BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
1071568	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C15H12ClN3O/c1-17-14-12-8-7-10(16)9-13(12)19(15(20)18-14)11-5-3-2-4-6-11/h2-9H,1H3,(H,17,18,20)	KTFNCXUTCFGSLS-UHFFFAOYSA-N	507716	US11046691, Compound 2::7-chloro-4-(methylamino)-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 2	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507716&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150866826	459092801							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071569	CN(C)c1nc(=O)n(-c2ccc(F)cc2)c2cc(Cl)ccc12	InChI=1S/C16H13ClFN3O/c1-20(2)15-13-8-3-10(17)9-14(13)21(16(22)19-15)12-6-4-11(18)5-7-12/h3-9H,1-2H3	ULAPMWYVKFSLCX-UHFFFAOYSA-N	507717	US11130759, Cpd. No. 36::US11046691, Compound 36::4-(dimethylamino)-7-chloro-1-(4- fluorophenyl)-hydroquinazolin-2-one::US11084798, Cpd No 36	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507717&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152022594	459092802							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071570	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(OC)c12	InChI=1S/C16H14ClN3O2/c1-18-15-14-12(8-10(17)9-13(14)22-2)20(16(21)19-15)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,18,19,21)	AADSUVGVTWJPDU-UHFFFAOYSA-N	507718	US11130759, Cpd. No. 70::US11046691, Compound 70::7-chloro-5-methoxy-4-(methylamino)- 1-phenylquinazolin-2(1H)-one::US11084798, Cpd No 70	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507718&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608334	459092803							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071571	CNc1nc(=O)n(-c2ccccc2)c2cc(Br)ccc12	InChI=1S/C15H12BrN3O/c1-17-14-12-8-7-10(16)9-13(12)19(15(20)18-14)11-5-3-2-4-6-11/h2-9H,1H3,(H,17,18,20)	BQAUXAXKAMVXGY-UHFFFAOYSA-N	507719	US11130759, Cpd. No. 3::US11046691, Compound 3::7-bromo-4-(methylamino)-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 3	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507719&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608598	459092804							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071572	CN(C)c1nc(=O)n(-c2cc(O)cc(F)c2)c2cc(Cl)ccc12	InChI=1S/C16H13ClFN3O2/c1-20(2)15-13-4-3-9(17)5-14(13)21(16(23)19-15)11-6-10(18)7-12(22)8-11/h3-8,22H,1-2H3	ONLSJQVRCAMFJT-UHFFFAOYSA-N	507720	US11130759, Cpd. No. 37::US11046691, Compound 37::4-(dimethylamino)-7-chloro-1-(5- fluoro-3-hydroxyphenyl)hydro- quinazolin-2-one::US11084798, Cpd No 37	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507720&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608770	459092805							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071573	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)c(OC)cc12	InChI=1S/C16H14ClN3O2/c1-18-15-11-8-14(22-2)12(17)9-13(11)20(16(21)19-15)10-6-4-3-5-7-10/h3-9H,1-2H3,(H,18,19,21)	ZWPOFMLNEXRXMO-UHFFFAOYSA-N	507721	US11130759, Cpd. No. 73::US11046691, Compound 73::7-chloro-6-methoxy-4-(methylamino)- 1-phenylquinazolin-2(1H)-one::US11084798, Cpd No 73	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507721&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608436	459092806							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071574	CNc1nc(=O)n(-c2ccccc2)c2cc(F)ccc12	InChI=1S/C15H12FN3O/c1-17-14-12-8-7-10(16)9-13(12)19(15(20)18-14)11-5-3-2-4-6-11/h2-9H,1H3,(H,17,18,20)	DGOJOOORKUDPMY-UHFFFAOYSA-N	507722	US11130759, Cpd. No. 4::US11046691, Compound 4::7-fluoro-1-phenylquinazolin-2(1H)-one::US11084798, Cpd No 4	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507722&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150027587	459092807							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071575	Oc1cc(F)cc(c1)-n1c2cc(Cl)ccc2c(nc1=O)N1CCC1	InChI=1S/C17H13ClFN3O2/c18-10-2-3-14-15(6-10)22(12-7-11(19)8-13(23)9-12)17(24)20-16(14)21-4-1-5-21/h2-3,6-9,23H,1,4-5H2	TYOKKSFYUUWVPQ-UHFFFAOYSA-N	507723	US11130759, Cpd. No. 38::US11046691, Compound 38::4-azetidinyl-7-chloro-1-(5-fluoro-3- hydroxy-phenyl)hydroquinazolin-2-one::US11084798, Cpd No 38	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507723&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151960570	459092808							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071576	OC1CN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C17H14ClN3O2/c18-11-6-7-14-15(8-11)21(12-4-2-1-3-5-12)17(23)19-16(14)20-9-13(22)10-20/h1-8,13,22H,9-10H2	OEQNMMYLZGSHSO-UHFFFAOYSA-N	507724	US11130759, Cpd. No. 74::US11046691, Compound 74::7-chloro-4-(3-hydroxyazetidin-1-yl)-1- phenylquinazolin-2(1H)-one::US11084798, Cpd No 74	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507724&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151312103	459092809							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071577	CNc1nc(=O)n(-c2cc(O)cc(F)c2)c2cc(Cl)ccc12	InChI=1S/C15H11ClFN3O2/c1-18-14-12-3-2-8(16)4-13(12)20(15(22)19-14)10-5-9(17)6-11(21)7-10/h2-7,21H,1H3,(H,18,19,22)	VWYYGOBKZXVBCC-UHFFFAOYSA-N	507725	US11130759, Cpd. No. 5::US11046691, Compound 5::7-Chloro-1-(5-fluoro-3-hydroxy- phenyl)-4-(methylamino)- hydroquinazolin-2-one::US11084798, Cpd No 5	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507725&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152209617	459092810							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071578	CN(C1CC1)c1nc(=O)n(-c2cccc(F)c2)c2cc(Cl)ccc12	InChI=1S/C18H15ClFN3O/c1-22(13-6-7-13)17-15-8-5-11(19)9-16(15)23(18(24)21-17)14-4-2-3-12(20)10-14/h2-5,8-10,13H,6-7H2,1H3	FKCNNJYOVSNYFQ-UHFFFAOYSA-N	507726	US11130759, Cpd. No. 39::US11046691, Compound 39::7-chloro-4-(cyclopropylmethylamino)- 1-(3-fluorophenyl)hydroquinazolin-2- one::US11084798, Cpd No 39	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507726&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150174446	459092811							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071579	CN(C)c1nc(=O)n(-c2cccc(CCOc3ccccc3)c2)c2cc(Cl)ccc12	InChI=1S/C24H22ClN3O2/c1-27(2)23-21-12-11-18(25)16-22(21)28(24(29)26-23)19-8-6-7-17(15-19)13-14-30-20-9-4-3-5-10-20/h3-12,15-16H,13-14H2,1-2H3	KNLMLIOJDAILGD-UHFFFAOYSA-N	507727	US11130759, Cpd. No. 75::US11046691, Compound 75::7-chloro-4-(dimethylamino)-1-(3-(2- phenoxyethyl)phenyl)quinazolin-2(1H)- one::US11084798, Cpd No 75	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507727&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150838322	459092812							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071580	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)c(F)cc12	InChI=1S/C15H11ClFN3O/c1-18-14-10-7-12(17)11(16)8-13(10)20(15(21)19-14)9-5-3-2-4-6-9/h2-8H,1H3,(H,18,19,21)	XRXJAGXLMAOFJY-UHFFFAOYSA-N	507728	US11130759, Cpd. No. 6::US11046691, Compound 6::7-chloro-6-fluoro-4-(methylamino)-1- phenyl-quinazolin-2(1H)-one::US11084798, Cpd No 6	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507728&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152443211	459092813							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071581	CN(C)c1nc(=O)n(-c2ccccc2)c2c(Cl)c(Cl)ccc12	InChI=1S/C16H13Cl2N3O/c1-20(2)15-11-8-9-12(17)13(18)14(11)21(16(22)19-15)10-6-4-3-5-7-10/h3-9H,1-2H3	UYGCCIKOLVRUID-UHFFFAOYSA-N	507729	US11130759, Cpd. No. 42::US11046691, Compound 42::7,8-dichloro-4-(dimethylamino)-1- phenylquinazolin-2(1H)-one::US11084798, Cpd No 42	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507729&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152088743	459092814							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071582	COc1cccc(c1)-n1c2cc(Cl)ccc2c(nc1=O)N(C)C	InChI=1S/C17H16ClN3O2/c1-20(2)16-14-8-7-11(18)9-15(14)21(17(22)19-16)12-5-4-6-13(10-12)23-3/h4-10H,1-3H3	JPTGTHMGGQGHSO-UHFFFAOYSA-N	507730	US11130759, Cpd. No. 76::US11046691, Compound 76::4-(dimethylamino)-7-chloro-1-(3- methoxyphenyphydroquinazolin-2-one::US11084798, Cpd No 76	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507730&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148102774	459092815							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071583	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(F)c12	InChI=1S/C15H11ClFN3O/c1-18-14-13-11(17)7-9(16)8-12(13)20(15(21)19-14)10-5-3-2-4-6-10/h2-8H,1H3,(H,18,19,21)	AGJHEWJPRFUWQJ-UHFFFAOYSA-N	507731	US11130759, Cpd. No. 7::US11046691, Compound 7::7-chloro-5-fluoro-4-(methylamino)-1- phenyl-quinazolin-2(1H)-one::US11084798, Cpd No 7	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507731&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149637393	459092816							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071584	CN(C)c1nc(=O)n(-c2ccccc2)c2c(C)c(Cl)ccc12	InChI=1S/C17H16ClN3O/c1-11-14(18)10-9-13-15(11)21(12-7-5-4-6-8-12)17(22)19-16(13)20(2)3/h4-10H,1-3H3	PGDYQHAGLSITPK-UHFFFAOYSA-N	507732	US11130759, Cpd. No. 43::US11046691, Compound 43::7-chloro-4-(dimethylamino)-8-methyl- 1-phenyl-quinazolin-2(1H)-one::US11084798, Cpd No 43	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507732&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148897602	459092817							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071585	CN(C)c1nc(=O)n(-c2cccc(CO)c2)c2cc(Cl)ccc12	InChI=1S/C17H16ClN3O2/c1-20(2)16-14-7-6-12(18)9-15(14)21(17(23)19-16)13-5-3-4-11(8-13)10-22/h3-9,22H,10H2,1-2H3	CMQRVLXOAQMQMH-UHFFFAOYSA-N	507733	US11130759, Cpd. No. 77::US11046691, Compound 77::4-(dimethylamino)-7-chloro-1-[3- (hydroxymethyl)phenyllhydroquina- zolin-2-one::US11084798, Cpd No 77	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507733&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608962	459092818							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071586	CNc1nc(=O)n(-c2ccncc2)c2cc(Cl)ccc12	InChI=1S/C14H11ClN4O/c1-16-13-11-3-2-9(15)8-12(11)19(14(20)18-13)10-4-6-17-7-5-10/h2-8H,1H3,(H,16,18,20)	RCPNDUSTPLESEV-UHFFFAOYSA-N	507734	US11130759, Cpd. No. 8::US11046691, Compound 8::7-chloro-4-(methylamino)-1-(pyridin-4- yl)-quinazolin-2(1H)-one::US11084798, Cpd No 8	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507734	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507734&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151691274	459092819							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071587	CNc1nc(=O)n(-c2ccccc2)c2cc(C)ccc12	InChI=1S/C16H15N3O/c1-11-8-9-13-14(10-11)19(12-6-4-3-5-7-12)16(20)18-15(13)17-2/h3-10H,1-2H3,(H,17,18,20)	WZDBUMUAHQWZHB-UHFFFAOYSA-N	507735	US11130759, Cpd. No. 44::US11046691, Compound 44::7-methyl-4-(methylamino)-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 44	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507735	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507735&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152349674	459092820							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071588	c1ccc(cc1)N2c3cc(ccc3C(=NC2=O)N4CC[C@H](C4)F)Cl	InChI=1S/C18H15ClFN3O/c19-12-6-7-15-16(10-12)23(14-4-2-1-3-5-14)18(24)21-17(15)22-9-8-13(20)11-22/h1-7,10,13H,8-9,11H2	GPTUSHRRTGGGTD-UHFFFAOYSA-N	507736	US11130759, Cpd. No. 80::US11046691, Compound 80::(R)-7-chloro-4-(3-fluoropyrrolidin-1- yl)-1-phenylquinazolin-2(1H)-one::US11084798, Cpd No 80	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507736&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	UM6	8P4H	150331522	459092821							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071589	CNc1nc(=O)n(-c2cccnc2)c2cc(Cl)ccc12	InChI=1S/C14H11ClN4O/c1-16-13-11-5-4-9(15)7-12(11)19(14(20)18-13)10-3-2-6-17-8-10/h2-8H,1H3,(H,16,18,20)	KOKAWMZINRQQGS-UHFFFAOYSA-N	507881	US11130759, Cpd. No. 114::US11046691, Compound 114::7-chloro-4-(methylamino)-1-(3- pyridyl)-hydroquinazolin-2-one::US11084798, Cpd No 114	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507881&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148234347	459092965							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071590	CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C1CC1	InChI=1S/C18H17N3O/c1-19-17-15-10-9-13(12-7-8-12)11-16(15)21(18(22)20-17)14-5-3-2-4-6-14/h2-6,9-12H,7-8H2,1H3,(H,19,20,22)	MXEOLZMNHYKRGH-UHFFFAOYSA-N	507738	US11130759, Cpd. No. 45::US11046691, Compound 45::7-cyclopropyl-4-(methylamino)-1- phenylquinazolin-2(1H)-one::US11084798, Cpd No 45	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507738&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151145876	459092823							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071591	CN(C)c1nc(=O)n(-c2cccc(c2)C#N)c2cc(Cl)ccc12	InChI=1S/C17H13ClN4O/c1-21(2)16-14-7-6-12(18)9-15(14)22(17(23)20-16)13-5-3-4-11(8-13)10-19/h3-9H,1-2H3	YJNQZZVHODFIBZ-UHFFFAOYSA-N	507739	US11130759, Cpd. No. 81::US11046691, Compound 81::3-[4-(dimethylamino)-7-chloro-2- oxohydroquinazolinyl]benzenecarbo- nitrile::US11084798, Cpd No 81	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507739&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149369588	459092824							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071592	CNc1nc(=O)n(-c2ncccn2)c2cc(Cl)ccc12	InChI=1S/C13H10ClN5O/c1-15-11-9-4-3-8(14)7-10(9)19(13(20)18-11)12-16-5-2-6-17-12/h2-7H,1H3,(H,15,18,20)	FZNAZQFDVBAIKF-UHFFFAOYSA-N	507740	US11130759, Cpd. No. 11::US11046691, Compound 11::7-chloro-4-(methylamino)-1-pyrimidin- 2-yl-quinazolin-2(1H)-one::US11084798, Cpd No 11	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507740&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147597690	459092825							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071593	CNc1nc(=O)n(-c2cccc(O)c2)c2cc(Cl)ccc12	InChI=1S/C15H12ClN3O2/c1-17-14-12-6-5-9(16)7-13(12)19(15(21)18-14)10-3-2-4-11(20)8-10/h2-8,20H,1H3,(H,17,18,21)	VOFYPKPHVILSKG-UHFFFAOYSA-N	507741	US11130759, Cpd. No. 46::US11046691, Compound 46::7-chloro-1-(3-hydroxyphenyl)-4- (methylamino)-hydroquinazolin-2-one::US11084798, Cpd No 46	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507741&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608682	459092826							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071594	Fc1cccc(c1)-n1c2cc(Cl)ccc2c(nc1=O)N1CC(C1)C#N	InChI=1S/C18H12ClFN4O/c19-12-4-5-15-16(6-12)24(14-3-1-2-13(20)7-14)18(25)22-17(15)23-9-11(8-21)10-23/h1-7,11H,9-10H2	KDUZUFWUAWCHLM-UHFFFAOYSA-N	507742	US11130759, Cpd. No. 82::US11046691, Compound 82::1-(7-chloro-1-(3-fluorophenyl)-2-oxo- 1,2-dihydroquinazolin-4-yl)azetidine-3- carbonitrile::US11084798, Cpd No 82	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507742&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608522	459092827							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071595	CNc1nc(=O)n(-c2cnccn2)c2cc(Cl)ccc12	InChI=1S/C13H10ClN5O/c1-15-12-9-3-2-8(14)6-10(9)19(13(20)18-12)11-7-16-4-5-17-11/h2-7H,1H3,(H,15,18,20)	IBIJQRGHGPDKDB-UHFFFAOYSA-N	507743	US11130759, Cpd. No. 12::US11046691, Compound 12::7-chloro-4-(methylamino)-1-(pyrazin-2- yl)-quinazolin-2(1H)-one::US11084798, Cpd No 12	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507743&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150518539	459092828							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071596	CNc1nc(=O)n(-c2cccc(CCO)c2)c2cc(Cl)ccc12	InChI=1S/C17H16ClN3O2/c1-19-16-14-6-5-12(18)10-15(14)21(17(23)20-16)13-4-2-3-11(9-13)7-8-22/h2-6,9-10,22H,7-8H2,1H3,(H,19,20,23)	BPJHOIAJXACZOT-UHFFFAOYSA-N	507744	US11130759, Cpd. No. 47::US11046691, Compound 47::7-chloro-1-[3-(2-hydroxyethyl)phenyl]- 4-(methylamino)-hydroquinazolin-2- one::US11084798, Cpd No 47	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507744&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608656	459092829							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071597	CNc1nc(=O)n(-c2cncnc2)c2cc(Cl)ccc12	InChI=1S/C13H10ClN5O/c1-15-12-10-3-2-8(14)4-11(10)19(13(20)18-12)9-5-16-7-17-6-9/h2-7H,1H3,(H,15,18,20)	XFJBVRBWTJYRMW-UHFFFAOYSA-N	507745	US11130759, Cpd. No. 14::US11046691, Compound 14::7-chloro-4-(methylamino)-1- (pyrimidin-5-yl)-quinazolin-2(1H)-one::US11084798, Cpd No 14	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507745&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152380846	459092830							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071598	CNc1nc(=O)n(-c2cccc(CCCO)c2)c2cc(Cl)ccc12	InChI=1S/C18H18ClN3O2/c1-20-17-15-8-7-13(19)11-16(15)22(18(24)21-17)14-6-2-4-12(10-14)5-3-9-23/h2,4,6-8,10-11,23H,3,5,9H2,1H3,(H,20,21,24)	KKDUVNZMMAMZHE-UHFFFAOYSA-N	507746	US11130759, Cpd. No. 48::US11046691, Compound 48::7-chloro-1-[3-(3-hydroxypropyl)- phenyl]-4-(methylamino)hydro- quinazolin-2-one::US11084798, Cpd No 48	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507746&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608255	459092831							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071599	CNc1nc(=O)n(-c2cn[nH]c2)c2cc(Cl)ccc12	InChI=1S/C12H10ClN5O/c1-14-11-9-3-2-7(13)4-10(9)18(12(19)17-11)8-5-15-16-6-8/h2-6H,1H3,(H,15,16)(H,14,17,19)	DGNNBRFIPXQZGY-UHFFFAOYSA-N	507747	US11130759, Cpd. No. 15::US11046691, Compound 15::7-chloro-4-(methylamino)-1-(1 H- pyrazol-4-yl)-quinazolin-2(1H)-one::US11084798, Cpd No 15	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507747&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150027425	459092832							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071600	CNc1nc(=O)n(-c2ccccc2)c2cc(OC)ccc12	InChI=1S/C16H15N3O2/c1-17-15-13-9-8-12(21-2)10-14(13)19(16(20)18-15)11-6-4-3-5-7-11/h3-10H,1-2H3,(H,17,18,20)	KLNBUCKDTSMHDP-UHFFFAOYSA-N	507748	US11130759, Cpd. No. 49::US11046691, Compound 49::7-methoxy-4-(methylamino)-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 49	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507748&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608403	459092833							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071601	CNc1nc(=O)n(-c2nccs2)c2cc(Cl)ccc12	InChI=1S/C12H9ClN4OS/c1-14-10-8-3-2-7(13)6-9(8)17(11(18)16-10)12-15-4-5-19-12/h2-6H,1H3,(H,14,16,18)	CDGTUASBLVPTSY-UHFFFAOYSA-N	507749	US11130759, Cpd. No. 17::US11046691, Compound 17::7-chloro-4-(methylamino)-1-(thiazol-2- yl)-quinazolin-2(1H)-one::US11084798, Cpd No 17	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507749&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149881440	459092834							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071602	CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C#N	InChI=1S/C16H12N4O/c1-18-15-13-8-7-11(10-17)9-14(13)20(16(21)19-15)12-5-3-2-4-6-12/h2-9H,1H3,(H,18,19,21)	BTMFXYVNZAESOJ-UHFFFAOYSA-N	507750	US11130759, Cpd. No. 50::US11046691, Compound 50::4-(methylamino)-2-oxo-1-phenyl-1,2- dihydro-quinazoline-7-carbonitrile::US11084798, Cpd No 50	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507750&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608258	459092835							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071603	CNc1nc(=O)n(-c2cncs2)c2cc(Cl)ccc12	InChI=1S/C12H9ClN4OS/c1-14-11-8-3-2-7(13)4-9(8)17(12(18)16-11)10-5-15-6-19-10/h2-6H,1H3,(H,14,16,18)	IBXUZTOIQSTRQP-UHFFFAOYSA-N	507752	US11130759, Cpd. No. 18::US11046691, Compound 18::7-chloro-4-(methylamino)-1-(thiazol-5- yl)-quinazolin-2(1H)-one::US11084798, Cpd No 18	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507752&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150521431	459092837							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071604	CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C16H12F3N3O/c1-20-14-12-8-7-10(16(17,18)19)9-13(12)22(15(23)21-14)11-5-3-2-4-6-11/h2-9H,1H3,(H,20,21,23)	GEKDQWJWACUGHU-UHFFFAOYSA-N	507753	US11130759, Cpd. No. 51::4-(methylamino)-1-phenyl-7-(trifluoro- methyl)-quinazolin-2(1H)-one::US11046691, Compound 369::US11046691, Compound 51::US11084798, Cpd No 51	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507753&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150275149	459092838							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071605	Clc1ccc2c(NC3COC3)nc(=O)n(-c3ccccc3)c2c1	InChI=1S/C17H14ClN3O2/c18-11-6-7-14-15(8-11)21(13-4-2-1-3-5-13)17(22)20-16(14)19-12-9-23-10-12/h1-8,12H,9-10H2,(H,19,20,22)	WZGNHSQFYWBUSY-UHFFFAOYSA-N	507754	US11130759, Cpd. No. 21::US11046691, Compound 21::7-Chloro-4-(oxetan-3-ylamino)-1- phenylquinazolin-2(1H)-one::US11084798, Cpd No 21	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507754&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149172130	459092839							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071606	CN(C)c1nc(=O)n(-c2cccc(NS(C)(=O)=O)c2)c2cc(Cl)ccc12	InChI=1S/C17H17ClN4O3S/c1-21(2)16-14-8-7-11(18)9-15(14)22(17(23)19-16)13-6-4-5-12(10-13)20-26(3,24)25/h4-10,20H,1-3H3	CXBUGMFTSGPIOL-UHFFFAOYSA-N	507757	US11130759, Cpd. No. 52::US11046691, Compound 52::N-(3-(7-chloro-4-(dimethylamino)-2- oxoquinazolin-1 (2H)-yl)phenyl)- methanesulfonamide::US11084798, Cpd No 52	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507757&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608459	459092842							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071607	Clc1ccc2c(N[C@H]3CCOC3)nc(=O)n(-c3ccccc3)c2c1 |r|	InChI=1S/C18H16ClN3O2/c19-12-6-7-15-16(10-12)22(14-4-2-1-3-5-14)18(23)21-17(15)20-13-8-9-24-11-13/h1-7,10,13H,8-9,11H2,(H,20,21,23)	XWUOUSGOABJBRN-UHFFFAOYSA-N	507758	US11130759, Cpd. No. 22::US11046691, Compound 22::(S)-7-chloro-1-phenyl-4-((tetrahydro- furan-3-yl)amino)-quinazolin-2(1H)- one::US11084798, Cpd No 22	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507758&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149301272	459092843							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071608	CN(C)c1nc(=O)n(-c2cccc(O)c2)c2cc(Cl)ccc12	InChI=1S/C16H14ClN3O2/c1-19(2)15-13-7-6-10(17)8-14(13)20(16(22)18-15)11-4-3-5-12(21)9-11/h3-9,21H,1-2H3	OJYPQURAJSUZDS-UHFFFAOYSA-N	507759	US11130759, Cpd. No. 54::US11046691, Compound 54::4-(dimethylamino)-7-chloro-1-(3- hydroxyphenyphydroquinazolin-2- one::US11084798, Cpd No 54	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507759&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608485	459092844							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071609	Clc1ccc2c(NCc3ccccc3)nc(=O)n(-c3ccccc3)c2c1	InChI=1S/C21H16ClN3O/c22-16-11-12-18-19(13-16)25(17-9-5-2-6-10-17)21(26)24-20(18)23-14-15-7-3-1-4-8-15/h1-13H,14H2,(H,23,24,26)	GKGIHUDGVWCACV-UHFFFAOYSA-N	507760	US11130759, Cpd. No. 23::US11046691, Compound 23::4-(benzylamino)-7-chloro-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 23	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507760&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147655114	459092845							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071610	CNc1nc(=O)n(-c2cccc(C)c2)c2cc(Cl)ccc12	InChI=1S/C16H14ClN3O/c1-10-4-3-5-12(8-10)20-14-9-11(17)6-7-13(14)15(18-2)19-16(20)21/h3-9H,1-2H3,(H,18,19,21)	VPFQYHKNUQDINR-UHFFFAOYSA-N	507761	US11130759, Cpd. No. 55::US11046691, Compound 55::7-Chloro-4-(methylamino)-1-(3- methylphenyphydroquinazolin-2- one::US11084798, Cpd No 55	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507761&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608927	459092846							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071611	CN(C)C1=NC(=O)N(c2c1ccc(c2)Cl)c3ccccc3	InChI=1S/C16H14ClN3O/c1-19(2)15-13-9-8-11(17)10-14(13)20(16(21)18-15)12-6-4-3-5-7-12/h3-10H,1-2H3	JMLJEYLWRAPHBL-UHFFFAOYSA-N	507762	US11130759, Cpd. No. 24::US11046691, Compound 24::7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 24	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507762&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	TQB	7BHV	150703860	459092847							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071612	CNc1nc(=O)n(-c2cccc(Cl)c2)c2cc(Cl)ccc12	InChI=1S/C15H11Cl2N3O/c1-18-14-12-6-5-10(17)8-13(12)20(15(21)19-14)11-4-2-3-9(16)7-11/h2-8H,1H3,(H,18,19,21)	BIKSBHVMNZSITB-UHFFFAOYSA-N	507763	US11130759, Cpd. No. 56::US11046691, Compound 56::7-Chloro-1-(3-chlorophenyl)-4- (methylamino)hydroquinazolin-2- one::US11084798, Cpd No 56	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507763&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147089023	459092848							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071613	Clc1ccc2c(nc(=O)n(-c3ccccc3)c2c1)N1CCC1	InChI=1S/C17H14ClN3O/c18-12-7-8-14-15(11-12)21(13-5-2-1-3-6-13)17(22)19-16(14)20-9-4-10-20/h1-3,5-8,11H,4,9-10H2	VIMNRQIBJCCASY-UHFFFAOYSA-N	507764	US11130759, Cpd. No. 25::US11046691, Compound 25::4-(azetidin-1-yl)-7-chloro-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 25	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507764&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152137431	459092849							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071614	CNc1nc(=O)n(-c2ccccc2F)c2cc(Cl)ccc12 |(,5,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.38,;1.33,-.39,;1.33,-1.93,;,-2.69,;,-4.23,;1.33,-5,;2.67,-4.23,;2.67,-2.69,;4,-1.93,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-2.67,1.93,;-1.33,2.69,;,1.92,)|	InChI=1S/C15H11ClFN3O/c1-18-14-10-7-6-9(16)8-13(10)20(15(21)19-14)12-5-3-2-4-11(12)17/h2-8H,1H3,(H,18,19,21)	XBXGPAGZGXFFMF-UHFFFAOYSA-N	507765	US11130759, Cpd. No. 57::US11046691, Compound 57::7-chloro-1-(2-fluorophenyl)-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 57	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507765&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608698	459092850							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071615	O[C@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C18H16ClN3O2/c19-12-6-7-15-16(10-12)22(13-4-2-1-3-5-13)18(24)20-17(15)21-9-8-14(23)11-21/h1-7,10,14,23H,8-9,11H2	TXFRTHKEXGGQDR-UHFFFAOYSA-N	507766	US11130759, Cpd. No. 26::US11046691, Compound 26::(S)-7-chloro-4-(3-hydroxypyrrolidin-1- yl)-1-phenylquinazolin-2(1H)-one::US11084798, Cpd No 26	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507766&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608314	459092851							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071616	Nc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C14H10ClN3O/c15-9-6-7-11-12(8-9)18(14(19)17-13(11)16)10-4-2-1-3-5-10/h1-8H,(H2,16,17,19)	MKFLYUMLYCKMQT-UHFFFAOYSA-N	507767	US11130759, Cpd. No. 28::US11046691, Compound 59::4-amino-7-chloro-1-phenylquinazolin- 2(1H)-one::US11084798, Cpd No 59	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507767&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151081509	459092852							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071617	CN1CCN(CC1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C19H19ClN4O/c1-22-9-11-23(12-10-22)18-16-8-7-14(20)13-17(16)24(19(25)21-18)15-5-3-2-4-6-15/h2-8,13H,9-12H2,1H3	XMBDGIGQJORQGO-UHFFFAOYSA-N	507768	US11046691, Compound 27::7-chloro-4-(4-methylpiperazin-1-yl)-1- phenyl-quinazolin-2(1H)-one::US11084798, Cpd No 27	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507768&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152414063	459092853							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071618	CN(C)c1nc(=O)n(-c2cccc(Br)c2)c2cc(Cl)ccc12	InChI=1S/C16H13BrClN3O/c1-20(2)15-13-7-6-11(18)9-14(13)21(16(22)19-15)12-5-3-4-10(17)8-12/h3-9H,1-2H3	GFFAISUTMJRJHS-UHFFFAOYSA-N	507769	US11130759, Cpd. No. 60::US11046691, Compound 60::1-(3-bromophenyl)-7-chloro-4- (dimethylamino)quinazolin-2(1H)-one::US11084798, Cpd No 60	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507769&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608488	459092854							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071619	Clc1ccc2c(nc(=O)n(-c3ccccc3)c2c1)N1CCOCC1	InChI=1S/C18H16ClN3O2/c19-13-6-7-15-16(12-13)22(14-4-2-1-3-5-14)18(23)20-17(15)21-8-10-24-11-9-21/h1-7,12H,8-11H2	UOKVZXBPBPIDSE-UHFFFAOYSA-N	507770	US11046691, Compound 28::7-chloro-4-morpholino-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 28	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507770&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152039689	459092855							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071620	CNc1nc(=O)n(-c2cccc(F)c2)c2cc(Cl)ccc12	InChI=1S/C15H11ClFN3O/c1-18-14-12-6-5-9(16)7-13(12)20(15(21)19-14)11-4-2-3-10(17)8-11/h2-8H,1H3,(H,18,19,21)	IGCNCNQYVHDFQD-UHFFFAOYSA-N	507771	US11130759, Cpd. No. 61::US11046691, Compound 61::7-chloro-1-(3-fluorophenyl)-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 61	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507771&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608337	459092856							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071621	Clc1ccc2c(nc(=O)n(-c3ccccc3)c2c1)-n1cccn1	InChI=1S/C17H11ClN4O/c18-12-7-8-14-15(11-12)22(13-5-2-1-3-6-13)17(23)20-16(14)21-10-4-9-19-21/h1-11H	DCSCSNNOGBPRFF-UHFFFAOYSA-N	507772	US11130759, Cpd. No. 29::US11046691, Compound 29::7-chloro-1-phenyl-4-(1H-pyrazol-1- yl)quinazolin-2(1H)-one::US11084798, Cpd No 29	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507772&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150008083	459092857							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071622	COc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C15H11ClN2O2/c1-20-14-12-8-7-10(16)9-13(12)18(15(19)17-14)11-5-3-2-4-6-11/h2-9H,1H3	FBMLZTKVTZGARL-UHFFFAOYSA-N	507773	US11130759, Cpd. No. 62::US11046691, Compound 62::7-chloro-4-methoxy-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 62	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507773&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150132186	459092858							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071623	FC(F)CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C16H12ClF2N3O/c17-10-6-7-12-13(8-10)22(11-4-2-1-3-5-11)16(23)21-15(12)20-9-14(18)19/h1-8,14H,9H2,(H,20,21,23)	RCKBOTRENQKUPW-UHFFFAOYSA-N	507774	US11130759, Cpd. No. 31::US11046691, Compound 31::7-chloro-4((2,2-difluoroethyl)amino)- 1-phenyl-quinazolin-2 (1H)-one::US11084798, Cpd No 31	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507774&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151690232	459092859							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071624	CN(C)CCN(C)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C19H21ClN4O/c1-22(2)11-12-23(3)18-16-10-9-14(20)13-17(16)24(19(25)21-18)15-7-5-4-6-8-15/h4-10,13H,11-12H2,1-3H3	JSPPCRVFJVRMJZ-UHFFFAOYSA-N	507775	US11130759, Cpd. No. 63::US11046691, Compound 63::7-chloro-4-((2-(dimethylamino)ethyl)- (methyl)-amino)-1-phenylquinazolin- 2(1H)-one::US11084798, Cpd No 63	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507775&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150734852	459092860							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071625	Clc1ccc2c(Nc3ccccn3)nc(=O)n(-c3ccccc3)c2c1	InChI=1S/C19H13ClN4O/c20-13-9-10-15-16(12-13)24(14-6-2-1-3-7-14)19(25)23-18(15)22-17-8-4-5-11-21-17/h1-12H,(H,21,22,23,25)	JBFZUJWNQYPZJO-UHFFFAOYSA-N	507776	US11130759, Cpd. No. 32::US11046691, Compound 32::7-chloro-1-phenyl-4-(pyridin-2-yl- amino)quinazolin-2(1H)-one::US11084798, Cpd No 32	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507776&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150647801	459092861							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071626	CN(C)CCNc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C18H19ClN4O/c1-22(2)11-10-20-17-15-9-8-13(19)12-16(15)23(18(24)21-17)14-6-4-3-5-7-14/h3-9,12H,10-11H2,1-2H3,(H,20,21,24)	DBXUGFZRZAPDGR-UHFFFAOYSA-N	507777	US11130759, Cpd. No. 64::US11046691, Compound 64::7-chloro-4-((2-(dimethylamino)ethyl)- amino)-1-phenylquinazolin-2(1H)-one::US11084798, Cpd No 64	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507777&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147332495	459092862							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071627	CN(C)c1nc(=O)n(-c2ccccc2)c2cc(Br)ccc12	InChI=1S/C16H14BrN3O/c1-19(2)15-13-9-8-11(17)10-14(13)20(16(21)18-15)12-6-4-3-5-7-12/h3-10H,1-2H3	WAMFKQHBAJEYQT-UHFFFAOYSA-N	507778	US11130759, Cpd. No. 34::US11046691, Compound 34::7-bromo-4-(dimethylamino)-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 34	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507778&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609008	459092863							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071628	Clc1ccc2c(nc(=O)n(-c3ccccc3)c2c1)N1CCCCC1	InChI=1S/C19H18ClN3O/c20-14-9-10-16-17(13-14)23(15-7-3-1-4-8-15)19(24)21-18(16)22-11-5-2-6-12-22/h1,3-4,7-10,13H,2,5-6,11-12H2	DDBNBKVUTZCWCV-UHFFFAOYSA-N	507779	US11130759, Cpd. No. 66::US11046691, Compound 66::7-chloro-1-phenyl-4-(piperidin-1-yl)- quinazolin-2(1H)-one::US11084798, Cpd No 66	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507779&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150009980	459092864							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071629	CN(C)c1nc(=O)n(-c2ccccc2)c2cc(F)ccc12	InChI=1S/C16H14FN3O/c1-19(2)15-13-9-8-11(17)10-14(13)20(16(21)18-15)12-6-4-3-5-7-12/h3-10H,1-2H3	FJSWQAJRQVDKRX-UHFFFAOYSA-N	507780	US11130759, Cpd. No. 35::US11046691, Compound 35::4-(dimethylamino)-7-fluoro-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 35	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507780&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150172604	459092865							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071630	Clc1ccc2c(nc(=O)n(-c3ccccc3)c2c1)N1CCCC1	InChI=1S/C18H16ClN3O/c19-13-8-9-15-16(12-13)22(14-6-2-1-3-7-14)18(23)20-17(15)21-10-4-5-11-21/h1-3,6-9,12H,4-5,10-11H2	TVSANYPPCLLHDO-UHFFFAOYSA-N	507781	US11130759, Cpd. No. 230::US11046691, Compound 67::7-chloro-1-phenyl-4-(pyrrolidin-1-yl)- quinazolin-2(1H)-one::US11084798, Cpd No 67	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507781&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151946255	459092866							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071631	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(OC3CNC3)c12	InChI=1S/C18H17ClN4O2/c1-20-17-16-14(7-11(19)8-15(16)25-13-9-21-10-13)23(18(24)22-17)12-5-3-2-4-6-12/h2-8,13,21H,9-10H2,1H3,(H,20,22,24)	IHVQCVVCQZKTDI-UHFFFAOYSA-N	507782	US11130759, Cpd. No. 85::US11046691, Compound 85::5-azetidin-3-yloxy-7-chloro-4-(methyl- amino)-1-phenylhydroquinazolin-2-one::US11084798, Cpd No 85	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507782&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608654	459092867							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071632	CNc1nc(=O)n(-c2cccc(c2)C(F)(F)F)c2cc(Cl)ccc12	InChI=1S/C16H11ClF3N3O/c1-21-14-12-6-5-10(17)8-13(12)23(15(24)22-14)11-4-2-3-9(7-11)16(18,19)20/h2-8H,1H3,(H,21,22,24)	WBFMZMZSRKZQEO-UHFFFAOYSA-N	507786	US11130759, Cpd. No. 86::US11046691, Compound 86::7-chloro-4-(methylamino)-1-[3- (trifluoromethyl)phenyl]hydroquina- zolin-2-one::US11084798, Cpd No 86	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507786&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608240	459092871							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071633	CC1(CC1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(2.56,5.77,;2.56,4.23,;3.33,2.9,;4.1,4.23,;1.23,3.46,;1.23,1.92,;2.56,1.15,;2.56,-.39,;3.9,-1.16,;1.23,-1.16,;1.23,-2.7,;-.1,-3.47,;-.1,-5,;1.23,-5.77,;2.56,-5,;2.56,-3.47,;3.9,-2.69,;-.1,-.39,;-1.44,-1.15,;-2.77,-.38,;-2.77,1.16,;-1.44,1.93,;-.1,1.15,;-4.1,-1.15,;-5.44,-.38,;-4.1,-2.69,;-5.44,-1.92,)|	InChI=1S/C18H14ClF3N4O/c1-17(8-9-17)25-14-10-6-7-13(18(20,21)22)23-15(10)26(16(27)24-14)12-5-3-2-4-11(12)19/h2-7H,8-9H2,1H3,(H,24,25,27)	CUOOHCHLZQZALA-UHFFFAOYSA-N	507795	US11130759, Cpd. No. 88::US11046691, Compound 88::1-(2-chlorophenyl)-4((1-methylcyclo- propyl)amino)-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 87	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507795&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933689	459092880							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071634	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2Br)c2cc(Cl)ccc12 |r,wD:1.0,(-.34,6.43,;.56,5.18,;2.1,5.18,;2.58,3.72,;1.33,2.81,;.09,3.72,;1.33,1.27,;2.67,.5,;2.67,-1.04,;4,-1.81,;1.33,-1.81,;1.33,-3.35,;2.67,-4.12,;2.67,-5.66,;1.33,-6.43,;,-5.66,;,-4.12,;-1.33,-3.35,;,-1.04,;-1.33,-1.81,;-2.67,-1.04,;-4,-1.81,;-2.67,.5,;-1.33,1.27,;,.5,)|	InChI=1S/C18H15BrClN3O2/c19-14-3-1-2-4-15(14)23-16-9-11(20)5-6-13(16)17(21-18(23)25)22-8-7-12(24)10-22/h1-6,9,12,24H,7-8,10H2	RMGYURSMJZAIHE-UHFFFAOYSA-N	507791	US11130759, Cpd. No. 772::US11046691, Compound 87::4-((3R)-3-hydroxypyrrolidin-1-yl)-1-(2- bromophenyl)-7- chlorohydroquinazolin-2-one::US11084798, Cpd No 88	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507791&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151739753	459092876							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071635	c1ccc(cc1)N2c3cc(ccc3C(=NC2=O)N4CC[C@H](C4)F)Cl	InChI=1S/C18H15ClFN3O/c19-12-6-7-15-16(10-12)23(14-4-2-1-3-5-14)18(24)21-17(15)22-9-8-13(20)11-22/h1-7,10,13H,8-9,11H2	GPTUSHRRTGGGTD-UHFFFAOYSA-N	507736	US11130759, Cpd. No. 80::US11046691, Compound 80::(R)-7-chloro-4-(3-fluoropyrrolidin-1- yl)-1-phenylquinazolin-2(1H)-one::US11084798, Cpd No 80	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507736&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	UM6	8P4H	150331522	459092821							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071636	CNc1nc(=O)n(-c2ccnc(OC)c2)c2nc(ccc12)C(F)(F)F	InChI=1S/C15H12F3N5O2/c1-19-12-9-3-4-10(15(16,17)18)21-13(9)23(14(24)22-12)8-5-6-20-11(7-8)25-2/h3-7H,1-2H3,(H,19,22,24)	IHUMAWMVKPYYLH-UHFFFAOYSA-N	507803	US11130759, Cpd. No. 90::US11046691, Compound 90::1-(2-methoxypyridin-4-yl)-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 90	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507803&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514106	459092888							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071637	CNc1nc(=O)n(-c2cccc(OC)n2)c2nc(ccc12)C(F)(F)F	InChI=1S/C15H12F3N5O2/c1-19-12-8-6-7-9(15(16,17)18)20-13(8)23(14(24)22-12)10-4-3-5-11(21-10)25-2/h3-7H,1-2H3,(H,19,22,24)	PIWIFPPHKJMFOY-UHFFFAOYSA-N	507807	US11130759, Cpd. No. 91::US11046691, Compound 91::1-(6-methoxypyridin-2-yl)-4- (methylamino)-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 91	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507807&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514039	459092892							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071638	CNc1nc(=O)n(-c2cnccc2OC)c2nc(ccc12)C(F)(F)F |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.39,;1.33,-.39,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.7,;-1.33,-1.93,;-2.67,-2.7,;,.38,;-1.33,-.38,;-2.67,.39,;-2.67,1.93,;-1.33,2.7,;,1.92,;-4,-.38,;-5.33,.39,;-4,-1.92,;-5.33,-1.15,)|	InChI=1S/C15H12F3N5O2/c1-19-12-8-3-4-11(15(16,17)18)21-13(8)23(14(24)22-12)9-7-20-6-5-10(9)25-2/h3-7H,1-2H3,(H,19,22,24)	LWCFFXYDBDKDII-UHFFFAOYSA-N	507811	US11130759, Cpd. No. 92::US11046691, Compound 92::1-(4-methoxypyridin-3-yl)-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 92	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507811&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514060	459092896							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071639	CNc1nc(=O)n(-c2cc(OC)ccn2)c2nc(ccc12)C(F)(F)F	InChI=1S/C15H12F3N5O2/c1-19-12-9-3-4-10(15(16,17)18)21-13(9)23(14(24)22-12)11-7-8(25-2)5-6-20-11/h3-7H,1-2H3,(H,19,22,24)	RWVHQRZABCEWFZ-UHFFFAOYSA-N	507815	US11130759, Cpd. No. 93::US11046691, Compound 93::1-(4-methoxypyridin-2-yl)-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 93	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507815&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514029	459092900							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071640	O=c1nc(N2CCC2)c2ccc(cc2n1-c1ccccc1)N1CCC1	InChI=1S/C20H20N4O/c25-20-21-19(23-12-5-13-23)17-9-8-16(22-10-4-11-22)14-18(17)24(20)15-6-2-1-3-7-15/h1-3,6-9,14H,4-5,10-13H2	LBVUUMJRVKWMHT-UHFFFAOYSA-N	507819	US11130759, Cpd. No. 94::US11046691, Compound 94::4,7-di(azetidin-1-yl)-1-phenylhydro- quinazolin-2-one::US11084798, Cpd No 94	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507819&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608649	459092904							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071641	O=c1nc(N2CCC2)c2ccc(cc2n1-c1ccccc1)N1CCC1	InChI=1S/C20H20N4O/c25-20-21-19(23-12-5-13-23)17-9-8-16(22-10-4-11-22)14-18(17)24(20)15-6-2-1-3-7-15/h1-3,6-9,14H,4-5,10-13H2	LBVUUMJRVKWMHT-UHFFFAOYSA-N	507819	US11130759, Cpd. No. 94::US11046691, Compound 94::4,7-di(azetidin-1-yl)-1-phenylhydro- quinazolin-2-one::US11084798, Cpd No 94	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507819&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608649	459092904							