5O3/c1-35-10-13(9-32-35)11-4-14(22(26)27)19-15(5-11)34-36(2)21(19)12-6-16(38-3)20(17(7-12)39-24(28)29)23(37)33-18-8-25(18,30)31/h4-7,9-10,18,22,24H,8H2,1-3H3,(H,33,37)	PGZOKNVRIJBGGX-UHFFFAOYSA-N	794480	US20260062387, Example 11	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794480&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606046	528825943							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125735	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C25H21F6N5O3/c1-35-10-13(9-32-35)11-4-14(22(26)27)19-15(5-11)34-36(2)21(19)12-6-16(38-3)20(17(7-12)39-24(28)29)23(37)33-18-8-25(18,30)31/h4-7,9-10,18,22,24H,8H2,1-3H3,(H,33,37)	PGZOKNVRIJBGGX-UHFFFAOYSA-N	794480	US20260062387, Example 11	Serine/threonine-protein kinase SIK2	Homo sapiens		 12.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794480&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606046	528825943							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125736	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C25H21F6N5O3/c1-35-10-13(9-32-35)11-4-14(22(26)27)19-15(5-11)34-36(2)21(19)12-6-16(38-3)20(17(7-12)39-24(28)29)23(37)33-18-8-25(18,30)31/h4-7,9-10,18,22,24H,8H2,1-3H3,(H,33,37)	PGZOKNVRIJBGGX-UHFFFAOYSA-N	794480	US20260062387, Example 11	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794480&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606046	528825943							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125737	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C26H23F3N6O3/c1-34-12-17(11-32-34)14-6-16(10-30)21-18(7-14)33-35(2)23(21)15-8-19(37-3)22(20(9-15)38-25(27)28)24(36)31-13-26(29)4-5-26/h6-9,11-12,25H,4-5,13H2,1-3H3,(H,31,36)	XHJUGFXDMDPFNJ-UHFFFAOYSA-N	794481	US20260062387, Example 12	Serine/threonine-protein kinase SIK1	Homo sapiens		 12.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794481&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605935	528825944							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125738	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C26H23F3N6O3/c1-34-12-17(11-32-34)14-6-16(10-30)21-18(7-14)33-35(2)23(21)15-8-19(37-3)22(20(9-15)38-25(27)28)24(36)31-13-26(29)4-5-26/h6-9,11-12,25H,4-5,13H2,1-3H3,(H,31,36)	XHJUGFXDMDPFNJ-UHFFFAOYSA-N	794481	US20260062387, Example 12	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794481&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605935	528825944							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125739	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C26H23F3N6O3/c1-34-12-17(11-32-34)14-6-16(10-30)21-18(7-14)33-35(2)23(21)15-8-19(37-3)22(20(9-15)38-25(27)28)24(36)31-13-26(29)4-5-26/h6-9,11-12,25H,4-5,13H2,1-3H3,(H,31,36)	XHJUGFXDMDPFNJ-UHFFFAOYSA-N	794481	US20260062387, Example 12	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794481&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605935	528825944							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125740	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H24F5N5O5/c1-34-10-15(9-32-34)13-5-16-20(17(6-13)39-3)22(35(2)33-16)14-7-18(40-4)21(19(8-14)41-24(27)28)23(37)36-11-25(38,12-36)26(29,30)31/h5-10,24,38H,11-12H2,1-4H3	FVHDANMZHPAIIM-UHFFFAOYSA-N	794482	US20260062387, Example 13	Serine/threonine-protein kinase SIK1	Homo sapiens		 4.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794482&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606055	528825945							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125741	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H24F5N5O5/c1-34-10-15(9-32-34)13-5-16-20(17(6-13)39-3)22(35(2)33-16)14-7-18(40-4)21(19(8-14)41-24(27)28)23(37)36-11-25(38,12-36)26(29,30)31/h5-10,24,38H,11-12H2,1-4H3	FVHDANMZHPAIIM-UHFFFAOYSA-N	794482	US20260062387, Example 13	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794482&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606055	528825945							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125742	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H24F5N5O5/c1-34-10-15(9-32-34)13-5-16-20(17(6-13)39-3)22(35(2)33-16)14-7-18(40-4)21(19(8-14)41-24(27)28)23(37)36-11-25(38,12-36)26(29,30)31/h5-10,24,38H,11-12H2,1-4H3	FVHDANMZHPAIIM-UHFFFAOYSA-N	794482	US20260062387, Example 13	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794482&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606055	528825945							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125743	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H22F7N5O5/c1-36-9-14(8-34-36)12-4-15-19(17(5-12)42-23(27)28)21(37(2)35-15)13-6-16(41-3)20(18(7-13)43-24(29)30)22(39)38-10-25(40,11-38)26(31,32)33/h4-9,23-24,40H,10-11H2,1-3H3	ZTPHSLFBLSONKB-UHFFFAOYSA-N	794483	US20260062387, Example 14	Serine/threonine-protein kinase SIK1	Homo sapiens		 3.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794483&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606075	528825946							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125744	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H22F7N5O5/c1-36-9-14(8-34-36)12-4-15-19(17(5-12)42-23(27)28)21(37(2)35-15)13-6-16(41-3)20(18(7-13)43-24(29)30)22(39)38-10-25(40,11-38)26(31,32)33/h4-9,23-24,40H,10-11H2,1-3H3	ZTPHSLFBLSONKB-UHFFFAOYSA-N	794483	US20260062387, Example 14	Serine/threonine-protein kinase SIK2	Homo sapiens		 8.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794483&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606075	528825946							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125745	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H22F7N5O5/c1-36-9-14(8-34-36)12-4-15-19(17(5-12)42-23(27)28)21(37(2)35-15)13-6-16(41-3)20(18(7-13)43-24(29)30)22(39)38-10-25(40,11-38)26(31,32)33/h4-9,23-24,40H,10-11H2,1-3H3	ZTPHSLFBLSONKB-UHFFFAOYSA-N	794483	US20260062387, Example 14	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794483&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606075	528825946							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125746	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(=O)N5CC(O)(C(F)(F)F)C5)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C27H23F5N6O4/c1-4-38-11-17(10-34-38)14-5-16(9-33)21-18(6-14)35-36(2)23(21)15-7-19(41-3)22(20(8-15)42-25(28)29)24(39)37-12-26(40,13-37)27(30,31)32/h5-8,10-11,25,40H,4,12-13H2,1-3H3	USWJCANPOMJLQF-UHFFFAOYSA-N	794484	US20260062387, Example 15	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794484&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606039	528825947							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125747	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(=O)N5CC(O)(C(F)(F)F)C5)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C27H23F5N6O4/c1-4-38-11-17(10-34-38)14-5-16(9-33)21-18(6-14)35-36(2)23(21)15-7-19(41-3)22(20(8-15)42-25(28)29)24(39)37-12-26(40,13-37)27(30,31)32/h5-8,10-11,25,40H,4,12-13H2,1-3H3	USWJCANPOMJLQF-UHFFFAOYSA-N	794484	US20260062387, Example 15	Serine/threonine-protein kinase SIK2	Homo sapiens		 10.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794484&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606039	528825947							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125748	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(=O)N5CC(O)(C(F)(F)F)C5)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C27H23F5N6O4/c1-4-38-11-17(10-34-38)14-5-16(9-33)21-18(6-14)35-36(2)23(21)15-7-19(41-3)22(20(8-15)42-25(28)29)24(39)37-12-26(40,13-37)27(30,31)32/h5-8,10-11,25,40H,4,12-13H2,1-3H3	USWJCANPOMJLQF-UHFFFAOYSA-N	794484	US20260062387, Example 15	Serine/threonine-protein kinase SIK3	Homo sapiens		 1.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794484&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606039	528825947							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125749	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H27F5N6O5/c1-27(2,42)12-40-11-18(10-36-40)15-5-17(9-35)22-19(6-15)37-38(3)24(22)16-7-20(44-4)23(21(8-16)45-26(30)31)25(41)39-13-28(43,14-39)29(32,33)34/h5-8,10-11,26,42-43H,12-14H2,1-4H3	WDFXSWDKBSNGBT-UHFFFAOYSA-N	794485	US20260062387, Example 16	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794485&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606023	528825948							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125750	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H27F5N6O5/c1-27(2,42)12-40-11-18(10-36-40)15-5-17(9-35)22-19(6-15)37-38(3)24(22)16-7-20(44-4)23(21(8-16)45-26(30)31)25(41)39-13-28(43,14-39)29(32,33)34/h5-8,10-11,26,42-43H,12-14H2,1-4H3	WDFXSWDKBSNGBT-UHFFFAOYSA-N	794485	US20260062387, Example 16	Serine/threonine-protein kinase SIK2	Homo sapiens		 13.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794485&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606023	528825948							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125751	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H27F5N6O5/c1-27(2,42)12-40-11-18(10-36-40)15-5-17(9-35)22-19(6-15)37-38(3)24(22)16-7-20(44-4)23(21(8-16)45-26(30)31)25(41)39-13-28(43,14-39)29(32,33)34/h5-8,10-11,26,42-43H,12-14H2,1-4H3	WDFXSWDKBSNGBT-UHFFFAOYSA-N	794485	US20260062387, Example 16	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794485&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606023	528825948							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125752	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H26F5N7O5/c1-38(2)22(42)12-41-11-18(10-36-41)15-5-17(9-35)23-19(6-15)37-39(3)25(23)16-7-20(45-4)24(21(8-16)46-27(30)31)26(43)40-13-28(44,14-40)29(32,33)34/h5-8,10-11,27,44H,12-14H2,1-4H3	VWRDVVPWZGRQLK-UHFFFAOYSA-N	794486	US20260062387, Example 17	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794486&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606010	528825949							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125753	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H26F5N7O5/c1-38(2)22(42)12-41-11-18(10-36-41)15-5-17(9-35)23-19(6-15)37-39(3)25(23)16-7-20(45-4)24(21(8-16)46-27(30)31)26(43)40-13-28(44,14-40)29(32,33)34/h5-8,10-11,27,44H,12-14H2,1-4H3	VWRDVVPWZGRQLK-UHFFFAOYSA-N	794486	US20260062387, Example 17	Serine/threonine-protein kinase SIK2	Homo sapiens		 8.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794486&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606010	528825949							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125754	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H26F5N7O5/c1-38(2)22(42)12-41-11-18(10-36-41)15-5-17(9-35)23-19(6-15)37-39(3)25(23)16-7-20(45-4)24(21(8-16)46-27(30)31)26(43)40-13-28(44,14-40)29(32,33)34/h5-8,10-11,27,44H,12-14H2,1-4H3	VWRDVVPWZGRQLK-UHFFFAOYSA-N	794486	US20260062387, Example 17	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794486&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606010	528825949							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125755	C#Cc1cc(-c2cnn(CC)c2)cc2nn(C)c(-c3cc(OC)c(C(=O)N[C@@H]4C[C@@H]4F)c(OC(F)F)c3)c12	InChI=1S/C27H24F3N5O3/c1-5-14-7-15(17-12-31-35(6-2)13-17)8-20-23(14)25(34(3)33-20)16-9-21(37-4)24(22(10-16)38-27(29)30)26(36)32-19-11-18(19)28/h1,7-10,12-13,18-19,27H,6,11H2,2-4H3,(H,32,36)	OFVWHCAKFMVHBU-UHFFFAOYSA-N	794487	US20260062387, Example 18	Serine/threonine-protein kinase SIK1	Homo sapiens		 1.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794487&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			178423156	528825950							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125756	C#Cc1cc(-c2cnn(CC)c2)cc2nn(C)c(-c3cc(OC)c(C(=O)N[C@@H]4C[C@@H]4F)c(OC(F)F)c3)c12	InChI=1S/C27H24F3N5O3/c1-5-14-7-15(17-12-31-35(6-2)13-17)8-20-23(14)25(34(3)33-20)16-9-21(37-4)24(22(10-16)38-27(29)30)26(36)32-19-11-18(19)28/h1,7-10,12-13,18-19,27H,6,11H2,2-4H3,(H,32,36)	OFVWHCAKFMVHBU-UHFFFAOYSA-N	794487	US20260062387, Example 18	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794487&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			178423156	528825950							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125757	C#Cc1cc(-c2cnn(CC)c2)cc2nn(C)c(-c3cc(OC)c(C(=O)N[C@@H]4C[C@@H]4F)c(OC(F)F)c3)c12	InChI=1S/C27H24F3N5O3/c1-5-14-7-15(17-12-31-35(6-2)13-17)8-20-23(14)25(34(3)33-20)16-9-21(37-4)24(22(10-16)38-27(29)30)26(36)32-19-11-18(19)28/h1,7-10,12-13,18-19,27H,6,11H2,2-4H3,(H,32,36)	OFVWHCAKFMVHBU-UHFFFAOYSA-N	794487	US20260062387, Example 18	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794487&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			178423156	528825950							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125758	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCN(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H28F3N7O3/c1-36(2)5-6-38-14-18(13-33-38)15-7-17(12-32)24-21(8-15)35-37(3)26(24)16-9-22(40-4)25(23(10-16)41-28(30)31)27(39)34-20-11-19(20)29/h7-10,13-14,19-20,28H,5-6,11H2,1-4H3,(H,34,39)	HLGAQQYSANPKLN-UHFFFAOYSA-N	794488	US20260062387, Example 19	Serine/threonine-protein kinase SIK1	Homo sapiens		 2.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794488&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606231	528825951							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125759	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCN(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H28F3N7O3/c1-36(2)5-6-38-14-18(13-33-38)15-7-17(12-32)24-21(8-15)35-37(3)26(24)16-9-22(40-4)25(23(10-16)41-28(30)31)27(39)34-20-11-19(20)29/h7-10,13-14,19-20,28H,5-6,11H2,1-4H3,(H,34,39)	HLGAQQYSANPKLN-UHFFFAOYSA-N	794488	US20260062387, Example 19	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794488&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606231	528825951							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125760	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCN(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H28F3N7O3/c1-36(2)5-6-38-14-18(13-33-38)15-7-17(12-32)24-21(8-15)35-37(3)26(24)16-9-22(40-4)25(23(10-16)41-28(30)31)27(39)34-20-11-19(20)29/h7-10,13-14,19-20,28H,5-6,11H2,1-4H3,(H,34,39)	HLGAQQYSANPKLN-UHFFFAOYSA-N	794488	US20260062387, Example 19	Serine/threonine-protein kinase SIK3	Homo sapiens		 8.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794488&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606231	528825951							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125761	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H27F3N6O3/c1-28(2,3)37-13-17(12-33-37)14-6-16(11-32)23-20(7-14)35-36(4)25(23)15-8-21(39-5)24(22(9-15)40-27(30)31)26(38)34-19-10-18(19)29/h6-9,12-13,18-19,27H,10H2,1-5H3,(H,34,38)	WMWMMCTZNHBMSY-UHFFFAOYSA-N	794489	US20260062387, Example 20	Serine/threonine-protein kinase SIK1	Homo sapiens		 4.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794489&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606150	528825952							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125762	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H27F3N6O3/c1-28(2,3)37-13-17(12-33-37)14-6-16(11-32)23-20(7-14)35-36(4)25(23)15-8-21(39-5)24(22(9-15)40-27(30)31)26(38)34-19-10-18(19)29/h6-9,12-13,18-19,27H,10H2,1-5H3,(H,34,38)	WMWMMCTZNHBMSY-UHFFFAOYSA-N	794489	US20260062387, Example 20	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794489&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606150	528825952							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125763	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H27F3N6O3/c1-28(2,3)37-13-17(12-33-37)14-6-16(11-32)23-20(7-14)35-36(4)25(23)15-8-21(39-5)24(22(9-15)40-27(30)31)26(38)34-19-10-18(19)29/h6-9,12-13,18-19,27H,10H2,1-5H3,(H,34,38)	WMWMMCTZNHBMSY-UHFFFAOYSA-N	794489	US20260062387, Example 20	Serine/threonine-protein kinase SIK3	Homo sapiens		 13.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794489&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606150	528825952							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125764	COc1cc(-c2c3c(C#N)cc(-c4cc(C)ns4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H20F3N5O3S/c1-11-4-20(37-32-11)12-5-14(10-29)21-17(6-12)31-33(2)23(21)13-7-18(35-3)22(19(8-13)36-25(27)28)24(34)30-16-9-15(16)26/h4-8,15-16,25H,9H2,1-3H3,(H,30,34)	KAERTLUUNDVEDT-UHFFFAOYSA-N	794490	US20260062387, Example 21	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.9							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794490&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606140	528825953							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125765	COc1cc(-c2c3c(C#N)cc(-c4cc(C)ns4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H20F3N5O3S/c1-11-4-20(37-32-11)12-5-14(10-29)21-17(6-12)31-33(2)23(21)13-7-18(35-3)22(19(8-13)36-25(27)28)24(34)30-16-9-15(16)26/h4-8,15-16,25H,9H2,1-3H3,(H,30,34)	KAERTLUUNDVEDT-UHFFFAOYSA-N	794490	US20260062387, Example 21	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794490&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606140	528825953							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125766	COc1cc(-c2c3c(C#N)cc(-c4cc(C)ns4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C25H20F3N5O3S/c1-11-4-20(37-32-11)12-5-14(10-29)21-17(6-12)31-33(2)23(21)13-7-18(35-3)22(19(8-13)36-25(27)28)24(34)30-16-9-15(16)26/h4-8,15-16,25H,9H2,1-3H3,(H,30,34)	KAERTLUUNDVEDT-UHFFFAOYSA-N	794490	US20260062387, Example 21	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794490&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606140	528825953							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125767	COc1cc(-c2c3c(C#N)cc(-c4cnn(C5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H25F3N6O4/c1-36-26(15-7-22(39-2)25(23(8-15)41-28(30)31)27(38)34-20-9-19(20)29)24-16(10-32)5-14(6-21(24)35-36)17-11-33-37(12-17)18-3-4-40-13-18/h5-8,11-12,18-20,28H,3-4,9,13H2,1-2H3,(H,34,38)	OBFGVTOLYCYMSX-UHFFFAOYSA-N	794491	US20260062387, Example 22	Serine/threonine-protein kinase SIK1	Homo sapiens		 2.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794491&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606105	528825954							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125768	COc1cc(-c2c3c(C#N)cc(-c4cnn(C5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H25F3N6O4/c1-36-26(15-7-22(39-2)25(23(8-15)41-28(30)31)27(38)34-20-9-19(20)29)24-16(10-32)5-14(6-21(24)35-36)17-11-33-37(12-17)18-3-4-40-13-18/h5-8,11-12,18-20,28H,3-4,9,13H2,1-2H3,(H,34,38)	OBFGVTOLYCYMSX-UHFFFAOYSA-N	794491	US20260062387, Example 22	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794491&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606105	528825954							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125769	COc1cc(-c2c3c(C#N)cc(-c4cnn(C5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H25F3N6O4/c1-36-26(15-7-22(39-2)25(23(8-15)41-28(30)31)27(38)34-20-9-19(20)29)24-16(10-32)5-14(6-21(24)35-36)17-11-33-37(12-17)18-3-4-40-13-18/h5-8,11-12,18-20,28H,3-4,9,13H2,1-2H3,(H,34,38)	OBFGVTOLYCYMSX-UHFFFAOYSA-N	794491	US20260062387, Example 22	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794491&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606105	528825954							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125770	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C25H20F4N6O3/c1-34-11-15(10-31-34)12-4-14(9-30)20-16(5-12)33-35(2)22(20)13-6-17(37-3)21(18(7-13)38-24(26)27)23(36)32-19-8-25(19,28)29/h4-7,10-11,19,24H,8H2,1-3H3,(H,32,36)	KHBOKKCOEPFBMU-UHFFFAOYSA-N	794492	US20260062387, Example 23	Serine/threonine-protein kinase SIK1	Homo sapiens		 2.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794492&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606136	528825955							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125771	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C25H20F4N6O3/c1-34-11-15(10-31-34)12-4-14(9-30)20-16(5-12)33-35(2)22(20)13-6-17(37-3)21(18(7-13)38-24(26)27)23(36)32-19-8-25(19,28)29/h4-7,10-11,19,24H,8H2,1-3H3,(H,32,36)	KHBOKKCOEPFBMU-UHFFFAOYSA-N	794492	US20260062387, Example 23	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794492&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606136	528825955							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125772	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C25H20F4N6O3/c1-34-11-15(10-31-34)12-4-14(9-30)20-16(5-12)33-35(2)22(20)13-6-17(37-3)21(18(7-13)38-24(26)27)23(36)32-19-8-25(19,28)29/h4-7,10-11,19,24H,8H2,1-3H3,(H,32,36)	KHBOKKCOEPFBMU-UHFFFAOYSA-N	794492	US20260062387, Example 23	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794492&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606136	528825955							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125773	COc1cc(-c2c3c(C#N)cc(-c4cc[nH]n4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C24H19F3N6O3/c1-33-22(20-13(10-28)5-11(6-17(20)32-33)15-3-4-29-31-15)12-7-18(35-2)21(19(8-12)36-24(26)27)23(34)30-16-9-14(16)25/h3-8,14,16,24H,9H2,1-2H3,(H,29,31)(H,30,34)	JFEVKEGDHADHHC-UHFFFAOYSA-N	794493	US20260062387, Example 24	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794493&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605966	528825956							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125774	COc1cc(-c2c3c(C#N)cc(-c4cc[nH]n4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C24H19F3N6O3/c1-33-22(20-13(10-28)5-11(6-17(20)32-33)15-3-4-29-31-15)12-7-18(35-2)21(19(8-12)36-24(26)27)23(34)30-16-9-14(16)25/h3-8,14,16,24H,9H2,1-2H3,(H,29,31)(H,30,34)	JFEVKEGDHADHHC-UHFFFAOYSA-N	794493	US20260062387, Example 24	Serine/threonine-protein kinase SIK2	Homo sapiens		 6.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794493&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605966	528825956							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125775	COc1cc(-c2c3c(C#N)cc(-c4cc[nH]n4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C24H19F3N6O3/c1-33-22(20-13(10-28)5-11(6-17(20)32-33)15-3-4-29-31-15)12-7-18(35-2)21(19(8-12)36-24(26)27)23(34)30-16-9-14(16)25/h3-8,14,16,24H,9H2,1-2H3,(H,29,31)(H,30,34)	JFEVKEGDHADHHC-UHFFFAOYSA-N	794493	US20260062387, Example 24	Serine/threonine-protein kinase SIK3	Homo sapiens		 11.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794493&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605966	528825956							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125776	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C26H22F4N6O4/c1-34-10-16(9-32-34)13-4-15(8-31)20-17(5-13)33-35(2)22(20)14-6-18(39-3)21(19(7-14)40-25(29)30)23(37)36-11-26(38,12-36)24(27)28/h4-7,9-10,24-25,38H,11-12H2,1-3H3	OQWMRKGOWASECS-UHFFFAOYSA-N	794494	US20260062387, Example 25	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794494&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606082	528825957							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125777	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C26H22F4N6O4/c1-34-10-16(9-32-34)13-4-15(8-31)20-17(5-13)33-35(2)22(20)14-6-18(39-3)21(19(7-14)40-25(29)30)23(37)36-11-26(38,12-36)24(27)28/h4-7,9-10,24-25,38H,11-12H2,1-3H3	OQWMRKGOWASECS-UHFFFAOYSA-N	794494	US20260062387, Example 25	Serine/threonine-protein kinase SIK2	Homo sapiens		 10.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794494&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606082	528825957							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125778	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C26H22F4N6O4/c1-34-10-16(9-32-34)13-4-15(8-31)20-17(5-13)33-35(2)22(20)14-6-18(39-3)21(19(7-14)40-25(29)30)23(37)36-11-26(38,12-36)24(27)28/h4-7,9-10,24-25,38H,11-12H2,1-3H3	OQWMRKGOWASECS-UHFFFAOYSA-N	794494	US20260062387, Example 25	Serine/threonine-protein kinase SIK3	Homo sapiens		 12.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794494&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606082	528825957							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125779	COc1cc(-c2c3c(OCC4COC4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H28F5N5O6/c1-37-9-18(8-35-37)16-4-19-23(21(5-16)44-12-15-10-43-11-15)25(38(2)36-19)17-6-20(42-3)24(22(7-17)45-27(30)31)26(40)39-13-28(41,14-39)29(32,33)34/h4-9,15,27,41H,10-14H2,1-3H3	VJNHWXGMIOESMI-UHFFFAOYSA-N	794495	US20260062387, Example 26	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794495&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606177	528825958							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125780	COc1cc(-c2c3c(OCC4COC4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H28F5N5O6/c1-37-9-18(8-35-37)16-4-19-23(21(5-16)44-12-15-10-43-11-15)25(38(2)36-19)17-6-20(42-3)24(22(7-17)45-27(30)31)26(40)39-13-28(41,14-39)29(32,33)34/h4-9,15,27,41H,10-14H2,1-3H3	VJNHWXGMIOESMI-UHFFFAOYSA-N	794495	US20260062387, Example 26	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794495&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606177	528825958							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125781	COc1cc(-c2c3c(OCC4COC4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H28F5N5O6/c1-37-9-18(8-35-37)16-4-19-23(21(5-16)44-12-15-10-43-11-15)25(38(2)36-19)17-6-20(42-3)24(22(7-17)45-27(30)31)26(40)39-13-28(41,14-39)29(32,33)34/h4-9,15,27,41H,10-14H2,1-3H3	VJNHWXGMIOESMI-UHFFFAOYSA-N	794495	US20260062387, Example 26	Serine/threonine-protein kinase SIK3	Homo sapiens		 11.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794495&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606177	528825958							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125782	COc1cc(-c2c3c(OCC4CCC4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H30F5N5O5/c1-38-12-19(11-36-38)17-7-20-24(22(8-17)44-13-16-5-4-6-16)26(39(2)37-20)18-9-21(43-3)25(23(10-18)45-28(31)32)27(41)40-14-29(42,15-40)30(33,34)35/h7-12,16,28,42H,4-6,13-15H2,1-3H3	YKQQAIHZZFBFPF-UHFFFAOYSA-N	794496	US20260062387, Example 27	Serine/threonine-protein kinase SIK1	Homo sapiens		 13.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794496&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606060	528825959							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125783	COc1cc(-c2c3c(OCC4CCC4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H30F5N5O5/c1-38-12-19(11-36-38)17-7-20-24(22(8-17)44-13-16-5-4-6-16)26(39(2)37-20)18-9-21(43-3)25(23(10-18)45-28(31)32)27(41)40-14-29(42,15-40)30(33,34)35/h7-12,16,28,42H,4-6,13-15H2,1-3H3	YKQQAIHZZFBFPF-UHFFFAOYSA-N	794496	US20260062387, Example 27	Serine/threonine-protein kinase SIK2	Homo sapiens		 12.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794496&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606060	528825959							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125784	COc1cc(-c2c3c(OCC4CCC4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H30F5N5O5/c1-38-12-19(11-36-38)17-7-20-24(22(8-17)44-13-16-5-4-6-16)26(39(2)37-20)18-9-21(43-3)25(23(10-18)45-28(31)32)27(41)40-14-29(42,15-40)30(33,34)35/h7-12,16,28,42H,4-6,13-15H2,1-3H3	YKQQAIHZZFBFPF-UHFFFAOYSA-N	794496	US20260062387, Example 27	Serine/threonine-protein kinase SIK3	Homo sapiens		 16.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794496&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606060	528825959							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125785	COc1cc(-c2c3c(OCCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H28F5N5O6/c1-36-12-17(11-34-36)15-7-18-22(20(8-15)43-6-4-5-39)24(37(2)35-18)16-9-19(42-3)23(21(10-16)44-26(29)30)25(40)38-13-27(41,14-38)28(31,32)33/h7-12,26,39,41H,4-6,13-14H2,1-3H3	IPHLXIQRNVWEMH-UHFFFAOYSA-N	794497	US20260062387, Example 28	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794497&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606205	528825960							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125786	COc1cc(-c2c3c(OCCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H28F5N5O6/c1-36-12-17(11-34-36)15-7-18-22(20(8-15)43-6-4-5-39)24(37(2)35-18)16-9-19(42-3)23(21(10-16)44-26(29)30)25(40)38-13-27(41,14-38)28(31,32)33/h7-12,26,39,41H,4-6,13-14H2,1-3H3	IPHLXIQRNVWEMH-UHFFFAOYSA-N	794497	US20260062387, Example 28	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794497&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606205	528825960							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125787	COc1cc(-c2c3c(OCCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H28F5N5O6/c1-36-12-17(11-34-36)15-7-18-22(20(8-15)43-6-4-5-39)24(37(2)35-18)16-9-19(42-3)23(21(10-16)44-26(29)30)25(40)38-13-27(41,14-38)28(31,32)33/h7-12,26,39,41H,4-6,13-14H2,1-3H3	IPHLXIQRNVWEMH-UHFFFAOYSA-N	794497	US20260062387, Example 28	Serine/threonine-protein kinase SIK3	Homo sapiens		 13.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794497&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606205	528825960							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125788	COc1cc(-c2c3c(OCC4CC4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H28F5N5O5/c1-37-11-18(10-35-37)16-6-19-23(21(7-16)43-12-15-4-5-15)25(38(2)36-19)17-8-20(42-3)24(22(9-17)44-27(30)31)26(40)39-13-28(41,14-39)29(32,33)34/h6-11,15,27,41H,4-5,12-14H2,1-3H3	PENDTHCRJFXQST-UHFFFAOYSA-N	794498	US20260062387, Example 29	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794498&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606030	528825961							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125789	COc1cc(-c2c3c(OCC4CC4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H28F5N5O5/c1-37-11-18(10-35-37)16-6-19-23(21(7-16)43-12-15-4-5-15)25(38(2)36-19)17-8-20(42-3)24(22(9-17)44-27(30)31)26(40)39-13-28(41,14-39)29(32,33)34/h6-11,15,27,41H,4-5,12-14H2,1-3H3	PENDTHCRJFXQST-UHFFFAOYSA-N	794498	US20260062387, Example 29	Serine/threonine-protein kinase SIK2	Homo sapiens		 10.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794498&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606030	528825961							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125790	COc1cc(-c2c3c(OCC4CC4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H28F5N5O5/c1-37-11-18(10-35-37)16-6-19-23(21(7-16)43-12-15-4-5-15)25(38(2)36-19)17-8-20(42-3)24(22(9-17)44-27(30)31)26(40)39-13-28(41,14-39)29(32,33)34/h6-11,15,27,41H,4-5,12-14H2,1-3H3	PENDTHCRJFXQST-UHFFFAOYSA-N	794498	US20260062387, Example 29	Serine/threonine-protein kinase SIK3	Homo sapiens		 13.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794498&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606030	528825961							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125791	COc1cc(-c2c3c(OCC(F)(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C27H23F8N5O5/c1-38-9-15(8-36-38)13-4-16-20(18(5-13)44-12-26(30,31)32)22(39(2)37-16)14-6-17(43-3)21(19(7-14)45-24(28)29)23(41)40-10-25(42,11-40)27(33,34)35/h4-9,24,42H,10-12H2,1-3H3	VBYLHITWXNLUMZ-UHFFFAOYSA-N	794499	US20260062387, Example 30	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794499&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606214	528825962							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125792	COc1cc(-c2c3c(OCC(F)(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C27H23F8N5O5/c1-38-9-15(8-36-38)13-4-16-20(18(5-13)44-12-26(30,31)32)22(39(2)37-16)14-6-17(43-3)21(19(7-14)45-24(28)29)23(41)40-10-25(42,11-40)27(33,34)35/h4-9,24,42H,10-12H2,1-3H3	VBYLHITWXNLUMZ-UHFFFAOYSA-N	794499	US20260062387, Example 30	Serine/threonine-protein kinase SIK2	Homo sapiens		 6.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794499&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606214	528825962							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125793	COc1cc(-c2c3c(OCC(F)(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C27H23F8N5O5/c1-38-9-15(8-36-38)13-4-16-20(18(5-13)44-12-26(30,31)32)22(39(2)37-16)14-6-17(43-3)21(19(7-14)45-24(28)29)23(41)40-10-25(42,11-40)27(33,34)35/h4-9,24,42H,10-12H2,1-3H3	VBYLHITWXNLUMZ-UHFFFAOYSA-N	794499	US20260062387, Example 30	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794499&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606214	528825962							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125794	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C26H21F5N6O3/c1-36-24(13-5-19(39-2)23(20(6-13)40-26(30)31)25(38)34-17-7-16(17)27)22-14(8-32)3-12(4-18(22)35-36)15-9-33-37(10-15)11-21(28)29/h3-6,9-10,16-17,21,26H,7,11H2,1-2H3,(H,34,38)	GNWCSABVUGGGOB-UHFFFAOYSA-N	794500	US20260062387, Example 31	Serine/threonine-protein kinase SIK1	Homo sapiens		 3.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794500&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606233	528825963							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125795	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C26H21F5N6O3/c1-36-24(13-5-19(39-2)23(20(6-13)40-26(30)31)25(38)34-17-7-16(17)27)22-14(8-32)3-12(4-18(22)35-36)15-9-33-37(10-15)11-21(28)29/h3-6,9-10,16-17,21,26H,7,11H2,1-2H3,(H,34,38)	GNWCSABVUGGGOB-UHFFFAOYSA-N	794500	US20260062387, Example 31	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794500&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606233	528825963							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125796	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C26H21F5N6O3/c1-36-24(13-5-19(39-2)23(20(6-13)40-26(30)31)25(38)34-17-7-16(17)27)22-14(8-32)3-12(4-18(22)35-36)15-9-33-37(10-15)11-21(28)29/h3-6,9-10,16-17,21,26H,7,11H2,1-2H3,(H,34,38)	GNWCSABVUGGGOB-UHFFFAOYSA-N	794500	US20260062387, Example 31	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794500&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606233	528825963							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125797	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H25F3N6O3/c1-36-26(16-7-22(39-2)25(23(8-16)40-28(30)31)27(38)34-20-9-19(20)29)24-17(10-32)5-15(6-21(24)35-36)18-11-33-37(13-18)12-14-3-4-14/h5-8,11,13-14,19-20,28H,3-4,9,12H2,1-2H3,(H,34,38)	NVHOOZGLESNCDM-UHFFFAOYSA-N	794501	US20260062387, Example 32	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794501&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605958	528825964							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125798	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H25F3N6O3/c1-36-26(16-7-22(39-2)25(23(8-16)40-28(30)31)27(38)34-20-9-19(20)29)24-17(10-32)5-15(6-21(24)35-36)18-11-33-37(13-18)12-14-3-4-14/h5-8,11,13-14,19-20,28H,3-4,9,12H2,1-2H3,(H,34,38)	NVHOOZGLESNCDM-UHFFFAOYSA-N	794501	US20260062387, Example 32	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794501&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605958	528825964							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125799	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C28H25F3N6O3/c1-36-26(16-7-22(39-2)25(23(8-16)40-28(30)31)27(38)34-20-9-19(20)29)24-17(10-32)5-15(6-21(24)35-36)18-11-33-37(13-18)12-14-3-4-14/h5-8,11,13-14,19-20,28H,3-4,9,12H2,1-2H3,(H,34,38)	NVHOOZGLESNCDM-UHFFFAOYSA-N	794501	US20260062387, Example 32	Serine/threonine-protein kinase SIK3	Homo sapiens		 8.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794501&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605958	528825964							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125800	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C27H25F3N6O3/c1-13(2)36-12-17(11-32-36)14-5-16(10-31)23-20(6-14)34-35(3)25(23)15-7-21(38-4)24(22(8-15)39-27(29)30)26(37)33-19-9-18(19)28/h5-8,11-13,18-19,27H,9H2,1-4H3,(H,33,37)	LZJHCEARVUZVNY-UHFFFAOYSA-N	794502	US20260062387, Example 33	Serine/threonine-protein kinase SIK1	Homo sapiens		 4.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794502&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605938	528825965							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125801	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C27H25F3N6O3/c1-13(2)36-12-17(11-32-36)14-5-16(10-31)23-20(6-14)34-35(3)25(23)15-7-21(38-4)24(22(8-15)39-27(29)30)26(37)33-19-9-18(19)28/h5-8,11-13,18-19,27H,9H2,1-4H3,(H,33,37)	LZJHCEARVUZVNY-UHFFFAOYSA-N	794502	US20260062387, Example 33	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794502&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605938	528825965							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125802	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C27H25F3N6O3/c1-13(2)36-12-17(11-32-36)14-5-16(10-31)23-20(6-14)34-35(3)25(23)15-7-21(38-4)24(22(8-15)39-27(29)30)26(37)33-19-9-18(19)28/h5-8,11-13,18-19,27H,9H2,1-4H3,(H,33,37)	LZJHCEARVUZVNY-UHFFFAOYSA-N	794502	US20260062387, Example 33	Serine/threonine-protein kinase SIK3	Homo sapiens		 8.