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071642	CNc1nc(=O)n(-c2ccccc2)c2cc(C=C)ccc12	InChI=1S/C17H15N3O/c1-3-12-9-10-14-15(11-12)20(13-7-5-4-6-8-13)17(21)19-16(14)18-2/h3-11H,1H2,2H3,(H,18,19,21)	KIUFDVACCYNGKJ-UHFFFAOYSA-N	507826	US11130759, Cpd. No. 96::US11046691, Compound 96::4-(methylamino)-1-phenyl-7- vinylhydro-quinazolin-2-one::US11084798, Cpd No 96	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507826&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608308	459092911							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071643	CCCc1ccc2c(NC)nc(=O)n(-c3ccccc3)c2c1	InChI=1S/C18H19N3O/c1-3-7-13-10-11-15-16(12-13)21(14-8-5-4-6-9-14)18(22)20-17(15)19-2/h4-6,8-12H,3,7H2,1-2H3,(H,19,20,22)	GBDZFXFICWSUSQ-UHFFFAOYSA-N	507830	US11130759, Cpd. No. 97::US11046691, Compound 97::4-(methylamino)-1-phenyl-7- propylhydroquinazolin-2-one::US11084798, Cpd No 97	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507830&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608885	459092915							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071645	Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |(1.33,4.62,;1.33,3.08,;2.67,2.31,;2.67,.77,;4,,;1.33,,;1.33,-1.54,;2.67,-2.31,;2.67,-3.85,;1.33,-4.62,;,-3.85,;,-2.31,;-1.33,-1.54,;,.77,;-1.33,,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;-4,,;-5.33,.77,;-4,-1.54,;-5.33,-.77,)|	InChI=1S/C15H9ClF3N3O/c16-10-3-1-2-4-11(10)22-12-7-8(15(17,18)19)5-6-9(12)13(20)21-14(22)23/h1-7H,(H2,20,21,23)	ODCMIQDSIFEWCL-UHFFFAOYSA-N	507837	US11130759, Cpd. No. 99::US11046691, Compound 99::4-amino-1-(2-chlorophenyl)-7- (trifluoromethyl)hydroquinazolin-2-one::US11084798, Cpd No 99	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507837&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608563	459092922							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071646	FC(F)CNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |(4,6.16,;2.67,5.39,;1.33,6.16,;2.67,3.85,;1.33,3.08,;1.33,1.54,;2.67,.77,;2.67,-.77,;4,-1.54,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;1.33,-6.16,;,-5.39,;,-3.85,;-1.33,-3.08,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;,.77,;-4,-1.54,;-5.33,-.77,;-4,-3.08,;-5.33,-2.31,)|	InChI=1S/C17H11ClF5N3O/c18-11-3-1-2-4-12(11)26-13-7-9(17(21,22)23)5-6-10(13)15(25-16(26)27)24-8-14(19)20/h1-7,14H,8H2,(H,24,25,27)	ZCNAYJYLFFYUKP-UHFFFAOYSA-N	507841	US11130759, Cpd. No. 100::US11046691, Compound 100::1-(2-chlorophenyl)-4-[(2,2-difluoro- ethyl)amino]-7-(trifluoromethyl)hy- droquinazolin-2-one::US11084798, Cpd No 100	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507841&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608715	459092926							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071647	FC(F)(F)CNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |(3.92,6.16,;2.59,5.39,;1.26,6.16,;4.08,4.99,;2.59,3.85,;1.26,3.08,;1.26,1.54,;2.59,.77,;2.59,-.77,;3.92,-1.54,;1.26,-1.54,;1.26,-3.08,;2.59,-3.85,;2.59,-5.39,;1.26,-6.16,;-.08,-5.39,;-.08,-3.85,;-1.41,-3.08,;-.08,-.77,;-1.41,-1.54,;-2.74,-.77,;-2.74,.77,;-1.41,1.54,;-.08,.77,;-4.08,-1.54,;-5.41,-.77,;-4.08,-3.08,;-5.41,-2.31,)|	InChI=1S/C17H10ClF6N3O/c18-11-3-1-2-4-12(11)27-13-7-9(17(22,23)24)5-6-10(13)14(26-15(27)28)25-8-16(19,20)21/h1-7H,8H2,(H,25,26,28)	OFPKGYXHSBOREY-UHFFFAOYSA-N	507845	US11130759, Cpd. No. 101::US11046691, Compound 101::1-(2-chlorophenyl)-4-[(2,2,2-trifluoro- ethyl)amino]-7-(trifluoromethyl)hydro- quinazolin-2-one::US11084798, Cpd No 101	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507845&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608898	459092930							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071648	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |(2.5,5.02,;1.19,4.21,;1.24,2.67,;2.6,1.94,;2.64,.4,;4,-.32,;1.33,-.4,;1.38,-1.94,;2.74,-2.67,;2.78,-4.21,;1.47,-5.02,;.12,-4.29,;.07,-2.75,;-1.29,-2.02,;-.02,.32,;-1.33,-.48,;-2.69,.24,;-2.74,1.78,;-1.43,2.59,;-.07,1.86,;-4,-.57,;-5.36,.16,;-3.95,-2.1,;-5.31,-1.37,)|	InChI=1S/C16H11ClF3N3O/c1-21-14-10-7-6-9(16(18,19)20)8-13(10)23(15(24)22-14)12-5-3-2-4-11(12)17/h2-8H,1H3,(H,21,22,24)	HNZZCNOJHCROCO-UHFFFAOYSA-N	507848	US11130759, Cpd. No. 102::US11046691, Compound 102::1-(2-chlorophenyl)-4-(methylamino)-7- (trifluoromethyl)hydroquinazolin-2-one::US11084798, Cpd No 102	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507848&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609047	459092933							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071649	FC(F)(F)c1ccc2c(c1)n(-c1ccccc1Cl)c(=O)[nH]c2=O |(-5.33,.77,;-4,,;-4,-1.54,;-5.33,-.77,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;,.77,;-1.33,,;1.33,,;1.33,-1.54,;2.67,-2.31,;2.67,-3.85,;1.33,-4.62,;,-3.85,;,-2.31,;-1.33,-1.54,;2.67,.77,;4,,;2.67,2.31,;1.33,3.08,;1.33,4.62,)|	InChI=1S/C15H8ClF3N2O2/c16-10-3-1-2-4-11(10)21-12-7-8(15(17,18)19)5-6-9(12)13(22)20-14(21)23/h1-7H,(H,20,22,23)	BCIPKYMWWRESHA-UHFFFAOYSA-N	507851	US11046691, Compound 103::BDBM511774::1-(2-chlorophenyl)-7-(trifluoromethyl)- 1,3-dihydroquinazoline-2,4-dione::US11130759, Cpd. No. 103	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507851&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370653	459092936							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071650	CC(C)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C17H15ClN2O/c1-11(2)16-14-9-8-12(18)10-15(14)20(17(21)19-16)13-6-4-3-5-7-13/h3-11H,1-2H3	OFLTYINRJQHOAW-UHFFFAOYSA-N	507854	US11130759, Cpd. No. 104::US11046691, Compound 104::7-chloro-4-(methylethyl)-1- phenylhydro-quinazolin-2-one::US11084798, Cpd No 104	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507854&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608955	459092939							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071651	CCc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C16H13ClN2O/c1-2-14-13-9-8-11(17)10-15(13)19(16(20)18-14)12-6-4-3-5-7-12/h3-10H,2H2,1H3	IAVOXTRIOIPUCK-UHFFFAOYSA-N	507857	US11130759, Cpd. No. 105::US11046691, Compound 105::7-chloro-4-ethyl-1-phenylhydro- quinazolin-2-one::US11084798, Cpd No 105	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507857&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514040	459092942							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071652	CNc1nc(=O)n(-c2nccc(OC)n2)c2cc(Cl)ccc12	InChI=1S/C14H12ClN5O2/c1-16-12-9-4-3-8(15)7-10(9)20(14(21)19-12)13-17-6-5-11(18-13)22-2/h3-7H,1-2H3,(H,16,19,21)	KXCFVEDEJWRBIZ-UHFFFAOYSA-N	507860	US11130759, Cpd. No. 106::US11046691, Compound 106::7-chloro-1-(4-methoxypyrimidin-2-yl)- 4-(methylamino)hydroquinazolin-2-one::US11084798, Cpd No 106	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507860&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514041	459092944							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071653	Cc1c(cccc1-n1c2cc(Cl)ccc2c(=O)[nH]c1=O)C#N |(-1.39,-1.13,;-.09,-1.95,;-.15,-3.49,;1.16,-4.31,;2.52,-3.59,;2.58,-2.05,;1.27,-1.23,;1.33,.31,;.03,1.13,;-1.33,.41,;-2.64,1.23,;-4,.51,;-2.58,2.77,;-1.22,3.49,;.09,2.67,;1.45,3.39,;1.51,4.93,;2.75,2.57,;2.69,1.03,;4,.21,;-1.51,-4.21,;-2.87,-4.93,)|	InChI=1S/C16H10ClN3O2/c1-9-10(8-18)3-2-4-13(9)20-14-7-11(17)5-6-12(14)15(21)19-16(20)22/h2-7H,1H3,(H,19,21,22)	XDBKSUCZBONWHK-UHFFFAOYSA-N	507863	US11130759, Cpd. No. 107::US11046691, Compound 107::3-(7-chloro-2,4-dioxo-3,4-dihydro- quinazolin-1(2H)-yl)-2-methyl- benzonitrile::US11084798, Cpd No 107	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507863&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370655	459092947							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071654	Cc1ccc(cc1-n1c2cc(Cl)ccc2c(=O)[nH]c1=O)C#N |(-2.03,-1.27,;-.68,-2.01,;-.64,-3.55,;.72,-4.28,;2.03,-3.48,;1.99,-1.94,;.64,-1.21,;.6,.33,;-.75,1.07,;-2.07,.27,;-3.42,1,;-4.73,.2,;-3.46,2.54,;-2.15,3.35,;-.79,2.61,;.52,3.41,;.48,4.95,;1.87,2.68,;1.91,1.14,;3.26,.4,;3.38,-4.22,;4.73,-4.95,)|	InChI=1S/C16H10ClN3O2/c1-9-2-3-10(8-18)6-13(9)20-14-7-11(17)4-5-12(14)15(21)19-16(20)22/h2-7H,1H3,(H,19,21,22)	PWLPMPDQPRCFOM-UHFFFAOYSA-N	507866	US11130759, Cpd. No. 108::US11046691, Compound 108::3-(7-chloro-2,4-dioxo-3,4-dihydro- quinazolin-1(2H)-yl)-4-methyl- benzonitrile::US11084798, Cpd No 108	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507866&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370656	459092950							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071655	CNc1nc(=O)n(-c2cc(O)ccc2C)c2cc(Cl)ccc12 |(2.85,5.03,;1.49,4.3,;1.44,2.76,;2.75,1.95,;2.69,.41,;4,-.41,;1.33,-.31,;1.28,-1.85,;2.59,-2.67,;2.53,-4.21,;3.84,-5.03,;1.17,-4.93,;-.13,-4.12,;-.08,-2.58,;-1.39,-1.76,;.03,.5,;-1.33,-.22,;-2.64,.59,;-4,-.13,;-2.59,2.13,;-1.23,2.86,;.08,2.04,)|	InChI=1S/C16H14ClN3O2/c1-9-3-5-11(21)8-13(9)20-14-7-10(17)4-6-12(14)15(18-2)19-16(20)22/h3-8,21H,1-2H3,(H,18,19,22)	OICSXNZRIFNTFZ-UHFFFAOYSA-N	507869	US11130759, Cpd. No. 109::US11046691, Compound 109::7-chloro-1-(3-hydroxy-6- methylphenyl)-4- (methylamino)hydroquinazolin-2-one::US11084798, Cpd No 109	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507869&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608534	459092953							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071656	Cc1c(O)cccc1-n1c2cc(Cl)ccc2c(=O)[nH]c1=O |(4,-1.54,;2.67,-2.31,;2.67,-3.85,;4,-4.62,;1.33,-4.62,;,-3.85,;,-2.31,;1.33,-1.54,;1.33,,;,.77,;-1.33,,;-2.67,.77,;-4,,;-2.67,2.31,;-1.33,3.08,;,2.31,;1.33,3.08,;1.33,4.62,;2.67,2.31,;2.67,.77,;4,,)|	InChI=1S/C15H11ClN2O3/c1-8-11(3-2-4-13(8)19)18-12-7-9(16)5-6-10(12)14(20)17-15(18)21/h2-7,19H,1H3,(H,17,20,21)	CEUJXAVZBLZHDZ-UHFFFAOYSA-N	507872	US11130759, Cpd. No. 110::US11046691, Compound 110::7-chloro-1-(3-hydroxy-2- methylphenyl)-1,3-dihydroquinazoline- 2,4-dione::US11084798, Cpd No 110	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507872&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370657	459092956							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071657	Nc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(-n3nccn3)c12	InChI=1S/C16H11ClN6O/c17-10-8-12-14(13(9-10)23-19-6-7-20-23)15(18)21-16(24)22(12)11-4-2-1-3-5-11/h1-9H,(H2,18,21,24)	NOUNWBKPPAXOIM-UHFFFAOYSA-N	507875	US11130759, Cpd. No. 112::US11046691, Compound 112::4-amino-7-chloro-1-phenyl-5-(1,2,3- triazol-2-yl)hydroquinazolin-2-one::US11084798, Cpd No 112	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507875&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608685	459092959							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071658	CNc1nc(=O)n(-c2nc(cs2)C(F)(F)F)c2cc(Cl)ccc12	InChI=1S/C13H8ClF3N4OS/c1-18-10-7-3-2-6(14)4-8(7)21(11(22)20-10)12-19-9(5-23-12)13(15,16)17/h2-5H,1H3,(H,18,20,22)	OMIKFGWTKNSLHT-UHFFFAOYSA-N	507878	US11130759, Cpd. No. 113::US11046691, Compound 113::7-chloro-4-(methylamino)-1-[4- (trifluoromethyl)(1,3-thiazol-2- yl)]hydroquinazolin-2-one::US11084798, Cpd No 113	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507878&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608959	459092962							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071659	CNc1nc(=O)n(-c2cccnc2)c2cc(Cl)ccc12	InChI=1S/C14H11ClN4O/c1-16-13-11-5-4-9(15)7-12(11)19(14(20)18-13)10-3-2-6-17-8-10/h2-8H,1H3,(H,16,18,20)	KOKAWMZINRQQGS-UHFFFAOYSA-N	507881	US11130759, Cpd. No. 114::US11046691, Compound 114::7-chloro-4-(methylamino)-1-(3- pyridyl)-hydroquinazolin-2-one::US11084798, Cpd No 114	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507881&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148234347	459092965							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071660	CCc1ccc2c(NC)nc(=O)n(-c3ccccc3)c2c1	InChI=1S/C17H17N3O/c1-3-12-9-10-14-15(11-12)20(13-7-5-4-6-8-13)17(21)19-16(14)18-2/h4-11H,3H2,1-2H3,(H,18,19,21)	FMIHJUKSAYLATN-UHFFFAOYSA-N	507884	US11130759, Cpd. No. 115::US11046691, Compound 115::7-ethyl-4-(methylamino)-1- phenylhydro-quinazolin-2-one::US11084798, Cpd No 115	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507884&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147527223	459092968							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071661	CNc1nc(=O)n(-c2ncc(C)s2)c2cc(Cl)ccc12	InChI=1S/C13H11ClN4OS/c1-7-6-16-13(20-7)18-10-5-8(14)3-4-9(10)11(15-2)17-12(18)19/h3-6H,1-2H3,(H,15,17,19)	CSRGDXSUWUUZQA-UHFFFAOYSA-N	507887	US11130759, Cpd. No. 116::US11046691, Compound 116::7-chloro-1-(5-methyl(1,3-thiazol-2-yl))- 4-(methylamino)hydroquinazolin-2-one::US11084798, Cpd No 116	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507887&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147282973	459092971							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071662	CNc1nc(=O)n(-c2nc(C)cs2)c2cc(Cl)ccc12	InChI=1S/C13H11ClN4OS/c1-7-6-20-13(16-7)18-10-5-8(14)3-4-9(10)11(15-2)17-12(18)19/h3-6H,1-2H3,(H,15,17,19)	AVYVLQTXOKRNAU-UHFFFAOYSA-N	507890	US11130759, Cpd. No. 117::US11046691, Compound 117::7-chloro-1-(4-methyl(1,3-thiazol-2-yl))- 4-(methylamino)hydroquinazolin-2-one::US11084798, Cpd No 117	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507890&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147022378	459092974							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071663	FC(F)(F)CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C17H11F6N3O/c18-16(19,20)9-24-14-12-7-6-10(17(21,22)23)8-13(12)26(15(27)25-14)11-4-2-1-3-5-11/h1-8H,9H2,(H,24,25,27)	KNJQTAAZTOJAGD-UHFFFAOYSA-N	507893	US11130759, Cpd. No. 118::US11046691, Compound 118::1-phenyl-4-[(2,2,2- trifluoroethyl)amino]-7- (trifluoromethyphydroquinazolin-2-one::US11084798, Cpd No 118	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507893&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148228893	459092977							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071664	FC(F)CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C17H12F5N3O/c18-14(19)9-23-15-12-7-6-10(17(20,21)22)8-13(12)25(16(26)24-15)11-4-2-1-3-5-11/h1-8,14H,9H2,(H,23,24,26)	VGCGDHLGCCEAMJ-UHFFFAOYSA-N	507896	US11130759, Cpd. No. 119::US11046691, Compound 119::4-[(2,2-difluoroethyl)amino]-1-phenyl- 7-(trifluoromethyl)hydroquinazolin-2- one::US11084798, Cpd No 119	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507896&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153043204	459092979							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071665	COc1nc(=O)n(-c2ncccn2)c2cc(ccc12)C(F)(F)F	InChI=1S/C14H9F3N4O2/c1-23-11-9-4-3-8(14(15,16)17)7-10(9)21(13(22)20-11)12-18-5-2-6-19-12/h2-7H,1H3	QKYDQWSHPJHUFY-UHFFFAOYSA-N	507899	US11130759, Cpd. No. 120::US11046691, Compound 120::4-methoxy-1-pyrimidin-2-yl-7- (trifluoro-methyphydroquinazolin-2- one::US11084798, Cpd No 120	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507899&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149056508	459092982							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071666	FC(F)(F)CNc1nc(=O)n(-c2ncccn2)c2cc(ccc12)C(F)(F)F	InChI=1S/C15H9F6N5O/c16-14(17,18)7-24-11-9-3-2-8(15(19,20)21)6-10(9)26(13(27)25-11)12-22-4-1-5-23-12/h1-6H,7H2,(H,24,25,27)	BPLWHEGZPPMOLH-UHFFFAOYSA-N	507902	US11130759, Cpd. No. 121::US11046691, Compound 121::1-pyrimidin-2-yl-4-[(2,2,2-trifluoro- ethyparnino]-7-(trifluoromethyphydro- quinazolin-2-one::US11084798, Cpd No 121	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507902&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609033	459092984							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071667	FC(F)CNc1nc(=O)n(-c2ncccn2)c2cc(ccc12)C(F)(F)F	InChI=1S/C15H10F5N5O/c16-11(17)7-23-12-9-3-2-8(15(18,19)20)6-10(9)25(14(26)24-12)13-21-4-1-5-22-13/h1-6,11H,7H2,(H,23,24,26)	HQKXICVZJLEMCX-UHFFFAOYSA-N	507905	US11130759, Cpd. No. 122::US11046691, Compound 122::4-[(2,2-difluoroethyl)amino]-1- pyrimidin-2-yl-7- (trifluoromethyl)hydro- quinazolin-2-one::US11084798, Cpd No 122	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507905&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608353	459092987							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071668	CNc1nc(=O)n(-c2ncccn2)c2cc(ccc12)C(F)(F)F	InChI=1S/C14H10F3N5O/c1-18-11-9-4-3-8(14(15,16)17)7-10(9)22(13(23)21-11)12-19-5-2-6-20-12/h2-7H,1H3,(H,18,21,23)	CAELLEADXBALEH-UHFFFAOYSA-N	507908	US11130759, Cpd. No. 123::US11046691, Compound 123::4-(methylamino)-1-pyrimidin-2-yl-7- (trifluoromethyl)hydroquinazolin-2-one::US11084798, Cpd No 123	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507908&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608887	459092990							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071669	Nc1nc(=O)n(-c2ncccn2)c2cc(ccc12)C(F)(F)F	InChI=1S/C13H8F3N5O/c14-13(15,16)7-2-3-8-9(6-7)21(12(22)20-10(8)17)11-18-4-1-5-19-11/h1-6H,(H2,17,20,22)	OZBMXTKYXYSWES-UHFFFAOYSA-N	507911	US11130759, Cpd. No. 124::US11046691, Compound 124::4-amino-1-pyrimidin-2-yl-7-(trifluoro- methyl)hydroquinazolin-2-one::US11084798, Cpd No 124	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507911&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608363	459092993							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071670	Cc1ccccc1-n1c2cc(ccc2c(N)nc1=O)C(F)(F)F |(-1.33,-1.54,;,-2.31,;,-3.85,;1.33,-4.62,;2.67,-3.85,;2.67,-2.31,;1.33,-1.54,;1.33,,;,.77,;-1.33,,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;1.33,3.08,;1.33,4.62,;2.67,2.31,;2.67,.77,;4,,;-4,,;-5.33,.77,;-4,-1.54,;-5.33,-.77,)|	InChI=1S/C16H12F3N3O/c1-9-4-2-3-5-12(9)22-13-8-10(16(17,18)19)6-7-11(13)14(20)21-15(22)23/h2-8H,1H3,(H2,20,21,23)	NWQOUPGAZRWVRP-UHFFFAOYSA-N	507914	US11130759, Cpd. No. 125::US11046691, Compound 125::4-amino-1-(2-methylphenyl)-7- (trifluoromethyl)hydroquinazolin-2-one::US11084798, Cpd No 125	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507914&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608292	459092996							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071671	Cc1ccccc1-n1c2cc(ccc2c(NCC(F)(F)F)nc1=O)C(F)(F)F |(-1.41,-3.08,;-.08,-3.85,;-.08,-5.39,;1.26,-6.16,;2.59,-5.39,;2.59,-3.85,;1.26,-3.08,;1.26,-1.54,;-.08,-.77,;-1.41,-1.54,;-2.74,-.77,;-2.74,.77,;-1.41,1.54,;-.08,.77,;1.26,1.54,;1.26,3.08,;2.59,3.85,;2.59,5.39,;1.26,6.16,;3.92,6.16,;4.08,4.99,;2.59,.77,;2.59,-.77,;3.92,-1.54,;-4.08,-1.54,;-5.41,-.77,;-4.08,-3.08,;-5.41,-2.31,)|	InChI=1S/C18H13F6N3O/c1-10-4-2-3-5-13(10)27-14-8-11(18(22,23)24)6-7-12(14)15(26-16(27)28)25-9-17(19,20)21/h2-8H,9H2,1H3,(H,25,26,28)	AYEBXSICKKLALZ-UHFFFAOYSA-N	507917	US11130759, Cpd. No. 126::US11046691, Compound 126::1-(2-methylphenyl)-4-[(2,2,2-trifluoro- ethyl)amino]-7-(trifluoromethyl)hydro- quinazolin-2-one::US11084798, Cpd No 126	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507917&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608426	459092999							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071672	Cc1ccccc1-n1c2cc(ccc2c(NCC(F)F)nc1=O)C(F)(F)F |(-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;2.67,-5.39,;2.67,-3.85,;1.33,-3.08,;1.33,-1.54,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;,.77,;1.33,1.54,;1.33,3.08,;2.67,3.85,;2.67,5.39,;1.33,6.16,;4,6.16,;2.67,.77,;2.67,-.77,;4,-1.54,;-4,-1.54,;-5.33,-.77,;-4,-3.08,;-5.33,-2.31,)|	InChI=1S/C18H14F5N3O/c1-10-4-2-3-5-13(10)26-14-8-11(18(21,22)23)6-7-12(14)16(25-17(26)27)24-9-15(19)20/h2-8,15H,9H2,1H3,(H,24,25,27)	QDYVUDWCDOWFQN-UHFFFAOYSA-N	507920	US11130759, Cpd. No. 127::US11046691, Compound 127::4-[(2,2-difluoroethyl)amino]-1-(2- methylphenyl)-7- (trifluoromethyl)hydro-quinazolin-2- one::US11084798, Cpd No 127	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507920&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151568668	459093002							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071673	Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1CC[C@@H](O)C1)C(F)(F)F |r,wD:21.24,(-1.33,-3.35,;,-4.12,;,-5.66,;1.33,-6.43,;2.67,-5.66,;2.67,-4.12,;1.33,-3.35,;1.33,-1.81,;,-1.04,;-1.33,-1.81,;-2.67,-1.04,;-2.67,.5,;-1.33,1.27,;,.5,;1.33,1.27,;2.67,.5,;2.67,-1.04,;4,-1.81,;1.33,2.81,;2.58,3.72,;2.1,5.18,;.56,5.18,;-.34,6.43,;.09,3.72,;-4,-1.81,;-5.33,-1.04,;-4,-3.35,;-5.33,-2.58,)|	InChI=1S/C20H18F3N3O2/c1-12-4-2-3-5-16(12)26-17-10-13(20(21,22)23)6-7-15(17)18(24-19(26)28)25-9-8-14(27)11-25/h2-7,10,14,27H,8-9,11H2,1H3	XZKWULGFCVGHOD-UHFFFAOYSA-N	507923	US11130759, Cpd. No. 128::US11046691, Compound 128::4-((3R)-3-hydroxypyrrolidin-1-yl)-1-(2- methylphenyl)-7- (trifluoromethyl)hydro-quinazolin-2- one::US11084798, Cpd No 128	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507923&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149315513	459093005							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071674	CNc1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.93,;,.38,;-1.33,-.38,;-2.67,.38,;-2.67,1.93,;-1.33,2.69,;,1.93,;-4,-.38,;-5.33,.39,;-4,-1.92,;-5.33,-1.15,)|	InChI=1S/C17H14F3N3O/c1-10-5-3-4-6-13(10)23-14-9-11(17(18,19)20)7-8-12(14)15(21-2)22-16(23)24/h3-9H,1-2H3,(H,21,22,24)	AMHMREQJMOJQHY-UHFFFAOYSA-N	507926	US11130759, Cpd. No. 367::US11046691, Compound 129::4-(methylamino)-1-(2-methylphenyl)-7- (trifluoromethyl)hydroquinazolin-2-one::US11084798, Cpd No 129	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507926&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			146970364	459093008							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071675	O=c1[nH]c(=O)c2ccc(cc2n1-c1ccccc1)C1CC1	InChI=1S/C17H14N2O2/c20-16-14-9-8-12(11-6-7-11)10-15(14)19(17(21)18-16)13-4-2-1-3-5-13/h1-5,8-11H,6-7H2,(H,18,20,21)	WBMCGBRUFLCQIO-UHFFFAOYSA-N	507929	US11130759, Cpd. No. 130::US11046691, Compound 130::7-cyclopropyl-1-phenyl-1,3-dihydro- quinazoline-2,4-dione::US11084798, Cpd No 130	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507929&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370660	459093011							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071676	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(OC3CN(C3)C(=O)OC(C)(C)C)c12	InChI=1S/C23H25ClN4O4/c1-23(2,3)32-22(30)27-12-16(13-27)31-18-11-14(24)10-17-19(18)20(25-4)26-21(29)28(17)15-8-6-5-7-9-15/h5-11,16H,12-13H2,1-4H3,(H,25,26,29)	XMFPEAMEKBXYMW-UHFFFAOYSA-N	507932	US11130759, Cpd. No. 132::US11046691, Compound 132::tert-butyl 3-[7-chloro-4-(methylamino)- 2-oxo-1-phenylhydroquinazolin-5-yl- oxy]azetidinecarboxylate::US11084798, Cpd No 132	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507932&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149241263	459093014							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071677	CNc1nc(=O)n(-c2cccc(c2)C(O)=O)c2cc(Cl)ccc12	InChI=1S/C16H12ClN3O3/c1-18-14-12-6-5-10(17)8-13(12)20(16(23)19-14)11-4-2-3-9(7-11)15(21)22/h2-8H,1H3,(H,21,22)(H,18,19,23)	JFFGHICYIFZORF-UHFFFAOYSA-N	507935	US11130759, Cpd. No. 133::US11046691, Compound 133::3-[7-chloro-4-(methylamino)-2-oxo- hydroquinazolin-1-yl]benzoic acid::US11084798, Cpd No 133	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507935&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148044945	459093017							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071678	CNc1nc(=O)n(-c2cccc(c2)C(N)=O)c2cc(Cl)ccc12	InChI=1S/C16H13ClN4O2/c1-19-15-12-6-5-10(17)8-13(12)21(16(23)20-15)11-4-2-3-9(7-11)14(18)22/h2-8H,1H3,(H2,18,22)(H,19,20,23)	BBUOYYADTVVJPK-UHFFFAOYSA-N	507938	US11130759, Cpd. No. 134::US11046691, Compound 134::3-[7-chloro-4-(methylamino)-2-oxo- hydroquinazolin-1-yl]benzamide::US11084798, Cpd No 134	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507938&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147053611	459093020							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071679	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2Cl)c2cc(Cl)ccc12 |r,wD:1.0,(-.34,6.43,;.56,5.18,;2.1,5.18,;2.58,3.72,;1.33,2.81,;.09,3.72,;1.33,1.27,;2.67,.5,;2.67,-1.04,;4,-1.81,;1.33,-1.81,;1.33,-3.35,;2.67,-4.12,;2.67,-5.66,;1.33,-6.43,;,-5.66,;,-4.12,;-1.33,-3.35,;,-1.04,;-1.33,-1.81,;-2.67,-1.04,;-4,-1.81,;-2.67,.5,;-1.33,1.27,;,.5,)|	InChI=1S/C18H15Cl2N3O2/c19-11-5-6-13-16(9-11)23(15-4-2-1-3-14(15)20)18(25)21-17(13)22-8-7-12(24)10-22/h1-6,9,12,24H,7-8,10H2	LJDNULCGRVBJBW-UHFFFAOYSA-N	507941	US11130759, Cpd. No. 153::4-((3R)-3-hydroxypyrrolidin-1-yl)-7- chloro-1-(2-chlorophenyl)hydro- quinazolin-2-one::US11046691, Compound 153::US11046691, Compound 135::US11084798, Cpd No 153	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507941&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148354417	459093023							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071680	FC(F)(F)CNc1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F	InChI=1S/C16H10F6N4O/c17-15(18,19)8-23-12-10-6-7-11(16(20,21)22)24-13(10)26(14(27)25-12)9-4-2-1-3-5-9/h1-7H,8H2,(H,23,25,27)	FNXGPXCQVCOXLF-UHFFFAOYSA-N	507944	US11130759, Cpd. No. 136::US11046691, Compound 136::1-phenyl-4-((2,2,2- trifluoroethyl)amino)-7- (trifluoromethyl)pyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 136	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507944&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609070	459093026							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071681	FC(F)CNc1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F	InChI=1S/C16H11F5N4O/c17-12(18)8-22-13-10-6-7-11(16(19,20)21)23-14(10)25(15(26)24-13)9-4-2-1-3-5-9/h1-7,12H,8H2,(H,22,24,26)	VLDISPJJBGBGFO-UHFFFAOYSA-N	507947	US11130759, Cpd. No. 137::US11046691, Compound 137::4-((2,2-difluoroethyl)amino)-1-phenyl- 7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 137	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507947&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608919	459093029							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071682	Nc1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F	InChI=1S/C14H9F3N4O/c15-14(16,17)10-7-6-9-11(18)20-13(22)21(12(9)19-10)8-4-2-1-3-5-8/h1-7H,(H2,18,20,22)	NPBVGFXDUTVFLL-UHFFFAOYSA-N	507950	US11130759, Cpd. No. 138::US11046691, Compound 138::4-amino-1-phenyl-7-(trifluoromethyl)- hydropyridino[2,3-d]pyrimidin-2-one::US11084798, Cpd No 138	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507950&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608312	459093032							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071683	OC1CN(C1)c1nc(=O)n(-c2cccc(c2)C#N)c2cc(ccc12)C(F)(F)F	InChI=1S/C19H13F3N4O2/c20-19(21,22)12-4-5-15-16(7-12)26(13-3-1-2-11(6-13)8-23)18(28)24-17(15)25-9-14(27)10-25/h1-7,14,27H,9-10H2	GDUSYMAGHASSJY-UHFFFAOYSA-N	507953	US11130759, Cpd. No. 139::US11046691, Compound 139::3-[4-(3-hydroxyazetidinyl)-2-oxo-7- (trifluoromethyl)hydroquinazolinyl]- benzenecarbonitrile::US11084798, Cpd No 139	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507953&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608845	459093035							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071684	Nc1nc(=O)n(-c2cccc(c2)C#N)c2cc(ccc12)C(F)(F)F	InChI=1S/C16H9F3N4O/c17-16(18,19)10-4-5-12-13(7-10)23(15(24)22-14(12)21)11-3-1-2-9(6-11)8-20/h1-7H,(H2,21,22,24)	WWDYHWGHVSHILJ-UHFFFAOYSA-N	507956	US11130759, Cpd. No. 140::US11046691, Compound 140::3-[4-amino-2-oxo-7-(trifluoromethyl)- hydroquinazolinyl]benzenecarbonitrile::US11084798, Cpd No 140	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507956&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608399	459093038							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071685	O[C@@H]1CCN(C1)c1nc(=O)n(-c2cccc(c2)C#N)c2cc(ccc12)C(F)(F)F |r|	InChI=1S/C20H15F3N4O2/c21-20(22,23)13-4-5-16-17(9-13)27(14-3-1-2-12(8-14)10-24)19(29)25-18(16)26-7-6-15(28)11-26/h1-5,8-9,15,28H,6-7,11H2	IPWBDUNLDAFUED-UHFFFAOYSA-N	507959	US11130759, Cpd. No. 141::US11046691, Compound 141::3-[4-(((3R)-3-hydroxypyrrolidinyl)-2- oxo-7-(trifluoromethyl)hydro- quinazolinyl]-benzenecarbonitrile::US11084798, Cpd No 141	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507959&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933490	459093041							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071686	CNc1nc(=O)n(-c2cccc(c2)C#N)c2cc(ccc12)C(F)(F)F	InChI=1S/C17H11F3N4O/c1-22-15-13-6-5-11(17(18,19)20)8-14(13)24(16(25)23-15)12-4-2-3-10(7-12)9-21/h2-8H,1H3,(H,22,23,25)	ODJZWVNRNKEOEF-UHFFFAOYSA-N	507962	US11130759, Cpd. No. 142::US11046691, Compound 142::3[4-(methylamino)-2-oxo-7-(trifluoro- methyl)hydroquinazolinyl]benzene- carbonitrile::US11084798, Cpd No 142	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507962&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148743987	459093044							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071687	CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)F	InChI=1S/C16H13F2N3O/c1-19-15-12-8-7-10(14(17)18)9-13(12)21(16(22)20-15)11-5-3-2-4-6-11/h2-9,14H,1H3,(H,19,20,22)	JSUWTIRRIFEOFL-UHFFFAOYSA-N	507965	US11130759, Cpd. No. 143::US11046691, Compound 143::7-(difluoromethyl)-4-(methylamino)-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 143	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507965&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609067	459093047							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071688	COc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C16H11F3N2O2/c1-23-14-12-8-7-10(16(17,18)19)9-13(12)21(15(22)20-14)11-5-3-2-4-6-11/h2-9H,1H3	ABQBRDNNMPSSLX-UHFFFAOYSA-N	507968	US11130759, Cpd. No. 144::US11046691, Compound 144::4-methoxy-1-phenyl-7- (trifluoromethyl)-hydroquinazolin-2- one::US11084798, Cpd No 144	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507968&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			146912762	459093050							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071689	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F |r|	InChI=1S/C19H16F3N3O2/c20-19(21,22)12-6-7-15-16(10-12)25(13-4-2-1-3-5-13)18(27)23-17(15)24-9-8-14(26)11-24/h1-7,10,14,26H,8-9,11H2	FIVUQIUSDNJTFE-UHFFFAOYSA-N	507971	US11130759, Cpd. No. 145::US11046691, Compound 145::4-((3R)-3-hydroxypyrrolidinyl)-1- phenyl-7-(trifluoromethyl)hydro- quinazolin-2-one::US11084798, Cpd No 145	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507971&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147508681	459093053							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071690	Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C15H10F3N3O/c16-15(17,18)9-6-7-11-12(8-9)21(14(22)20-13(11)19)10-4-2-1-3-5-10/h1-8H,(H2,19,20,22)	RFAOQCTVOYENAY-UHFFFAOYSA-N	507974	US11130759, Cpd. No. 146::US11046691, Compound 146::4-amino-1-phenyl-7-(trifluoromethyl)- hydroquinazolin-2-one::US11084798, Cpd No 146	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507974&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			146721284	459093056							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071691	Cc1ccccc1-n1c2cc(ccc2c(=O)[nH]c1=O)C(F)(F)F |(-1.33,-1.54,;,-2.31,;,-3.85,;1.33,-4.62,;2.67,-3.85,;2.67,-2.31,;1.33,-1.54,;1.33,,;,.77,;-1.33,,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;1.33,3.08,;1.33,4.62,;2.67,2.31,;2.67,.77,;4,,;-4,,;-5.33,.77,;-4,-1.54,;-5.33,-.77,)|	InChI=1S/C16H11F3N2O2/c1-9-4-2-3-5-12(9)21-13-8-10(16(17,18)19)6-7-11(13)14(22)20-15(21)23/h2-8H,1H3,(H,20,22,23)	VAYSYJVXGPABMQ-UHFFFAOYSA-N	507977	US11130759, Cpd. No. 147::US11046691, Compound 147::1-(2-methylphenyl)-7-(trifluoromethyl)- 1,3-dihydroquinazoline-2,4-dione::US11084798, Cpd No 147	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507977&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370670	459093059							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071692	Nc1nc(=O)n(-c2ccccc2Cl)c2cc(Cl)ccc12 |(1.33,4.62,;1.33,3.08,;2.67,2.31,;2.67,.77,;4,,;1.33,,;1.33,-1.54,;2.67,-2.31,;2.67,-3.85,;1.33,-4.62,;,-3.85,;,-2.31,;-1.33,-1.54,;,.77,;-1.33,,;-2.67,.77,;-4,,;-2.67,2.31,;-1.33,3.08,;,2.31,)|	InChI=1S/C14H9Cl2N3O/c15-8-5-6-9-12(7-8)19(14(20)18-13(9)17)11-4-2-1-3-10(11)16/h1-7H,(H2,17,18,20)	JMVVXEDIDTXUGG-UHFFFAOYSA-N	507980	US11130759, Cpd. No. 148::US11046691, Compound 148::4-amino-7-chloro-1-(2-chlorophenyl)- hydroquinazolin-2-one::US11084798, Cpd No 148	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507980&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148085609	459093062							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071693	Nc1nc(=O)n(-c2ccccc2Br)c2cc(Cl)ccc12 |(1.33,4.62,;1.33,3.08,;2.67,2.31,;2.67,.77,;4,,;1.33,,;1.33,-1.54,;2.67,-2.31,;2.67,-3.85,;1.33,-4.62,;,-3.85,;,-2.31,;-1.33,-1.54,;,.77,;-1.33,,;-2.67,.77,;-4,,;-2.67,2.31,;-1.33,3.08,;,2.31,)|	InChI=1S/C14H9BrClN3O/c15-10-3-1-2-4-11(10)19-12-7-8(16)5-6-9(12)13(17)18-14(19)20/h1-7H,(H2,17,18,20)	GHLVKLYLLBREPE-UHFFFAOYSA-N	507983	US11130759, Cpd. No. 149::US11046691, Compound 149::4-amino-1-(2-bromophenyl)-7-chloro- hydroquinazolin-2-one::US11084798, Cpd No 149	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507983&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608360	459093065							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071694	Cc1ccc2c(N)nc(=O)n(-c3ccccc3)c2n1	InChI=1S/C14H12N4O/c1-9-7-8-11-12(15)17-14(19)18(13(11)16-9)10-5-3-2-4-6-10/h2-8H,1H3,(H2,15,17,19)	QNHGLOIZHPJKBB-UHFFFAOYSA-N	507986	US11130759, Cpd. No. 150::US11046691, Compound 150::4-amino-7-methyl-1-phenylhydro- pyridino[2,3-d]pyrimidin-2-one::US11084798, Cpd No 150	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507986&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608402	459093068							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071695	COc1ccccc1-n1c2cc(Cl)ccc2c(nc1=O)N1CC[C@@H](O)C1 |r,wD:23.26,(-2.67,-4.12,;-1.33,-3.35,;,-4.12,;,-5.66,;1.33,-6.43,;2.67,-5.66,;2.67,-4.12,;1.33,-3.35,;1.33,-1.81,;,-1.04,;-1.33,-1.81,;-2.67,-1.04,;-4,-1.81,;-2.67,.5,;-1.33,1.27,;,.5,;1.33,1.27,;2.67,.5,;2.67,-1.04,;4,-1.81,;1.33,2.81,;2.58,3.72,;2.1,5.18,;.56,5.18,;-.34,6.43,;.09,3.72,)|	InChI=1S/C19H18ClN3O3/c1-26-17-5-3-2-4-15(17)23-16-10-12(20)6-7-14(16)18(21-19(23)25)22-9-8-13(24)11-22/h2-7,10,13,24H,8-9,11H2,1H3	KWAMQBDLMCCICJ-UHFFFAOYSA-N	507989	US11130759, Cpd. No. 151::US11046691, Compound 151::4-((3R)-3-hydroxypyrrolidin-1-yl)-7- chloro-1-(2-methoxyphenyl)hydro- quinazolin-2-one::US11084798, Cpd No 151	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507989&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514080	459093071							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071697	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2Cl)c2cc(Cl)ccc12 |r,wD:1.0,(-.34,6.43,;.56,5.18,;2.1,5.18,;2.58,3.72,;1.33,2.81,;.09,3.72,;1.33,1.27,;2.67,.5,;2.67,-1.04,;4,-1.81,;1.33,-1.81,;1.33,-3.35,;2.67,-4.12,;2.67,-5.66,;1.33,-6.43,;,-5.66,;,-4.12,;-1.33,-3.35,;,-1.04,;-1.33,-1.81,;-2.67,-1.04,;-4,-1.81,;-2.67,.5,;-1.33,1.27,;,.5,)|	InChI=1S/C18H15Cl2N3O2/c19-11-5-6-13-16(9-11)23(15-4-2-1-3-14(15)20)18(25)21-17(13)22-8-7-12(24)10-22/h1-6,9,12,24H,7-8,10H2	LJDNULCGRVBJBW-UHFFFAOYSA-N	507941	US11130759, Cpd. No. 153::4-((3R)-3-hydroxypyrrolidin-1-yl)-7- chloro-1-(2-chlorophenyl)hydro- quinazolin-2-one::US11046691, Compound 153::US11046691, Compound 135::US11084798, Cpd No 153	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507941&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148354417	459093023							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071698	Cc1ccccc1-n1c2cc(Cl)ccc2c(N)nc1=O |(-1.33,-1.54,;,-2.31,;,-3.85,;1.33,-4.62,;2.67,-3.85,;2.67,-2.31,;1.33,-1.54,;1.33,,;,.77,;-1.33,,;-2.67,.77,;-4,,;-2.67,2.31,;-1.33,3.08,;,2.31,;1.33,3.08,;1.33,4.62,;2.67,2.31,;2.67,.77,;4,,)|	InChI=1S/C15H12ClN3O/c1-9-4-2-3-5-12(9)19-13-8-10(16)6-7-11(13)14(17)18-15(19)20/h2-8H,1H3,(H2,17,18,20)	LZUQWZNICMYASQ-UHFFFAOYSA-N	507997	US11130759, Cpd. No. 154::US11046691, Compound 154::4-amino-7-chloro-1-(2-methylphenyl)- hydroquinazolin-2-one::US11084798, Cpd No 154	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507997&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608760	459093077							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071699	CNc1nc(=O)n(-c2cccc(c2)C#N)c2cc(Cl)ccc12	InChI=1S/C16H11ClN4O/c1-19-15-13-6-5-11(17)8-14(13)21(16(22)20-15)12-4-2-3-10(7-12)9-18/h2-8H,1H3,(H,19,20,22)	XPDFKEUUSYIYEI-UHFFFAOYSA-N	508000	US11130759, Cpd. No. 155::US11046691, Compound 155::3-[7-chloro-4-(methylamino)-2-oxo- hydroquinazolinyl]benzenecarbonitrile::US11084798, Cpd No 155	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508000&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608440	459093080							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071700	OC(=O)c1cccc(c1)-n1c2cc(Cl)ccc2c(=O)[nH]c1=O	InChI=1S/C15H9ClN2O4/c16-9-4-5-11-12(7-9)18(15(22)17-13(11)19)10-3-1-2-8(6-10)14(20)21/h1-7H,(H,20,21)(H,17,19,22)	NNQBTDOHANJUCY-UHFFFAOYSA-N	508003	US11130759, Cpd. No. 156::US11046691, Compound 156::3-(7-chloro-4-hydroxy-2-oxohydro- quinazolinyl)benzoic acid::US11084798, Cpd No 156	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508003&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370673	459093083							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071701	CNc1nc(=O)n(-c2cccc(O)c2C)c2cc(Cl)ccc12 |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;,-2.69,;,-4.23,;1.33,-5,;2.67,-4.23,;4,-5,;2.67,-2.69,;4,-1.92,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-2.67,1.93,;-1.33,2.69,;,1.93,)|	InChI=1S/C16H14ClN3O2/c1-9-12(4-3-5-14(9)21)20-13-8-10(17)6-7-11(13)15(18-2)19-16(20)22/h3-8,21H,1-2H3,(H,18,19,22)	CMDVVOIUIPMJCC-UHFFFAOYSA-N	508006	US11130759, Cpd. No. 157::US11046691, Compound 157::7-chloro-1-(3-hydroxy-2- methylphenyl)-4- (methylamino)hydroquinazolin-2-one::US11084798, Cpd No 157	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508006&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608653	459093086							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071702	CN(C)C(=O)C1CN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C20H19ClN4O2/c1-23(2)19(26)13-11-24(12-13)18-16-9-8-14(21)10-17(16)25(20(27)22-18)15-6-4-3-5-7-15/h3-10,13H,11-12H2,1-2H3	FIRYIPOLAJCRIA-UHFFFAOYSA-N	511826	US11130759, Cpd. No. 159::US11084798, Cpd No 159::[1-(7-chloro-2-oxo-1-phenylhydro- quinazolin-4-yl)azetidin-3-yl]-N,N- dimethylcarboxamide	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=511826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=511826&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608942	459629078							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071703	CNc1nc(=O)n(-c2ccccc2)c2cc(CCl)ccc12	InChI=1S/C16H14ClN3O/c1-18-15-13-8-7-11(10-17)9-14(13)20(16(21)19-15)12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,18,19,21)	SOTXQFRMPBBMJB-UHFFFAOYSA-N	508012	US11130759, Cpd. No. 160::US11046691, Compound 160::7-(chloromethyl)-4-(methylamino)-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 160	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508012&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609035	459093092							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071704	OC1CN(C1)c1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(1.33,6.48,;1.33,4.94,;2.42,3.85,;1.33,2.76,;.24,3.85,;1.33,1.22,;2.67,.45,;2.67,-1.09,;4,-1.86,;1.33,-1.86,;1.33,-3.4,;,-4.17,;,-5.71,;1.33,-6.48,;2.67,-5.71,;2.67,-4.17,;4,-3.4,;,-1.09,;-1.33,-1.86,;-2.67,-1.09,;-2.67,.45,;-1.33,1.22,;,.45,;-4,-1.86,;-5.33,-1.09,;-4,-3.4,;-5.33,-2.63,)|	InChI=1S/C17H12ClF3N4O2/c18-11-3-1-2-4-12(11)25-15-10(5-6-13(22-15)17(19,20)21)14(23-16(25)27)24-7-9(26)8-24/h1-6,9,26H,7-8H2	CETFYWIXYGIYQO-UHFFFAOYSA-N	508015	US11130759, Cpd. No. 161::US11046691, Compound 161::1-(2-chlorophenyl)-4-(3-hydroxy- azetidinyl)-7-(trifluoromethyl)pyrido- [2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 161	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508015&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608925	459093095							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071705	OC1CN(C1)c1nc(=O)n(-c2cccc(c2)C#N)c2nc(ccc12)C(F)(F)F	InChI=1S/C18H12F3N5O2/c19-18(20,21)14-5-4-13-15(25-8-12(27)9-25)24-17(28)26(16(13)23-14)11-3-1-2-10(6-11)7-22/h1-6,12,27H,8-9H2	UWYFVUAKSCPRJJ-UHFFFAOYSA-N	508018	US11130759, Cpd. No. 162::US11046691, Compound 162::3-(4-(3-hydroxyazetidin-1-yl)-2-oxo-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-1(2H)-yl)benzonitrile::US11084798, Cpd No 162	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508018&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608665	459093098							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071706	Nc1nc(=O)n(-c2ccccc2)c2cc(Br)ccc12	InChI=1S/C14H10BrN3O/c15-9-6-7-11-12(8-9)18(14(19)17-13(11)16)10-4-2-1-3-5-10/h1-8H,(H2,16,17,19)	BGUJMHFNWCPDLW-UHFFFAOYSA-N	508021	US11130759, Cpd. No. 163::US11046691, Compound 163::4-amino-7-bromo-1-phenylhydro- quinazolin-2-one::US11084798, Cpd No 163	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508021&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608734	