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794502&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605938	528825965							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125803	COc1cc(-c2c3c(OCc4cccnc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C31H27F5N6O5/c1-40-13-20(12-38-40)18-7-21-25(23(8-18)46-14-17-5-4-6-37-11-17)27(41(2)39-21)19-9-22(45-3)26(24(10-19)47-29(32)33)28(43)42-15-30(44,16-42)31(34,35)36/h4-13,29,44H,14-16H2,1-3H3	IONZZLOWHBVNDF-UHFFFAOYSA-N	794503	US20260062387, Example 34	Serine/threonine-protein kinase SIK1	Homo sapiens		 0.400							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794503&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606172	528825966							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125804	COc1cc(-c2c3c(OCc4cccnc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C31H27F5N6O5/c1-40-13-20(12-38-40)18-7-21-25(23(8-18)46-14-17-5-4-6-37-11-17)27(41(2)39-21)19-9-22(45-3)26(24(10-19)47-29(32)33)28(43)42-15-30(44,16-42)31(34,35)36/h4-13,29,44H,14-16H2,1-3H3	IONZZLOWHBVNDF-UHFFFAOYSA-N	794503	US20260062387, Example 34	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.000							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794503&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606172	528825966							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125805	COc1cc(-c2c3c(OCc4cccnc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C31H27F5N6O5/c1-40-13-20(12-38-40)18-7-21-25(23(8-18)46-14-17-5-4-6-37-11-17)27(41(2)39-21)19-9-22(45-3)26(24(10-19)47-29(32)33)28(43)42-15-30(44,16-42)31(34,35)36/h4-13,29,44H,14-16H2,1-3H3	IONZZLOWHBVNDF-UHFFFAOYSA-N	794503	US20260062387, Example 34	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794503&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606172	528825966							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125806	COc1cc(-c2c3c(OCc4ccncc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C31H27F5N6O5/c1-40-13-20(12-38-40)18-8-21-25(23(9-18)46-14-17-4-6-37-7-5-17)27(41(2)39-21)19-10-22(45-3)26(24(11-19)47-29(32)33)28(43)42-15-30(44,16-42)31(34,35)36/h4-13,29,44H,14-16H2,1-3H3	HKXVAINFHBTOFY-UHFFFAOYSA-N	794504	US20260062387, Example 35	Serine/threonine-protein kinase SIK1	Homo sapiens		 1.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794504&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606068	528825967							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125807	COc1cc(-c2c3c(OCc4ccncc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C31H27F5N6O5/c1-40-13-20(12-38-40)18-8-21-25(23(9-18)46-14-17-4-6-37-7-5-17)27(41(2)39-21)19-10-22(45-3)26(24(11-19)47-29(32)33)28(43)42-15-30(44,16-42)31(34,35)36/h4-13,29,44H,14-16H2,1-3H3	HKXVAINFHBTOFY-UHFFFAOYSA-N	794504	US20260062387, Example 35	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794504&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606068	528825967							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125808	COc1cc(-c2c3c(OCc4ccncc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C31H27F5N6O5/c1-40-13-20(12-38-40)18-8-21-25(23(9-18)46-14-17-4-6-37-7-5-17)27(41(2)39-21)19-10-22(45-3)26(24(11-19)47-29(32)33)28(43)42-15-30(44,16-42)31(34,35)36/h4-13,29,44H,14-16H2,1-3H3	HKXVAINFHBTOFY-UHFFFAOYSA-N	794504	US20260062387, Example 35	Serine/threonine-protein kinase SIK3	Homo sapiens		 12.9							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794504&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606068	528825967							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125809	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(N)(C(F)(F)F)C1	InChI=1S/C26H22F5N7O3/c1-36-10-16(9-34-36)13-4-15(8-32)20-17(5-13)35-37(2)22(20)14-6-18(40-3)21(19(7-14)41-24(27)28)23(39)38-11-25(33,12-38)26(29,30)31/h4-7,9-10,24H,11-12,33H2,1-3H3	DENHZECDIXGTKL-UHFFFAOYSA-N	794505	US20260062387, Example 36	Serine/threonine-protein kinase SIK1	Homo sapiens		 12.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794505&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606026	528825968							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125810	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(N)(C(F)(F)F)C1	InChI=1S/C26H22F5N7O3/c1-36-10-16(9-34-36)13-4-15(8-32)20-17(5-13)35-37(2)22(20)14-6-18(40-3)21(19(7-14)41-24(27)28)23(39)38-11-25(33,12-38)26(29,30)31/h4-7,9-10,24H,11-12,33H2,1-3H3	DENHZECDIXGTKL-UHFFFAOYSA-N	794505	US20260062387, Example 36	Serine/threonine-protein kinase SIK2	Homo sapiens		 15.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794505&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606026	528825968							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125811	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(N)(C(F)(F)F)C1	InChI=1S/C26H22F5N7O3/c1-36-10-16(9-34-36)13-4-15(8-32)20-17(5-13)35-37(2)22(20)14-6-18(40-3)21(19(7-14)41-24(27)28)23(39)38-11-25(33,12-38)26(29,30)31/h4-7,9-10,24H,11-12,33H2,1-3H3	DENHZECDIXGTKL-UHFFFAOYSA-N	794505	US20260062387, Example 36	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794505&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606026	528825968							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125812	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C26H25F4N5O5/c1-33-10-15(9-31-33)13-5-16-20(17(6-13)38-3)22(34(2)32-16)14-7-18(39-4)21(19(8-14)40-25(29)30)23(36)35-11-26(37,12-35)24(27)28/h5-10,24-25,37H,11-12H2,1-4H3	JDMQJIXSUSIGBV-UHFFFAOYSA-N	794506	US20260062387, Example 37	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794506&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606180	528825969							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125813	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C26H25F4N5O5/c1-33-10-15(9-31-33)13-5-16-20(17(6-13)38-3)22(34(2)32-16)14-7-18(39-4)21(19(8-14)40-25(29)30)23(36)35-11-26(37,12-35)24(27)28/h5-10,24-25,37H,11-12H2,1-4H3	JDMQJIXSUSIGBV-UHFFFAOYSA-N	794506	US20260062387, Example 37	Serine/threonine-protein kinase SIK2	Homo sapiens		 8.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794506&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606180	528825969							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125814	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C26H25F4N5O5/c1-33-10-15(9-31-33)13-5-16-20(17(6-13)38-3)22(34(2)32-16)14-7-18(39-4)21(19(8-14)40-25(29)30)23(36)35-11-26(37,12-35)24(27)28/h5-10,24-25,37H,11-12H2,1-4H3	JDMQJIXSUSIGBV-UHFFFAOYSA-N	794506	US20260062387, Example 37	Serine/threonine-protein kinase SIK3	Homo sapiens		 12.9							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794506&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606180	528825969							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125815	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C26H23F6N5O4/c1-35-9-14(8-33-35)12-4-15(22(27)28)19-16(5-12)34-36(2)21(19)13-6-17(40-3)20(18(7-13)41-25(31)32)23(38)37-10-26(39,11-37)24(29)30/h4-9,22,24-25,39H,10-11H2,1-3H3	NCICFZOUTNHUOR-UHFFFAOYSA-N	794507	US20260062387, Example 38	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794507&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605954	528825970							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125816	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C26H23F6N5O4/c1-35-9-14(8-33-35)12-4-15(22(27)28)19-16(5-12)34-36(2)21(19)13-6-17(40-3)20(18(7-13)41-25(31)32)23(38)37-10-26(39,11-37)24(29)30/h4-9,22,24-25,39H,10-11H2,1-3H3	NCICFZOUTNHUOR-UHFFFAOYSA-N	794507	US20260062387, Example 38	Serine/threonine-protein kinase SIK2	Homo sapiens		 13.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794507&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605954	528825970							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125817	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C26H23F6N5O4/c1-35-9-14(8-33-35)12-4-15(22(27)28)19-16(5-12)34-36(2)21(19)13-6-17(40-3)20(18(7-13)41-25(31)32)23(38)37-10-26(39,11-37)24(29)30/h4-9,22,24-25,39H,10-11H2,1-3H3	NCICFZOUTNHUOR-UHFFFAOYSA-N	794507	US20260062387, Example 38	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794507&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605954	528825970							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125818	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(C#N)(C(F)F)C1	InChI=1S/C27H21F4N7O3/c1-36-10-17(9-34-36)14-4-16(8-32)21-18(5-14)35-37(2)23(21)15-6-19(40-3)22(20(7-15)41-26(30)31)24(39)38-12-27(11-33,13-38)25(28)29/h4-7,9-10,25-26H,12-13H2,1-3H3	NLZIHLILDYEHQQ-UHFFFAOYSA-N	794508	US20260062387, Example 39	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794508&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606137	528825971							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125819	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(C#N)(C(F)F)C1	InChI=1S/C27H21F4N7O3/c1-36-10-17(9-34-36)14-4-16(8-32)21-18(5-14)35-37(2)23(21)15-6-19(40-3)22(20(7-15)41-26(30)31)24(39)38-12-27(11-33,13-38)25(28)29/h4-7,9-10,25-26H,12-13H2,1-3H3	NLZIHLILDYEHQQ-UHFFFAOYSA-N	794508	US20260062387, Example 39	Serine/threonine-protein kinase SIK2	Homo sapiens		 18.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794508&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606137	528825971							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125820	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(C#N)(C(F)F)C1	InChI=1S/C27H21F4N7O3/c1-36-10-17(9-34-36)14-4-16(8-32)21-18(5-14)35-37(2)23(21)15-6-19(40-3)22(20(7-15)41-26(30)31)24(39)38-12-27(11-33,13-38)25(28)29/h4-7,9-10,25-26H,12-13H2,1-3H3	NLZIHLILDYEHQQ-UHFFFAOYSA-N	794508	US20260062387, Example 39	Serine/threonine-protein kinase SIK3	Homo sapiens		 9.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794508&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606137	528825971							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125821	COc1cc(-c2c3c(C#N)cc(/C=C/c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C27H23F3N6O3/c1-35-13-15(12-32-35)5-4-14-6-17(11-31)23-20(7-14)34-36(2)25(23)16-8-21(38-3)24(22(9-16)39-27(29)30)26(37)33-19-10-18(19)28/h4-9,12-13,18-19,27H,10H2,1-3H3,(H,33,37)	PBNDCJBAYOJLGI-UHFFFAOYSA-N	794509	US20260062387, Example 40	Serine/threonine-protein kinase SIK1	Homo sapiens		 4.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794509&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605955	528825972							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125822	COc1cc(-c2c3c(C#N)cc(/C=C/c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C27H23F3N6O3/c1-35-13-15(12-32-35)5-4-14-6-17(11-31)23-20(7-14)34-36(2)25(23)16-8-21(38-3)24(22(9-16)39-27(29)30)26(37)33-19-10-18(19)28/h4-9,12-13,18-19,27H,10H2,1-3H3,(H,33,37)	PBNDCJBAYOJLGI-UHFFFAOYSA-N	794509	US20260062387, Example 40	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794509&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605955	528825972							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125823	COc1cc(-c2c3c(C#N)cc(/C=C/c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C27H23F3N6O3/c1-35-13-15(12-32-35)5-4-14-6-17(11-31)23-20(7-14)34-36(2)25(23)16-8-21(38-3)24(22(9-16)39-27(29)30)26(37)33-19-10-18(19)28/h4-9,12-13,18-19,27H,10H2,1-3H3,(H,33,37)	PBNDCJBAYOJLGI-UHFFFAOYSA-N	794509	US20260062387, Example 40	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794509&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605955	528825972							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125824	COc1cc(-c2c3c(OCC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C27H24F7N5O5/c1-37-9-15(8-35-37)13-4-16-21(18(5-13)43-10-20(28)29)23(38(2)36-16)14-6-17(42-3)22(19(7-14)44-25(30)31)24(40)39-11-26(41,12-39)27(32,33)34/h4-9,20,25,41H,10-12H2,1-3H3	DTLMSLBCOSGDFF-UHFFFAOYSA-N	794510	US20260062387, Example 41	Serine/threonine-protein kinase SIK1	Homo sapiens		 1.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794510&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605940	528825973							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125825	COc1cc(-c2c3c(OCC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C27H24F7N5O5/c1-37-9-15(8-35-37)13-4-16-21(18(5-13)43-10-20(28)29)23(38(2)36-16)14-6-17(42-3)22(19(7-14)44-25(30)31)24(40)39-11-26(41,12-39)27(32,33)34/h4-9,20,25,41H,10-12H2,1-3H3	DTLMSLBCOSGDFF-UHFFFAOYSA-N	794510	US20260062387, Example 41	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794510&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605940	528825973							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125826	COc1cc(-c2c3c(OCC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C27H24F7N5O5/c1-37-9-15(8-35-37)13-4-16-21(18(5-13)43-10-20(28)29)23(38(2)36-16)14-6-17(42-3)22(19(7-14)44-25(30)31)24(40)39-11-26(41,12-39)27(32,33)34/h4-9,20,25,41H,10-12H2,1-3H3	DTLMSLBCOSGDFF-UHFFFAOYSA-N	794510	US20260062387, Example 41	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794510&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605940	528825973							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125827	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H24F5N5O5/c1-34-10-15(9-32-34)13-5-16-20(17(6-13)39-3)22(35(2)33-16)14-7-18(40-4)21(19(8-14)41-24(27)28)23(37)36-11-25(38,12-36)26(29,30)31/h5-10,24,38H,11-12H2,1-4H3	FVHDANMZHPAIIM-UHFFFAOYSA-N	794511	US20260062387, Example 42	Serine/threonine-protein kinase SIK1	Homo sapiens		 2.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794511&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606055	528825974							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125828	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H24F5N5O5/c1-34-10-15(9-32-34)13-5-16-20(17(6-13)39-3)22(35(2)33-16)14-7-18(40-4)21(19(8-14)41-24(27)28)23(37)36-11-25(38,12-36)26(29,30)31/h5-10,24,38H,11-12H2,1-4H3	FVHDANMZHPAIIM-UHFFFAOYSA-N	794511	US20260062387, Example 42	Serine/threonine-protein kinase SIK2	Homo sapiens		 12.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794511&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606055	528825974							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125829	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H24F5N5O5/c1-34-10-15(9-32-34)13-5-16-20(17(6-13)39-3)22(35(2)33-16)14-7-18(40-4)21(19(8-14)41-24(27)28)23(37)36-11-25(38,12-36)26(29,30)31/h5-10,24,38H,11-12H2,1-4H3	FVHDANMZHPAIIM-UHFFFAOYSA-N	794511	US20260062387, Example 42	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794511&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606055	528825974							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125830	COc1cc(-c2c3c(OC(C)C)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H28F5N5O5/c1-14(2)42-20-7-15(17-10-34-36(3)11-17)6-18-22(20)24(37(4)35-18)16-8-19(41-5)23(21(9-16)43-26(29)30)25(39)38-12-27(40,13-38)28(31,32)33/h6-11,14,26,40H,12-13H2,1-5H3	PHULHGBQODVMNG-UHFFFAOYSA-N	794512	US20260062387, Example 43	Serine/threonine-protein kinase SIK1	Homo sapiens		 2.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794512&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606224	528825975							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125831	COc1cc(-c2c3c(OC(C)C)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H28F5N5O5/c1-14(2)42-20-7-15(17-10-34-36(3)11-17)6-18-22(20)24(37(4)35-18)16-8-19(41-5)23(21(9-16)43-26(29)30)25(39)38-12-27(40,13-38)28(31,32)33/h6-11,14,26,40H,12-13H2,1-5H3	PHULHGBQODVMNG-UHFFFAOYSA-N	794512	US20260062387, Example 43	Serine/threonine-protein kinase SIK2	Homo sapiens		 19.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794512&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606224	528825975							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125832	COc1cc(-c2c3c(OC(C)C)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H28F5N5O5/c1-14(2)42-20-7-15(17-10-34-36(3)11-17)6-18-22(20)24(37(4)35-18)16-8-19(41-5)23(21(9-16)43-26(29)30)25(39)38-12-27(40,13-38)28(31,32)33/h6-11,14,26,40H,12-13H2,1-5H3	PHULHGBQODVMNG-UHFFFAOYSA-N	794512	US20260062387, Example 43	Serine/threonine-protein kinase SIK3	Homo sapiens		 20.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794512&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606224	528825975							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125833	COc1cc(-c2c3c(OCCCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H30F5N5O6/c1-37-13-18(12-35-37)16-8-19-23(21(9-16)44-7-5-4-6-40)25(38(2)36-19)17-10-20(43-3)24(22(11-17)45-27(30)31)26(41)39-14-28(42,15-39)29(32,33)34/h8-13,27,40,42H,4-7,14-15H2,1-3H3	BITDSGQNPGBWLW-UHFFFAOYSA-N	794513	US20260062387, Example 44	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794513&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606071	528825976							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125834	COc1cc(-c2c3c(OCCCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H30F5N5O6/c1-37-13-18(12-35-37)16-8-19-23(21(9-16)44-7-5-4-6-40)25(38(2)36-19)17-10-20(43-3)24(22(11-17)45-27(30)31)26(41)39-14-28(42,15-39)29(32,33)34/h8-13,27,40,42H,4-7,14-15H2,1-3H3	BITDSGQNPGBWLW-UHFFFAOYSA-N	794513	US20260062387, Example 44	Serine/threonine-protein kinase SIK2	Homo sapiens		 8.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794513&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606071	528825976							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125835	COc1cc(-c2c3c(OCCCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H30F5N5O6/c1-37-13-18(12-35-37)16-8-19-23(21(9-16)44-7-5-4-6-40)25(38(2)36-19)17-10-20(43-3)24(22(11-17)45-27(30)31)26(41)39-14-28(42,15-39)29(32,33)34/h8-13,27,40,42H,4-7,14-15H2,1-3H3	BITDSGQNPGBWLW-UHFFFAOYSA-N	794513	US20260062387, Example 44	Serine/threonine-protein kinase SIK3	Homo sapiens		 15.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794513&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606071	528825976							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125836	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C25H23F4N5O4/c1-33-11-14(10-30-33)12-5-15-20(16(6-12)36-3)22(34(2)32-15)13-7-17(37-4)21(18(8-13)38-24(26)27)23(35)31-19-9-25(19,28)29/h5-8,10-11,19,24H,9H2,1-4H3,(H,31,35)	HXDJTERBWLICBH-UHFFFAOYSA-N	794514	N-[(1R)-2,2-difluorocyclopropyl]-2-(difluoromethoxy)-6-methoxy-4-[4-methoxy-2-methyl-6-(1-methylpyrazol-4-yl)indazol-3-yl]benzamide::US20260062387, Example 45	Serine/threonine-protein kinase SIK1	Homo sapiens		 18.9							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794514&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606024	528825977							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125837	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C25H23F4N5O4/c1-33-11-14(10-30-33)12-5-15-20(16(6-12)36-3)22(34(2)32-15)13-7-17(37-4)21(18(8-13)38-24(26)27)23(35)31-19-9-25(19,28)29/h5-8,10-11,19,24H,9H2,1-4H3,(H,31,35)	HXDJTERBWLICBH-UHFFFAOYSA-N	794514	N-[(1R)-2,2-difluorocyclopropyl]-2-(difluoromethoxy)-6-methoxy-4-[4-methoxy-2-methyl-6-(1-methylpyrazol-4-yl)indazol-3-yl]benzamide::US20260062387, Example 45	Serine/threonine-protein kinase SIK2	Homo sapiens		 8.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794514&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606024	528825977							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125838	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C25H23F4N5O4/c1-33-11-14(10-30-33)12-5-15-20(16(6-12)36-3)22(34(2)32-15)13-7-17(37-4)21(18(8-13)38-24(26)27)23(35)31-19-9-25(19,28)29/h5-8,10-11,19,24H,9H2,1-4H3,(H,31,35)	HXDJTERBWLICBH-UHFFFAOYSA-N	794514	N-[(1R)-2,2-difluorocyclopropyl]-2-(difluoromethoxy)-6-methoxy-4-[4-methoxy-2-methyl-6-(1-methylpyrazol-4-yl)indazol-3-yl]benzamide::US20260062387, Example 45	Serine/threonine-protein kinase SIK3	Homo sapiens		 9.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794514&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606024	528825977							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125839	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@H]1CC1(F)F	InChI=1S/C25H23F4N5O4/c1-33-11-14(10-30-33)12-5-15-20(16(6-12)36-3)22(34(2)32-15)13-7-17(37-4)21(18(8-13)38-24(26)27)23(35)31-19-9-25(19,28)29/h5-8,10-11,19,24H,9H2,1-4H3,(H,31,35)	HXDJTERBWLICBH-UHFFFAOYSA-N	794515	US20260062387, Example 46	Serine/threonine-protein kinase SIK1	Homo sapiens		 14.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794515&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			178423157	528825978							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125840	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@H]1CC1(F)F	InChI=1S/C25H23F4N5O4/c1-33-11-14(10-30-33)12-5-15-20(16(6-12)36-3)22(34(2)32-15)13-7-17(37-4)21(18(8-13)38-24(26)27)23(35)31-19-9-25(19,28)29/h5-8,10-11,19,24H,9H2,1-4H3,(H,31,35)	HXDJTERBWLICBH-UHFFFAOYSA-N	794515	US20260062387, Example 46	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794515&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			178423157	528825978							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125841	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@H]1CC1(F)F	InChI=1S/C25H23F4N5O4/c1-33-11-14(10-30-33)12-5-15-20(16(6-12)36-3)22(34(2)32-15)13-7-17(37-4)21(18(8-13)38-24(26)27)23(35)31-19-9-25(19,28)29/h5-8,10-11,19,24H,9H2,1-4H3,(H,31,35)	HXDJTERBWLICBH-UHFFFAOYSA-N	794515	US20260062387, Example 46	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794515&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			178423157	528825978							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125842	COc1cc(-c2c3c(OCC[C@H](C)O)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H30F5N5O6/c1-15(40)5-6-44-21-8-16(18-11-35-37(2)12-18)7-19-23(21)25(38(3)36-19)17-9-20(43-4)24(22(10-17)45-27(30)31)26(41)39-13-28(42,14-39)29(32,33)34/h7-12,15,27,40,42H,5-6,13-14H2,1-4H3	KVPVMSGUTTZWCD-UHFFFAOYSA-N	794516	US20260062387, Example 47	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794516&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605985	528825979							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125843	COc1cc(-c2c3c(OCC[C@H](C)O)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H30F5N5O6/c1-15(40)5-6-44-21-8-16(18-11-35-37(2)12-18)7-19-23(21)25(38(3)36-19)17-9-20(43-4)24(22(10-17)45-27(30)31)26(41)39-13-28(42,14-39)29(32,33)34/h7-12,15,27,40,42H,5-6,13-14H2,1-4H3	KVPVMSGUTTZWCD-UHFFFAOYSA-N	794516	US20260062387, Example 47	Serine/threonine-protein kinase SIK2	Homo sapiens		 16.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794516&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605985	528825979							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125844	COc1cc(-c2c3c(OCC[C@H](C)O)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H30F5N5O6/c1-15(40)5-6-44-21-8-16(18-11-35-37(2)12-18)7-19-23(21)25(38(3)36-19)17-9-20(43-4)24(22(10-17)45-27(30)31)26(41)39-13-28(42,14-39)29(32,33)34/h7-12,15,27,40,42H,5-6,13-14H2,1-4H3	KVPVMSGUTTZWCD-UHFFFAOYSA-N	794516	US20260062387, Example 47	Serine/threonine-protein kinase SIK3	Homo sapiens		 19.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794516&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605985	528825979							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125845	COc1cc(-c2c3c(OCc4cnccn4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H26F5N7O5/c1-40-12-18(10-38-40)16-6-20-24(22(7-16)46-13-19-11-36-4-5-37-19)26(41(2)39-20)17-8-21(45-3)25(23(9-17)47-28(31)32)27(43)42-14-29(44,15-42)30(33,34)35/h4-12,28,44H,13-15H2,1-3H3	JUWDYUFBRXFFIF-UHFFFAOYSA-N	794517	US20260062387, Example 48	Serine/threonine-protein kinase SIK1	Homo sapiens		 3.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794517&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606080	528825980							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125846	COc1cc(-c2c3c(OCc4cnccn4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H26F5N7O5/c1-40-12-18(10-38-40)16-6-20-24(22(7-16)46-13-19-11-36-4-5-37-19)26(41(2)39-20)17-8-21(45-3)25(23(9-17)47-28(31)32)27(43)42-14-29(44,15-42)30(33,34)35/h4-12,28,44H,13-15H2,1-3H3	JUWDYUFBRXFFIF-UHFFFAOYSA-N	794517	US20260062387, Example 48	Serine/threonine-protein kinase SIK2	Homo sapiens		 10.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794517&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606080	528825980							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125847	COc1cc(-c2c3c(OCc4cnccn4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H26F5N7O5/c1-40-12-18(10-38-40)16-6-20-24(22(7-16)46-13-19-11-36-4-5-37-19)26(41(2)39-20)17-8-21(45-3)25(23(9-17)47-28(31)32)27(43)42-14-29(44,15-42)30(33,34)35/h4-12,28,44H,13-15H2,1-3H3	JUWDYUFBRXFFIF-UHFFFAOYSA-N	794517	US20260062387, Example 48	Serine/threonine-protein kinase SIK3	Homo sapiens		 11.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794517&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606080	528825980							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125848	COc1cc(-c2c3c(OCc4cnc(C)s4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H27F5N6O5S/c1-15-36-10-19(47-15)12-45-22-6-16(18-9-37-39(2)11-18)5-20-24(22)26(40(3)38-20)17-7-21(44-4)25(23(8-17)46-28(31)32)27(42)41-13-29(43,14-41)30(33,34)35/h5-11,28,43H,12-14H2,1-4H3	AODTYFORASIGSY-UHFFFAOYSA-N	794518	US20260062387, Example 49	Serine/threonine-protein kinase SIK1	Homo sapiens		 3.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794518&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606038	528825981							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125849	COc1cc(-c2c3c(OCc4cnc(C)s4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H27F5N6O5S/c1-15-36-10-19(47-15)12-45-22-6-16(18-9-37-39(2)11-18)5-20-24(22)26(40(3)38-20)17-7-21(44-4)25(23(8-17)46-28(31)32)27(42)41-13-29(43,14-41)30(33,34)35/h5-11,28,43H,12-14H2,1-4H3	AODTYFORASIGSY-UHFFFAOYSA-N	794518	US20260062387, Example 49	Serine/threonine-protein kinase SIK2	Homo sapiens		 11.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794518&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606038	528825981							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125850	COc1cc(-c2c3c(OCc4cnc(C)s4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H27F5N6O5S/c1-15-36-10-19(47-15)12-45-22-6-16(18-9-37-39(2)11-18)5-20-24(22)26(40(3)38-20)17-7-21(44-4)25(23(8-17)46-28(31)32)27(42)41-13-29(43,14-41)30(33,34)35/h5-11,28,43H,12-14H2,1-4H3	AODTYFORASIGSY-UHFFFAOYSA-N	794518	US20260062387, Example 49	Serine/threonine-protein kinase SIK3	Homo sapiens		 9.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794518&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606038	528825981							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125851	COc1cc(-c2c3c(OCc4ccc(C)nc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C32H29F5N6O5/c1-17-5-6-18(11-38-17)14-47-24-8-19(21-12-39-41(2)13-21)7-22-26(24)28(42(3)40-22)20-9-23(46-4)27(25(10-20)48-30(33)34)29(44)43-15-31(45,16-43)32(35,36)37/h5-13,30,45H,14-16H2,1-4H3	KGKGTBKXQLDSRK-UHFFFAOYSA-N	794519	US20260062387, Example 50	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794519&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606056	528825982							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125852	COc1cc(-c2c3c(OCc4ccc(C)nc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C32H29F5N6O5/c1-17-5-6-18(11-38-17)14-47-24-8-19(21-12-39-41(2)13-21)7-22-26(24)28(42(3)40-22)20-9-23(46-4)27(25(10-20)48-30(33)34)29(44)43-15-31(45,16-43)32(35,36)37/h5-13,30,45H,14-16H2,1-4H3	KGKGTBKXQLDSRK-UHFFFAOYSA-N	794519	US20260062387, Example 50	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794519&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606056	528825982							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125853	COc1cc(-c2c3c(OCc4ccc(C)nc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C32H29F5N6O5/c1-17-5-6-18(11-38-17)14-47-24-8-19(21-12-39-41(2)13-21)7-22-26(24)28(42(3)40-22)20-9-23(46-4)27(25(10-20)48-30(33)34)29(44)43-15-31(45,16-43)32(35,36)37/h5-13,30,45H,14-16H2,1-4H3	KGKGTBKXQLDSRK-UHFFFAOYSA-N	794519	US20260062387, Example 50	Serine/threonine-protein kinase SIK3	Homo sapiens		 17.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794519&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606056	528825982							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125854	COc1cc(-c2c3c(OCc4ccnnc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H26F5N7O5/c1-40-12-19(11-38-40)17-6-20-24(22(7-17)46-13-16-4-5-36-37-10-16)26(41(2)39-20)18-8-21(45-3)25(23(9-18)47-28(31)32)27(43)42-14-29(44,15-42)30(33,34)35/h4-12,28,44H,13-15H2,1-3H3	PXRCMAYYVPMIJJ-UHFFFAOYSA-N	794520	US20260062387, Example 51	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794520&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606122	528825983							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125855	COc1cc(-c2c3c(OCc4ccnnc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H26F5N7O5/c1-40-12-19(11-38-40)17-6-20-24(22(7-17)46-13-16-4-5-36-37-10-16)26(41(2)39-20)18-8-21(45-3)25(23(9-18)47-28(31)32)27(43)42-14-29(44,15-42)30(33,34)35/h4-12,28,44H,13-15H2,1-3H3	PXRCMAYYVPMIJJ-UHFFFAOYSA-N	794520	US20260062387, Example 51	Serine/threonine-protein kinase SIK2	Homo sapiens		 8.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794520&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606122	528825983							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125856	COc1cc(-c2c3c(OCc4ccnnc4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H26F5N7O5/c1-40-12-19(11-38-40)17-6-20-24(22(7-17)46-13-16-4-5-36-37-10-16)26(41(2)39-20)18-8-21(45-3)25(23(9-18)47-28(31)32)27(43)42-14-29(44,15-42)30(33,34)35/h4-12,28,44H,13-15H2,1-3H3	PXRCMAYYVPMIJJ-UHFFFAOYSA-N	794520	US20260062387, Example 51	Serine/threonine-protein kinase SIK3	Homo sapiens		 14.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794520&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606122	528825983							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125857	COc1cc(-c2c3c(OCc4cnn(C)c4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H28F5N7O5/c1-39-11-16(9-36-39)13-46-22-6-17(19-10-37-40(2)12-19)5-20-24(22)26(41(3)38-20)18-7-21(45-4)25(23(8-18)47-28(31)32)27(43)42-14-29(44,15-42)30(33,34)35/h5-12,28,44H,13-15H2,1-4H3	CNMRCBNBEBKEBQ-UHFFFAOYSA-N	794521	US20260062387, Example 52	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794521&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606209	528825984							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125858	COc1cc(-c2c3c(OCc4cnn(C)c4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H28F5N7O5/c1-39-11-16(9-36-39)13-46-22-6-17(19-10-37-40(2)12-19)5-20-24(22)26(41(3)38-20)18-7-21(45-4)25(23(8-18)47-28(31)32)27(43)42-14-29(44,15-42)30(33,34)35/h5-12,28,44H,13-15H2,1-4H3	CNMRCBNBEBKEBQ-UHFFFAOYSA-N	794521	US20260062387, Example 52	Serine/threonine-protein kinase SIK2	Homo sapiens		 6.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794521&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606209	528825984							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125859	COc1cc(-c2c3c(OCc4cnn(C)c4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H28F5N7O5/c1-39-11-16(9-36-39)13-46-22-6-17(19-10-37-40(2)12-19)5-20-24(22)26(41(3)38-20)18-7-21(45-4)25(23(8-18)47-28(31)32)27(43)42-14-29(44,15-42)30(33,34)35/h5-12,28,44H,13-15H2,1-4H3	CNMRCBNBEBKEBQ-UHFFFAOYSA-N	794521	US20260062387, Example 52	Serine/threonine-protein kinase SIK3	Homo sapiens		 9.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794521&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606209	528825984							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125860	COc1cc(-c2c3c(OCc4nnc(C)o4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H26F5N7O6/c1-14-36-37-22(46-14)11-45-20-6-15(17-9-35-39(2)10-17)5-18-23(20)25(40(3)38-18)16-7-19(44-4)24(21(8-16)47-27(30)31)26(42)41-12-28(43,13-41)29(32,33)34/h5-10,27,43H,11-13H2,1-4H3	OVZPZYQVSHUKRD-UHFFFAOYSA-N	794522	US20260062387, Example 53	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794522&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606062	528825985							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125861	COc1cc(-c2c3c(OCc4nnc(C)o4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H26F5N7O6/c1-14-36-37-22(46-14)11-45-20-6-15(17-9-35-39(2)10-17)5-18-23(20)25(40(3)38-18)16-7-19(44-4)24(21(8-16)47-27(30)31)26(42)41-12-28(43,13-41)29(32,33)34/h5-10,27,43H,11-13H2,1-4H3	OVZPZYQVSHUKRD-UHFFFAOYSA-N	794522	US20260062387, Example 53	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794522&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606062	528825985							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125862	COc1cc(-c2c3c(OCc4nnc(C)o4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H26F5N7O6/c1-14-36-37-22(46-14)11-45-20-6-15(17-9-35-39(2)10-17)5-18-23(20)25(40(3)38-18)16-7-19(44-4)24(21(8-16)47-27(30)31)26(42)41-12-28(43,13-41)29(32,33)34/h5-10,27,43H,11-13H2,1-4H3	OVZPZYQVSHUKRD-UHFFFAOYSA-N	794522	US20260062387, Example 53	Serine/threonine-protein kinase SIK3	Homo sapiens		 13.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794522&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606062	528825985							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125863	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCS(C)(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C28H27F3N6O5S/c1-36-25(17-10-21(41-2)24(22(11-17)42-27(29)30)26(38)33-15-28(31)4-5-28)23-18(12-32)8-16(9-20(23)35-36)19-13-34-37(14-19)6-7-43(3,39)40/h8-11,13-14,27H,4-7,15H2,1-3H3,(H,33,38)	WTDTZFAZCOOKQM-UHFFFAOYSA-N	794523	US20260062387, Example 54	Serine/threonine-protein kinase SIK1	Homo sapiens		 10.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794523&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606079	528825986							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125864	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCS(C)(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C28H27F3N6O5S/c1-36-25(17-10-21(41-2)24(22(11-17)42-27(29)30)26(38)33-15-28(31)4-5-28)23-18(12-32)8-16(9-20(23)35-36)19-13-34-37(14-19)6-7-43(3,39)40/h8-11,13-14,27H,4-7,15H2,1-3H3,(H,33,38)	WTDTZFAZCOOKQM-UHFFFAOYSA-N	794523	US20260062387, Example 54	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794523&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606079	528825986							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125865	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCS(C)(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C28H27F3N6O5S/c1-36-25(17-10-21(41-2)24(22(11-17)42-27(29)30)26(38)33-15-28(31)4-5-28)23-18(12-32)8-16(9-20(23)35-36)19-13-34-37(14-19)6-7-43(3,39)40/h8-11,13-14,27H,4-7,15H2,1-3H3,(H,33,38)	WTDTZFAZCOOKQM-UHFFFAOYSA-N	794523	US20260062387, Example 54	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794523&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606079	528825986							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125866	Cn1cc(-c2cc(C#N)c3c(-c4ccc(C(=O)N[C@@H]5CC5(F)F)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H18F4N6O2/c1-33-11-15(10-30-33)13-5-14(9-29)20-17(6-13)32-34(2)21(20)12-3-4-16(18(7-12)36-23(25)26)22(35)31-19-8-24(19,27)28/h3-7,10-11,19,23H,8H2,1-2H3,(H,31,35)	WIUMTNYTHUTUNH-UHFFFAOYSA-N	794524	US20260062387, Example 55	Serine/threonine-protein kinase SIK1	Homo sapiens		 10.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794524&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605949	528825987							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125867	Cn1cc(-c2cc(C#N)c3c(-c4ccc(C(=O)N[C@@H]5CC5(F)F)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H18F4N6O2/c1-33-11-15(10-30-33)13-5-14(9-29)20-17(6-13)32-34(2)21(20)12-3-4-16(18(7-12)36-23(25)26)22(35)31-19-8-24(19,27)28/h3-7,10-11,19,23H,8H2,1-2H3,(H,31,35)	WIUMTNYTHUTUNH-UHFFFAOYSA-N	794524	US20260062387, Example 55	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794524&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605949	528825987							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125868	Cn1cc(-c2cc(C#N)c3c(-c4ccc(C(=O)N[C@@H]5CC5(F)F)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H18F4N6O2/c1-33-11-15(10-30-33)13-5-14(9-29)20-17(6-13)32-34(2)21(20)12-3-4-16(18(7-12)36-23(25)26)22(35)31-19-8-24(19,27)28/h3-7,10-11,19,23H,8H2,1-2H3,(H,31,35)	WIUMTNYTHUTUNH-UHFFFAOYSA-N	794524	US20260062387, Example 55	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794524&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605949	528825987							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125869	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H29F3N6O4/c1-28(2,40)15-38-13-19(12-35-38)16-7-18(11-33)23-20(8-16)36-37(3)25(23)17-9-21(41-4)24(22(10-17)42-27(30)31)26(39)34-14-29(32)5-6-29/h7-10,12-13,27,40H,5-6,14-15H2,1-4H3,(H,34,39)	GZFXZQJKSZVCDY-UHFFFAOYSA-N	794525	US20260062387, Example 56	Serine/threonine-protein kinase SIK1	Homo sapiens		 20.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794525&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606040	528825988							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125870	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H29F3N6O4/c1-28(2,40)15-38-13-19(12-35-38)16-7-18(11-33)23-20(8-16)36-37(3)25(23)17-9-21(41-4)24(22(10-17)42-27(30)31)26(39)34-14-29(32)5-6-29/h7-10,12-13,27,40H,5-6,14-15H2,1-4H3,(H,34,39)	GZFXZQJKSZVCDY-UHFFFAOYSA-N	794525	US20260062387, Example 56	Serine/threonine-protein kinase SIK2	Homo sapiens		 16.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794525&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606040	528825988							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125871	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H29F3N6O4/c1-28(2,40)15-38-13-19(12-35-38)16-7-18(11-33)23-20(8-16)36-37(3)25(23)17-9-21(41-4)24(22(10-17)42-27(30)31)26(39)34-14-29(32)5-6-29/h7-10,12-13,27,40H,5-6,14-15H2,1-4H3,(H,34,39)	GZFXZQJKSZVCDY-UHFFFAOYSA-N	794525	US20260062387, Example 56	Serine/threonine-protein kinase SIK3	Homo sapiens		 11.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794525&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606040	528825988							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125872	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C28H27F3N6O4/c1-15(38)12-37-13-19(11-34-37)16-6-18(10-32)23-20(7-16)35-36(2)25(23)17-8-21(40-3)24(22(9-17)41-27(29)30)26(39)33-14-28(31)4-5-28/h6-9,11,13,15,27,38H,4-5,12,14H2,1-3H3,(H,33,39)	ATLGPKPCTSECNG-UHFFFAOYSA-N	794526	US20260062387, Example 57	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794526&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605974	528825989							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125873	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C28H27F3N6O4/c1-15(38)12-37-13-19(11-34-37)16-6-18(10-32)23-20(7-16)35-36(2)25(23)17-8-21(40-3)24(22(9-17)41-27(29)30)26(39)33-14-28(31)4-5-28/h6-9,11,13,15,27,38H,4-5,12,14H2,1-3H3,(H,33,39)	ATLGPKPCTSECNG-UHFFFAOYSA-N	794526	US20260062387, Example 57	Serine/threonine-protein kinase SIK2	Homo sapiens		 10.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794526&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605974	528825989							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125874	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C28H27F3N6O4/c1-15(38)12-37-13-19(11-34-37)16-6-18(10-32)23-20(7-16)35-36(2)25(23)17-8-21(40-3)24(22(9-17)41-27(29)30)26(39)33-14-28(31)4-5-28/h6-9,11,13,15,27,38H,4-5,12,14H2,1-3H3,(H,33,39)	ATLGPKPCTSECNG-UHFFFAOYSA-N	794526	US20260062387, Example 57	Serine/threonine-protein kinase SIK3	Homo sapiens		 9.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794526&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605974	528825989							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125875	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C28H27F3N6O4/c1-15(38)12-37-13-19(11-34-37)16-6-18(10-32)23-20(7-16)35-36(2)25(23)17-8-21(40-3)24(22(9-17)41-27(29)30)26(39)33-14-28(31)4-5-28/h6-9,11,13,15,27,38H,4-5,12,14H2,1-3H3,(H,33,39)	ATLGPKPCTSECNG-UHFFFAOYSA-N	794527	US20260062387, Example 58	Serine/threonine-protein kinase SIK1	Homo sapiens		 13.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794527&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605937	528825990							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125876	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C28H27F3N6O4/c1-15(38)12-37-13-19(11-34-37)16-6-18(10-32)23-20(7-16)35-36(2)25(23)17-8-21(40-3)24(22(9-17)41-27(29)30)26(39)33-14-28(31)4-5-28/h6-9,11,13,15,27,38H,4-5,12,14H2,1-3H3,(H,33,39)	ATLGPKPCTSECNG-UHFFFAOYSA-N	794527	US20260062387, Example 58	Serine/threonine-protein kinase SIK2	Homo sapiens		 6.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794527&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605937	528825990							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125877	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C28H27F3N6O4/c1-15(38)12-37-13-19(11-34-37)16-6-18(10-32)23-20(7-16)35-36(2)25(23)17-8-21(40-3)24(22(9-17)41-27(29)30)26(39)33-14-28(31)4-5-28/h6-9,11,13,15,27,38H,4-5,12,14H2,1-3H3,(H,33,39)	ATLGPKPCTSECNG-UHFFFAOYSA-N	794527	US20260062387, Example 58	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794527&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605937	528825990							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125878	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5COC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O4/c1-37-26(18-7-22(40-2)25(23(8-18)42-28(30)31)27(39)34-15-29(32)3-4-29)24-19(9-33)5-17(6-21(24)36-37)20-10-35-38(12-20)11-16-13-41-14-16/h5-8,10,12,16,28H,3-4,11,13-15H2,1-2H3,(H,34,39)	WBDQPCZEUITABQ-UHFFFAOYSA-N	794528	US20260062387, Example 59	Serine/threonine-protein kinase SIK1	Homo sapiens		 14.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794528&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606147	528825991							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125879	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5COC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O4/c1-37-26(18-7-22(40-2)25(23(8-18)42-28(30)31)27(39)34-15-29(32)3-4-29)24-19(9-33)5-17(6-21(24)36-37)20-10-35-38(12-20)11-16-13-41-14-16/h5-8,10,12,16,28H,3-4,11,13-15H2,1-2H3,(H,34,39)	WBDQPCZEUITABQ-UHFFFAOYSA-N	794528	US20260062387, Example 59	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794528&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606147	528825991							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125880	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5COC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O4/c1-37-26(18-7-22(40-2)25(23(8-18)42-28(30)31)27(39)34-15-29(32)3-4-29)24-19(9-33)5-17(6-21(24)36-37)20-10-35-38(12-20)11-16-13-41-14-16/h5-8,10,12,16,28H,3-4,11,13-15H2,1-2H3,(H,34,39)	WBDQPCZEUITABQ-UHFFFAOYSA-N	794528	US20260062387, Example 59	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794528&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606147	528825991							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125881	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H27F7N6O5/c1-39(2)21(43)11-42-10-16(9-37-42)14-5-17(25(30)31)22-18(6-14)38-40(3)24(22)15-7-19(46-4)23(20(8-15)47-27(32)33)26(44)41-12-28(45,13-41)29(34,35)36/h5-10,25,27,45H,11-13H2,1-4H3	RMCLCNAZVRJEOB-UHFFFAOYSA-N	794529	US20260062387, Example 60	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794529&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606118	528825992							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125882	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H27F7N6O5/c1-39(2)21(43)11-42-10-16(9-37-42)14-5-17(25(30)31)22-18(6-14)38-40(3)24(22)15-7-19(46-4)23(20(8-15)47-27(32)33)26(44)41-12-28(45,13-41)29(34,35)36/h5-10,25,27,45H,11-13H2,1-4H3	RMCLCNAZVRJEOB-UHFFFAOYSA-N	794529	US20260062387, Example 60	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794529&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606118	528825992							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125883	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C29H27F7N6O5/c1-39(2)21(43)11-42-10-16(9-37-42)14-5-17(25(30)31)22-18(6-14)38-40(3)24(22)15-7-19(46-4)23(20(8-15)47-27(32)33)26(44)41-12-28(45,13-41)29(34,35)36/h5-10,25,27,45H,11-13H2,1-4H3	RMCLCNAZVRJEOB-UHFFFAOYSA-N	794529	US20260062387, Example 60	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794529&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606118	528825992							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125884	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C29H28F6N6O5/c1-38(2)21(42)11-41-10-16(9-36-41)14-5-17(25(30)31)22-18(6-14)37-39(3)24(22)15-7-19(45-4)23(20(8-15)46-28(34)35)26(43)40-12-29(44,13-40)27(32)33/h5-10,25,27-28,44H,11-13H2,1-4H3	UECYPLLSPXQLHG-UHFFFAOYSA-N	794530	US20260062387, Example 61	Serine/threonine-protein kinase SIK1	Homo sapiens		 4.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794530&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606119	528825993							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125885	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C29H28F6N6O5/c1-38(2)21(42)11-41-10-16(9-36-41)14-5-17(25(30)31)22-18(6-14)37-39(3)24(22)15-7-19(45-4)23(20(8-15)46-28(34)35)26(43)40-12-29(44,13-40)27(32)33/h5-10,25,27-28,44H,11-13H2,1-4H3	UECYPLLSPXQLHG-UHFFFAOYSA-N	794530	US20260062387, Example 61	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794530&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606119	528825993							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125886	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C29H28F6N6O5/c1-38(2)21(42)11-41-10-16(9-36-41)14-5-17(25(30)31)22-18(6-14)37-39(3)24(22)15-7-19(45-4)23(20(8-15)46-28(34)35)26(43)40-12-29(44,13-40)27(32)33/h5-10,25,27-28,44H,11-13H2,1-4H3	UECYPLLSPXQLHG-UHFFFAOYSA-N	794530	US20260062387, Example 61	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794530&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606119	528825993							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125887	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H22F7N5O5/c1-36-9-14(8-34-36)12-4-15-19(17(5-12)42-23(27)28)21(37(2)35-15)13-6-16(41-3)20(18(7-13)43-24(29)30)22(39)38-10-25(40,11-38)26(31,32)33/h4-9,23-24,40H,10-11H2,1-3H3	ZTPHSLFBLSONKB-UHFFFAOYSA-N	794531	US20260062387, Example 62	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794531&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606075	528825994							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125888	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H22F7N5O5/c1-36-9-14(8-34-36)12-4-15-19(17(5-12)42-23(27)28)21(37(2)35-15)13-6-16(41-3)20(18(7-13)43-24(29)30)22(39)38-10-25(40,11-38)26(31,32)33/h4-9,23-24,40H,10-11H2,1-3H3	ZTPHSLFBLSONKB-UHFFFAOYSA-N	794531	US20260062387, Example 62	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794531&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606075	528825994							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125889	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C26H22F7N5O5/c1-36-9-14(8-34-36)12-4-15-19(17(5-12)42-23(27)28)21(37(2)35-15)13-6-16(41-3)20(18(7-13)43-24(29)30)22(39)38-10-25(40,11-38)26(31,32)33/h4-9,23-24,40H,10-11H2,1-3H3	ZTPHSLFBLSONKB-UHFFFAOYSA-N	794531	US20260062387, Example 62	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794531&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606075	528825994							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125890	COc1cc(-c2c3c(OC(F)F)cc(-c4cn(C)nn4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C25H22F6N6O5/c1-35-8-14(32-34-35)11-4-13-18(16(5-11)41-23(28)29)20(36(2)33-13)12-6-15(40-3)19(17(7-12)42-24(30)31)21(38)37-9-25(39,10-37)22(26)27/h4-8,22-24,39H,9-10H2,1-3H3	ORQWEHVJXZFLAY-UHFFFAOYSA-N	794532	US20260062387, Example 63	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794532&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605939	528825995							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125891	COc1cc(-c2c3c(OC(F)F)cc(-c4cn(C)nn4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C25H22F6N6O5/c1-35-8-14(32-34-35)11-4-13-18(16(5-11)41-23(28)29)20(36(2)33-13)12-6-15(40-3)19(17(7-12)42-24(30)31)21(38)37-9-25(39,10-37)22(26)27/h4-8,22-24,39H,9-10H2,1-3H3	ORQWEHVJXZFLAY-UHFFFAOYSA-N	794532	US20260062387, Example 63	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794532&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605939	528825995							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125892	COc1cc(-c2c3c(OC(F)F)cc(-c4cn(C)nn4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C25H22F6N6O5/c1-35-8-14(32-34-35)11-4-13-18(16(5-11)41-23(28)29)20(36(2)33-13)12-6-15(40-3)19(17(7-12)42-24(30)31)21(38)37-9-25(39,10-37)22(26)27/h4-8,22-24,39H,9-10H2,1-3H3	ORQWEHVJXZFLAY-UHFFFAOYSA-N	794532	US20260062387, Example 63	Serine/threonine-protein kinase SIK3	Homo sapiens		 9.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794532&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605939	528825995							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125893	COc1cc(-c2c3c(OC(F)F)cc(-c4cn(C)nn4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C25H22F6N6O5/c1-35-8-14(32-34-35)11-4-13-18(16(5-11)41-23(28)29)20(36(2)33-13)12-6-15(40-3)19(17(7-12)42-24(30)31)21(38)37-9-25(39,10-37)22(26)27/h4-8,22-24,39H,9-10H2,1-3H3	ORQWEHVJXZFLAY-UHFFFAOYSA-N	794533	US20260062387, Example 64	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794533&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605939	528825996							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125894	COc1cc(-c2c3c(OC(F)F)cc(-c4cn(C)nn4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C25H22F6N6O5/c1-35-8-14(32-34-35)11-4-13-18(16(5-11)41-23(28)29)20(36(2)33-13)12-6-15(40-3)19(17(7-12)42-24(30)31)21(38)37-9-25(39,10-37)22(26)27/h4-8,22-24,39H,9-10H2,1-3H3	ORQWEHVJXZFLAY-UHFFFAOYSA-N	794533	US20260062387, Example 64	Serine/threonine-protein kinase SIK2	Homo sapiens		 9.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794533&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605939	528825996							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125895	COc1cc(-c2c3c(OC(F)F)cc(-c4cn(C)nn4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C25H22F6N6O5/c1-35-8-14(32-34-35)11-4-13-18(16(5-11)41-23(28)29)20(36(2)33-13)12-6-15(40-3)19(17(7-12)42-24(30)31)21(38)37-9-25(39,10-37)22(26)27/h4-8,22-24,39H,9-10H2,1-3H3	ORQWEHVJXZFLAY-UHFFFAOYSA-N	794533	US20260062387, Example 64	Serine/threonine-protein kinase SIK3	Homo sapiens		 15.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794533&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605939	528825996							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125896	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CCC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H29F7N6O5/c1-40(2)22(44)5-6-43-12-17(11-38-43)15-7-18(26(31)32)23-19(8-15)39-41(3)25(23)16-9-20(47-4)24(21(10-16)48-28(33)34)27(45)42-13-29(46,14-42)30(35,36)37/h7-12,26,28,46H,5-6,13-14H2,1-4H3	MVKFQSSGOHTBLJ-UHFFFAOYSA-N	794534	US20260062387, Example 65	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794534&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606168	528825997							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125897	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CCC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H29F7N6O5/c1-40(2)22(44)5-6-43-12-17(11-38-43)15-7-18(26(31)32)23-19(8-15)39-41(3)25(23)16-9-20(47-4)24(21(10-16)48-28(33)34)27(45)42-13-29(46,14-42)30(35,36)37/h7-12,26,28,46H,5-6,13-14H2,1-4H3	MVKFQSSGOHTBLJ-UHFFFAOYSA-N	794534	US20260062387, Example 65	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794534&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606168	528825997							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125898	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CCC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C30H29F7N6O5/c1-40(2)22(44)5-6-43-12-17(11-38-43)15-7-18(26(31)32)23-19(8-15)39-41(3)25(23)16-9-20(47-4)24(21(10-16)48-28(33)34)27(45)42-13-29(46,14-42)30(35,36)37/h7-12,26,28,46H,5-6,13-14H2,1-4H3	MVKFQSSGOHTBLJ-UHFFFAOYSA-N	794534	US20260062387, Example 65	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794534&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606168	528825997							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125899	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CCS(C)(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C28H27F6N5O6S/c1-37-23(15-8-19(44-2)22(20(9-15)45-27(33)34)25(40)38-12-28(41,13-38)26(31)32)21-17(24(29)30)6-14(7-18(21)36-37)16-10-35-39(11-16)4-5-46(3,42)43/h6-11,24,26-27,41H,4-5,12-13H2,1-3H3	BVJGLYXRSNNDGX-UHFFFAOYSA-N	794535	US20260062387, Example 66	Serine/threonine-protein kinase SIK1	Homo sapiens		 11.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794535&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605926	528825998							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125900	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CCS(C)(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C28H27F6N5O6S/c1-37-23(15-8-19(44-2)22(20(9-15)45-27(33)34)25(40)38-12-28(41,13-38)26(31)32)21-17(24(29)30)6-14(7-18(21)36-37)16-10-35-39(11-16)4-5-46(3,42)43/h6-11,24,26-27,41H,4-5,12-13H2,1-3H3	BVJGLYXRSNNDGX-UHFFFAOYSA-N	794535	US20260062387, Example 66	Serine/threonine-protein kinase SIK2	Homo sapiens		 14.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794535&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605926	528825998							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125901	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CCS(C)(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C28H27F6N5O6S/c1-37-23(15-8-19(44-2)22(20(9-15)45-27(33)34)25(40)38-12-28(41,13-38)26(31)32)21-17(24(29)30)6-14(7-18(21)36-37)16-10-35-39(11-16)4-5-46(3,42)43/h6-11,24,26-27,41H,4-5,12-13H2,1-3H3	BVJGLYXRSNNDGX-UHFFFAOYSA-N	794535	US20260062387, Example 66	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794535&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605926	528825998							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125902	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)C1CC(O)(C(F)F)C1	InChI=1S/C29H28F6N4O5/c1-13(40)11-39-12-17(10-36-39)14-4-18(26(30)31)22-19(5-14)37-38(2)24(22)15-6-20(43-3)23(21(7-15)44-28(34)35)25(41)16-8-29(42,9-16)27(32)33/h4-7,10,12-13,16,26-28,40,42H,8-9,11H2,1-3H3	UBDRSIOKXXCVLA-UHFFFAOYSA-N	794536	US20260062387, Example 67	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794536&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			178423158	528825999							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125903	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)C1CC(O)(C(F)F)C1	InChI=1S/C29H28F6N4O5/c1-13(40)11-39-12-17(10-36-39)14-4-18(26(30)31)22-19(5-14)37-38(2)24(22)15-6-20(43-3)23(21(7-15)44-28(34)35)25(41)16-8-29(42,9-16)27(32)33/h4-7,10,12-13,16,26-28,40,42H,8-9,11H2,1-3H3	UBDRSIOKXXCVLA-UHFFFAOYSA-N	794536	US20260062387, Example 67	Serine/threonine-protein kinase SIK2	Homo sapiens		 12.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794536&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			178423158	528825999							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125904	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)C1CC(O)(C(F)F)C1	InChI=1S/C29H28F6N4O5/c1-13(40)11-39-12-17(10-36-39)14-4-18(26(30)31)22-19(5-14)37-38(2)24(22)15-6-20(43-3)23(21(7-15)44-28(34)35)25(41)16-8-29(42,9-16)27(32)33/h4-7,10,12-13,16,26-28,40,42H,8-9,11H2,1-3H3	UBDRSIOKXXCVLA-UHFFFAOYSA-N	794536	US20260062387, Example 67	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794536&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			178423158	528825999							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125905	COc1cc(-c2c3c(C(F)F)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C25H20F7N5O4/c1-36-20(18-14(21(26)27)3-11(4-15(18)35-36)13-7-33-34-8-13)12-5-16(40-2)19(17(6-12)41-23(28)29)22(38)37-9-24(39,10-37)25(30,31)32/h3-8,21,23,39H,9-10H2,1-2H3,(H,33,34)	JIRVBKZYYDTIRO-UHFFFAOYSA-N	794537	US20260062387, Example 68	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794537&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606121	528826000							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125906	COc1cc(-c2c3c(C(F)F)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C25H20F7N5O4/c1-36-20(18-14(21(26)27)3-11(4-15(18)35-36)13-7-33-34-8-13)12-5-16(40-2)19(17(6-12)41-23(28)29)22(38)37-9-24(39,10-37)25(30,31)32/h3-8,21,23,39H,9-10H2,1-2H3,(H,33,34)	JIRVBKZYYDTIRO-UHFFFAOYSA-N	794537	US20260062387, Example 68	Serine/threonine-protein kinase SIK2	Homo sapiens		 14.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794537&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606121	528826000							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125907	COc1cc(-c2c3c(C(F)F)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C25H20F7N5O4/c1-36-20(18-14(21(26)27)3-11(4-15(18)35-36)13-7-33-34-8-13)12-5-16(40-2)19(17(6-12)41-23(28)29)22(38)37-9-24(39,10-37)25(30,31)32/h3-8,21,23,39H,9-10H2,1-2H3,(H,33,34)	JIRVBKZYYDTIRO-UHFFFAOYSA-N	794537	US20260062387, Example 68	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794537&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606121	528826000							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125908	COc1cc(-c2c3c(C(F)F)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C25H21F6N5O4/c1-35-20(18-14(21(26)27)3-11(4-15(18)34-35)13-7-32-33-8-13)12-5-16(39-2)19(17(6-12)40-24(30)31)22(37)36-9-25(38,10-36)23(28)29/h3-8,21,23-24,38H,9-10H2,1-2H3,(H,32,33)	DCKDQSSJRDNGQR-UHFFFAOYSA-N	794538	US20260062387, Example 69	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794538&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606099	528826001							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125909	COc1cc(-c2c3c(C(F)F)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C25H21F6N5O4/c1-35-20(18-14(21(26)27)3-11(4-15(18)34-35)13-7-32-33-8-13)12-5-16(39-2)19(17(6-12)40-24(30)31)22(37)36-9-25(38,10-36)23(28)29/h3-8,21,23-24,38H,9-10H2,1-2H3,(H,32,33)	DCKDQSSJRDNGQR-UHFFFAOYSA-N	794538	US20260062387, Example 69	Serine/threonine-protein kinase SIK2	Homo sapiens		 10.9							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794538&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606099	528826001							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125910	COc1cc(-c2c3c(C(F)F)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)F)C1	InChI=1S/C25H21F6N5O4/c1-35-20(18-14(21(26)27)3-11(4-15(18)34-35)13-7-32-33-8-13)12-5-16(39-2)19(17(6-12)40-24(30)31)22(37)36-9-25(38,10-36)23(28)29/h3-8,21,23-24,38H,9-10H2,1-2H3,(H,32,33)	DCKDQSSJRDNGQR-UHFFFAOYSA-N	794538	US20260062387, Example 69	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794538&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606099	528826001							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125911	COc1cc(-c2c3c(C#N)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C25H19F5N6O4/c1-35-21(19-14(7-31)3-12(4-16(19)34-35)15-8-32-33-9-15)13-5-17(39-2)20(18(6-13)40-23(26)27)22(37)36-10-24(38,11-36)25(28,29)30/h3-6,8-9,23,38H,10-11H2,1-2H3,(H,32,33)	GKVIDKSHMDOPJZ-UHFFFAOYSA-N	794539	US20260062387, Example 70	Serine/threonine-protein kinase SIK1	Homo sapiens		 15.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794539&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606208	528826002							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125912	COc1cc(-c2c3c(C#N)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C25H19F5N6O4/c1-35-21(19-14(7-31)3-12(4-16(19)34-35)15-8-32-33-9-15)13-5-17(39-2)20(18(6-13)40-23(26)27)22(37)36-10-24(38,11-36)25(28,29)30/h3-6,8-9,23,38H,10-11H2,1-2H3,(H,32,33)	GKVIDKSHMDOPJZ-UHFFFAOYSA-N	794539	US20260062387, Example 70	Serine/threonine-protein kinase SIK2	Homo sapiens		 11.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794539&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606208	528826002							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125913	COc1cc(-c2c3c(C#N)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C25H19F5N6O4/c1-35-21(19-14(7-31)3-12(4-16(19)34-35)15-8-32-33-9-15)13-5-17(39-2)20(18(6-13)40-23(26)27)22(37)36-10-24(38,11-36)25(28,29)30/h3-6,8-9,23,38H,10-11H2,1-2H3,(H,32,33)	GKVIDKSHMDOPJZ-UHFFFAOYSA-N	794539	US20260062387, Example 70	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794539&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606208	528826002							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125914	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H26F7N5O5/c1-13(41)9-40-10-16(8-36-40)14-4-17(24(29)30)21-18(5-14)37-38(2)23(21)15-6-19(44-3)22(20(7-15)45-26(31)32)25(42)39-11-27(43,12-39)28(33,34)35/h4-8,10,13,24,26,41,43H,9,11-12H2,1-3H3	DOYPAWSQYJVDDX-UHFFFAOYSA-N	794540	US20260062387, Example 71	Serine/threonine-protein kinase SIK1	Homo sapiens		 3.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794540&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606058	528826003							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125915	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H26F7N5O5/c1-13(41)9-40-10-16(8-36-40)14-4-17(24(29)30)21-18(5-14)37-38(2)23(21)15-6-19(44-3)22(20(7-15)45-26(31)32)25(42)39-11-27(43,12-39)28(33,34)35/h4-8,10,13,24,26,41,43H,9,11-12H2,1-3H3	DOYPAWSQYJVDDX-UHFFFAOYSA-N	794540	US20260062387, Example 71	Serine/threonine-protein kinase SIK2	Homo sapiens		 6.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794540&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606058	528826003							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125916	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H26F7N5O5/c1-13(41)9-40-10-16(8-36-40)14-4-17(24(29)30)21-18(5-14)37-38(2)23(21)15-6-19(44-3)22(20(7-15)45-26(31)32)25(42)39-11-27(43,12-39)28(33,34)35/h4-8,10,13,24,26,41,43H,9,11-12H2,1-3H3	DOYPAWSQYJVDDX-UHFFFAOYSA-N	794540	US20260062387, Example 71	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794540&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606058	528826003							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125917	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H26F7N5O5/c1-13(41)9-40-10-16(8-36-40)14-4-17(24(29)30)21-18(5-14)37-38(2)23(21)15-6-19(44-3)22(20(7-15)45-26(31)32)25(42)39-11-27(43,12-39)28(33,34)35/h4-8,10,13,24,26,41,43H,9,11-12H2,1-3H3	DOYPAWSQYJVDDX-UHFFFAOYSA-N	794541	US20260062387, Example 72	Serine/threonine-protein kinase SIK1	Homo sapiens		 3.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794541&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606107	528826004							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125918	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H26F7N5O5/c1-13(41)9-40-10-16(8-36-40)14-4-17(24(29)30)21-18(5-14)37-38(2)23(21)15-6-19(44-3)22(20(7-15)45-26(31)32)25(42)39-11-27(43,12-39)28(33,34)35/h4-8,10,13,24,26,41,43H,9,11-12H2,1-3H3	DOYPAWSQYJVDDX-UHFFFAOYSA-N	794541	US20260062387, Example 72	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794541&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606107	528826004							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125919	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C28H26F7N5O5/c1-13(41)9-40-10-16(8-36-40)14-4-17(24(29)30)21-18(5-14)37-38(2)23(21)15-6-19(44-3)22(20(7-15)45-26(31)32)25(42)39-11-27(43,12-39)28(33,34)35/h4-8,10,13,24,26,41,43H,9,11-12H2,1-3H3	DOYPAWSQYJVDDX-UHFFFAOYSA-N	794541	US20260062387, Example 72	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794541&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606107	528826004							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125920	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H18F2N6O3/c1-29-10-14(9-27-29)11-4-13(8-25)18-15(5-11)28-30(2)20(18)12-6-16(32-3)19(21(26)31)17(7-12)33-22(23)24/h4-7,9-10,22H,1-3H3,(H2,26,31)	DCRMEKYYYXCFBV-UHFFFAOYSA-N	794542	US20260062387, Example 73	Serine/threonine-protein kinase SIK1	Homo sapiens		 17.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794542&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605932	528826005							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125921	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H18F2N6O3/c1-29-10-14(9-27-29)11-4-13(8-25)18-15(5-11)28-30(2)20(18)12-6-16(32-3)19(21(26)31)17(7-12)33-22(23)24/h4-7,9-10,22H,1-3H3,(H2,26,31)	DCRMEKYYYXCFBV-UHFFFAOYSA-N	794542	US20260062387, Example 73	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794542&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605932	528826005							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125922	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H18F2N6O3/c1-29-10-14(9-27-29)11-4-13(8-25)18-15(5-11)28-30(2)20(18)12-6-16(32-3)19(21(26)31)17(7-12)33-22(23)24/h4-7,9-10,22H,1-3H3,(H2,26,31)	DCRMEKYYYXCFBV-UHFFFAOYSA-N	794542	US20260062387, Example 73	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794542&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605932	528826005							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125923	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CS(=O)(=O)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O5S/c1-37-26(18-7-22(42-2)25(23(8-18)43-28(30)31)27(39)34-15-29(32)3-4-29)24-19(9-33)5-17(6-21(24)36-37)20-10-35-38(12-20)11-16-13-44(40,41)14-16/h5-8,10,12,16,28H,3-4,11,13-15H2,1-2H3,(H,34,39)	XBKRQUQLMCXEKB-UHFFFAOYSA-N	794543	US20260062387, Example 74	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794543&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606151	528826006							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125924	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CS(=O)(=O)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O5S/c1-37-26(18-7-22(42-2)25(23(8-18)43-28(30)31)27(39)34-15-29(32)3-4-29)24-19(9-33)5-17(6-21(24)36-37)20-10-35-38(12-20)11-16-13-44(40,41)14-16/h5-8,10,12,16,28H,3-4,11,13-15H2,1-2H3,(H,34,39)	XBKRQUQLMCXEKB-UHFFFAOYSA-N	794543	US20260062387, Example 74	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794543&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606151	528826006							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125925	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CS(=O)(=O)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O5S/c1-37-26(18-7-22(42-2)25(23(8-18)43-28(30)31)27(39)34-15-29(32)3-4-29)24-19(9-33)5-17(6-21(24)36-37)20-10-35-38(12-20)11-16-13-44(40,41)14-16/h5-8,10,12,16,28H,3-4,11,13-15H2,1-2H3,(H,34,39)	XBKRQUQLMCXEKB-UHFFFAOYSA-N	794543	US20260062387, Example 74	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794543&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606151	528826006							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125926	COc1cc(-c2c3c(C#N)cc(-c4cnn(Cc5ncco5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H24F3N7O4/c1-38-26(17-9-21(41-2)25(22(10-17)43-28(30)31)27(40)35-15-29(32)3-4-29)24-18(11-33)7-16(8-20(24)37-38)19-12-36-39(13-19)14-23-34-5-6-42-23/h5-10,12-13,28H,3-4,14-15H2,1-2H3,(H,35,40)	OYXBDAZGZMTQEB-UHFFFAOYSA-N	794544	US20260062387, Example 75	Serine/threonine-protein kinase SIK1	Homo sapiens		 14.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794544&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606076	528826007							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125927	COc1cc(-c2c3c(C#N)cc(-c4cnn(Cc5ncco5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H24F3N7O4/c1-38-26(17-9-21(41-2)25(22(10-17)43-28(30)31)27(40)35-15-29(32)3-4-29)24-18(11-33)7-16(8-20(24)37-38)19-12-36-39(13-19)14-23-34-5-6-42-23/h5-10,12-13,28H,3-4,14-15H2,1-2H3,(H,35,40)	OYXBDAZGZMTQEB-UHFFFAOYSA-N	794544	US20260062387, Example 75	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794544&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606076	528826007							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125928	COc1cc(-c2c3c(C#N)cc(-c4cnn(Cc5ncco5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H24F3N7O4/c1-38-26(17-9-21(41-2)25(22(10-17)43-28(30)31)27(40)35-15-29(32)3-4-29)24-18(11-33)7-16(8-20(24)37-38)19-12-36-39(13-19)14-23-34-5-6-42-23/h5-10,12-13,28H,3-4,14-15H2,1-2H3,(H,35,40)	OYXBDAZGZMTQEB-UHFFFAOYSA-N	794544	US20260062387, Example 75	Serine/threonine-protein kinase SIK3	Homo sapiens		 13.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794544&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606076	528826007							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125929	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(F)COC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H26F4N6O4/c1-38-25(17-7-21(41-2)24(22(8-17)43-27(30)31)26(40)35-12-28(32)3-4-28)23-18(9-34)5-16(6-20(23)37-38)19-10-36-39(11-19)13-29(33)14-42-15-29/h5-8,10-11,27H,3-4,12-15H2,1-2H3,(H,35,40)	SCAYACMHOOSWGA-UHFFFAOYSA-N	794545	US20260062387, Example 76	Serine/threonine-protein kinase SIK1	Homo sapiens		 17.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794545&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605953	528826008							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125930	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(F)COC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H26F4N6O4/c1-38-25(17-7-21(41-2)24(22(8-17)43-27(30)31)26(40)35-12-28(32)3-4-28)23-18(9-34)5-16(6-20(23)37-38)19-10-36-39(11-19)13-29(33)14-42-15-29/h5-8,10-11,27H,3-4,12-15H2,1-2H3,(H,35,40)	SCAYACMHOOSWGA-UHFFFAOYSA-N	794545	US20260062387, Example 76	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794545&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605953	528826008							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125931	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(F)COC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H26F4N6O4/c1-38-25(17-7-21(41-2)24(22(8-17)43-27(30)31)26(40)35-12-28(32)3-4-28)23-18(9-34)5-16(6-20(23)37-38)19-10-36-39(11-19)13-29(33)14-42-15-29/h5-8,10-11,27H,3-4,12-15H2,1-2H3,(H,35,40)	SCAYACMHOOSWGA-UHFFFAOYSA-N	794545	US20260062387, Example 76	Serine/threonine-protein kinase SIK3	Homo sapiens		 11.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794545&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605953	528826008							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125932	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NCC2C	InChI=1S/C24H22N6O2/c1-13-10-26-24(31)22-18(13)6-15(8-20(22)32-4)23-21-16(9-25)5-14(7-19(21)28-30(23)3)17-11-27-29(2)12-17/h5-8,11-13H,10H2,1-4H3,(H,26,31)	IARJLDUYBCTALD-UHFFFAOYSA-N	794546	US20260062387, Example 77	Serine/threonine-protein kinase SIK1	Homo sapiens		 11.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794546&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606138	528826009							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125933	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NCC2C	InChI=1S/C24H22N6O2/c1-13-10-26-24(31)22-18(13)6-15(8-20(22)32-4)23-21-16(9-25)5-14(7-19(21)28-30(23)3)17-11-27-29(2)12-17/h5-8,11-13H,10H2,1-4H3,(H,26,31)	IARJLDUYBCTALD-UHFFFAOYSA-N	794546	US20260062387, Example 77	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794546&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606138	528826009							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125934	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NCC2C	InChI=1S/C24H22N6O2/c1-13-10-26-24(31)22-18(13)6-15(8-20(22)32-4)23-21-16(9-25)5-14(7-19(21)28-30(23)3)17-11-27-29(2)12-17/h5-8,11-13H,10H2,1-4H3,(H,26,31)	IARJLDUYBCTALD-UHFFFAOYSA-N	794546	US20260062387, Example 77	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794546&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606138	528826009							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125935	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-27(19-9-23(41-2)26(24(10-19)43-29(31)32)28(40)35-16-30(33)4-5-30)25-20(11-34)7-18(8-22(25)37-38)21-12-36-39(14-21)13-17-3-6-42-15-17/h7-10,12,14,17,29H,3-6,13,15-16H2,1-2H3,(H,35,40)	JWGSUPLOJMYLKK-UHFFFAOYSA-N	794547	US20260062387, Example 78	Serine/threonine-protein kinase SIK1	Homo sapiens		 12.