459093101							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071707	OC1CN(C1)c1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C18H14F3N3O2/c19-18(20,21)11-6-7-14-15(8-11)24(12-4-2-1-3-5-12)17(26)22-16(14)23-9-13(25)10-23/h1-8,13,25H,9-10H2	VNRQENUSWKDOAL-UHFFFAOYSA-N	508024	US11130759, Cpd. No. 164::US11046691, Compound 164::4-(3-hydroxyazetidin-1-yl)-1-phenyl-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 164	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508024&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608735	459093104							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071708	Cc1ccccc1-n1c2nc(ccc2c(nc1=O)N1CC(O)C1)C(F)(F)F |(4,-3.4,;2.67,-4.17,;2.67,-5.71,;1.33,-6.48,;,-5.71,;,-4.17,;1.33,-3.4,;1.33,-1.86,;,-1.09,;-1.33,-1.86,;-2.67,-1.09,;-2.67,.45,;-1.33,1.22,;,.45,;1.33,1.22,;2.67,.45,;2.67,-1.09,;4,-1.86,;1.33,2.76,;2.42,3.85,;1.33,4.94,;1.33,6.48,;.24,3.85,;-4,-1.86,;-5.33,-1.09,;-4,-3.4,;-5.33,-2.63,)|	InChI=1S/C18H15F3N4O2/c1-10-4-2-3-5-13(10)25-16-12(6-7-14(22-16)18(19,20)21)15(23-17(25)27)24-8-11(26)9-24/h2-7,11,26H,8-9H2,1H3	WWXYTAPTDGWHDM-UHFFFAOYSA-N	508027	US11130759, Cpd. No. 165::US11046691, Compound 165::4-(3-hydroxyazetidinyl)-1-(2-methyl- phenyl)-7-(trifluoromethyppyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 165	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508027&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608595	459093107							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071709	FC(F)c1ccc2c(c1)n(-c1ccccc1)c(=O)[nH]c2=O	InChI=1S/C15H10F2N2O2/c16-13(17)9-6-7-11-12(8-9)19(15(21)18-14(11)20)10-4-2-1-3-5-10/h1-8,13H,(H,18,20,21)	PSIPPPZOAKLWLA-UHFFFAOYSA-N	508031	US11130759, Cpd. No. 166::US11046691, Compound 166::7-(difluoromethyl)-1-phenyl-1,3- dihydroquinazoline-2,4-dione::US11084798, Cpd No 166	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508031&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370675	459093111							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071710	Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(1.33,4.62,;1.33,3.08,;2.67,2.31,;2.67,.77,;4,,;1.33,,;1.33,-1.54,;,-2.31,;,-3.85,;1.33,-4.62,;2.67,-3.85,;2.67,-2.31,;4,-1.54,;,.77,;-1.33,,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;-4,,;-5.33,.77,;-4,-1.54,;-5.33,-.77,)|	InChI=1S/C14H8ClF3N4O/c15-8-3-1-2-4-9(8)22-12-7(11(19)21-13(22)23)5-6-10(20-12)14(16,17)18/h1-6H,(H2,19,21,23)	BVNKURJMNQNVAO-UHFFFAOYSA-N	508034	US11130759, Cpd. No. 286::US11046691, Compound 167::4-amino-1-(2-chlorophenyl)-7- (trifluoro-methyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 167	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508034&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608878	459093114							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071711	Nc1nc(=O)n(-c2cccc(c2)C#N)c2nc(ccc12)C(F)(F)F	InChI=1S/C15H8F3N5O/c16-15(17,18)11-5-4-10-12(20)22-14(24)23(13(10)21-11)9-3-1-2-8(6-9)7-19/h1-6H,(H2,20,22,24)	LLVFPFUIFBVIQY-UHFFFAOYSA-N	508037	US11130759, Cpd. No. 168::US11046691, Compound 168::3-(4-amino-2-oxo-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-1(2H)-yl)- benzonitrile::US11084798, Cpd No 168	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508037&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608263	459093117							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071712	Cc1ccccc1-n1c2nc(ccc2c(N)nc1=O)C(F)(F)F |(4,-1.54,;2.67,-2.31,;2.67,-3.85,;1.33,-4.62,;,-3.85,;,-2.31,;1.33,-1.54,;1.33,,;,.77,;-1.33,,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;1.33,3.08,;1.33,4.62,;2.67,2.31,;2.67,.77,;4,,;-4,,;-5.33,.77,;-4,-1.54,;-5.33,-.77,)|	InChI=1S/C15H11F3N4O/c1-8-4-2-3-5-10(8)22-13-9(12(19)21-14(22)23)6-7-11(20-13)15(16,17)18/h2-7H,1H3,(H2,19,21,23)	SHUFIEZMPYMJFI-UHFFFAOYSA-N	508040	US11130759, Cpd. No. 169::US11046691, Compound 169::4-amino-1-(2-methylphenyl)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 169	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508040&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608837	459093120							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071713	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F |r|	InChI=1S/C18H15F3N4O2/c19-18(20,21)14-7-6-13-15(24-9-8-12(26)10-24)23-17(27)25(16(13)22-14)11-4-2-1-3-5-11/h1-7,12,26H,8-10H2	PGZOPGOLOUBEAJ-UHFFFAOYSA-N	508043	US11130759, Cpd. No. 637::US11046691, Compound 637::(R)-4-(3-hydroxypyrrolidin-1-yl)-1- phenyl-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11046691, Compound 170::US11084798, Cpd No 637	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508043&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608617	459093123							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071714	OC1CN(C1)c1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F	InChI=1S/C17H13F3N4O2/c18-17(19,20)13-7-6-12-14(23-8-11(25)9-23)22-16(26)24(15(12)21-13)10-4-2-1-3-5-10/h1-7,11,25H,8-9H2	SGSBPHSXRCYDNS-UHFFFAOYSA-N	508046	US11130759, Cpd. No. 171::US11046691, Compound 171::4-(3-hydroxyazetidin-1-yl)-1-phenyl-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 171	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508046&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608903	459093126							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071715	OC[C@@H]1CCN1c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C18H16ClN3O2/c19-12-6-7-15-16(10-12)22(13-4-2-1-3-5-13)18(24)20-17(15)21-9-8-14(21)11-23/h1-7,10,14,23H,8-9,11H2	KHTCPWCGVVFMGP-UHFFFAOYSA-N	508049	US11130759, Cpd. No. 172::US11046691, Compound 172::(S)-7-chloro-4-(2-(hydroxymethyl)- azetidin-1-yl)-1-phenylquinazolin- 2(1H)-one::US11084798, Cpd No 172	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508049&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514046	459093129							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071716	CNc1nc(=O)n(-c2cccc(C#N)c2C)c2cc(Cl)ccc12 |(2.67,5.39,;1.33,4.62,;1.33,3.08,;2.67,2.31,;2.67,.77,;4,,;1.33,,;1.33,-1.54,;2.67,-2.31,;2.67,-3.85,;1.33,-4.62,;,-3.85,;-1.33,-4.62,;-2.67,-5.39,;,-2.31,;-1.33,-1.54,;,.77,;-1.33,,;-2.67,.77,;-4,,;-2.67,2.31,;-1.33,3.08,;,2.31,)|	InChI=1S/C17H13ClN4O/c1-10-11(9-19)4-3-5-14(10)22-15-8-12(18)6-7-13(15)16(20-2)21-17(22)23/h3-8H,1-2H3,(H,20,21,23)	MFVUZZRNXUYYNP-UHFFFAOYSA-N	508052	US11130759, Cpd. No. 173::US11046691, Compound 173::3-[7-chloro-4-(methylamino)-2-oxo- hydroquinazolinyl]-2-methylbenzene- carbonitrile::US11084798, Cpd No 173	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508052&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514059	459093132							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071717	CNc1nc(=O)n(-c2cc(ccc2C)C#N)c2cc(Cl)ccc12 |(2,5.39,;.67,4.62,;.67,3.08,;2,2.31,;2,.77,;3.33,,;.67,,;.67,-1.54,;2,-2.31,;2,-3.85,;.67,-4.62,;-.67,-3.85,;-.67,-2.31,;-2,-1.54,;3.33,-4.62,;4.67,-5.39,;-.67,.77,;-2,,;-3.33,.77,;-4.67,,;-3.33,2.31,;-2,3.08,;-.67,2.31,)|	InChI=1S/C17H13ClN4O/c1-10-3-4-11(9-19)7-14(10)22-15-8-12(18)5-6-13(15)16(20-2)21-17(22)23/h3-8H,1-2H3,(H,20,21,23)	AYAMOVWNSKSXDJ-UHFFFAOYSA-N	508055	US11130759, Cpd. No. 174::US11046691, Compound 174::3-(7-chloro-4-(methylamino)-2-oxo- quinazolin-1(2H)-yl)-2-methyl- benzonitrile::US11084798, Cpd No 174	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508055&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147033386	459093135							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071718	CNC(=O)c1cccc(c1)-n1c2cc(Cl)ccc2c(NC)nc1=O	InChI=1S/C17H15ClN4O2/c1-19-15-13-7-6-11(18)9-14(13)22(17(24)21-15)12-5-3-4-10(8-12)16(23)20-2/h3-9H,1-2H3,(H,20,23)(H,19,21,24)	RKXONLBFGXULCW-UHFFFAOYSA-N	508058	US11130759, Cpd. No. 175::US11046691, Compound 175::3-(7-chloro-4-(methylamino)-2-oxo- quinazolin-1(2H)-yl)benzamide::US11084798, Cpd No 175	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508058&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			146741550	459093138							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071719	FC(F)(F)c1ccc2c(nc(=O)n(-c3ccccc3Cl)c2n1)N1CCCC1 |(-5.33,-.41,;-4,-1.18,;-4,-2.72,;-5.33,-1.95,;-2.67,-.41,;-2.67,1.13,;-1.33,1.9,;,1.13,;1.33,1.9,;2.67,1.13,;2.67,-.41,;4,-1.18,;1.33,-1.18,;1.33,-2.72,;,-3.49,;,-5.03,;1.33,-5.8,;2.67,-5.03,;2.67,-3.49,;4,-2.72,;,-.41,;-1.33,-1.18,;1.33,3.44,;2.58,4.34,;2.1,5.8,;.56,5.8,;.09,4.34,)|	InChI=1S/C18H14ClF3N4O/c19-12-5-1-2-6-13(12)26-16-11(7-8-14(23-16)18(20,21)22)15(24-17(26)27)25-9-3-4-10-25/h1-2,5-8H,3-4,9-10H2	XJSWVQIUQPZWLE-UHFFFAOYSA-N	508061	US11130759, Cpd. No. 176::US11046691, Compound 176::1-(2-chlorophenyl)-4-(pyrrolictin-1-yl)- 7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 176	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508061&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149227941	459093141							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071720	FC(F)(F)c1ccc2c(nc(=O)n(-c3cccc(c3)C#N)c2n1)N1CCCC1	InChI=1S/C19H14F3N5O/c20-19(21,22)15-7-6-14-16(26-8-1-2-9-26)25-18(28)27(17(14)24-15)13-5-3-4-12(10-13)11-23/h3-7,10H,1-2,8-9H2	ZYOBJASFHWJUPF-UHFFFAOYSA-N	508064	US11130759, Cpd. No. 177::US11046691, Compound 177::3-(2-oxo-4-(pyrrolidin-1-yl)-7- (trifluoro-methyl)pyrido[2,3- d]pyrimidin-1(2H)-yl)benzonitrile::US11084798, Cpd No 177	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508064&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149594523	459093144							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071721	CNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(2.82,4.19,;1.45,3.5,;1.37,1.96,;2.66,1.12,;2.58,-.42,;3.87,-1.26,;1.21,-1.12,;1.13,-2.66,;-.24,-3.36,;-.32,-4.89,;.97,-5.73,;2.34,-5.03,;2.42,-3.5,;3.79,-2.8,;-.08,-.28,;-1.45,-.98,;-2.74,-.14,;-2.66,1.4,;-1.29,2.1,;,1.26,;-4.12,-.84,;-5.41,-0,;-4.2,-2.38,;-5.49,-1.54,)|	InChI=1S/C15H10ClF3N4O/c1-20-12-8-6-7-11(15(17,18)19)21-13(8)23(14(24)22-12)10-5-3-2-4-9(10)16/h2-7H,1H3,(H,20,22,24)	DRPUHIIWNZBMQN-UHFFFAOYSA-N	508023	US11130759, Cpd. No. 379::US11046691, Compound 379::1-(2-chlorophenyl)-4-((methyl-d3)- amino)-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 178	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508023&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147416416	459093103							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071722	CNc1nc(=O)n(-c2cccc(c2)C#N)c2nc(ccc12)C(F)(F)F	InChI=1S/C16H10F3N5O/c1-21-13-11-5-6-12(16(17,18)19)22-14(11)24(15(25)23-13)10-4-2-3-9(7-10)8-20/h2-7H,1H3,(H,21,23,25)	BVKBEDIMPQITHY-UHFFFAOYSA-N	508070	US11130759, Cpd. No. 179::US11046691, Compound 179::3-[4-(methylamino)-2-oxo-7-(trifluoro- methyl)pyrido[2,3-d]pyrimidin-1(2H)- yl)benzonitrile::US11084798, Cpd No 179	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508070&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608549	459093150							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071723	CNc1nc(=O)n(-c2ccccc2C)c2nc(ccc12)C(F)(F)F |(2.67,4.23,;1.33,3.47,;1.33,1.93,;2.67,1.15,;2.67,-.38,;4,-1.15,;1.33,-1.15,;1.33,-2.69,;,-3.47,;,-5,;1.33,-5.78,;2.67,-5,;2.67,-3.47,;4,-2.69,;,-.38,;-1.33,-1.15,;-2.67,-.38,;-2.67,1.16,;-1.33,1.93,;,1.16,;-4,-1.15,;-5.33,-.38,;-4,-2.69,;-5.33,-1.92,)|	InChI=1S/C16H13F3N4O/c1-9-5-3-4-6-11(9)23-14-10(13(20-2)22-15(23)24)7-8-12(21-14)16(17,18)19/h3-8H,1-2H3,(H,20,22,24)	FXODBRHLYUSETA-UHFFFAOYSA-N	508025	US11130759, Cpd. No. 272::US11046691, Compound 272::4-((methyl-d3)amino)-1-(2-methyl- phenyl)-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 272	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508025&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608569	459093105							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071724	O[C@H]1CCN(C1)c1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.0,(-.34,6.43,;.56,5.18,;2.1,5.18,;2.58,3.72,;1.33,2.81,;.09,3.72,;1.33,1.27,;2.67,.5,;2.67,-1.04,;4,-1.81,;1.33,-1.81,;1.33,-3.35,;,-4.12,;,-5.66,;1.33,-6.43,;2.67,-5.66,;2.67,-4.12,;4,-3.35,;,-1.04,;-1.33,-1.81,;-2.67,-1.04,;-2.67,.5,;-1.33,1.27,;,.5,;-4,-1.81,;-5.33,-1.04,;-4,-3.35,;-5.33,-2.58,)|	InChI=1S/C18H14ClF3N4O2/c19-12-3-1-2-4-13(12)26-16-11(5-6-14(23-16)18(20,21)22)15(24-17(26)28)25-8-7-10(27)9-25/h1-6,10,27H,7-9H2	JZQGFPACQLPTMU-UHFFFAOYSA-N	508076	US11130759, Cpd. No. 181::US11046691, Compound 181::(S)-1-(2-chlorophenyl)-4-(3-hydroxy- pyrrolidin-1-yl)-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 181	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508076&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608596	459093156							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071725	O[C@H]1CCN(C1)c1nc(=O)n(-c2cccc(c2)C#N)c2nc(ccc12)C(F)(F)F |r|	InChI=1S/C19H14F3N5O2/c20-19(21,22)15-5-4-14-16(26-7-6-13(28)10-26)25-18(29)27(17(14)24-15)12-3-1-2-11(8-12)9-23/h1-5,8,13,28H,6-7,10H2	OONLPIYSXWCOAZ-UHFFFAOYSA-N	508079	US11130759, Cpd. No. 182::US11046691, Compound 182::(S)-3-(4-(3-hydroxypyrrolidin-1-yl)-2- oxo-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-1(2H)-yl)benzonitrile::US11084798, Cpd No 182	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508079&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608491	459093159							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071726	Cc1ccccc1-n1c2nc(ccc2c(nc1=O)N1CC[C@@H](O)C1)C(F)(F)F |r,wD:21.24,(4,-3.35,;2.67,-4.12,;2.67,-5.66,;1.33,-6.43,;,-5.66,;,-4.12,;1.33,-3.35,;1.33,-1.81,;,-1.04,;-1.33,-1.81,;-2.67,-1.04,;-2.67,.5,;-1.33,1.27,;,.5,;1.33,1.27,;2.67,.5,;2.67,-1.04,;4,-1.81,;1.33,2.81,;2.58,3.72,;2.1,5.18,;.56,5.18,;-.34,6.43,;.09,3.72,;-4,-1.81,;-5.33,-1.04,;-4,-3.35,;-5.33,-2.58,)|	InChI=1S/C19H17F3N4O2/c1-11-4-2-3-5-14(11)26-17-13(6-7-15(23-17)19(20,21)22)16(24-18(26)28)25-9-8-12(27)10-25/h2-7,12,27H,8-10H2,1H3	ZFEFRIQBVZNPPE-UHFFFAOYSA-N	508082	US11130759, Cpd. No. 183::US11046691, Compound 183::(R)-4-(3-hydroxypyrrolidin-1-yl)-1-(o- tolyl)-7-(trifluoromethyl)pyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 183	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508082	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508082&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514049	459093162							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071727	CNc1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F	InChI=1S/C15H11F3N4O/c1-19-12-10-7-8-11(15(16,17)18)20-13(10)22(14(23)21-12)9-5-3-2-4-6-9/h2-8H,1H3,(H,19,21,23)	NSPRCNZXZORNPC-UHFFFAOYSA-N	507985	US11130759, Cpd. No. 366::4-((methyl-d3)amino)-1-phenyl-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11046691, Compound 184::US11046691, Compound 366::US11084798, Cpd No 184	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507985&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148686497	459093067							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071728	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(OCCO)c12	InChI=1S/C17H16ClN3O3/c1-19-16-15-13(9-11(18)10-14(15)24-8-7-22)21(17(23)20-16)12-5-3-2-4-6-12/h2-6,9-10,22H,7-8H2,1H3,(H,19,20,23)	KLYGOWMSXOLBLX-UHFFFAOYSA-N	508087	US11130759, Cpd. No. 185::US11046691, Compound 185::7-chloro-5-(2-hydroxyethoxy)-4- (methylamino)-1-phenylhydro- quinazolin-2-one::US11084798, Cpd No 185	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508087&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608401	459093166							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071729	OCC1CCN1c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |w:2.1|	InChI=1S/C18H16ClN3O2/c19-12-6-7-15-16(10-12)22(13-4-2-1-3-5-13)18(24)20-17(15)21-9-8-14(21)11-23/h1-7,10,14,23H,8-9,11H2	KHTCPWCGVVFMGP-UHFFFAOYSA-N	508090	US11130759, Cpd. No. 186::US11046691, Compound 186::7-chloro-4-[2-(hydroxymethyl)azetidin- 1-yl]-1-phenylhydroquinazolin-2-one::US11084798, Cpd No 186	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508090&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608486	459093169							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071730	OC[C@H]1CCN1c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C18H16ClN3O2/c19-12-6-7-15-16(10-12)22(13-4-2-1-3-5-13)18(24)20-17(15)21-9-8-14(21)11-23/h1-7,10,14,23H,8-9,11H2	KHTCPWCGVVFMGP-UHFFFAOYSA-N	508093	US11130759, Cpd. No. 187::US11046691, Compound 187::(R)-7-chloro-4-(2-(hydroxymethyl)- azetidin-1-yl)-1-phenylquinazolin- 2(1H)-one::US11084798, Cpd No 187	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508093&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608828	459093172							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071731	CNc1nc(=O)n(-c2nccn2C)c2cc(Cl)ccc12 |(2.65,4.65,;1.31,3.88,;1.31,2.34,;2.65,1.57,;2.65,.03,;3.98,-.74,;1.31,-.74,;1.31,-2.28,;.07,-3.19,;.54,-4.65,;2.08,-4.65,;2.56,-3.19,;4.02,-2.71,;-.02,.03,;-1.36,-.74,;-2.69,.03,;-4.02,-.74,;-2.69,1.57,;-1.36,2.34,;-.02,1.57,)|	InChI=1S/C13H12ClN5O/c1-15-11-9-4-3-8(14)7-10(9)19(13(20)17-11)12-16-5-6-18(12)2/h3-7H,1-2H3,(H,15,17,20)	RMQHLCWEYDKKBK-UHFFFAOYSA-N	507792	US11130759, Cpd. No. 188::US11046691, Compound 188::7-chloro-4-(methylamino)-1-(1-methyl- imidazol-2-yphydroquinazolin-2-one::US11084798, Cpd No 188	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507792&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933660	459092877							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071732	CO[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C19H18ClN3O2/c1-25-15-9-10-22(12-15)18-16-8-7-13(20)11-17(16)23(19(24)21-18)14-5-3-2-4-6-14/h2-8,11,15H,9-10,12H2,1H3	QVDAMNRNSWSMMY-UHFFFAOYSA-N	508098	US11130759, Cpd. No. 189::US11046691, Compound 189::(R)-7-chloro-4-(3-methoxypyrrolidin-1- yl)-1-phenylquinazolin-2(1H)-one::US11084798, Cpd No 189	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508098&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608622	459093177							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071733	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)c(cc12)C#N	InChI=1S/C16H11ClN4O/c1-19-15-12-7-10(9-18)13(17)8-14(12)21(16(22)20-15)11-5-3-2-4-6-11/h2-8H,1H3,(H,19,20,22)	BNCDXVICLDDKIQ-UHFFFAOYSA-N	508101	US11130759, Cpd. No. 190::US11046691, Compound 190::7-chloro-4-(methylamino)-2-oxo-1- phenylhydroquinazoline-6-carbonitrile::US11084798, Cpd No 190	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508101&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608437	459093180							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071734	Clc1ccc2cnc(=O)n(-c3ccccc3)c2c1	InChI=1S/C14H9ClN2O/c15-11-7-6-10-9-16-14(18)17(13(10)8-11)12-4-2-1-3-5-12/h1-9H	LJXFZDDSOQHLTL-UHFFFAOYSA-N	508103	US11130759, Cpd. No. 191::US11046691, Compound 191::7-chloro-1-phenylhydroquinazolin-2- one::US11084798, Cpd No 191	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508103&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608264	459093182							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071735	CNc1nc(=O)n(-c2ccccc2)c2cc(C)cnc12	InChI=1S/C15H14N4O/c1-10-8-12-13(17-9-10)14(16-2)18-15(20)19(12)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,16,18,20)	ZTBKXPYIVAPANS-UHFFFAOYSA-N	508106	US11130759, Cpd. No. 192::US11046691, Compound 192::7-methyl-4-(methylamino)-1-phenyl- pyrido[3,2-d]pyrimidin-2(1H)-one::US11084798, Cpd No 192	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508106&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608779	459093185							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071736	Cc1cnc2c(c1)n(-c1ccccc1)c(=O)[nH]c2=O	InChI=1S/C14H11N3O2/c1-9-7-11-12(15-8-9)13(18)16-14(19)17(11)10-5-3-2-4-6-10/h2-8H,1H3,(H,16,18,19)	DLPLUWJAWAUCEA-UHFFFAOYSA-N	508109	US11130759, Cpd. No. 193::US11046691, Compound 193::7-methyl-1-phenylpyrido[3,2-d]- pyrimidine-2,4(1H,3H)-dione::US11084798, Cpd No 193	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508109&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370677	459093188							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071737	Cc1ncc2c(n1)n(-c1ccccc1)c(=O)[nH]c2=O	InChI=1S/C13H10N4O2/c1-8-14-7-10-11(15-8)17(13(19)16-12(10)18)9-5-3-2-4-6-9/h2-7H,1H3,(H,16,18,19)	RUDVTQLRBDZJBC-UHFFFAOYSA-N	508112	US11130759, Cpd. No. 194::US11046691, Compound 194::7-methyl-1-phenylpyrimido[4,5-d]- pyrimidine-2,4(1H,3H)-dione::US11084798, Cpd No 194	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508112&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370678	459093191							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071738	OC(=O)[C@@H]1CCCN1c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C19H16ClN3O3/c20-12-8-9-14-16(11-12)23(13-5-2-1-3-6-13)19(26)21-17(14)22-10-4-7-15(22)18(24)25/h1-3,5-6,8-9,11,15H,4,7,10H2,(H,24,25)	AGVZPFXZWQZJFR-UHFFFAOYSA-N	508115	US11130759, Cpd. No. 195::US11046691, Compound 195::(2S)-1-(7-chloro-2-oxo-1-phenylhydro- quinazolin-4-yl)pyrrolidine-2- carboxylic acid::US11084798, Cpd No 195	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508115&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609022	459093194							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071739	CO[C@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C19H18ClN3O2/c1-25-15-9-10-22(12-15)18-16-8-7-13(20)11-17(16)23(19(24)21-18)14-5-3-2-4-6-14/h2-8,11,15H,9-10,12H2,1H3	QVDAMNRNSWSMMY-UHFFFAOYSA-N	507783	US11130759, Cpd. No. 196::US11046691, Compound 196::(S)-7-chloro-4-(3-methoxypyrrolidin-1- yl)-1-phenylquinazolin-2(1H)-one::US11084798, Cpd No 196	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507783&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609069	459092868							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071740	CN(Cc1ccccc1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C22H18ClN3O/c1-25(15-16-8-4-2-5-9-16)21-19-13-12-17(23)14-20(19)26(22(27)24-21)18-10-6-3-7-11-18/h2-14H,15H2,1H3	PAEYAOVIVDMVSC-UHFFFAOYSA-N	507787	US11130759, Cpd. No. 197::US11046691, Compound 197::7-chloro-4-[methylbenzylamino]-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 197	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507787&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609063	459092872							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071741	CNc1nc(=O)n(-c2nccn2C)c2cc(Cl)ccc12 |(2.65,4.65,;1.31,3.88,;1.31,2.34,;2.65,1.57,;2.65,.03,;3.98,-.74,;1.31,-.74,;1.31,-2.28,;.07,-3.19,;.54,-4.65,;2.08,-4.65,;2.56,-3.19,;4.02,-2.71,;-.02,.03,;-1.36,-.74,;-2.69,.03,;-4.02,-.74,;-2.69,1.57,;-1.36,2.34,;-.02,1.57,)|	InChI=1S/C13H12ClN5O/c1-15-11-9-4-3-8(14)7-10(9)19(13(20)17-11)12-16-5-6-18(12)2/h3-7H,1-2H3,(H,15,17,20)	RMQHLCWEYDKKBK-UHFFFAOYSA-N	507792	US11130759, Cpd. No. 188::US11046691, Compound 188::7-chloro-4-(methylamino)-1-(1-methyl- imidazol-2-yphydroquinazolin-2-one::US11084798, Cpd No 188	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507792&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933660	459092877							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071742	COC(=O)C1CN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C19H16ClN3O3/c1-26-18(24)12-10-22(11-12)17-15-8-7-13(20)9-16(15)23(19(25)21-17)14-5-3-2-4-6-14/h2-9,12H,10-11H2,1H3	DBOQCVJVWRDNDU-UHFFFAOYSA-N	507796	US11130759, Cpd. No. 199::US11046691, Compound 199::methyl 1-(7-chloro-2-oxo-1-phenyl-1,2- dihydroquinazolin-4-yl)azetidine-3- carboxylate::US11084798, Cpd No 199	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507796&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514202	459092881							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071743	CS(=O)(=O)Nc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C15H12ClN3O3S/c1-23(21,22)18-14-12-8-7-10(16)9-13(12)19(15(20)17-14)11-5-3-2-4-6-11/h2-9H,1H3,(H,17,18,20)	CZTGQRVKSPNOIT-UHFFFAOYSA-N	507800	US11130759, Cpd. No. 200::US11046691, Compound 200::N-(7-chloro-2-oxo-1-phenyl-1,2- dihydroquinazolin-4-yl)methane- sulfonamide::US11084798, Cpd No 200	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507800&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608349	459092885							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071744	NC1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |w:1.0|	InChI=1S/C18H17ClN4O/c19-12-6-7-15-16(10-12)23(14-4-2-1-3-5-14)18(24)21-17(15)22-9-8-13(20)11-22/h1-7,10,13H,8-9,11,20H2	BTBIALXDKVPIJY-UHFFFAOYSA-N	507804	US11130759, Cpd. No. 201::US11046691, Compound 201::4-(3-aminopyrrolidin-1-yl)-7-chloro-1- phenylquinazolin-2(1H)-one::US11084798, Cpd No 201	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507804&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608220	459092889							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071745	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(OC3COC3)c12	InChI=1S/C18H16ClN3O3/c1-20-17-16-14(7-11(19)8-15(16)25-13-9-24-10-13)22(18(23)21-17)12-5-3-2-4-6-12/h2-8,13H,9-10H2,1H3,(H,20,21,23)	DSZDTGLNTXPIDA-UHFFFAOYSA-N	507808	US11130759, Cpd. No. 202::US11046691, Compound 202::7-chloro-4-(methylamino)-5-oxetan-3- yloxy-1-phenylhydroquinazolin-2-one::US11084798, Cpd No 202	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507808&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608823	459092893							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071746	CC(=O)Nc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C16H12ClN3O2/c1-10(21)18-15-13-8-7-11(17)9-14(13)20(16(22)19-15)12-5-3-2-4-6-12/h2-9H,1H3,(H,18,19,21,22)	BMUHXQXBOHBUQJ-UHFFFAOYSA-N	507812	US11130759, Cpd. No. 203::US11046691, Compound 203::N-(7-chloro-2-oxo-1-phenyl-1,2- dihydroquinazolin-4-yl)acetamide::US11084798, Cpd No 203	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507812&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608708	459092897							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071747	CNC(=O)C1CN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C19H17ClN4O2/c1-21-18(25)12-10-23(11-12)17-15-8-7-13(20)9-16(15)24(19(26)22-17)14-5-3-2-4-6-14/h2-9,12H,10-11H2,1H3,(H,21,25)	IDRRRHSSQPCQOV-UHFFFAOYSA-N	507816	US11130759, Cpd. No. 204::US11046691, Compound 204::1-(7-chloro-2-oxo-1-phenyl-1,2- dihydroquinazolin-4-yl)-N-methyl- azetidine-3-carboxamide::US11084798, Cpd No 204	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507816&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608999	459092901							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071748	CN(CC(F)F)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C17H14ClF2N3O/c1-22(10-15(19)20)16-13-8-7-11(18)9-14(13)23(17(24)21-16)12-5-3-2-4-6-12/h2-9,15H,10H2,1H3	CAAKXCCGMNMPCU-UHFFFAOYSA-N	507820	US11130759, Cpd. No. 205::US11046691, Compound 205::4-[(2,2-difluoroethyl)methylamino]-7- chloro-1-phenylhydroquinazolin-2-one::US11084798, Cpd No 205	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507820&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608470	459092905							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071749	Clc1ccc2c(nc(=O)n(-c3ccccc3)c2c1)N1CCC1=O	InChI=1S/C17H12ClN3O2/c18-11-6-7-13-14(10-11)21(12-4-2-1-3-5-12)17(23)19-16(13)20-9-8-15(20)22/h1-7,10H,8-9H2	LCPBOVLHJWOWKR-UHFFFAOYSA-N	507823	US11130759, Cpd. No. 206::US11046691, Compound 206::7-chloro-4-(2-oxoazetidin-1-yl)-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 206	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507823&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608609	459092908							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071750	FC1(F)CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C18H14ClF2N3O/c19-12-6-7-14-15(10-12)24(13-4-2-1-3-5-13)17(25)22-16(14)23-9-8-18(20,21)11-23/h1-7,10H,8-9,11H2	UCQOIXKXEDCQOA-UHFFFAOYSA-N	507827	US11130759, Cpd. No. 207::US11046691, Compound 207::4-(3,3-difluoropyrrolidin-1-yl)-7- chloro-1-phenylhydroquinazolin-2-one::US11084798, Cpd No 207	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507827&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609002	459092912							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071751	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(-n3cccn3)c12	InChI=1S/C18H14ClN5O/c1-20-17-16-14(23-9-5-8-21-23)10-12(19)11-15(16)24(18(25)22-17)13-6-3-2-4-7-13/h2-11H,1H3,(H,20,22,25)	YEXTXIIBRHNAFS-UHFFFAOYSA-N	507831	US11130759, Cpd. No. 208::US11046691, Compound 208::7-chloro-4-(methylamino)-1-phenyl-5- (1H-pyrazol-1-yl)quinazolin-2(1H)-one::US11084798, Cpd No 208	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507831&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608761	459092916							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071752	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(-n3nccn3)c12	InChI=1S/C17H13ClN6O/c1-19-16-15-13(9-11(18)10-14(15)24-20-7-8-21-24)23(17(25)22-16)12-5-3-2-4-6-12/h2-10H,1H3,(H,19,22,25)	FHZGMMDONFRMGG-UHFFFAOYSA-N	507834	US11130759, Cpd. No. 209::US11046691, Compound 209::7-chloro-4-(methylamino)-1-phenyl-5- (1,2,3-triazol-2-yl)quinazolin-2(1H)- one::US11084798, Cpd No 209	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507834&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608640	459092919							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071753	Oc1ccnc(n1)-n1c2cc(Cl)ccc2c(=O)[nH]c1=O	InChI=1S/C12H7ClN4O3/c13-6-1-2-7-8(5-6)17(12(20)16-10(7)19)11-14-4-3-9(18)15-11/h1-5H,(H,14,15,18)(H,16,19,20)	FUSPPFRAYLLOHT-UHFFFAOYSA-N	507838	US11130759, Cpd. No. 210::US11046691, Compound 210::7-chloro-1-(4-hydroxypyrimidin-2-yl)- 1,3-dihydroquinazoline-2,4-dione::US11084798, Cpd No 210	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507838&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370650	459092923							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071754	CN(C)c1nc(=O)n(-c2cccc(NS(=O)(=O)C3(C)CC3)c2)c2cc(Cl)ccc12	InChI=1S/C20H21ClN4O3S/c1-20(9-10-20)29(27,28)23-14-5-4-6-15(12-14)25-17-11-13(21)7-8-16(17)18(24(2)3)22-19(25)26/h4-8,11-12,23H,9-10H2,1-3H3	AALSWYDZKJIIAQ-UHFFFAOYSA-N	507842	US11130759, Cpd. No. 211::US11046691, Compound 211::4-(dimethylamino)-7-chloro-1-(3- {[(methylcyclopropyl)sulfonyl]a- mino(phenyl)-hydroquinazolin-2-one::US11084798, Cpd No 211	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507842&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933507	459092927							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071755	OCc1ccc2c(c1)n(-c1ccccc1)c(=O)[nH]c2=O	InChI=1S/C15H12N2O3/c18-9-10-6-7-12-13(8-10)17(15(20)16-14(12)19)11-4-2-1-3-5-11/h1-8,18H,9H2,(H,16,19,20)	MFSFUIGEUOMGTE-UHFFFAOYSA-N	507846	US11130759, Cpd. No. 212::US11046691, Compound 212::7-(hydroxymethyl)-1-phenyl-1,3- dihydroquinazoline-2,4-dione::US11084798, Cpd No 212	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507846&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370651	459092931							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071756	CCOC(=O)c1ccc2c(c1)n(-c1ccccc1)c(=O)[nH]c2=O	InChI=1S/C17H14N2O4/c1-2-23-16(21)11-8-9-13-14(10-11)19(17(22)18-15(13)20)12-6-4-3-5-7-12/h3-10H,2H2,1H3,(H,18,20,22)	KNFVIVVKRXUOIJ-UHFFFAOYSA-N	507849	US11130759, Cpd. No. 213::US11046691, Compound 213::ethyl 2,4-dioxo-1-phenyl-1,3-dihydro- quinazoline-7-carboxylate::US11084798, Cpd No 213	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507849&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370652	459092934							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071757	CNc1nc(=O)n(-c2ccn[nH]2)c2cc(Cl)ccc12	InChI=1S/C12H10ClN5O/c1-14-11-8-3-2-7(13)6-9(8)18(12(19)16-11)10-4-5-15-17-10/h2-6H,1H3,(H,15,17)(H,14,16,19)	OOCOROCQCBNMAL-UHFFFAOYSA-N	507852	US11130759, Cpd. No. 214::US11046691, Compound 214::7-chloro-4-(methylamino)-1-pyrazol-5- ylhydroquinazolin-2-one::US11084798, Cpd No 214	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507852&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148801484	459092937							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071758	Cn1ccnc1-n1c2cc(Cl)ccc2c(=O)[nH]c1=O |(3.97,-2.4,;2.49,-2.83,;1.97,-4.28,;.43,-4.22,;0,-2.74,;1.28,-1.88,;1.33,-.34,;.03,.47,;-1.33,-.25,;-2.64,.57,;-4,-.16,;-2.59,2.11,;-1.23,2.83,;.08,2.01,;1.44,2.74,;1.49,4.28,;2.75,1.92,;2.69,.38,;4,-.43,)|	InChI=1S/C12H9ClN4O2/c1-16-5-4-14-11(16)17-9-6-7(13)2-3-8(9)10(18)15-12(17)19/h2-6H,1H3,(H,15,18,19)	QCMLXGQGIWLNJZ-UHFFFAOYSA-N	507855	US11130759, Cpd. No. 215::US11046691, Compound 215::7-chloro-1-(1-methylimidazol-2-yl)-1,3- dihydroquinazoline-2,4-dione::US11084798, Cpd No 215	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507855&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370654	459092940							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071759	C[C@]1(O)CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C19H18ClN3O2/c1-19(25)9-10-22(12-19)17-15-8-7-13(20)11-16(15)23(18(24)21-17)14-5-3-2-4-6-14/h2-8,11,25H,9-10,12H2,1H3	RLUCABKWIJKYBY-UHFFFAOYSA-N	507858	US11130759, Cpd. No. 216::US11046691, Compound 216::4-((3S)-3-hydroxy-3-methylpyrrolidin- 1-yl)-7-chloro-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 216	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507858&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608711	459092943							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071760	C[C@@]1(O)CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C19H18ClN3O2/c1-19(25)9-10-22(12-19)17-15-8-7-13(20)11-16(15)23(18(24)21-17)14-5-3-2-4-6-14/h2-8,11,25H,9-10,12H2,1H3	RLUCABKWIJKYBY-UHFFFAOYSA-N	507861	US11130759, Cpd. No. 217::US11046691, Compound 217::4-((3R)-3-hydroxy-3-methylpyrrolidin- 1-yl)-7-chloro-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 217	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507861&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933486	459092945							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071761	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(Cl)ccc12 |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.39,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.92,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-2.67,1.93,;-1.33,2.69,;,1.92,)|	InChI=1S/C15H11Cl2N3O/c1-18-14-10-7-6-9(16)8-13(10)20(15(21)19-14)12-5-3-2-4-11(12)17/h2-8H,1H3,(H,18,19,21)	WLCVLMQIELQLLD-UHFFFAOYSA-N	507864	US11130759, Cpd. No. 347::US11046691, Compound 218::7-chloro-1-(2-chlorophenyl)-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 218	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507864&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152279906	459092948							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071762	CNc1nc(=O)n(-c2ccccc2C#N)c2cc(Cl)ccc12 |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.39,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.92,;-2.67,-1.15,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-2.67,1.93,;-1.33,2.69,;,1.92,)|	InChI=1S/C16H11ClN4O/c1-19-15-12-7-6-11(17)8-14(12)21(16(22)20-15)13-5-3-2-4-10(13)9-18/h2-8H,1H3,(H,19,20,22)	FAWJJTKIMWCCFP-UHFFFAOYSA-N	507867	US11130759, Cpd. No. 219::US11046691, Compound 219::2-(7-chloro-4-(methylamino)-2-oxo- quinazolin-1(2H)-yl)benzonitrile::US11084798, Cpd No 219	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507867&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608585	459092951							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071763	CN(C)C(=O)CN(C)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C19H19ClN4O2/c1-22(2)17(25)12-23(3)18-15-10-9-13(20)11-16(15)24(19(26)21-18)14-7-5-4-6-8-14/h4-11H,12H2,1-3H3	RTXCMVLZZKPBNY-UHFFFAOYSA-N	507870	US11130759, Cpd. No. 220::US11046691, Compound 220::2-((7-chloro-2-oxo-1-phenyl-1,2- dihydroquinazolin-4- yl)(methyl)amino)-N,N- dimethylacetamide::US11084798, Cpd No 220	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507870&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609055	459092954							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071764	CNC(=O)CN(C)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C18H17ClN4O2/c1-20-16(24)11-22(2)17-14-9-8-12(19)10-15(14)23(18(25)21-17)13-6-4-3-5-7-13/h3-10H,11H2,1-2H3,(H,20,24)	ARUHQBAOVMRAKS-UHFFFAOYSA-N	507873	US11130759, Cpd. No. 221::US11046691, Compound 221::2-((7-chloro-2-oxo-1-phenyl-1,2- dihydroquinazolin-4- yl)(methyl)amino)-,N-methylacetamide::US11084798, Cpd No 221	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507873&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609062	459092957							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071765	Clc1ccc2c(nc(=O)n(-c3ccccc3)c2c1)N1CC2CC2C1	InChI=1S/C19H16ClN3O/c20-14-6-7-16-17(9-14)23(15-4-2-1-3-5-15)19(24)21-18(16)22-10-12-8-13(12)11-22/h1-7,9,12-13H,8,10-11H2	KZCGCMIRGHNYKS-UHFFFAOYSA-N	507876	US11130759, Cpd. No. 222::US11046691, Compound 222::4-(3-azabicyclo[3.1.0]hex-3-yl)-7- chloro-1-phenylhydroquinazolin-2-one::US11084798, Cpd No 222	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507876&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608728	459092960							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071766	CC1CCN1c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |w:1.0|	InChI=1S/C18H16ClN3O/c1-12-9-10-21(12)17-15-8-7-13(19)11-16(15)22(18(23)20-17)14-5-3-2-4-6-14/h2-8,11-12H,9-10H2,1H3	IUWNECLIDRHDKK-UHFFFAOYSA-N	507879	US11130759, Cpd. No. 223::US11046691, Compound 223::7-chloro-4-(2-methylazetidin-1-yl)-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 223	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507879&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608445	459092963							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071767	OC(=O)[C@H]1CCCN1c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C19H16ClN3O3/c20-12-8-9-14-16(11-12)23(13-5-2-1-3-6-13)19(26)21-17(14)22-10-4-7-15(22)18(24)25/h1-3,5-6,8-9,11,15H,4,7,10H2,(H,24,25)	AGVZPFXZWQZJFR-UHFFFAOYSA-N	507882	US11130759, Cpd. No. 224::US11046691, Compound 224::(2R)-1-(7-chloro-2-oxo-1-phenylhydro- quinazolin-4-yl)pyrrolidine-2- carboxylic acid::US11084798, Cpd No 224	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507882&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608559	459092966							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071768	CNc1nc(=O)n(-c2ccccc2Br)c2cc(Cl)ccc12 |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.93,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-2.67,1.93,;-1.33,2.69,;,1.93,)|	InChI=1S/C15H11BrClN3O/c1-18-14-10-7-6-9(17)8-13(10)20(15(21)19-14)12-5-3-2-4-11(12)16/h2-8H,1H3,(H,18,19,21)	ZQJJGFPAOXBOAP-UHFFFAOYSA-N	507885	US11130759, Cpd. No. 368::US11046691, Compound 225::1-(2-bromophenyl)-7-chloro-4- (methylamino)quinazolin-2-one::US11084798, Cpd No 225	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507885&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608655	459092969							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071769	CNc1nc(=O)n(-c2ccccc2OC)c2cc(Cl)ccc12 |(2.85,4.98,;1.49,4.26,;1.44,2.72,;2.74,1.9,;2.69,.36,;4,-.45,;1.33,-.36,;1.28,-1.9,;2.59,-2.72,;2.54,-4.26,;1.18,-4.98,;-.13,-4.17,;-.08,-2.63,;-1.38,-1.81,;-2.74,-2.54,;.03,.45,;-1.33,-.27,;-2.64,.54,;-4,-.18,;-2.59,2.08,;-1.23,2.81,;.08,1.99,)|	InChI=1S/C16H14ClN3O2/c1-18-15-11-8-7-10(17)9-13(11)20(16(21)19-15)12-5-3-4-6-14(12)22-2/h3-9H,1-2H3,(H,18,19,21)	RHICTGAPZDERNC-UHFFFAOYSA-N	507888	US11130759, Cpd. No. 226::US11046691, Compound 226::7-chloro-1-(2-methoxyphenyl)-4- (methylamino)hydroquinazolin-2-one::US11084798, Cpd No 226	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507888&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608978	459092972							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071770	CN(C)c1nc(=O)n(-c2cccc(CCCc3ccccc3)c2)c2cc(Cl)ccc12	InChI=1S/C25H24ClN3O/c1-28(2)24-22-15-14-20(26)17-23(22)29(25(30)27-24)21-13-7-12-19(16-21)11-6-10-18-8-4-3-5-9-18/h3-5,7-9,12-17H,6,10-11H2,1-2H3	HBOBJFKBKFVMCQ-UHFFFAOYSA-N	507891	US11130759, Cpd. No. 227::US11046691, Compound 227::4-(dimethylamino)-7-chloro-1-[3-(3- phenylpropyl)phenyl]hydroquinazolin- 2-one::US11084798, Cpd No 227	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507891&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147747487	459092975							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071771	CN(C)c1nc(=O)n(-c2ccccc2)c2cc(ccc12)-c1cscn1	InChI=1S/C19H16N4OS/c1-22(2)18-15-9-8-13(16-11-25-12-20-16)10-17(15)23(19(24)21-18)14-6-4-3-5-7-14/h3-12H,1-2H3	YCJNEBRKQVFQJJ-UHFFFAOYSA-N	507894	US11130759, Cpd. No. 228::US11046691, Compound 228::4-(dimethylamino)-1-phenyl-7-(1,3- thiazol-4-yl)hydroquinazolin-2-one::US11084798, Cpd No 228	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507894&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149331385	459092978							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071772	Oc1ccc(cc1)-n1c2cc(Cl)ccc2c(=O)[nH]c1=O	InChI=1S/C14H9ClN2O3/c15-8-1-6-11-12(7-8)17(14(20)16-13(11)19)9-2-4-10(18)5-3-9/h1-7,18H,(H,16,19,20)	