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794547&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605980	528826010							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125936	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-27(19-9-23(41-2)26(24(10-19)43-29(31)32)28(40)35-16-30(33)4-5-30)25-20(11-34)7-18(8-22(25)37-38)21-12-36-39(14-21)13-17-3-6-42-15-17/h7-10,12,14,17,29H,3-6,13,15-16H2,1-2H3,(H,35,40)	JWGSUPLOJMYLKK-UHFFFAOYSA-N	794547	US20260062387, Example 78	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794547&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605980	528826010							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125937	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-27(19-9-23(41-2)26(24(10-19)43-29(31)32)28(40)35-16-30(33)4-5-30)25-20(11-34)7-18(8-22(25)37-38)21-12-36-39(14-21)13-17-3-6-42-15-17/h7-10,12,14,17,29H,3-6,13,15-16H2,1-2H3,(H,35,40)	JWGSUPLOJMYLKK-UHFFFAOYSA-N	794547	US20260062387, Example 78	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794547&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605980	528826010							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125938	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCCO5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-27(18-10-23(41-2)26(24(11-18)43-29(31)32)28(40)35-16-30(33)5-6-30)25-19(12-34)8-17(9-22(25)37-38)20-13-36-39(14-20)15-21-4-3-7-42-21/h8-11,13-14,21,29H,3-7,15-16H2,1-2H3,(H,35,40)	DAKWSELUDBKKAY-UHFFFAOYSA-N	794548	US20260062387, Example 79	Serine/threonine-protein kinase SIK1	Homo sapiens		 12.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794548&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605990	528826011							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125939	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCCO5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-27(18-10-23(41-2)26(24(11-18)43-29(31)32)28(40)35-16-30(33)5-6-30)25-19(12-34)8-17(9-22(25)37-38)20-13-36-39(14-20)15-21-4-3-7-42-21/h8-11,13-14,21,29H,3-7,15-16H2,1-2H3,(H,35,40)	DAKWSELUDBKKAY-UHFFFAOYSA-N	794548	US20260062387, Example 79	Serine/threonine-protein kinase SIK2	Homo sapiens		 6.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794548&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605990	528826011							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125940	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCCO5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-27(18-10-23(41-2)26(24(11-18)43-29(31)32)28(40)35-16-30(33)5-6-30)25-19(12-34)8-17(9-22(25)37-38)20-13-36-39(14-20)15-21-4-3-7-42-21/h8-11,13-14,21,29H,3-7,15-16H2,1-2H3,(H,35,40)	DAKWSELUDBKKAY-UHFFFAOYSA-N	794548	US20260062387, Example 79	Serine/threonine-protein kinase SIK3	Homo sapiens		 8.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794548&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605990	528826011							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125941	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCO5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O4/c1-37-26(17-9-22(40-2)25(23(10-17)42-28(30)31)27(39)34-15-29(32)4-5-29)24-18(11-33)7-16(8-21(24)36-37)19-12-35-38(13-19)14-20-3-6-41-20/h7-10,12-13,20,28H,3-6,14-15H2,1-2H3,(H,34,39)	WXQPYUIWBVQAJB-UHFFFAOYSA-N	794549	US20260062387, Example 80	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794549&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606104	528826012							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125942	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCO5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O4/c1-37-26(17-9-22(40-2)25(23(10-17)42-28(30)31)27(39)34-15-29(32)4-5-29)24-18(11-33)7-16(8-21(24)36-37)19-12-35-38(13-19)14-20-3-6-41-20/h7-10,12-13,20,28H,3-6,14-15H2,1-2H3,(H,34,39)	WXQPYUIWBVQAJB-UHFFFAOYSA-N	794549	US20260062387, Example 80	Serine/threonine-protein kinase SIK2	Homo sapiens		 8.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794549&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606104	528826012							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125943	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCO5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O4/c1-37-26(17-9-22(40-2)25(23(10-17)42-28(30)31)27(39)34-15-29(32)4-5-29)24-18(11-33)7-16(8-21(24)36-37)19-12-35-38(13-19)14-20-3-6-41-20/h7-10,12-13,20,28H,3-6,14-15H2,1-2H3,(H,34,39)	WXQPYUIWBVQAJB-UHFFFAOYSA-N	794549	US20260062387, Example 80	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794549&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606104	528826012							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125944	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCS5(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O5S/c1-37-26(17-9-22(42-2)25(23(10-17)43-28(30)31)27(39)34-15-29(32)4-5-29)24-18(11-33)7-16(8-21(24)36-37)19-12-35-38(13-19)14-20-3-6-44(20,40)41/h7-10,12-13,20,28H,3-6,14-15H2,1-2H3,(H,34,39)	XRQBJHXIDMNVSU-UHFFFAOYSA-N	794550	US20260062387, Example 81	Serine/threonine-protein kinase SIK1	Homo sapiens		 13.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794550&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606192	528826013							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125945	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCS5(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O5S/c1-37-26(17-9-22(42-2)25(23(10-17)43-28(30)31)27(39)34-15-29(32)4-5-29)24-18(11-33)7-16(8-21(24)36-37)19-12-35-38(13-19)14-20-3-6-44(20,40)41/h7-10,12-13,20,28H,3-6,14-15H2,1-2H3,(H,34,39)	XRQBJHXIDMNVSU-UHFFFAOYSA-N	794550	US20260062387, Example 81	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794550&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606192	528826013							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125946	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCS5(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O5S/c1-37-26(17-9-22(42-2)25(23(10-17)43-28(30)31)27(39)34-15-29(32)4-5-29)24-18(11-33)7-16(8-21(24)36-37)19-12-35-38(13-19)14-20-3-6-44(20,40)41/h7-10,12-13,20,28H,3-6,14-15H2,1-2H3,(H,34,39)	XRQBJHXIDMNVSU-UHFFFAOYSA-N	794550	US20260062387, Example 81	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794550&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606192	528826013							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125947	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCCS5(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O5S/c1-38-27(18-10-23(43-2)26(24(11-18)44-29(31)32)28(40)35-16-30(33)5-6-30)25-19(12-34)8-17(9-22(25)37-38)20-13-36-39(14-20)15-21-4-3-7-45(21,41)42/h8-11,13-14,21,29H,3-7,15-16H2,1-2H3,(H,35,40)	WAZLVQYGAOYJRN-UHFFFAOYSA-N	794551	US20260062387, Example 82	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794551&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606041	528826014							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125948	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCCS5(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O5S/c1-38-27(18-10-23(43-2)26(24(11-18)44-29(31)32)28(40)35-16-30(33)5-6-30)25-19(12-34)8-17(9-22(25)37-38)20-13-36-39(14-20)15-21-4-3-7-45(21,41)42/h8-11,13-14,21,29H,3-7,15-16H2,1-2H3,(H,35,40)	WAZLVQYGAOYJRN-UHFFFAOYSA-N	794551	US20260062387, Example 82	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794551&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606041	528826014							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125949	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CCCS5(=O)=O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O5S/c1-38-27(18-10-23(43-2)26(24(11-18)44-29(31)32)28(40)35-16-30(33)5-6-30)25-19(12-34)8-17(9-22(25)37-38)20-13-36-39(14-20)15-21-4-3-7-45(21,41)42/h8-11,13-14,21,29H,3-7,15-16H2,1-2H3,(H,35,40)	WAZLVQYGAOYJRN-UHFFFAOYSA-N	794551	US20260062387, Example 82	Serine/threonine-protein kinase SIK3	Homo sapiens		 16.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794551&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606041	528826014							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125950	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(O)CC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O4/c1-37-25(17-9-21(41-2)24(22(10-17)42-27(30)31)26(39)34-14-28(32)3-4-28)23-18(11-33)7-16(8-20(23)36-37)19-12-35-38(13-19)15-29(40)5-6-29/h7-10,12-13,27,40H,3-6,14-15H2,1-2H3,(H,34,39)	ZJGZVBDOXFSBFA-UHFFFAOYSA-N	794552	US20260062387, Example 83	Serine/threonine-protein kinase SIK1	Homo sapiens		 10.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794552&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605960	528826015							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125951	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(O)CC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O4/c1-37-25(17-9-21(41-2)24(22(10-17)42-27(30)31)26(39)34-14-28(32)3-4-28)23-18(11-33)7-16(8-20(23)36-37)19-12-35-38(13-19)15-29(40)5-6-29/h7-10,12-13,27,40H,3-6,14-15H2,1-2H3,(H,34,39)	ZJGZVBDOXFSBFA-UHFFFAOYSA-N	794552	US20260062387, Example 83	Serine/threonine-protein kinase SIK2	Homo sapiens		 8.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794552&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605960	528826015							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125952	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(O)CC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H27F3N6O4/c1-37-25(17-9-21(41-2)24(22(10-17)42-27(30)31)26(39)34-14-28(32)3-4-28)23-18(11-33)7-16(8-20(23)36-37)19-12-35-38(13-19)15-29(40)5-6-29/h7-10,12-13,27,40H,3-6,14-15H2,1-2H3,(H,34,39)	ZJGZVBDOXFSBFA-UHFFFAOYSA-N	794552	US20260062387, Example 83	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794552&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605960	528826015							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125953	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-26(18-10-22(42-2)25(23(11-18)43-28(31)32)27(40)35-15-29(33)6-7-29)24-19(12-34)8-17(9-21(24)37-38)20-13-36-39(14-20)16-30(41)4-3-5-30/h8-11,13-14,28,41H,3-7,15-16H2,1-2H3,(H,35,40)	VYZQXGYOCKVEHT-UHFFFAOYSA-N	794553	US20260062387, Example 84	Serine/threonine-protein kinase SIK1	Homo sapiens		 13.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794553&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605948	528826016							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125954	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-26(18-10-22(42-2)25(23(11-18)43-28(31)32)27(40)35-15-29(33)6-7-29)24-19(12-34)8-17(9-21(24)37-38)20-13-36-39(14-20)16-30(41)4-3-5-30/h8-11,13-14,28,41H,3-7,15-16H2,1-2H3,(H,35,40)	VYZQXGYOCKVEHT-UHFFFAOYSA-N	794553	US20260062387, Example 84	Serine/threonine-protein kinase SIK2	Homo sapiens		 11.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794553&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605948	528826016							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125955	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-26(18-10-22(42-2)25(23(11-18)43-28(31)32)27(40)35-15-29(33)6-7-29)24-19(12-34)8-17(9-21(24)37-38)20-13-36-39(14-20)16-30(41)4-3-5-30/h8-11,13-14,28,41H,3-7,15-16H2,1-2H3,(H,35,40)	VYZQXGYOCKVEHT-UHFFFAOYSA-N	794553	US20260062387, Example 84	Serine/threonine-protein kinase SIK3	Homo sapiens		 12.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794553&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605948	528826016							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125956	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCN5CCOCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C31H31F4N7O4/c1-40-28(19-11-24(44-2)27(25(12-19)46-30(32)33)29(43)37-16-22-13-31(22,34)35)26-20(14-36)9-18(10-23(26)39-40)21-15-38-42(17-21)4-3-41-5-7-45-8-6-41/h9-12,15,17,22,30H,3-8,13,16H2,1-2H3,(H,37,43)	ZLBIQNKYCZQNLF-UHFFFAOYSA-N	794554	US20260062387, Example 85	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794554&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			178423159	528826017							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125957	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCN5CCOCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C31H31F4N7O4/c1-40-28(19-11-24(44-2)27(25(12-19)46-30(32)33)29(43)37-16-22-13-31(22,34)35)26-20(14-36)9-18(10-23(26)39-40)21-15-38-42(17-21)4-3-41-5-7-45-8-6-41/h9-12,15,17,22,30H,3-8,13,16H2,1-2H3,(H,37,43)	ZLBIQNKYCZQNLF-UHFFFAOYSA-N	794554	US20260062387, Example 85	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794554&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			178423159	528826017							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125958	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCN5CCOCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C31H31F4N7O4/c1-40-28(19-11-24(44-2)27(25(12-19)46-30(32)33)29(43)37-16-22-13-31(22,34)35)26-20(14-36)9-18(10-23(26)39-40)21-15-38-42(17-21)4-3-41-5-7-45-8-6-41/h9-12,15,17,22,30H,3-8,13,16H2,1-2H3,(H,37,43)	ZLBIQNKYCZQNLF-UHFFFAOYSA-N	794554	US20260062387, Example 85	Serine/threonine-protein kinase SIK3	Homo sapiens		 8.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794554&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			178423159	528826017							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125959	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C29H28F4N6O4/c1-28(2,41)14-39-13-18(11-36-39)15-5-17(10-34)23-20(6-15)37-38(3)25(23)16-7-21(42-4)24(22(8-16)43-27(30)31)26(40)35-12-19-9-29(19,32)33/h5-8,11,13,19,27,41H,9,12,14H2,1-4H3,(H,35,40)	ROWZCPZCSBRFLC-UHFFFAOYSA-N	794555	US20260062387, Example 86	Serine/threonine-protein kinase SIK1	Homo sapiens		 13.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794555&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			178423160	528826018							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125960	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C29H28F4N6O4/c1-28(2,41)14-39-13-18(11-36-39)15-5-17(10-34)23-20(6-15)37-38(3)25(23)16-7-21(42-4)24(22(8-16)43-27(30)31)26(40)35-12-19-9-29(19,32)33/h5-8,11,13,19,27,41H,9,12,14H2,1-4H3,(H,35,40)	ROWZCPZCSBRFLC-UHFFFAOYSA-N	794555	US20260062387, Example 86	Serine/threonine-protein kinase SIK2	Homo sapiens		 13.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794555&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			178423160	528826018							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125961	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C29H28F4N6O4/c1-28(2,41)14-39-13-18(11-36-39)15-5-17(10-34)23-20(6-15)37-38(3)25(23)16-7-21(42-4)24(22(8-16)43-27(30)31)26(40)35-12-19-9-29(19,32)33/h5-8,11,13,19,27,41H,9,12,14H2,1-4H3,(H,35,40)	ROWZCPZCSBRFLC-UHFFFAOYSA-N	794555	US20260062387, Example 86	Serine/threonine-protein kinase SIK3	Homo sapiens		 19.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794555&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			178423160	528826018							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125962	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H19F4N5O3/c1-30-9-12(8-28-30)10-4-13(20(23)24)17-14(5-10)29-31(2)19(17)11-6-15(33-3)18(21(27)32)16(7-11)34-22(25)26/h4-9,20,22H,1-3H3,(H2,27,32)	PVKYFGJNKQTGIJ-UHFFFAOYSA-N	794556	US20260062387, Example 87	Serine/threonine-protein kinase SIK1	Homo sapiens		 18.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794556&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606218	528826019							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125963	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H19F4N5O3/c1-30-9-12(8-28-30)10-4-13(20(23)24)17-14(5-10)29-31(2)19(17)11-6-15(33-3)18(21(27)32)16(7-11)34-22(25)26/h4-9,20,22H,1-3H3,(H2,27,32)	PVKYFGJNKQTGIJ-UHFFFAOYSA-N	794556	US20260062387, Example 87	Serine/threonine-protein kinase SIK2	Homo sapiens		 14.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794556&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606218	528826019							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125964	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H19F4N5O3/c1-30-9-12(8-28-30)10-4-13(20(23)24)17-14(5-10)29-31(2)19(17)11-6-15(33-3)18(21(27)32)16(7-11)34-22(25)26/h4-9,20,22H,1-3H3,(H2,27,32)	PVKYFGJNKQTGIJ-UHFFFAOYSA-N	794556	US20260062387, Example 87	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794556&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606218	528826019							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125965	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C24H22N6O2/c1-13-10-26-24(31)22-18(13)6-15(8-20(22)32-4)23-21-16(9-25)5-14(7-19(21)28-30(23)3)17-11-27-29(2)12-17/h5-8,11-13H,10H2,1-4H3,(H,26,31)	IARJLDUYBCTALD-UHFFFAOYSA-N	794557	US20260062387, Example 88	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794557&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606139	528826020							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125966	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C24H22N6O2/c1-13-10-26-24(31)22-18(13)6-15(8-20(22)32-4)23-21-16(9-25)5-14(7-19(21)28-30(23)3)17-11-27-29(2)12-17/h5-8,11-13H,10H2,1-4H3,(H,26,31)	IARJLDUYBCTALD-UHFFFAOYSA-N	794557	US20260062387, Example 88	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794557&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606139	528826020							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125967	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C24H22N6O2/c1-13-10-26-24(31)22-18(13)6-15(8-20(22)32-4)23-21-16(9-25)5-14(7-19(21)28-30(23)3)17-11-27-29(2)12-17/h5-8,11-13H,10H2,1-4H3,(H,26,31)	IARJLDUYBCTALD-UHFFFAOYSA-N	794557	US20260062387, Example 88	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794557&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606139	528826020							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125968	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H25F6N5O4/c1-12(39)10-38-11-15(9-34-38)13-4-16(24(28)29)21-17(5-13)36-37(2)23(21)14-6-18(41-3)22(19(7-14)42-26(30)31)25(40)35-20-8-27(20,32)33/h4-7,9,11-12,20,24,26,39H,8,10H2,1-3H3,(H,35,40)	CNUJYRIIJJHXRZ-UHFFFAOYSA-N	794558	US20260062387, Example 89	Serine/threonine-protein kinase SIK1	Homo sapiens		 11.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794558&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606100	528826021							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125969	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H25F6N5O4/c1-12(39)10-38-11-15(9-34-38)13-4-16(24(28)29)21-17(5-13)36-37(2)23(21)14-6-18(41-3)22(19(7-14)42-26(30)31)25(40)35-20-8-27(20,32)33/h4-7,9,11-12,20,24,26,39H,8,10H2,1-3H3,(H,35,40)	CNUJYRIIJJHXRZ-UHFFFAOYSA-N	794558	US20260062387, Example 89	Serine/threonine-protein kinase SIK2	Homo sapiens		 12.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794558&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606100	528826021							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125970	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H25F6N5O4/c1-12(39)10-38-11-15(9-34-38)13-4-16(24(28)29)21-17(5-13)36-37(2)23(21)14-6-18(41-3)22(19(7-14)42-26(30)31)25(40)35-20-8-27(20,32)33/h4-7,9,11-12,20,24,26,39H,8,10H2,1-3H3,(H,35,40)	CNUJYRIIJJHXRZ-UHFFFAOYSA-N	794558	US20260062387, Example 89	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794558&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606100	528826021							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125971	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H31F3N6O4/c1-29(2,41)7-8-39-15-20(14-36-39)17-9-19(13-34)24-21(10-17)37-38(3)26(24)18-11-22(42-4)25(23(12-18)43-28(31)32)27(40)35-16-30(33)5-6-30/h9-12,14-15,28,41H,5-8,16H2,1-4H3,(H,35,40)	NWFUHGOZBVAEBK-UHFFFAOYSA-N	794559	US20260062387, Example 90	Serine/threonine-protein kinase SIK1	Homo sapiens		 17.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794559&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606073	528826022							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125972	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H31F3N6O4/c1-29(2,41)7-8-39-15-20(14-36-39)17-9-19(13-34)24-21(10-17)37-38(3)26(24)18-11-22(42-4)25(23(12-18)43-28(31)32)27(40)35-16-30(33)5-6-30/h9-12,14-15,28,41H,5-8,16H2,1-4H3,(H,35,40)	NWFUHGOZBVAEBK-UHFFFAOYSA-N	794559	US20260062387, Example 90	Serine/threonine-protein kinase SIK2	Homo sapiens		 10.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794559&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606073	528826022							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125973	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H31F3N6O4/c1-29(2,41)7-8-39-15-20(14-36-39)17-9-19(13-34)24-21(10-17)37-38(3)26(24)18-11-22(42-4)25(23(12-18)43-28(31)32)27(40)35-16-30(33)5-6-30/h9-12,14-15,28,41H,5-8,16H2,1-4H3,(H,35,40)	NWFUHGOZBVAEBK-UHFFFAOYSA-N	794559	US20260062387, Example 90	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794559&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606073	528826022							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125974	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H]5C[C@@H](O)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-27(18-9-23(42-2)26(24(10-18)43-29(31)32)28(41)35-15-30(33)3-4-30)25-19(11-34)7-17(8-22(25)37-38)20-12-36-39(14-20)13-16-5-21(40)6-16/h7-10,12,14,16,21,29,40H,3-6,13,15H2,1-2H3,(H,35,41)	KFWOJUGOJMLDJD-UHFFFAOYSA-N	794560	US20260062387, Example 91	Serine/threonine-protein kinase SIK1	Homo sapiens		 17.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794560&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606025	528826023							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125975	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H]5C[C@@H](O)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-27(18-9-23(42-2)26(24(10-18)43-29(31)32)28(41)35-15-30(33)3-4-30)25-19(11-34)7-17(8-22(25)37-38)20-12-36-39(14-20)13-16-5-21(40)6-16/h7-10,12,14,16,21,29,40H,3-6,13,15H2,1-2H3,(H,35,41)	KFWOJUGOJMLDJD-UHFFFAOYSA-N	794560	US20260062387, Example 91	Serine/threonine-protein kinase SIK2	Homo sapiens		 10.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794560&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606025	528826023							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125976	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H]5C[C@@H](O)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H29F3N6O4/c1-38-27(18-9-23(42-2)26(24(10-18)43-29(31)32)28(41)35-15-30(33)3-4-30)25-19(11-34)7-17(8-22(25)37-38)20-12-36-39(14-20)13-16-5-21(40)6-16/h7-10,12,14,16,21,29,40H,3-6,13,15H2,1-2H3,(H,35,41)	KFWOJUGOJMLDJD-UHFFFAOYSA-N	794560	US20260062387, Example 91	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794560&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606025	528826023							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125977	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H29F3N6O4/c1-16(39)4-7-38-14-20(13-35-38)17-8-19(12-33)24-21(9-17)36-37(2)26(24)18-10-22(41-3)25(23(11-18)42-28(30)31)27(40)34-15-29(32)5-6-29/h8-11,13-14,16,28,39H,4-7,15H2,1-3H3,(H,34,40)	OQQZYIQMXFCMGW-UHFFFAOYSA-N	794561	US20260062387, Example 92	Serine/threonine-protein kinase SIK1	Homo sapiens		 17.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794561&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606164	528826024							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125978	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H29F3N6O4/c1-16(39)4-7-38-14-20(13-35-38)17-8-19(12-33)24-21(9-17)36-37(2)26(24)18-10-22(41-3)25(23(11-18)42-28(30)31)27(40)34-15-29(32)5-6-29/h8-11,13-14,16,28,39H,4-7,15H2,1-3H3,(H,34,40)	OQQZYIQMXFCMGW-UHFFFAOYSA-N	794561	US20260062387, Example 92	Serine/threonine-protein kinase SIK2	Homo sapiens		 10.9							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794561&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606164	528826024							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125979	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H29F3N6O4/c1-16(39)4-7-38-14-20(13-35-38)17-8-19(12-33)24-21(9-17)36-37(2)26(24)18-10-22(41-3)25(23(11-18)42-28(30)31)27(40)34-15-29(32)5-6-29/h8-11,13-14,16,28,39H,4-7,15H2,1-3H3,(H,34,40)	OQQZYIQMXFCMGW-UHFFFAOYSA-N	794561	US20260062387, Example 92	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794561&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606164	528826024							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125980	CC[C@H](O)Cn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(=O)NCC5(F)CC5)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C29H29F3N6O4/c1-4-20(39)14-38-13-19(12-35-38)16-7-18(11-33)24-21(8-16)36-37(2)26(24)17-9-22(41-3)25(23(10-17)42-28(30)31)27(40)34-15-29(32)5-6-29/h7-10,12-13,20,28,39H,4-6,14-15H2,1-3H3,(H,34,40)	WWHYYLLELVGLKH-UHFFFAOYSA-N	794562	US20260062387, Example 93	Serine/threonine-protein kinase SIK1	Homo sapiens		 19.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794562&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606016	528826025							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125981	CC[C@H](O)Cn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(=O)NCC5(F)CC5)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C29H29F3N6O4/c1-4-20(39)14-38-13-19(12-35-38)16-7-18(11-33)24-21(8-16)36-37(2)26(24)17-9-22(41-3)25(23(10-17)42-28(30)31)27(40)34-15-29(32)5-6-29/h7-10,12-13,20,28,39H,4-6,14-15H2,1-3H3,(H,34,40)	WWHYYLLELVGLKH-UHFFFAOYSA-N	794562	US20260062387, Example 93	Serine/threonine-protein kinase SIK2	Homo sapiens		 13.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794562&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606016	528826025							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125982	CC[C@H](O)Cn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(=O)NCC5(F)CC5)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C29H29F3N6O4/c1-4-20(39)14-38-13-19(12-35-38)16-7-18(11-33)24-21(8-16)36-37(2)26(24)17-9-22(41-3)25(23(10-17)42-28(30)31)27(40)34-15-29(32)5-6-29/h7-10,12-13,20,28,39H,4-6,14-15H2,1-3H3,(H,34,40)	WWHYYLLELVGLKH-UHFFFAOYSA-N	794562	US20260062387, Example 93	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794562&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606016	528826025							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125983	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H24F4N6O4/c1-13(38)11-37-12-17(10-33-37)14-4-16(9-32)22-18(5-14)35-36(2)24(22)15-6-19(40-3)23(20(7-15)41-26(28)29)25(39)34-21-8-27(21,30)31/h4-7,10,12-13,21,26,38H,8,11H2,1-3H3,(H,34,39)	ZDUOHIZFTKAUFZ-UHFFFAOYSA-N	794563	US20260062387, Example 94	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794563&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606091	528826026							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125984	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H24F4N6O4/c1-13(38)11-37-12-17(10-33-37)14-4-16(9-32)22-18(5-14)35-36(2)24(22)15-6-19(40-3)23(20(7-15)41-26(28)29)25(39)34-21-8-27(21,30)31/h4-7,10,12-13,21,26,38H,8,11H2,1-3H3,(H,34,39)	ZDUOHIZFTKAUFZ-UHFFFAOYSA-N	794563	US20260062387, Example 94	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794563&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606091	528826026							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125985	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H24F4N6O4/c1-13(38)11-37-12-17(10-33-37)14-4-16(9-32)22-18(5-14)35-36(2)24(22)15-6-19(40-3)23(20(7-15)41-26(28)29)25(39)34-21-8-27(21,30)31/h4-7,10,12-13,21,26,38H,8,11H2,1-3H3,(H,34,39)	ZDUOHIZFTKAUFZ-UHFFFAOYSA-N	794563	US20260062387, Example 94	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794563&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606091	528826026							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125986	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C28H26F4N6O4/c1-14(39)12-38-13-18(10-35-38)15-4-17(9-33)23-20(5-15)36-37(2)25(23)16-6-21(41-3)24(22(7-16)42-27(29)30)26(40)34-11-19-8-28(19,31)32/h4-7,10,13-14,19,27,39H,8,11-12H2,1-3H3,(H,34,40)	JRXYANBJQMNLGB-UHFFFAOYSA-N	794564	US20260062387, Example 95	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794564&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			178423161	528826027							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125987	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C28H26F4N6O4/c1-14(39)12-38-13-18(10-35-38)15-4-17(9-33)23-20(5-15)36-37(2)25(23)16-6-21(41-3)24(22(7-16)42-27(29)30)26(40)34-11-19-8-28(19,31)32/h4-7,10,13-14,19,27,39H,8,11-12H2,1-3H3,(H,34,40)	JRXYANBJQMNLGB-UHFFFAOYSA-N	794564	US20260062387, Example 95	Serine/threonine-protein kinase SIK2	Homo sapiens		 13.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794564&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			178423161	528826027							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125988	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C28H26F4N6O4/c1-14(39)12-38-13-18(10-35-38)15-4-17(9-33)23-20(5-15)36-37(2)25(23)16-6-21(41-3)24(22(7-16)42-27(29)30)26(40)34-11-19-8-28(19,31)32/h4-7,10,13-14,19,27,39H,8,11-12H2,1-3H3,(H,34,40)	JRXYANBJQMNLGB-UHFFFAOYSA-N	794564	US20260062387, Example 95	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794564&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			178423161	528826027							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125989	CCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H22F2N6O3/c1-4-5-32-12-16(11-29-32)13-6-15(10-27)20-17(7-13)30-31(2)22(20)14-8-18(34-3)21(23(28)33)19(9-14)35-24(25)26/h6-9,11-12,24H,4-5H2,1-3H3,(H2,28,33)	IVGXQQRUGCWLHO-UHFFFAOYSA-N	794565	US20260062387, Example 96	Serine/threonine-protein kinase SIK1	Homo sapiens		 14.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794565&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606129	528826028							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125990	CCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H22F2N6O3/c1-4-5-32-12-16(11-29-32)13-6-15(10-27)20-17(7-13)30-31(2)22(20)14-8-18(34-3)21(23(28)33)19(9-14)35-24(25)26/h6-9,11-12,24H,4-5H2,1-3H3,(H2,28,33)	IVGXQQRUGCWLHO-UHFFFAOYSA-N	794565	US20260062387, Example 96	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794565&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606129	528826028							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125991	CCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H22F2N6O3/c1-4-5-32-12-16(11-29-32)13-6-15(10-27)20-17(7-13)30-31(2)22(20)14-8-18(34-3)21(23(28)33)19(9-14)35-24(25)26/h6-9,11-12,24H,4-5H2,1-3H3,(H2,28,33)	IVGXQQRUGCWLHO-UHFFFAOYSA-N	794565	US20260062387, Example 96	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794565&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606129	528826028							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125992	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@@H](O)c5ccccc5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C33H29F3N6O4/c1-41-30(21-12-26(45-2)29(27(13-21)46-32(34)35)31(44)38-18-33(36)8-9-33)28-22(14-37)10-20(11-24(28)40-41)23-15-39-42(16-23)17-25(43)19-6-4-3-5-7-19/h3-7,10-13,15-16,25,32,43H,8-9,17-18H2,1-2H3,(H,38,44)	MVBCLPFADFMSKQ-UHFFFAOYSA-N	794566	US20260062387, Example 97	Serine/threonine-protein kinase SIK1	Homo sapiens		 15.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794566&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606148	528826029							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125993	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@@H](O)c5ccccc5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C33H29F3N6O4/c1-41-30(21-12-26(45-2)29(27(13-21)46-32(34)35)31(44)38-18-33(36)8-9-33)28-22(14-37)10-20(11-24(28)40-41)23-15-39-42(16-23)17-25(43)19-6-4-3-5-7-19/h3-7,10-13,15-16,25,32,43H,8-9,17-18H2,1-2H3,(H,38,44)	MVBCLPFADFMSKQ-UHFFFAOYSA-N	794566	US20260062387, Example 97	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794566&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606148	528826029							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125994	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@@H](O)c5ccccc5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C33H29F3N6O4/c1-41-30(21-12-26(45-2)29(27(13-21)46-32(34)35)31(44)38-18-33(36)8-9-33)28-22(14-37)10-20(11-24(28)40-41)23-15-39-42(16-23)17-25(43)19-6-4-3-5-7-19/h3-7,10-13,15-16,25,32,43H,8-9,17-18H2,1-2H3,(H,38,44)	MVBCLPFADFMSKQ-UHFFFAOYSA-N	794566	US20260062387, Example 97	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794566&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606148	528826029							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125995	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H28F3N7O4/c1-37(2)23(40)14-39-13-19(12-35-39)16-7-18(11-33)24-20(8-16)36-38(3)26(24)17-9-21(42-4)25(22(10-17)43-28(30)31)27(41)34-15-29(32)5-6-29/h7-10,12-13,28H,5-6,14-15H2,1-4H3,(H,34,41)	YSHMGYMPBFDBAK-UHFFFAOYSA-N	794567	US20260062387, Example 98	Serine/threonine-protein kinase SIK1	Homo sapiens		 17.9							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794567&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606013	528826030							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125996	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H28F3N7O4/c1-37(2)23(40)14-39-13-19(12-35-39)16-7-18(11-33)24-20(8-16)36-38(3)26(24)17-9-21(42-4)25(22(10-17)43-28(30)31)27(41)34-15-29(32)5-6-29/h7-10,12-13,28H,5-6,14-15H2,1-4H3,(H,34,41)	YSHMGYMPBFDBAK-UHFFFAOYSA-N	794567	US20260062387, Example 98	Serine/threonine-protein kinase SIK2	Homo sapiens		 10.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794567&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606013	528826030							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125997	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C29H28F3N7O4/c1-37(2)23(40)14-39-13-19(12-35-39)16-7-18(11-33)24-20(8-16)36-38(3)26(24)17-9-21(42-4)25(22(10-17)43-28(30)31)27(41)34-15-29(32)5-6-29/h7-10,12-13,28H,5-6,14-15H2,1-4H3,(H,34,41)	YSHMGYMPBFDBAK-UHFFFAOYSA-N	794567	US20260062387, Example 98	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794567&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606013	528826030							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125998	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N5CC(F)(F)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H26F5N7O4/c1-40-26(17-7-21(45-2)25(22(8-17)46-28(31)32)27(44)37-13-29(33)3-4-29)24-18(9-36)5-16(6-20(24)39-40)19-10-38-42(11-19)12-23(43)41-14-30(34,35)15-41/h5-8,10-11,28H,3-4,12-15H2,1-2H3,(H,37,44)	QNOOHUCQSOVIMH-UHFFFAOYSA-N	794568	US20260062387, Example 99	Serine/threonine-protein kinase SIK1	Homo sapiens		 19.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794568&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606085	528826031							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125999	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N5CC(F)(F)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H26F5N7O4/c1-40-26(17-7-21(45-2)25(22(8-17)46-28(31)32)27(44)37-13-29(33)3-4-29)24-18(9-36)5-16(6-20(24)39-40)19-10-38-42(11-19)12-23(43)41-14-30(34,35)15-41/h5-8,10-11,28H,3-4,12-15H2,1-2H3,(H,37,44)	QNOOHUCQSOVIMH-UHFFFAOYSA-N	794568	US20260062387, Example 99	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794568&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606085	528826031							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126000	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N5CC(F)(F)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C30H26F5N7O4/c1-40-26(17-7-21(45-2)25(22(8-17)46-28(31)32)27(44)37-13-29(33)3-4-29)24-18(9-36)5-16(6-20(24)39-40)19-10-38-42(11-19)12-23(43)41-14-30(34,35)15-41/h5-8,10-11,28H,3-4,12-15H2,1-2H3,(H,37,44)	QNOOHUCQSOVIMH-UHFFFAOYSA-N	794568	US20260062387, Example 99	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794568&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606085	528826031							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126001	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N5CCCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C31H30F3N7O4/c1-39-28(19-11-23(44-2)27(24(12-19)45-30(32)33)29(43)36-17-31(34)5-6-31)26-20(13-35)9-18(10-22(26)38-39)21-14-37-41(15-21)16-25(42)40-7-3-4-8-40/h9-12,14-15,30H,3-8,16-17H2,1-2H3,(H,36,43)	SJDHDPRRGUNVSC-UHFFFAOYSA-N	794569	US20260062387, Example 100	Serine/threonine-protein kinase SIK1	Homo sapiens		 15.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794569&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605986	528826032							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126002	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N5CCCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C31H30F3N7O4/c1-39-28(19-11-23(44-2)27(24(12-19)45-30(32)33)29(43)36-17-31(34)5-6-31)26-20(13-35)9-18(10-22(26)38-39)21-14-37-41(15-21)16-25(42)40-7-3-4-8-40/h9-12,14-15,30H,3-8,16-17H2,1-2H3,(H,36,43)	SJDHDPRRGUNVSC-UHFFFAOYSA-N	794569	US20260062387, Example 100	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794569&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605986	528826032							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126003	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N5CCCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C31H30F3N7O4/c1-39-28(19-11-23(44-2)27(24(12-19)45-30(32)33)29(43)36-17-31(34)5-6-31)26-20(13-35)9-18(10-22(26)38-39)21-14-37-41(15-21)16-25(42)40-7-3-4-8-40/h9-12,14-15,30H,3-8,16-17H2,1-2H3,(H,36,43)	SJDHDPRRGUNVSC-UHFFFAOYSA-N	794569	US20260062387, Example 100	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794569&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605986	528826032							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126004	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N5CCC(F)(F)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C31H28F5N7O4/c1-41-27(18-9-22(46-2)26(23(10-18)47-29(32)33)28(45)38-15-30(34)3-4-30)25-19(11-37)7-17(8-21(25)40-41)20-12-39-43(13-20)14-24(44)42-6-5-31(35,36)16-42/h7-10,12-13,29H,3-6,14-16H2,1-2H3,(H,38,45)	GIPRBMVSENSNTM-UHFFFAOYSA-N	794570	US20260062387, Example 101	Serine/threonine-protein kinase SIK1	Homo sapiens		 15.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794570&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606103	528826033							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126005	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N5CCC(F)(F)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C31H28F5N7O4/c1-41-27(18-9-22(46-2)26(23(10-18)47-29(32)33)28(45)38-15-30(34)3-4-30)25-19(11-37)7-17(8-21(25)40-41)20-12-39-43(13-20)14-24(44)42-6-5-31(35,36)16-42/h7-10,12-13,29H,3-6,14-16H2,1-2H3,(H,38,45)	GIPRBMVSENSNTM-UHFFFAOYSA-N	794570	US20260062387, Example 101	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794570&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606103	528826033							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126006	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(=O)N5CCC(F)(F)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C31H28F5N7O4/c1-41-27(18-9-22(46-2)26(23(10-18)47-29(32)33)28(45)38-15-30(34)3-4-30)25-19(11-37)7-17(8-21(25)40-41)20-12-39-43(13-20)14-24(44)42-6-5-31(35,36)16-42/h7-10,12-13,29H,3-6,14-16H2,1-2H3,(H,38,45)	GIPRBMVSENSNTM-UHFFFAOYSA-N	794570	US20260062387, Example 101	Serine/threonine-protein kinase SIK3	Homo sapiens		 12.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794570&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606103	528826033							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126007	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H18F4N6O3/c1-32-21(12-5-16(35-2)20(22(29)34)17(6-12)36-23(26)27)19-13(7-28)3-11(4-15(19)31-32)14-8-30-33(9-14)10-18(24)25/h3-6,8-9,18,23H,10H2,1-2H3,(H2,29,34)	RUSXMXLVLRGEPP-UHFFFAOYSA-N	794571	US20260062387, Example 102	Serine/threonine-protein kinase SIK1	Homo sapiens		 19.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794571&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606219	528826034							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126008	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H18F4N6O3/c1-32-21(12-5-16(35-2)20(22(29)34)17(6-12)36-23(26)27)19-13(7-28)3-11(4-15(19)31-32)14-8-30-33(9-14)10-18(24)25/h3-6,8-9,18,23H,10H2,1-2H3,(H2,29,34)	RUSXMXLVLRGEPP-UHFFFAOYSA-N	794571	US20260062387, Example 102	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794571&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606219	528826034							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126009	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H18F4N6O3/c1-32-21(12-5-16(35-2)20(22(29)34)17(6-12)36-23(26)27)19-13(7-28)3-11(4-15(19)31-32)14-8-30-33(9-14)10-18(24)25/h3-6,8-9,18,23H,10H2,1-2H3,(H2,29,34)	RUSXMXLVLRGEPP-UHFFFAOYSA-N	794571	US20260062387, Example 102	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794571&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606219	528826034							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126010	COc1cc(-c2c3c(OCc4cncc(F)c4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C31H26F6N6O5/c1-41-12-19(10-39-41)17-5-21-25(23(6-17)47-13-16-4-20(32)11-38-9-16)27(42(2)40-21)18-7-22(46-3)26(24(8-18)48-29(33)34)28(44)43-14-30(45,15-43)31(35,36)37/h4-12,29,45H,13-15H2,1-3H3	JRTMLGSSWZDALA-UHFFFAOYSA-N	794572	US20260062387, Example 103	Serine/threonine-protein kinase SIK1	Homo sapiens		 4.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794572&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605950	528826035							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126011	COc1cc(-c2c3c(OCc4cncc(F)c4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C31H26F6N6O5/c1-41-12-19(10-39-41)17-5-21-25(23(6-17)47-13-16-4-20(32)11-38-9-16)27(42(2)40-21)18-7-22(46-3)26(24(8-18)48-29(33)34)28(44)43-14-30(45,15-43)31(35,36)37/h4-12,29,45H,13-15H2,1-3H3	JRTMLGSSWZDALA-UHFFFAOYSA-N	794572	US20260062387, Example 103	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794572&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605950	528826035							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126012	COc1cc(-c2c3c(OCc4cncc(F)c4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C31H26F6N6O5/c1-41-12-19(10-39-41)17-5-21-25(23(6-17)47-13-16-4-20(32)11-38-9-16)27(42(2)40-21)18-7-22(46-3)26(24(8-18)48-29(33)34)28(44)43-14-30(45,15-43)31(35,36)37/h4-12,29,45H,13-15H2,1-3H3	JRTMLGSSWZDALA-UHFFFAOYSA-N	794572	US20260062387, Example 103	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794572&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605950	528826035							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126013	COc1cc(-c2c3c(OCc4cncc(C#N)c4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C32H26F5N7O5/c1-42-13-21(12-40-42)19-5-22-26(24(6-19)48-14-18-4-17(9-38)10-39-11-18)28(43(2)41-22)20-7-23(47-3)27(25(8-20)49-30(33)34)29(45)44-15-31(46,16-44)32(35,36)37/h4-8,10-13,30,46H,14-16H2,1-3H3	NGHOUEOVRBKDIY-UHFFFAOYSA-N	794573	US20260062387, Example 104	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794573&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606112	528826036							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126014	COc1cc(-c2c3c(OCc4cncc(C#N)c4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C32H26F5N7O5/c1-42-13-21(12-40-42)19-5-22-26(24(6-19)48-14-18-4-17(9-38)10-39-11-18)28(43(2)41-22)20-7-23(47-3)27(25(8-20)49-30(33)34)29(45)44-15-31(46,16-44)32(35,36)37/h4-8,10-13,30,46H,14-16H2,1-3H3	NGHOUEOVRBKDIY-UHFFFAOYSA-N	794573	US20260062387, Example 104	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794573&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606112	528826036							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126015	COc1cc(-c2c3c(OCc4cncc(C#N)c4)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N1CC(O)(C(F)(F)F)C1	InChI=1S/C32H26F5N7O5/c1-42-13-21(12-40-42)19-5-22-26(24(6-19)48-14-18-4-17(9-38)10-39-11-18)28(43(2)41-22)20-7-23(47-3)27(25(8-20)49-30(33)34)29(45)44-15-31(46,16-44)32(35,36)37/h4-8,10-13,30,46H,14-16H2,1-3H3	NGHOUEOVRBKDIY-UHFFFAOYSA-N	794573	US20260062387, Example 104	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794573&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606112	528826036							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126016	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H24N6O2/c1-5-31-13-18(12-28-31)15-6-17(10-26)22-20(8-15)29-30(3)24(22)16-7-19-14(2)11-27-25(32)23(19)21(9-16)33-4/h6-9,12-14H,5,11H2,1-4H3,(H,27,32)	ZWFXEQGRPLSFSM-UHFFFAOYSA-N	794574	US20260062387, Example 105	Serine/threonine-protein kinase SIK1	Homo sapiens		 10.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794574&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606165	528826037							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126017	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H24N6O2/c1-5-31-13-18(12-28-31)15-6-17(10-26)22-20(8-15)29-30(3)24(22)16-7-19-14(2)11-27-25(32)23(19)21(9-16)33-4/h6-9,12-14H,5,11H2,1-4H3,(H,27,32)	ZWFXEQGRPLSFSM-UHFFFAOYSA-N	794574	US20260062387, Example 105	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794574&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606165	528826037							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126018	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H24N6O2/c1-5-31-13-18(12-28-31)15-6-17(10-26)22-20(8-15)29-30(3)24(22)16-7-19-14(2)11-27-25(32)23(19)21(9-16)33-4/h6-9,12-14H,5,11H2,1-4H3,(H,27,32)	ZWFXEQGRPLSFSM-UHFFFAOYSA-N	794574	US20260062387, Example 105	Serine/threonine-protein kinase SIK3	Homo sapiens		 8.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794574&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606165	528826037							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126019	CCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H26N6O2/c1-5-6-32-14-19(13-29-32)16-7-18(11-27)23-21(9-16)30-31(3)25(23)17-8-20-15(2)12-28-26(33)24(20)22(10-17)34-4/h7-10,13-15H,5-6,12H2,1-4H3,(H,28,33)	XKYOLJNQBFQQKD-UHFFFAOYSA-N	794575	US20260062387, Example 106	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794575&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606054	528826038							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126020	CCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H26N6O2/c1-5-6-32-14-19(13-29-32)16-7-18(11-27)23-21(9-16)30-31(3)25(23)17-8-20-15(2)12-28-26(33)24(20)22(10-17)34-4/h7-10,13-15H,5-6,12H2,1-4H3,(H,28,33)	XKYOLJNQBFQQKD-UHFFFAOYSA-N	794575	US20260062387, Example 106	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794575&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606054	528826038							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126021	CCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H26N6O2/c1-5-6-32-14-19(13-29-32)16-7-18(11-27)23-21(9-16)30-31(3)25(23)17-8-20-15(2)12-28-26(33)24(20)22(10-17)34-4/h7-10,13-15H,5-6,12H2,1-4H3,(H,28,33)	XKYOLJNQBFQQKD-UHFFFAOYSA-N	794575	US20260062387, Example 106	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794575&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606054	528826038							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126022	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C25H22F2N6O2/c1-13-9-29-25(34)23-18(13)5-15(7-20(23)35-3)24-22-16(8-28)4-14(6-19(22)31-32(24)2)17-10-30-33(11-17)12-21(26)27/h4-7,10-11,13,21H,9,12H2,1-3H3,(H,29,34)	JDKRPFJABRGLDD-UHFFFAOYSA-N	794576	US20260062387, Example 107	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794576&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606044	528826039							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126023	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C25H22F2N6O2/c1-13-9-29-25(34)23-18(13)5-15(7-20(23)35-3)24-22-16(8-28)4-14(6-19(22)31-32(24)2)17-10-30-33(11-17)12-21(26)27/h4-7,10-11,13,21H,9,12H2,1-3H3,(H,29,34)	JDKRPFJABRGLDD-UHFFFAOYSA-N	794576	US20260062387, Example 107	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794576&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606044	528826039							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126024	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C25H22F2N6O2/c1-13-9-29-25(34)23-18(13)5-15(7-20(23)35-3)24-22-16(8-28)4-14(6-19(22)31-32(24)2)17-10-30-33(11-17)12-21(26)27/h4-7,10-11,13,21H,9,12H2,1-3H3,(H,29,34)	JDKRPFJABRGLDD-UHFFFAOYSA-N	794576	US20260062387, Example 107	Serine/threonine-protein kinase SIK3	Homo sapiens		 8.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794576&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606044	528826039							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126025	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCN5CC(F)(F)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C30H27F6N7O3/c1-41-26(17-7-22(45-2)25(23(8-17)46-28(31)32)27(44)38-12-20-9-30(20,35)36)24-18(10-37)5-16(6-21(24)40-41)19-11-39-43(13-19)4-3-42-14-29(33,34)15-42/h5-8,11,13,20,28H,3-4,9,12,14-15H2,1-2H3,(H,38,44)	BGXOUUDGXDKDJB-UHFFFAOYSA-N	794577	US20260062387, Example 108	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794577&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			178423162	528826040							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126026	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCN5CC(F)(F)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C30H27F6N7O3/c1-41-26(17-7-22(45-2)25(23(8-17)46-28(31)32)27(44)38-12-20-9-30(20,35)36)24-18(10-37)5-16(6-21(24)40-41)19-11-39-43(13-19)4-3-42-14-29(33,34)15-42/h5-8,11,13,20,28H,3-4,9,12,14-15H2,1-2H3,(H,38,44)	BGXOUUDGXDKDJB-UHFFFAOYSA-N	794577	US20260062387, Example 108	Serine/threonine-protein kinase SIK2	Homo sapiens		 6.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794577&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			178423162	528826040							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126027	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCN5CC(F)(F)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NC[C@@H]1CC1(F)F	InChI=1S/C30H27F6N7O3/c1-41-26(17-7-22(45-2)25(23(8-17)46-28(31)32)27(44)38-12-20-9-30(20,35)36)24-18(10-37)5-16(6-21(24)40-41)19-11-39-43(13-19)4-3-42-14-29(33,34)15-42/h5-8,11,13,20,28H,3-4,9,12,14-15H2,1-2H3,(H,38,44)	BGXOUUDGXDKDJB-UHFFFAOYSA-N	794577	US20260062387, Example 108	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794577&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			178423162	528826040							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126028	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C28H27F6N5O4/c1-27(2,41)12-39-11-15(10-35-39)13-5-16(24(29)30)21-17(6-13)37-38(3)23(21)14-7-18(42-4)22(19(8-14)43-26(31)32)25(40)36-20-9-28(20,33)34/h5-8,10-11,20,24,26,41H,9,12H2,1-4H3,(H,36,40)	WYJJXZJGCROEDG-UHFFFAOYSA-N	794578	US20260062387, Example 109	Serine/threonine-protein kinase SIK1	Homo sapiens		 18.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794578&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606227	528826041							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126029	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C28H27F6N5O4/c1-27(2,41)12-39-11-15(10-35-39)13-5-16(24(29)30)21-17(6-13)37-38(3)23(21)14-7-18(42-4)22(19(8-14)43-26(31)32)25(40)36-20-9-28(20,33)34/h5-8,10-11,20,24,26,41H,9,12H2,1-4H3,(H,36,40)	WYJJXZJGCROEDG-UHFFFAOYSA-N	794578	US20260062387, Example 109	Serine/threonine-protein kinase SIK2	Homo sapiens		 18.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794578&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606227	528826041							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126030	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C28H27F6N5O4/c1-27(2,41)12-39-11-15(10-35-39)13-5-16(24(29)30)21-17(6-13)37-38(3)23(21)14-7-18(42-4)22(19(8-14)43-26(31)32)25(40)36-20-9-28(20,33)34/h5-8,10-11,20,24,26,41H,9,12H2,1-4H3,(H,36,40)	WYJJXZJGCROEDG-UHFFFAOYSA-N	794578	US20260062387, Example 109	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794578&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606227	528826041							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126031	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H26F4N6O4/c1-38-25(16-8-20(42-2)24(21(9-16)43-27(30)31)26(40)36-22-10-29(22,32)33)23-17(11-34)6-15(7-19(23)37-38)18-12-35-39(13-18)14-28(41)4-3-5-28/h6-9,12-13,22,27,41H,3-5,10,14H2,1-2H3,(H,36,40)	IPRIDYVSHTUVMI-UHFFFAOYSA-N	794579	US20260062387, Example 110	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794579&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606029	528826042							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126032	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H26F4N6O4/c1-38-25(16-8-20(42-2)24(21(9-16)43-27(30)31)26(40)36-22-10-29(22,32)33)23-17(11-34)6-15(7-19(23)37-38)18-12-35-39(13-18)14-28(41)4-3-5-28/h6-9,12-13,22,27,41H,3-5,10,14H2,1-2H3,(H,36,40)	IPRIDYVSHTUVMI-UHFFFAOYSA-N	794579	US20260062387, Example 110	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794579&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606029	528826042							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126033	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H26F4N6O4/c1-38-25(16-8-20(42-2)24(21(9-16)43-27(30)31)26(40)36-22-10-29(22,32)33)23-17(11-34)6-15(7-19(23)37-38)18-12-35-39(13-18)14-28(41)4-3-5-28/h6-9,12-13,22,27,41H,3-5,10,14H2,1-2H3,(H,36,40)	IPRIDYVSHTUVMI-UHFFFAOYSA-N	794579	US20260062387, Example 110	Serine/threonine-protein kinase SIK3	Homo sapiens		 1.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794579&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606029	528826042							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126034	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H28F4N6O4/c1-28(2,41)5-6-39-14-18(13-35-39)15-7-17(12-34)23-19(8-15)37-38(3)25(23)16-9-20(42-4)24(21(10-16)43-27(30)31)26(40)36-22-11-29(22,32)33/h7-10,13-14,22,27,41H,5-6,11H2,1-4H3,(H,36,40)	FPWOJFOLLDGMOB-UHFFFAOYSA-N	794580	US20260062387, Example 111	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794580&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605928	528826043							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126035	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H28F4N6O4/c1-28(2,41)5-6-39-14-18(13-35-39)15-7-17(12-34)23-19(8-15)37-38(3)25(23)16-9-20(42-4)24(21(10-16)43-27(30)31)26(40)36-22-11-29(22,32)33/h7-10,13-14,22,27,41H,5-6,11H2,1-4H3,(H,36,40)	FPWOJFOLLDGMOB-UHFFFAOYSA-N	794580	US20260062387, Example 111	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794580&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605928	528826043							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126036	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H28F4N6O4/c1-28(2,41)5-6-39-14-18(13-35-39)15-7-17(12-34)23-19(8-15)37-38(3)25(23)16-9-20(42-4)24(21(10-16)43-27(30)31)26(40)36-22-11-29(22,32)33/h7-10,13-14,22,27,41H,5-6,11H2,1-4H3,(H,36,40)	FPWOJFOLLDGMOB-UHFFFAOYSA-N	794580	US20260062387, Example 111	Serine/threonine-protein kinase SIK3	Homo sapiens		 1.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794580&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605928	528826043							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126037	CCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C23H21F4N5O3/c1-4-32-10-13(9-29-32)11-5-14(21(24)25)18-15(6-11)30-31(2)20(18)12-7-16(34-3)19(22(28)33)17(8-12)35-23(26)27/h5-10,21,23H,4H2,1-3H3,(H2,28,33)	MSLSGYNVCHXGKL-UHFFFAOYSA-N	794581	US20260062387, Example 112	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794581&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606037	528826044							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126038	CCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C23H21F4N5O3/c1-4-32-10-13(9-29-32)11-5-14(21(24)25)18-15(6-11)30-31(2)20(18)12-7-16(34-3)19(22(28)33)17(8-12)35-23(26)27/h5-10,21,23H,4H2,1-3H3,(H2,28,33)	MSLSGYNVCHXGKL-UHFFFAOYSA-N	794581	US20260062387, Example 112	Serine/threonine-protein kinase SIK2	Homo sapiens		 13.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794581&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606037	528826044							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126039	CCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C23H21F4N5O3/c1-4-32-10-13(9-29-32)11-5-14(21(24)25)18-15(6-11)30-31(2)20(18)12-7-16(34-3)19(22(28)33)17(8-12)35-23(26)27/h5-10,21,23H,4H2,1-3H3,(H2,28,33)	MSLSGYNVCHXGKL-UHFFFAOYSA-N	794581	US20260062387, Example 112	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794581&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606037	528826044							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126040	CCCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H23F4N5O3/c1-4-5-33-11-14(10-30-33)12-6-15(22(25)26)19-16(7-12)31-32(2)21(19)13-8-17(35-3)20(23(29)34)18(9-13)36-24(27)28/h6-11,22,24H,4-5H2,1-3H3,(H2,29,34)	RLFJGMBLJMGTIJ-UHFFFAOYSA-N	794582	US20260062387, Example 113	Serine/threonine-protein kinase SIK1	Homo sapiens		 19.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794582&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605929	528826045							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126041	CCCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H23F4N5O3/c1-4-5-33-11-14(10-30-33)12-6-15(22(25)26)19-16(7-12)31-32(2)21(19)13-8-17(35-3)20(23(29)34)18(9-13)36-24(27)28/h6-11,22,24H,4-5H2,1-3H3,(H2,29,34)	RLFJGMBLJMGTIJ-UHFFFAOYSA-N	794582	US20260062387, Example 113	Serine/threonine-protein kinase SIK2	Homo sapiens		 15.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794582&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605929	528826045							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126042	CCCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H23F4N5O3/c1-4-5-33-11-14(10-30-33)12-6-15(22(25)26)19-16(7-12)31-32(2)21(19)13-8-17(35-3)20(23(29)34)18(9-13)36-24(27)28/h6-11,22,24H,4-5H2,1-3H3,(H2,29,34)	RLFJGMBLJMGTIJ-UHFFFAOYSA-N	794582	US20260062387, Example 113	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794582&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605929	528826045							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126043	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C28H26F4N6O4/c1-27(2,40)13-38-12-17(11-34-38)14-5-16(10-33)22-18(6-14)36-37(3)24(22)15-7-19(41-4)23(20(8-15)42-26(29)30)25(39)35-21-9-28(21,31)32/h5-8,11-12,21,26,40H,9,13H2,1-4H3,(H,35,39)	QPTMQKZBXZNHGS-UHFFFAOYSA-N	794583	US20260062387, Example 114	Serine/threonine-protein kinase SIK1	Homo sapiens		 12.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794583&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605944	528826046							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126044	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C28H26F4N6O4/c1-27(2,40)13-38-12-17(11-34-38)14-5-16(10-33)22-18(6-14)36-37(3)24(22)15-7-19(41-4)23(20(8-15)42-26(29)30)25(39)35-21-9-28(21,31)32/h5-8,11-12,21,26,40H,9,13H2,1-4H3,(H,35,39)	QPTMQKZBXZNHGS-UHFFFAOYSA-N	794583	US20260062387, Example 114	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794583&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605944	528826046							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126045	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C28H26F4N6O4/c1-27(2,40)13-38-12-17(11-34-38)14-5-16(10-33)22-18(6-14)36-37(3)24(22)15-7-19(41-4)23(20(8-15)42-26(29)30)25(39)35-21-9-28(21,31)32/h5-8,11-12,21,26,40H,9,13H2,1-4H3,(H,35,39)	QPTMQKZBXZNHGS-UHFFFAOYSA-N	794583	US20260062387, Example 114	Serine/threonine-protein kinase SIK3	Homo sapiens		 0.700							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794583&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605944	528826046							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126046	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C26H20F6N6O3/c1-37-23(21-14(8-33)3-12(4-16(21)36-37)15-9-34-38(10-15)11-20(27)28)13-5-17(40-2)22(18(6-13)41-25(29)30)24(39)35-19-7-26(19,31)32/h3-6,9-10,19-20,25H,7,11H2,1-2H3,(H,35,39)	DVYVZXGHBOKOHL-UHFFFAOYSA-N	794584	US20260062387, Example 115	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794584&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606210	528826047							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126047	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C26H20F6N6O3/c1-37-23(21-14(8-33)3-12(4-16(21)36-37)15-9-34-38(10-15)11-20(27)28)13-5-17(40-2)22(18(6-13)41-25(29)30)24(39)35-19-7-26(19,31)32/h3-6,9-10,19-20,25H,7,11H2,1-2H3,(H,35,39)	DVYVZXGHBOKOHL-UHFFFAOYSA-N	794584	US20260062387, Example 115	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794584&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606210	528826047							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126048	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C26H20F6N6O3/c1-37-23(21-14(8-33)3-12(4-16(21)36-37)15-9-34-38(10-15)11-20(27)28)13-5-17(40-2)22(18(6-13)41-25(29)30)24(39)35-19-7-26(19,31)32/h3-6,9-10,19-20,25H,7,11H2,1-2H3,(H,35,39)	DVYVZXGHBOKOHL-UHFFFAOYSA-N	794584	US20260062387, Example 115	Serine/threonine-protein kinase SIK3	Homo sapiens		<0.600							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794584&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606210	528826047							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126049	CCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(=O)N[C@@H]5CC5(F)F)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C26H23F6N5O3/c1-4-37-11-14(10-33-37)12-5-15(23(27)28)20-16(6-12)35-36(2)22(20)13-7-17(39-3)21(18(8-13)40-25(29)30)24(38)34-19-9-26(19,31)32/h5-8,10-11,19,23,25H,4,9H2,1-3H3,(H,34,38)	MQIAUQKXOBWXOV-UHFFFAOYSA-N	794585	US20260062387, Example 116	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794585&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606113	528826048							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126050	CCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(=O)N[C@@H]5CC5(F)F)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C26H23F6N5O3/c1-4-37-11-14(10-33-37)12-5-15(23(27)28)20-16(6-12)35-36(2)22(20)13-7-17(39-3)21(18(8-13)40-25(29)30)24(38)34-19-9-26(19,31)32/h5-8,10-11,19,23,25H,4,9H2,1-3H3,(H,34,38)	MQIAUQKXOBWXOV-UHFFFAOYSA-N	794585	US20260062387, Example 116	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794585&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606113	528826048							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126051	CCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(=O)N[C@@H]5CC5(F)F)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C26H23F6N5O3/c1-4-37-11-14(10-33-37)12-5-15(23(27)28)20-16(6-12)35-36(2)22(20)13-7-17(39-3)21(18(8-13)40-25(29)30)24(38)34-19-9-26(19,31)32/h5-8,10-11,19,23,25H,4,9H2,1-3H3,(H,34,38)	MQIAUQKXOBWXOV-UHFFFAOYSA-N	794585	US20260062387, Example 116	Serine/threonine-protein kinase SIK3	Homo sapiens		 1.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794585&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606113	528826048							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126052	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H27F6N5O4/c1-39-24(15-8-19(43-2)23(20(9-15)44-27(32)33)26(41)37-21-10-29(21,34)35)22-17(25(30)31)6-14(7-18(22)38-39)16-11-36-40(12-16)13-28(42)4-3-5-28/h6-9,11-12,21,25,27,42H,3-5,10,13H2,1-2H3,(H,37,41)	ZJIFBGNHVPQFCB-UHFFFAOYSA-N	794586	US20260062387, Example 117	Serine/threonine-protein kinase SIK1	Homo sapiens		 12.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794586&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605933	528826049							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126053	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H27F6N5O4/c1-39-24(15-8-19(43-2)23(20(9-15)44-27(32)33)26(41)37-21-10-29(21,34)35)22-17(25(30)31)6-14(7-18(22)38-39)16-11-36-40(12-16)13-28(42)4-3-5-28/h6-9,11-12,21,25,27,42H,3-5,10,13H2,1-2H3,(H,37,41)	ZJIFBGNHVPQFCB-UHFFFAOYSA-N	794586	US20260062387, Example 117	Serine/threonine-protein kinase SIK2	Homo sapiens		 9.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794586&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605933	528826049							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126054	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H27F6N5O4/c1-39-24(15-8-19(43-2)23(20(9-15)44-27(32)33)26(41)37-21-10-29(21,34)35)22-17(25(30)31)6-14(7-18(22)38-39)16-11-36-40(12-16)13-28(42)4-3-5-28/h6-9,11-12,21,25,27,42H,3-5,10,13H2,1-2H3,(H,37,41)	ZJIFBGNHVPQFCB-UHFFFAOYSA-N	794586	US20260062387, Example 117	Serine/threonine-protein kinase SIK3	Homo sapiens		 1.000							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794586&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605933	528826049							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126055	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(=O)N[C@@H]5CC5(F)F)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C26H22F4N6O3/c1-4-36-12-16(11-32-36)13-5-15(10-31)21-17(6-13)34-35(2)23(21)14-7-18(38-3)22(19(8-14)39-25(27)28)24(37)33-20-9-26(20,29)30/h5-8,11-12,20,25H,4,9H2,1-3H3,(H,33,37)	DPNSLKOPHRUQOW-UHFFFAOYSA-N	794587	US20260062387, Example 118	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794587&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606157	528826050							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126056	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(=O)N[C@@H]5CC5(F)F)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C26H22F4N6O3/c1-4-36-12-16(11-32-36)13-5-15(10-31)21-17(6-13)34-35(2)23(21)14-7-18(38-3)22(19(8-14)39-25(27)28)24(37)33-20-9-26(20,29)30/h5-8,11-12,20,25H,4,9H2,1-3H3,(H,33,37)	DPNSLKOPHRUQOW-UHFFFAOYSA-N	794587	US20260062387, Example 118	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.000							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794587&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606157	528826050							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126057	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(=O)N[C@@H]5CC5(F)F)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C26H22F4N6O3/c1-4-36-12-16(11-32-36)13-5-15(10-31)21-17(6-13)34-35(2)23(21)14-7-18(38-3)22(19(8-14)39-25(27)28)24(37)33-20-9-26(20,29)30/h5-8,11-12,20,25H,4,9H2,1-3H3,(H,33,37)	DPNSLKOPHRUQOW-UHFFFAOYSA-N	794587	US20260062387, Example 118	Serine/threonine-protein kinase SIK3	Homo sapiens		 0.600							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794587&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606157	528826050							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126058	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H29F6N5O4/c1-28(2,42)5-6-40-13-16(12-36-40)14-7-17(25(30)31)22-18(8-14)38-39(3)24(22)15-9-19(43-4)23(20(10-15)44-27(32)33)26(41)37-21-11-29(21,34)35/h7-10,12-13,21,25,27,42H,5-6,11H2,1-4H3,(H,37,41)	ANJQPCHJDZARNJ-UHFFFAOYSA-N	794588	US20260062387, Example 119	Serine/threonine-protein kinase SIK1	Homo sapiens		 3.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794588&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605934	528826051							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126059	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H29F6N5O4/c1-28(2,42)5-6-40-13-16(12-36-40)14-7-17(25(30)31)22-18(8-14)38-39(3)24(22)15-9-19(43-4)23(20(10-15)44-27(32)33)26(41)37-21-11-29(21,34)35/h7-10,12-13,21,25,27,42H,5-6,11H2,1-4H3,(H,37,41)	ANJQPCHJDZARNJ-UHFFFAOYSA-N	794588	US20260062387, Example 119	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794588&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605934	528826051							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126060	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H29F6N5O4/c1-28(2,42)5-6-40-13-16(12-36-40)14-7-17(25(30)31)22-18(8-14)38-39(3)24(22)15-9-19(43-4)23(20(10-15)44-27(32)33)26(41)37-21-11-29(21,34)35/h7-10,12-13,21,25,27,42H,5-6,11H2,1-4H3,(H,37,41)	ANJQPCHJDZARNJ-UHFFFAOYSA-N	794588	US20260062387, Example 119	Serine/threonine-protein kinase SIK3	Homo sapiens		 0.700							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794588&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605934	528826051							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126061	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C28H27F6N5O4/c1-13(40)4-5-39-12-16(11-35-39)14-6-17(25(29)30)22-18(7-14)37-38(2)24(22)15-8-19(42-3)23(20(9-15)43-27(31)32)26(41)36-21-10-28(21,33)34/h6-9,11-13,21,25,27,40H,4-5,10H2,1-3H3,(H,36,41)	OWNPPVLGKIGASB-UHFFFAOYSA-N	794589	US20260062387, Example 120	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794589&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605991	528826052							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126062	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C28H27F6N5O4/c1-13(40)4-5-39-12-16(11-35-39)14-6-17(25(29)30)22-18(7-14)37-38(2)24(22)15-8-19(42-3)23(20(9-15)43-27(31)32)26(41)36-21-10-28(21,33)34/h6-9,11-13,21,25,27,40H,4-5,10H2,1-3H3,(H,36,41)	OWNPPVLGKIGASB-UHFFFAOYSA-N	794589	US20260062387, Example 120	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794589&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605991	528826052							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126063	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(CC[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C28H27F6N5O4/c1-13(40)4-5-39-12-16(11-35-39)14-6-17(25(29)30)22-18(7-14)37-38(2)24(22)15-8-19(42-3)23(20(9-15)43-27(31)32)26(41)36-21-10-28(21,33)34/h6-9,11-13,21,25,27,40H,4-5,10H2,1-3H3,(H,36,41)	OWNPPVLGKIGASB-UHFFFAOYSA-N	794589	US20260062387, Example 120	Serine/threonine-protein kinase SIK3	Homo sapiens		 0.700							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794589&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605991	528826052							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126064	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H]5C[C@@H](O)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H27F6N5O4/c1-39-25(15-7-20(43-2)24(21(8-15)44-28(32)33)27(42)37-22-9-29(22,34)35)23-18(26(30)31)5-14(6-19(23)38-39)16-10-36-40(12-16)11-13-3-17(41)4-13/h5-8,10,12-13,17,22,26,28,41H,3-4,9,11H2,1-2H3,(H,37,42)	HBGCODGQCIQATN-UHFFFAOYSA-N	794590	US20260062387, Example 121	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794590&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606123	528826053							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126065	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H]5C[C@@H](O)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H27F6N5O4/c1-39-25(15-7-20(43-2)24(21(8-15)44-28(32)33)27(42)37-22-9-29(22,34)35)23-18(26(30)31)5-14(6-19(23)38-39)16-10-36-40(12-16)11-13-3-17(41)4-13/h5-8,10,12-13,17,22,26,28,41H,3-4,9,11H2,1-2H3,(H,37,42)	HBGCODGQCIQATN-UHFFFAOYSA-N	794590	US20260062387, Example 121	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794590&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606123	528826053							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126066	COc1cc(-c2c3c(C(F)F)cc(-c4cnn(C[C@H]5C[C@@H](O)C5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C29H27F6N5O4/c1-39-25(15-7-20(43-2)24(21(8-15)44-28(32)33)27(42)37-22-9-29(22,34)35)23-18(26(30)31)5-14(6-19(23)38-39)16-10-36-40(12-16)11-13-3-17(41)4-13/h5-8,10,12-13,17,22,26,28,41H,3-4,9,11H2,1-2H3,(H,37,42)	HBGCODGQCIQATN-UHFFFAOYSA-N	794590	US20260062387, Example 121	Serine/threonine-protein kinase SIK3	Homo sapiens		 1.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794590&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606123	528826053							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126067	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C31H31F3N6O4/c1-39-27(19-12-23(43-2)26(24(13-19)44-29(32)33)28(41)36-17-30(34)6-7-30)25-20(14-35)10-18(11-22(25)38-39)21-15-37-40(16-21)9-8-31(42)4-3-5-31/h10-13,15-16,29,42H,3-9,17H2,1-2H3,(H,36,41)	XVPFLVPSMZGZCS-UHFFFAOYSA-N	794591	US20260062387, Example 122	Serine/threonine-protein kinase SIK1	Homo sapiens		 15.