ISXIHJKMVWPORU-UHFFFAOYSA-N	507897	US11130759, Cpd. No. 229::US11046691, Compound 229::7-chloro-1-(4-hydroxyphenyl)-1,3- dihydroquinazoline-2,4-dione::US11084798, Cpd No 229	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507897&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370658	459092980							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071773	COC1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |w:2.1|	InChI=1S/C19H18ClN3O2/c1-25-15-9-10-22(12-15)18-16-8-7-13(20)11-17(16)23(19(24)21-18)14-5-3-2-4-6-14/h2-8,11,15H,9-10,12H2,1H3	QVDAMNRNSWSMMY-UHFFFAOYSA-N	507900	US11046691, Compound 230::7-chloro-4-(3-methoxypyrrolidin-1-yl)- 1-phenylquinazolin-2(1H)-one::US11084798, Cpd No 230	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507900&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608392	459092983							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071774	CN(C)C(=O)CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C18H17ClN4O2/c1-22(2)16(24)11-20-17-14-9-8-12(19)10-15(14)23(18(25)21-17)13-6-4-3-5-7-13/h3-10H,11H2,1-2H3,(H,20,21,25)	AXXXFHCIFHLKSF-UHFFFAOYSA-N	507903	US11130759, Cpd. No. 231::US11046691, Compound 231::2-[(7-chloro-2-oxo-1-phenyl-1,2- dihydroquinazolin-4-yl)amino]-N,N- dimethylacetamide::US11084798, Cpd No 231	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507903&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147032821	459092985							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071775	Clc1ccc2c(NCC3COC3)nc(=O)n(-c3ccccc3)c2c1	InChI=1S/C18H16ClN3O2/c19-13-6-7-15-16(8-13)22(14-4-2-1-3-5-14)18(23)21-17(15)20-9-12-10-24-11-12/h1-8,12H,9-11H2,(H,20,21,23)	KDRMFLJQIKVDQJ-UHFFFAOYSA-N	507906	US11130759, Cpd. No. 232::US11046691, Compound 232::7-chloro-4-[(oxetan-3-ylmethyl)amino]- 1-phenylhydroquinazolin-2-one::US11084798, Cpd No 232	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507906&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148177139	459092988							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071776	Cn1ccc(CNc2nc(=O)n(-c3ccccc3)c3cc(Cl)ccc23)n1	InChI=1S/C19H16ClN5O/c1-24-10-9-14(23-24)12-21-18-16-8-7-13(20)11-17(16)25(19(26)22-18)15-5-3-2-4-6-15/h2-11H,12H2,1H3,(H,21,22,26)	HNOCCYYLPNXFLE-UHFFFAOYSA-N	507909	US11130759, Cpd. No. 233::US11046691, Compound 233::7-chloro-4-1{[(1-methylpyrazol-3-yl)- methyl]amino}-1-phenylhydro- quinazolin-2-one::US11084798, Cpd No 233	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507909&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608519	459092991							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071777	CN(Cc1ccncc1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C21H17ClN4O/c1-25(14-15-9-11-23-12-10-15)20-18-8-7-16(22)13-19(18)26(21(27)24-20)17-5-3-2-4-6-17/h2-13H,14H2,1H3	NFNNGUKAZSZOAV-UHFFFAOYSA-N	507912	US11130759, Cpd. No. 234::US11046691, Compound 234::7-chloro-4-[methyl(pyridin-4- ylmethyl)-amino]-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 234	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507912&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608694	459092994							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071778	CN(Cc1cccnc1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C21H17ClN4O/c1-25(14-15-6-5-11-23-13-15)20-18-10-9-16(22)12-19(18)26(21(27)24-20)17-7-3-2-4-8-17/h2-13H,14H2,1H3	GJLRALAXEOULTI-UHFFFAOYSA-N	507915	US11130759, Cpd. No. 235::US11046691, Compound 235::7-chloro-4-[methyl(pyridin-3- ylmethyl)-amino]-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 235	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507915&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147650859	459092997							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071779	CN(Cc1ccccn1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C21H17ClN4O/c1-25(14-16-7-5-6-12-23-16)20-18-11-10-15(22)13-19(18)26(21(27)24-20)17-8-3-2-4-9-17/h2-13H,14H2,1H3	PJZJAUZIUMNFPX-UHFFFAOYSA-N	507918	US11130759, Cpd. No. 236::US11046691, Compound 236::7-chloro-4-[methyl(pyridin-2- ylmethyl)-amino]-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 236	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507918&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148918147	459093000							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071780	CN(CC(F)(F)F)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C17H13ClF3N3O/c1-23(10-17(19,20)21)15-13-8-7-11(18)9-14(13)24(16(25)22-15)12-5-3-2-4-6-12/h2-9H,10H2,1H3	GFNJUKIRCUMLSQ-UHFFFAOYSA-N	507921	US11130759, Cpd. No. 237::US11046691, Compound 237::7-chloro-4-[methyl(2,2,2- trifluoroethyl)-amino]-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 237	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507921&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608836	459093003							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071781	CC1(C)CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C20H20ClN3O/c1-20(2)10-11-23(13-20)18-16-9-8-14(21)12-17(16)24(19(25)22-18)15-6-4-3-5-7-15/h3-9,12H,10-11,13H2,1-2H3	LLSIRJMTVPLODT-UHFFFAOYSA-N	507924	US11130759, Cpd. No. 238::US11046691, Compound 238::4-(3,3-dimethylpyrrolidin-1-yl)-7- chloro-1-phenylhydroquinazolin-2-one::US11084798, Cpd No 238	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507924&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608623	459093006							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071782	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C18H16ClN3O2/c19-12-6-7-15-16(10-12)22(13-4-2-1-3-5-13)18(24)20-17(15)21-9-8-14(23)11-21/h1-7,10,14,23H,8-9,11H2	TXFRTHKEXGGQDR-UHFFFAOYSA-N	507927	US11130759, Cpd. No. 239::US11046691, Compound 239::4-((3R)-3-hydroxypyrrolidinyl)-7- chloro-1-phenylhydroquinazolin-2-one::US11084798, Cpd No 239	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507927&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151953898	459093009							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071783	NC(=O)[C@@H]1CCCN1c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C19H17ClN4O2/c20-12-8-9-14-16(11-12)24(13-5-2-1-3-6-13)19(26)22-18(14)23-10-4-7-15(23)17(21)25/h1-3,5-6,8-9,11,15H,4,7,10H2,(H2,21,25)	AQBDLQKUJKKHQN-UHFFFAOYSA-N	507930	US11130759, Cpd. No. 240::US11046691, Compound 240::(2S)-1-(7-chloro-2-oxo-1-phenylhydro- quinazolin-4-yl)pyrrolidine-2- carboxamide::US11084798, Cpd No 240	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507930&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608412	459093012							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071784	NC(=O)[C@H]1CCCN1c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |r|	InChI=1S/C19H17ClN4O2/c20-12-8-9-14-16(11-12)24(13-5-2-1-3-6-13)19(26)22-18(14)23-10-4-7-15(23)17(21)25/h1-3,5-6,8-9,11,15H,4,7,10H2,(H2,21,25)	AQBDLQKUJKKHQN-UHFFFAOYSA-N	507933	US11130759, Cpd. No. 241::US11046691, Compound 241::(2R)-1-(7-chloro-2-oxo-1-phenylhydro- quinazolin-4-yl)pyrrolidine-2- carboxamide::US11084798, Cpd No 241	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507933&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608817	459093015							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071785	Cc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12	InChI=1S/C15H11ClN2O/c1-10-13-8-7-11(16)9-14(13)18(15(19)17-10)12-5-3-2-4-6-12/h2-9H,1H3	GSPJTVUXVZEBDP-UHFFFAOYSA-N	507936	US11130759, Cpd. No. 242::US11046691, Compound 242::7-chloro-4-methyl-1-phenylhydro- quinazolin-2-one::US11084798, Cpd No 242	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507936&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608666	459093018							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071786	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)nnc12	InChI=1S/C13H10ClN5O/c1-15-12-11-9(7-10(14)17-18-11)19(13(20)16-12)8-5-3-2-4-6-8/h2-7H,1H3,(H,15,16,20)	ZHXIHDDONWJIQI-UHFFFAOYSA-N	507939	US11130759, Cpd. No. 243::US11046691, Compound 243::3-chloro-8-(methylamino)-5-phenyl-5- hydropyrimidino[5,4-c]pyridazin-6-one::US11084798, Cpd No 243	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507939&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608338	459093021							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071787	CN(C)c1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(,4.23,;1.33,3.46,;2.67,4.23,;1.33,1.92,;2.67,1.15,;2.67,-.39,;4,-1.16,;1.33,-1.16,;1.33,-2.7,;,-3.47,;,-5,;1.33,-5.78,;2.67,-5,;2.67,-3.47,;4,-2.69,;,-.39,;-1.33,-1.15,;-2.67,-.39,;-2.67,1.15,;-1.33,1.92,;,1.15,;-4,-1.16,;-5.33,-.39,;-4,-2.7,;-5.33,-1.93,)|	InChI=1S/C16H12ClF3N4O/c1-23(2)13-9-7-8-12(16(18,19)20)21-14(9)24(15(25)22-13)11-6-4-3-5-10(11)17/h3-8H,1-2H3	YDPSFAQJUWUEOL-UHFFFAOYSA-N	507904	US11130759, Cpd. No. 339::US11046691, Compound 339::4-(bis(methyl-d3)amino)-1-(2-chloro- phenyl)-7-(trifluoromethyl)-pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 244	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507904&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608851	459092986							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071788	FC(F)(F)c1ccc2c(NC3CC4(CCC4)C3)nc(=O)n(-c3ccccc3Cl)c2n1 |(-6.7,-.46,;-5.41,-1.3,;-5.49,-2.84,;-6.78,-2,;-4.04,-.6,;-3.96,.94,;-2.59,1.64,;-1.29,.8,;.08,1.5,;.16,3.04,;1.53,3.74,;2.99,3.26,;3.47,4.73,;4.94,4.25,;5.41,5.71,;3.95,6.19,;2.01,5.2,;1.37,.66,;1.29,-.88,;2.58,-1.72,;-.08,-1.58,;-.16,-3.11,;-1.54,-3.81,;-1.62,-5.35,;-.33,-6.19,;1.05,-5.49,;1.13,-3.95,;2.5,-3.25,;-1.38,-.74,;-2.75,-1.44,)|	InChI=1S/C21H18ClF3N4O/c22-14-4-1-2-5-15(14)29-18-13(6-7-16(27-18)21(23,24)25)17(28-19(29)30)26-12-10-20(11-12)8-3-9-20/h1-2,4-7,12H,3,8-11H2,(H,26,28,30)	ZOCXQOKUMZCATM-UHFFFAOYSA-N	507945	US11130759, Cpd. No. 245::US11046691, Compound 245::1-(2-chlorophenyl)-4-(spiro[3.3]heptan- 2-ylamino)-7-(trifluoromethyl)pyrido- [2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 245	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507945&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608725	459093027							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071789	FC(F)(F)c1ccc2c(NCC3CC3)nc(=O)n(-c3ccccc3Cl)c2n1 |(-5.33,-1.05,;-4,-1.82,;-4,-3.36,;-5.33,-2.59,;-2.67,-1.05,;-2.67,.49,;-1.33,1.26,;,.49,;1.33,1.26,;1.33,2.8,;2.67,3.57,;2.67,5.11,;3.44,6.44,;1.9,6.44,;2.67,.49,;2.67,-1.05,;4,-1.82,;1.33,-1.82,;1.33,-3.36,;,-4.13,;,-5.67,;1.33,-6.44,;2.67,-5.67,;2.67,-4.13,;4,-3.36,;,-1.05,;-1.33,-1.82,)|	InChI=1S/C18H14ClF3N4O/c19-12-3-1-2-4-13(12)26-16-11(7-8-14(24-16)18(20,21)22)15(25-17(26)27)23-9-10-5-6-10/h1-4,7-8,10H,5-6,9H2,(H,23,25,27)	MNFBOWOYIWBFEZ-UHFFFAOYSA-N	507948	US11130759, Cpd. No. 246::US11046691, Compound 246::1-(2-chlorophenyl)-4-((cyclopropyl- methypamino)-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 246	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507948&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148514727	459093030							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071790	OCCCNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(4.16,6.88,;4.11,5.34,;2.75,4.62,;2.69,3.08,;1.33,2.36,;1.28,.82,;2.59,,;2.53,-1.54,;3.84,-2.36,;1.17,-2.26,;1.12,-3.8,;-.24,-4.52,;-.3,-6.06,;1.01,-6.88,;2.37,-6.16,;2.42,-4.62,;3.78,-3.89,;-.13,-1.45,;-1.49,-2.17,;-2.8,-1.35,;-2.75,.19,;-1.39,.91,;-.08,.09,;-4.16,-2.08,;-5.47,-1.26,;-4.21,-3.61,;-5.52,-2.8,)|	InChI=1S/C17H14ClF3N4O2/c18-11-4-1-2-5-12(11)25-15-10(6-7-13(23-15)17(19,20)21)14(24-16(25)27)22-8-3-9-26/h1-2,4-7,26H,3,8-9H2,(H,22,24,27)	FFZNHHFOXIDNJF-UHFFFAOYSA-N	507951	US11130759, Cpd. No. 247::US11046691, Compound 247::1-(2-chlorophenyl)-4-[(3-hydroxy- propyl)amino]-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 247	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507951&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147493520	459093033							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071791	COCCCNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(4.67,7.31,;3.33,6.54,;3.33,5,;2,4.23,;2,2.69,;.67,1.92,;.67,.38,;2,-.39,;2,-1.93,;3.33,-2.7,;.67,-2.7,;.67,-4.24,;-.67,-5.01,;-.67,-6.55,;.67,-7.31,;2,-6.54,;2,-5.01,;3.33,-4.24,;-.67,-1.93,;-2,-2.7,;-3.33,-1.93,;-3.33,-.39,;-2,.38,;-.67,-.39,;-4.67,-2.7,;-6,-1.93,;-4.67,-4.23,;-6,-3.47,)|	InChI=1S/C18H16ClF3N4O2/c1-28-10-4-9-23-15-11-7-8-14(18(20,21)22)24-16(11)26(17(27)25-15)13-6-3-2-5-12(13)19/h2-3,5-8H,4,9-10H2,1H3,(H,23,25,27)	KCFYGFVRKYECBS-UHFFFAOYSA-N	507954	US11130759, Cpd. No. 248::US11046691, Compound 248::1-(2-chlorophenyl)-4-[(3-methoxy- propyl)amino]-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 248	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507954&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148169320	459093036							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071792	FC(F)CNc1nc(=O)n(-c2ccc3nccn3c2)c2cc(Cl)ccc12	InChI=1S/C17H12ClF2N5O/c18-10-1-3-12-13(7-10)25(17(26)23-16(12)22-8-14(19)20)11-2-4-15-21-5-6-24(15)9-11/h1-7,9,14H,8H2,(H,22,23,26)	OGJZMFIKSXHHQX-UHFFFAOYSA-N	507957	US11130759, Cpd. No. 249::US11046691, Compound 249::4-[(2,2-difluoroethyl)amino]-7-chloro- 1-(4-hydroimidazo[1,2-a]pyridin-6-yl)- hydroquinazolin-2-one::US11084798, Cpd No 249	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507957&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148760170	459093039							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071793	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccc3nccn3c2)c2cc(Cl)ccc12 |r|	InChI=1S/C19H16ClN5O2/c20-12-1-3-15-16(9-12)25(13-2-4-17-21-6-8-23(17)10-13)19(27)22-18(15)24-7-5-14(26)11-24/h1-4,6,8-10,14,26H,5,7,11H2	VZNVMRYUFUBFMY-UHFFFAOYSA-N	507960	US11130759, Cpd. No. 250::US11046691, Compound 250::4-((3R)-3-hydroxypyrrolidin-1-yl)-7- chloro-1-(4-hydroimidazo[1,2- a]pyridin-6-yl)-hydroquinazolin-2-one::US11084798, Cpd No 250	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507960&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153145983	459093042							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071794	CNc1nc(=O)n(-c2ccc3nccn3c2)c2cc(Cl)ccc12	InChI=1S/C16H12ClN5O/c1-18-15-12-4-2-10(17)8-13(12)22(16(23)20-15)11-3-5-14-19-6-7-21(14)9-11/h2-9H,1H3,(H,18,20,23)	GCTQYIHGLVQPIJ-UHFFFAOYSA-N	507963	US11130759, Cpd. No. 251::US11046691, Compound 251::7-chloro-1-(4-hydroimidazo[1,2-a]- pyridin-6-yl)-4-(methylamino)hydro- quinazolin-2-one::US11084798, Cpd No 251	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507963&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147615131	459093045							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071795	Nc1nc(=O)n(-c2ccc3nccn3c2)c2cc(Cl)ccc12	InChI=1S/C15H10ClN5O/c16-9-1-3-11-12(7-9)21(15(22)19-14(11)17)10-2-4-13-18-5-6-20(13)8-10/h1-8H,(H2,17,19,22)	WHRIHWLRXKASAQ-UHFFFAOYSA-N	507966	US11130759, Cpd. No. 252::US11046691, Compound 252::4-amino-7-chloro-1-(4-hydroimidazo- [1,2-a]pyridin-6-yl)hydroquinazolin-2- one::US11084798, Cpd No 252	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507966&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608773	459093048							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071796	Clc1ccc2c(c1)n(-c1nc3ccccc3s1)c(=O)[nH]c2=O	InChI=1S/C15H8ClN3O2S/c16-8-5-6-9-11(7-8)19(14(21)18-13(9)20)15-17-10-3-1-2-4-12(10)22-15/h1-7H,(H,18,20,21)	ZYIGIIBMQMCONJ-UHFFFAOYSA-N	507969	US11130759, Cpd. No. 253::US11046691, Compound 253::1-benzothiazol-2-yl-7-chloro-1,3- dihydroquinazoline-2,4-dione::US11084798, Cpd No 253	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507969&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370665	459093051							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071797	Clc1ccc2c(c1)n(-c1cccc3[nH]ncc13)c(=O)[nH]c2=O |(-4,-.28,;-2.7,.56,;-2.78,2.1,;-1.49,2.94,;-.12,2.24,;-.04,.7,;-1.33,-.14,;1.33,,;1.41,-1.54,;2.78,-2.24,;2.87,-3.77,;1.57,-4.61,;.2,-3.91,;-1.24,-4.47,;-2.21,-3.27,;-1.37,-1.98,;.12,-2.38,;2.62,.84,;4,.14,;2.54,2.38,;1.17,3.08,;1.09,4.61,)|	InChI=1S/C15H9ClN4O2/c16-8-4-5-9-13(6-8)20(15(22)18-14(9)21)12-3-1-2-11-10(12)7-17-19-11/h1-7H,(H,17,19)(H,18,21,22)	CNPAXOQKTRVQSI-UHFFFAOYSA-N	507972	US11130759, Cpd. No. 254::US11046691, Compound 254::1-(1H-indazol-4-yl)-7-chloro-1,3- dihydroquinazoline-2,4-dione::US11084798, Cpd No 254	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507972&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370667	459093054							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071798	CC1(O)CCN(C1)c1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |w:1.1,(-.54,5.47,;.95,5.08,;.55,6.56,;2.49,4.98,;2.87,3.49,;1.57,2.66,;.39,3.64,;1.49,1.13,;2.78,.29,;2.7,-1.25,;4,-2.09,;1.33,-1.95,;1.25,-3.49,;2.54,-4.33,;2.46,-5.86,;1.09,-6.56,;-.2,-5.73,;-.12,-4.19,;-1.41,-3.35,;.04,-1.11,;-1.33,-1.81,;-2.62,-.97,;-2.54,.57,;-1.17,1.27,;.12,.43,;-4,-1.67,;-5.29,-.83,;-4.08,-3.21,;-5.37,-2.37,)|	InChI=1S/C19H16ClF3N4O2/c1-18(29)8-9-26(10-18)15-11-6-7-14(19(21,22)23)24-16(11)27(17(28)25-15)13-5-3-2-4-12(13)20/h2-7,29H,8-10H2,1H3	XUWCMWXRZYJTHC-UHFFFAOYSA-N	507975	US11130759, Cpd. No. 255::US11046691, Compound 255::1-(2-chlorophenyl)-4-(3-hydroxy-3- methylpyrrolidin-1-yl)-7-(trifluoro- methyphydropyridino-[2,3-d]pyrimidin- 2-one::US11084798, Cpd No 255	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507975&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609016	459093057							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071799	FC(F)(F)c1ccc2c(Nc3ccccn3)nc(=O)n(-c3ccccc3Cl)c2n1 |(-5.89,-1.19,;-4.52,-1.89,;-4.44,-3.42,;-5.81,-2.73,;-3.23,-1.05,;-3.31,.49,;-2.02,1.33,;-.65,.63,;.65,1.47,;.57,3.01,;1.86,3.84,;1.78,5.38,;3.07,6.22,;4.44,5.52,;4.52,3.98,;3.23,3.15,;2.02,.77,;2.1,-.77,;3.47,-1.47,;.81,-1.61,;.89,-3.15,;2.26,-3.84,;2.34,-5.38,;1.05,-6.22,;-.32,-5.52,;-.4,-3.98,;-1.78,-3.29,;-.57,-.91,;-1.86,-1.75,)|	InChI=1S/C19H11ClF3N5O/c20-12-5-1-2-6-13(12)28-17-11(8-9-14(25-17)19(21,22)23)16(27-18(28)29)26-15-7-3-4-10-24-15/h1-10H,(H,24,26,27,29)	IXXNOELRQXLFFG-UHFFFAOYSA-N	507978	US11130759, Cpd. No. 256::US11046691, Compound 256::1-(2-chlorophenyl)-4-(2-pyridylamino)- 7-(trifluoromethyl)pyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 256	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507978&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608405	459093060							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071800	Cn1ccc(CNc2nc(=O)n(-c3ccccc3Cl)c3nc(ccc23)C(F)(F)F)n1 |(4.39,7.34,;3.05,6.57,;1.51,6.57,;1.04,5.11,;2.28,4.21,;2.28,2.67,;.95,1.9,;.95,.36,;2.28,-.41,;2.28,-1.95,;3.62,-2.72,;.95,-2.72,;.95,-4.26,;2.28,-5.03,;2.28,-6.57,;.95,-7.34,;-.38,-6.57,;-.38,-5.03,;-1.72,-4.26,;-.38,-1.95,;-1.72,-2.72,;-3.05,-1.95,;-3.05,-.41,;-1.72,.36,;-.38,-.41,;-4.39,-2.72,;-5.72,-1.95,;-4.39,-4.26,;-5.72,-3.49,;3.53,5.11,)|	InChI=1S/C19H14ClF3N6O/c1-28-9-8-11(27-28)10-24-16-12-6-7-15(19(21,22)23)25-17(12)29(18(30)26-16)14-5-3-2-4-13(14)20/h2-9H,10H2,1H3,(H,24,26,30)	SKWZVJLWVLLGLF-UHFFFAOYSA-N	507981	US11130759, Cpd. No. 257::US11046691, Compound 257::1-(2-chlorophenyl)-4-{[(1-methyl- pyrazol-3-yl)methyl]amino }-7- (trifluoro-methyl)-pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 257	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507981&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608471	459093063							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071801	CC(C)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(2.67,5.78,;2.67,4.23,;4,3.47,;1.33,3.47,;1.33,1.93,;2.67,1.15,;2.67,-.38,;4,-1.15,;1.33,-1.15,;1.33,-2.69,;2.67,-3.47,;2.67,-5,;1.33,-5.78,;,-5,;,-3.47,;-1.33,-2.69,;,-.38,;-1.33,-1.15,;-2.67,-.38,;-2.67,1.15,;-1.33,1.93,;,1.15,;-4,-1.15,;-5.33,-.38,;-4,-2.69,;-5.33,-1.92,)|	InChI=1S/C17H14ClF3N4O/c1-9(2)22-14-10-7-8-13(17(19,20)21)23-15(10)25(16(26)24-14)12-6-4-3-5-11(12)18/h3-9H,1-2H3,(H,22,24,26)	WTWPADOKHCZGPJ-UHFFFAOYSA-N	507984	US11130759, Cpd. No. 258::US11046691, Compound 258::1-(2-chlorophenyl)-4-[(methylethyl)- amino]-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 258	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507984&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608484	459093066							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071802	CC(C)(C)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(2.67,5.78,;2.67,4.23,;4,3.47,;4,5,;1.33,3.47,;1.33,1.93,;2.67,1.15,;2.67,-.38,;4,-1.15,;1.33,-1.15,;1.33,-2.69,;2.67,-3.47,;2.67,-5,;1.33,-5.78,;,-5,;,-3.47,;-1.33,-2.69,;,-.38,;-1.33,-1.15,;-2.67,-.38,;-2.67,1.15,;-1.33,1.93,;,1.15,;-4,-1.15,;-5.33,-.38,;-4,-2.69,;-5.33,-1.92,)|	InChI=1S/C18H16ClF3N4O/c1-17(2,3)25-14-10-8-9-13(18(20,21)22)23-15(10)26(16(27)24-14)12-7-5-4-6-11(12)19/h4-9H,1-3H3,(H,24,25,27)	LMNZMPCHENZRAS-UHFFFAOYSA-N	507987	US11130759, Cpd. No. 259::US11046691, Compound 259::4-[(tert-butyl)amino]-1-(2-chloro- phenyl)-7-(trifluoromethyl)pyrido-[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 259	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507987&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608581	459093069							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071803	CNc1nc(=O)n(-c2ncccc2C)c2nc(ccc12)C(F)(F)F |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.93,;,.38,;-1.33,-.38,;-2.67,.38,;-2.67,1.93,;-1.33,2.69,;,1.93,;-4,-.38,;-5.33,.39,;-4,-1.92,;-5.33,-1.15,)|	InChI=1S/C15H12F3N5O/c1-8-4-3-7-20-12(8)23-13-9(11(19-2)22-14(23)24)5-6-10(21-13)15(16,17)18/h3-7H,1-2H3,(H,19,22,24)	FZPNIWGTEMTMFA-UHFFFAOYSA-N	507990	US11130759, Cpd. No. 260::US11046691, Compound 260::1-(3-methyl(2-pyridyl))-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 260	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507990	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507990&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150251289	459093072							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071804	CNc1nc(=O)n(-c2ncccc2Cl)c2nc(ccc12)C(F)(F)F |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.93,;,.38,;-1.33,-.38,;-2.67,.38,;-2.67,1.93,;-1.33,2.69,;,1.93,;-4,-.38,;-5.33,.39,;-4,-1.92,;-5.33,-1.15,)|	InChI=1S/C14H9ClF3N5O/c1-19-10-7-4-5-9(14(16,17)18)21-11(7)23(13(24)22-10)12-8(15)3-2-6-20-12/h2-6H,1H3,(H,19,22,24)	HMYBELPQGUBZHT-UHFFFAOYSA-N	507992	US11130759, Cpd. No. 261::US11046691, Compound 261::1-(3-chloro(2-pyridyl))-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 261	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507992&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608212	459093074							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071805	CNc1nc(=O)n(Cc2c[nH]cn2)c2nc(Cl)ccc12	InChI=1S/C12H11ClN6O/c1-14-10-8-2-3-9(13)17-11(8)19(12(20)18-10)5-7-4-15-6-16-7/h2-4,6H,5H2,1H3,(H,15,16)(H,14,18,20)	MMKADDJWGYMTRZ-UHFFFAOYSA-N	511928	US11084798, Cpd No 262::7-chloro-1-(imidazol-4-ylmethyl)-4- (methylamino)hydroquinazolin-2-one	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=511928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=511928&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			159608660	459629179							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071806	Cc1ncccc1-n1c2nc(ccc2c(N)nc1=O)C(F)(F)F |(4,-1.54,;2.67,-2.31,;2.67,-3.85,;1.33,-4.62,;,-3.85,;,-2.31,;1.33,-1.54,;1.33,,;,.77,;-1.33,,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;1.33,3.08,;1.33,4.62,;2.67,2.31,;2.67,.77,;4,,;-4,,;-5.33,.77,;-4,-1.54,;-5.33,-.77,)|	InChI=1S/C14H10F3N5O/c1-7-9(3-2-6-19-7)22-12-8(11(18)21-13(22)23)4-5-10(20-12)14(15,16)17/h2-6H,1H3,(H2,18,21,23)	SQHYLYPWQLEYST-UHFFFAOYSA-N	507998	US11130759, Cpd. No. 263::US11046691, Compound 263::4-amino-1-(2-methyl(3-pyridyl))-7- (trifluoromethyl pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 263	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507998&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608713	459093078							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071807	CS(=O)(=O)CCNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(4.67,4.62,;3.33,5.39,;3.33,6.93,;2,6.16,;2,4.62,;2,3.08,;.67,2.31,;.67,.77,;2,,;2,-1.54,;3.33,-2.31,;.67,-2.31,;.67,-3.85,;-.67,-4.62,;-.67,-6.16,;.67,-6.93,;2,-6.16,;2,-4.62,;3.33,-3.85,;-.67,-1.54,;-2,-2.31,;-3.33,-1.54,;-3.33,,;-2,.77,;-.67,,;-4.67,-2.31,;-6,-1.54,;-4.67,-3.85,;-6,-3.08,)|	InChI=1S/C17H14ClF3N4O3S/c1-29(27,28)9-8-22-14-10-6-7-13(17(19,20)21)23-15(10)25(16(26)24-14)12-5-3-2-4-11(12)18/h2-7H,8-9H2,1H3,(H,22,24,26)	GFZZVVURPPLYKA-UHFFFAOYSA-N	508001	US11130759, Cpd. No. 264::US11046691, Compound 264::1-(2-chlorophenyl)-4-{[2-(methyl- sulfonyl)ethyl]amino}-7-(trifluoro- methyl)pyrido [2,3-d]pyrimidin-2 (1H)- one::US11084798, Cpd No 264	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508001&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156541975	459093081							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071808	OCC1(CNc2nc(=O)n(-c3ccccc3Cl)c3nc(ccc23)C(F)(F)F)CC1 |(5.33,4.23,;4,5,;2.67,4.23,;1.33,5,;,4.23,;,2.69,;1.33,1.93,;1.33,.38,;2.67,-.38,;,-.38,;,-1.93,;1.33,-2.69,;1.33,-4.23,;,-5,;-1.33,-4.23,;-1.33,-2.69,;-2.67,-1.92,;-1.33,.38,;-2.67,-.38,;-4,.38,;-4,1.93,;-2.67,2.69,;-1.33,1.93,;-5.33,-.38,;-6.67,.39,;-5.33,-1.92,;-6.67,-1.15,;1.9,2.9,;3.44,2.9,)|	InChI=1S/C19H16ClF3N4O2/c20-12-3-1-2-4-13(12)27-16-11(5-6-14(25-16)19(21,22)23)15(26-17(27)29)24-9-18(10-28)7-8-18/h1-6,28H,7-10H2,(H,24,26,29)	JJTOUZQELWGZPS-UHFFFAOYSA-N	508004	US11130759, Cpd. No. 265::US11046691, Compound 265::1-(2-chlorophenyl)-4-(((1-(hydroxy- methyl)cyclopropyl)methypamino)-7- (trifluoromethyl)-pyrid [2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 265	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508004&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156541994	459093084							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071809	CN(C)CCCNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(2,7.32,;3.33,6.55,;4.67,7.31,;3.33,5.01,;2,4.23,;2,2.69,;.67,1.92,;.67,.38,;2,-.39,;2,-1.93,;3.33,-2.69,;.67,-2.7,;.67,-4.23,;-.67,-5.01,;-.67,-6.55,;.67,-7.32,;2,-6.55,;2,-5.01,;3.33,-4.23,;-.67,-1.93,;-2,-2.7,;-3.33,-1.92,;-3.33,-.38,;-2,.38,;-.67,-.38,;-4.67,-2.7,;-6,-1.93,;-4.67,-4.24,;-6,-3.47,)|	InChI=1S/C19H19ClF3N5O/c1-27(2)11-5-10-24-16-12-8-9-15(19(21,22)23)25-17(12)28(18(29)26-16)14-7-4-3-6-13(14)20/h3-4,6-9H,5,10-11H2,1-2H3,(H,24,26,29)	KZCSFWOCKIFLTD-UHFFFAOYSA-N	508007	US11130759, Cpd. No. 266::US11046691, Compound 266::4-{[3-(dimethylamino)propyl]amino}- 1-(2-ch1orophenyl)-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 266	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508007&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514111	459093087							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071810	CN(C)CCNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(2.82,7.02,;2.95,5.49,;4.35,4.83,;1.69,4.6,;1.83,3.07,;.56,2.18,;.7,.65,;2.09,,;2.23,-1.53,;3.62,-2.18,;.97,-2.42,;1.1,-3.95,;-.16,-4.83,;-.03,-6.37,;1.37,-7.02,;2.63,-6.14,;2.5,-4.6,;3.76,-3.72,;-.43,-1.77,;-1.69,-2.65,;-3.09,-2,;-3.22,-.46,;-1.96,.42,;-.56,-.23,;-4.35,-2.88,;-5.74,-2.23,;-4.21,-4.42,;-5.61,-3.77,)|	InChI=1S/C18H17ClF3N5O/c1-26(2)10-9-23-15-11-7-8-14(18(20,21)22)24-16(11)27(17(28)25-15)13-6-4-3-5-12(13)19/h3-8H,9-10H2,1-2H3,(H,23,25,28)	IVPQDMGOSGSLME-UHFFFAOYSA-N	508010	US11130759, Cpd. No. 267::US11046691, Compound 267::4-{[2-(dimethylamino)ethyl]amino}-1- (2-chlorophenyl)-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 267	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508010&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608503	459093090							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071811	C[C@@]1(O)C[C@@H](C1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:4.6,1.1,wD:1.0,(-4.55,-2.58,;-4.94,-1.09,;-6.28,-1.86,;-3.46,-1.49,;-3.06,,;-4.55,.4,;-1.72,.77,;-.39,,;-.39,-1.54,;.94,-2.31,;.94,-3.85,;2.28,-1.54,;3.61,-2.31,;4.94,-1.54,;6.28,-2.31,;6.28,-3.85,;4.94,-4.62,;3.61,-3.85,;2.28,-4.62,;2.28,,;3.61,.77,;3.61,2.31,;2.28,3.08,;.94,2.31,;.94,.77,;4.94,3.08,;4.94,4.62,;6.28,3.85,;6.28,2.31,)|	InChI=1S/C19H16ClF3N4O2/c1-18(29)8-10(9-18)24-15-11-6-7-14(19(21,22)23)25-16(11)27(17(28)26-15)13-5-3-2-4-12(13)20/h2-7,10,29H,8-9H2,1H3,(H,24,26,28)	HORDOUGRQWGGKG-UHFFFAOYSA-N	508013	US11130759, Cpd. No. 268::US11046691, Compound 268::1-(2-chlorophenyl)-4-(((1s,3s)-3- hydroxy-3-methylcyclobutyl)amino)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 268	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508013&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608547	459093093							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071812	C[C@]1(C[C@H](O)C1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.0,wD:1.6,3.3,(-2.66,1.49,;-3.06,,;-3.46,-1.49,;-4.94,-1.09,;-6.28,-1.86,;-4.55,.4,;-1.72,.77,;-.39,,;-.39,-1.54,;.94,-2.31,;.94,-3.85,;2.28,-1.54,;3.61,-2.31,;4.94,-1.54,;6.28,-2.31,;6.28,-3.85,;4.94,-4.62,;3.61,-3.85,;2.28,-4.62,;2.28,,;3.61,.77,;3.61,2.31,;2.28,3.08,;.94,2.31,;.94,.77,;4.94,3.08,;4.94,4.62,;6.28,3.85,;6.28,2.31,)|	InChI=1S/C19H16ClF3N4O2/c1-18(8-10(28)9-18)26-15-11-6-7-14(19(21,22)23)24-16(11)27(17(29)25-15)13-5-3-2-4-12(13)20/h2-7,10,28H,8-9H2,1H3,(H,25,26,29)	QCTQXLWBIHPUJN-UHFFFAOYSA-N	508016	US11130759, Cpd. No. 269::US11046691, Compound 269::1-(2-chlorophenyl)-4-(((1s,3s)-3- hydroxy-1-methylcyclobutyl)amino)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 269	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508016&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608645	459093096							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071813	CO[C@@H]1C[C@@H](C1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:4.6,2.1,(4.94,6.7,;4.94,5.16,;3.61,4.39,;2.12,4.79,;1.72,3.31,;3.21,2.91,;.39,2.54,;.39,1,;1.72,.23,;1.72,-1.31,;3.06,-2.08,;.39,-2.08,;.39,-3.62,;-.94,-4.39,;-.94,-5.93,;.39,-6.7,;1.72,-5.93,;1.72,-4.39,;3.06,-3.62,;-.94,-1.31,;-2.28,-2.08,;-3.61,-1.31,;-3.61,.23,;-2.28,1,;-.94,.23,;-4.94,-2.08,;-6.28,-1.31,;-4.94,-3.62,;-6.28,-2.85,)|	InChI=1S/C19H16ClF3N4O2/c1-29-11-8-10(9-11)24-16-12-6-7-15(19(21,22)23)25-17(12)27(18(28)26-16)14-5-3-2-4-13(14)20/h2-7,10-11H,8-9H2,1H3,(H,24,26,28)	NJFQRSUSEQSSCD-UHFFFAOYSA-N	508019	US11130759, Cpd. No. 270::US11046691, Compound 270::1-(2-chlorophenyl)-4-(((1s,3s)-3- methoxycyclobutyl)amino)-7-(trifluoro- methyl)pyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 270	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508019&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608247	459093099							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071814	FC(F)(F)c1ccc2c(NCC3CCO3)nc(=O)n(-c3ccccc3Cl)c2n1 |w:10.10,(-5.33,-1.47,;-4,-2.24,;-4,-3.78,;-5.33,-3.01,;-2.67,-1.47,;-2.67,.07,;-1.33,.84,;,.07,;1.33,.84,;1.33,2.38,;2.67,3.15,;2.67,4.69,;3.76,5.77,;2.67,6.86,;1.58,5.77,;2.67,.07,;2.67,-1.47,;4,-2.24,;1.33,-2.24,;1.33,-3.78,;,-4.55,;,-6.09,;1.33,-6.86,;2.67,-6.09,;2.67,-4.55,;4,-3.78,;,-1.47,;-1.33,-2.24,)|	InChI=1S/C18H14ClF3N4O2/c19-12-3-1-2-4-13(12)26-16-11(5-6-14(24-16)18(20,21)22)15(25-17(26)27)23-9-10-7-8-28-10/h1-6,10H,7-9H2,(H,23,25,27)	AKOWBGJTPJSDHN-UHFFFAOYSA-N	508022	US11046691, Compound 271::1-(2-chlorophenyl)-4-[(oxetan-2- ylmethyl)amino]-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 271	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508022&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514063	459093102							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071815	CNc1nc(=O)n(-c2ccccc2C)c2nc(ccc12)C(F)(F)F |(2.67,4.23,;1.33,3.47,;1.33,1.93,;2.67,1.15,;2.67,-.38,;4,-1.15,;1.33,-1.15,;1.33,-2.69,;,-3.47,;,-5,;1.33,-5.78,;2.67,-5,;2.67,-3.47,;4,-2.69,;,-.38,;-1.33,-1.15,;-2.67,-.38,;-2.67,1.16,;-1.33,1.93,;,1.16,;-4,-1.15,;-5.33,-.38,;-4,-2.69,;-5.33,-1.92,)|	InChI=1S/C16H13F3N4O/c1-9-5-3-4-6-11(9)23-14-10(13(20-2)22-15(23)24)7-8-12(21-14)16(17,18)19/h3-8H,1-2H3,(H,20,22,24)	FXODBRHLYUSETA-UHFFFAOYSA-N	508025	US11130759, Cpd. No. 272::US11046691, Compound 272::4-((methyl-d3)amino)-1-(2-methyl- phenyl)-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 272	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508025&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608569	459093105							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071816	C[C@@H](CO)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.0,(-3.33,-1.54,;-3.33,,;-4.67,.77,;-6,,;-2,.77,;-.67,,;-.67,-1.54,;.67,-2.31,;.67,-3.85,;2,-1.54,;3.33,-2.31,;4.67,-1.54,;6,-2.31,;6,-3.85,;4.67,-4.62,;3.33,-3.85,;2,-4.62,;2,,;3.33,.77,;3.33,2.31,;2,3.08,;.67,2.31,;.67,.77,;4.67,3.08,;4.67,4.62,;6,3.85,;6,2.31,)|	InChI=1S/C17H14ClF3N4O2/c1-9(8-26)22-14-10-6-7-13(17(19,20)21)23-15(10)25(16(27)24-14)12-5-3-2-4-11(12)18/h2-7,9,26H,8H2,1H3,(H,22,24,27)	NNBLPRBYZBYTJP-UHFFFAOYSA-N	508028	US11130759, Cpd. No. 292::US11046691, Compound 273::4-[((1S)-2-hydroxy-isopropyl)amino]- (1Ra)-(2-chlorophenyl)-7-(trifluoro- methyl)-pyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 292	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508028&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608438	459093108							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071817	C[C@@H](CO)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.0,(-3.33,-1.54,;-3.33,,;-4.67,.77,;-6,,;-2,.77,;-.67,,;-.67,-1.54,;.67,-2.31,;.67,-3.85,;2,-1.54,;3.33,-2.31,;4.67,-1.54,;6,-2.31,;6,-3.85,;4.67,-4.62,;3.33,-3.85,;2,-4.62,;2,,;3.33,.77,;3.33,2.31,;2,3.08,;.67,2.31,;.67,.77,;4.67,3.08,;4.67,4.62,;6,3.85,;6,2.31,)|	InChI=1S/C17H14ClF3N4O2/c1-9(8-26)22-14-10-6-7-13(17(19,20)21)23-15(10)25(16(27)24-14)12-5-3-2-4-11(12)18/h2-7,9,26H,8H2,1H3,(H,22,24,27)	NNBLPRBYZBYTJP-UHFFFAOYSA-N	508028	US11130759, Cpd. No. 292::US11046691, Compound 273::4-[((1S)-2-hydroxy-isopropyl)amino]- (1Ra)-(2-chlorophenyl)-7-(trifluoro- methyl)-pyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 292	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508028&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608438	459093108							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071818	FC(F)(F)c1ccc2c(NC3COC3)nc(=O)n(-c3ccccc3Cl)c2n1 |(-5.61,-.36,;-4.28,-1.13,;-4.28,-2.67,;-5.61,-1.9,;-2.94,-.36,;-2.94,1.18,;-1.61,1.95,;-.28,1.18,;1.06,1.95,;1.06,3.49,;2.39,4.26,;3.88,3.86,;4.28,5.35,;2.79,5.75,;2.39,1.18,;2.39,-.36,;3.72,-1.13,;1.06,-1.13,;1.06,-2.67,;-.28,-3.44,;-.28,-4.98,;1.06,-5.75,;2.39,-4.98,;2.39,-3.44,;3.72,-2.67,;-.28,-.36,;-1.61,-1.13,)|	InChI=1S/C17H12ClF3N4O2/c18-11-3-1-2-4-12(11)25-15-10(5-6-13(23-15)17(19,20)21)14(24-16(25)26)22-9-7-27-8-9/h1-6,9H,7-8H2,(H,22,24,26)	BEHSMTXXBSBQLT-UHFFFAOYSA-N	508032	US11130759, Cpd. No. 274::US11046691, Compound 274::1-(2-chlorophenyl)-4-(oxetan-3-yl- amino)-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 274	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508032&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608273	459093112							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071819	O[C@@]1(C[C@@H](C1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F)C(F)(F)F |r,wU:1.31,wD:3.5,1.0,(4.3,5.93,;2.96,5.16,;2.57,3.68,;1.08,4.08,;1.48,5.56,;-.26,3.31,;-.26,1.77,;1.08,1,;1.08,-.54,;2.41,-1.31,;-.26,-1.31,;-.26,-2.85,;-1.59,-3.62,;-1.59,-5.16,;-.26,-5.93,;1.08,-5.16,;1.08,-3.62,;2.41,-2.85,;-1.59,-.54,;-2.92,-1.31,;-4.26,-.54,;-4.26,1,;-2.92,1.77,;-1.59,1,;-5.59,-1.31,;-6.92,-.54,;-5.59,-2.85,;-6.92,-2.08,;4.26,4.48,;4.26,2.94,;5.59,3.71,;5.59,5.25,)|	InChI=1S/C19H13ClF6N4O2/c20-11-3-1-2-4-12(11)30-15-10(5-6-13(28-15)18(21,22)23)14(29-16(30)31)27-9-7-17(32,8-9)19(24,25)26/h1-6,9,32H,7-8H2,(H,27,29,31)	QZDSJFRFBJGPAM-UHFFFAOYSA-N	508035	US11130759, Cpd. No. 275::US11046691, Compound 275::4-{[(cis)-3-hydroxy-3-(trifluoromethyl)- cyclobutyl]amino}-1-(2-chlorophenyl)- 7-(trifluoromethyl)pyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 275	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508035&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608287	459093115							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071820	CC1(C)[C@H](O)C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:6.7,3.3,(-5.32,1.73,;-4.55,.4,;-6.09,.2,;-4.94,-1.09,;-6.28,-1.86,;-3.46,-1.49,;-3.06,,;-1.72,.77,;-.39,,;-.39,-1.54,;.94,-2.31,;.94,-3.85,;2.28,-1.54,;3.61,-2.31,;4.94,-1.54,;6.28,-2.31,;6.28,-3.85,;4.94,-4.62,;3.61,-3.85,;2.28,-4.62,;2.28,,;3.61,.77,;3.61,2.31,;2.28,3.08,;.94,2.31,;.94,.77,;4.94,3.08,;4.94,4.62,;6.28,3.85,;6.28,2.31,)|	InChI=1S/C20H18ClF3N4O2/c1-19(2)14(9-15(19)29)25-16-10-7-8-13(20(22,23)24)26-17(10)28(18(30)27-16)12-6-4-3-5-11(12)21/h3-8,14-15,29H,9H2,1-2H3,(H,25,27,30)	RONDHTCYNVCPKX-UHFFFAOYSA-N	508038	US11130759, Cpd. No. 276::US11046691, Compound 276::4-[((cis)-3-hydroxy-2,2-dimethylcyclo- butyl)amino]-1-(2-chlorophenyl)-7- (trifluoromethyl)-pyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 276	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508038&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608758	459093118							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071821	FC(F)(F)c1ccc2c(NC3(CCC3)C#N)nc(=O)n(-c3ccccc3Cl)c2n1 |(-5.61,-.75,;-4.28,-1.52,;-4.28,-3.06,;-5.61,-2.29,;-2.94,-.75,;-2.94,.79,;-1.61,1.56,;-.28,.79,;1.06,1.56,;1.06,3.1,;2.39,3.87,;3.88,3.48,;4.28,4.96,;2.79,5.36,;1.3,4.96,;.29,6.14,;2.39,.79,;2.39,-.75,;3.72,-1.52,;1.06,-1.52,;1.06,-3.06,;-.28,-3.83,;-.28,-5.37,;1.06,-6.14,;2.39,-5.37,;2.39,-3.83,;3.72,-3.06,;-.28,-.75,;-1.61,-1.52,)|	InChI=1S/C19H13ClF3N5O/c20-12-4-1-2-5-13(12)28-16-11(6-7-14(25-16)19(21,22)23)15(26-17(28)29)27-18(10-24)8-3-9-18/h1-2,4-7H,3,8-9H2,(H,26,27,29)	SODOTTAULBMGCL-UHFFFAOYSA-N	508041	US11130759, Cpd. No. 277::US11046691, Compound 277::1-((1-(2-chlorophenyl)-2-oxo-7- (trifluoromethyl)-1,2- dihydropyrido[2,3-d]pyrimidin-4- yl)amino)cyclobutane-1-carbonitrile::US11084798, Cpd No 277	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508041&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608875	459093121							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071822	FC(F)(F)c1ccc2c(NCCC#N)nc(=O)n(-c3ccccc3Cl)c2n1 |(-5.68,-1.91,;-4.28,-2.56,;-4.15,-4.09,;-5.54,-3.44,;-3.02,-1.67,;-3.15,-.14,;-1.89,.74,;-.5,.09,;.76,.98,;.63,2.51,;1.89,3.39,;1.76,4.93,;3.02,5.81,;4.28,6.69,;2.16,.33,;2.29,-1.21,;3.69,-1.86,;1.03,-2.09,;1.17,-3.63,;-.09,-4.51,;.04,-6.04,;1.44,-6.69,;2.7,-5.81,;2.56,-4.28,;3.82,-3.39,;-.36,-1.44,;-1.62,-2.32,)|	InChI=1S/C17H11ClF3N5O/c18-11-4-1-2-5-12(11)26-15-10(6-7-13(24-15)17(19,20)21)14(25-16(26)27)23-9-3-8-22/h1-2,4-7H,3,9H2,(H,23,25,27)	LGUWTXZVCRYUGH-UHFFFAOYSA-N	508044	US11130759, Cpd. No. 278::US11046691, Compound 278::3-((1-(2-chlorophenyl)-2-oxo-7- (trifluoro-methyl)-1,2-dihydropyrido- [2,3-d]pyrimidin-4-yl)amino)- propanenitrile::US11084798, Cpd No 278	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508044&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608857	459093124							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071823	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccc3[nH]ncc3c2)c2cc(Cl)ccc12 |r|	InChI=1S/C19H16ClN5O2/c20-12-1-3-15-17(8-12)25(13-2-4-16-11(7-13)9-21-23-16)19(27)22-18(15)24-6-5-14(26)10-24/h1-4,7-9,14,26H,5-6,10H2,(H,21,23)	LLBCXPATBKNSMX-UHFFFAOYSA-N	508047	US11130759, Cpd. No. 279::US11046691, Compound 279::(R)-7-chloro-4-(3-hydroxypyrrolidin-1- yl)-1-(1H-indazol-5-yl)quinazolin- 2(1H)-one::US11084798, Cpd No 279	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508047&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933487	459093127							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071824	CN(C)c1nc(=O)n(-c2ccc3[nH]ncc3c2)c2cc(Cl)ccc12	InChI=1S/C17H14ClN5O/c1-22(2)16-13-5-3-11(18)8-15(13)23(17(24)20-16)12-4-6-14-10(7-12)9-19-21-14/h3-9H,1-2H3,(H,19,21)	QQWPNKCMPVSRST-UHFFFAOYSA-N	508050	US11130759, Cpd. No. 280::US11046691, Compound 280::7-chloro-4-(dimethylamino)-1-(1H- indazol-5-yl)quinazolin-2(1H)-one::US11084798, Cpd No 280	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508050&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608994	459093130							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071825	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccc3[nH]cnc3c2)c2cc(Cl)ccc12 |r|	InChI=1S/C19H16ClN5O2/c20-11-1-3-14-17(7-11)25(12-2-4-15-16(8-12)22-10-21-15)19(27)23-18(14)24-6-5-13(26)9-24/h1-4,7-8,10,13,26H,5-6,9H2,(H,21,22)	UUNRCBCLCGGASA-UHFFFAOYSA-N	508053	US11130759, Cpd. No. 281::US11046691, Compound 281::(R)-7-chloro-4-(3-hydroxypyrrolidin-1- yl)-1-(1H-benzimidazol-5- yl)quinazolin-2(1H)-one::US11084798, Cpd No 281	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508053&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608984	459093133							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071826	Cc1ncccc1-n1c2cc(ccc2c(NCC(F)F)nc1=O)C(F)(F)F |(-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;2.67,-5.39,;2.67,-3.85,;1.33,-3.08,;1.33,-1.54,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;,.77,;1.33,1.54,;1.33,3.08,;2.67,3.85,;2.67,5.39,;4,6.16,;1.33,6.16,;2.67,.77,;2.67,-.77,;4,-1.54,;-4,-1.54,;-5.33,-.77,;-4,-3.08,;-5.33,-2.31,)|	InChI=1S/C17H13F5N4O/c1-9-12(3-2-6-23-9)26-13-7-10(17(20,21)22)4-5-11(13)15(25-16(26)27)24-8-14(18)19/h2-7,14H,8H2,1H3,(H,24,25,27)	LIKUIQLWFDTKFN-UHFFFAOYSA-N	508056	US11130759, Cpd. No. 282::US11046691, Compound 282::4-((2,2-difluoroethyl)amino)-1-(2- methylpyridin-3-yl)-7- (trifluoromethyl)-quinazolin-2(1H)-one::US11084798, Cpd No 282	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508056&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608695	459093136							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071827	Cc1ncccc1-n1c2cc(ccc2c(nc1=O)N1CC[C@@H](O)C1)C(F)(F)F |r,wU:21.24,(3.89,.1,;3.89,-1.44,;5.22,-2.21,;5.22,-3.75,;3.89,-4.52,;2.55,-3.75,;2.55,-2.21,;1.22,-1.44,;1.22,.1,;2.55,.87,;2.55,2.41,;1.22,3.18,;-.11,2.41,;-.11,.87,;-1.45,.1,;-1.45,-1.44,;-.11,-2.21,;-.11,-3.75,;-2.78,.87,;-4.19,.25,;-5.22,1.39,;-4.45,2.72,;-5.08,4.13,;-2.94,2.4,;3.89,3.18,;5.22,3.95,;3.12,4.52,;4.66,1.85,)|	InChI=1S/C19H17F3N4O2/c1-11-15(3-2-7-23-11)26-16-9-12(19(20,21)22)4-5-14(16)17(24-18(26)28)25-8-6-13(27)10-25/h2-5,7,9,13,27H,6,8,10H2,1H3	SPKORSJNFQLTKS-UHFFFAOYSA-N	508059	US11046691, Compound 283::4-((3R)-3-hydroxypyrrolidinyl)-1-(2- methylpyridin-3-yl))-7- (trifluoromethyl)-hydroquinazolin-2- one::US11084798, Cpd No 283	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508059&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156541972	459093139							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071828	CNc1nc(=O)n(-c2cccnc2C)c2cc(ccc12)C(F)(F)F |(2.9,4.97,;1.54,4.26,;1.47,2.72,;2.77,1.89,;2.7,.36,;4,-.47,;1.33,-.36,;1.26,-1.89,;2.56,-2.72,;2.49,-4.26,;1.13,-4.97,;-.17,-4.14,;-.1,-2.6,;-1.4,-1.78,;.03,.47,;-1.33,-.24,;-2.63,.59,;-2.56,2.13,;-1.2,2.84,;.1,2.01,;-4,-.12,;-5.3,.71,;-4.07,-1.66,;-5.36,-.83,)|	InChI=1S/C16H13F3N4O/c1-9-12(4-3-7-21-9)23-13-8-10(16(17,18)19)5-6-11(13)14(20-2)22-15(23)24/h3-8H,1-2H3,(H,20,22,24)	UNOCQKFXBWHYFQ-UHFFFAOYSA-N	508062	US11130759, Cpd. No. 284::US11046691, Compound 284::1-(2-methylpyridin-3-yl))-4-(methyl- amino)-7-(trifluoromethyl)hydro- quinazolin-2-one::US11084798, Cpd No 284	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508062&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152944895	459093142							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071829	Cc1ncccc1-n1c2cc(ccc2c(N)nc1=O)C(F)(F)F |(-1.33,-1.54,;,-2.31,;,-3.85,;1.33,-4.62,;2.67,-3.85,;2.67,-2.31,;1.33,-1.54,;1.33,,;,.77,;-1.33,,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;1.33,3.08,;1.33,4.62,;2.67,2.31,;2.67,.77,;4,,;-4,,;-5.33,.77,;-4,-1.54,;-5.33,-.77,)|	InChI=1S/C15H11F3N4O/c1-8-11(3-2-6-20-8)22-12-7-9(15(16,17)18)4-5-10(12)13(19)21-14(22)23/h2-7H,1H3,(H2,19,21,23)	YWAIJQDIEQWPOX-UHFFFAOYSA-N	508065	US11130759, Cpd. No. 285::US11046691, Compound 285::4-amino-1-(2-methylpyridin-3-yl))-7- (trifluoromethyl)hydroquinazolin-2-one::US11084798, Cpd No 285	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508065&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149442483	459093145							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071830	FC(F)(F)c1ccc2c(nc(=O)n(-c3ccccc3Cl)c2n1)N1CCOCC1 |(-5.3,-.52,;-4,-1.34,;-4.06,-2.88,;-5.36,-2.06,;-2.64,-.62,;-2.58,.92,;-1.22,1.64,;.09,.82,;1.45,1.54,;2.75,.72,;2.69,-.82,;4,-1.64,;1.33,-1.54,;1.27,-3.08,;2.58,-3.9,;2.52,-5.44,;1.16,-6.16,;-.15,-5.34,;-.09,-3.8,;-1.39,-2.98,;.03,-.72,;-1.33,-1.44,;1.51,3.08,;2.87,3.8,;2.93,5.34,;1.62,6.16,;.26,5.44,;.2,3.9,)|	InChI=1S/C18H14ClF3N4O2/c19-12-3-1-2-4-13(12)26-16-11(5-6-14(23-16)18(20,21)22)15(24-17(26)27)25-7-9-28-10-8-25/h1-6H,7-10H2	ALQHJWPUQJPKCW-UHFFFAOYSA-N	508068	US11046691, Compound 286::1-(2-chlorophenyl)-4-morpholin-4-yl-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 286	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508068&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			146966696	459093148							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071831	NC(=O)CNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(3.09,6.27,;1.85,5.35,;.44,5.97,;2.03,3.82,;.79,2.91,;.97,1.38,;2.38,.76,;2.56,-.76,;3.97,-1.38,;1.32,-1.68,;1.5,-3.21,;2.91,-3.82,;3.09,-5.35,;1.86,-6.27,;.44,-5.66,;.27,-4.13,;-1.15,-3.52,;-.09,-1.07,;-1.32,-1.99,;-2.74,-1.38,;-2.91,.15,;-1.68,1.07,;-.27,.46,;-3.97,-2.3,;-5.39,-1.68,;-3.8,-3.83,;-5.21,-3.21,)|	InChI=1S/C16H11ClF3N5O2/c17-9-3-1-2-4-10(9)25-14-8(5-6-11(23-14)16(18,19)20)13(24-15(25)27)22-7-12(21)26/h1-6H,7H2,(H2,21,26)(H,22,24,27)	RBGXJHHCIYMDJE-UHFFFAOYSA-N	508071	US11130759, Cpd. No. 287::US11046691, Compound 287::2-((1-(2-chlorophenyl)-2-oxo-7- (trifluoromethyl)-1,2- dihydropyrido[2,3-d]pyrimidin-4- yl)amino)acetamide::US11084798, Cpd No 287	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508071&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			146709930	459093151							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071832	FC(F)(F)c1ccc2c(n1)n(-c1ccccc1Cl)c(=O)[nH]c2=O |(-5.33,.77,;-4,,;-4,-1.54,;-5.33,-.77,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;,.77,;-1.33,,;1.33,,;1.33,-1.54,;,-2.31,;,-3.85,;1.33,-4.62,;2.67,-3.85,;2.67,-2.31,;4,-1.54,;2.67,.77,;4,,;2.67,2.31,;1.33,3.08,;1.33,4.62,)|	InChI=1S/C14H7ClF3N3O2/c15-8-3-1-2-4-9(8)21-11-7(12(22)20-13(21)23)5-6-10(19-11)14(16,17)18/h1-6H,(H,20,22,23)	IGXCAMPXSFVRBQ-UHFFFAOYSA-N	508051	US11130759, Cpd. No. 388::US11046691, Compound 388::1-(2-chlorophenyl)-7-(trifluoromethyl)- 1,3-dihydropyridino[2,3-d]pyrimidine- 2,4-dione::US11084798, Cpd No 288	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508051&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370676	459093131							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071833	Oc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(C3=CCNC3)c12 |t:19|	InChI=1S/C18H14ClN3O2/c19-12-8-14(11-6-7-20-10-11)16-15(9-12)22(18(24)21-17(16)23)13-4-2-1-3-5-13/h1-6,8-9,20H,7,10H2,(H,21,23,24)	RQVYDCYNYZAZLB-UHFFFAOYSA-N	508077	US11130759, Cpd. No. 289::US11046691, Compound 289::7-chloro-5-(2,5-dihydro-1H-pyrrol-3- yl)-4-hydroxy-1-phenylquinazolin- 2(1H)-one::US11084798, Cpd No 289	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508077&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514057	459093157							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071834	CC(C)(C)OC(=O)N1CC=C(C1)c1cc(Cl)cc2n(-c3ccccc3)c(=O)nc(O)c12 |c:9|	InChI=1S/C23H22ClN3O4/c1-23(2,3)31-22(30)26-10-9-14(13-26)17-11-15(24)12-18-19(17)20(28)25-21(29)27(18)16-7-5-4-6-8-16/h4-9,11-12H,10,13H2,1-3H3,(H,25,28,29)	FBFMDAXEWAEQCH-UHFFFAOYSA-N	508080	US11130759, Cpd. No. 290::US11046691, Compound 290::tert-butyl 3-(7-chloro-4-hydroxy-2-oxo- 1-phenyl-1,2-dihydroquinazolin-5-yl)- 2,5-dihydro-1H-pyrrole-1-carboxylate::US11084798, Cpd No 290	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508080&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514018	459093160							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071835	Oc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(-c3ccncc3)c12	InChI=1S/C19H12ClN3O2/c20-13-10-15(12-6-8-21-9-7-12)17-16(11-13)23(19(25)22-18(17)24)14-4-2-1-3-5-14/h1-11H,(H,22,24,25)	DNLDDCZEDRCSDM-UHFFFAOYSA-N	508083	US11130759, Cpd. No. 291::US11046691, Compound 291::7-chloro-4-hydroxy-1-phenyl-5- (pyridin-4-yl)quinazolin-2(1H)-one::US11084798, Cpd No 291	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508083&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608788	459093163							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071836	C[C@H](O)CNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wD:1.1,(1.54,6.07,;2.91,5.38,;4.2,6.23,;3,3.84,;1.71,3,;1.8,1.46,;3.18,.77,;3.26,-.77,;4.64,-1.46,;1.98,-1.61,;2.06,-3.15,;.78,-4,;.86,-5.53,;2.24,-6.23,;3.53,-5.38,;3.44,-3.84,;4.73,-3,;.6,-.92,;-.69,-1.76,;-2.06,-1.07,;-2.15,.47,;-.86,1.31,;.51,.62,;-3.35,-1.92,;-3.26,-3.45,;-4.73,-1.22,;-4.64,-2.76,)|	InChI=1S/C17H14ClF3N4O2/c1-9(26)8-22-14-10-6-7-13(17(19,20)21)23-15(10)25(16(27)24-14)12-5-3-2-4-11(12)18/h2-7,9,26H,8H2,1H3,(H,22,24,27)	GOBXBOUBFJQYGL-UHFFFAOYSA-N	508088	US11130759, Cpd. No. 293::US11046691, Compound 293::4-[((2S)-2-hydroxypropyl)amino]-1-(2- chlorophenyl)-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 293	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508088&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514026	459093167							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071837	C[C@@H](O)CNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.1,(1.33,6.16,;2.67,5.39,;4,6.16,;2.67,3.85,;1.33,3.08,;1.33,1.54,;2.67,.77,;2.67,-.77,;4,-1.54,;1.33,-1.54,;1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;2.67,-5.39,;2.67,-3.85,;4,-3.08,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;,.77,;-4,-1.54,;-5.33,-.77,;-4,-3.08,;-5.33,-2.31,)|	InChI=1S/C17H14ClF3N4O2/c1-9(26)8-22-14-10-6-7-13(17(19,20)21)23-15(10)25(16(27)24-14)12-5-3-2-4-11(12)18/h2-7,9,26H,8H2,1H3,(H,22,24,27)	GOBXBOUBFJQYGL-UHFFFAOYSA-N	508091	US11130759, Cpd. No. 294::US11046691, Compound 294::4-[((2R)-2-hydroxypropyl)amino]-1-(2- chlorophenyl)-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 294	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508091&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514031	459093170							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071838	OC1(CNc2nc(=O)c(-c3ccccc3Cl)c3[nH]c(ccc23)C(F)(F)F)CC1 |(3.68,5.96,;2.38,5.14,;2.43,3.61,;1.13,2.79,;1.19,1.25,;2.55,.53,;2.61,-1.01,;3.97,-1.73,;1.3,-1.83,;1.36,-3.37,;.06,-4.19,;.12,-5.73,;1.48,-6.45,;2.78,-5.63,;2.72,-4.09,;4.03,-3.27,;-.06,-1.11,;-1.36,-1.93,;-2.72,-1.21,;-2.78,.33,;-1.48,1.15,;-.12,.43,;-4.03,-2.03,;-5.39,-1.31,;-3.97,-3.57,;-5.33,-2.85,;1.56,6.45,;.84,5.09,)|	InChI=1S/C19H15ClF3N3O2/c20-12-4-2-1-3-10(12)14-15-11(5-6-13(25-15)19(21,22)23)16(26-17(14)27)24-9-18(28)7-8-18/h1-6,25,28H,7-9H2,(H,24,26,27)	LGZRIRVKTSJGNR-UHFFFAOYSA-N	511961	US11084798, Cpd No 295::1-(2-chlorophenyl)-4-{[(hydroxycyclo- propyl)methyl]amino}-7-(trifluoro- methyl)-pyrido[2,3-d]pyrimidin-2(1H)- one	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=511961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=511961&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162678136	459629212							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071839	OCCNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(4.13,6.11,;2.77,5.39,;2.72,3.85,;1.36,3.12,;1.31,1.59,;2.61,.77,;2.56,-.77,;3.86,-1.59,;1.2,-1.49,;1.14,-3.03,;-.22,-3.75,;-.27,-5.29,;1.04,-6.11,;2.4,-5.39,;2.45,-3.85,;3.81,-3.12,;-.11,-.68,;-1.47,-1.4,;-2.77,-.58,;-2.72,.96,;-1.36,1.68,;-.05,.86,;-4.13,-1.31,;-5.44,-.49,;-4.19,-2.85,;-5.49,-2.03,)|	InChI=1S/C16H12ClF3N4O2/c17-10-3-1-2-4-11(10)24-14-9(5-6-12(22-14)16(18,19)20)13(21-7-8-25)23-15(24)26/h1-6,25H,7-8H2,(H,21,23,26)	AAIIQHLPZWPVDW-UHFFFAOYSA-N	508096	US11130759, Cpd. No. 296::US11046691, Compound 296::1-(2-chlorophenyl)-4-[(2-hydroxy- Iethyl)amino]-7-(trifluoromethyl) pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 296	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508096&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608348	459093175							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071840	OC12CC(C1)(C2)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(4.94,5.93,;3.61,5.16,;3.21,3.68,;1.72,4.08,;2.12,5.56,;2.47,5.07,;.39,3.31,;.39,1.77,;1.72,1,;1.72,-.54,;3.06,-1.31,;.39,-1.31,;.39,-2.85,;-.94,-3.62,;-.94,-5.16,;.39,-5.93,;1.72,-5.16,;1.72,-3.62,;3.06,-2.85,;-.94,-.54,;-2.28,-1.31,;-3.61,-.54,;-3.61,1,;-2.28,1.77,;-.94,1,;-4.94,-1.31,;-6.28,-.54,;-4.94,-2.85,;-6.28,-2.08,)|	InChI=1S/C19H14ClF3N4O2/c20-11-3-1-2-4-12(11)27-15-10(5-6-13(24-15)19(21,22)23)14(25-16(27)28)26-17-7-18(29,8-17)9-17/h1-6,29H,7-9H2,(H,25,26,28)	JZXFEGIFJLGEGN-UHFFFAOYSA-N	508099	US11130759, Cpd. No. 297::US11046691, Compound 297::1-(2-chlorophenyl)-4-[(3-hydroxy- bicyclo[1.1.1]pentyl)amino]-7- (trifluoro-methyl)-pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 297	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508099&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608310	459093178							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071841	FC(F)(F)c1ccc2c(n1)n(-c1ccccc1Cl)c(=O)[nH]c2=O |(-5.33,.77,;-4,,;-4,-1.54,;-5.33,-.77,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;,.77,;-1.33,,;1.33,,;1.33,-1.54,;,-2.31,;,-3.85,;1.33,-4.62,;2.67,-3.85,;2.67,-2.31,;4,-1.54,;2.67,.77,;4,,;2.67,2.31,;1.33,3.08,;1.33,4.62,)|	InChI=1S/C14H7ClF3N3O2/c15-8-3-1-2-4-9(8)21-11-7(12(22)20-13(21)23)5-6-10(19-11)14(16,17)18/h1-6H,(H,20,22,23)	IGXCAMPXSFVRBQ-UHFFFAOYSA-N	508051	US11130759, Cpd. No. 388::US11046691, Compound 388::1-(2-chlorophenyl)-7-(trifluoromethyl)- 1,3-dihydropyridino[2,3-d]pyrimidine- 2,4-dione::US11084798, Cpd No 288	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508051&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370676	459093131							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071842	O[C@]1(C[C@@H](C1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F)C(F)(F)F |r,wU:1.0,wD:3.5,1.31,(3.39,6.29,;2.99,4.81,;2.59,3.32,;1.1,3.72,;1.5,5.2,;-.23,2.95,;-.23,1.41,;1.1,.64,;1.1,-.9,;2.44,-1.67,;-.23,-1.67,;-.23,-3.21,;-1.56,-3.98,;-1.56,-5.52,;-.23,-6.29,;1.1,-5.52,;1.1,-3.98,;2.44,-3.21,;-1.56,-.9,;-2.9,-1.67,;-4.23,-.9,;-4.23,.64,;-2.9,1.41,;-1.56,.64,;-5.57,-1.67,;-6.9,-.9,;-5.57,-3.21,;-6.9,-2.44,;4.48,4.41,;4.88,2.92,;3.39,3.32,;5.57,5.5,)|	InChI=1S/C19H13ClF6N4O2/c20-11-3-1-2-4-12(11)30-15-10(5-6-13(28-15)18(21,22)23)14(29-16(30)31)27-9-7-17(32,8-9)19(24,25)26/h1-6,9,32H,7-8H2,(H,27,29,31)	QZDSJFRFBJGPAM-UHFFFAOYSA-N	508104	US11130759, Cpd. No. 299::US11046691, Compound 299::4-1[(trans)-3-hydroxy-3-(trifluoro- methyl)cyclobutyl]amino}-1-1-(2- chlorophenyl)-7- (trifluoromethyl)pyrido-[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 299	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508104&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608287	459093183							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071843	C[C@]1(O)C[C@@H](C1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.1,wD:4.6,1.0,(-5.27,-2.58,;-4.87,-1.09,;-6.35,-.69,;-4.47,.4,;-2.98,,;-3.38,-1.49,;-1.65,.77,;-.31,,;-.31,-1.54,;1.02,-2.31,;1.02,-3.85,;2.35,-1.54,;3.69,-2.31,;5.02,-1.54,;6.35,-2.31,;6.35,-3.85,;5.02,-4.62,;3.69,-3.85,;2.35,-4.62,;2.35,,;3.69,.77,;3.69,2.31,;2.35,3.08,;1.02,2.31,;1.02,.77,;5.02,3.08,;6.35,2.31,;5.02,4.62,;6.35,3.85,)|	InChI=1S/C19H16ClF3N4O2/c1-18(29)8-10(9-18)24-15-11-6-7-14(19(21,22)23)25-16(11)27(17(28)26-15)13-5-3-2-4-12(13)20/h2-7,10,29H,8-9H2,1H3,(H,24,26,28)	HORDOUGRQWGGKG-UHFFFAOYSA-N	508107	US11130759, Cpd. No. 300::US11046691, Compound 300::4-[((trans)-3-hydroxy-3-methylcyclo- butyl)amino]-1-(2-chlorophenyl)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 300	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508107	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508107&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608547	459093186							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071844	CO[C@H]1C[C@@H](C1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:2.1,wD:4.6,(4.76,6.78,;4.81,5.24,;3.51,4.42,;3.16,2.92,;1.66,3.27,;2.01,4.77,;.36,2.45,;.41,.92,;1.77,.19,;1.82,-1.35,;3.18,-2.07,;.52,-2.16,;.57,-3.7,;-.74,-4.52,;-.68,-6.06,;.68,-6.78,;1.98,-5.96,;1.93,-4.42,;3.24,-3.61,;-.84,-1.44,;-2.15,-2.26,;-3.51,-1.53,;-3.56,.01,;-2.26,.82,;-.9,.1,;-4.81,-2.35,;-6.17,-1.63,;-4.76,-3.89,;-6.12,-3.16,)|	InChI=1S/C19H16ClF3N4O2/c1-29-11-8-10(9-11)24-16-12-6-7-15(19(21,22)23)25-17(12)27(18(28)26-16)14-5-3-2-4-13(14)20/h2-7,10-11H,8-9H2,1H3,(H,24,26,28)	NJFQRSUSEQSSCD-UHFFFAOYSA-N	508110	US11130759, Cpd. No. 301::US11046691, Compound 301::4-[(trans)-3-methoxycyclobutyl)amino]- 1-(2-chlorophenyl)-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 301	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508110&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608247	459093189							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071845	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(c(Br)cc12)C(F)(F)F |(2.85,4.98,;1.49,4.26,;1.44,2.72,;2.75,1.9,;2.69,.36,;4,-.45,;1.33,-.36,;1.28,-1.9,;2.59,-2.72,;2.53,-4.26,;1.17,-4.98,;-.13,-4.16,;-.08,-2.62,;-1.39,-1.81,;.03,.45,;-1.33,-.27,;-2.64,.55,;-2.59,2.09,;-3.89,2.9,;-1.23,2.81,;.08,1.99,;-4,-.18,;-5.3,.64,;-4.05,-1.71,;-5.36,-.9,)|	InChI=1S/C16H10BrClF3N3O/c1-22-14-8-6-10(17)9(16(19,20)21)7-13(8)24(15(25)23-14)12-5-3-2-4-11(12)18/h2-7H,1H3,(H,22,23,25)	KPCCOZRKHGIHHJ-UHFFFAOYSA-N	508113	US11130759, Cpd. No. 302::US11046691, Compound 302::6-bromo-1-(2-chlorophenyl)-4- (methylamino)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 302	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508113&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148238090	459093192							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071846	CNc1nc(=O)n(-c2ccccc2)c2cc(c(Br)cc12)C(F)(F)F	InChI=1S/C16H11BrF3N3O/c1-21-14-10-7-12(17)11(16(18,19)20)8-13(10)23(15(24)22-14)9-5-3-2-4-6-9/h2-8H,1H3,(H,21,22,24)	RGLNQSXEUBWYOC-UHFFFAOYSA-N	508116	US11130759, Cpd. No. 303::US11046691, Compound 303::6-bromo-4-(methylamino)-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 303	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508116&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151710500	459093195							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071847	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(c(F)cc12)C(F)(F)F |(3.22,4.91,;1.81,4.28,;1.65,2.75,;2.89,1.84,;2.73,.31,;3.98,-.59,;1.33,-.31,;1.17,-1.84,;2.41,-2.75,;2.25,-4.28,;.84,-4.91,;-.4,-4,;-.24,-2.47,;-1.49,-1.57,;.08,.59,;-1.33,-.03,;-2.57,.87,;-2.41,2.4,;-3.66,3.31,;-1,3.03,;.24,2.12,;-3.98,.24,;-5.22,1.15,;-4.14,-1.29,;-5.39,-.38,)|	InChI=1S/C16H10ClF4N3O/c1-22-14-8-6-11(18)9(16(19,20)21)7-13(8)24(15(25)23-14)12-5-3-2-4-10(12)17/h2-7H,1H3,(H,22,23,25)	QQTRKIZOZZGKLJ-UHFFFAOYSA-N	507784	US11130759, Cpd. No. 304::US11046691, Compound 304::1-(2-chlorophenyl)-6-fluoro-4-(methyl- amino)-7-(trifluoromethyl)hydro- quinazolin-2-one::US11084798, Cpd No 304	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507784&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608532	459092869							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071848	Clc1ccc2c(c1)n(-c1cccc3nc[nH]c13)c(=O)[nH]c2=O |(-3.99,.46,;-2.59,1.12,;-2.46,2.65,;-1.06,3.3,;.2,2.42,;.07,.88,;-1.33,.23,;1.33,,;1.19,-1.53,;2.46,-2.42,;2.32,-3.95,;.93,-4.6,;-.34,-3.72,;-1.84,-4.07,;-2.63,-2.75,;-1.62,-1.58,;-.2,-2.18,;2.72,.65,;3.99,-.23,;2.86,2.18,;1.6,3.07,;1.73,4.6,)|	InChI=1S/C15H9ClN4O2/c16-8-4-5-9-12(6-8)20(15(22)19-14(9)21)11-3-1-2-10-13(11)18-7-17-10/h1-7H,(H,17,18)(H,19,21,22)	UZSOJOHNPIAYBM-UHFFFAOYSA-N	507789	US11130759, Cpd. No. 305::US11046691, Compound 305::1-benzimidazol-7-yl-7-chloro-1,3- dihydroquinazoline-2,4-dione::US11084798, Cpd No 305	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507789&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370648	459092874							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071849	CN(C)c1nc(=O)n(-c2ccc3[nH]cnc3c2)c2cc(Cl)ccc12	InChI=1S/C17H14ClN5O/c1-22(2)16-12-5-3-10(18)7-15(12)23(17(24)21-16)11-4-6-13-14(8-11)20-9-19-13/h3-9H,1-2H3,(H,19,20)	GAFFOONTELSKSP-UHFFFAOYSA-N	507793	US11130759, Cpd. No. 306::US11046691, Compound 306::1-benzimidazol-5-yl-4- (dimethylamino)-7- chlorohydroquinazolin-2-one::US11084798, Cpd No 306	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507793&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608633	459092878							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071850	CNc1nc(=O)n(-c2ccc3[nH]cnc3c2)c2cc(Cl)ccc12	InChI=1S/C16H12ClN5O/c1-18-15-11-4-2-9(17)6-14(11)22(16(23)21-15)10-3-5-12-13(7-10)20-8-19-12/h2-8H,1H3,(H,19,20)(H,18,21,23)	QKHVPQGYJVJXFX-UHFFFAOYSA-N	507797	US11130759, Cpd. No. 307::US11046691, Compound 307::1-benzimidazol-5-yl-7-chloro-4- (methyl-amino)hydroquinazolin-2-one::US11084798, Cpd No 307	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507797&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608323	459092882							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071851	FC(F)(F)c1ccc2c(NC3CC3)nc(=O)n(-c3ccccc3Cl)c2n1 |(-5.44,-.28,;-4.1,-1.05,;-4.1,-2.59,;-5.44,-1.82,;-2.77,-.28,;-2.77,1.26,;-1.44,2.03,;-.1,1.26,;1.23,2.03,;1.23,3.57,;2.56,4.34,;4.1,4.34,;3.33,5.67,;2.56,1.26,;2.56,-.28,;3.9,-1.05,;1.23,-1.05,;1.23,-2.59,;2.56,-3.36,;2.56,-4.9,;1.23,-5.67,;-.1,-4.9,;-.1,-3.36,;-1.44,-2.59,;-.1,-.28,;-1.44,-1.05,)|	InChI=1S/C17H12ClF3N4O/c18-11-3-1-2-4-12(11)25-15-10(7-8-13(23-15)17(19,20)21)14(24-16(25)26)22-9-5-6-9/h1-4,7-9H,5-6H2,(H,22,24,26)	CETWSARLGHQRHN-UHFFFAOYSA-N	507801	US11130759, Cpd. No. 308::US11046691, Compound 308::1-(2-chlorophenyl)-4-(cyclopropyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 308	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507801&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608939	459092886							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071852	CNc1nc(=O)n(-c2ncccn2)c2cc(ccc12)C1CC1	InChI=1S/C16H15N5O/c1-17-14-12-6-5-11(10-3-4-10)9-13(12)21(16(22)20-14)15-18-7-2-8-19-15/h2,5-10H,3-4H2,1H3,(H,17,20,22)	BIBZUKGJNPEFPL-UHFFFAOYSA-N	507805	US11130759, Cpd. No. 309::US11046691, Compound 309::7-cyclopropyl-4-(methylamino)-1- pyrimidin-2-ylhydroquinazolin-2-one::US11084798, Cpd No 309	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507805&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608332	459092890							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071853	CNc1nc(=O)n(-c2ccc(F)c(O)c2)c2cc(Cl)ccc12	InChI=1S/C15H11ClFN3O2/c1-18-14-10-4-2-8(16)6-12(10)20(15(22)19-14)9-3-5-11(17)13(21)7-9/h2-7,21H,1H3,(H,18,19,22)	YJKGHGZZAQXOLF-UHFFFAOYSA-N	507809	US11130759, Cpd. No. 310::US11046691, Compound 310::7-chloro-1-(4-fluoro-3-hydroxyphenyl)- 4-(methylamino)hydroquinazolin-2-one::US11084798, Cpd No 310	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507809&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608731	459092894							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071854	COc1ccc(F)c(c1)-n1c2cc(Cl)ccc2c(=O)[nH]c1=O |(4.67,-3.85,;3.33,-4.62,;2,-3.85,;.67,-4.62,;-.67,-3.85,;-.67,-2.31,;-2,-1.54,;.67,-1.54,;2,-2.31,;.67,,;-.67,.77,;-2,,;-3.33,.77,;-4.67,,;-3.33,2.31,;-2,3.08,;-.67,2.31,;.67,3.08,;.67,4.62,;2,2.31,;2,.77,;3.33,,)|	InChI=1S/C15H10ClFN2O3/c1-22-9-3-5-11(17)13(7-9)19-12-6-8(16)2-4-10(12)14(20)18-15(19)21/h2-7H,1H3,(H,18,20,21)	BNIIFZKVMVJBBF-UHFFFAOYSA-N	507813	US11130759, Cpd. No. 311::US11046691, Compound 311::7-chloro-1-(2-fluoro-5- methoxyphenyl)-quinazoline- 2,4(1H,3H)-dione::US11084798, Cpd No 311	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507813&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370649	459092898							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071855	CNc1nc(=O)n(-c2ccncc2Cl)c2nc(ccc12)C(F)(F)F |(2.45,5.03,;1.14,4.21,;1.2,2.67,;2.56,1.95,;2.61,.41,;3.97,-.31,;1.31,-.41,;1.36,-1.95,;.05,-2.76,;.11,-4.3,;1.47,-5.03,;2.77,-4.21,;2.72,-2.67,;4.03,-1.85,;-.05,.31,;-1.36,-.5,;-2.72,.22,;-2.77,1.76,;-1.47,2.58,;-.11,1.85,;-4.03,-.59,;-5.39,.13,;-3.97,-2.13,;-5.33,-1.41,)|	InChI=1S/C14H9ClF3N5O/c1-19-11-7-2-3-10(14(16,17)18)21-12(7)23(13(24)22-11)9-4-5-20-6-8(9)15/h2-6H,1H3,(H,19,22,24)	LADWQKGTOIZTJV-UHFFFAOYSA-N	507817	US11130759, Cpd. No. 312::US11046691, Compound 312::1-(3-chloro-pyridin-4-yl))-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 312	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507817&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608588	459092902							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071856	CNc1nc(=O)n(-c2ccncc2)c2nc(ccc12)C(F)(F)F	InChI=1S/C14H10F3N5O/c1-18-11-9-2-3-10(14(15,16)17)20-12(9)22(13(23)21-11)8-4-6-19-7-5-8/h2-7H,1H3,(H,18,21,23)	GGKVLHHMJQIADC-UHFFFAOYSA-N	507821	US11130759, Cpd. No. 313::US11046691, Compound 313::4-(methylamino)-1-(pyridin-4-yl))-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 313	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507821&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156541973	459092906							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071857	CNc1nc(=O)n(-c2ccc(C)nc2)c2nc(ccc12)C(F)(F)F	InChI=1S/C15H12F3N5O/c1-8-3-4-9(7-20-8)23-13-10(12(19-2)22-14(23)24)5-6-11(21-13)15(16,17)18/h3-7H,1-2H3,(H,19,22,24)	RUPKWBWYQQIMSI-UHFFFAOYSA-N	507824	US11130759, Cpd. No. 314::US11046691, Compound 314::1-(6-methyl--pyridin-3-yl))-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 314	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507824&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156541984	459092909							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071858	FC1CC(C1)c1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(1.85,6.47,;1.76,4.93,;2.78,3.77,;1.62,2.76,;.6,3.91,;1.52,1.22,;2.81,.37,;2.71,-1.17,;3.99,-2.02,;1.33,-1.86,;1.23,-3.39,;-.14,-4.08,;-.24,-5.61,;1.04,-6.47,;2.42,-5.78,;2.52,-4.24,;3.9,-3.56,;.05,-1,;-1.33,-1.69,;-2.61,-.84,;-2.52,.7,;-1.14,1.39,;.14,.53,;-3.99,-1.52,;-5.28,-.67,;-4.09,-3.06,;-5.37,-2.21,)|	InChI=1S/C18H12ClF4N3O/c19-12-3-1-2-4-13(12)26-16-11(5-6-14(24-16)18(21,22)23)15(25-17(26)27)9-7-10(20)8-9/h1-6,9-10H,7-8H2	OQKGCWSLLMPVKQ-UHFFFAOYSA-N	511980	US11084798, Cpd No 315::1-(2-chlorophenyl)-4-(3-fluoroazetidin- 1-yl)-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=511980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=511980&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162533553	459629231							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071859	FC(F)(F)c1ccc2c(NC3CC4(C3)CS(=O)(=O)C4)nc(=O)n(-c3ccccc3Cl)c2n1 |(-7.07,-1.96,;-5.7,-2.66,;-5.62,-4.19,;-6.99,-3.5,;-4.41,-1.82,;-4.49,-.28,;-3.2,.56,;-1.83,-.14,;-.53,.7,;-.62,2.24,;.68,3.08,;2.18,2.76,;2.5,4.26,;1,4.58,;4.01,3.94,;4.33,5.45,;5.7,4.75,;4.33,6.99,;2.82,5.77,;.84,0,;.92,-1.54,;2.29,-2.24,;-.37,-2.38,;-.29,-3.91,;-1.58,-4.75,;-1.5,-6.29,;-.13,-6.99,;1.16,-6.15,;1.08,-4.61,;2.37,-3.77,;-1.75,-1.68,;-3.04,-2.52,)|	InChI=1S/C20H16ClF3N4O3S/c21-13-3-1-2-4-14(13)28-17-12(5-6-15(26-17)20(22,23)24)16(27-18(28)29)25-11-7-19(8-11)9-32(30,31)10-19/h1-6,11H,7-10H2,(H,25,27,29)	ZGIAXHVVQRTLQP-UHFFFAOYSA-N	507832	US11130759, Cpd. No. 316::US11046691, Compound 316::1-(2-chlorophenyl)-4-((2,2-dioxido-2- thiaspiro[3.3]heptan-6-yl)amino)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 316	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507832&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514035	459092917							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071860	COCCNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(3.14,7.02,;3.27,5.48,;2,4.6,;2.14,3.07,;.87,2.19,;1,.65,;2.4,,;2.53,-1.53,;3.92,-2.19,;1.26,-2.41,;1.39,-3.95,;.13,-4.83,;.26,-6.36,;1.66,-7.02,;2.92,-6.14,;2.79,-4.6,;4.05,-3.72,;-.13,-1.76,;-1.39,-2.64,;-2.79,-1.99,;-2.92,-.45,;-1.66,.43,;-.26,-.23,;-4.05,-2.87,;-5.45,-2.21,;-3.92,-4.4,;-5.32,-3.75,)|	InChI=1S/C17H14ClF3N4O2/c1-27-9-8-22-14-10-6-7-13(17(19,20)21)23-15(10)25(16(26)24-14)12-5-3-2-4-11(12)18/h2-7H,8-9H2,1H3,(H,22,24,26)	AHSXYZBRSQLFRV-UHFFFAOYSA-N	507835	US11130759, Cpd. No. 317::US11046691, Compound 317::1-(2-chlorophenyl)-4-[(2- methoxyethyl)-amino]-7- (trifluoromethyl)pyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 317	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507835&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514033	459092920							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071861	FC(F)(F)c1ccc2c(N[C@H]3C[C@H](C3)C#N)nc(=O)n(-c3ccccc3Cl)c2n1 |r,wD:10.9,12.14,(-7.1,-.44,;-5.81,-1.28,;-5.89,-2.81,;-7.18,-1.98,;-4.44,-.58,;-4.36,.96,;-2.99,1.66,;-1.69,.83,;-.32,1.53,;-.24,3.07,;1.13,3.77,;2.59,3.29,;3.07,4.76,;1.6,5.23,;4.44,5.46,;5.81,6.16,;.97,.69,;.89,-.85,;2.18,-1.68,;-.48,-1.55,;-.56,-3.09,;-1.93,-3.79,;-2.01,-5.32,;-.71,-6.16,;.66,-5.46,;.73,-3.92,;2.11,-3.22,;-1.77,-.71,;-3.14,-1.41,)|	InChI=1S/C19H13ClF3N5O/c20-13-3-1-2-4-14(13)28-17-12(5-6-15(26-17)19(21,22)23)16(27-18(28)29)25-11-7-10(8-11)9-24/h1-6,10-11H,7-8H2,(H,25,27,29)	QZDHHHANUPYLSP-UHFFFAOYSA-N	507839	US11130759, Cpd. No. 318::US11046691, Compound 318::(1s,3s)-3-((1-(2-chlorophenyl)-2-oxo-7- (trifluoromethyl)-1,2- dihydropyrido[2,3-d]pyrimidin-4- yl)amino)cyclobutane-1-carbonitrile::US11084798, Cpd No 318	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507839&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514023	459092924							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071862	CC1(CCC1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(1.44,5.37,;2.48,4.24,;3.95,3.77,;4.42,5.24,;2.95,5.71,;1.12,3.53,;1.05,1.99,;2.35,1.16,;2.28,-.38,;3.58,-1.21,;.91,-1.09,;.85,-2.63,;-.52,-3.34,;-.59,-4.88,;.71,-5.71,;2.08,-4.99,;2.14,-3.46,;3.51,-2.75,;-.38,-.26,;-1.75,-.97,;-3.05,-.14,;-2.98,1.39,;-1.62,2.1,;-.32,1.28,;-4.42,-.86,;-5.71,-.03,;-4.48,-2.39,;-5.78,-1.57,)|	InChI=1S/C19H16ClF3N4O/c1-18(9-4-10-18)26-15-11-7-8-14(19(21,22)23)24-16(11)27(17(28)25-15)13-6-3-2-5-12(13)20/h2-3,5-8H,4,9-10H2,1H3,(H,25,26,28)	XGLVANYOJZIOKG-UHFFFAOYSA-N	507843	US11130759, Cpd. No. 319::US11046691, Compound 319::1-(2-chlorophenyl)-4-[(methylcyclo- buty)amino]-7-(trifluoromethyppyrido- [2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 319	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507843&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933488	459092928							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071863	FC(F)(F)c1ccc2c(NC3CCC3)nc(=O)n(-c3ccccc3Cl)c2n1 |(-5.65,-.23,;-4.33,-1.02,;-4.36,-2.56,;-5.68,-1.77,;-2.99,-.27,;-2.96,1.27,;-1.61,2.01,;-.29,1.22,;1.05,1.97,;1.08,3.51,;2.43,4.25,;3.91,3.83,;4.33,5.31,;2.85,5.73,;2.37,1.17,;2.35,-.37,;3.67,-1.16,;1,-1.11,;.97,-2.65,;-.37,-3.4,;-.4,-4.94,;.92,-5.73,;2.27,-4.99,;2.29,-3.45,;3.64,-2.7,;-.32,-.32,;-1.67,-1.07,)|	InChI=1S/C18H14ClF3N4O/c19-12-6-1-2-7-13(12)26-16-11(8-9-14(24-16)18(20,21)22)15(25-17(26)27)23-10-4-3-5-10/h1-2,6-10H,3-5H2,(H,23,25,27)	KUPLUKWRRSBDQU-UHFFFAOYSA-N	507847	US11130759, Cpd. No. 320::US11046691, Compound 320::1-(2-chlorophenyl)-4- (cyclobutylamino)-7- (trifluoromethyl)pyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 320	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507847&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608578	459092932							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071864	O[C@H]1C[C@H](C1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:3.5,1.0,(4.94,5.93,;3.61,5.16,;3.21,3.68,;1.72,4.08,;2.12,5.56,;.39,3.31,;.39,1.77,;1.72,1,;1.72,-.54,;3.06,-1.31,;.39,-1.31,;.39,-2.85,;-.94,-3.62,;-.94,-5.16,;.39,-5.93,;1.72,-5.16,;1.72,-3.62,;3.06,-2.85,;-.94,-.54,;-2.28,-1.31,;-3.61,-.54,;-3.61,1,;-2.28,1.77,;-.94,1,;-4.94,-1.31,;-6.28,-.54,;-4.94,-2.85,;-6.28,-2.08,)|	InChI=1S/C18H14ClF3N4O2/c19-12-3-1-2-4-13(12)26-16-11(5-6-14(24-16)18(20,21)22)15(25-17(26)28)23-9-7-10(27)8-9/h1-6,9-10,27H,7-8H2,(H,23,25,28)	FVEINZLDKQGZPA-UHFFFAOYSA-N	507850	US11130759, Cpd. No. 321::US11046691, Compound 321::(1s,3s)-3-((1-(2-chlorophenyl)-2-oxo-7- (trifluoromethyl)-1,2- dihydropyrido[2,3-d]pyrimidin-4- yl)amino)cyclobutane-1-carbonitrile::US11084798, Cpd No 321	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507850&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608468	459092935							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071865	OCC1(CC1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(3.9,6.16,;2.56,5.39,;2.56,3.85,;3.33,2.52,;4.1,3.85,;1.23,3.08,;1.23,1.54,;2.56,.77,;2.56,-.77,;3.9,-1.54,;1.23,-1.54,;1.23,-3.08,;-.1,-3.85,;-.1,-5.39,;1.23,-6.16,;2.56,-5.39,;2.56,-3.85,;3.9,-3.08,;-.1,-.77,;-1.44,-1.54,;-2.77,-.77,;-2.77,.77,;-1.44,1.54,;-.1,.77,;-4.1,-1.54,;-5.44,-.77,;-4.1,-3.08,;-5.44,-2.31,)|	InChI=1S/C18H14ClF3N4O2/c19-11-3-1-2-4-12(11)26-15-10(5-6-13(23-15)18(20,21)22)14(24-16(26)28)25-17(9-27)7-8-17/h1-6,27H,7-9H2,(H,24,25,28)	XRFQQIMKHRWHMD-UHFFFAOYSA-N	507853	US11130759, Cpd. No. 322::US11046691, Compound 322::1-(2-chlorophenyl)-4-{[(hydroxy- methyl)cyclopropyl]amino}-7- (trifluoro-methyl)-pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 322	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507853&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608325	459092938							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071866	C[C@H](CO)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.0,(4,3.08,;2.67,3.85,;2.67,5.39,;4,6.16,;1.33,3.08,;1.33,1.54,;2.67,.77,;2.67,-.77,;4,-1.54,;1.33,-1.54,;1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;2.67,-5.39,;2.67,-3.85,;4,-3.08,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;,.77,;-4,-1.54,;-5.33,-.77,;-4,-3.08,;-5.33,-2.31,)|	InChI=1S/C17H14ClF3N4O2/c1-9(8-26)22-14-10-6-7-13(17(19,20)21)23-15(10)25(16(27)24-14)12-5-3-2-4-11(12)18/h2-7,9,26H,8H2,1H3,(H,22,24,27)	NNBLPRBYZBYTJP-UHFFFAOYSA-N	507856	US11130759, Cpd. No. 324::US11046691, Compound 324::(R)-(1Sa)-(2-chlorophenyl)-4-((1- hydroxypropan-2-yl)amino)-7- (trifluoro-methyl)pyrido-[2,3- d]pyrimidin-2(1H)-one::US11046691, Compound 323::US11084798, Cpd No 324	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507856&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608894	459092941							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071867	C[C@H](CO)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.0,(4,3.08,;2.67,3.85,;2.67,5.39,;4,6.16,;1.33,3.08,;1.33,1.54,;2.67,.77,;2.67,-.77,;4,-1.54,;1.33,-1.54,;1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;2.67,-5.39,;2.67,-3.85,;4,-3.08,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;,.77,;-4,-1.54,;-5.33,-.77,;-4,-3.08,;-5.33,-2.31,)|	InChI=1S/C17H14ClF3N4O2/c1-9(8-26)22-14-10-6-7-13(17(19,20)21)23-15(10)25(16(27)24-14)12-5-3-2-4-11(12)18/h2-7,9,26H,8H2,1H3,(H,22,24,27)	NNBLPRBYZBYTJP-UHFFFAOYSA-N	507856	US11130759, Cpd. No. 324::US11046691, Compound 324::(R)-(1Sa)-(2-chlorophenyl)-4-((1- hydroxypropan-2-yl)amino)-7- (trifluoro-methyl)pyrido-[2,3- d]pyrimidin-2(1H)-one::US11046691, Compound 323::US11084798, Cpd No 324	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507856&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608894	459092941							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071868	FC(F)CNc1nc(=O)n(-c2cccnc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C16H11F5N4O/c17-13(18)8-23-14-11-4-3-9(16(19,20)21)6-12(11)25(15(26)24-14)10-2-1-5-22-7-10/h1-7,13H,8H2,(H,23,24,26)	DUPFXAUUUFPTFG-UHFFFAOYSA-N	507862	US11130759, Cpd. No. 325::US11046691, Compound 325::4-[(2,2-difluoroethyl)amino]-1-(pyridin- 3-yl)-7-(trifluoromethyl)hydro- quinazolin-2-one::US11084798, Cpd No 325	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507862&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147432376	459092946							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071869	O[C@@H]1CCN(C1)c1nc(=O)n(-c2cccnc2)c2cc(ccc12)C(F)(F)F |r|	InChI=1S/C18H15F3N4O2/c19-18(20,21)11-3-4-14-15(8-11)25(12-2-1-6-22-9-12)17(27)23-16(14)24-7-5-13(26)10-24/h1-4,6,8-9,13,26H,5,7,10H2	JMSHFADNDBTJQB-UHFFFAOYSA-N	507865	US11130759, Cpd. No. 326::US11046691, Compound 326::4-((3R)-3-hydroxypyrrolidinyl)-1- (pyridin-3-yl)-7-(trifluoromethyl)- hydroquinazolin-2-one::US11084798, Cpd No 326	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507865&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148084869	459092949							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071870	Nc1nc(=O)n(-c2cccnc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C14H9F3N4O/c15-14(16,17)8-3-4-10-11(6-8)21(13(22)20-12(10)18)9-2-1-5-19-7-9/h1-7H,(H2,18,20,22)	GWEFJDISPMOEHQ-UHFFFAOYSA-N	507868	US11130759, Cpd. No. 327::US11046691, Compound 327::4-amino-1-(pyridin-3-yl)-7-(trifluoro- methyl)hydroquinazolin-2-one::US11084798, Cpd No 327	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507868&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147718873	459092952							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071871	CNc1nc(=O)n(-c2ccc3[nH]ncc3c2)c2cc(Cl)ccc12	InChI=1S/C16H12ClN5O/c1-18-15-12-4-2-10(17)7-14(12)22(16(23)20-15)11-3-5-13-9(6-11)8-19-21-13/h2-8H,1H3,(H,19,21)(H,18,20,23)	WBCAASUDLZNZMM-UHFFFAOYSA-N	507871	US11130759, Cpd. No. 328::US11046691, Compound 328::1-(1H-indazol-5-yl)-7-chloro-4- (methyl-amino)hydroquinazolin-2-one::US11084798, Cpd No 328	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507871&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153154315	459092955							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071872	CNc1nc(=O)n(-c2ccccc2C)c2cc(Cl)cc(OC)c12 |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.39,;1.33,-.39,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.92,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.39,;-2.67,1.92,;-1.33,2.69,;-1.33,4.23,;-2.67,5,;,1.92,)|	InChI=1S/C17H16ClN3O2/c1-10-6-4-5-7-12(10)21-13-8-11(18)9-14(23-3)15(13)16(19-2)20-17(21)22/h4-9H,1-3H3,(H,19,20,22)	LGRSAKXOXYYRPR-UHFFFAOYSA-N	507874	US11130759, Cpd. No. 329::US11046691, Compound 329::7-chloro-5-methoxy-4-(methylamino)- 1-(2-methylphenyl)hydroquinazolin-2- one::US11084798, Cpd No 329	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507874&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148341190	459092958							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071873	COc1cc(ccc1F)-n1c2cc(Cl)ccc2c(O)nc1=O	InChI=1S/C15H10ClFN2O3/c1-22-13-7-9(3-5-11(13)17)19-12-6-8(16)2-4-10(12)14(20)18-15(19)21/h2-7H,1H3,(H,18,20,21)	ILADWDJZENHNPF-UHFFFAOYSA-N	507877	US11130759, Cpd. No. 330::US11046691, Compound 330::7-chloro-1-(4-fluoro-3- methoxyphenyl)-4- hydroxyhydroquinazolin-2-one::US11084798, Cpd No 330	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507877&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147937150	459092961							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071874	CNc1nc(=O)n(-c2cc(O)ccc2F)c2cc(Cl)ccc12 |(1.33,5.39,;1.33,3.85,;1.33,2.31,;2.67,1.54,;2.67,,;4,-.77,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,;4,-5.39,;1.33,-5.39,;,-4.62,;,-3.08,;-1.33,-2.31,;;-1.33,-.77,;-2.67,,;-4,-.77,;-2.67,1.54,;-1.33,2.31,;,1.54,)|	InChI=1S/C15H11ClFN3O2/c1-18-14-10-4-2-8(16)6-12(10)20(15(22)19-14)13-7-9(21)3-5-11(13)17/h2-7,21H,1H3,(H,18,19,22)	AYXYOASHIGCHPC-UHFFFAOYSA-N	507880	US11130759, Cpd. No. 331::US11046691, Compound 331::7-chloro-1-(6-fluoro-3-hydroxyphenyl)- 4-(methylamino)hydroquinazolin-2-one::US11084798, Cpd No 331	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507880&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147038181	459092964							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071875	COc1cccc(c1F)-n1c2cc(Cl)ccc2c(O)nc1=O |(4.67,-3.85,;3.33,-4.62,;2,-3.85,;.67,-4.62,;-.67,-3.85,;-.67,-2.31,;.67,-1.54,;2,-2.31,;3.33,-1.54,;.67,,;-.67,.77,;-2,,;-3.33,.77,;-4.67,,;-3.33,2.31,;-2,3.08,;-.67,2.31,;.67,3.08,;.67,4.62,;2,2.31,;2,.77,;3.33,,)|	InChI=1S/C15H10ClFN2O3/c1-22-12-4-2-3-10(13(12)17)19-11-7-8(16)5-6-9(11)14(20)18-15(19)21/h2-7H,1H3,(H,18,20,21)	GPIUHLIFCDANAW-UHFFFAOYSA-N	507883	US11130759, Cpd. No. 332::US11046691, Compound 332::7-chloro-1-(2-fluoro-3- metho xyphenyl)-4- hydroxyhydroquinazolin-2-one::US11084798, Cpd No 332	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507883&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514105	459092967							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071876	CNc1nc(=O)n(-c2cccc(O)c2F)c2cc(Cl)ccc12 |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.39,;1.33,-.39,;1.33,-1.93,;,-2.69,;,-4.23,;1.33,-5,;2.67,-4.23,;4,-5,;2.67,-2.69,;4,-1.92,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.39,;-2.67,1.92,;-1.33,2.69,;,1.92,)|	InChI=1S/C15H11ClFN3O2/c1-18-14-9-6-5-8(16)7-11(9)20(15(22)19-14)10-3-2-4-12(21)13(10)17/h2-7,21H,1H3,(H,18,19,22)	QYDDQMUVMAMUME-UHFFFAOYSA-N	507886	US11130759, Cpd. No. 333::US11046691, Compound 333::7-chloro-1-(2-fluoro-3-hydroxyphenyl)- 4-(methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 333	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507886&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608756	459092970							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071877	O[C@H]1C[C@@H](C1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.0,wD:3.5,(4.94,5.93,;3.61,5.16,;3.21,3.68,;1.72,4.08,;2.12,5.56,;.39,3.31,;.39,1.77,;1.72,1,;1.72,-.54,;3.06,-1.31,;.39,-1.31,;.39,-2.85,;-.94,-3.62,;-.94,-5.16,;.39,-5.93,;1.72,-5.16,;1.72,-3.62,;3.06,-2.85,;-.94,-.54,;-2.28,-1.31,;-3.61,-.54,;-3.61,1,;-2.28,1.77,;-.94,1,;-4.94,-1.31,;-6.28,-.54,;-4.94,-2.85,;-6.28,-2.08,)|	