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794591&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605979	528826054							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126068	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C31H31F3N6O4/c1-39-27(19-12-23(43-2)26(24(13-19)44-29(32)33)28(41)36-17-30(34)6-7-30)25-20(14-35)10-18(11-22(25)38-39)21-15-37-40(16-21)9-8-31(42)4-3-5-31/h10-13,15-16,29,42H,3-9,17H2,1-2H3,(H,36,41)	XVPFLVPSMZGZCS-UHFFFAOYSA-N	794591	US20260062387, Example 122	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794591&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605979	528826054							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126069	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)NCC1(F)CC1	InChI=1S/C31H31F3N6O4/c1-39-27(19-12-23(43-2)26(24(13-19)44-29(32)33)28(41)36-17-30(34)6-7-30)25-20(14-35)10-18(11-22(25)38-39)21-15-37-40(16-21)9-8-31(42)4-3-5-31/h10-13,15-16,29,42H,3-9,17H2,1-2H3,(H,36,41)	XVPFLVPSMZGZCS-UHFFFAOYSA-N	794591	US20260062387, Example 122	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794591&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605979	528826054							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126070	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C30H28F4N6O4/c1-39-26(17-10-21(43-2)25(22(11-17)44-28(31)32)27(41)37-23-12-30(23,33)34)24-18(13-35)8-16(9-20(24)38-39)19-14-36-40(15-19)7-6-29(42)4-3-5-29/h8-11,14-15,23,28,42H,3-7,12H2,1-2H3,(H,37,41)	DFETUQUSLFMUOF-UHFFFAOYSA-N	794592	US20260062387, Example 123	Serine/threonine-protein kinase SIK1	Homo sapiens		 4.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794592&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606009	528826055							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126071	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C30H28F4N6O4/c1-39-26(17-10-21(43-2)25(22(11-17)44-28(31)32)27(41)37-23-12-30(23,33)34)24-18(13-35)8-16(9-20(24)38-39)19-14-36-40(15-19)7-6-29(42)4-3-5-29/h8-11,14-15,23,28,42H,3-7,12H2,1-2H3,(H,37,41)	DFETUQUSLFMUOF-UHFFFAOYSA-N	794592	US20260062387, Example 123	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794592&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606009	528826055							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126072	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C30H28F4N6O4/c1-39-26(17-10-21(43-2)25(22(11-17)44-28(31)32)27(41)37-23-12-30(23,33)34)24-18(13-35)8-16(9-20(24)38-39)19-14-36-40(15-19)7-6-29(42)4-3-5-29/h8-11,14-15,23,28,42H,3-7,12H2,1-2H3,(H,37,41)	DFETUQUSLFMUOF-UHFFFAOYSA-N	794592	US20260062387, Example 123	Serine/threonine-protein kinase SIK3	Homo sapiens		 0.600							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794592&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606009	528826055							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126073	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](O)C(F)(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H21F7N6O4/c1-39-23(13-5-17(43-2)22(18(6-13)44-25(28)29)24(42)37-19-7-26(19,30)31)21-14(8-35)3-12(4-16(21)38-39)15-9-36-40(10-15)11-20(41)27(32,33)34/h3-6,9-10,19-20,25,41H,7,11H2,1-2H3,(H,37,42)	MMCIZHWSHQROGX-UHFFFAOYSA-N	794593	US20260062387, Example 124	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794593&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606051	528826056							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126074	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](O)C(F)(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H21F7N6O4/c1-39-23(13-5-17(43-2)22(18(6-13)44-25(28)29)24(42)37-19-7-26(19,30)31)21-14(8-35)3-12(4-16(21)38-39)15-9-36-40(10-15)11-20(41)27(32,33)34/h3-6,9-10,19-20,25,41H,7,11H2,1-2H3,(H,37,42)	MMCIZHWSHQROGX-UHFFFAOYSA-N	794593	US20260062387, Example 124	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794593&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606051	528826056							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126075	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](O)C(F)(F)F)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H21F7N6O4/c1-39-23(13-5-17(43-2)22(18(6-13)44-25(28)29)24(42)37-19-7-26(19,30)31)21-14(8-35)3-12(4-16(21)38-39)15-9-36-40(10-15)11-20(41)27(32,33)34/h3-6,9-10,19-20,25,41H,7,11H2,1-2H3,(H,37,42)	MMCIZHWSHQROGX-UHFFFAOYSA-N	794593	US20260062387, Example 124	Serine/threonine-protein kinase SIK3	Homo sapiens		 1.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794593&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606051	528826056							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126076	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C24H22F2N6O4/c1-12(33)10-32-11-16(9-29-32)13-4-15(8-27)20-17(5-13)30-31(2)22(20)14-6-18(35-3)21(23(28)34)19(7-14)36-24(25)26/h4-7,9,11-12,24,33H,10H2,1-3H3,(H2,28,34)	ADYXGDVZGUQCKB-UHFFFAOYSA-N	794594	US20260062387, Example 125	Serine/threonine-protein kinase SIK1	Homo sapiens		 11.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794594&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606143	528826057							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126077	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C24H22F2N6O4/c1-12(33)10-32-11-16(9-29-32)13-4-15(8-27)20-17(5-13)30-31(2)22(20)14-6-18(35-3)21(23(28)34)19(7-14)36-24(25)26/h4-7,9,11-12,24,33H,10H2,1-3H3,(H2,28,34)	ADYXGDVZGUQCKB-UHFFFAOYSA-N	794594	US20260062387, Example 125	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794594&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606143	528826057							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126078	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C24H22F2N6O4/c1-12(33)10-32-11-16(9-29-32)13-4-15(8-27)20-17(5-13)30-31(2)22(20)14-6-18(35-3)21(23(28)34)19(7-14)36-24(25)26/h4-7,9,11-12,24,33H,10H2,1-3H3,(H2,28,34)	ADYXGDVZGUQCKB-UHFFFAOYSA-N	794594	US20260062387, Example 125	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794594&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606143	528826057							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126079	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)(F)F)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C25H21F3N6O2/c1-13-9-30-24(35)22-18(13)5-15(7-20(22)36-3)23-21-16(8-29)4-14(6-19(21)32-33(23)2)17-10-31-34(11-17)12-25(26,27)28/h4-7,10-11,13H,9,12H2,1-3H3,(H,30,35)	PCHYAPPWSRLYGF-UHFFFAOYSA-N	794595	US20260062387, Example 126	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794595&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606003	528826058							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126080	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)(F)F)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C25H21F3N6O2/c1-13-9-30-24(35)22-18(13)5-15(7-20(22)36-3)23-21-16(8-29)4-14(6-19(21)32-33(23)2)17-10-31-34(11-17)12-25(26,27)28/h4-7,10-11,13H,9,12H2,1-3H3,(H,30,35)	PCHYAPPWSRLYGF-UHFFFAOYSA-N	794595	US20260062387, Example 126	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794595&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606003	528826058							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126081	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)(F)F)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C25H21F3N6O2/c1-13-9-30-24(35)22-18(13)5-15(7-20(22)36-3)23-21-16(8-29)4-14(6-19(21)32-33(23)2)17-10-31-34(11-17)12-25(26,27)28/h4-7,10-11,13H,9,12H2,1-3H3,(H,30,35)	PCHYAPPWSRLYGF-UHFFFAOYSA-N	794595	US20260062387, Example 126	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794595&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606003	528826058							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126082	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H26N6O3/c1-15-12-28-26(33)24-20(15)8-17(10-22(24)35-4)25-23-18(11-27)7-16(9-21(23)30-31(25)2)19-13-29-32(14-19)5-6-34-3/h7-10,13-15H,5-6,12H2,1-4H3,(H,28,33)	HWFAYGTZTFHPIZ-UHFFFAOYSA-N	794596	US20260062387, Example 127	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794596&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606196	528826059							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126083	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H26N6O3/c1-15-12-28-26(33)24-20(15)8-17(10-22(24)35-4)25-23-18(11-27)7-16(9-21(23)30-31(25)2)19-13-29-32(14-19)5-6-34-3/h7-10,13-15H,5-6,12H2,1-4H3,(H,28,33)	HWFAYGTZTFHPIZ-UHFFFAOYSA-N	794596	US20260062387, Example 127	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794596&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606196	528826059							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126084	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H26N6O3/c1-15-12-28-26(33)24-20(15)8-17(10-22(24)35-4)25-23-18(11-27)7-16(9-21(23)30-31(25)2)19-13-29-32(14-19)5-6-34-3/h7-10,13-15H,5-6,12H2,1-4H3,(H,28,33)	HWFAYGTZTFHPIZ-UHFFFAOYSA-N	794596	US20260062387, Example 127	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794596&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606196	528826059							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126085	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(F)F)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-3)22-20-15(8-27)4-13(6-18(20)30-31(22)2)16-10-29-32(11-16)24(25)26/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	NCWASZNPLNJLPQ-UHFFFAOYSA-N	794597	US20260062387, Example 128	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794597&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606193	528826060							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126086	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(F)F)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-3)22-20-15(8-27)4-13(6-18(20)30-31(22)2)16-10-29-32(11-16)24(25)26/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	NCWASZNPLNJLPQ-UHFFFAOYSA-N	794597	US20260062387, Example 128	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.000							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794597&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606193	528826060							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126087	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(F)F)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-3)22-20-15(8-27)4-13(6-18(20)30-31(22)2)16-10-29-32(11-16)24(25)26/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	NCWASZNPLNJLPQ-UHFFFAOYSA-N	794597	US20260062387, Example 128	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794597&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606193	528826060							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126088	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C25H24N6O2/c1-25(2)13-27-24(32)22-18(25)7-15(9-20(22)33-5)23-21-16(10-26)6-14(8-19(21)29-31(23)4)17-11-28-30(3)12-17/h6-9,11-12H,13H2,1-5H3,(H,27,32)	MWWVCGVDOWVSRZ-UHFFFAOYSA-N	794598	US20260062387, Example 129	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794598&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605936	528826061							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126089	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C25H24N6O2/c1-25(2)13-27-24(32)22-18(25)7-15(9-20(22)33-5)23-21-16(10-26)6-14(8-19(21)29-31(23)4)17-11-28-30(3)12-17/h6-9,11-12H,13H2,1-5H3,(H,27,32)	MWWVCGVDOWVSRZ-UHFFFAOYSA-N	794598	US20260062387, Example 129	Serine/threonine-protein kinase SIK2	Homo sapiens		 0.900							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794598&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605936	528826061							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126090	COc1cc(-c2c3c(C#N)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C25H24N6O2/c1-25(2)13-27-24(32)22-18(25)7-15(9-20(22)33-5)23-21-16(10-26)6-14(8-19(21)29-31(23)4)17-11-28-30(3)12-17/h6-9,11-12H,13H2,1-5H3,(H,27,32)	MWWVCGVDOWVSRZ-UHFFFAOYSA-N	794598	US20260062387, Example 129	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794598&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605936	528826061							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126091	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H21F2N5O4/c1-28-10-13(9-26-28)11-5-14-18(15(6-11)31-3)20(29(2)27-14)12-7-16(32-4)19(21(25)30)17(8-12)33-22(23)24/h5-10,22H,1-4H3,(H2,25,30)	NPARBXUKUBQNSC-UHFFFAOYSA-N	794599	US20260062387, Example 130	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.9							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794599&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605961	528826062							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126092	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H21F2N5O4/c1-28-10-13(9-26-28)11-5-14-18(15(6-11)31-3)20(29(2)27-14)12-7-16(32-4)19(21(25)30)17(8-12)33-22(23)24/h5-10,22H,1-4H3,(H2,25,30)	NPARBXUKUBQNSC-UHFFFAOYSA-N	794599	US20260062387, Example 130	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794599&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605961	528826062							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126093	COc1cc(-c2c3c(OC)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H21F2N5O4/c1-28-10-13(9-26-28)11-5-14-18(15(6-11)31-3)20(29(2)27-14)12-7-16(32-4)19(21(25)30)17(8-12)33-22(23)24/h5-10,22H,1-4H3,(H2,25,30)	NPARBXUKUBQNSC-UHFFFAOYSA-N	794599	US20260062387, Example 130	Serine/threonine-protein kinase SIK3	Homo sapiens		 16.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794599&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605961	528826062							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126094	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H19F4N5O4/c1-30-9-12(8-28-30)10-4-13-17(15(5-10)34-21(23)24)19(31(2)29-13)11-6-14(33-3)18(20(27)32)16(7-11)35-22(25)26/h4-9,21-22H,1-3H3,(H2,27,32)	ZMGRRNQVBVLYOV-UHFFFAOYSA-N	794600	US20260062387, Example 131	Serine/threonine-protein kinase SIK1	Homo sapiens		 12.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794600&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605987	528826063							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126095	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H19F4N5O4/c1-30-9-12(8-28-30)10-4-13-17(15(5-10)34-21(23)24)19(31(2)29-13)11-6-14(33-3)18(20(27)32)16(7-11)35-22(25)26/h4-9,21-22H,1-3H3,(H2,27,32)	ZMGRRNQVBVLYOV-UHFFFAOYSA-N	794600	US20260062387, Example 131	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794600&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605987	528826063							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126096	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C22H19F4N5O4/c1-30-9-12(8-28-30)10-4-13-17(15(5-10)34-21(23)24)19(31(2)29-13)11-6-14(33-3)18(20(27)32)16(7-11)35-22(25)26/h4-9,21-22H,1-3H3,(H2,27,32)	ZMGRRNQVBVLYOV-UHFFFAOYSA-N	794600	US20260062387, Example 131	Serine/threonine-protein kinase SIK3	Homo sapiens		 16.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794600&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605987	528826063							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126097	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C24H22F2N6O3/c1-12(2)32-11-16(10-29-32)13-5-15(9-27)20-17(6-13)30-31(3)22(20)14-7-18(34-4)21(23(28)33)19(8-14)35-24(25)26/h5-8,10-12,24H,1-4H3,(H2,28,33)	MSIBVGAKLCXUDI-UHFFFAOYSA-N	794601	US20260062387, Example 132	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794601&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605997	528826064							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126098	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C24H22F2N6O3/c1-12(2)32-11-16(10-29-32)13-5-15(9-27)20-17(6-13)30-31(3)22(20)14-7-18(34-4)21(23(28)33)19(8-14)35-24(25)26/h5-8,10-12,24H,1-4H3,(H2,28,33)	MSIBVGAKLCXUDI-UHFFFAOYSA-N	794601	US20260062387, Example 132	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794601&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605997	528826064							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126099	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C24H22F2N6O3/c1-12(2)32-11-16(10-29-32)13-5-15(9-27)20-17(6-13)30-31(3)22(20)14-7-18(34-4)21(23(28)33)19(8-14)35-24(25)26/h5-8,10-12,24H,1-4H3,(H2,28,33)	MSIBVGAKLCXUDI-UHFFFAOYSA-N	794601	US20260062387, Example 132	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794601&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605997	528826064							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126100	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H22F2N6O4/c1-31-22(14-8-18(35-3)21(23(28)33)19(9-14)36-24(25)26)20-15(10-27)6-13(7-17(20)30-31)16-11-29-32(12-16)4-5-34-2/h6-9,11-12,24H,4-5H2,1-3H3,(H2,28,33)	OGAUSGPCWNXLBI-UHFFFAOYSA-N	794602	US20260062387, Example 133	Serine/threonine-protein kinase SIK1	Homo sapiens		 13.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794602&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606229	528826065							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126101	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H22F2N6O4/c1-31-22(14-8-18(35-3)21(23(28)33)19(9-14)36-24(25)26)20-15(10-27)6-13(7-17(20)30-31)16-11-29-32(12-16)4-5-34-2/h6-9,11-12,24H,4-5H2,1-3H3,(H2,28,33)	OGAUSGPCWNXLBI-UHFFFAOYSA-N	794602	US20260062387, Example 133	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794602&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606229	528826065							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126102	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H22F2N6O4/c1-31-22(14-8-18(35-3)21(23(28)33)19(9-14)36-24(25)26)20-15(10-27)6-13(7-17(20)30-31)16-11-29-32(12-16)4-5-34-2/h6-9,11-12,24H,4-5H2,1-3H3,(H2,28,33)	OGAUSGPCWNXLBI-UHFFFAOYSA-N	794602	US20260062387, Example 133	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794602&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606229	528826065							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126103	COCCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H23F4N5O4/c1-32-21(13-8-17(36-3)20(23(29)34)18(9-13)37-24(27)28)19-15(22(25)26)6-12(7-16(19)31-32)14-10-30-33(11-14)4-5-35-2/h6-11,22,24H,4-5H2,1-3H3,(H2,29,34)	HDHCQZUONNPJJK-UHFFFAOYSA-N	794603	US20260062387, Example 134	Serine/threonine-protein kinase SIK1	Homo sapiens		 13.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794603&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606125	528826066							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126104	COCCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H23F4N5O4/c1-32-21(13-8-17(36-3)20(23(29)34)18(9-13)37-24(27)28)19-15(22(25)26)6-12(7-16(19)31-32)14-10-30-33(11-14)4-5-35-2/h6-11,22,24H,4-5H2,1-3H3,(H2,29,34)	HDHCQZUONNPJJK-UHFFFAOYSA-N	794603	US20260062387, Example 134	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794603&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606125	528826066							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126105	COCCn1cc(-c2cc(C(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H23F4N5O4/c1-32-21(13-8-17(36-3)20(23(29)34)18(9-13)37-24(27)28)19-15(22(25)26)6-12(7-16(19)31-32)14-10-30-33(11-14)4-5-35-2/h6-11,22,24H,4-5H2,1-3H3,(H2,29,34)	HDHCQZUONNPJJK-UHFFFAOYSA-N	794603	US20260062387, Example 134	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794603&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606125	528826066							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126106	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H24F2N6O3/c1-13(2)11-33-12-17(10-30-33)14-5-16(9-28)21-18(6-14)31-32(3)23(21)15-7-19(35-4)22(24(29)34)20(8-15)36-25(26)27/h5-8,10,12-13,25H,11H2,1-4H3,(H2,29,34)	YMXJIIKNKARXLM-UHFFFAOYSA-N	794604	US20260062387, Example 135	Serine/threonine-protein kinase SIK1	Homo sapiens		 17.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794604&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606065	528826067							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126107	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H24F2N6O3/c1-13(2)11-33-12-17(10-30-33)14-5-16(9-28)21-18(6-14)31-32(3)23(21)15-7-19(35-4)22(24(29)34)20(8-15)36-25(26)27/h5-8,10,12-13,25H,11H2,1-4H3,(H2,29,34)	YMXJIIKNKARXLM-UHFFFAOYSA-N	794604	US20260062387, Example 135	Serine/threonine-protein kinase SIK2	Homo sapiens		 6.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794604&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606065	528826067							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126108	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H24F2N6O3/c1-13(2)11-33-12-17(10-30-33)14-5-16(9-28)21-18(6-14)31-32(3)23(21)15-7-19(35-4)22(24(29)34)20(8-15)36-25(26)27/h5-8,10,12-13,25H,11H2,1-4H3,(H2,29,34)	YMXJIIKNKARXLM-UHFFFAOYSA-N	794604	US20260062387, Example 135	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794604&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606065	528826067							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126109	CCOc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC)c(C(N)=O)c(OC(F)F)c3)c12	InChI=1S/C23H23F2N5O4/c1-5-33-17-7-12(14-10-27-29(2)11-14)6-15-19(17)21(30(3)28-15)13-8-16(32-4)20(22(26)31)18(9-13)34-23(24)25/h6-11,23H,5H2,1-4H3,(H2,26,31)	YUYOYLFMXSKUQU-UHFFFAOYSA-N	794605	US20260062387, Example 136	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794605&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606183	528826068							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126110	CCOc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC)c(C(N)=O)c(OC(F)F)c3)c12	InChI=1S/C23H23F2N5O4/c1-5-33-17-7-12(14-10-27-29(2)11-14)6-15-19(17)21(30(3)28-15)13-8-16(32-4)20(22(26)31)18(9-13)34-23(24)25/h6-11,23H,5H2,1-4H3,(H2,26,31)	YUYOYLFMXSKUQU-UHFFFAOYSA-N	794605	US20260062387, Example 136	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794605&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606183	528826068							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126111	CCOc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC)c(C(N)=O)c(OC(F)F)c3)c12	InChI=1S/C23H23F2N5O4/c1-5-33-17-7-12(14-10-27-29(2)11-14)6-15-19(17)21(30(3)28-15)13-8-16(32-4)20(22(26)31)18(9-13)34-23(24)25/h6-11,23H,5H2,1-4H3,(H2,26,31)	YUYOYLFMXSKUQU-UHFFFAOYSA-N	794605	US20260062387, Example 136	Serine/threonine-protein kinase SIK3	Homo sapiens		 13.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794605&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606183	528826068							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126112	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C27H26F2N6O4/c1-34-24(16-10-20(38-2)23(25(31)36)21(11-16)39-26(28)29)22-17(12-30)8-15(9-19(22)33-34)18-13-32-35(14-18)7-6-27(37)4-3-5-27/h8-11,13-14,26,37H,3-7H2,1-2H3,(H2,31,36)	IDNGIPSTRVIEEH-UHFFFAOYSA-N	794606	US20260062387, Example 137	Serine/threonine-protein kinase SIK1	Homo sapiens		 11.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794606&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605975	528826069							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126113	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C27H26F2N6O4/c1-34-24(16-10-20(38-2)23(25(31)36)21(11-16)39-26(28)29)22-17(12-30)8-15(9-19(22)33-34)18-13-32-35(14-18)7-6-27(37)4-3-5-27/h8-11,13-14,26,37H,3-7H2,1-2H3,(H2,31,36)	IDNGIPSTRVIEEH-UHFFFAOYSA-N	794606	US20260062387, Example 137	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794606&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605975	528826069							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126114	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC5(O)CCC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C27H26F2N6O4/c1-34-24(16-10-20(38-2)23(25(31)36)21(11-16)39-26(28)29)22-17(12-30)8-15(9-19(22)33-34)18-13-32-35(14-18)7-6-27(37)4-3-5-27/h8-11,13-14,26,37H,3-7H2,1-2H3,(H2,31,36)	IDNGIPSTRVIEEH-UHFFFAOYSA-N	794606	US20260062387, Example 137	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794606&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605975	528826069							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126115	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H22F2N6O3/c1-32-23(15-7-19(35-2)22(24(29)34)20(8-15)36-25(26)27)21-16(9-28)5-14(6-18(21)31-32)17-10-30-33(12-17)11-13-3-4-13/h5-8,10,12-13,25H,3-4,11H2,1-2H3,(H2,29,34)	WHMSFNYQMDPFJL-UHFFFAOYSA-N	794607	US20260062387, Example 138	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.9							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794607&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606190	528826070							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126116	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H22F2N6O3/c1-32-23(15-7-19(35-2)22(24(29)34)20(8-15)36-25(26)27)21-16(9-28)5-14(6-18(21)31-32)17-10-30-33(12-17)11-13-3-4-13/h5-8,10,12-13,25H,3-4,11H2,1-2H3,(H2,29,34)	WHMSFNYQMDPFJL-UHFFFAOYSA-N	794607	US20260062387, Example 138	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794607&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606190	528826070							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126117	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H22F2N6O3/c1-32-23(15-7-19(35-2)22(24(29)34)20(8-15)36-25(26)27)21-16(9-28)5-14(6-18(21)31-32)17-10-30-33(12-17)11-13-3-4-13/h5-8,10,12-13,25H,3-4,11H2,1-2H3,(H2,29,34)	WHMSFNYQMDPFJL-UHFFFAOYSA-N	794607	US20260062387, Example 138	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794607&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606190	528826070							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126118	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H26N6O2/c1-6-32-13-18(12-29-32)15-7-17(11-27)22-20(9-15)30-31(4)24(22)16-8-19-23(21(10-16)34-5)25(33)28-14-26(19,2)3/h7-10,12-13H,6,14H2,1-5H3,(H,28,33)	ZNFOXCVZVIZOHH-UHFFFAOYSA-N	794608	US20260062387, Example 139	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794608&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606011	528826071							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126119	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H26N6O2/c1-6-32-13-18(12-29-32)15-7-17(11-27)22-20(9-15)30-31(4)24(22)16-8-19-23(21(10-16)34-5)25(33)28-14-26(19,2)3/h7-10,12-13H,6,14H2,1-5H3,(H,28,33)	ZNFOXCVZVIZOHH-UHFFFAOYSA-N	794608	US20260062387, Example 139	Serine/threonine-protein kinase SIK2	Homo sapiens		 8.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794608&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606011	528826071							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126120	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H26N6O2/c1-6-32-13-18(12-29-32)15-7-17(11-27)22-20(9-15)30-31(4)24(22)16-8-19-23(21(10-16)34-5)25(33)28-14-26(19,2)3/h7-10,12-13H,6,14H2,1-5H3,(H,28,33)	ZNFOXCVZVIZOHH-UHFFFAOYSA-N	794608	US20260062387, Example 139	Serine/threonine-protein kinase SIK3	Homo sapiens		 12.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794608&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606011	528826071							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126121	CCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C27H28N6O2/c1-6-7-33-14-19(13-30-33)16-8-18(12-28)23-21(10-16)31-32(4)25(23)17-9-20-24(22(11-17)35-5)26(34)29-15-27(20,2)3/h8-11,13-14H,6-7,15H2,1-5H3,(H,29,34)	ZOPWMRVRIYWFRE-UHFFFAOYSA-N	794609	US20260062387, Example 140	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794609&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606145	528826072							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126122	CCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C27H28N6O2/c1-6-7-33-14-19(13-30-33)16-8-18(12-28)23-21(10-16)31-32(4)25(23)17-9-20-24(22(11-17)35-5)26(34)29-15-27(20,2)3/h8-11,13-14H,6-7,15H2,1-5H3,(H,29,34)	ZOPWMRVRIYWFRE-UHFFFAOYSA-N	794609	US20260062387, Example 140	Serine/threonine-protein kinase SIK2	Homo sapiens		 12.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794609&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606145	528826072							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126123	CCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C27H28N6O2/c1-6-7-33-14-19(13-30-33)16-8-18(12-28)23-21(10-16)31-32(4)25(23)17-9-20-24(22(11-17)35-5)26(34)29-15-27(20,2)3/h8-11,13-14H,6-7,15H2,1-5H3,(H,29,34)	ZOPWMRVRIYWFRE-UHFFFAOYSA-N	794609	US20260062387, Example 140	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794609&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606145	528826072							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126124	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C23H20F2N6O3/c1-4-31-11-15(10-28-31)12-5-14(9-26)19-16(6-12)29-30(2)21(19)13-7-17(33-3)20(22(27)32)18(8-13)34-23(24)25/h5-8,10-11,23H,4H2,1-3H3,(H2,27,32)	UNHIGMRMVLJYND-UHFFFAOYSA-N	794610	US20260062387, Example 141	Serine/threonine-protein kinase SIK1	Homo sapiens		 17.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794610&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606132	528826073							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126125	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C23H20F2N6O3/c1-4-31-11-15(10-28-31)12-5-14(9-26)19-16(6-12)29-30(2)21(19)13-7-17(33-3)20(22(27)32)18(8-13)34-23(24)25/h5-8,10-11,23H,4H2,1-3H3,(H2,27,32)	UNHIGMRMVLJYND-UHFFFAOYSA-N	794610	US20260062387, Example 141	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794610&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606132	528826073							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126126	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C23H20F2N6O3/c1-4-31-11-15(10-28-31)12-5-14(9-26)19-16(6-12)29-30(2)21(19)13-7-17(33-3)20(22(27)32)18(8-13)34-23(24)25/h5-8,10-11,23H,4H2,1-3H3,(H2,27,32)	UNHIGMRMVLJYND-UHFFFAOYSA-N	794610	US20260062387, Example 141	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794610&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606132	528826073							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126127	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C26H26F2N6O4/c1-26(2,36)5-6-34-13-17(12-31-34)14-7-16(11-29)21-18(8-14)32-33(3)23(21)15-9-19(37-4)22(24(30)35)20(10-15)38-25(27)28/h7-10,12-13,25,36H,5-6H2,1-4H3,(H2,30,35)	IZFJDDMOSKKQHO-UHFFFAOYSA-N	794611	US20260062387, Example 142	Serine/threonine-protein kinase SIK1	Homo sapiens		 16.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794611&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605970	528826074							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126128	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C26H26F2N6O4/c1-26(2,36)5-6-34-13-17(12-31-34)14-7-16(11-29)21-18(8-14)32-33(3)23(21)15-9-19(37-4)22(24(30)35)20(10-15)38-25(27)28/h7-10,12-13,25,36H,5-6H2,1-4H3,(H2,30,35)	IZFJDDMOSKKQHO-UHFFFAOYSA-N	794611	US20260062387, Example 142	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794611&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605970	528826074							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126129	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)(C)O)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C26H26F2N6O4/c1-26(2,36)5-6-34-13-17(12-31-34)14-7-16(11-29)21-18(8-14)32-33(3)23(21)15-9-19(37-4)22(24(30)35)20(10-15)38-25(27)28/h7-10,12-13,25,36H,5-6H2,1-4H3,(H2,30,35)	IZFJDDMOSKKQHO-UHFFFAOYSA-N	794611	US20260062387, Example 142	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794611&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605970	528826074							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126130	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C27H28N6O3/c1-27(2)15-29-26(34)24-20(27)9-17(11-22(24)36-5)25-23-18(12-28)8-16(10-21(23)31-32(25)3)19-13-30-33(14-19)6-7-35-4/h8-11,13-14H,6-7,15H2,1-5H3,(H,29,34)	WTKDOYNFDNREII-UHFFFAOYSA-N	794612	US20260062387, Example 143	Serine/threonine-protein kinase SIK1	Homo sapiens		 10.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794612&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606093	528826075							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126131	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C27H28N6O3/c1-27(2)15-29-26(34)24-20(27)9-17(11-22(24)36-5)25-23-18(12-28)8-16(10-21(23)31-32(25)3)19-13-30-33(14-19)6-7-35-4/h8-11,13-14H,6-7,15H2,1-5H3,(H,29,34)	WTKDOYNFDNREII-UHFFFAOYSA-N	794612	US20260062387, Example 143	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794612&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606093	528826075							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126132	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C27H28N6O3/c1-27(2)15-29-26(34)24-20(27)9-17(11-22(24)36-5)25-23-18(12-28)8-16(10-21(23)31-32(25)3)19-13-30-33(14-19)6-7-35-4/h8-11,13-14H,6-7,15H2,1-5H3,(H,29,34)	WTKDOYNFDNREII-UHFFFAOYSA-N	794612	US20260062387, Example 143	Serine/threonine-protein kinase SIK3	Homo sapiens		 8.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794612&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606093	528826075							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126133	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C27H28N6O3/c1-15(34)12-33-13-19(11-30-33)16-6-18(10-28)23-21(8-16)31-32(4)25(23)17-7-20-24(22(9-17)36-5)26(35)29-14-27(20,2)3/h6-9,11,13,15,34H,12,14H2,1-5H3,(H,29,35)	VNOIADOANUAEMF-UHFFFAOYSA-N	794613	US20260062387, Example 144	Serine/threonine-protein kinase SIK1	Homo sapiens		 10.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794613&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606005	528826076							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126134	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C27H28N6O3/c1-15(34)12-33-13-19(11-30-33)16-6-18(10-28)23-21(8-16)31-32(4)25(23)17-7-20-24(22(9-17)36-5)26(35)29-14-27(20,2)3/h6-9,11,13,15,34H,12,14H2,1-5H3,(H,29,35)	VNOIADOANUAEMF-UHFFFAOYSA-N	794613	US20260062387, Example 144	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794613&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606005	528826076							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126135	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@H](C)O)c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C27H28N6O3/c1-15(34)12-33-13-19(11-30-33)16-6-18(10-28)23-21(8-16)31-32(4)25(23)17-7-20-24(22(9-17)36-5)26(35)29-14-27(20,2)3/h6-9,11,13,15,34H,12,14H2,1-5H3,(H,29,35)	VNOIADOANUAEMF-UHFFFAOYSA-N	794613	US20260062387, Example 144	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794613&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606005	528826076							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126136	COc1cc(-c2c3c(OCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H23F2N5O5/c1-29-11-14(10-27-29)12-6-15-19(17(7-12)34-5-4-31)21(30(2)28-15)13-8-16(33-3)20(22(26)32)18(9-13)35-23(24)25/h6-11,23,31H,4-5H2,1-3H3,(H2,26,32)	KLUIVJZIVBWEGS-UHFFFAOYSA-N	794614	US20260062387, Example 145	Serine/threonine-protein kinase SIK1	Homo sapiens		 10.3							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794614&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606101	528826077							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126137	COc1cc(-c2c3c(OCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H23F2N5O5/c1-29-11-14(10-27-29)12-6-15-19(17(7-12)34-5-4-31)21(30(2)28-15)13-8-16(33-3)20(22(26)32)18(9-13)35-23(24)25/h6-11,23,31H,4-5H2,1-3H3,(H2,26,32)	KLUIVJZIVBWEGS-UHFFFAOYSA-N	794614	US20260062387, Example 145	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794614&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606101	528826077							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126138	COc1cc(-c2c3c(OCCO)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H23F2N5O5/c1-29-11-14(10-27-29)12-6-15-19(17(7-12)34-5-4-31)21(30(2)28-15)13-8-16(33-3)20(22(26)32)18(9-13)35-23(24)25/h6-11,23,31H,4-5H2,1-3H3,(H2,26,32)	KLUIVJZIVBWEGS-UHFFFAOYSA-N	794614	US20260062387, Example 145	Serine/threonine-protein kinase SIK3	Homo sapiens		 19.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794614&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606101	528826077							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126139	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)(F)F)c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C26H23F3N6O2/c1-25(2)12-31-24(36)22-18(25)6-15(8-20(22)37-4)23-21-16(9-30)5-14(7-19(21)33-34(23)3)17-10-32-35(11-17)13-26(27,28)29/h5-8,10-11H,12-13H2,1-4H3,(H,31,36)	DKKQLLNEGCDUQD-UHFFFAOYSA-N	794615	US20260062387, Example 146	Serine/threonine-protein kinase SIK1	Homo sapiens		 12.