InChI=1S/C18H14ClF3N4O2/c19-12-3-1-2-4-13(12)26-16-11(5-6-14(24-16)18(20,21)22)15(25-17(26)28)23-9-7-10(27)8-9/h1-6,9-10,27H,7-8H2,(H,23,25,28)	FVEINZLDKQGZPA-UHFFFAOYSA-N	507889	US11130759, Cpd. No. 334::US11046691, Compound 334::1-(2-chlorophenyl)-4-(((1r,3r)-3- hydroxycyc1obutyl)amino)-7-(trifluoro- methyl)pyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 334	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507889&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608468	459092973							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071878	O[C@H]1CC[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:4.5,1.0,(-3.35,-2.82,;-4.12,-1.49,;-5.61,-1.09,;-5.21,.4,;-3.72,,;-2.39,.77,;-1.06,,;-1.06,-1.54,;.28,-2.31,;.28,-3.85,;1.61,-1.54,;2.94,-2.31,;4.28,-1.54,;5.61,-2.31,;5.61,-3.85,;4.28,-4.62,;2.94,-3.85,;1.61,-4.62,;1.61,,;2.94,.77,;2.94,2.31,;1.61,3.08,;.28,2.31,;.28,.77,;4.28,3.08,;5.61,2.31,;4.28,4.62,;5.61,3.85,)|	InChI=1S/C18H14ClF3N4O2/c19-10-3-1-2-4-12(10)26-16-9(5-8-14(24-16)18(20,21)22)15(25-17(26)28)23-11-6-7-13(11)27/h1-5,8,11,13,27H,6-7H2,(H,23,25,28)	SXNFVUHCVCEJLS-UHFFFAOYSA-N	507892	US11130759, Cpd. No. 336::US11046691, Compound 336::4-[((2S,1R)-2-hydroxycyclobutyl)- amino]-(1Sa)-(2-chlorophenyl)-7- (trifluoromethyl)hydro-pyrido[2,3-d]- pyrimidin-2(1H)-one::US11046691, Compound 335::US11084798, Cpd No 336	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507892&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608800	459092976							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071879	O[C@H]1CC[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:4.5,1.0,(-3.35,-2.82,;-4.12,-1.49,;-5.61,-1.09,;-5.21,.4,;-3.72,,;-2.39,.77,;-1.06,,;-1.06,-1.54,;.28,-2.31,;.28,-3.85,;1.61,-1.54,;2.94,-2.31,;4.28,-1.54,;5.61,-2.31,;5.61,-3.85,;4.28,-4.62,;2.94,-3.85,;1.61,-4.62,;1.61,,;2.94,.77,;2.94,2.31,;1.61,3.08,;.28,2.31,;.28,.77,;4.28,3.08,;5.61,2.31,;4.28,4.62,;5.61,3.85,)|	InChI=1S/C18H14ClF3N4O2/c19-10-3-1-2-4-12(10)26-16-9(5-8-14(24-16)18(20,21)22)15(25-17(26)28)23-11-6-7-13(11)27/h1-5,8,11,13,27H,6-7H2,(H,23,25,28)	SXNFVUHCVCEJLS-UHFFFAOYSA-N	507892	US11130759, Cpd. No. 336::US11046691, Compound 336::4-[((2S,1R)-2-hydroxycyclobutyl)- amino]-(1Sa)-(2-chlorophenyl)-7- (trifluoromethyl)hydro-pyrido[2,3-d]- pyrimidin-2(1H)-one::US11046691, Compound 335::US11084798, Cpd No 336	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507892&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608800	459092976							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071880	O[C@H]1CC[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.0,wD:4.5,(-3.35,-2.82,;-4.12,-1.49,;-5.61,-1.09,;-5.21,.4,;-3.72,,;-2.39,.77,;-1.06,,;-1.06,-1.54,;.28,-2.31,;.28,-3.85,;1.61,-1.54,;2.94,-2.31,;4.28,-1.54,;5.61,-2.31,;5.61,-3.85,;4.28,-4.62,;2.94,-3.85,;1.61,-4.62,;1.61,,;2.94,.77,;2.94,2.31,;1.61,3.08,;.28,2.31,;.28,.77,;4.28,3.08,;5.61,2.31,;4.28,4.62,;5.61,3.85,)|	InChI=1S/C18H14ClF3N4O2/c19-10-3-1-2-4-12(10)26-16-9(5-8-14(24-16)18(20,21)22)15(25-17(26)28)23-11-6-7-13(11)27/h1-5,8,11,13,27H,6-7H2,(H,23,25,28)	SXNFVUHCVCEJLS-UHFFFAOYSA-N	507898	US11130759, Cpd. No. 338::4-[((1S,2 S)-2-hydroxycyclobutyl)- amino]-(1Sa)-(2-chlorophenyl)-7- (trifluoromethyl)hydro-pyridino [2,3-d]- pyrimidin-2-one::US11046691, Compound 338::US11046691, Compound 337::US11084798, Cpd No 338	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507898&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608388	459092981							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071881	O[C@H]1CC[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.0,wD:4.5,(-3.35,-2.82,;-4.12,-1.49,;-5.61,-1.09,;-5.21,.4,;-3.72,,;-2.39,.77,;-1.06,,;-1.06,-1.54,;.28,-2.31,;.28,-3.85,;1.61,-1.54,;2.94,-2.31,;4.28,-1.54,;5.61,-2.31,;5.61,-3.85,;4.28,-4.62,;2.94,-3.85,;1.61,-4.62,;1.61,,;2.94,.77,;2.94,2.31,;1.61,3.08,;.28,2.31,;.28,.77,;4.28,3.08,;5.61,2.31,;4.28,4.62,;5.61,3.85,)|	InChI=1S/C18H14ClF3N4O2/c19-10-3-1-2-4-12(10)26-16-9(5-8-14(24-16)18(20,21)22)15(25-17(26)28)23-11-6-7-13(11)27/h1-5,8,11,13,27H,6-7H2,(H,23,25,28)	SXNFVUHCVCEJLS-UHFFFAOYSA-N	507898	US11130759, Cpd. No. 338::4-[((1S,2 S)-2-hydroxycyclobutyl)- amino]-(1Sa)-(2-chlorophenyl)-7- (trifluoromethyl)hydro-pyridino [2,3-d]- pyrimidin-2-one::US11046691, Compound 338::US11046691, Compound 337::US11084798, Cpd No 338	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507898&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608388	459092981							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071882	CN(C)c1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(,4.23,;1.33,3.46,;2.67,4.23,;1.33,1.92,;2.67,1.15,;2.67,-.39,;4,-1.16,;1.33,-1.16,;1.33,-2.7,;,-3.47,;,-5,;1.33,-5.78,;2.67,-5,;2.67,-3.47,;4,-2.69,;,-.39,;-1.33,-1.15,;-2.67,-.39,;-2.67,1.15,;-1.33,1.92,;,1.15,;-4,-1.16,;-5.33,-.39,;-4,-2.7,;-5.33,-1.93,)|	InChI=1S/C16H12ClF3N4O/c1-23(2)13-9-7-8-12(16(18,19)20)21-14(9)24(15(25)22-13)11-6-4-3-5-10(11)17/h3-8H,1-2H3	YDPSFAQJUWUEOL-UHFFFAOYSA-N	507904	US11130759, Cpd. No. 339::US11046691, Compound 339::4-(bis(methyl-d3)amino)-1-(2-chloro- phenyl)-7-(trifluoromethyl)-pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 244	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507904&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608851	459092986							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071883	Clc1ccc2c(c1)n(-c1ccc3[nH]cnc3c1)c(=O)[nH]c2=O	InChI=1S/C15H9ClN4O2/c16-8-1-3-10-13(5-8)20(15(22)19-14(10)21)9-2-4-11-12(6-9)18-7-17-11/h1-7H,(H,17,18)(H,19,21,22)	RELFEIOJLPHVTD-UHFFFAOYSA-N	507907	US11130759, Cpd. No. 340::US11046691, Compound 340::1-(1H-benzo[d]imidazol-5-yl)-7-chloro- quinazoline-2,4(1H,3H)-dione::US11084798, Cpd No 340	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507907&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370659	459092989							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071884	CNc1nc(=O)n(-c2cccnc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C15H11F3N4O/c1-19-13-11-5-4-9(15(16,17)18)7-12(11)22(14(23)21-13)10-3-2-6-20-8-10/h2-8H,1H3,(H,19,21,23)	YZRCUQNZGIZCKL-UHFFFAOYSA-N	507910	US11130759, Cpd. No. 341::US11046691, Compound 341::4-(methylamino)-1-(pyridin-3-yl)-7- (trifluoromethyl)hydroquinazolin-2-one::US11084798, Cpd No 341	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507910&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608336	459092992							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071885	CNc1nc(=O)n(-c2ccccc2Cl)c2c(Cl)c(ccc12)C(F)(F)F |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;,-2.69,;,-4.23,;1.33,-5,;2.67,-4.23,;2.67,-2.69,;4,-1.93,;,.38,;-1.33,-.38,;-1.33,-1.93,;-2.67,.38,;-2.67,1.93,;-1.33,2.69,;,1.93,;-4,-.38,;-5.33,.39,;-4,-1.92,;-5.33,-1.15,)|	InChI=1S/C16H10Cl2F3N3O/c1-22-14-8-6-7-9(16(19,20)21)12(18)13(8)24(15(25)23-14)11-5-3-2-4-10(11)17/h2-7H,1H3,(H,22,23,25)	MIHAPYYSWXGNPA-UHFFFAOYSA-N	507913	US11130759, Cpd. No. 342::US11046691, Compound 342::8-chloro-1-(2-chlorophenyl)-4- (methylamino)-7-(trifluoromethyl)- hydroquinazolin-2-one::US11084798, Cpd No 342	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507913&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608589	459092995							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071886	CNc1nc(=O)n(-c2ccccc2)c2c(Cl)c(ccc12)C(F)(F)F	InChI=1S/C16H11ClF3N3O/c1-21-14-10-7-8-11(16(18,19)20)12(17)13(10)23(15(24)22-14)9-5-3-2-4-6-9/h2-8H,1H3,(H,21,22,24)	HOCWIXIOPLYQLI-UHFFFAOYSA-N	507916	US11130759, Cpd. No. 343::US11046691, Compound 343::8-chloro-4-(methylamino)-1-phenyl-7- (trifluoromethyl)hydroquinazolin-2-one::US11084798, Cpd No 343	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507916&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608987	459092998							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071887	C[C@@H]1CCCN1c1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F |r|	InChI=1S/C19H17F3N4O/c1-12-6-5-11-25(12)16-14-9-10-15(19(20,21)22)23-17(14)26(18(27)24-16)13-7-3-2-4-8-13/h2-4,7-10,12H,5-6,11H2,1H3	JMILKIBIMHZPCZ-UHFFFAOYSA-N	507919	US11130759, Cpd. No. 344::US11046691, Compound 344::4-((2R)-2-methylpyrrolidin-1-yl)-1- phenyl-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 344	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507919&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608413	459093001							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071888	C[C@H]1CCCN1c1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F |r|	InChI=1S/C19H17F3N4O/c1-12-6-5-11-25(12)16-14-9-10-15(19(20,21)22)23-17(14)26(18(27)24-16)13-7-3-2-4-8-13/h2-4,7-10,12H,5-6,11H2,1H3	JMILKIBIMHZPCZ-UHFFFAOYSA-N	507922	US11046691, Compound 345::4-((2S)-2-methylpyrrolidin-1-yl)-1- phenyl-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 345	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507922&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608667	459093004							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071889	FC(F)(F)c1ccc2c(nc(=O)n(-c3ccccc3)c2n1)N1CCSC1	InChI=1S/C17H13F3N4OS/c18-17(19,20)13-7-6-12-14(23-8-9-26-10-23)22-16(25)24(15(12)21-13)11-4-2-1-3-5-11/h1-7H,8-10H2	GBCNLUQDPMHLJC-UHFFFAOYSA-N	507925	US11130759, Cpd. No. 346::US11046691, Compound 346::1-phenyl-4-(1,3-thiazolidin-3-yl)-7- (trifluoromethyl) pyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 346	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507925&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514065	459093007							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071890	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(Cl)ccc12 |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.39,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.92,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-2.67,1.93,;-1.33,2.69,;,1.92,)|	InChI=1S/C15H11Cl2N3O/c1-18-14-10-7-6-9(16)8-13(10)20(15(21)19-14)12-5-3-2-4-11(12)17/h2-8H,1H3,(H,18,19,21)	WLCVLMQIELQLLD-UHFFFAOYSA-N	507864	US11130759, Cpd. No. 347::US11046691, Compound 218::7-chloro-1-(2-chlorophenyl)-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 218	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507864&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152279906	459092948							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071891	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(OCC3CC3)c12	InChI=1S/C19H18ClN3O2/c1-21-18-17-15(9-13(20)10-16(17)25-11-12-7-8-12)23(19(24)22-18)14-5-3-2-4-6-14/h2-6,9-10,12H,7-8,11H2,1H3,(H,21,22,24)	CCHLJPBAAKBWJO-UHFFFAOYSA-N	507931	US11130759, Cpd. No. 348::US11046691, Compound 348::7-chloro-5-(cyclopropylmethoxy)-4- (methylamino)-1-phenylhydro- quinazolin-2-one::US11084798, Cpd No 348	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507931&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514024	459093013							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071892	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(OC(C)C)c12	InChI=1S/C18H18ClN3O2/c1-11(2)24-15-10-12(19)9-14-16(15)17(20-3)21-18(23)22(14)13-7-5-4-6-8-13/h4-11H,1-3H3,(H,20,21,23)	WOSMAAQMYZSLRH-UHFFFAOYSA-N	507934	US11130759, Cpd. No. 349::US11046691, Compound 349::7-chloro-4-(methylamino)-5-(methyl- ethoxy)-1-phenylhydroquinazolin-2-one::US11084798, Cpd No 349	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507934&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153226581	459093016							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071893	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(OCC(F)(F)F)c12	InChI=1S/C17H13ClF3N3O2/c1-22-15-14-12(7-10(18)8-13(14)26-9-17(19,20)21)24(16(25)23-15)11-5-3-2-4-6-11/h2-8H,9H2,1H3,(H,22,23,25)	QUTNFGMNTRAWTC-UHFFFAOYSA-N	507937	US11130759, Cpd. No. 350::US11046691, Compound 350::7-chloro-4-(methylamino)-1-phenyl-5- (2,2,2-trifluoroethoxy)hydroquinazolin- 2-one::US11084798, Cpd No 350	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507937&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514050	459093019							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071894	CNc1nc(=O)n(-c2ccccc2Br)c2cc(ccc12)C1CC1 |(.77,5,;2.1,4.23,;2.1,2.69,;3.44,1.93,;3.44,.38,;4.77,-.38,;2.1,-.38,;2.1,-1.93,;3.44,-2.69,;3.44,-4.23,;2.1,-5,;.77,-4.23,;.77,-2.69,;-.56,-1.93,;.77,.38,;-.56,-.38,;-1.9,.38,;-1.9,1.93,;-.56,2.69,;.77,1.93,;-3.23,-.38,;-4.77,-.38,;-4,-1.72,)|	InChI=1S/C18H16BrN3O/c1-20-17-13-9-8-12(11-6-7-11)10-16(13)22(18(23)21-17)15-5-3-2-4-14(15)19/h2-5,8-11H,6-7H2,1H3,(H,20,21,23)	CASGOCXGOIAVHT-UHFFFAOYSA-N	507940	US11130759, Cpd. No. 719::US11046691, Compound 351::1-(2-bromophenyl)-7-cyclopropyl-4- (methylamino)hydroquinazolin-2-one::US11084798, Cpd No 719	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507940&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147187176	459093022							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071895	CNc1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C1CC1 |(.77,5,;2.1,4.23,;2.1,2.69,;3.44,1.93,;3.44,.38,;4.77,-.38,;2.1,-.38,;2.1,-1.93,;3.44,-2.69,;3.44,-4.23,;2.1,-5,;.77,-4.23,;.77,-2.69,;-.56,-1.93,;.77,.38,;-.56,-.38,;-1.9,.38,;-1.9,1.93,;-.56,2.69,;.77,1.93,;-3.23,-.38,;-4.77,-.38,;-4,-1.72,)|	InChI=1S/C19H19N3O/c1-12-5-3-4-6-16(12)22-17-11-14(13-7-8-13)9-10-15(17)18(20-2)21-19(22)23/h3-6,9-11,13H,7-8H2,1-2H3,(H,20,21,23)	XFNVSMDZJZKDCN-UHFFFAOYSA-N	507943	US11130759, Cpd. No. 352::US11046691, Compound 352::7-cyclopropyl-4-(methylamino)-1-(2- methylphenyl)hydroquinazolin-2-one::US11084798, Cpd No 352	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507943&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149205598	459093025							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071896	CNc1nc(=O)n(-c2cccc(c2)C2CC2)c2cc(Cl)ccc12	InChI=1S/C18H16ClN3O/c1-20-17-15-8-7-13(19)10-16(15)22(18(23)21-17)14-4-2-3-12(9-14)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,20,21,23)	PHXKTOVNUQRPDI-UHFFFAOYSA-N	507946	US11130759, Cpd. No. 353::US11046691, Compound 353::7-chloro-1-(3-cyclopropylphenyl)-4- (methylamino)hydroquinazolin-2-one::US11084798, Cpd No 353	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507946&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514213	459093028							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071897	FC(F)c1cccc(c1)-n1c2cc(Cl)ccc2c(=O)[nH]c1=O	InChI=1S/C15H9ClF2N2O2/c16-9-4-5-11-12(7-9)20(15(22)19-14(11)21)10-3-1-2-8(6-10)13(17)18/h1-7,13H,(H,19,21,22)	URRMCFLBYJRWAH-UHFFFAOYSA-N	507949	US11130759, Cpd. No. 354::US11046691, Compound 354::7-chloro-1-(3-difluoromethylphenyl)- quinazoline-2,4(1H,3H)-dione::US11084798, Cpd No 354	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507949&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370661	459093031							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071898	CNc1nc(=O)n(-c2cccc(c2)C(F)F)c2cc(Cl)ccc12	InChI=1S/C16H12ClF2N3O/c1-20-15-12-6-5-10(17)8-13(12)22(16(23)21-15)11-4-2-3-9(7-11)14(18)19/h2-8,14H,1H3,(H,20,21,23)	JCNFXTBEOWJREX-UHFFFAOYSA-N	507952	US11130759, Cpd. No. 355::US11046691, Compound 355::7-chloro-1-(3-(difluoromethyl)phenyl)- 4-(methylamino)-3,4- dihydroquinazolin-2(1H)-one::US11084798, Cpd No 355	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507952&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608210	459093034							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071899	FC(F)(F)c1cccc(c1)-n1c2cc(Cl)ccc2c(=O)[nH]c1=O	InChI=1S/C15H8ClF3N2O2/c16-9-4-5-11-12(7-9)21(14(23)20-13(11)22)10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,20,22,23)	LYPVWPKZHQIGHX-UHFFFAOYSA-N	507955	US11130759, Cpd. No. 356::US11046691, Compound 356::7-chloro-1-(3-trifluoromethylphenyl)- quinazoline-2,4(1H,3H)-dione::US11084798, Cpd No 356	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507955&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			85587301	459093037							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071900	Oc1nc(=O)n(-c2ccc3[nH]ncc3c2)c2cc(Cl)ccc12	InChI=1S/C15H9ClN4O2/c16-9-1-3-11-13(6-9)20(15(22)18-14(11)21)10-2-4-12-8(5-10)7-17-19-12/h1-7H,(H,17,19)(H,18,21,22)	MXMZHSVTAAGGFH-UHFFFAOYSA-N	507958	US11130759, Cpd. No. 357::US11046691, Compound 357::1-(1H-indazol-5-yl)-7-chloro-4- hydroxy-hydroquinazolin-2-one::US11084798, Cpd No 357	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507958&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514053	459093040							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071901	FC(F)(F)c1ccc2c(n1)n(-c1cnccc1Cl)c(=O)[nH]c2=O |(-5.38,.54,;-4.03,-.19,;-3.97,-1.72,;-5.33,-1,;-2.72,.63,;-2.77,2.17,;-1.47,2.98,;-.11,2.26,;-.05,.72,;-1.36,-.09,;1.31,,;1.36,-1.54,;.05,-2.36,;.11,-3.89,;1.47,-4.62,;2.77,-3.8,;2.72,-2.26,;4.03,-1.45,;2.61,.82,;3.97,.09,;2.56,2.36,;1.2,3.08,;1.14,4.62,)|	InChI=1S/C13H6ClF3N4O2/c14-7-3-4-18-5-8(7)21-10-6(11(22)20-12(21)23)1-2-9(19-10)13(15,16)17/h1-5H,(H,20,22,23)	VKJXNAMUJHRSNE-UHFFFAOYSA-N	507961	US11130759, Cpd. No. 358::US11046691, Compound 358::1-(4-chloropyridin-3-yl)-7-(trifluoro- methyl)pyrido[2,3-d]pyrimidine- 2,4(1H,3H)-dione::US11084798, Cpd No 358	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507961&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370662	459093043							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071902	FC(F)(F)c1ccc2c(n1)n(-c1cccnc1)c(=O)[nH]c2=O	InChI=1S/C13H7F3N4O2/c14-13(15,16)9-4-3-8-10(18-9)20(12(22)19-11(8)21)7-2-1-5-17-6-7/h1-6H,(H,19,21,22)	DZNUWQGJTLFBTA-UHFFFAOYSA-N	507964	US11130759, Cpd. No. 359::US11046691, Compound 359::1-(pyridin-3-yl)-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidine-2,4(1H,3H)- dione::US11084798, Cpd No 359	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507964&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370663	459093046							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071903	FC(F)(F)c1ccc2c(c1Cl)n(-c1ccccc1Cl)c(=O)[nH]c2=O |(-5.33,.77,;-4,,;-4,-1.54,;-5.33,-.77,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;,.77,;-1.33,,;-1.33,-1.54,;1.33,,;1.33,-1.54,;,-2.31,;,-3.85,;1.33,-4.62,;2.67,-3.85,;2.67,-2.31,;4,-1.54,;2.67,.77,;4,,;2.67,2.31,;1.33,3.08,;1.33,4.62,)|	InChI=1S/C15H7Cl2F3N2O2/c16-9-3-1-2-4-10(9)22-12-7(13(23)21-14(22)24)5-6-8(11(12)17)15(18,19)20/h1-6H,(H,21,23,24)	AZVFSUARIZRJCB-UHFFFAOYSA-N	507967	US11130759, Cpd. No. 360::US11046691, Compound 360::8-chloro-1-(2-chlorophenyl)-7- (trifluoro-methyl)pyrido[2,3- d]pyrimidine-2,4(1H,3H)-dione-1::US11084798, Cpd No 360	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507967&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370664	459093049							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071904	FC(F)(F)c1ccc2c(c1Cl)n(-c1ccccc1)c(=O)[nH]c2=O	InChI=1S/C15H8ClF3N2O2/c16-11-10(15(17,18)19)7-6-9-12(11)21(14(23)20-13(9)22)8-4-2-1-3-5-8/h1-7H,(H,20,22,23)	TXFSYEAIEYLYJO-UHFFFAOYSA-N	507970	US11130759, Cpd. No. 361::US11046691, Compound 361::8-chloro-1-phenyl-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidine-2,4(1H,3H)- dione::US11084798, Cpd No 361	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507970&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370666	459093052							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071905	FC(F)(F)c1ccc2c(c1)n(-c1cccnc1)c(=O)[nH]c2=O	InChI=1S/C14H8F3N3O2/c15-14(16,17)8-3-4-10-11(6-8)20(13(22)19-12(10)21)9-2-1-5-18-7-9/h1-7H,(H,19,21,22)	XWXKYOCQYBLBSX-UHFFFAOYSA-N	507973	US11130759, Cpd. No. 362::US11046691, Compound 362::1-(pyridin-3-yl)-7-(trifluoromethyl)-1,3- dihydroquinazoline-2,4-dione::US11084798, Cpd No 362	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507973&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370668	459093055							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071906	FC(F)(F)c1ccc2c(n1)n(-c1cccc3ncsc13)c(=O)[nH]c2=O |(-5.85,.77,;-4.52,,;-4.52,-1.54,;-5.85,-.77,;-3.19,.77,;-3.19,2.31,;-1.85,3.08,;-.52,2.31,;-.52,.77,;-1.85,,;.82,,;.82,-1.54,;-.52,-2.31,;-.52,-3.85,;.82,-4.62,;2.15,-3.85,;3.61,-4.33,;4.52,-3.08,;3.61,-1.83,;2.15,-2.31,;2.15,.77,;3.48,,;2.15,2.31,;.82,3.08,;.82,4.62,)|	InChI=1S/C15H7F3N4O2S/c16-15(17,18)10-5-4-7-12(20-10)22(14(24)21-13(7)23)9-3-1-2-8-11(9)25-6-19-8/h1-6H,(H,21,23,24)	CUDYBJMROIEJPA-UHFFFAOYSA-N	507976	US11130759, Cpd. No. 363::US11046691, Compound 363::1-benzothiazol-7-yl-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidine-2,4(1H,3H)- dione::US11084798, Cpd No 363	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507976&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370669	459093058							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071907	Cc1ncccc1-n1c2nc(ccc2c(=O)[nH]c1=O)C(F)(F)F |(3.97,-1.59,;2.63,-2.33,;2.6,-3.87,;1.25,-4.62,;-.07,-3.83,;-.04,-2.29,;1.31,-1.54,;1.33,,;.01,.79,;-1.33,.05,;-2.65,.84,;-2.63,2.38,;-1.28,3.13,;.04,2.33,;1.39,3.08,;1.41,4.62,;2.71,2.29,;2.68,.75,;4,-.05,;-4,.09,;-5.32,.89,;-4.03,-1.45,;-5.35,-.65,)|	InChI=1S/C14H9F3N4O2/c1-7-9(3-2-6-18-7)21-11-8(12(22)20-13(21)23)4-5-10(19-11)14(15,16)17/h2-6H,1H3,(H,20,22,23)	XZTTYJUBPZVOAK-UHFFFAOYSA-N	507979	US11130759, Cpd. No. 364::US11046691, Compound 364::1-(2-methylpyridin-3-yl)-7-(trifluoro- methyl)pyrido[2,3-d]pyrimidine- 2,4(1H,3H)-dione::US11084798, Cpd No 364	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507979&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370671	459093061							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071908	Cc1ccncc1-n1c2nc(ccc2c(=O)[nH]c1=O)C(F)(F)F |(4.03,-1.45,;2.72,-2.26,;2.77,-3.8,;1.47,-4.62,;.11,-3.89,;.05,-2.36,;1.36,-1.54,;1.31,,;-.05,.72,;-1.36,-.09,;-2.72,.63,;-2.77,2.17,;-1.47,2.98,;-.11,2.26,;1.2,3.08,;1.14,4.62,;2.56,2.36,;2.61,.82,;3.97,.09,;-4.03,-.19,;-5.38,.54,;-3.97,-1.72,;-5.33,-1,)|	InChI=1S/C14H9F3N4O2/c1-7-4-5-18-6-9(7)21-11-8(12(22)20-13(21)23)2-3-10(19-11)14(15,16)17/h2-6H,1H3,(H,20,22,23)	FINZGEATRUSGJG-UHFFFAOYSA-N	507982	US11130759, Cpd. No. 365::US11046691, Compound 365::1-(4-methylpyridin-3-yl)-7-(trifluoro- methyl)pyrido[2,3-d]pyrimidine- 2,4(1H,3H)-dione::US11084798, Cpd No 365	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507982	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507982&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370672	459093064							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071909	CNc1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F	InChI=1S/C15H11F3N4O/c1-19-12-10-7-8-11(15(16,17)18)20-13(10)22(14(23)21-12)9-5-3-2-4-6-9/h2-8H,1H3,(H,19,21,23)	NSPRCNZXZORNPC-UHFFFAOYSA-N	507985	US11130759, Cpd. No. 366::4-((methyl-d3)amino)-1-phenyl-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11046691, Compound 184::US11046691, Compound 366::US11084798, Cpd No 184	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507985&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148686497	459093067							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071910	CNc1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.93,;,.38,;-1.33,-.38,;-2.67,.38,;-2.67,1.93,;-1.33,2.69,;,1.93,;-4,-.38,;-5.33,.39,;-4,-1.92,;-5.33,-1.15,)|	InChI=1S/C17H14F3N3O/c1-10-5-3-4-6-13(10)23-14-9-11(17(18,19)20)7-8-12(14)15(21-2)22-16(23)24/h3-9H,1-2H3,(H,21,22,24)	AMHMREQJMOJQHY-UHFFFAOYSA-N	507926	US11130759, Cpd. No. 367::US11046691, Compound 129::4-(methylamino)-1-(2-methylphenyl)-7- (trifluoromethyl)hydroquinazolin-2-one::US11084798, Cpd No 129	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507926&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			146970364	459093008							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071911	CNc1nc(=O)n(-c2ccccc2Br)c2cc(Cl)ccc12 |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.93,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-2.67,1.93,;-1.33,2.69,;,1.93,)|	InChI=1S/C15H11BrClN3O/c1-18-14-10-7-6-9(17)8-13(10)20(15(21)19-14)12-5-3-2-4-11(12)16/h2-8H,1H3,(H,18,19,21)	ZQJJGFPAOXBOAP-UHFFFAOYSA-N	507885	US11130759, Cpd. No. 368::US11046691, Compound 225::1-(2-bromophenyl)-7-chloro-4- (methylamino)quinazolin-2-one::US11084798, Cpd No 225	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507885&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608655	459092969							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071912	CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C16H12F3N3O/c1-20-14-12-8-7-10(16(17,18)19)9-13(12)22(15(23)21-14)11-5-3-2-4-6-11/h2-9H,1H3,(H,20,21,23)	GEKDQWJWACUGHU-UHFFFAOYSA-N	507753	US11130759, Cpd. No. 51::4-(methylamino)-1-phenyl-7-(trifluoro- methyl)-quinazolin-2(1H)-one::US11046691, Compound 369::US11046691, Compound 51::US11084798, Cpd No 51	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507753&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150275149	459092838							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071913	CNc1nc(=O)n(-c2ncccc2Cl)c2cc(Cl)ccc12 |(,5,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.39,;1.33,-.39,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.92,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.39,;-2.67,1.92,;-1.33,2.69,;,1.92,)|	InChI=1S/C14H10Cl2N4O/c1-17-12-9-5-4-8(15)7-11(9)20(14(21)19-12)13-10(16)3-2-6-18-13/h2-7H,1H3,(H,17,19,21)	AUNFMAPOYSPASM-UHFFFAOYSA-N	507996	US11130759, Cpd. No. 370::US11046691, Compound 370::7-chloro-1-(3-chloro(2-pyridyl))-4- (methylamino)hydroquinazolin-2-one::US11084798, Cpd No 370	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507996&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608554	459093076							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071914	CNc1nc(=O)n(-c2ncccc2C)c2cc(Cl)ccc12 |(-.06,4.95,;1.33,4.29,;1.33,2.75,;2.67,1.98,;2.67,.44,;4,-.33,;1.33,-.33,;1.33,-1.87,;2.67,-2.64,;2.67,-4.18,;1.33,-4.95,;,-4.18,;,-2.64,;-1.33,-1.87,;,.44,;-1.33,-.33,;-2.67,.44,;-4,-.33,;-2.67,1.98,;-1.33,2.75,;,1.98,)|	InChI=1S/C15H13ClN4O/c1-9-4-3-7-18-14(9)20-12-8-10(16)5-6-11(12)13(17-2)19-15(20)21/h3-8H,1-2H3,(H,17,19,21)	FFZSRQRYISZUQO-UHFFFAOYSA-N	507999	US11130759, Cpd. No. 371::US11046691, Compound 371::7-chloro-1-(3-methylpyridin-2-yl))-4- (methylamino)hydroquinazolin-2-one::US11084798, Cpd No 371	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507999&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608354	459093079							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071915	OC1CN(C1)c1nc(=O)n(-c2ccccc2)c2cc(ccc12)C1CC1	InChI=1S/C20H19N3O2/c24-16-11-22(12-16)19-17-9-8-14(13-6-7-13)10-18(17)23(20(25)21-19)15-4-2-1-3-5-15/h1-5,8-10,13,16,24H,6-7,11-12H2	RITRKDLZCICJSL-UHFFFAOYSA-N	508002	US11130759, Cpd. No. 372::US11046691, Compound 372::7-cyclopropyl-4-(3-hydroxyazetidin-1- yl)-1-phenylhydroquinazolin-2-one::US11084798, Cpd No 372	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508002&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608605	459093082							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071916	FC(F)CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C1CC1	InChI=1S/C19H17F2N3O/c20-17(21)11-22-18-15-9-8-13(12-6-7-12)10-16(15)24(19(25)23-18)14-4-2-1-3-5-14/h1-5,8-10,12,17H,6-7,11H2,(H,22,23,25)	ZUSHOXGYGHOCOQ-UHFFFAOYSA-N	508005	US11130759, Cpd. No. 373::US11046691, Compound 373::7-cyclopropyl-4((2-fluoropropyl)- amino)-1-phenylquinazolin-2(1H)-one::US11084798, Cpd No 373	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508005&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152716491	459093085							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071917	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(ccc12)C1CC1 |r|	InChI=1S/C21H21N3O2/c25-17-10-11-23(13-17)20-18-9-8-15(14-6-7-14)12-19(18)24(21(26)22-20)16-4-2-1-3-5-16/h1-5,8-9,12,14,17,25H,6-7,10-11,13H2	FMZUQYLRTCTPDN-UHFFFAOYSA-N	508008	US11130759, Cpd. No. 374::US11046691, Compound 374::4-((3R)-3-hydroxypyrrolidinyl)-7- cyclopropyl-1-phenylhydroquazolin- 2-one::US11084798, Cpd No 374	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508008&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933513	459093088							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071918	Cc1ccccc1-n1c2cc(ccc2c(=O)[nH]c1=O)C1CC1 |(-.56,-1.54,;.77,-2.31,;.77,-3.85,;2.1,-4.62,;3.44,-3.85,;3.44,-2.31,;2.1,-1.54,;2.1,,;.77,.77,;-.56,,;-1.9,.77,;-1.9,2.31,;-.56,3.08,;.77,2.31,;2.1,3.08,;2.1,4.62,;3.44,2.31,;3.44,.77,;4.77,,;-3.23,,;-4.77,,;-4,-1.33,)|	InChI=1S/C18H16N2O2/c1-11-4-2-3-5-15(11)20-16-10-13(12-6-7-12)8-9-14(16)17(21)19-18(20)22/h2-5,8-10,12H,6-7H2,1H3,(H,19,21,22)	YDYFPGOFPSPZOS-UHFFFAOYSA-N	508011	US11130759, Cpd. No. 375::US11046691, Compound 375::7-cyclopropyl-1-(o-tolyl)quinazoline- 2,4(1H,3H)-dione::US11084798, Cpd No 375	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508011&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370674	459093091							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071919	CNc1nc(=O)n(-c2cnccc2C)c2nc(ccc12)C(F)(F)F |(2.67,5.01,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.39,;1.33,-.39,;1.33,-1.93,;,-2.7,;,-4.24,;1.33,-5.01,;2.67,-4.24,;2.67,-2.7,;4,-1.92,;,.38,;-1.33,-.39,;-2.67,.38,;-2.67,1.92,;-1.33,2.69,;,1.92,;-4,-.39,;-5.33,.38,;-4,-1.93,;-5.33,-1.16,)|	InChI=1S/C15H12F3N5O/c1-8-5-6-20-7-10(8)23-13-9(12(19-2)22-14(23)24)3-4-11(21-13)15(16,17)18/h3-7H,1-2H3,(H,19,22,24)	WIXMQTWHZLUFJV-UHFFFAOYSA-N	508014	US11130759, Cpd. No. 376::US11046691, Compound 376::4-(methylamino)-1-(4-methylpyridin-3- yl)-7-(trifluoromethyppyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 376	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508014&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608533	459093094							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071920	CNc1nc(=O)n(-c2cnccc2Cl)c2nc(ccc12)C(F)(F)F |(3.13,4.93,;1.73,4.28,;1.6,2.74,;2.86,1.86,;2.72,.33,;3.99,-.56,;1.33,-.33,;1.19,-1.86,;-.2,-2.51,;-.34,-4.04,;.93,-4.93,;2.32,-4.28,;2.46,-2.74,;3.85,-2.09,;.07,.56,;-1.33,-.09,;-2.59,.79,;-2.46,2.32,;-1.06,2.98,;.2,2.09,;-3.99,.14,;-5.25,1.02,;-4.12,-1.39,;-5.38,-.51,)|	InChI=1S/C14H9ClF3N5O/c1-19-11-7-2-3-10(14(16,17)18)21-12(7)23(13(24)22-11)9-6-20-5-4-8(9)15/h2-6H,1H3,(H,19,22,24)	MREPBFPKPKRUQW-UHFFFAOYSA-N	508017	US11130759, Cpd. No. 377::US11046691, Compound 377::1-(4-chloropyridin-3-yl)-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 377	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508017&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608487	459093097							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071921	CNc1nc(=O)n(-c2cccnc2)c2nc(ccc12)C(F)(F)F	InChI=1S/C14H10F3N5O/c1-18-11-9-4-5-10(14(15,16)17)20-12(9)22(13(23)21-11)8-3-2-6-19-7-8/h2-7H,1H3,(H,18,21,23)	HURMURPRVPGGFA-UHFFFAOYSA-N	508020	US11130759, Cpd. No. 378::US11046691, Compound 378::4-(methylamino)-1-(pyridin-3-yl)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 378	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508020&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608946	459093100							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071922	CNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(2.82,4.19,;1.45,3.5,;1.37,1.96,;2.66,1.12,;2.58,-.42,;3.87,-1.26,;1.21,-1.12,;1.13,-2.66,;-.24,-3.36,;-.32,-4.89,;.97,-5.73,;2.34,-5.03,;2.42,-3.5,;3.79,-2.8,;-.08,-.28,;-1.45,-.98,;-2.74,-.14,;-2.66,1.4,;-1.29,2.1,;,1.26,;-4.12,-.84,;-5.41,-0,;-4.2,-2.38,;-5.49,-1.54,)|	InChI=1S/C15H10ClF3N4O/c1-20-12-8-6-7-11(15(17,18)19)21-13(8)23(14(24)22-12)10-5-3-2-4-9(10)16/h2-7H,1H3,(H,20,22,24)	DRPUHIIWNZBMQN-UHFFFAOYSA-N	508023	US11130759, Cpd. No. 379::US11046691, Compound 379::1-(2-chlorophenyl)-4-((methyl-d3)- amino)-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 178	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508023&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147416416	459093103							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071923	CNc1nc(=O)n(-c2cccnc2C)c2nc(ccc12)C(F)(F)F |(2.67,5.01,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.39,;1.33,-.39,;1.33,-1.93,;2.67,-2.7,;2.67,-4.24,;1.33,-5.01,;,-4.24,;,-2.7,;-1.33,-1.93,;,.38,;-1.33,-.39,;-2.67,.38,;-2.67,1.92,;-1.33,2.69,;,1.92,;-4,-.39,;-5.33,.38,;-4,-1.93,;-5.33,-1.16,)|	InChI=1S/C15H12F3N5O/c1-8-10(4-3-7-20-8)23-13-9(12(19-2)22-14(23)24)5-6-11(21-13)15(16,17)18/h3-7H,1-2H3,(H,19,22,24)	LKUHMOBCXVGSAX-UHFFFAOYSA-N	508026	US11130759, Cpd. No. 380::US11046691, Compound 380::4-(methylamino)-1-(2-methylpyridin-3- yl)-7-(trifluoromethyl)pyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 380	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508026&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608584	459093106							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071924	CNc1nc(=O)n(-c2cccc3ncsc23)c2nc(ccc12)C(F)(F)F |(1.54,5.04,;.28,4.16,;.41,2.63,;1.81,1.98,;1.94,.44,;3.34,-.21,;.68,-.44,;.81,-1.98,;-.45,-2.86,;-.31,-4.39,;1.08,-5.04,;2.34,-4.16,;3.84,-4.51,;4.64,-3.19,;3.63,-2.02,;2.21,-2.63,;-.72,.21,;-1.98,-.67,;-3.37,-.02,;-3.51,1.51,;-2.25,2.39,;-.85,1.74,;-4.64,-.91,;-6.03,-.26,;-4.5,-2.44,;-5.9,-1.79,)|	InChI=1S/C16H10F3N5OS/c1-20-13-8-5-6-11(16(17,18)19)22-14(8)24(15(25)23-13)10-4-2-3-9-12(10)26-7-21-9/h2-7H,1H3,(H,20,23,25)	YZKPKIUBIHEISX-UHFFFAOYSA-N	508029	US11130759, Cpd. No. 381::US11046691, Compound 381::1-benzothiazol-7-yl-4-(methylamino)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 381	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508029&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608458	459093109							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071925	CCC(C)c1ccc2c(NC)nc(=O)n(-c3ccccc3)c2c1 |w:2.2|	InChI=1S/C19H21N3O/c1-4-13(2)14-10-11-16-17(12-14)22(15-8-6-5-7-9-15)19(23)21-18(16)20-3/h5-13H,4H2,1-3H3,(H,20,21,23)	KUDZNQZCBXPJME-UHFFFAOYSA-N	508033	US11130759, Cpd. No. 382::US11046691, Compound 382::4-(methylamino)-7-(methylpropyl)-1- phenylhydroquinazolin-2-one::US11084798, Cpd No 382	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508033&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609031	459093113							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071926	Nc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(Cl)c12	InChI=1S/C14H9Cl2N3O/c15-8-6-10(16)12-11(7-8)19(14(20)18-13(12)17)9-4-2-1-3-5-9/h1-7H,(H2,17,18,20)	XPCRNHUHSRRYOZ-UHFFFAOYSA-N	508036	US11130759, Cpd. No. 383::US11046691, Compound 383::4-amino-5,7-dichloro-1-phenyl- hydroquinazolin-2-one::US11084798, Cpd No 383	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508036&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609066	459093116							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071927	Cc1ccc2c(nc(=O)n(-c3ccccc3)c2n1)N1CC(O)C1	InChI=1S/C17H16N4O2/c1-11-7-8-14-15(20-9-13(22)10-20)19-17(23)21(16(14)18-11)12-5-3-2-4-6-12/h2-8,13,22H,9-10H2,1H3	KJCYZPNAKXBQCY-UHFFFAOYSA-N	508039	US11130759, Cpd. No. 384::US11046691, Compound 384::4-(3-hydroxyazetidin-1-yl)-7-methyl-1- phenylpyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 384	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508039&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608265	459093119							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071928	FC(F)(F)CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C1CC1	InChI=1S/C19H16F3N3O/c20-19(21,22)11-23-17-15-9-8-13(12-6-7-12)10-16(15)25(18(26)24-17)14-4-2-1-3-5-14/h1-5,8-10,12H,6-7,11H2,(H,23,24,26)	KMKMISRYPWEUKE-UHFFFAOYSA-N	508042	US11130759, Cpd. No. 385::US11046691, Compound 385::7-cyclopropyl-1-phenyl-4-[(2,2,2- trifluoroethyl)amino]hydroquinazolin- 2-one::US11084798, Cpd No 385	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508042&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608560	459093122							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071929	O=c1nc(N2CCCC2)c2ccc(cc2n1-c1ccccc1)C1CC1	InChI=1S/C21H21N3O/c25-21-22-20(23-12-4-5-13-23)18-11-10-16(15-8-9-15)14-19(18)24(21)17-6-2-1-3-7-17/h1-3,6-7,10-11,14-15H,4-5,8-9,12-13H2	HPBFTYBOQZSTAM-UHFFFAOYSA-N	508045	US11130759, Cpd. No. 386::US11046691, Compound 386::7-cyclopropyl-1-phenyl-4-pyrrolidin-1- ylhydroquinazolin-2-one::US11084798, Cpd No 386	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508045&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608545	459093125							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071930	Nc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(-n3cccn3)c12	InChI=1S/C17H12ClN5O/c18-11-9-13(22-8-4-7-20-22)15-14(10-11)23(17(24)21-16(15)19)12-5-2-1-3-6-12/h1-10H,(H2,19,21,24)	XOHGFHCTMQOLST-UHFFFAOYSA-N	508048	US11130759, Cpd. No. 387::US11046691, Compound 387::4-amino-7-chloro-1-phenyl-5-pyrazol- 1-ylhydroquinazolin-2-one::US11084798, Cpd No 387	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508048&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608370	459093128							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071931	FC(F)(F)c1ccc2c(n1)n(-c1ccccc1Cl)c(=O)[nH]c2=O |(-5.33,.77,;-4,,;-4,-1.54,;-5.33,-.77,;-2.67,.77,;-2.67,2.31,;-1.33,3.08,;,2.31,;,.77,;-1.33,,;1.33,,;1.33,-1.54,;,-2.31,;,-3.85,;1.33,-4.62,;2.67,-3.85,;2.67,-2.31,;4,-1.54,;2.67,.77,;4,,;2.67,2.31,;1.33,3.08,;1.33,4.62,)|	InChI=1S/C14H7ClF3N3O2/c15-8-3-1-2-4-9(8)21-11-7(12(22)20-13(21)23)5-6-10(19-11)14(16,17)18/h1-6H,(H,20,22,23)	IGXCAMPXSFVRBQ-UHFFFAOYSA-N	508051	US11130759, Cpd. No. 388::US11046691, Compound 388::1-(2-chlorophenyl)-7-(trifluoromethyl)- 1,3-dihydropyridino[2,3-d]pyrimidine- 2,4-dione::US11084798, Cpd No 288	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508051&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162370676	459093131							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071932	FC(F)(F)CNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(4,6.16,;2.67,5.39,;1.33,6.16,;4,4.62,;2.67,3.85,;1.33,3.08,;1.33,1.54,;2.67,.77,;2.67,-.77,;4,-1.54,;1.33,-1.54,;1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;2.67,-5.39,;2.67,-3.85,;4,-3.08,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;,.77,;-4,-1.54,;-5.33,-.77,;-4,-3.08,;-5.33,-2.31,)|	InChI=1S/C16H9ClF6N4O/c17-9-3-1-2-4-10(9)27-13-8(5-6-11(25-13)16(21,22)23)12(26-14(27)28)24-7-15(18,19)20/h1-6H,7H2,(H,24,26,28)	MFAXOMZEWJKXSP-UHFFFAOYSA-N	508054	US11130759, Cpd. No. 389::US11046691, Compound 389::1-(2-chlorophenyl)-4-[(2,2,2-trifluoro- ethyl)amino]-7-(trifluoro-methyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 389	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508054&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608432	459093134							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071933	CNc1nc(=O)n(-c2cncc(O)c2)c2nc(ccc12)C(F)(F)F	InChI=1S/C14H10F3N5O2/c1-18-11-9-2-3-10(14(15,16)17)20-12(9)22(13(24)21-11)7-4-8(23)6-19-5-7/h2-6,23H,1H3,(H,18,21,24)	KLDVLVOUBVZUSH-UHFFFAOYSA-N	508057	US11130759, Cpd. No. 390::US11046691, Compound 390::1-(5-hydroxypyridin-3-yl)-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 390	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508057&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156514127	459093137							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071934	CNc1nc(=O)n(-c2ccnc(O)c2)c2nc(ccc12)C(F)(F)F	InChI=1S/C14H10F3N5O2/c1-18-11-8-2-3-9(14(15,16)17)20-12(8)22(13(24)21-11)7-4-5-19-10(23)6-7/h2-6H,1H3,(H,19,23)(H,18,21,24)	MQRARXJTDZJGNK-UHFFFAOYSA-N	508060	US11130759, Cpd. No. 391::US11046691, Compound 391::1-(2-hydroxypyridin-4-yl)-4-(methyl- amino)-7-(trifluoromethyl)-pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 391	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508060&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608766	459093140							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071935	CNc1nc(=O)n(-c2cnccc2O)c2nc(ccc12)C(F)(F)F |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.93,;,.38,;-1.33,-.38,;-2.67,.38,;-2.67,1.93,;-1.33,2.69,;,1.93,;-4,-.38,;-5.33,.39,;-4,-1.92,;-5.33,-1.15,)|	InChI=1S/C14H10F3N5O2/c1-18-11-7-2-3-10(14(15,16)17)20-12(7)22(13(24)21-11)8-6-19-5-4-9(8)23/h2-6H,1H3,(H,19,23)(H,18,21,24)	WBSVQWTVBRKHFR-UHFFFAOYSA-N	508063	US11130759, Cpd. No. 392::US11046691, Compound 392::1-(4-hydroxypyridin-3-yl)-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 392	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508063&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608615	459093143							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071936	CNc1nc(=O)n(-c2cc(O)ccn2)c2nc(ccc12)C(F)(F)F	InChI=1S/C14H10F3N5O2/c1-18-11-8-2-3-9(14(15,16)17)20-12(8)22(13(24)21-11)10-6-7(23)4-5-19-10/h2-6H,1H3,(H,19,23)(H,18,21,24)	NOAYKEYDSYXBGM-UHFFFAOYSA-N	508066	US11130759, Cpd. No. 393::US11046691, Compound 393::1-(5-hydroxypyridin-2-yl)-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 393	S-adenosylmethionine synthase isoform type-2	Homo sapiens		