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794615&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606181	528826078							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126140	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)(F)F)c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C26H23F3N6O2/c1-25(2)12-31-24(36)22-18(25)6-15(8-20(22)37-4)23-21-16(9-30)5-14(7-19(21)33-34(23)3)17-10-32-35(11-17)13-26(27,28)29/h5-8,10-11H,12-13H2,1-4H3,(H,31,36)	DKKQLLNEGCDUQD-UHFFFAOYSA-N	794615	US20260062387, Example 146	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794615&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606181	528826078							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126141	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(F)(F)F)c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C26H23F3N6O2/c1-25(2)12-31-24(36)22-18(25)6-15(8-20(22)37-4)23-21-16(9-30)5-14(7-19(21)33-34(23)3)17-10-32-35(11-17)13-26(27,28)29/h5-8,10-11H,12-13H2,1-4H3,(H,31,36)	DKKQLLNEGCDUQD-UHFFFAOYSA-N	794615	US20260062387, Example 146	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794615&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606181	528826078							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126142	COc1cc(-c2c3c(C#N)cc(-c4cn[nH]c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C24H22N6O2/c1-24(2)12-26-23(31)21-17(24)6-14(8-19(21)32-4)22-20-15(9-25)5-13(16-10-27-28-11-16)7-18(20)29-30(22)3/h5-8,10-11H,12H2,1-4H3,(H,26,31)(H,27,28)	KMSQGRSGIAWYHK-UHFFFAOYSA-N	794616	US20260062387, Example 147	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794616&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606206	528826079							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126143	COc1cc(-c2c3c(C#N)cc(-c4cn[nH]c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C24H22N6O2/c1-24(2)12-26-23(31)21-17(24)6-14(8-19(21)32-4)22-20-15(9-25)5-13(16-10-27-28-11-16)7-18(20)29-30(22)3/h5-8,10-11H,12H2,1-4H3,(H,26,31)(H,27,28)	KMSQGRSGIAWYHK-UHFFFAOYSA-N	794616	US20260062387, Example 147	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794616&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606206	528826079							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126144	COc1cc(-c2c3c(C#N)cc(-c4cn[nH]c4)cc3nn2C)cc2c1C(=O)NCC2(C)C	InChI=1S/C24H22N6O2/c1-24(2)12-26-23(31)21-17(24)6-14(8-19(21)32-4)22-20-15(9-25)5-13(16-10-27-28-11-16)7-18(20)29-30(22)3/h5-8,10-11H,12H2,1-4H3,(H,26,31)(H,27,28)	KMSQGRSGIAWYHK-UHFFFAOYSA-N	794616	US20260062387, Example 147	Serine/threonine-protein kinase SIK3	Homo sapiens		 13.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794616&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606206	528826079							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126145	COc1cc(-c2c3c(C#N)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C24H18F4N6O3/c1-34-21(19-13(8-29)3-11(4-15(19)33-34)14-9-30-31-10-14)12-5-16(36-2)20(17(6-12)37-23(25)26)22(35)32-18-7-24(18,27)28/h3-6,9-10,18,23H,7H2,1-2H3,(H,30,31)(H,32,35)	FJSPLAWERLZEMY-UHFFFAOYSA-N	794617	US20260062387, Example 148	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794617&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605988	528826080							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126146	COc1cc(-c2c3c(C#N)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C24H18F4N6O3/c1-34-21(19-13(8-29)3-11(4-15(19)33-34)14-9-30-31-10-14)12-5-16(36-2)20(17(6-12)37-23(25)26)22(35)32-18-7-24(18,27)28/h3-6,9-10,18,23H,7H2,1-2H3,(H,30,31)(H,32,35)	FJSPLAWERLZEMY-UHFFFAOYSA-N	794617	US20260062387, Example 148	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794617&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605988	528826080							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126147	COc1cc(-c2c3c(C#N)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C24H18F4N6O3/c1-34-21(19-13(8-29)3-11(4-15(19)33-34)14-9-30-31-10-14)12-5-16(36-2)20(17(6-12)37-23(25)26)22(35)32-18-7-24(18,27)28/h3-6,9-10,18,23H,7H2,1-2H3,(H,30,31)(H,32,35)	FJSPLAWERLZEMY-UHFFFAOYSA-N	794617	US20260062387, Example 148	Serine/threonine-protein kinase SIK3	Homo sapiens		 1.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794617&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605988	528826080							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126148	COc1cc(-c2c3c(C#N)cc(-c4cc[nH]n4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C24H18F4N6O3/c1-34-21(19-13(10-29)5-11(6-15(19)33-34)14-3-4-30-32-14)12-7-16(36-2)20(17(8-12)37-23(25)26)22(35)31-18-9-24(18,27)28/h3-8,18,23H,9H2,1-2H3,(H,30,32)(H,31,35)	UNXLYLOJKLORDN-UHFFFAOYSA-N	794618	US20260062387, Example 149	Serine/threonine-protein kinase SIK1	Homo sapiens		 10.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794618&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605983	528826081							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126149	COc1cc(-c2c3c(C#N)cc(-c4cc[nH]n4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C24H18F4N6O3/c1-34-21(19-13(10-29)5-11(6-15(19)33-34)14-3-4-30-32-14)12-7-16(36-2)20(17(8-12)37-23(25)26)22(35)31-18-9-24(18,27)28/h3-8,18,23H,9H2,1-2H3,(H,30,32)(H,31,35)	UNXLYLOJKLORDN-UHFFFAOYSA-N	794618	US20260062387, Example 149	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794618&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605983	528826081							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126150	COc1cc(-c2c3c(C#N)cc(-c4cc[nH]n4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C24H18F4N6O3/c1-34-21(19-13(10-29)5-11(6-15(19)33-34)14-3-4-30-32-14)12-7-16(36-2)20(17(8-12)37-23(25)26)22(35)31-18-9-24(18,27)28/h3-8,18,23H,9H2,1-2H3,(H,30,32)(H,31,35)	UNXLYLOJKLORDN-UHFFFAOYSA-N	794618	US20260062387, Example 149	Serine/threonine-protein kinase SIK3	Homo sapiens		 1.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794618&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605983	528826081							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126151	COc1cc(-c2c3c(C(F)F)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C24H19F6N5O3/c1-35-20(18-13(21(25)26)3-10(4-14(18)34-35)12-8-31-32-9-12)11-5-15(37-2)19(16(6-11)38-23(27)28)22(36)33-17-7-24(17,29)30/h3-6,8-9,17,21,23H,7H2,1-2H3,(H,31,32)(H,33,36)	LKNLOANQLACMFO-UHFFFAOYSA-N	794619	US20260062387, Example 150	Serine/threonine-protein kinase SIK1	Homo sapiens		 10.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794619&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606124	528826082							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126152	COc1cc(-c2c3c(C(F)F)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C24H19F6N5O3/c1-35-20(18-13(21(25)26)3-10(4-14(18)34-35)12-8-31-32-9-12)11-5-15(37-2)19(16(6-11)38-23(27)28)22(36)33-17-7-24(17,29)30/h3-6,8-9,17,21,23H,7H2,1-2H3,(H,31,32)(H,33,36)	LKNLOANQLACMFO-UHFFFAOYSA-N	794619	US20260062387, Example 150	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794619&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606124	528826082							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126153	COc1cc(-c2c3c(C(F)F)cc(-c4cn[nH]c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C24H19F6N5O3/c1-35-20(18-13(21(25)26)3-10(4-14(18)34-35)12-8-31-32-9-12)11-5-15(37-2)19(16(6-11)38-23(27)28)22(36)33-17-7-24(17,29)30/h3-6,8-9,17,21,23H,7H2,1-2H3,(H,31,32)(H,33,36)	LKNLOANQLACMFO-UHFFFAOYSA-N	794619	US20260062387, Example 150	Serine/threonine-protein kinase SIK3	Homo sapiens		 1.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794619&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606124	528826082							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126154	COCCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C28H30N6O3/c1-28(2)16-30-27(35)25-21(28)10-18(12-23(25)37-5)26-24-19(13-29)9-17(11-22(24)32-33(26)3)20-14-31-34(15-20)7-6-8-36-4/h9-12,14-15H,6-8,16H2,1-5H3,(H,30,35)	DQIDDDUAJYIBPO-UHFFFAOYSA-N	794620	US20260062387, Example 151	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794620&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606228	528826083							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126155	COCCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C28H30N6O3/c1-28(2)16-30-27(35)25-21(28)10-18(12-23(25)37-5)26-24-19(13-29)9-17(11-22(24)32-33(26)3)20-14-31-34(15-20)7-6-8-36-4/h9-12,14-15H,6-8,16H2,1-5H3,(H,30,35)	DQIDDDUAJYIBPO-UHFFFAOYSA-N	794620	US20260062387, Example 151	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794620&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606228	528826083							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126156	COCCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C28H30N6O3/c1-28(2)16-30-27(35)25-21(28)10-18(12-23(25)37-5)26-24-19(13-29)9-17(11-22(24)32-33(26)3)20-14-31-34(15-20)7-6-8-36-4/h9-12,14-15H,6-8,16H2,1-5H3,(H,30,35)	DQIDDDUAJYIBPO-UHFFFAOYSA-N	794620	US20260062387, Example 151	Serine/threonine-protein kinase SIK3	Homo sapiens		 14.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794620&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606228	528826083							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126157	CCOCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C28H30N6O3/c1-6-37-8-7-34-15-20(14-31-34)17-9-19(13-29)24-22(11-17)32-33(4)26(24)18-10-21-25(23(12-18)36-5)27(35)30-16-28(21,2)3/h9-12,14-15H,6-8,16H2,1-5H3,(H,30,35)	XTKTUVLINMHVGS-UHFFFAOYSA-N	794621	US20260062387, Example 152	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794621&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606017	528826084							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126158	CCOCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C28H30N6O3/c1-6-37-8-7-34-15-20(14-31-34)17-9-19(13-29)24-22(11-17)32-33(4)26(24)18-10-21-25(23(12-18)36-5)27(35)30-16-28(21,2)3/h9-12,14-15H,6-8,16H2,1-5H3,(H,30,35)	XTKTUVLINMHVGS-UHFFFAOYSA-N	794621	US20260062387, Example 152	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794621&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606017	528826084							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126159	CCOCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C28H30N6O3/c1-6-37-8-7-34-15-20(14-31-34)17-9-19(13-29)24-22(11-17)32-33(4)26(24)18-10-21-25(23(12-18)36-5)27(35)30-16-28(21,2)3/h9-12,14-15H,6-8,16H2,1-5H3,(H,30,35)	XTKTUVLINMHVGS-UHFFFAOYSA-N	794621	US20260062387, Example 152	Serine/threonine-protein kinase SIK3	Homo sapiens		 14.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794621&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606017	528826084							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126160	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H24F4N6O4/c1-13(38)11-37-12-17(10-33-37)14-4-16(9-32)22-18(5-14)35-36(2)24(22)15-6-19(40-3)23(20(7-15)41-26(28)29)25(39)34-21-8-27(21,30)31/h4-7,10,12-13,21,26,38H,8,11H2,1-3H3,(H,34,39)	ZDUOHIZFTKAUFZ-UHFFFAOYSA-N	794622	US20260062387, Example 153	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794622&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605959	528826085							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126161	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H24F4N6O4/c1-13(38)11-37-12-17(10-33-37)14-4-16(9-32)22-18(5-14)35-36(2)24(22)15-6-19(40-3)23(20(7-15)41-26(28)29)25(39)34-21-8-27(21,30)31/h4-7,10,12-13,21,26,38H,8,11H2,1-3H3,(H,34,39)	ZDUOHIZFTKAUFZ-UHFFFAOYSA-N	794622	US20260062387, Example 153	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794622&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605959	528826085							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126162	COc1cc(-c2c3c(C#N)cc(-c4cnn(C[C@@H](C)O)c4)cc3nn2C)cc(OC(F)F)c1C(=O)N[C@@H]1CC1(F)F	InChI=1S/C27H24F4N6O4/c1-13(38)11-37-12-17(10-33-37)14-4-16(9-32)22-18(5-14)35-36(2)24(22)15-6-19(40-3)23(20(7-15)41-26(28)29)25(39)34-21-8-27(21,30)31/h4-7,10,12-13,21,26,38H,8,11H2,1-3H3,(H,34,39)	ZDUOHIZFTKAUFZ-UHFFFAOYSA-N	794622	US20260062387, Example 153	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794622&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605959	528826085							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126163	COCCn1cc(-c2cc(OC(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H23F4N5O5/c1-32-21(13-8-16(36-3)20(22(29)34)18(9-13)38-24(27)28)19-15(31-32)6-12(7-17(19)37-23(25)26)14-10-30-33(11-14)4-5-35-2/h6-11,23-24H,4-5H2,1-3H3,(H2,29,34)	YZYORZWKFSNEBZ-UHFFFAOYSA-N	794623	US20260062387, Example 154	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794623&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606072	528826086							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126164	COCCn1cc(-c2cc(OC(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H23F4N5O5/c1-32-21(13-8-16(36-3)20(22(29)34)18(9-13)38-24(27)28)19-15(31-32)6-12(7-17(19)37-23(25)26)14-10-30-33(11-14)4-5-35-2/h6-11,23-24H,4-5H2,1-3H3,(H2,29,34)	YZYORZWKFSNEBZ-UHFFFAOYSA-N	794623	US20260062387, Example 154	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794623&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606072	528826086							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126165	COCCn1cc(-c2cc(OC(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C24H23F4N5O5/c1-32-21(13-8-16(36-3)20(22(29)34)18(9-13)38-24(27)28)19-15(31-32)6-12(7-17(19)37-23(25)26)14-10-30-33(11-14)4-5-35-2/h6-11,23-24H,4-5H2,1-3H3,(H2,29,34)	YZYORZWKFSNEBZ-UHFFFAOYSA-N	794623	US20260062387, Example 154	Serine/threonine-protein kinase SIK3	Homo sapiens		 9.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794623&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606072	528826086							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126166	CCn1cc(-c2cc(OC(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C23H21F4N5O4/c1-4-32-10-13(9-29-32)11-5-14-18(16(6-11)35-22(24)25)20(31(2)30-14)12-7-15(34-3)19(21(28)33)17(8-12)36-23(26)27/h5-10,22-23H,4H2,1-3H3,(H2,28,33)	FHFNYUAVHAEKEC-UHFFFAOYSA-N	794624	US20260062387, Example 155	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794624&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606019	528826087							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126167	CCn1cc(-c2cc(OC(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C23H21F4N5O4/c1-4-32-10-13(9-29-32)11-5-14-18(16(6-11)35-22(24)25)20(31(2)30-14)12-7-15(34-3)19(21(28)33)17(8-12)36-23(26)27/h5-10,22-23H,4H2,1-3H3,(H2,28,33)	FHFNYUAVHAEKEC-UHFFFAOYSA-N	794624	US20260062387, Example 155	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794624&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606019	528826087							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126168	CCn1cc(-c2cc(OC(F)F)c3c(-c4cc(OC)c(C(N)=O)c(OC(F)F)c4)n(C)nc3c2)cn1	InChI=1S/C23H21F4N5O4/c1-4-32-10-13(9-29-32)11-5-14-18(16(6-11)35-22(24)25)20(31(2)30-14)12-7-15(34-3)19(21(28)33)17(8-12)36-23(26)27/h5-10,22-23H,4H2,1-3H3,(H2,28,33)	FHFNYUAVHAEKEC-UHFFFAOYSA-N	794624	US20260062387, Example 155	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794624&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606019	528826087							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126169	COc1cc(-c2c3c(OCC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H21F4N5O4/c1-31-9-13(8-29-31)11-4-14-19(16(5-11)35-10-18(24)25)21(32(2)30-14)12-6-15(34-3)20(22(28)33)17(7-12)36-23(26)27/h4-9,18,23H,10H2,1-3H3,(H2,28,33)	CYMCFTSRXQAYGZ-UHFFFAOYSA-N	794625	US20260062387, Example 156	Serine/threonine-protein kinase SIK1	Homo sapiens		 4.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794625&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606216	528826088							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126170	COc1cc(-c2c3c(OCC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H21F4N5O4/c1-31-9-13(8-29-31)11-4-14-19(16(5-11)35-10-18(24)25)21(32(2)30-14)12-6-15(34-3)20(22(28)33)17(7-12)36-23(26)27/h4-9,18,23H,10H2,1-3H3,(H2,28,33)	CYMCFTSRXQAYGZ-UHFFFAOYSA-N	794625	US20260062387, Example 156	Serine/threonine-protein kinase SIK2	Homo sapiens		 0.700							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794625&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606216	528826088							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126171	COc1cc(-c2c3c(OCC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H21F4N5O4/c1-31-9-13(8-29-31)11-4-14-19(16(5-11)35-10-18(24)25)21(32(2)30-14)12-6-15(34-3)20(22(28)33)17(7-12)36-23(26)27/h4-9,18,23H,10H2,1-3H3,(H2,28,33)	CYMCFTSRXQAYGZ-UHFFFAOYSA-N	794625	US20260062387, Example 156	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794625&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606216	528826088							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126172	COc1cc(-c2c3c(OCC(F)(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H20F5N5O4/c1-32-9-13(8-30-32)11-4-14-18(16(5-11)36-10-23(26,27)28)20(33(2)31-14)12-6-15(35-3)19(21(29)34)17(7-12)37-22(24)25/h4-9,22H,10H2,1-3H3,(H2,29,34)	CUPOBBPJHUCONW-UHFFFAOYSA-N	794626	US20260062387, Example 157	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794626&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606153	528826089							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126173	COc1cc(-c2c3c(OCC(F)(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H20F5N5O4/c1-32-9-13(8-30-32)11-4-14-18(16(5-11)36-10-23(26,27)28)20(33(2)31-14)12-6-15(35-3)19(21(29)34)17(7-12)37-22(24)25/h4-9,22H,10H2,1-3H3,(H2,29,34)	CUPOBBPJHUCONW-UHFFFAOYSA-N	794626	US20260062387, Example 157	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.000							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794626&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606153	528826089							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126174	COc1cc(-c2c3c(OCC(F)(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C23H20F5N5O4/c1-32-9-13(8-30-32)11-4-14-18(16(5-11)36-10-23(26,27)28)20(33(2)31-14)12-6-15(35-3)19(21(29)34)17(7-12)37-22(24)25/h4-9,22H,10H2,1-3H3,(H2,29,34)	CUPOBBPJHUCONW-UHFFFAOYSA-N	794626	US20260062387, Example 157	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794626&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606153	528826089							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126175	COc1cc(-c2c3c(C(F)F)cc(-c4cnn([C@H]5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H23F4N5O4/c1-33-22(13-7-18(36-2)21(24(30)35)19(8-13)38-25(28)29)20-16(23(26)27)5-12(6-17(20)32-33)14-9-31-34(10-14)15-3-4-37-11-15/h5-10,15,23,25H,3-4,11H2,1-2H3,(H2,30,35)	PFQONHBMPMVNAB-UHFFFAOYSA-N	794627	US20260062387, Example 158	Serine/threonine-protein kinase SIK1	Homo sapiens		 11.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794627&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606223	528826090							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126176	COc1cc(-c2c3c(C(F)F)cc(-c4cnn([C@H]5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H23F4N5O4/c1-33-22(13-7-18(36-2)21(24(30)35)19(8-13)38-25(28)29)20-16(23(26)27)5-12(6-17(20)32-33)14-9-31-34(10-14)15-3-4-37-11-15/h5-10,15,23,25H,3-4,11H2,1-2H3,(H2,30,35)	PFQONHBMPMVNAB-UHFFFAOYSA-N	794627	US20260062387, Example 158	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794627&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606223	528826090							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126177	COc1cc(-c2c3c(C(F)F)cc(-c4cnn([C@H]5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H23F4N5O4/c1-33-22(13-7-18(36-2)21(24(30)35)19(8-13)38-25(28)29)20-16(23(26)27)5-12(6-17(20)32-33)14-9-31-34(10-14)15-3-4-37-11-15/h5-10,15,23,25H,3-4,11H2,1-2H3,(H2,30,35)	PFQONHBMPMVNAB-UHFFFAOYSA-N	794627	US20260062387, Example 158	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794627&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606223	528826090							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126178	COc1cc(-c2c3c(C(F)F)cc(-c4cnn([C@@H]5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H23F4N5O4/c1-33-22(13-7-18(36-2)21(24(30)35)19(8-13)38-25(28)29)20-16(23(26)27)5-12(6-17(20)32-33)14-9-31-34(10-14)15-3-4-37-11-15/h5-10,15,23,25H,3-4,11H2,1-2H3,(H2,30,35)	PFQONHBMPMVNAB-UHFFFAOYSA-N	794628	US20260062387, Example 159	Serine/threonine-protein kinase SIK1	Homo sapiens		 13.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794628&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606217	528826091							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126179	COc1cc(-c2c3c(C(F)F)cc(-c4cnn([C@@H]5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H23F4N5O4/c1-33-22(13-7-18(36-2)21(24(30)35)19(8-13)38-25(28)29)20-16(23(26)27)5-12(6-17(20)32-33)14-9-31-34(10-14)15-3-4-37-11-15/h5-10,15,23,25H,3-4,11H2,1-2H3,(H2,30,35)	PFQONHBMPMVNAB-UHFFFAOYSA-N	794628	US20260062387, Example 159	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794628&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606217	528826091							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126180	COc1cc(-c2c3c(C(F)F)cc(-c4cnn([C@@H]5CCOC5)c4)cc3nn2C)cc(OC(F)F)c1C(N)=O	InChI=1S/C25H23F4N5O4/c1-33-22(13-7-18(36-2)21(24(30)35)19(8-13)38-25(28)29)20-16(23(26)27)5-12(6-17(20)32-33)14-9-31-34(10-14)15-3-4-37-11-15/h5-10,15,23,25H,3-4,11H2,1-2H3,(H2,30,35)	PFQONHBMPMVNAB-UHFFFAOYSA-N	794628	US20260062387, Example 159	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794628&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606217	528826091							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126181	CC1CNC(=O)c2c(OC(F)F)cc(-c3c4c(C#N)cc(-c5cnn(C)c5)cc4nn3C)cc21	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-24(25)26)22-20-15(8-27)4-13(6-18(20)30-32(22)3)16-10-29-31(2)11-16/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	FRXBRMCXQLCEQI-UHFFFAOYSA-N	794629	US20260062387, Example 160	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794629&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606102	528826092							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126182	CC1CNC(=O)c2c(OC(F)F)cc(-c3c4c(C#N)cc(-c5cnn(C)c5)cc4nn3C)cc21	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-24(25)26)22-20-15(8-27)4-13(6-18(20)30-32(22)3)16-10-29-31(2)11-16/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	FRXBRMCXQLCEQI-UHFFFAOYSA-N	794629	US20260062387, Example 160	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.000							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794629&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606102	528826092							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126183	CC1CNC(=O)c2c(OC(F)F)cc(-c3c4c(C#N)cc(-c5cnn(C)c5)cc4nn3C)cc21	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-24(25)26)22-20-15(8-27)4-13(6-18(20)30-32(22)3)16-10-29-31(2)11-16/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	FRXBRMCXQLCEQI-UHFFFAOYSA-N	794629	US20260062387, Example 160	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794629&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606102	528826092							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126184	COc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)C(C)CNC4=O)c12	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-19(20)34-24(25)26)22-21-17(29-31(22)3)6-13(7-18(21)33-4)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	LSGCFSZLQAHORW-UHFFFAOYSA-N	794630	US20260062387, Example 161	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794630&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606117	528826093							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126185	COc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)C(C)CNC4=O)c12	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-19(20)34-24(25)26)22-21-17(29-31(22)3)6-13(7-18(21)33-4)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	LSGCFSZLQAHORW-UHFFFAOYSA-N	794630	US20260062387, Example 161	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794630&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606117	528826093							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126186	COc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)C(C)CNC4=O)c12	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-19(20)34-24(25)26)22-21-17(29-31(22)3)6-13(7-18(21)33-4)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	LSGCFSZLQAHORW-UHFFFAOYSA-N	794630	US20260062387, Example 161	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794630&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606117	528826093							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126187	Cn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H22F2N6O2/c1-25(2)12-29-23(34)21-17(25)6-14(8-19(21)35-24(26)27)22-20-15(9-28)5-13(7-18(20)31-33(22)4)16-10-30-32(3)11-16/h5-8,10-11,24H,12H2,1-4H3,(H,29,34)	HAQUOXCQIUAHIM-UHFFFAOYSA-N	794631	US20260062387, Example 162	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794631&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605927	528826094							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126188	Cn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H22F2N6O2/c1-25(2)12-29-23(34)21-17(25)6-14(8-19(21)35-24(26)27)22-20-15(9-28)5-13(7-18(20)31-33(22)4)16-10-30-32(3)11-16/h5-8,10-11,24H,12H2,1-4H3,(H,29,34)	HAQUOXCQIUAHIM-UHFFFAOYSA-N	794631	US20260062387, Example 162	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794631&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605927	528826094							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126189	Cn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)C(C)(C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H22F2N6O2/c1-25(2)12-29-23(34)21-17(25)6-14(8-19(21)35-24(26)27)22-20-15(9-28)5-13(7-18(20)31-33(22)4)16-10-30-32(3)11-16/h5-8,10-11,24H,12H2,1-4H3,(H,29,34)	HAQUOXCQIUAHIM-UHFFFAOYSA-N	794631	US20260062387, Example 162	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794631&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605927	528826094							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126190	CCOc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C25H27N5O3/c1-6-33-21-9-15(17-12-27-29(3)13-17)8-19-23(21)24(30(4)28-19)16-7-18-14(2)11-26-25(31)22(18)20(10-16)32-5/h7-10,12-14H,6,11H2,1-5H3,(H,26,31)	CICAIZSYZBWJSL-UHFFFAOYSA-N	794632	US20260062387, Example 163	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794632&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606232	528826095							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126191	CCOc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C25H27N5O3/c1-6-33-21-9-15(17-12-27-29(3)13-17)8-19-23(21)24(30(4)28-19)16-7-18-14(2)11-26-25(31)22(18)20(10-16)32-5/h7-10,12-14H,6,11H2,1-5H3,(H,26,31)	CICAIZSYZBWJSL-UHFFFAOYSA-N	794632	US20260062387, Example 163	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794632&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606232	528826095							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126192	CCOc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C25H27N5O3/c1-6-33-21-9-15(17-12-27-29(3)13-17)8-19-23(21)24(30(4)28-19)16-7-18-14(2)11-26-25(31)22(18)20(10-16)32-5/h7-10,12-14H,6,11H2,1-5H3,(H,26,31)	CICAIZSYZBWJSL-UHFFFAOYSA-N	794632	US20260062387, Example 163	Serine/threonine-protein kinase SIK3	Homo sapiens		 11.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794632&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606232	528826095							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126193	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-18(20)33-4)22-21-17(29-31(22)3)6-13(7-19(21)34-24(25)26)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	FETKEGCFLFOCST-UHFFFAOYSA-N	794633	US20260062387, Example 164	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794633&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606106	528826096							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126194	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-18(20)33-4)22-21-17(29-31(22)3)6-13(7-19(21)34-24(25)26)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	FETKEGCFLFOCST-UHFFFAOYSA-N	794633	US20260062387, Example 164	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794633&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606106	528826096							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126195	COc1cc(-c2c3c(OC(F)F)cc(-c4cnn(C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-18(20)33-4)22-21-17(29-31(22)3)6-13(7-19(21)34-24(25)26)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	FETKEGCFLFOCST-UHFFFAOYSA-N	794633	US20260062387, Example 164	Serine/threonine-protein kinase SIK3	Homo sapiens		 19.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794633&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606106	528826096							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126196	COc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-19(20)34-24(25)26)22-21-17(29-31(22)3)6-13(7-18(21)33-4)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	LSGCFSZLQAHORW-UHFFFAOYSA-N	794634	US20260062387, Example 165	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794634&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606078	528826097							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126197	COc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-19(20)34-24(25)26)22-21-17(29-31(22)3)6-13(7-18(21)33-4)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	LSGCFSZLQAHORW-UHFFFAOYSA-N	794634	US20260062387, Example 165	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794634&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606078	528826097							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126198	COc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-19(20)34-24(25)26)22-21-17(29-31(22)3)6-13(7-18(21)33-4)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	LSGCFSZLQAHORW-UHFFFAOYSA-N	794634	US20260062387, Example 165	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794634&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606078	528826097							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126199	COc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-19(20)34-24(25)26)22-21-17(29-31(22)3)6-13(7-18(21)33-4)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	LSGCFSZLQAHORW-UHFFFAOYSA-N	794635	US20260062387, Example 166	Serine/threonine-protein kinase SIK1	Homo sapiens		 11.9							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794635&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606078	528826098							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126200	COc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-19(20)34-24(25)26)22-21-17(29-31(22)3)6-13(7-18(21)33-4)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	LSGCFSZLQAHORW-UHFFFAOYSA-N	794635	US20260062387, Example 166	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794635&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606078	528826098							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126201	COc1cc(-c2cnn(C)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C24H23F2N5O3/c1-12-9-27-23(32)20-16(12)5-14(8-19(20)34-24(25)26)22-21-17(29-31(22)3)6-13(7-18(21)33-4)15-10-28-30(2)11-15/h5-8,10-12,24H,9H2,1-4H3,(H,27,32)	LSGCFSZLQAHORW-UHFFFAOYSA-N	794635	US20260062387, Example 166	Serine/threonine-protein kinase SIK3	Homo sapiens		 9.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794635&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606078	528826098							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126202	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C26H26N6O2/c1-14(2)32-13-19(12-29-32)16-6-18(10-27)23-21(8-16)30-31(4)25(23)17-7-20-15(3)11-28-26(33)24(20)22(9-17)34-5/h6-9,12-15H,11H2,1-5H3,(H,28,33)	CQTZFQOEKWECNO-UHFFFAOYSA-N	794636	US20260062387, Example 167	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794636&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606086	528826099							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126203	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C26H26N6O2/c1-14(2)32-13-19(12-29-32)16-6-18(10-27)23-21(8-16)30-31(4)25(23)17-7-20-15(3)11-28-26(33)24(20)22(9-17)34-5/h6-9,12-15H,11H2,1-5H3,(H,28,33)	CQTZFQOEKWECNO-UHFFFAOYSA-N	794636	US20260062387, Example 167	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794636&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606086	528826099							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126204	COc1cc(-c2c3c(C#N)cc(-c4cnn(C(C)C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C26H26N6O2/c1-14(2)32-13-19(12-29-32)16-6-18(10-27)23-21(8-16)30-31(4)25(23)17-7-20-15(3)11-28-26(33)24(20)22(9-17)34-5/h6-9,12-15H,11H2,1-5H3,(H,28,33)	CQTZFQOEKWECNO-UHFFFAOYSA-N	794636	US20260062387, Example 167	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794636&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606086	528826099							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126205	CCCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C27H28N6O2/c1-5-6-7-33-15-20(14-30-33)17-8-19(12-28)24-22(10-17)31-32(3)26(24)18-9-21-16(2)13-29-27(34)25(21)23(11-18)35-4/h8-11,14-16H,5-7,13H2,1-4H3,(H,29,34)	ILSZRIWMYYVXHW-UHFFFAOYSA-N	794637	US20260062387, Example 168	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794637&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606211	528826100							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126206	CCCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C27H28N6O2/c1-5-6-7-33-15-20(14-30-33)17-8-19(12-28)24-22(10-17)31-32(3)26(24)18-9-21-16(2)13-29-27(34)25(21)23(11-18)35-4/h8-11,14-16H,5-7,13H2,1-4H3,(H,29,34)	ILSZRIWMYYVXHW-UHFFFAOYSA-N	794637	US20260062387, Example 168	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794637&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606211	528826100							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126207	CCCCn1cc(-c2cc(C#N)c3c(-c4cc(OC)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C27H28N6O2/c1-5-6-7-33-15-20(14-30-33)17-8-19(12-28)24-22(10-17)31-32(3)26(24)18-9-21-16(2)13-29-27(34)25(21)23(11-18)35-4/h8-11,14-16H,5-7,13H2,1-4H3,(H,29,34)	ILSZRIWMYYVXHW-UHFFFAOYSA-N	794637	US20260062387, Example 168	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794637&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606211	528826100							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126208	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C27H28N6O2/c1-15(2)13-33-14-20(12-30-33)17-6-19(10-28)24-22(8-17)31-32(4)26(24)18-7-21-16(3)11-29-27(34)25(21)23(9-18)35-5/h6-9,12,14-16H,11,13H2,1-5H3,(H,29,34)	QXDFZAJBROIPPF-UHFFFAOYSA-N	794638	US20260062387, Example 169	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794638&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605992	528826101							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126209	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C27H28N6O2/c1-15(2)13-33-14-20(12-30-33)17-6-19(10-28)24-22(8-17)31-32(4)26(24)18-7-21-16(3)11-29-27(34)25(21)23(9-18)35-5/h6-9,12,14-16H,11,13H2,1-5H3,(H,29,34)	QXDFZAJBROIPPF-UHFFFAOYSA-N	794638	US20260062387, Example 169	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794638&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605992	528826101							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126210	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC(C)C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C27H28N6O2/c1-15(2)13-33-14-20(12-30-33)17-6-19(10-28)24-22(8-17)31-32(4)26(24)18-7-21-16(3)11-29-27(34)25(21)23(9-18)35-5/h6-9,12,14-16H,11,13H2,1-5H3,(H,29,34)	QXDFZAJBROIPPF-UHFFFAOYSA-N	794638	US20260062387, Example 169	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794638&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605992	528826101							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126211	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CC5)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C27H26N6O2/c1-15-11-29-27(34)25-21(15)7-18(9-23(25)35-3)26-24-19(10-28)6-17(8-22(24)31-32(26)2)20-12-30-33(14-20)13-16-4-5-16/h6-9,12,14-16H,4-5,11,13H2,1-3H3,(H,29,34)	DQRVBYLOPFJETL-UHFFFAOYSA-N	794639	US20260062387, Example 170	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794639&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606081	528826102							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126212	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CC5)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C27H26N6O2/c1-15-11-29-27(34)25-21(15)7-18(9-23(25)35-3)26-24-19(10-28)6-17(8-22(24)31-32(26)2)20-12-30-33(14-20)13-16-4-5-16/h6-9,12,14-16H,4-5,11,13H2,1-3H3,(H,29,34)	DQRVBYLOPFJETL-UHFFFAOYSA-N	794639	US20260062387, Example 170	Serine/threonine-protein kinase SIK2	Homo sapiens		 1.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794639&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606081	528826102							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126213	COc1cc(-c2c3c(C#N)cc(-c4cnn(CC5CC5)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C27H26N6O2/c1-15-11-29-27(34)25-21(15)7-18(9-23(25)35-3)26-24-19(10-28)6-17(8-22(24)31-32(26)2)20-12-30-33(14-20)13-16-4-5-16/h6-9,12,14-16H,4-5,11,13H2,1-3H3,(H,29,34)	DQRVBYLOPFJETL-UHFFFAOYSA-N	794639	US20260062387, Example 170	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794639&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606081	528826102							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126214	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C28H30N6O2/c1-16(2)6-7-34-15-21(14-31-34)18-8-20(12-29)25-23(10-18)32-33(4)27(25)19-9-22-17(3)13-30-28(35)26(22)24(11-19)36-5/h8-11,14-17H,6-7,13H2,1-5H3,(H,30,35)	SVSIBPBAVWALTL-UHFFFAOYSA-N	794640	US20260062387, Example 171	Serine/threonine-protein kinase SIK1	Homo sapiens		 9.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794640&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606182	528826103							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126215	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C28H30N6O2/c1-16(2)6-7-34-15-21(14-31-34)18-8-20(12-29)25-23(10-18)32-33(4)27(25)19-9-22-17(3)13-30-28(35)26(22)24(11-19)36-5/h8-11,14-17H,6-7,13H2,1-5H3,(H,30,35)	SVSIBPBAVWALTL-UHFFFAOYSA-N	794640	US20260062387, Example 171	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794640&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606182	528826103							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126216	COc1cc(-c2c3c(C#N)cc(-c4cnn(CCC(C)C)c4)cc3nn2C)cc2c1C(=O)NC[C@@H]2C	InChI=1S/C28H30N6O2/c1-16(2)6-7-34-15-21(14-31-34)18-8-20(12-29)25-23(10-18)32-33(4)27(25)19-9-22-17(3)13-30-28(35)26(22)24(11-19)36-5/h8-11,14-17H,6-7,13H2,1-5H3,(H,30,35)	SVSIBPBAVWALTL-UHFFFAOYSA-N	794640	US20260062387, Example 171	Serine/threonine-protein kinase SIK3	Homo sapiens		 4.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794640&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606182	528826103							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126217	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H24F2N6O3/c1-14-11-30-25(35)23-19(14)7-16(9-21(23)37-26(27)28)24-22-17(10-29)6-15(8-20(22)32-33(24)2)18-12-31-34(13-18)4-5-36-3/h6-9,12-14,26H,4-5,11H2,1-3H3,(H,30,35)	HDCLVHHBSWVXNZ-UHFFFAOYSA-N	794641	US20260062387, Example 172	Serine/threonine-protein kinase SIK1	Homo sapiens		 19.5							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794641&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605943	528826104							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126218	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H24F2N6O3/c1-14-11-30-25(35)23-19(14)7-16(9-21(23)37-26(27)28)24-22-17(10-29)6-15(8-20(22)32-33(24)2)18-12-31-34(13-18)4-5-36-3/h6-9,12-14,26H,4-5,11H2,1-3H3,(H,30,35)	HDCLVHHBSWVXNZ-UHFFFAOYSA-N	794641	US20260062387, Example 172	Serine/threonine-protein kinase SIK2	Homo sapiens		 7.80							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794641&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605943	528826104							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126219	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H24F2N6O3/c1-14-11-30-25(35)23-19(14)7-16(9-21(23)37-26(27)28)24-22-17(10-29)6-15(8-20(22)32-33(24)2)18-12-31-34(13-18)4-5-36-3/h6-9,12-14,26H,4-5,11H2,1-3H3,(H,30,35)	HDCLVHHBSWVXNZ-UHFFFAOYSA-N	794641	US20260062387, Example 172	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794641&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605943	528826104							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126220	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H24F2N6O3/c1-14-11-30-25(35)23-19(14)7-16(9-21(23)37-26(27)28)24-22-17(10-29)6-15(8-20(22)32-33(24)2)18-12-31-34(13-18)4-5-36-3/h6-9,12-14,26H,4-5,11H2,1-3H3,(H,30,35)	HDCLVHHBSWVXNZ-UHFFFAOYSA-N	794642	US20260062387, Example 173	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794642&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172605943	528826105							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126221	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H24F2N6O3/c1-14-11-30-25(35)23-19(14)7-16(9-21(23)37-26(27)28)24-22-17(10-29)6-15(8-20(22)32-33(24)2)18-12-31-34(13-18)4-5-36-3/h6-9,12-14,26H,4-5,11H2,1-3H3,(H,30,35)	HDCLVHHBSWVXNZ-UHFFFAOYSA-N	794642	US20260062387, Example 173	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794642&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172605943	528826105							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126222	COCCn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H24F2N6O3/c1-14-11-30-25(35)23-19(14)7-16(9-21(23)37-26(27)28)24-22-17(10-29)6-15(8-20(22)32-33(24)2)18-12-31-34(13-18)4-5-36-3/h6-9,12-14,26H,4-5,11H2,1-3H3,(H,30,35)	HDCLVHHBSWVXNZ-UHFFFAOYSA-N	794642	US20260062387, Example 173	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794642&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172605943	528826105							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126223	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H22F2N6O2/c1-4-33-12-17(11-30-33)14-5-16(9-28)21-19(7-14)31-32(3)23(21)15-6-18-13(2)10-29-24(34)22(18)20(8-15)35-25(26)27/h5-8,11-13,25H,4,10H2,1-3H3,(H,29,34)	UXHSZJZASCJRKH-UHFFFAOYSA-N	794643	US20260062387, Example 174	Serine/threonine-protein kinase SIK1	Homo sapiens		 8.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794643&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606022	528826106							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126224	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H22F2N6O2/c1-4-33-12-17(11-30-33)14-5-16(9-28)21-19(7-14)31-32(3)23(21)15-6-18-13(2)10-29-24(34)22(18)20(8-15)35-25(26)27/h5-8,11-13,25H,4,10H2,1-3H3,(H,29,34)	UXHSZJZASCJRKH-UHFFFAOYSA-N	794643	US20260062387, Example 174	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.30							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794643&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606022	528826106							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126225	CCn1cc(-c2cc(C#N)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H22F2N6O2/c1-4-33-12-17(11-30-33)14-5-16(9-28)21-19(7-14)31-32(3)23(21)15-6-18-13(2)10-29-24(34)22(18)20(8-15)35-25(26)27/h5-8,11-13,25H,4,10H2,1-3H3,(H,29,34)	UXHSZJZASCJRKH-UHFFFAOYSA-N	794643	US20260062387, Example 174	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.60							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794643&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606022	528826106							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126226	COc1cc(-c2cnn(C[C@H](C)O)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C26H27F2N5O4/c1-13-9-29-25(35)22-18(13)5-16(8-21(22)37-26(27)28)24-23-19(31-32(24)3)6-15(7-20(23)36-4)17-10-30-33(12-17)11-14(2)34/h5-8,10,12-14,26,34H,9,11H2,1-4H3,(H,29,35)	UCVSQDNZMCHWFW-UHFFFAOYSA-N	794644	US20260062387, Example 175	Serine/threonine-protein kinase SIK1	Homo sapiens		 7.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794644&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606152	528826107							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126227	COc1cc(-c2cnn(C[C@H](C)O)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C26H27F2N5O4/c1-13-9-29-25(35)22-18(13)5-16(8-21(22)37-26(27)28)24-23-19(31-32(24)3)6-15(7-20(23)36-4)17-10-30-33(12-17)11-14(2)34/h5-8,10,12-14,26,34H,9,11H2,1-4H3,(H,29,35)	UCVSQDNZMCHWFW-UHFFFAOYSA-N	794644	US20260062387, Example 175	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794644&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606152	528826107							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126228	COc1cc(-c2cnn(C[C@H](C)O)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C26H27F2N5O4/c1-13-9-29-25(35)22-18(13)5-16(8-21(22)37-26(27)28)24-23-19(31-32(24)3)6-15(7-20(23)36-4)17-10-30-33(12-17)11-14(2)34/h5-8,10,12-14,26,34H,9,11H2,1-4H3,(H,29,35)	UCVSQDNZMCHWFW-UHFFFAOYSA-N	794644	US20260062387, Example 175	Serine/threonine-protein kinase SIK3	Homo sapiens		 7.20							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794644&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606152	528826107							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126229	COc1cc(-c2cnn(C[C@H](C)O)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C26H27F2N5O4/c1-13-9-29-25(35)22-18(13)5-16(8-21(22)37-26(27)28)24-23-19(31-32(24)3)6-15(7-20(23)36-4)17-10-30-33(12-17)11-14(2)34/h5-8,10,12-14,26,34H,9,11H2,1-4H3,(H,29,35)	UCVSQDNZMCHWFW-UHFFFAOYSA-N	794645	US20260062387, Example 176	Serine/threonine-protein kinase SIK1	Homo sapiens		 11.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794645&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606152	528826108							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126230	COc1cc(-c2cnn(C[C@H](C)O)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C26H27F2N5O4/c1-13-9-29-25(35)22-18(13)5-16(8-21(22)37-26(27)28)24-23-19(31-32(24)3)6-15(7-20(23)36-4)17-10-30-33(12-17)11-14(2)34/h5-8,10,12-14,26,34H,9,11H2,1-4H3,(H,29,35)	UCVSQDNZMCHWFW-UHFFFAOYSA-N	794645	US20260062387, Example 176	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.90							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794645&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606152	528826108							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126231	COc1cc(-c2cnn(C[C@H](C)O)c2)cc2nn(C)c(-c3cc(OC(F)F)c4c(c3)[C@@H](C)CNC4=O)c12	InChI=1S/C26H27F2N5O4/c1-13-9-29-25(35)22-18(13)5-16(8-21(22)37-26(27)28)24-23-19(31-32(24)3)6-15(7-20(23)36-4)17-10-30-33(12-17)11-14(2)34/h5-8,10,12-14,26,34H,9,11H2,1-4H3,(H,29,35)	UCVSQDNZMCHWFW-UHFFFAOYSA-N	794645	US20260062387, Example 176	Serine/threonine-protein kinase SIK3	Homo sapiens		 11.9							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794645&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606152	528826108							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126232	COCCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H27F2N5O4/c1-14-11-29-25(34)22-18(14)7-16(10-21(22)37-26(27)28)24-23-19(31-32(24)2)8-15(9-20(23)36-4)17-12-30-33(13-17)5-6-35-3/h7-10,12-14,26H,5-6,11H2,1-4H3,(H,29,34)	ITBSNECRNRCJST-UHFFFAOYSA-N	794646	US20260062387, Example 177	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794646&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606158	528826109							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126233	COCCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H27F2N5O4/c1-14-11-29-25(34)22-18(14)7-16(10-21(22)37-26(27)28)24-23-19(31-32(24)2)8-15(9-20(23)36-4)17-12-30-33(13-17)5-6-35-3/h7-10,12-14,26H,5-6,11H2,1-4H3,(H,29,34)	ITBSNECRNRCJST-UHFFFAOYSA-N	794646	US20260062387, Example 177	Serine/threonine-protein kinase SIK2	Homo sapiens		 3.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794646&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606158	528826109							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126234	COCCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H27F2N5O4/c1-14-11-29-25(34)22-18(14)7-16(10-21(22)37-26(27)28)24-23-19(31-32(24)2)8-15(9-20(23)36-4)17-12-30-33(13-17)5-6-35-3/h7-10,12-14,26H,5-6,11H2,1-4H3,(H,29,34)	ITBSNECRNRCJST-UHFFFAOYSA-N	794646	US20260062387, Example 177	Serine/threonine-protein kinase SIK3	Homo sapiens		 10.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794646&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606158	528826109							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126235	COCCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H27F2N5O4/c1-14-11-29-25(34)22-18(14)7-16(10-21(22)37-26(27)28)24-23-19(31-32(24)2)8-15(9-20(23)36-4)17-12-30-33(13-17)5-6-35-3/h7-10,12-14,26H,5-6,11H2,1-4H3,(H,29,34)	ITBSNECRNRCJST-UHFFFAOYSA-N	794647	US20260062387, Example 178	Serine/threonine-protein kinase SIK1	Homo sapiens		 10.1							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794647&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606158	528826110							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126236	COCCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H27F2N5O4/c1-14-11-29-25(34)22-18(14)7-16(10-21(22)37-26(27)28)24-23-19(31-32(24)2)8-15(9-20(23)36-4)17-12-30-33(13-17)5-6-35-3/h7-10,12-14,26H,5-6,11H2,1-4H3,(H,29,34)	ITBSNECRNRCJST-UHFFFAOYSA-N	794647	US20260062387, Example 178	Serine/threonine-protein kinase SIK2	Homo sapiens		 4.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794647&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606158	528826110							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126237	COCCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C26H27F2N5O4/c1-14-11-29-25(34)22-18(14)7-16(10-21(22)37-26(27)28)24-23-19(31-32(24)2)8-15(9-20(23)36-4)17-12-30-33(13-17)5-6-35-3/h7-10,12-14,26H,5-6,11H2,1-4H3,(H,29,34)	ITBSNECRNRCJST-UHFFFAOYSA-N	794647	US20260062387, Example 178	Serine/threonine-protein kinase SIK3	Homo sapiens		 15.6							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794647&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606158	528826110							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126238	CCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H25F2N5O3/c1-5-32-12-16(11-29-32)14-7-18-22(19(8-14)34-4)23(31(3)30-18)15-6-17-13(2)10-28-24(33)21(17)20(9-15)35-25(26)27/h6-9,11-13,25H,5,10H2,1-4H3,(H,28,33)	ANEXRCBEMWWANC-UHFFFAOYSA-N	794648	US20260062387, Example 179	Serine/threonine-protein kinase SIK1	Homo sapiens		 5.70							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794648&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606160	528826111							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126239	CCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H25F2N5O3/c1-5-32-12-16(11-29-32)14-7-18-22(19(8-14)34-4)23(31(3)30-18)15-6-17-13(2)10-28-24(33)21(17)20(9-15)35-25(26)27/h6-9,11-13,25H,5,10H2,1-4H3,(H,28,33)	ANEXRCBEMWWANC-UHFFFAOYSA-N	794648	US20260062387, Example 179	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794648&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606160	528826111							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126240	CCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H25F2N5O3/c1-5-32-12-16(11-29-32)14-7-18-22(19(8-14)34-4)23(31(3)30-18)15-6-17-13(2)10-28-24(33)21(17)20(9-15)35-25(26)27/h6-9,11-13,25H,5,10H2,1-4H3,(H,28,33)	ANEXRCBEMWWANC-UHFFFAOYSA-N	794648	US20260062387, Example 179	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794648&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606160	528826111							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126241	CCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H25F2N5O3/c1-5-32-12-16(11-29-32)14-7-18-22(19(8-14)34-4)23(31(3)30-18)15-6-17-13(2)10-28-24(33)21(17)20(9-15)35-25(26)27/h6-9,11-13,25H,5,10H2,1-4H3,(H,28,33)	ANEXRCBEMWWANC-UHFFFAOYSA-N	794649	US20260062387, Example 180	Serine/threonine-protein kinase SIK1	Homo sapiens		 13.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794649&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606160	528826112							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126242	CCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H25F2N5O3/c1-5-32-12-16(11-29-32)14-7-18-22(19(8-14)34-4)23(31(3)30-18)15-6-17-13(2)10-28-24(33)21(17)20(9-15)35-25(26)27/h6-9,11-13,25H,5,10H2,1-4H3,(H,28,33)	ANEXRCBEMWWANC-UHFFFAOYSA-N	794649	US20260062387, Example 180	Serine/threonine-protein kinase SIK2	Homo sapiens		 5.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794649&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606160	528826112							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126243	CCn1cc(-c2cc(OC)c3c(-c4cc(OC(F)F)c5c(c4)[C@@H](C)CNC5=O)n(C)nc3c2)cn1	InChI=1S/C25H25F2N5O3/c1-5-32-12-16(11-29-32)14-7-18-22(19(8-14)34-4)23(31(3)30-18)15-6-17-13(2)10-28-24(33)21(17)20(9-15)35-25(26)27/h6-9,11-13,25H,5,10H2,1-4H3,(H,28,33)	ANEXRCBEMWWANC-UHFFFAOYSA-N	794649	US20260062387, Example 180	Serine/threonine-protein kinase SIK3	Homo sapiens		 12.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794649&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606160	528826112							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126244	C[C@H]1CNC(=O)c2c(OC(F)F)cc(-c3c4c(C#N)cc(-c5cnn(C)c5)cc4nn3C)cc21	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-24(25)26)22-20-15(8-27)4-13(6-18(20)30-32(22)3)16-10-29-31(2)11-16/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	FRXBRMCXQLCEQI-UHFFFAOYSA-N	794650	US20260062387, Example 181	Serine/threonine-protein kinase SIK1	Homo sapiens		 19.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794650&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606090	528826113							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126245	C[C@H]1CNC(=O)c2c(OC(F)F)cc(-c3c4c(C#N)cc(-c5cnn(C)c5)cc4nn3C)cc21	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-24(25)26)22-20-15(8-27)4-13(6-18(20)30-32(22)3)16-10-29-31(2)11-16/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	FRXBRMCXQLCEQI-UHFFFAOYSA-N	794650	US20260062387, Example 181	Serine/threonine-protein kinase SIK2	Homo sapiens		 6.10							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794650&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606090	528826113							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126246	C[C@H]1CNC(=O)c2c(OC(F)F)cc(-c3c4c(C#N)cc(-c5cnn(C)c5)cc4nn3C)cc21	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-24(25)26)22-20-15(8-27)4-13(6-18(20)30-32(22)3)16-10-29-31(2)11-16/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	FRXBRMCXQLCEQI-UHFFFAOYSA-N	794650	US20260062387, Example 181	Serine/threonine-protein kinase SIK3	Homo sapiens		 3.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794650&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606090	528826113							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126247	C[C@H]1CNC(=O)c2c(OC(F)F)cc(-c3c4c(C#N)cc(-c5cnn(C)c5)cc4nn3C)cc21	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-24(25)26)22-20-15(8-27)4-13(6-18(20)30-32(22)3)16-10-29-31(2)11-16/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	FRXBRMCXQLCEQI-UHFFFAOYSA-N	794651	US20260062387, Example 182	Serine/threonine-protein kinase SIK1	Homo sapiens		 6.40							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794651&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			172606090	528826114							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126248	C[C@H]1CNC(=O)c2c(OC(F)F)cc(-c3c4c(C#N)cc(-c5cnn(C)c5)cc4nn3C)cc21	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-24(25)26)22-20-15(8-27)4-13(6-18(20)30-32(22)3)16-10-29-31(2)11-16/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	FRXBRMCXQLCEQI-UHFFFAOYSA-N	794651	US20260062387, Example 182	Serine/threonine-protein kinase SIK2	Homo sapiens		 2.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794651&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			172606090	528826114							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126249	C[C@H]1CNC(=O)c2c(OC(F)F)cc(-c3c4c(C#N)cc(-c5cnn(C)c5)cc4nn3C)cc21	InChI=1S/C24H20F2N6O2/c1-12-9-28-23(33)21-17(12)5-14(7-19(21)34-24(25)26)22-20-15(8-27)4-13(6-18(20)30-32(22)3)16-10-29-31(2)11-16/h4-7,10-12,24H,9H2,1-3H3,(H,28,33)	FRXBRMCXQLCEQI-UHFFFAOYSA-N	794651	US20260062387, Example 182	Serine/threonine-protein kinase SIK3	Homo sapiens		 2.00							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794651&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			172606090	528826114							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126250	COc1cc(cc(OC(F)F)c1C(=O)NC1CC1)-n1cnc2cc(ccc12)-c1cnn(C)c1	InChI=1S/C23H21F2N5O3/c1-29-11-14(10-27-29)13-3-6-18-17(7-13)26-12-30(18)16-8-19(32-2)21(20(9-16)33-23(24)25)22(31)28-15-4-5-15/h3,6-12,15,23H,4-5H2,1-2H3,(H,28,31)	PFTXFNSHFZLJNT-UHFFFAOYSA-N	50621264	CHEMBL5417444::US20260062387, Comparative Example 1	Serine/threonine-protein kinase SIK1	Homo sapiens		 146							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621264&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search											1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126251	COc1cc(cc(OC(F)F)c1C(=O)NC1CC1)-n1cnc2cc(ccc12)-c1cnn(C)c1	InChI=1S/C23H21F2N5O3/c1-29-11-14(10-27-29)13-3-6-18-17(7-13)26-12-30(18)16-8-19(32-2)21(20(9-16)33-23(24)25)22(31)28-15-4-5-15/h3,6-12,15,23H,4-5H2,1-2H3,(H,28,31)	PFTXFNSHFZLJNT-UHFFFAOYSA-N	50621264	CHEMBL5417444::US20260062387, Comparative Example 1	Serine/threonine-protein kinase SIK2	Homo sapiens		 10.8							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621264&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search											1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126252	COc1cc(cc(OC(F)F)c1C(=O)NC1CC1)-n1cnc2cc(ccc12)-c1cnn(C)c1	InChI=1S/C23H21F2N5O3/c1-29-11-14(10-27-29)13-3-6-18-17(7-13)26-12-30(18)16-8-19(32-2)21(20(9-16)33-23(24)25)22(31)28-15-4-5-15/h3,6-12,15,23H,4-5H2,1-2H3,(H,28,31)	PFTXFNSHFZLJNT-UHFFFAOYSA-N	50621264	CHEMBL5417444::US20260062387, Comparative Example 1	Serine/threonine-protein kinase SIK3	Homo sapiens		 5.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621264&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search											1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126253	COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC)c1C(=O)NCC(F)F	InChI=1S/C22H21F2N5O3/c1-28-11-14(9-27-28)13-4-5-17-16(6-13)26-12-29(17)15-7-18(31-2)21(19(8-15)32-3)22(30)25-10-20(23)24/h4-9,11-12,20H,10H2,1-3H3,(H,25,30)	WRDZOEPVIKBBON-UHFFFAOYSA-N	794653	N-(2,2-difluoroethyl)-2,6-dimethoxy-4-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]benzamide::US20260062387, Comparative Example 2	Serine/threonine-protein kinase SIK1	Homo sapiens		 1004							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794653&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			152309891	528826116							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126254	COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC)c1C(=O)NCC(F)F	InChI=1S/C22H21F2N5O3/c1-28-11-14(9-27-28)13-4-5-17-16(6-13)26-12-29(17)15-7-18(31-2)21(19(8-15)32-3)22(30)25-10-20(23)24/h4-9,11-12,20H,10H2,1-3H3,(H,25,30)	WRDZOEPVIKBBON-UHFFFAOYSA-N	794653	N-(2,2-difluoroethyl)-2,6-dimethoxy-4-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]benzamide::US20260062387, Comparative Example 2	Serine/threonine-protein kinase SIK2	Homo sapiens		 86.4							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794653&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			152309891	528826116							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126255	COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC)c1C(=O)NCC(F)F	InChI=1S/C22H21F2N5O3/c1-28-11-14(9-27-28)13-4-5-17-16(6-13)26-12-29(17)15-7-18(31-2)21(19(8-15)32-3)22(30)25-10-20(23)24/h4-9,11-12,20H,10H2,1-3H3,(H,25,30)	WRDZOEPVIKBBON-UHFFFAOYSA-N	794653	N-(2,2-difluoroethyl)-2,6-dimethoxy-4-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]benzamide::US20260062387, Comparative Example 2	Serine/threonine-protein kinase SIK3	Homo sapiens		 39.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794653&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			152309891	528826116							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126256	COc1cc(-c2cnc3cc(-c4cnn(C)c4)ccn23)cc2c1C(=O)N(C1CC1)CC2	InChI=1S/C24H23N5O2/c1-27-14-18(12-26-27)15-5-8-29-20(13-25-22(29)11-15)17-9-16-6-7-28(19-3-4-19)24(30)23(16)21(10-17)31-2/h5,8-14,19H,3-4,6-7H2,1-2H3	BVNPDJCOAFIFNY-UHFFFAOYSA-N	794654	2-cyclopropyl-8-methoxy-6-[7-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-3,4-dihydroisoquinolin-1-one::US20260062387, Comparative Example 3	Serine/threonine-protein kinase SIK1	Homo sapiens		 398							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794654&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			154636426	528826117							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126257	COc1cc(-c2cnc3cc(-c4cnn(C)c4)ccn23)cc2c1C(=O)N(C1CC1)CC2	InChI=1S/C24H23N5O2/c1-27-14-18(12-26-27)15-5-8-29-20(13-25-22(29)11-15)17-9-16-6-7-28(19-3-4-19)24(30)23(16)21(10-17)31-2/h5,8-14,19H,3-4,6-7H2,1-2H3	BVNPDJCOAFIFNY-UHFFFAOYSA-N	794654	2-cyclopropyl-8-methoxy-6-[7-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-3,4-dihydroisoquinolin-1-one::US20260062387, Comparative Example 3	Serine/threonine-protein kinase SIK2	Homo sapiens		 22.7							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794654&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			154636426	528826117							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126258	COc1cc(-c2cnc3cc(-c4cnn(C)c4)ccn23)cc2c1C(=O)N(C1CC1)CC2	InChI=1S/C24H23N5O2/c1-27-14-18(12-26-27)15-5-8-29-20(13-25-22(29)11-15)17-9-16-6-7-28(19-3-4-19)24(30)23(16)21(10-17)31-2/h5,8-14,19H,3-4,6-7H2,1-2H3	BVNPDJCOAFIFNY-UHFFFAOYSA-N	794654	2-cyclopropyl-8-methoxy-6-[7-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-3,4-dihydroisoquinolin-1-one::US20260062387, Comparative Example 3	Serine/threonine-protein kinase SIK3	Homo sapiens		 6.50							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794654&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			154636426	528826117							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126259	COc1cc(cc2CCN(CC(F)(F)F)C(=O)c12)-c1cnc2cc(OCCN3CCOCC3)ccn12	InChI=1S/C25H27F3N4O4/c1-34-21-13-18(12-17-2-4-31(16-25(26,27)28)24(33)23(17)21)20-15-29-22-14-19(3-5-32(20)22)36-11-8-30-6-9-35-10-7-30/h3,5,12-15H,2,4,6-11,16H2,1H3	XASOHFCUIQARJT-UHFFFAOYSA-N	50618894	CHEMBL5393771::US20260062387, Comparative Example 4	Serine/threonine-protein kinase SIK1	Homo sapiens		 7914							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50618894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50618894&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			146273261	505051872							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126260	COc1cc(cc2CCN(CC(F)(F)F)C(=O)c12)-c1cnc2cc(OCCN3CCOCC3)ccn12	InChI=1S/C25H27F3N4O4/c1-34-21-13-18(12-17-2-4-31(16-25(26,27)28)24(33)23(17)21)20-15-29-22-14-19(3-5-32(20)22)36-11-8-30-6-9-35-10-7-30/h3,5,12-15H,2,4,6-11,16H2,1H3	XASOHFCUIQARJT-UHFFFAOYSA-N	50618894	CHEMBL5393771::US20260062387, Comparative Example 4	Serine/threonine-protein kinase SIK2	Homo sapiens		 287							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50618894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50618894&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			146273261	505051872							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126261	COc1cc(cc2CCN(CC(F)(F)F)C(=O)c12)-c1cnc2cc(OCCN3CCOCC3)ccn12	InChI=1S/C25H27F3N4O4/c1-34-21-13-18(12-17-2-4-31(16-25(26,27)28)24(33)23(17)21)20-15-29-22-14-19(3-5-32(20)22)36-11-8-30-6-9-35-10-7-30/h3,5,12-15H,2,4,6-11,16H2,1H3	XASOHFCUIQARJT-UHFFFAOYSA-N	50618894	CHEMBL5393771::US20260062387, Comparative Example 4	Serine/threonine-protein kinase SIK3	Homo sapiens		 75.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50618894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50618894&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			146273261	505051872							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126262	COc1cc(-c2cnn3cc(C(C)(C)C#N)ccc23)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C23H21F3N4O3/c1-23(2,11-27)13-4-5-17-14(9-28-30(17)10-13)12-6-18(32-3)20(19(7-12)33-22(25)26)21(31)29-16-8-15(16)24/h4-7,9-10,15-16,22H,8H2,1-3H3,(H,29,31)	BDTLFPRHEXLZDV-UHFFFAOYSA-N	794656	4-[6-(1-cyano-1-methyl-ethyl)pyrazolo[1,5-a]pyridin-3-yl]-2-(difluoromethoxy)-N-[(1R,2S)-2-fluorocyclopropyl]-6-methoxy-benzamide::US20260062387, Comparative Example 5	Serine/threonine-protein kinase SIK1	Homo sapiens		>10000							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794656&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			155727246	528826119							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126263	COc1cc(-c2cnn3cc(C(C)(C)C#N)ccc23)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C23H21F3N4O3/c1-23(2,11-27)13-4-5-17-14(9-28-30(17)10-13)12-6-18(32-3)20(19(7-12)33-22(25)26)21(31)29-16-8-15(16)24/h4-7,9-10,15-16,22H,8H2,1-3H3,(H,29,31)	BDTLFPRHEXLZDV-UHFFFAOYSA-N	794656	4-[6-(1-cyano-1-methyl-ethyl)pyrazolo[1,5-a]pyridin-3-yl]-2-(difluoromethoxy)-N-[(1R,2S)-2-fluorocyclopropyl]-6-methoxy-benzamide::US20260062387, Comparative Example 5	Serine/threonine-protein kinase SIK2	Homo sapiens		 5482							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794656&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			155727246	528826119							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126264	COc1cc(-c2cnn3cc(C(C)(C)C#N)ccc23)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F	InChI=1S/C23H21F3N4O3/c1-23(2,11-27)13-4-5-17-14(9-28-30(17)10-13)12-6-18(32-3)20(19(7-12)33-22(25)26)21(31)29-16-8-15(16)24/h4-7,9-10,15-16,22H,8H2,1-3H3,(H,29,31)	BDTLFPRHEXLZDV-UHFFFAOYSA-N	794656	4-[6-(1-cyano-1-methyl-ethyl)pyrazolo[1,5-a]pyridin-3-yl]-2-(difluoromethoxy)-N-[(1R,2S)-2-fluorocyclopropyl]-6-methoxy-benzamide::US20260062387, Comparative Example 5	Serine/threonine-protein kinase SIK3	Homo sapiens		 52.2							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794656&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			155727246	528826119							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126265	COc1cc(-c2cnn3cc(OCCN4CCOCC4)ccc23)cc2c1C(=O)N(CC(F)(F)F)CC2	InChI=1S/C25H27F3N4O4/c1-34-22-13-18(12-17-4-5-31(16-25(26,27)28)24(33)23(17)22)20-14-29-32-15-19(2-3-21(20)32)36-11-8-30-6-9-35-10-7-30/h2-3,12-15H,4-11,16H2,1H3	OYZURSFQUYCTIJ-UHFFFAOYSA-N	794657	8-methoxy-6-[6-(2-morpholinoethoxy)pyrazolo[1,5-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1-one::US20260062387, Comparative Example 6	Serine/threonine-protein kinase SIK1	Homo sapiens		 5224							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794657&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			155339981	528826120							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126266	COc1cc(-c2cnn3cc(OCCN4CCOCC4)ccc23)cc2c1C(=O)N(CC(F)(F)F)CC2	InChI=1S/C25H27F3N4O4/c1-34-22-13-18(12-17-4-5-31(16-25(26,27)28)24(33)23(17)22)20-14-29-32-15-19(2-3-21(20)32)36-11-8-30-6-9-35-10-7-30/h2-3,12-15H,4-11,16H2,1H3	OYZURSFQUYCTIJ-UHFFFAOYSA-N	794657	8-methoxy-6-[6-(2-morpholinoethoxy)pyrazolo[1,5-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1-one::US20260062387, Comparative Example 6	Serine/threonine-protein kinase SIK2	Homo sapiens		 102							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794657&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			155339981	528826120							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126267	COc1cc(-c2cnn3cc(OCCN4CCOCC4)ccc23)cc2c1C(=O)N(CC(F)(F)F)CC2	InChI=1S/C25H27F3N4O4/c1-34-22-13-18(12-17-4-5-31(16-25(26,27)28)24(33)23(17)22)20-14-29-32-15-19(2-3-21(20)32)36-11-8-30-6-9-35-10-7-30/h2-3,12-15H,4-11,16H2,1H3	OYZURSFQUYCTIJ-UHFFFAOYSA-N	794657	8-methoxy-6-[6-(2-morpholinoethoxy)pyrazolo[1,5-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1-one::US20260062387, Comparative Example 6	Serine/threonine-protein kinase SIK3	Homo sapiens		 42.0							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794657&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			155339981	528826120							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126268	COc1cc(-c2c3ccc(OCCN4CCOCC4)cc3nn2C)cc(OC(F)F)c1C(=O)NC1CC1	InChI=1S/C26H30F2N4O5/c1-31-24(19-6-5-18(15-20(19)30-31)36-12-9-32-7-10-35-11-8-32)16-13-21(34-2)23(22(14-16)37-26(27)28)25(33)29-17-3-4-17/h5-6,13-15,17,26H,3-4,7-12H2,1-2H3,(H,29,33)	PXQKLMPQAWLTMB-UHFFFAOYSA-N	794658	N-cyclopropyl-2-(difluoromethoxy)-6-methoxy-4-(2-methyl-6-(2-morpholinoethoxy)-2H-indazol-3-yl)benzamide::US20260062387, Comparative Example 7	Serine/threonine-protein kinase SIK1	Homo sapiens		 7601							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794658&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			166520793	528826121							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126269	COc1cc(-c2c3ccc(OCCN4CCOCC4)cc3nn2C)cc(OC(F)F)c1C(=O)NC1CC1	InChI=1S/C26H30F2N4O5/c1-31-24(19-6-5-18(15-20(19)30-31)36-12-9-32-7-10-35-11-8-32)16-13-21(34-2)23(22(14-16)37-26(27)28)25(33)29-17-3-4-17/h5-6,13-15,17,26H,3-4,7-12H2,1-2H3,(H,29,33)	PXQKLMPQAWLTMB-UHFFFAOYSA-N	794658	N-cyclopropyl-2-(difluoromethoxy)-6-methoxy-4-(2-methyl-6-(2-morpholinoethoxy)-2H-indazol-3-yl)benzamide::US20260062387, Comparative Example 7	Serine/threonine-protein kinase SIK2	Homo sapiens		 369							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794658&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			166520793	528826121							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126270	COc1cc(-c2c3ccc(OCCN4CCOCC4)cc3nn2C)cc(OC(F)F)c1C(=O)NC1CC1	InChI=1S/C26H30F2N4O5/c1-31-24(19-6-5-18(15-20(19)30-31)36-12-9-32-7-10-35-11-8-32)16-13-21(34-2)23(22(14-16)37-26(27)28)25(33)29-17-3-4-17/h5-6,13-15,17,26H,3-4,7-12H2,1-2H3,(H,29,33)	PXQKLMPQAWLTMB-UHFFFAOYSA-N	794658	N-cyclopropyl-2-(difluoromethoxy)-6-methoxy-4-(2-methyl-6-(2-morpholinoethoxy)-2H-indazol-3-yl)benzamide::US20260062387, Comparative Example 7	Serine/threonine-protein kinase SIK3	Homo sapiens		 198							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794658&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			166520793	528826121							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126271	COc1cc(-c2c3ccc(N4CCN(C)CC4)cc3nn2C)cc2c1C(=O)N(CC(F)(F)F)CC2	InChI=1S/C25H28F3N5O2/c1-30-8-10-32(11-9-30)18-4-5-19-20(14-18)29-31(2)23(19)17-12-16-6-7-33(15-25(26,27)28)24(34)22(16)21(13-17)35-3/h4-5,12-14H,6-11,15H2,1-3H3	NWUKYJSLFJTZPN-UHFFFAOYSA-N	794659	8-methoxy-6-(2-methyl-6-(4-methylpiperazin-1-yl)-2H-indazol-3-yl)-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1(2H)-one::US20260062387, Comparative Example 8	Serine/threonine-protein kinase SIK1	Homo sapiens		>10000							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004173&target=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794659&enzyme=Serine%2Fthreonine-protein+kinase+SIK1&column=ki&startPg=0&Increment=50&submit=Search			166520790	528826122							1	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ		Serine/threonine-protein kinase SIK1	SIK1_HUMAN	P57059	A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126272	COc1cc(-c2c3ccc(N4CCN(C)CC4)cc3nn2C)cc2c1C(=O)N(CC(F)(F)F)CC2	InChI=1S/C25H28F3N5O2/c1-30-8-10-32(11-9-30)18-4-5-19-20(14-18)29-31(2)23(19)17-12-16-6-7-33(15-25(26,27)28)24(34)22(16)21(13-17)35-3/h4-5,12-14H,6-11,15H2,1-3H3	NWUKYJSLFJTZPN-UHFFFAOYSA-N	794659	8-methoxy-6-(2-methyl-6-(4-methylpiperazin-1-yl)-2H-indazol-3-yl)-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1(2H)-one::US20260062387, Comparative Example 8	Serine/threonine-protein kinase SIK2	Homo sapiens		 683							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8138&target=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794659&enzyme=Serine%2Fthreonine-protein+kinase+SIK2&column=ki&startPg=0&Increment=50&submit=Search			166520790	528826122							1	MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN		Serine/threonine-protein kinase SIK2	SIK2_HUMAN	Q9H0K1	A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
126273	COc1cc(-c2c3ccc(N4CCN(C)CC4)cc3nn2C)cc2c1C(=O)N(CC(F)(F)F)CC2	InChI=1S/C25H28F3N5O2/c1-30-8-10-32(11-9-30)18-4-5-19-20(14-18)29-31(2)23(19)17-12-16-6-7-33(15-25(26,27)28)24(34)22(16)21(13-17)35-3/h4-5,12-14H,6-11,15H2,1-3H3	NWUKYJSLFJTZPN-UHFFFAOYSA-N	794659	8-methoxy-6-(2-methyl-6-(4-methylpiperazin-1-yl)-2H-indazol-3-yl)-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1(2H)-one::US20260062387, Comparative Example 8	Serine/threonine-protein kinase SIK3	Homo sapiens		 887							US Patent		10.7270/Q2V98F1B			US20260062387	NAKAJIMA, M; SHITAMA, H; ARAI, Y; NAKATAKE, D; MIYAZAKI, H; KODA, Y	9/13/2013	8/8/2014	Mitsubishi Tanabe Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000376&target=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794659&enzyme=Serine%2Fthreonine-protein+kinase+SIK3&column=ki&startPg=0&Increment=50&submit=Search			166520790	528826122							1	MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV		Serine/threonine-protein kinase SIK3	SIK3_HUMAN	Q9Y2K2	A1A5A8 H0Y494 J3KPC8 Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50