>10000							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508066&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609049	459093146							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071937	CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C#C	InChI=1S/C17H13N3O/c1-3-12-9-10-14-15(11-12)20(13-7-5-4-6-8-13)17(21)19-16(14)18-2/h1,4-11H,2H3,(H,18,19,21)	XIMMMRYDNZXOSB-UHFFFAOYSA-N	508069	US11130759, Cpd. No. 394::US11046691, Compound 394::7-ethynyl-4-(methylamino)-1-phenyl- hydroquinazolin-2-one::US11084798, Cpd No 394	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508069&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608316	459093149							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071938	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |r,wD:1.0,(-.34,6.43,;.56,5.18,;2.1,5.18,;2.58,3.72,;1.33,2.81,;.09,3.72,;1.33,1.27,;2.67,.5,;2.67,-1.04,;4,-1.81,;1.33,-1.81,;1.33,-3.35,;2.67,-4.12,;2.67,-5.66,;1.33,-6.43,;,-5.66,;,-4.12,;-1.33,-3.35,;,-1.04,;-1.33,-1.81,;-2.67,-1.04,;-2.67,.5,;-1.33,1.27,;,.5,;-4,-1.81,;-5.33,-1.04,;-4,-3.35,;-5.33,-2.58,)|	InChI=1S/C19H15ClF3N3O2/c20-14-3-1-2-4-15(14)26-16-9-11(19(21,22)23)5-6-13(16)17(24-18(26)28)25-8-7-12(27)10-25/h1-6,9,12,27H,7-8,10H2	ZXHHIXFUHOWROB-UHFFFAOYSA-N	508072	US11130759, Cpd. No. 395::US11046691, Compound 395::4-((3R)-3-hydroxypyrrolidin-1-yl)-1-(2- chlorophenyl)-7- (trifluoromethyl)hydro-quinazolin-2- one::US11084798, Cpd No 395	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508072	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508072&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933694	459093152							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071939	COc1nc(=O)n(-c2ccccc2)c2nc(C)ccc12	InChI=1S/C15H13N3O2/c1-10-8-9-12-13(16-10)18(11-6-4-3-5-7-11)15(19)17-14(12)20-2/h3-9H,1-2H3	RVZCPANLVXLIRF-UHFFFAOYSA-N	508075	US11046691, Compound 396::4-methoxy-7-methyl-1-phenylpyrido- [2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 396	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508075&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609053	459093155							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071940	Cc1ccc2c(NCC(F)(F)F)nc(=O)n(-c3ccccc3)c2n1	InChI=1S/C16H13F3N4O/c1-10-7-8-12-13(20-9-16(17,18)19)22-15(24)23(14(12)21-10)11-5-3-2-4-6-11/h2-8H,9H2,1H3,(H,20,22,24)	AFZBIAKQNDQUQE-UHFFFAOYSA-N	508078	US11130759, Cpd. No. 397::US11046691, Compound 397::7-methyl-1-phenyl-4-[(2,2,2-trifluoro- ethyl)amino]pyrido[2,3-d]pyrimidin- 2(1H)-one::US11084798, Cpd No 397	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508078&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608390	459093158							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071941	Cc1ccc2c(NCC(F)F)nc(=O)n(-c3ccccc3)c2n1	InChI=1S/C16H14F2N4O/c1-10-7-8-12-14(19-9-13(17)18)21-16(23)22(15(12)20-10)11-5-3-2-4-6-11/h2-8,13H,9H2,1H3,(H,19,21,23)	KKVROPSVCYDBON-UHFFFAOYSA-N	508081	US11130759, Cpd. No. 398::US11046691, Compound 398::4-[(2,2-difluoroethyl)amino]-7-methyl- 1-phenylpyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 398	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508081&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608218	459093161							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071942	COc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C1CC1	InChI=1S/C18H16N2O2/c1-22-17-15-10-9-13(12-7-8-12)11-16(15)20(18(21)19-17)14-5-3-2-4-6-14/h2-6,9-12H,7-8H2,1H3	AWCKMFKTAFUKTA-UHFFFAOYSA-N	508084	US11130759, Cpd. No. 399::US11046691, Compound 399::7-cyclopropyl-4-methoxy-1-phenyl- hydroquinazolin-2-one::US11084798, Cpd No 399	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508084&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609044	459093164							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071943	Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C1CC1	InChI=1S/C17H15N3O/c18-16-14-9-8-12(11-6-7-11)10-15(14)20(17(21)19-16)13-4-2-1-3-5-13/h1-5,8-11H,6-7H2,(H2,18,19,21)	RBRNSPZQKDZZSM-UHFFFAOYSA-N	508086	US11130759, Cpd. No. 400::US11046691, Compound 400::4-amino-7-cyclopropyl-1-phenylhydro- quinazolin-2-one::US11084798, Cpd No 400	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508086&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608944	459093165							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071944	CNc1nc(=O)n(-c2cccc(Br)c2)c2cc(Cl)ccc12	InChI=1S/C15H11BrClN3O/c1-18-14-12-6-5-10(17)8-13(12)20(15(21)19-14)11-4-2-3-9(16)7-11/h2-8H,1H3,(H,18,19,21)	STPOSVIVIREYGQ-UHFFFAOYSA-N	508089	US11130759, Cpd. No. 401::US11046691, Compound 401::1-(3-bromophenyl)-7-chloro-4- (methylamino)hydroquinazolin-2-one::US11084798, Cpd No 401	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508089&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608811	459093168							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071945	CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(OCCN)c12	InChI=1S/C17H17ClN4O2/c1-20-16-15-13(9-11(18)10-14(15)24-8-7-19)22(17(23)21-16)12-5-3-2-4-6-12/h2-6,9-10H,7-8,19H2,1H3,(H,20,21,23)	YRETZDAYCIPSFO-UHFFFAOYSA-N	508092	US11130759, Cpd. No. 402::US11046691, Compound 402::5-(2-aminoethoxy)-7-chloro-4-(methyl- amino)-1-phenylhydroquinazolin-2-one::US11084798, Cpd No 402	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508092&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608327	459093171							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071946	CS(=O)(=O)CCNc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(cc12)C#N |(-1.25,4.05,;-.48,5.38,;-1.82,6.15,;.29,6.72,;.85,4.61,;.85,3.07,;2.18,2.3,;2.18,.76,;3.52,-.01,;3.52,-1.55,;4.85,-2.32,;2.18,-2.32,;2.18,-3.86,;.85,-4.63,;.85,-6.17,;2.18,-6.94,;3.52,-6.17,;3.52,-4.63,;4.85,-3.86,;.85,-1.55,;-.48,-2.32,;-1.82,-1.55,;-3.15,-2.32,;-3.92,-3.65,;-4.69,-2.32,;-1.82,-.01,;-.48,.76,;.85,-.01,;-3.15,.76,;-4.48,1.53,)|	InChI=1S/C21H19ClN4O3S/c1-30(28,29)9-8-24-20-16-10-14(12-23)15(13-6-7-13)11-19(16)26(21(27)25-20)18-5-3-2-4-17(18)22/h2-5,10-11,13H,6-9H2,1H3,(H,24,25,27)	GMQQZANRISQFCL-UHFFFAOYSA-N	508095	US11130759, Cpd. No. 403::US11046691, Compound 403::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-(methylsulfonyl)ethyl)amino)-2- oxo-1,2-dihydroquinazoline-6- carbonitrile::US11084798, Cpd No 403	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 5500							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508095&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608637	459093174							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071947	F[C@@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |r,wU:1.0,wD:3.4,(4.2,2.36,;3.8,3.85,;3.8,5.39,;2.47,4.62,;1.13,3.85,;1.13,2.31,;2.47,1.54,;2.47,,;3.8,-.77,;1.13,-.77,;1.13,-2.31,;2.47,-3.08,;2.47,-4.62,;1.13,-5.39,;-.2,-4.62,;-.2,-3.08,;-1.53,-2.31,;-.2,,;-1.53,-.77,;-2.87,,;-4.2,-.77,;-5.38,.22,;-6.56,1.21,;-5.11,1.74,;-6.83,-.31,;-2.87,1.54,;-1.53,2.31,;-.2,1.54,)|	InChI=1S/C18H12ClF4N3O2/c19-11-3-1-2-4-14(11)26-15-7-9(28-18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	CPLJBLXSCDZION-UHFFFAOYSA-N	508097	US11130759, Cpd. No. 740::US11046691, Compound 404::4-[((1R,2R)-2-fluorocyclopropyl)- amino]-1-(2-chlorophenyl)-7- (trifluoromethoxy)hydroquinazolin-2- one::US11084798, Cpd No 404	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508097&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147265774	459093176							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071948	COc1nc(=O)n(-c2cccnc2C)c2cc(ccc12)C(F)(F)F |(2.21,5.04,;.95,4.17,;1.07,2.63,;2.47,1.97,;2.59,.44,;3.99,-.22,;1.33,-.44,;1.46,-1.97,;2.85,-2.63,;2.98,-4.17,;1.71,-5.04,;.32,-4.39,;.19,-2.85,;-1.2,-2.19,;-.06,.22,;-1.33,-.66,;-2.72,-0,;-2.85,1.53,;-1.58,2.41,;-.19,1.75,;-3.99,-.88,;-5.38,-.22,;-3.86,-2.42,;-5.25,-1.76,)|	InChI=1S/C16H12F3N3O2/c1-9-12(4-3-7-20-9)22-13-8-10(16(17,18)19)5-6-11(13)14(24-2)21-15(22)23/h3-8H,1-2H3	IMDXHHMLPXYAHI-UHFFFAOYSA-N	508100	US11130759, Cpd. No. 405::US11046691, Compound 405::4-methoxy-7-methyl-1-(2-methyl- pyridin-3-yl)quinazolin-2(1H)-one::US11084798, Cpd No 405	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508100&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150572659	459093179							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071949	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(cc(OC(F)F)c12)C1CC1 |(.77,5,;2.1,4.23,;2.1,2.69,;3.44,1.92,;3.44,.38,;4.77,-.38,;2.1,-.39,;2.1,-1.93,;.77,-2.69,;.77,-4.23,;2.1,-5,;3.44,-4.23,;3.44,-2.69,;4.77,-1.93,;.77,.38,;-.56,-.38,;-1.9,.38,;-1.9,1.93,;-.56,2.69,;-.56,4.23,;.88,4.76,;2.06,3.77,;1.15,6.28,;.77,1.92,;-3.23,-.38,;-4.77,-.38,;-4,-1.72,)|	InChI=1S/C19H16ClF2N3O2/c1-23-17-16-14(8-11(10-6-7-10)9-15(16)27-18(21)22)25(19(26)24-17)13-5-3-2-4-12(13)20/h2-5,8-10,18H,6-7H2,1H3,(H,23,24,26)	HQSMRKSUTCNGMT-UHFFFAOYSA-N	508102	US11130759, Cpd. No. 406::US11046691, Compound 406::5-(difluoromethoxy)-1-(2- chlorophenyl)-7-cyclopropyl-4- (methylamino)hydro-quinazolin-2-one::US11084798, Cpd No 406	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 350							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508102&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609003	459093181							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071950	COc1cc(cc2n(-c3ccccc3Cl)c(=O)nc(NCC3(F)CC3)c12)C1CC1 |(.88,3.32,;-.56,2.8,;-.56,1.26,;-1.9,.49,;-1.9,-1.05,;-.56,-1.82,;.77,-1.05,;2.1,-1.82,;2.1,-3.36,;3.44,-4.13,;3.44,-5.67,;2.1,-6.44,;.77,-5.67,;.77,-4.13,;-.56,-3.36,;3.44,-1.05,;4.77,-1.82,;3.44,.49,;2.1,1.26,;2.1,2.8,;3.44,3.57,;3.44,5.11,;1.95,4.71,;4.21,6.44,;2.67,6.44,;.77,.49,;-3.23,-1.82,;-4.77,-1.82,;-4,-3.16,)|	InChI=1S/C22H21ClFN3O2/c1-29-18-11-14(13-6-7-13)10-17-19(18)20(25-12-22(24)8-9-22)26-21(28)27(17)16-5-3-2-4-15(16)23/h2-5,10-11,13H,6-9,12H2,1H3,(H,25,26,28)	SQVQBVVWMHUHMT-UHFFFAOYSA-N	508105	US11130759, Cpd. No. 407::US11046691, Compound 407::1-(2-chlorophenyl)-7-cyclopropyl-4- {[(fluorocyclopropyl)methyl]amino}-5- methoxyhydroquinazolin-2-one::US11084798, Cpd No 407	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508105&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608935	459093184							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071951	Clc1ccccc1-n1c2cc(C3CC3)c(cc2c(NCC2CCO2)nc1=O)C#N |w:19.22,(-.56,-3.78,;.77,-4.55,;.77,-6.09,;2.1,-6.86,;3.44,-6.09,;3.44,-4.55,;2.1,-3.78,;2.1,-2.24,;.77,-1.47,;-.56,-2.24,;-1.9,-1.47,;-3.23,-2.24,;-4.77,-2.24,;-4,-3.58,;-1.9,.07,;-.56,.84,;.77,.07,;2.1,.84,;2.1,2.38,;3.44,3.15,;3.44,4.69,;4.53,5.78,;3.44,6.86,;2.35,5.78,;3.44,.07,;3.44,-1.47,;4.77,-2.24,;-3.23,.84,;-4.56,1.61,)|	InChI=1S/C22H19ClN4O2/c23-18-3-1-2-4-19(18)27-20-10-16(13-5-6-13)14(11-24)9-17(20)21(26-22(27)28)25-12-15-7-8-29-15/h1-4,9-10,13,15H,5-8,12H2,(H,25,26,28)	JTKLDPFLLQULBG-UHFFFAOYSA-N	508108	US11046691, Compound 408::1-(2-chlorophenyl)-7-cyclopropyl-4- ((oxetan-2-ylmethyl)amino)-2-oxo-1,2- dihydroquinazoline-6-carbonitrile::US11084798, Cpd No 408	S-adenosylmethionine synthase isoform type-2	Homo sapiens		 750							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508108&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608219	459093187							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071952	Clc1ccccc1-n1c2cc(C3CC3)c(cc2c(NCC2CC2)nc1=O)C#N |(-.56,-3.36,;.77,-4.13,;.77,-5.67,;2.1,-6.44,;3.44,-5.67,;3.44,-4.13,;2.1,-3.36,;2.1,-1.82,;.77,-1.05,;-.56,-1.82,;-1.9,-1.05,;-3.23,-1.82,;-4.77,-1.82,;-4,-3.16,;-1.9,.49,;-.56,1.26,;.77,.49,;2.1,1.26,;2.1,2.8,;3.44,3.57,;3.44,5.11,;4.21,6.44,;2.67,6.44,;3.44,.49,;3.44,-1.05,;4.77,-1.82,;-3.23,1.26,;-4.56,2.03,)|	InChI=1S/C22H19ClN4O/c23-18-3-1-2-4-19(18)27-20-10-16(14-7-8-14)15(11-24)9-17(20)21(26-22(27)28)25-12-13-5-6-13/h1-4,9-10,13-14H,5-8,12H2,(H,25,26,28)	MMKIKQGQOFBFDS-UHFFFAOYSA-N	508111	US11130759, Cpd. No. 409::US11046691, Compound 409::1-(2-chlorophenyl)-7-cyclopropyl-4- ((cyclopropylmethyl)amino)-2-oxo-1,2- dihydroquinazoline-6-carbonitrile::US11084798, Cpd No 409	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508111&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608982	459093190							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071953	CCc1cc(cc2n(-c3ccccc3C)c(=O)nc(NC)c12)C1CC1 |(-1.9,5,;-.56,4.23,;-.56,2.69,;-1.9,1.93,;-1.9,.38,;-.56,-.38,;.77,.38,;2.1,-.39,;2.1,-1.93,;3.44,-2.69,;3.44,-4.23,;2.1,-5,;.77,-4.23,;.77,-2.69,;-.56,-1.93,;3.44,.38,;4.77,-.38,;3.44,1.92,;2.1,2.69,;2.1,4.23,;.77,5,;.77,1.92,;-3.23,-.38,;-4.77,-.38,;-4,-1.72,)|	InChI=1S/C21H23N3O/c1-4-14-11-16(15-9-10-15)12-18-19(14)20(22-3)23-21(25)24(18)17-8-6-5-7-13(17)2/h5-8,11-12,15H,4,9-10H2,1-3H3,(H,22,23,25)	JPAKAPBKMUNLEJ-UHFFFAOYSA-N	508114	US11130759, Cpd. No. 410::US11046691, Compound 410::7-cyclopropyl-5-ethyl-4- (methylamino)-1-(2- methylphenyl)hydroquinazolin-2-one::US11084798, Cpd No 410	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508114	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508114&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150716730	459093193							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071954	Clc1cc2c(NCC3CC3)nc(=O)n(-c3ccccc3Cl)c2cc1C1CC1 |(-3.26,1.26,;-1.92,.49,;-.59,1.26,;.74,.49,;2.08,1.26,;2.08,2.8,;3.41,3.57,;3.41,5.11,;4.18,6.44,;2.64,6.44,;3.41,.49,;3.41,-1.05,;4.74,-1.82,;2.08,-1.82,;2.08,-3.36,;3.41,-4.13,;3.41,-5.67,;2.08,-6.44,;.74,-5.67,;.74,-4.13,;-.59,-3.36,;.74,-1.05,;-.59,-1.82,;-1.92,-1.05,;-3.26,-1.82,;-4.74,-1.42,;-4.35,-2.91,)|	InChI=1S/C21H19Cl2N3O/c22-16-3-1-2-4-18(16)26-19-10-14(13-7-8-13)17(23)9-15(19)20(25-21(26)27)24-11-12-5-6-12/h1-4,9-10,12-13H,5-8,11H2,(H,24,25,27)	LZBGGALZBSWIKW-UHFFFAOYSA-N	508117	US11130759, Cpd. No. 411::US11046691, Compound 411::6-chloro-1-(2-chlorophenyl)-7-cyclo- propyl-4-[(cyclopropylmethypamino]- hydroquinazolin-2-one::US11084798, Cpd No 411	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508117&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608464	459093196							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071955	Clc1cc2c(Nc3cnoc3)nc(=O)n(-c3ccccc3Cl)c2cc1Br |(-4.55,1.77,;-3.22,1,;-1.89,1.77,;-.55,1,;.78,1.77,;.78,3.31,;2.12,4.08,;3.52,3.45,;4.55,4.6,;3.78,5.93,;2.28,5.61,;2.12,1,;2.12,-.54,;3.45,-1.31,;.78,-1.31,;.78,-2.85,;2.12,-3.62,;2.12,-5.16,;.78,-5.93,;-.55,-5.16,;-.55,-3.62,;-1.89,-2.85,;-.55,-.54,;-1.89,-1.31,;-3.22,-.54,;-4.55,-1.31,)|	InChI=1S/C17H9BrCl2N4O2/c18-11-6-15-10(5-13(11)20)16(22-9-7-21-26-8-9)23-17(25)24(15)14-4-2-1-3-12(14)19/h1-8H,(H,22,23,25)	ZUKICUZVEINYDB-UHFFFAOYSA-N	507785	US11130759, Cpd. No. 412::US11046691, Compound 412::7-bromo-6-chloro-1-(2-chlorophenyl)- 4-(isoxazol-4-ylamino)hydroquinazolin- 2-one::US11084798, Cpd No 412	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507785&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152714997	459092870							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071956	F[C@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |r,wD:3.4,1.0,(5.54,3.57,;4.21,4.34,;3.44,5.67,;2.67,4.34,;1.33,3.57,;1.33,2.03,;2.67,1.26,;2.67,-.28,;4,-1.05,;1.33,-1.05,;1.33,-2.59,;2.67,-3.36,;2.67,-4.9,;1.33,-5.67,;,-4.9,;,-3.36,;-1.33,-2.59,;,-.28,;-1.33,-1.05,;-2.67,-.28,;-2.67,1.26,;-1.33,2.03,;,1.26,;-4,-1.05,;-5.54,-1.05,;-4.77,-2.39,)|	InChI=1S/C20H17ClFN3O/c21-14-3-1-2-4-17(14)25-18-9-12(11-5-6-11)7-8-13(18)19(24-20(25)26)23-16-10-15(16)22/h1-4,7-9,11,15-16H,5-6,10H2,(H,23,24,26)	OFKNVVVDSFLNGX-UHFFFAOYSA-N	507790	US11130759, Cpd. No. 413::US11046691, Compound 413::4-[((2S,1R)-2- fluorocyclopropyl)amino]-1-(2- chlorophenyl)-7-cyclopropyl- hydroquinazolin-2-one::US11084798, Cpd No 413	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507790&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608998	459092875							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071957	CNc1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(C)C	InChI=1S/C17H18N4O/c1-11(2)14-10-9-13-15(18-3)20-17(22)21(16(13)19-14)12-7-5-4-6-8-12/h4-11H,1-3H3,(H,18,20,22)	PCIDZYKNFVGWIT-UHFFFAOYSA-N	507794	US11130759, Cpd. No. 414::US11046691, Compound 414::4-(methylamino)-7-(methylethyl)-1- phenylpyrido[2,3-d]pyrimidin-2(1H)- 2-one::US11084798, Cpd No 414	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507794&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151430035	459092879							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071958	FC(F)(F)c1ncccc1-n1c2cc(ccc2c(NCC2CC2)nc1=O)C1CC1 |(-.56,-1.82,;-.56,-3.36,;-1.9,-4.13,;-1.9,-2.59,;.77,-4.13,;.77,-5.67,;2.1,-6.44,;3.44,-5.67,;3.44,-4.13,;2.1,-3.36,;2.1,-1.82,;.77,-1.05,;-.56,-1.82,;-1.9,-1.05,;-1.9,.49,;-.56,1.26,;.77,.49,;2.1,1.26,;2.1,2.8,;3.44,3.57,;3.44,5.11,;4.21,6.44,;2.67,6.44,;3.44,.49,;3.44,-1.05,;4.77,-1.82,;-3.23,-1.82,;-4.77,-1.82,;-4,-3.16,)|	InChI=1S/C21H19F3N4O/c22-21(23,24)18-16(2-1-9-25-18)28-17-10-14(13-5-6-13)7-8-15(17)19(27-20(28)29)26-11-12-3-4-12/h1-2,7-10,12-13H,3-6,11H2,(H,26,27,29)	LTVZYHMRWTUXLR-UHFFFAOYSA-N	507798	US11130759, Cpd. No. 415::US11046691, Compound 415::7-cyclopropyl-4-(((cyclopropylmethyl)- amino]-1-[2-(trifluoromethyl)(3- pyridyl)]hydroquinazolin-2-one::US11084798, Cpd No 415	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507798&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150999772	459092883							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071959	FC(F)Oc1ncccc1-n1c2cc(ccc2c(NCC2CC2)nc1=O)C1CC1 |(1.15,-1.32,;-.3,-1.85,;-1.48,-.86,;-.56,-3.36,;.77,-4.13,;.77,-5.67,;2.1,-6.44,;3.44,-5.67,;3.44,-4.13,;2.1,-3.36,;2.1,-1.82,;.77,-1.05,;-.56,-1.82,;-1.9,-1.05,;-1.9,.49,;-.56,1.26,;.77,.49,;2.1,1.26,;2.1,2.8,;3.44,3.57,;3.44,5.11,;4.21,6.44,;2.67,6.44,;3.44,.49,;3.44,-1.05,;4.77,-1.82,;-3.23,-1.82,;-4.77,-1.82,;-4,-3.16,)|	InChI=1S/C21H20F2N4O2/c22-20(23)29-19-16(2-1-9-24-19)27-17-10-14(13-5-6-13)7-8-15(17)18(26-21(27)28)25-11-12-3-4-12/h1-2,7-10,12-13,20H,3-6,11H2,(H,25,26,28)	VQUGDFPDENTYQJ-UHFFFAOYSA-N	507802	US11130759, Cpd. No. 416::US11046691, Compound 416::1-[2-(difluoromethoxy)(3--pyridyl)]-7- cyclopropyl-4-[(cyclopropylmethyl)- amino]hydroquinazolin-2-one::US11084798, Cpd No 416	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507802&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152178740	459092887							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071960	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(Br)cc12 |(.74,5,;2.08,4.23,;2.08,2.69,;3.41,1.92,;3.41,.38,;4.74,-.38,;2.08,-.39,;2.08,-1.93,;3.41,-2.69,;3.41,-4.23,;2.08,-5,;.74,-4.23,;.74,-2.69,;-.59,-1.93,;.74,.38,;-.59,-.38,;-1.92,.38,;-3.26,-.38,;-4.74,.01,;-4.35,-1.47,;-1.92,1.93,;-3.26,2.69,;-.59,2.69,;.74,1.92,)|	InChI=1S/C18H15BrClN3O/c1-21-17-12-8-13(19)11(10-6-7-10)9-16(12)23(18(24)22-17)15-5-3-2-4-14(15)20/h2-5,8-10H,6-7H2,1H3,(H,21,22,24)	YCZISPOGWNOJLF-UHFFFAOYSA-N	507806	US11130759, Cpd. No. 417::US11046691, Compound 417::6-bromo-1-(2-chlorophenyl)-7-cyclo- propyl-4-(methylamino)hydro- quinazolin-2-one::US11084798, Cpd No 417	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507806&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609068	459092891							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071961	F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |r,wU:3.4,wD:1.0,(4.77,3.57,;3.44,4.34,;2.67,5.67,;1.9,4.34,;.56,3.57,;.56,2.03,;1.9,1.26,;1.9,-.28,;3.23,-1.05,;.56,-1.05,;.56,-2.59,;1.9,-3.36,;1.9,-4.9,;.56,-5.67,;-.77,-4.9,;-.77,-3.36,;-2.1,-2.59,;-.77,-.28,;-2.1,-1.05,;-3.44,-.28,;-4.77,-1.05,;-5.95,-.06,;-7.13,.93,;-5.68,1.45,;-7.4,-.59,;-3.44,1.26,;-2.1,2.03,;-.77,1.26,)|	InChI=1S/C18H12ClF4N3O2/c19-11-3-1-2-4-14(11)26-15-7-9(28-18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	CPLJBLXSCDZION-UHFFFAOYSA-N	507810	US11130759, Cpd. No. 741::US11046691, Compound 418::1-(2-chlorophenyl)-4-(((1S,2S)-2- fluorocyclopropyl)amino)-7-(trifluoro- methoxy)quinazolin-2(1H)-one::US11084798, Cpd No 418	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507810&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608906	459092895							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071962	CNc1nc(=O)n(-c2cccc(CC(O)=O)c2)c2cc(Cl)ccc12	InChI=1S/C17H14ClN3O3/c1-19-16-13-6-5-11(18)9-14(13)21(17(24)20-16)12-4-2-3-10(7-12)8-15(22)23/h2-7,9H,8H2,1H3,(H,22,23)(H,19,20,24)	XSSZRIRMSALYSU-UHFFFAOYSA-N	507814	US11130759, Cpd. No. 419::US11046691, Compound 419::2-(3-(7-chloro-4-(methylamino)-2- oxoquinazolin-1(2H)-yl)phenyl)acetic acid::US11084798, Cpd No 419	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507814&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608460	459092899							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071963	CNc1nc(=O)n(-c2ccccc2)c2cc(cc(F)c12)C(F)(F)F	InChI=1S/C16H11F4N3O/c1-21-14-13-11(17)7-9(16(18,19)20)8-12(13)23(15(24)22-14)10-5-3-2-4-6-10/h2-8H,1H3,(H,21,22,24)	ZXCFXQGKYXSVHW-UHFFFAOYSA-N	507818	US11130759, Cpd. No. 420::US11046691, Compound 420::5-fluoro-4-(methylamino)-1-phenyl-7- (trifluoromethyl)hydroquinazolin-2-one::US11084798, Cpd No 420	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507818&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608564	459092903							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071964	FC(F)(F)c1ccc2c(Nc3ccncc3)nc(=O)n(-c3ccccc3Cl)c2n1 |(-6,-.77,;-4.67,-1.54,;-4.67,-3.08,;-6,-2.31,;-3.33,-.77,;-3.33,.77,;-2,1.54,;-.67,.77,;.67,1.54,;.67,3.08,;2,3.85,;3.33,3.08,;4.67,3.85,;4.67,5.39,;3.33,6.16,;2,5.39,;2,.77,;2,-.77,;3.33,-1.54,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;.67,-6.16,;-.67,-5.39,;-.67,-3.85,;-2,-3.08,;-.67,-.77,;-2,-1.54,)|	InChI=1S/C19H11ClF3N5O/c20-13-3-1-2-4-14(13)28-17-12(5-6-15(26-17)19(21,22)23)16(27-18(28)29)25-11-7-9-24-10-8-11/h1-10H,(H,24,25,27,29)	QYCQDNDTGKMOMS-UHFFFAOYSA-N	507822	US11130759, Cpd. No. 421::US11046691, Compound 421::1-(2-chlorophenyl)-4-(pyridin-4-yl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 421	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507822&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609054	459092907							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071965	FC(F)(F)c1ccc2c(OC3CC3)nc(=O)n(-c3ccccc3Cl)c2n1 |(-5.44,-.28,;-4.1,-1.05,;-4.1,-2.59,;-5.44,-1.82,;-2.77,-.28,;-2.77,1.26,;-1.44,2.03,;-.1,1.26,;1.23,2.03,;1.23,3.57,;2.56,4.34,;4.1,4.34,;3.33,5.67,;2.56,1.26,;2.56,-.28,;3.9,-1.05,;1.23,-1.05,;1.23,-2.59,;2.56,-3.36,;2.56,-4.9,;1.23,-5.67,;-.1,-4.9,;-.1,-3.36,;-1.44,-2.59,;-.1,-.28,;-1.44,-1.05,)|	InChI=1S/C17H11ClF3N3O2/c18-11-3-1-2-4-12(11)24-14-10(7-8-13(22-14)17(19,20)21)15(23-16(24)25)26-9-5-6-9/h1-4,7-9H,5-6H2	UFOIIBKQKFUIRV-UHFFFAOYSA-N	507825	US11130759, Cpd. No. 422::US11046691, Compound 422::1-(2-chlorophenyl)-4-cyclopropoxy-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 422	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507825&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608246	459092910							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071966	F[C@@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F |r|	InChI=1S/C18H13F4N3O/c19-13-9-14(13)23-16-12-7-6-10(18(20,21)22)8-15(12)25(17(26)24-16)11-4-2-1-3-5-11/h1-8,13-14H,9H2,(H,23,24,26)	UFSKLHVXDCCBMV-UHFFFAOYSA-N	507833	US11130759, Cpd. No. 424::US11046691, Compound 424::4-(((1S,2R)-2- fluorocyclopropyl)amino)-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 423	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507833&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151996206	459092918							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071967	COc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(.77,5,;2.1,4.23,;2.1,2.69,;3.44,1.92,;3.44,.38,;4.77,-.38,;2.1,-.39,;2.1,-1.93,;3.44,-2.69,;3.44,-4.23,;2.1,-5,;.77,-4.23,;.77,-2.69,;-.56,-1.93,;.77,.38,;-.56,-.38,;-1.9,.38,;-1.9,1.93,;-.56,2.69,;.77,1.92,;-3.23,-.38,;-4.77,-.38,;-4,-1.72,)|	InChI=1S/C18H15ClN2O2/c1-23-17-13-9-8-12(11-6-7-11)10-16(13)21(18(22)20-17)15-5-3-2-4-14(15)19/h2-5,8-11H,6-7H2,1H3	IHRGFSZSILAIMZ-UHFFFAOYSA-N	507829	US11130759, Cpd. No. 423::US11046691, Compound 423::1-(2-chlorophenyl)-7-cyclopropyl-4- methoxyhydroquinazolin-2-one::US11084798, Cpd No 424	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507829&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608523	459092914							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071968	CC(F)(F)c1ccc2c(NCC3CC3)nc(=O)n(-c3ccccc3Cl)c2c1 |(-5.44,.38,;-4.1,-.38,;-3.33,-1.72,;-5.19,-1.47,;-2.77,.38,;-2.77,1.93,;-1.44,2.69,;-.1,1.93,;1.23,2.69,;1.23,4.23,;2.56,5,;3.9,4.23,;4.67,2.9,;5.44,4.23,;2.56,1.93,;2.56,.38,;3.9,-.38,;1.23,-.38,;1.23,-1.93,;-.1,-2.69,;-.1,-4.23,;1.23,-5,;2.56,-4.23,;2.56,-2.69,;3.9,-1.93,;-.1,.38,;-1.44,-.38,)|	InChI=1S/C20H18ClF2N3O/c1-20(22,23)13-8-9-14-17(10-13)26(16-5-3-2-4-15(16)21)19(27)25-18(14)24-11-12-6-7-12/h2-5,8-10,12H,6-7,11H2,1H3,(H,24,25,27)	FKJVOTLGLPYSGO-UHFFFAOYSA-N	507836	US11046691, Compound 425::1-(2-chlorophenyl)-4-((cyclopropyl- methyl)amino)-7-(1,1-difluoroethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 425	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507836&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608561	459092921							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071969	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(3.44,5,;2.1,4.23,;2.1,2.69,;3.44,1.93,;3.44,.38,;4.77,-.38,;2.1,-.38,;2.1,-1.93,;.77,-2.69,;.77,-4.23,;2.1,-5,;3.44,-4.23,;3.44,-2.69,;4.77,-1.93,;.77,.38,;-.56,-.38,;-1.9,.38,;-1.9,1.93,;-.56,2.69,;.77,1.93,;-3.23,-.38,;-4.77,-.38,;-4,-1.72,)|	InChI=1S/C18H16ClN3O/c1-20-17-13-9-8-12(11-6-7-11)10-16(13)22(18(23)21-17)15-5-3-2-4-14(15)19/h2-5,8-11H,6-7H2,1H3,(H,20,21,23)	KQRIBGOBTCCQSR-UHFFFAOYSA-N	507840	US11130759, Cpd. No. 426::US11046691, Compound 426::1-(2-chlorophenyl)-7-cyclopropyl-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 426	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507840&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608993	459092925							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071970	Cc1ccccc1-n1c2cc(ccc2c(N[C@H]2CCNC2)nc1=O)C(F)(F)F |r,wD:16.17,(1.88,-4.62,;3.22,-3.85,;4.55,-4.62,;5.89,-3.85,;5.89,-2.31,;4.55,-1.54,;3.22,-2.31,;1.88,-1.54,;1.89,0,;3.22,.77,;3.22,2.31,;1.89,3.08,;.55,2.31,;.55,.77,;-.78,0,;-2.12,.77,;-3.45,0,;-4.86,.63,;-5.89,-.52,;-5.12,-1.85,;-3.61,-1.53,;-.78,-1.54,;.55,-2.31,;.55,-3.85,;4.55,3.08,;5.89,2.31,;4.55,4.62,;4.55,1.54,)|	InChI=1S/C20H19F3N4O/c1-12-4-2-3-5-16(12)27-17-10-13(20(21,22)23)6-7-15(17)18(26-19(27)28)25-14-8-9-24-11-14/h2-7,10,14,24H,8-9,11H2,1H3,(H,25,26,28)	PJKPBWSRSNHIPY-UHFFFAOYSA-N	507844	US11130759, Cpd. No. 427::US11046691, Compound 427::(S)-4-(pyrrolidin-3-ylamino)-1-(o- tolyl)-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 427	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507844&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608784	459092929							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071971	Cc1ccccc1-n1c2nc(ccc2c(nc1=O)N1CC[C@@H]1CO)C(F)(F)F |r,wD:21.25,(3.61,-.15,;3.61,-1.69,;4.94,-2.46,;4.94,-4,;3.61,-4.77,;2.28,-4,;2.28,-2.46,;.94,-1.69,;.94,-.15,;2.28,.62,;2.28,2.16,;.94,2.93,;-.39,2.16,;-.39,.62,;-1.72,-.15,;-1.73,-1.69,;-.39,-2.46,;-.39,-4,;-3.06,.62,;-4.55,.22,;-4.94,1.71,;-3.46,2.11,;-2.69,3.44,;-3.46,4.77,;3.61,2.93,;4.94,2.16,;3.61,4.47,;4.94,3.7,)|	InChI=1S/C19H17F3N4O2/c1-11-4-2-3-5-14(11)26-17-13(6-7-15(23-17)19(20,21)22)16(24-18(26)28)25-9-8-12(25)10-27/h2-7,12,27H,8-10H2,1H3	YMSGSIJEMXISIH-UHFFFAOYSA-N	508118	US11130759, Cpd. No. 428::US11046691, Compound 428::(R)-4-(2-(hydroxymethyl)azetidin-1- yl)-1-(o-tolyl)-7- (trifluoromethyppyrido-[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 428	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508118&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152547119	459093197							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071972	CNS(=O)(=O)CCNc1nc(=O)n(-c2ccccc2C)c2nc(ccc12)C(F)(F)F |(-6.67,-2.31,;-5.34,-1.54,;-5.33,0,;-6.67,.77,;-5.33,1.54,;-4,.77,;-2.67,0,;-1.33,.77,;-0,0,;-0,-1.54,;1.33,-2.31,;1.33,-3.85,;2.67,-1.54,;4,-2.31,;4,-3.85,;5.33,-4.62,;6.67,-3.85,;6.67,-2.31,;5.33,-1.54,;5.33,0,;2.67,0,;4,.77,;4,2.31,;2.67,3.08,;1.33,2.31,;1.33,.77,;5.34,3.08,;6.67,2.31,;5.34,4.62,;6.67,3.85,)|	InChI=1S/C18H18F3N5O3S/c1-11-5-3-4-6-13(11)26-16-12(7-8-14(24-16)18(19,20)21)15(25-17(26)27)23-9-10-30(28,29)22-2/h3-8,22H,9-10H2,1-2H3,(H,23,25,27)	UXQMNGUJMVRPIH-UHFFFAOYSA-N	508119	US11130759, Cpd. No. 429::US11046691, Compound 429::N-methyl-24(2-oxo-1-(o-tolyl)-7- (trifluoromethyl)-1,2- dihydropyrido[2,3-d]pyrimidin-4- yl)amino)ethane-1-sulfonamide::US11084798, Cpd No 429	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508119&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608420	459093198							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071973	CNS(=O)(=O)CCCNc1nc(=O)n(-c2ccccc2C)c2nc(ccc12)C(F)(F)F |(-7.34,3.08,;-6,2.31,;-6,.77,;-7.34,0,;-6,-.77,;-4.67,0,;-3.33,.77,;-2,0,;-.67,.77,;.67,0,;.67,-1.54,;2,-2.31,;2,-3.85,;3.33,-1.54,;4.67,-2.31,;4.67,-3.85,;6,-4.62,;7.33,-3.85,;7.33,-2.31,;6,-1.54,;6,0,;3.33,0,;4.67,.77,;4.67,2.31,;3.33,3.08,;2,2.31,;2,.77,;6,3.08,;7.34,2.31,;6,4.62,;7.34,3.85,)|	InChI=1S/C19H20F3N5O3S/c1-12-6-3-4-7-14(12)27-17-13(8-9-15(25-17)19(20,21)22)16(26-18(27)28)24-10-5-11-31(29,30)23-2/h3-4,6-9,23H,5,10-11H2,1-2H3,(H,24,26,28)	JOUAJZDUYQQGFE-UHFFFAOYSA-N	508120	US11130759, Cpd. No. 430::US11046691, Compound 430::N-methyl-3-((2-oxo-1-(o-tolyl)-7- (trifluoromethyl)-1,2- dihydropyrido[2,3-d]pyrimidin-4- yl)amino)propane-1-sulfonamide::US11084798, Cpd No 430	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508120&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608895	459093199							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071974	Cc1ccccc1-n1c2nc(ccc2c(NCCS(=O)(=O)NC2CC2)nc1=O)C(F)(F)F |(6.1,,;6.1,-1.54,;7.44,-2.31,;7.44,-3.85,;6.1,-4.62,;4.77,-3.85,;4.77,-2.31,;3.44,-1.54,;3.44,,;4.77,.77,;4.77,2.31,;3.44,3.08,;2.1,2.31,;2.1,.77,;.77,,;-.56,.77,;-1.9,,;-3.23,.77,;-4.56,,;-5.9,.77,;-4.56,1.54,;-4.56,-1.54,;-5.9,-2.31,;-7.44,-2.31,;-6.67,-3.64,;.77,-1.54,;2.1,-2.31,;2.1,-3.85,;6.1,3.08,;7.44,2.31,;6.1,4.62,;7.44,3.85,)|	InChI=1S/C20H20F3N5O3S/c1-12-4-2-3-5-15(12)28-18-14(8-9-16(25-18)20(21,22)23)17(26-19(28)29)24-10-11-32(30,31)27-13-6-7-13/h2-5,8-9,13,27H,6-7,10-11H2,1H3,(H,24,26,29)	QBNRPAIZBFMGNW-UHFFFAOYSA-N	508121	US11130759, Cpd. No. 431::US11046691, Compound 431::N-cyclopropyl-2-((2-oxo-1-(o-tolyl)-7- (trifluoromethyl)-1,2- dihydropyrido[2,3-d]pyrimidin-4- yl)amino)ethane-1-sulfonamide::US11084798, Cpd No 431	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508121&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608443	459093200							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071975	Cc1ccccc1-n1c2nc(ccc2c(N[C@H]2C[C@H]2F)nc1=O)C(F)(F)F |r,wD:16.17,18.21,(4.1,,;4.1,-1.54,;5.44,-2.31,;5.44,-3.85,;4.1,-4.62,;2.77,-3.85,;2.77,-2.31,;1.44,-1.54,;1.44,,;2.77,.77,;2.77,2.31,;1.44,3.08,;.1,2.31,;.1,.77,;-1.23,,;-2.56,.77,;-3.9,,;-5.44,,;-4.67,-1.33,;-4.67,-2.87,;-1.23,-1.54,;.1,-2.31,;.1,-3.85,;4.1,3.08,;5.44,2.31,;4.1,4.62,;5.44,3.85,)|	InChI=1S/C18H14F4N4O/c1-9-4-2-3-5-13(9)26-16-10(6-7-14(24-16)18(20,21)22)15(25-17(26)27)23-12-8-11(12)19/h2-7,11-12H,8H2,1H3,(H,23,25,27)	ZWGFMUFSBVPQRM-UHFFFAOYSA-N	508122	US11130759, Cpd. No. 432::US11046691, Compound 432::4-(((1S,2R)-2- fluorocyclopropyl)amino)-1-(o-tolyl)-7- (trifluoromethyl)pyrido-[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 432	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508122	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508122&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608385	459093201							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071976	Cc1ccccc1-n1c2nc(ccc2c(N[C@@H]2C[C@@H]2F)nc1=O)C(F)(F)F |r,wU:16.17,18.21,(4.1,,;4.1,-1.54,;5.44,-2.31,;5.44,-3.85,;4.1,-4.62,;2.77,-3.85,;2.77,-2.31,;1.44,-1.54,;1.44,,;2.77,.77,;2.77,2.31,;1.44,3.08,;.1,2.31,;.1,.77,;-1.23,,;-2.56,.77,;-3.9,,;-5.44,,;-4.67,-1.33,;-4.67,-2.87,;-1.23,-1.54,;.1,-2.31,;.1,-3.85,;4.1,3.08,;5.44,2.31,;4.1,4.62,;5.44,3.85,)|	InChI=1S/C18H14F4N4O/c1-9-4-2-3-5-13(9)26-16-10(6-7-14(24-16)18(20,21)22)15(25-17(26)27)23-12-8-11(12)19/h2-7,11-12H,8H2,1H3,(H,23,25,27)	ZWGFMUFSBVPQRM-UHFFFAOYSA-N	508123	US11130759, Cpd. No. 433::US11046691, Compound 433::4-(((1R,2S)-2- fluorocyclopropyl)amino)-1-(o-tolyl)-7- (trifluoromethyl)pyrido-[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 433	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508123&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609013	459093202							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071977	CN(C)S(=O)(=O)CCCNc1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F |(-7.34,3.08,;-6,2.31,;-4.67,3.08,;-6,.77,;-7.34,,;-6,-.77,;-4.67,,;-3.33,.77,;-2,,;-.67,.77,;.67,,;.67,-1.54,;2,-2.31,;2,-3.85,;3.33,-1.54,;4.67,-2.31,;6,-1.54,;7.34,-2.31,;7.34,-3.85,;6,-4.62,;4.67,-3.85,;3.33,-4.62,;3.33,,;4.67,.77,;4.67,2.31,;3.33,3.08,;2,2.31,;2,.77,;6,3.08,;7.34,2.31,;6,4.62,;6,1.54,)|	InChI=1S/C21H23F3N4O3S/c1-14-7-4-5-8-17(14)28-18-13-15(21(22,23)24)9-10-16(18)19(26-20(28)29)25-11-6-12-32(30,31)27(2)3/h4-5,7-10,13H,6,11-12H2,1-3H3,(H,25,26,29)	ZUTLDWZVLOMFOV-UHFFFAOYSA-N	508124	US11130759, Cpd. No. 434::US11046691, Compound 434::N,N-dimethyl-3-((2-oxo-1-(o-tolyl)-7- (trifluoromethyl)-1,2- dihydroquinazolin-4-yl)amino)propane- 1-sulfonamide::US11084798, Cpd No 434	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508124	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508124&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608872	459093203							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071978	CN(C)S(=O)(=O)CCNc1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F |(-4,-2.31,;-5.33,-1.54,;-6.67,-2.31,;-5.33,,;-6.67,.77,;-5.33,1.54,;-4,.77,;-2.67,,;-1.33,.77,;;,-1.54,;1.33,-2.31,;1.33,-3.85,;2.67,-1.54,;4,-2.31,;5.33,-1.54,;6.67,-2.31,;6.67,-3.85,;5.33,-4.62,;4,-3.85,;2.67,-4.62,;2.67,,;4,.77,;4,2.31,;2.67,3.08,;1.33,2.31,;1.33,.77,;5.33,3.08,;6.67,2.31,;5.33,4.62,;5.33,1.54,)|	InChI=1S/C20H21F3N4O3S/c1-13-6-4-5-7-16(13)27-17-12-14(20(21,22)23)8-9-15(17)18(25-19(27)28)24-10-11-31(29,30)26(2)3/h4-9,12H,10-11H2,1-3H3,(H,24,25,28)	YPLSTXSAALCKRA-UHFFFAOYSA-N	508125	US11130759, Cpd. No. 435::US11046691, Compound 435::N,N-dimethyl-2-((2-oxo-1-(o-tolyl)-7- (trifluoromethyl)-1,2- dihydroquinazolin-4-yl)amino)ethane- 1-sulfonamide::US11084798, Cpd No 435	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508125&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149401402	459093204							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071979	Cc1ccccc1-n1c2cc(ccc2c(N[C@@H]2CCN(C2)C(=O)OC(C)(C)C)nc1=O)C(F)(F)F |r,wU:16.17,(2.58,-4.14,;3.91,-3.37,;5.25,-4.14,;6.58,-3.37,;6.58,-1.83,;5.25,-1.06,;3.91,-1.83,;2.58,-1.06,;2.58,.48,;3.91,1.25,;3.91,2.79,;2.58,3.56,;1.25,2.79,;1.25,1.25,;-.09,.48,;-1.42,1.25,;-2.76,.48,;-4.16,1.11,;-5.19,-.03,;-4.42,-1.37,;-2.92,-1.05,;-5.05,-2.77,;-6.58,-2.93,;-4.14,-4.02,;-2.61,-3.86,;-1.99,-2.45,;-1.71,-5.1,;-1.08,-3.7,;-.09,-1.06,;1.25,-1.83,;1.25,-3.37,;5.25,3.56,;6.58,2.79,;5.25,5.1,;5.25,2.02,)|	InChI=1S/C25H27F3N4O3/c1-15-7-5-6-8-19(15)32-20-13-16(25(26,27)28)9-10-18(20)21(30-22(32)33)29-17-11-12-31(14-17)23(34)35-24(2,3)4/h5-10,13,17H,11-12,14H2,1-4H3,(H,29,30,33)	PHUQBEZFGUDTGI-UHFFFAOYSA-N	508126	US11130759, Cpd. No. 436::US11046691, Compound 436::tert-butyl (R)-3-((2-oxo-1-(o-tolyl)-7- (trifluoromethyl)-1,2- dihydroquinazolin-4- yl)amino)pyrrolidine-1-carboxylate::US11084798, Cpd No 436	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508126&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608575	459093205							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071980	Cc1ccccc1-n1c2cc(ccc2c(NCCS(=O)(=O)N2CCOCC2)nc1=O)C(F)(F)F |(2.67,-4.62,;4,-3.85,;5.33,-4.62,;6.67,-3.85,;6.67,-2.31,;5.33,-1.54,;4,-2.31,;2.67,-1.54,;2.67,,;4,.77,;4,2.31,;2.67,3.08,;1.33,2.31,;1.33,.77,;;-1.33,.77,;-2.67,,;-4,.77,;-5.33,,;-6.67,.77,;-5.33,1.54,;-5.33,-1.54,;-6.67,-2.31,;-6.67,-3.85,;-5.33,-4.62,;-4,-3.85,;-4,-2.31,;,-1.54,;1.33,-2.31,;1.33,-3.85,;5.33,3.08,;6.67,2.31,;5.33,4.62,;5.33,1.54,)|	InChI=1S/C22H23F3N4O4S/c1-15-4-2-3-5-18(15)29-19-14-16(22(23,24)25)6-7-17(19)20(27-21(29)30)26-8-13-34(31,32)28-9-11-33-12-10-28/h2-7,14H,8-13H2,1H3,(H,26,27,30)	JSLIWDPHBWCWMN-UHFFFAOYSA-N	508127	US11130759, Cpd. No. 437::US11046691, Compound 437::4-((2- (morpholinosulfonyl)ethyl)amino)-1-(o- tolyl)-7-(trifluoromethyl)-quinazolin- 2(1H)-one::US11084798, Cpd No 437	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508127&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150734059	459093206							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071981	CN[C@H]1CCN(C1)c1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F |r,wD:2.1,(-4.17,4.95,;-5.08,3.7,;-4.45,2.29,;-5.22,.96,;-4.19,-.18,;-2.78,.44,;-2.94,1.97,;-1.45,-.33,;-1.45,-1.87,;-.11,-2.64,;-.11,-4.18,;1.22,-1.87,;2.55,-2.64,;3.89,-1.87,;5.22,-2.64,;5.22,-4.18,;3.89,-4.95,;2.55,-4.18,;1.22,-4.95,;1.22,-.33,;2.55,.44,;2.55,1.98,;1.22,2.75,;-.11,1.98,;-.11,.44,;3.89,2.75,;5.22,1.98,;3.89,4.29,;3.89,1.21,)|	InChI=1S/C21H21F3N4O/c1-13-5-3-4-6-17(13)28-18-11-14(21(22,23)24)7-8-16(18)19(26-20(28)29)27-10-9-15(12-27)25-2/h3-8,11,15,25H,9-10,12H2,1-2H3	IUHUDBGWPQABEL-UHFFFAOYSA-N	508128	US11130759, Cpd. No. 438::US11046691, Compound 438::(S)-4-(3-(methylamino)pyrrolidin-1-yl)- 1-(o-tolyl)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 438	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508128	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508128&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150613022	459093207							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071982	Cc1ccccc1-n1c2cc(ccc2c(NCCS(=O)(=O)NC2CC2)nc1=O)C(F)(F)F |(3.44,-4.62,;4.77,-3.85,;6.1,-4.62,;7.44,-3.85,;7.44,-2.31,;6.1,-1.54,;4.77,-2.31,;3.44,-1.54,;3.44,,;4.77,.77,;4.77,2.31,;3.44,3.08,;2.1,2.31,;2.1,.77,;.77,,;-.56,.77,;-1.9,,;-3.23,.77,;-4.56,,;-5.9,.77,;-4.56,1.54,;-4.56,-1.54,;-5.9,-2.31,;-7.44,-2.31,;-6.67,-3.64,;.77,-1.54,;2.1,-2.31,;2.1,-3.85,;6.1,3.08,;7.44,2.31,;6.1,4.62,;6.1,1.54,)|	InChI=1S/C21H21F3N4O3S/c1-13-4-2-3-5-17(13)28-18-12-14(21(22,23)24)6-9-16(18)19(26-20(28)29)25-10-11-32(30,31)27-15-7-8-15/h2-6,9,12,15,27H,7-8,10-11H2,1H3,(H,25,26,29)	JSBILOUDVCDKHP-UHFFFAOYSA-N	508129	US11130759, Cpd. No. 439::US11046691, Compound 439::N-cyclopropyl-2-((2-oxo-1-(o-tolyl)-7- (trifluoromethyl)-1,2- dihydroquinazolin-4-yl)amino)ethane- 1-sulfonamide::US11084798, Cpd No 439	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508129	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508129&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148115080	459093208							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071983	Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1CC[C@@H]1CO)C(F)(F)F |r,wD:21.25,(.94,-4.62,;2.28,-3.85,;3.61,-4.62,;4.94,-3.85,;4.94,-2.31,;3.61,-1.54,;2.28,-2.31,;.94,-1.54,;.94,,;2.28,.77,;2.28,2.31,;.94,3.08,;-.39,2.31,;-.39,.77,;-1.72,,;-1.72,-1.54,;-.39,-2.31,;-.39,-3.85,;-3.06,.77,;-4.55,.37,;-4.94,1.86,;-3.46,2.26,;-2.69,3.59,;-1.15,3.59,;3.61,3.08,;4.94,2.31,;3.61,4.62,;3.61,1.54,)|	InChI=1S/C20H18F3N3O2/c1-12-4-2-3-5-16(12)26-17-10-13(20(21,22)23)6-7-15(17)18(24-19(26)28)25-9-8-14(25)11-27/h2-7,10,14,27H,8-9,11H2,1H3	PUKDSWSPGMULNT-UHFFFAOYSA-N	508130	US11130759, Cpd. No. 440::US11046691, Compound 440::(R)-4-(2-(hydroxymethyl)azetidin-1- yl)-1-(o-tolyl)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 440	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508130&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148973805	459093209							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071984	Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1CC(CO)C1)C(F)(F)F |(2.28,-4.62,;3.61,-3.85,;4.94,-4.62,;6.28,-3.85,;6.28,-2.31,;4.94,-1.54,;3.61,-2.31,;2.28,-1.54,;2.28,,;3.61,.77,;3.61,2.31,;2.28,3.08,;.94,2.31,;.94,.77,;-.39,,;-.39,-1.54,;.94,-2.31,;.94,-3.85,;-1.72,.77,;-2.12,2.26,;-3.61,1.86,;-4.94,2.63,;-6.28,1.86,;-3.21,.37,;4.94,3.08,;6.28,2.31,;4.94,4.62,;4.94,1.54,)|	InChI=1S/C20H18F3N3O2/c1-12-4-2-3-5-16(12)26-17-8-14(20(21,22)23)6-7-15(17)18(24-19(26)28)25-9-13(10-25)11-27/h2-8,13,27H,9-11H2,1H3	HAEJCEYPKBPGQN-UHFFFAOYSA-N	508131	US11130759, Cpd. No. 441::US11046691, Compound 441::4-(3-(hydroxymethyl)azetidin-1-yl)-1- (o-tolyl)-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 441	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508131	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508131&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150383287	459093210							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071985	COC[C@H]1CCN1c1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F |r,wD:3.2,(-2.69,5.44,;-3.46,4.11,;-2.69,2.77,;-3.46,1.44,;-4.94,1.04,;-4.55,-.45,;-3.06,-.05,;-1.72,-.82,;-1.72,-2.36,;-.39,-3.13,;-.39,-4.67,;.94,-2.36,;2.28,-3.13,;3.61,-2.36,;4.94,-3.13,;4.94,-4.67,;3.61,-5.44,;2.28,-4.67,;.94,-5.44,;.94,-.82,;2.28,-.05,;2.28,1.49,;.94,2.26,;-.39,1.49,;-.39,-.05,;3.61,2.26,;4.94,1.49,;3.61,3.8,;3.61,.72,)|	InChI=1S/C21H20F3N3O2/c1-13-5-3-4-6-17(13)27-18-11-14(21(22,23)24)7-8-16(18)19(25-20(27)28)26-10-9-15(26)12-29-2/h3-8,11,15H,9-10,12H2,1-2H3	WWVBVIWSLYSNKT-UHFFFAOYSA-N	508132	US11130759, Cpd. No. 442::US11046691, Compound 442::(R)-4-(2-(methoxymethyl)azetidin-1- yl)-1-(o-tolyl)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 442	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508132	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508132&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152338013	459093211							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071986	Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1C[C@H](O)[C@@H](O)C1)C(F)(F)F |r,wU:20.23,wD:22.25,(1.98,-4.62,;3.32,-3.85,;4.65,-4.62,;5.99,-3.85,;5.99,-2.31,;4.65,-1.54,;3.32,-2.31,;1.98,-1.54,;1.98,,;3.32,.77,;3.32,2.31,;1.98,3.08,;.65,2.31,;.65,.77,;-.68,,;-.68,-1.54,;.65,-2.31,;.65,-3.85,;-2.02,.77,;-2.18,2.3,;-3.68,2.62,;-4.31,4.03,;-4.45,1.29,;-5.99,1.13,;-3.42,.14,;4.65,3.08,;5.99,2.31,;4.65,4.62,;4.65,1.54,)|	InChI=1S/C20H18F3N3O3/c1-11-4-2-3-5-14(11)26-15-8-12(20(21,22)23)6-7-13(15)18(24-19(26)29)25-9-16(27)17(28)10-25/h2-8,16-17,27-28H,9-10H2,1H3	RDQPHDLOAMUMEW-UHFFFAOYSA-N	508133	US11130759, Cpd. No. 443::US11046691, Compound 443::4-((3S,4S)-3,4-dihydroxypyrrolidin-1- yl)-1-(o-tolyl)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 443	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508133&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608227	459093212							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071987	Cc1ccccc1-n1c2cc(ccc2c(N[C@@H]2C[C@@H]2F)nc1=O)C(F)(F)F |r,wD:16.17,18.21,(2.1,-4.62,;3.44,-3.85,;4.77,-4.62,;6.1,-3.85,;6.1,-2.31,;4.77,-1.54,;3.44,-2.31,;2.1,-1.54,;2.1,,;3.44,.77,;3.44,2.31,;2.1,3.08,;.77,2.31,;.77,.77,;-.56,,;-1.9,.77,;-3.23,,;-4,-1.33,;-4.77,,;-6.1,.77,;-.56,-1.54,;.77,-2.31,;.77,-3.85,;4.77,3.08,;6.1,2.31,;4.77,4.62,;4.77,1.54,)|	InChI=1S/C19H15F4N3O/c1-10-4-2-3-5-15(10)26-16-8-11(19(21,22)23)6-7-12(16)17(25-18(26)27)24-14-9-13(14)20/h2-8,13-14H,9H2,1H3,(H,24,25,27)	MGRSEJLRHKXSNP-UHFFFAOYSA-N	508134	US11130759, Cpd. No. 444::US11046691, Compound 444::4-(((1R,2S)-2- fluorocyclopropyl)amino)-1-(o-tolyl)-7- (trifluoromethyl)-quinazolin-2(1H)-one::US11084798, Cpd No 444	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508134	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508134&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151063689	459093213							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071988	Cc1ccccc1-n1c2cc(ccc2c(N[C@H]2C[C@H]2F)nc1=O)C(F)(F)F |r,wU:16.17,18.21,(2.1,-4.62,;3.44,-3.85,;4.77,-4.62,;6.1,-3.85,;6.1,-2.31,;4.77,-1.54,;3.44,-2.31,;2.1,-1.54,;2.1,,;3.44,.77,;3.44,2.31,;2.1,3.08,;.77,2.31,;.77,.77,;-.56,,;-1.9,.77,;-3.23,,;-4,-1.33,;-4.77,,;-6.1,.77,;-.56,-1.54,;.77,-2.31,;.77,-3.85,;4.77,3.08,;6.1,2.31,;4.77,4.62,;4.77,1.54,)|	InChI=1S/C19H15F4N3O/c1-10-4-2-3-5-15(10)26-16-8-11(19(21,22)23)6-7-12(16)17(25-18(26)27)24-14-9-13(14)20/h2-8,13-14H,9H2,1H3,(H,24,25,27)	MGRSEJLRHKXSNP-UHFFFAOYSA-N	508135	US11130759, Cpd. No. 445::US11046691, Compound 445::4-(((1S,2R)-2- fluorocyclopropyl)amino)-1-(o-tolyl)-7- (trifluoromethyl)-quinazolin-2(1H)-one::US11084798, Cpd No 445	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508135	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508135&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151063688	459093214							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071989	Cc1ccccc1-n1c2cc(ccc2c(NCCCS(N)(=O)=O)nc1=O)C(F)(F)F |(3.33,-4.62,;4.67,-3.85,;6,-4.62,;7.34,-3.85,;7.34,-2.31,;6,-1.54,;4.67,-2.31,;3.33,-1.54,;3.33,,;4.67,.77,;4.67,2.31,;3.33,3.08,;2,2.31,;2,.77,;.67,,;-.67,.77,;-2,,;-3.33,.77,;-4.67,,;-6,.77,;-6,-.77,;-7.34,,;-6,2.31,;.67,-1.54,;2,-2.31,;2,-3.85,;6,3.08,;7.34,2.31,;6,4.62,;6,1.54,)|	InChI=1S/C19H19F3N4O3S/c1-12-5-2-3-6-15(12)26-16-11-13(19(20,21)22)7-8-14(16)17(25-18(26)27)24-9-4-10-30(23,28)29/h2-3,5-8,11H,4,9-10H2,1H3,(H2,23,28,29)(H,24,25,27)	IUCOOTLTFXKXIH-UHFFFAOYSA-N	508136	US11130759, Cpd. No. 446::US11046691, Compound 446::3-((2-oxo-1-(o-tolyl)-7-(trifluoro- methyl)-1,2-dihydroquinazolin-4-yl)- amino)propane-1-sulfonamide::US11084798, Cpd No 446	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508136	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508136&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608428	459093215							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071990	CNS(=O)(=O)CCCNc1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F |(-7.34,-1.54,;-6,-.77,;-6,.77,;-7.34,,;-6,2.31,;-4.67,,;-3.33,.77,;-2,,;-.67,.77,;.67,,;.67,-1.54,;2,-2.31,;2,-3.85,;3.33,-1.54,;4.67,-2.31,;6,-1.54,;7.34,-2.31,;7.34,-3.85,;6,-4.62,;4.67,-3.85,;3.33,-4.62,;3.33,,;4.67,.77,;4.67,2.31,;3.33,3.08,;2,2.31,;2,.77,;6,3.08,;7.34,2.31,;6,4.62,;6,1.54,)|	InChI=1S/C20H21F3N4O3S/c1-13-6-3-4-7-16(13)27-17-12-14(20(21,22)23)8-9-15(17)18(26-19(27)28)25-10-5-11-31(29,30)24-2/h3-4,6-9,12,24H,5,10-11H2,1-2H3,(H,25,26,28)	SCGBZPWPJUJHMJ-UHFFFAOYSA-N	508137	US11130759, Cpd. No. 447::US11046691, Compound 447::N-methyl-3-((2-oxo-1-(o-tolyl)-7- (trifluoromethyl)-1,2- dihydroquinazolin-4-yl)amino)propane- 1-sulfonamide::US11084798, Cpd No 447	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508137	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508137&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608629	459093216							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071991	Cc1ccccc1-n1c2cc(ccc2c(NCCS(N)(=O)=O)nc1=O)C(F)(F)F |(2.67,-4.62,;4,-3.85,;5.33,-4.62,;6.67,-3.85,;6.67,-2.31,;5.33,-1.54,;4,-2.31,;2.67,-1.54,;2.67,,;4,.77,;4,2.31,;2.67,3.08,;1.33,2.31,;1.33,.77,;;-1.33,.77,;-2.67,,;-4,.77,;-5.33,,;-5.33,-1.54,;-6.67,.77,;-5.33,1.54,;,-1.54,;1.33,-2.31,;1.33,-3.85,;5.33,3.08,;6.67,2.31,;5.33,4.62,;5.33,1.54,)|	InChI=1S/C18H17F3N4O3S/c1-11-4-2-3-5-14(11)25-15-10-12(18(19,20)21)6-7-13(15)16(24-17(25)26)23-8-9-29(22,27)28/h2-7,10H,8-9H2,1H3,(H2,22,27,28)(H,23,24,26)	XWWZUFASIUFVIQ-UHFFFAOYSA-N	508138	US11130759, Cpd. No. 448::US11046691, Compound 448::2-((2-oxo-1-(o-tolyl)-7-(trifluoro- methyl)-1,2-dihydroquinazolin-4-yl)- amino)ethane-1-sulfonamide::US11084798, Cpd No 448	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508138	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508138&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608873	459093217							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071992	CNS(=O)(=O)CCNc1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F |(-6.67,-2.31,;-5.33,-1.54,;-5.33,,;-6.67,.77,;-5.33,1.54,;-4,.77,;-2.67,,;-1.33,.77,;;,-1.54,;1.33,-2.31,;1.33,-3.85,;2.67,-1.54,;4,-2.31,;5.33,-1.54,;6.67,-2.31,;6.67,-3.85,;5.33,-4.62,;4,-3.85,;2.67,-4.62,;2.67,,;4,.77,;4,2.31,;2.67,3.08,;1.33,2.31,;1.33,.77,;5.33,3.08,;6.67,2.31,;5.33,4.62,;5.33,1.54,)|	InChI=1S/C19H19F3N4O3S/c1-12-5-3-4-6-15(12)26-16-11-13(19(20,21)22)7-8-14(16)17(25-18(26)27)24-9-10-30(28,29)23-2/h3-8,11,23H,9-10H2,1-2H3,(H,24,25,27)	RCZJCIBGSCMUKG-UHFFFAOYSA-N	508139	US11130759, Cpd. No. 449::US11046691, Compound 449::N-methyl-2-((2-oxo-1-(o-tolyl)-7- (trifluoromethyl)-1,2- dihydroquinazolin-4-yl)amino)ethane- 1-sulfonamide::US11084798, Cpd No 449	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508139	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508139&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			146714109	459093218							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071993	Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1CCO[C@H](CO)C1)C(F)(F)F |r,wD:22.25,(1.33,-5,;2.67,-4.23,;4,-5,;5.33,-4.23,;5.33,-2.69,;4,-1.93,;2.67,-2.69,;1.33,-1.93,;1.33,-.38,;2.67,.38,;2.67,1.93,;1.33,2.69,;,1.93,;,.38,;-1.33,-.38,;-1.33,-1.93,;,-2.69,;,-4.23,;-2.67,.38,;-4,-.38,;-5.33,.38,;-5.33,1.93,;-4,2.69,;-4,4.23,;-5.33,5,;-2.67,1.93,;4,2.69,;5.33,1.93,;4,4.23,;4,1.15,)|	InChI=1S/C21H20F3N3O3/c1-13-4-2-3-5-17(13)27-18-10-14(21(22,23)24)6-7-16(18)19(25-20(27)29)26-8-9-30-15(11-26)12-28/h2-7,10,15,28H,8-9,11-12H2,1H3	UQRPUWZOPICTHB-UHFFFAOYSA-N	508140	US11130759, Cpd. No. 450::US11046691, Compound 450::(S)-4-(2-(hydroxymethyl)morpholino)- 1-(o-tolyl)-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 450	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508140&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152051004	459093219							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071994	COC1CN(C1)c1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F |(-6.28,1.86,;-4.94,2.63,;-3.61,1.86,;-2.12,2.26,;-1.72,.77,;-3.21,.37,;-.39,,;-.39,-1.54,;.94,-2.31,;.94,-3.85,;2.28,-1.54,;3.61,-2.31,;4.94,-1.54,;6.28,-2.31,;6.28,-3.85,;4.94,-4.62,;3.61,-3.85,;2.28,-4.62,;2.28,,;3.61,.77,;3.61,2.31,;2.28,3.08,;.94,2.31,;.94,.77,;4.94,3.08,;6.28,2.31,;4.94,4.62,;4.94,1.54,)|	InChI=1S/C20H18F3N3O2/c1-12-5-3-4-6-16(12)26-17-9-13(20(21,22)23)7-8-15(17)18(24-19(26)27)25-10-14(11-25)28-2/h3-9,14H,10-11H2,1-2H3	UQWZOAAMISMOBO-UHFFFAOYSA-N	508141	US11130759, Cpd. No. 451::US11046691, Compound 451::4-(3-methoxyazetidin-1-yl)-1-(o-tolyl)- 7-(trifluoromethyl)quinazolin-2(1H)- one::US11084798, Cpd No 451	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508141&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152052029	459093220							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071995	CN1CCN(CC1=O)c1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F |(-6,3.08,;-4.67,2.31,;-4.67,.77,;-3.33,,;-2,.77,;-2,2.31,;-3.33,3.08,;-3.33,4.62,;-.67,,;-.67,-1.54,;.67,-2.31,;.67,-3.85,;2,-1.54,;3.33,-2.31,;4.67,-1.54,;6,-2.31,;6,-3.85,;4.67,-4.62,;3.33,-3.85,;2,-4.62,;2,,;3.33,.77,;3.33,2.31,;2,3.08,;.67,2.31,;.67,.77,;4.67,3.08,;6,2.31,;4.67,4.62,;4.67,1.54,)|	InChI=1S/C21H19F3N4O2/c1-13-5-3-4-6-16(13)28-17-11-14(21(22,23)24)7-8-15(17)19(25-20(28)30)27-10-9-26(2)18(29)12-27/h3-8,11H,9-10,12H2,1-2H3	YLODSTNCANYCLQ-UHFFFAOYSA-N	508142	US11130759, Cpd. No. 452::US11046691, Compound 452::(4-(4-methyl-3-oxopiperazin-1-yl)-1-(o- tolyl)-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 452	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508142&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152541101	459093221							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071996	Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1CC(O)C1)C(F)(F)F |(1.61,-4.62,;2.94,-3.85,;4.28,-4.62,;5.61,-3.85,;5.61,-2.31,;4.28,-1.54,;2.94,-2.31,;1.61,-1.54,;1.61,,;2.94,.77,;2.94,2.31,;1.61,3.08,;.28,2.31,;.28,.77,;-1.06,,;-1.06,-1.54,;.28,-2.31,;.28,-3.85,;-2.39,.77,;-2.79,2.26,;-4.28,1.86,;-5.61,2.63,;-3.88,.37,;4.28,3.08,;5.61,2.31,;4.28,4.62,;4.28,1.54,)|	InChI=1S/C19H16F3N3O2/c1-11-4-2-3-5-15(11)25-16-8-12(19(20,21)22)6-7-14(16)17(23-18(25)27)24-9-13(26)10-24/h2-8,13,26H,9-10H2,1H3	VNBABOYSYYAZPY-UHFFFAOYSA-N	508143	US11130759, Cpd. No. 453::US11046691, Compound 453::4-(3-hydroxyazetidin-1-yl)-1-(o-tolyl)- 7-(trifluoromethyl)quinazolin-2(1H)- one::US11084798, Cpd No 453	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508143&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152160254	459093222							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071997	Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1CC(C1)C#N)C(F)(F)F |(2.28,-4.62,;3.61,-3.85,;4.94,-4.62,;6.28,-3.85,;6.28,-2.31,;4.94,-1.54,;3.61,-2.31,;2.28,-1.54,;2.28,,;3.61,.77,;3.61,2.31,;2.28,3.08,;.94,2.31,;.94,.77,;-.39,,;-.39,-1.54,;.94,-2.31,;.94,-3.85,;-1.72,.77,;-2.12,2.26,;-3.61,1.86,;-3.21,.37,;-4.94,2.63,;-6.28,3.4,;4.94,3.08,;6.28,2.31,;4.94,4.62,;4.94,1.54,)|	InChI=1S/C20H15F3N4O/c1-12-4-2-3-5-16(12)27-17-8-14(20(21,22)23)6-7-15(17)18(25-19(27)28)26-10-13(9-24)11-26/h2-8,13H,10-11H2,1H3	LSLABMIVOSSYHM-UHFFFAOYSA-N	508144	US11130759, Cpd. No. 454::US11046691, Compound 454::1-(2-oxo-1-(o-tolyl)-7- (trifluoromethyl)-1,2- dihydroquinazolin-4-yl)azetidine-3- carbonitrile::US11084798, Cpd No 454	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508144&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608632	459093223							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071998	Cc1ccccc1-n1c2cc(ccc2c(NCCCNS(N)(=O)=O)nc1=O)C(F)(F)F |(4,-4.62,;5.33,-3.85,;6.67,-4.62,;8,-3.85,;8,-2.31,;6.67,-1.54,;5.33,-2.31,;4,-1.54,;4,,;5.33,.77,;5.33,2.31,;4,3.08,;2.67,2.31,;2.67,.77,;1.33,,;,.77,;-1.33,,;-2.67,.77,;-4,,;-5.33,.77,;-6.67,,;-8,.77,;-6.67,1.54,;-6.67,-1.54,;1.33,-1.54,;2.67,-2.31,;2.67,-3.85,;6.67,3.08,;8,2.31,;6.67,4.62,;6.67,1.54,)|	InChI=1S/C19H20F3N5O3S/c1-12-5-2-3-6-15(12)27-16-11-13(19(20,21)22)7-8-14(16)17(26-18(27)28)24-9-4-10-25-31(23,29)30/h2-3,5-8,11,25H,4,9-10H2,1H3,(H2,23,29,30)(H,24,26,28)	AVUBYUJXKIPJDA-UHFFFAOYSA-N	508145	US11130759, Cpd. No. 455::US11046691, Compound 455::amino(3-{[1-(2-methylphenyl)-2-oxo-7- (trifluoromethyl)hydroquinazolin-4-yl]- amino}propyl)sulfonamide::US11084798, Cpd No 455	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508145&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154929364	459093224							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1071999	Cc1ccccc1-n1c2cc(ccc2c(NCCNS(N)(=O)=O)nc1=O)C(F)(F)F |(3.33,-4.62,;4.67,-3.85,;6,-4.62,;7.34,-3.85,;7.34,-2.31,;6,-1.54,;4.67,-2.31,;3.33,-1.54,;3.33,,;4.67,.77,;4.67,2.31,;3.33,3.08,;2,2.31,;2,.77,;.67,,;-.67,.77,;-2,,;-3.33,.77,;-4.67,,;-6,.77,;-7.34,,;-6,-.77,;-6,2.31,;.67,-1.54,;2,-2.31,;2,-3.85,;6,3.08,;7.34,2.31,;6,4.62,;6,1.54,)|	InChI=1S/C18H18F3N5O3S/c1-11-4-2-3-5-14(11)26-15-10-12(18(19,20)21)6-7-13(15)16(25-17(26)27)23-8-9-24-30(22,28)29/h2-7,10,24H,8-9H2,1H3,(H2,22,28,29)(H,23,25,27)	ANLAZYXRKMUTNU-UHFFFAOYSA-N	508146	US11130759, Cpd. No. 456::US11046691, Compound 456::amino(2-{[1-(2-methylphenyl)-2-oxo-7- (trifluoromethyl)hydroquinazolin-4-yl]- amino}ethyl)sulfonamide::US11084798, Cpd No 456	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508146&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			146976377	459093225							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072000	NS(=O)(=O)CCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-6.1,-.67,;-6.1,.87,;-7.44,.1,;-6.1,2.41,;-4.77,.1,;-3.44,.87,;-2.1,.1,;-.77,.87,;.56,.1,;.56,-1.44,;1.9,-2.21,;1.9,-3.75,;3.23,-1.44,;4.56,-2.21,;5.9,-1.44,;7.23,-2.21,;7.23,-3.75,;5.9,-4.52,;4.56,-3.75,;3.23,-4.52,;3.23,.1,;4.56,.87,;4.56,2.41,;3.23,3.18,;1.9,2.41,;1.9,.87,;5.9,3.18,;7.44,3.18,;6.67,4.52,)|	InChI=1S/C20H21ClN4O3S/c21-16-4-1-2-5-17(16)25-18-12-14(13-6-7-13)8-9-15(18)19(24-20(25)26)23-10-3-11-29(22,27)28/h1-2,4-5,8-9,12-13H,3,6-7,10-11H2,(H2,22,27,28)(H,23,24,26)	IWDFDZWIWZXQOI-UHFFFAOYSA-N	508147	US11130759, Cpd. No. 457::US11046691, Compound 457::(3-((1-(2-chlorophenyl)-7-cyclopropyl- 2-oxo-1,2-dihydroquinazolin-4-yl)- amino)propane-1-sulfonamide::US11084798, Cpd No 457	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508147&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608350	459093226							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072001	CNS(=O)(=O)CCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-7.44,-1.44,;-6.1,-.67,;-6.1,.87,;-7.44,.1,;-6.1,2.41,;-4.77,.1,;-3.44,.87,;-2.1,.1,;-.77,.87,;.56,.1,;.56,-1.44,;1.9,-2.21,;1.9,-3.75,;3.23,-1.44,;4.56,-2.21,;5.9,-1.44,;7.23,-2.21,;7.23,-3.75,;5.9,-4.52,;4.56,-3.75,;3.23,-4.52,;3.23,.1,;4.56,.87,;4.56,2.41,;3.23,3.18,;1.9,2.41,;1.9,.87,;5.9,3.18,;7.44,3.18,;6.67,4.52,)|	InChI=1S/C21H23ClN4O3S/c1-23-30(28,29)12-4-11-24-20-16-10-9-15(14-7-8-14)13-19(16)26(21(27)25-20)18-6-3-2-5-17(18)22/h2-3,5-6,9-10,13-14,23H,4,7-8,11-12H2,1H3,(H,24,25,27)	PSFIYLPTJXNAMC-UHFFFAOYSA-N	508148	US11130759, Cpd. No. 458::US11046691, Compound 458::3-((1-(2-chlorophenyl)-7-cyclopropyl- 2-oxo-1,2-dihydroquinazolin-4- yl)amino)-N-methylpropane-1- sulfonamide::US11084798, Cpd No 458	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508148&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608620	459093227							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072002	NS(=O)(=O)CCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-5.44,-1.44,;-5.44,.1,;-6.77,.87,;-5.44,1.64,;-4.1,.87,;-2.77,.1,;-1.44,.87,;-.1,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-1.44,;3.9,-2.21,;5.23,-1.44,;6.57,-2.21,;6.57,-3.75,;5.23,-4.52,;3.9,-3.75,;2.56,-4.52,;2.56,.1,;3.9,.87,;3.9,2.41,;2.56,3.18,;1.23,2.41,;1.23,.87,;5.23,3.18,;6.77,3.18,;6,4.52,)|	InChI=1S/C19H19ClN4O3S/c20-15-3-1-2-4-16(15)24-17-11-13(12-5-6-12)7-8-14(17)18(23-19(24)25)22-9-10-28(21,26)27/h1-4,7-8,11-12H,5-6,9-10H2,(H2,21,26,27)(H,22,23,25)	PDZQPSIOXRDUMH-UHFFFAOYSA-N	508149	US11130759, Cpd. No. 459::US11046691, Compound 459::2-((1-(2-chlorophenyl)-7-cyclopropyl- 2-oxo-1,2-dihydroquinazolin-4-yl)- amino)ethane-1-sulfonamide::US11084798, Cpd No 459	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508149&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608808	459093228							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072003	CNS(=O)(=O)CCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-6.77,-2.21,;-5.44,-1.44,;-5.44,.1,;-6.77,.87,;-5.44,1.64,;-4.1,.87,;-2.77,.1,;-1.44,.87,;-.1,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-1.44,;3.9,-2.21,;5.23,-1.44,;6.57,-2.21,;6.57,-3.75,;5.23,-4.52,;3.9,-3.75,;2.56,-4.52,;2.56,.1,;3.9,.87,;3.9,2.41,;2.56,3.18,;1.23,2.41,;1.23,.87,;5.23,3.18,;6.77,3.18,;6,4.52,)|	InChI=1S/C20H21ClN4O3S/c1-22-29(27,28)11-10-23-19-15-9-8-14(13-6-7-13)12-18(15)25(20(26)24-19)17-5-3-2-4-16(17)21/h2-5,8-9,12-13,22H,6-7,10-11H2,1H3,(H,23,24,26)	GIWJTYFMJIBJPH-UHFFFAOYSA-N	508150	US11130759, Cpd. No. 460::US11046691, Compound 460::2-((1-(2-chlorophenyl)-7-cyclopropyl- 2-oxo-1,2-dihydroquinazolin-4- yl)amino)-N-methylethane-1- sulfonamide::US11084798, Cpd No 460	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508150	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508150&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608722	459093229							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072004	OCC1CCN(CC1)c1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-6.77,2.41,;-5.44,3.18,;-4.1,2.41,;-2.77,3.18,;-1.44,2.41,;-1.44,.87,;-2.77,.1,;-4.1,.87,;-.1,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-1.44,;3.9,-2.21,;5.23,-1.44,;6.57,-2.21,;6.57,-3.75,;5.23,-4.52,;3.9,-3.75,;2.56,-4.52,;2.56,.1,;3.9,.87,;3.9,2.41,;2.56,3.18,;1.23,2.41,;1.23,.87,;5.23,3.18,;6.77,3.18,;6,4.52,)|	InChI=1S/C23H24ClN3O2/c24-19-3-1-2-4-20(19)27-21-13-17(16-5-6-16)7-8-18(21)22(25-23(27)29)26-11-9-15(14-28)10-12-26/h1-4,7-8,13,15-16,28H,5-6,9-12,14H2	HWOODKBOTGCRNS-UHFFFAOYSA-N	508151	US11130759, Cpd. No. 461::US11046691, Compound 461::1-(2-chlorophenyl)-7-cyclopropyl-4-(4- (hydroxymethyl)piperidin-1-yl)- quinazolin-2(1H)-one::US11084798, Cpd No 461	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508151&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608820	459093230							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072005	OC1CCCN(C1)c1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |w:1.0,(-4.1,4.62,;-4.1,3.08,;-5.44,2.31,;-5.44,.77,;-4.1,,;-2.77,.77,;-2.77,2.31,;-1.44,,;-1.44,-1.54,;-.1,-2.31,;-.1,-3.85,;1.23,-1.54,;2.56,-2.31,;3.9,-1.54,;5.23,-2.31,;5.23,-3.85,;3.9,-4.62,;2.56,-3.85,;1.23,-4.62,;1.23,,;2.56,.77,;2.56,2.31,;1.23,3.08,;-.1,2.31,;-.1,.77,;3.9,3.08,;5.44,3.08,;4.67,4.41,)|	InChI=1S/C22H22ClN3O2/c23-18-5-1-2-6-19(18)26-20-12-15(14-7-8-14)9-10-17(20)21(24-22(26)28)25-11-3-4-16(27)13-25/h1-2,5-6,9-10,12,14,16,27H,3-4,7-8,11,13H2	ACDGKNSZKQLIQY-UHFFFAOYSA-N	508152	US11130759, Cpd. No. 462::US11046691, Compound 462::1-(2-chlorophenyl)-7-cyclopropyl-4-(3- hydroxypiperidin-1-yl)quinazolin- 2(1H)-one::US11084798, Cpd No 462	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508152	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508152&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154929290	459093231							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072006	OC1CN(C1)c1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-5.71,2.73,;-4.38,1.96,;-2.89,2.36,;-2.49,.87,;-3.98,.47,;-1.16,.1,;-1.16,-1.44,;.17,-2.21,;.17,-3.75,;1.51,-1.44,;2.84,-2.21,;4.17,-1.44,;5.51,-2.21,;5.51,-3.75,;4.17,-4.52,;2.84,-3.75,;1.51,-4.52,;1.51,.1,;2.84,.87,;2.84,2.41,;1.51,3.18,;.17,2.41,;.17,.87,;4.17,3.18,;5.71,3.18,;4.94,4.52,)|	InChI=1S/C20H18ClN3O2/c21-16-3-1-2-4-17(16)24-18-9-13(12-5-6-12)7-8-15(18)19(22-20(24)26)23-10-14(25)11-23/h1-4,7-9,12,14,25H,5-6,10-11H2	FFEBPDISQCHVJG-UHFFFAOYSA-N	508153	US11130759, Cpd. No. 463::US11046691, Compound 463::1-(2-chlorophenyl)-7-cyclopropyl-4-(3- hydroxyazetidin-1-yl)quinazolin-2(1H)- one::US11084798, Cpd No 463	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508153	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508153&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608867	459093232							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072007	NS(=O)(=O)NCCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-8.11,.87,;-6.77,.1,;-6.77,-1.44,;-6.77,1.64,;-5.44,.87,;-4.1,.1,;-2.77,.87,;-1.44,.1,;-.1,.87,;1.23,.1,;1.23,-1.44,;2.56,-2.21,;2.56,-3.75,;3.9,-1.44,;5.23,-2.21,;6.57,-1.44,;7.9,-2.21,;7.9,-3.75,;6.57,-4.52,;5.23,-3.75,;3.9,-4.52,;3.9,.1,;5.23,.87,;5.23,2.41,;3.9,3.18,;2.56,2.41,;2.56,.87,;6.57,3.18,;8.11,3.18,;7.34,4.52,)|	InChI=1S/C20H22ClN5O3S/c21-16-4-1-2-5-17(16)26-18-12-14(13-6-7-13)8-9-15(18)19(25-20(26)27)23-10-3-11-24-30(22,28)29/h1-2,4-5,8-9,12-13,24H,3,6-7,10-11H2,(H2,22,28,29)(H,23,25,27)	PYABXSOYVJCIKZ-UHFFFAOYSA-N	508154	US11130759, Cpd. No. 464::US11046691, Compound 464::(3-{[1-(2-chlorophenyl)-7-cyclopropyl- 2-oxohydroquinazolin-4-yl]amino}- propyl)sulfonamide::US11084798, Cpd No 464	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508154&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148992726	459093233							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072008	NS(=O)(=O)NCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-7.44,.1,;-6.1,.87,;-6.1,-.67,;-6.1,2.41,;-4.77,.1,;-3.44,.87,;-2.1,.1,;-.77,.87,;.56,.1,;.56,-1.44,;1.9,-2.21,;1.9,-3.75,;3.23,-1.44,;4.56,-2.21,;5.9,-1.44,;7.23,-2.21,;7.23,-3.75,;5.9,-4.52,;4.56,-3.75,;3.23,-4.52,;3.23,.1,;4.56,.87,;4.56,2.41,;3.23,3.18,;1.9,2.41,;1.9,.87,;5.9,3.18,;7.44,3.18,;6.67,4.52,)|	InChI=1S/C19H20ClN5O3S/c20-15-3-1-2-4-16(15)25-17-11-13(12-5-6-12)7-8-14(17)18(24-19(25)26)22-9-10-23-29(21,27)28/h1-4,7-8,11-12,23H,5-6,9-10H2,(H2,21,27,28)(H,22,24,26)	LIVQNYIAKHWAJL-UHFFFAOYSA-N	508155	US11130759, Cpd. No. 465::US11046691, Compound 465::(2-{[1-(2-chlorophenyl)-7-cyclopropyl- 2-oxohydroquinazolin-4-yl]amino}- ethyl)sulfonamide::US11084798, Cpd No 465	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508155	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508155&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933675	459093234							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072009	FC(F)c1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)ccn1 |(-3.44,-4.52,;-4.77,-3.75,;-6.1,-4.52,;-4.77,-2.21,;-3.44,-1.44,;-3.44,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;4.56,-1.44,;5.9,-2.21,;5.9,-3.75,;4.56,-4.52,;3.23,-3.75,;1.9,-4.52,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,;-4.77,.87,;-6.1,.1,;-6.1,-1.44,)|	InChI=1S/C23H17ClF2N4O/c24-17-3-1-2-4-19(17)30-20-11-14(13-5-6-13)7-8-16(20)22(29-23(30)31)28-15-9-10-27-18(12-15)21(25)26/h1-4,7-13,21H,5-6H2,(H,27,28,29,31)	MFMSERDUVVUZCH-UHFFFAOYSA-N	508156	US11130759, Cpd. No. 466::US11046691, Compound 466::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-(difluoromethyl)pyridin-4- yl)amino)-quinazolin-2(1H)-one::US11084798, Cpd No 466	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508156	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508156&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608496	459093235							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072010	Clc1ccccc1-n1c2cc(ccc2c(Nc2ccnc(c2)C2CC2)nc1=O)C1CC1 |(1.9,-4.24,;3.23,-3.47,;4.56,-4.24,;5.9,-3.47,;5.9,-1.93,;4.56,-1.16,;3.23,-1.93,;1.9,-1.16,;1.9,.38,;3.23,1.15,;3.23,2.69,;1.9,3.46,;.56,2.69,;.56,1.15,;-.77,.38,;-2.1,1.15,;-3.44,.38,;-4.77,1.15,;-6.1,.38,;-6.1,-1.15,;-4.77,-1.92,;-3.44,-1.15,;-4.77,-3.46,;-5.54,-4.8,;-4,-4.8,;-.77,-1.16,;.56,-1.93,;.56,-3.47,;4.56,3.46,;6.1,3.46,;5.33,4.8,)|	InChI=1S/C25H21ClN4O/c26-20-3-1-2-4-22(20)30-23-13-17(15-5-6-15)9-10-19(23)24(29-25(30)31)28-18-11-12-27-21(14-18)16-7-8-16/h1-4,9-16H,5-8H2,(H,27,28,29,31)	FDRSOUSSKLPXBT-UHFFFAOYSA-N	508157	US11130759, Cpd. No. 467::US11046691, Compound 467::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-cyclopropylpyridin-4-yl)amino)- quinazolin-2(1H)-one::US11084798, Cpd No 467	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508157	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508157&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147481302	459093236							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072011	FC(F)Oc1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)ccn1 |(-6.77,-2.98,;-5.44,-3.75,;-5.44,-5.29,;-4.1,-2.98,;-4.1,-1.44,;-2.77,-.67,;-2.77,.87,;-1.44,1.64,;-.1,.87,;-.1,-.67,;1.23,-1.44,;1.23,-2.98,;2.56,-.67,;3.9,-1.44,;5.23,-.67,;6.57,-1.44,;6.57,-2.98,;5.23,-3.75,;3.9,-2.98,;2.56,-3.75,;2.56,.87,;3.9,1.64,;3.9,3.18,;2.56,3.95,;1.23,3.18,;1.23,1.64,;5.23,3.95,;6.77,3.95,;6,5.29,;-4.1,1.64,;-5.44,.87,;-5.44,-.67,)|	InChI=1S/C23H17ClF2N4O2/c24-17-3-1-2-4-18(17)30-19-11-14(13-5-6-13)7-8-16(19)21(29-23(30)31)28-15-9-10-27-20(12-15)32-22(25)26/h1-4,7-13,22H,5-6H2,(H,27,28,29,31)	OJVGHEWUGFCEGH-UHFFFAOYSA-N	508158	US11130759, Cpd. No. 468::US11046691, Compound 468::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-(difluoromethoxy)pyridin-4- yl)amino)-quinazolin-2(1H)-one::US11084798, Cpd No 468	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508158&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608256	459093237							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072012	Cc1noc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)n1 |(-5.45,-3.4,;-5.05,-1.91,;-5.96,-.67,;-5.05,.58,;-3.59,.1,;-2.25,.87,;-.92,.1,;-.92,-1.44,;.41,-2.21,;.41,-3.75,;1.75,-1.44,;3.08,-2.21,;4.42,-1.44,;5.75,-2.21,;5.75,-3.75,;4.42,-4.52,;3.08,-3.75,;1.75,-4.52,;1.75,.1,;3.08,.87,;3.08,2.41,;1.75,3.18,;.41,2.41,;.41,.87,;4.42,3.18,;5.96,3.18,;5.19,4.52,;-3.59,-1.44,)|	InChI=1S/C20H16ClN5O2/c1-11-22-19(28-25-11)23-18-14-9-8-13(12-6-7-12)10-17(14)26(20(27)24-18)16-5-3-2-4-15(16)21/h2-5,8-10,12H,6-7H2,1H3,(H,22,23,24,25,27)	AKCFNTDDTKIOAI-UHFFFAOYSA-N	508159	US11130759, Cpd. No. 469::US11046691, Compound 469::1-(2-chlorophenyl)-7-cyclopropyl-4- ((3-methyl-1,2,4-oxadiazol-5- yl)amino)-quinazolin-2(1H)-one::US11084798, Cpd No 469	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508159	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508159&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608439	459093238							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072013	Clc1ccccc1-n1c2cc(ccc2c(NCc2cnco2)nc1=O)C1CC1 |(2.42,-4.52,;3.75,-3.75,;5.08,-4.52,;6.42,-3.75,;6.42,-2.21,;5.08,-1.44,;3.75,-2.21,;2.42,-1.44,;2.42,.1,;3.75,.87,;3.75,2.41,;2.42,3.18,;1.08,2.41,;1.08,.87,;-.25,.1,;-1.59,.87,;-2.92,.1,;-4.25,.87,;-4.25,2.41,;-5.72,2.89,;-6.62,1.64,;-5.72,.4,;-.25,-1.44,;1.08,-2.21,;1.08,-3.75,;5.08,3.18,;6.62,3.18,;5.85,4.52,)|	InChI=1S/C21H17ClN4O2/c22-17-3-1-2-4-18(17)26-19-9-14(13-5-6-13)7-8-16(19)20(25-21(26)27)24-11-15-10-23-12-28-15/h1-4,7-10,12-13H,5-6,11H2,(H,24,25,27)	YLVOTIMBIUFBAR-UHFFFAOYSA-N	508160	US11130759, Cpd. No. 470::US11046691, Compound 470::1-(2-chlorophenyl)-7-cyclopropyl-4- ((oxazol-5-ylmethyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 470	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508160	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508160&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149382054	459093239							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072014	Clc1ccccc1-n1c2cc(ccc2c(NCc2ccon2)nc1=O)C1CC1 |(2.42,-4.52,;3.75,-3.75,;5.08,-4.52,;6.42,-3.75,;6.42,-2.21,;5.08,-1.44,;3.75,-2.21,;2.42,-1.44,;2.42,.1,;3.75,.87,;3.75,2.41,;2.42,3.18,;1.08,2.41,;1.08,.87,;-.25,.1,;-1.59,.87,;-2.92,.1,;-4.25,.87,;-4.25,2.41,;-5.72,2.89,;-6.62,1.64,;-5.72,.4,;-.25,-1.44,;1.08,-2.21,;1.08,-3.75,;5.08,3.18,;6.62,3.18,;5.85,4.52,)|	InChI=1S/C21H17ClN4O2/c22-17-3-1-2-4-18(17)26-19-11-14(13-5-6-13)7-8-16(19)20(24-21(26)27)23-12-15-9-10-28-25-15/h1-4,7-11,13H,5-6,12H2,(H,23,24,27)	QUARFCVOTTVIBQ-UHFFFAOYSA-N	508161	US11130759, Cpd. No. 471::US11046691, Compound 471::1-(2-chlorophenyl)-7-cyclopropyl-4- ((isoxazol-3- ylmethyl)amino)quinazolin-2(1H)-one::US11084798, Cpd No 471	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508161&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608280	459093240							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072015	Cc1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)no1 |(-6.7,-.27,;-5.21,-.67,;-4.31,.58,;-2.84,.1,;-1.51,.87,;-.18,.1,;-.18,-1.44,;1.16,-2.21,;1.16,-3.75,;2.49,-1.44,;3.83,-2.21,;5.16,-1.44,;6.49,-2.21,;6.49,-3.75,;5.16,-4.52,;3.83,-3.75,;2.49,-4.52,;2.49,.1,;3.83,.87,;3.83,2.41,;2.49,3.18,;1.16,2.41,;1.16,.87,;5.16,3.18,;6.7,3.18,;5.93,4.52,;-2.84,-1.44,;-4.31,-1.91,)|	InChI=1S/C21H17ClN4O2/c1-12-10-19(25-28-12)23-20-15-9-8-14(13-6-7-13)11-18(15)26(21(27)24-20)17-5-3-2-4-16(17)22/h2-5,8-11,13H,6-7H2,1H3,(H,23,24,25,27)	NASSOWRVBRMREO-UHFFFAOYSA-N	508162	US11130759, Cpd. No. 472::US11046691, Compound 472::1-(2-chlorophenyl)-7-cyclopropyl-4- ((5-methylisoxazol-3- yl)amino)quinazolin-2(1H)-one::US11084798, Cpd No 472	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508162&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608954	459093241							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072016	Cn1cc(CNc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)cn1 |(-7.39,1.64,;-5.85,1.64,;-4.95,.4,;-3.48,.87,;-2.15,.1,;-.82,.87,;.52,.1,;.52,-1.44,;1.85,-2.21,;1.85,-3.75,;3.19,-1.44,;4.52,-2.21,;5.85,-1.44,;7.19,-2.21,;7.19,-3.75,;5.85,-4.52,;4.52,-3.75,;3.19,-4.52,;3.19,.1,;4.52,.87,;4.52,2.41,;3.19,3.18,;1.85,2.41,;1.85,.87,;5.85,3.18,;7.39,3.18,;6.62,4.52,;-3.48,2.41,;-4.95,2.89,)|	InChI=1S/C22H20ClN5O/c1-27-13-14(12-25-27)11-24-21-17-9-8-16(15-6-7-15)10-20(17)28(22(29)26-21)19-5-3-2-4-18(19)23/h2-5,8-10,12-13,15H,6-7,11H2,1H3,(H,24,26,29)	CCTPXLFDIISOLD-UHFFFAOYSA-N	508163	US11130759, Cpd. No. 473::US11046691, Compound 473::1-(2-chlorophenyl)-7-cyclopropyl-4- (((1-methyl-1H-pyrazol-4- yl)methyl)amino)-quinazolin-2(1H)-one::US11084798, Cpd No 473	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508163&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608964	459093242							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072017	Clc1ccccc1-n1c2cc(ccc2c(Nc2ccon2)nc1=O)C1CC1 |(1.75,-4.52,;3.08,-3.75,;4.42,-4.52,;5.75,-3.75,;5.75,-2.21,;4.42,-1.44,;3.08,-2.21,;1.75,-1.44,;1.75,.1,;3.08,.87,;3.08,2.41,;1.75,3.18,;.41,2.41,;.41,.87,;-.92,.1,;-2.25,.87,;-3.59,.1,;-3.59,-1.44,;-5.05,-1.91,;-5.96,-.67,;-5.05,.58,;-.92,-1.44,;.41,-2.21,;.41,-3.75,;4.42,3.18,;5.96,3.18,;5.19,4.52,)|	InChI=1S/C20H15ClN4O2/c21-15-3-1-2-4-16(15)25-17-11-13(12-5-6-12)7-8-14(17)19(23-20(25)26)22-18-9-10-27-24-18/h1-4,7-12H,5-6H2,(H,22,23,24,26)	FOVCUYVPQBGBSF-UHFFFAOYSA-N	508164	US11130759, Cpd. No. 474::US11046691, Compound 474::1-(2-chlorophenyl)-7-cyclopropyl-4- (isoxazol-3-ylamino)quinazolin-2(1H)- one::US11084798, Cpd No 474	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508164&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608858	459093243							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072018	COc1cncc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)c1 |(-6.1,-4.52,;-4.77,-3.75,;-4.77,-2.21,;-6.1,-1.44,;-6.1,.1,;-4.77,.87,;-3.44,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;4.56,-1.44,;5.9,-2.21,;5.9,-3.75,;4.56,-4.52,;3.23,-3.75,;1.9,-4.52,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,;-3.44,-1.44,)|	InChI=1S/C23H19ClN4O2/c1-30-17-11-16(12-25-13-17)26-22-18-9-8-15(14-6-7-14)10-21(18)28(23(29)27-22)20-5-3-2-4-19(20)24/h2-5,8-14H,6-7H2,1H3,(H,26,27,29)	DISQXKKAPANPTH-UHFFFAOYSA-N	508165	US11130759, Cpd. No. 475::US11046691, Compound 475::1-(2-chlorophenyl)-7-cyclopropyl-4- ((5-methoxypyridin-3- yl)amino)quinazolin-2(1H)-one::US11084798, Cpd No 475	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508165&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608659	459093244							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072019	Cc1ccc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)cn1 |(-6.77,-2.21,;-5.44,-1.44,;-5.44,.1,;-4.1,.87,;-2.77,.1,;-1.44,.87,;-.1,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-1.44,;3.9,-2.21,;5.23,-1.44,;6.57,-2.21,;6.57,-3.75,;5.23,-4.52,;3.9,-3.75,;2.56,-4.52,;2.56,.1,;3.9,.87,;3.9,2.41,;2.56,3.18,;1.23,2.41,;1.23,.87,;5.23,3.18,;6.77,3.18,;6,4.52,;-2.77,-1.44,;-4.1,-2.21,)|	InChI=1S/C23H19ClN4O/c1-14-6-10-17(13-25-14)26-22-18-11-9-16(15-7-8-15)12-21(18)28(23(29)27-22)20-5-3-2-4-19(20)24/h2-6,9-13,15H,7-8H2,1H3,(H,26,27,29)	OTBQARDCTGYTIS-UHFFFAOYSA-N	508166	US11130759, Cpd. No. 476::US11046691, Compound 476::1-(2-chlorophenyl)-7-cyclopropyl-4- ((6-methylpyridin-3- yl)amino)quinazolin-2(1H)-one::US11084798, Cpd No 476	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508166&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608614	459093245							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072020	COc1ccc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)cn1 |(-7.44,-1.44,;-6.1,-2.21,;-4.77,-1.44,;-4.77,.1,;-3.44,.87,;-2.1,.1,;-.77,.87,;.56,.1,;.56,-1.44,;1.9,-2.21,;1.9,-3.75,;3.23,-1.44,;4.56,-2.21,;5.9,-1.44,;7.23,-2.21,;7.23,-3.75,;5.9,-4.52,;4.56,-3.75,;3.23,-4.52,;3.23,.1,;4.56,.87,;4.56,2.41,;3.23,3.18,;1.9,2.41,;1.9,.87,;5.9,3.18,;7.44,3.18,;6.67,4.52,;-2.1,-1.44,;-3.44,-2.21,)|	InChI=1S/C23H19ClN4O2/c1-30-21-11-9-16(13-25-21)26-22-17-10-8-15(14-6-7-14)12-20(17)28(23(29)27-22)19-5-3-2-4-18(19)24/h2-5,8-14H,6-7H2,1H3,(H,26,27,29)	GEIRBWZNZWEWMY-UHFFFAOYSA-N	508167	US11130759, Cpd. No. 477::US11046691, Compound 477::1-(2-chlorophenyl)-7-cyclopropyl-4- ((6-methoxypyridin-3- yl)amino)quinazolin-2(1H)-one::US11084798, Cpd No 477	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508167&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147623602	459093246							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072021	Clc1ccccc1-n1c2cc(ccc2c(NCc2ccncc2)nc1=O)C1CC1 |(2.56,-4.52,;3.9,-3.75,;5.23,-4.52,;6.57,-3.75,;6.57,-2.21,;5.23,-1.44,;3.9,-2.21,;2.56,-1.44,;2.56,.1,;3.9,.87,;3.9,2.41,;2.56,3.18,;1.23,2.41,;1.23,.87,;-.1,.1,;-1.44,.87,;-2.77,.1,;-4.1,.87,;-4.1,2.41,;-5.44,3.18,;-6.77,2.41,;-6.77,.87,;-5.44,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;5.23,3.18,;6.77,3.18,;6,4.52,)|	InChI=1S/C23H19ClN4O/c24-19-3-1-2-4-20(19)28-21-13-17(16-5-6-16)7-8-18(21)22(27-23(28)29)26-14-15-9-11-25-12-10-15/h1-4,7-13,16H,5-6,14H2,(H,26,27,29)	STEVTCABTRZDKX-UHFFFAOYSA-N	508168	US11130759, Cpd. No. 478::US11046691, Compound 478::1-(2-chlorophenyl)-7-cyclopropyl-4- ((pyridin-4-ylmethyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 478	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508168&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608430	459093247							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072022	Clc1ccccc1-n1c2cc(ccc2c(NCc2cccnc2)nc1=O)C1CC1 |(2.56,-4.52,;3.9,-3.75,;5.23,-4.52,;6.57,-3.75,;6.57,-2.21,;5.23,-1.44,;3.9,-2.21,;2.56,-1.44,;2.56,.1,;3.9,.87,;3.9,2.41,;2.56,3.18,;1.23,2.41,;1.23,.87,;-.1,.1,;-1.44,.87,;-2.77,.1,;-4.1,.87,;-4.1,2.41,;-5.44,3.18,;-6.77,2.41,;-6.77,.87,;-5.44,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;5.23,3.18,;6.77,3.18,;6,4.52,)|	InChI=1S/C23H19ClN4O/c24-19-5-1-2-6-20(19)28-21-12-17(16-7-8-16)9-10-18(21)22(27-23(28)29)26-14-15-4-3-11-25-13-15/h1-6,9-13,16H,7-8,14H2,(H,26,27,29)	BRKLEPIVMYSWBF-UHFFFAOYSA-N	508169	US11130759, Cpd. No. 479::US11046691, Compound 479::1-(2-chlorophenyl)-7-cyclopropyl-4- ((pyridin-3-ylmethyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 479	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508169&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147137291	459093248							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072023	Clc1ccccc1-n1c2cc(ccc2c(NCc2ccccn2)nc1=O)C1CC1 |(2.56,-4.52,;3.9,-3.75,;5.23,-4.52,;6.57,-3.75,;6.57,-2.21,;5.23,-1.44,;3.9,-2.21,;2.56,-1.44,;2.56,.1,;3.9,.87,;3.9,2.41,;2.56,3.18,;1.23,2.41,;1.23,.87,;-.1,.1,;-1.44,.87,;-2.77,.1,;-4.1,.87,;-4.1,2.41,;-5.44,3.18,;-6.77,2.41,;-6.77,.87,;-5.44,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;5.23,3.18,;6.77,3.18,;6,4.52,)|	InChI=1S/C23H19ClN4O/c24-19-6-1-2-7-20(19)28-21-13-16(15-8-9-15)10-11-18(21)22(27-23(28)29)26-14-17-5-3-4-12-25-17/h1-7,10-13,15H,8-9,14H2,(H,26,27,29)	TYESQFPJTMYUBI-UHFFFAOYSA-N	508170	US11130759, Cpd. No. 480::US11046691, Compound 480::1-(2-chlorophenyl)-7-cyclopropyl-4- ((pyridin-2-ylmethyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 480	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508170&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608433	459093249							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072024	CNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(C)C |(-4.67,,;-3.33,.77,;-2,,;-2,-1.54,;-.67,-2.31,;-.67,-3.85,;.67,-1.54,;2,-2.31,;3.33,-1.54,;4.67,-2.31,;4.67,-3.85,;3.33,-4.62,;2,-3.85,;.67,-4.62,;.67,,;2,.77,;2,2.31,;.67,3.08,;-.67,2.31,;-.67,.77,;3.33,3.08,;4.67,2.31,;3.33,4.62,)|	InChI=1S/C17H17ClN4O/c1-10(2)13-9-8-11-15(19-3)21-17(23)22(16(11)20-13)14-7-5-4-6-12(14)18/h4-10H,1-3H3,(H,19,21,23)	LUOKCZVHDPPWOW-UHFFFAOYSA-N	508171	US11130759, Cpd. No. 481::US11046691, Compound 481::1-(2-chlorophenyl)-7-isopropyl-4- (methylamino)pyrido[2,3-d]pyrimidin- 2(1H)-one::US11084798, Cpd No 481	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508171	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508171&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609042	459093250							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072025	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)F |(-4.67,,;-3.33,.77,;-2,,;-2,-1.54,;-.67,-2.31,;-.67,-3.85,;.67,-1.54,;2,-2.31,;3.33,-1.54,;4.67,-2.31,;4.67,-3.85,;3.33,-4.62,;2,-3.85,;.67,-4.62,;.67,,;2,.77,;2,2.31,;.67,3.08,;-.67,2.31,;-.67,.77,;3.33,3.08,;4.67,2.31,;3.33,4.62,)|	InChI=1S/C16H12ClF2N3O/c1-20-15-10-7-6-9(14(18)19)8-13(10)22(16(23)21-15)12-5-3-2-4-11(12)17/h2-8,14H,1H3,(H,20,21,23)	AWCWYSBLFLUMEX-UHFFFAOYSA-N	508172	US11130759, Cpd. No. 482::US11046691, Compound 482::1-(2-chlorophenyl)-7-(difluoromethyl)- 4-(methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 482	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508172&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608517	459093251							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072026	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(C)C |(-4.67,,;-3.33,.77,;-2,,;-2,-1.54,;-.67,-2.31,;-.67,-3.85,;.67,-1.54,;2,-2.31,;3.33,-1.54,;4.67,-2.31,;4.67,-3.85,;3.33,-4.62,;2,-3.85,;.67,-4.62,;.67,,;2,.77,;2,2.31,;.67,3.08,;-.67,2.31,;-.67,.77,;3.33,3.08,;4.67,2.31,;3.33,4.62,)|	InChI=1S/C18H18ClN3O/c1-11(2)12-8-9-13-16(10-12)22(18(23)21-17(13)20-3)15-7-5-4-6-14(15)19/h4-11H,1-3H3,(H,20,21,23)	CZSHRQOOXJUYBP-UHFFFAOYSA-N	508173	US11130759, Cpd. No. 483::US11046691, Compound 483::1-(2-chlorophenyl)-7-isopropyl-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 483	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508173	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508173&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147320576	459093252							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072027	Clc1ccccc1-n1c2cc(ccc2c(Nc2cncnc2)nc1=O)C1CC1 |(1.9,-4.52,;3.23,-3.75,;4.56,-4.52,;5.9,-3.75,;5.9,-2.21,;4.56,-1.44,;3.23,-2.21,;1.9,-1.44,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;-.77,.1,;-2.1,.87,;-3.44,.1,;-4.77,.87,;-6.1,.1,;-6.1,-1.44,;-4.77,-2.21,;-3.44,-1.44,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;4.56,3.18,;6.1,3.18,;5.33,4.52,)|	InChI=1S/C21H16ClN5O/c22-17-3-1-2-4-18(17)27-19-9-14(13-5-6-13)7-8-16(19)20(26-21(27)28)25-15-10-23-12-24-11-15/h1-4,7-13H,5-6H2,(H,25,26,28)	MWNLWRYCTGMBIT-UHFFFAOYSA-N	508174	US11130759, Cpd. No. 484::US11046691, Compound 484::1-(2-chlorophenyl)-7-cyclopropyl-4- (pyrimidin-5-ylamino)quinazolin- 2(1H)-one::US11084798, Cpd No 484	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508174&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608557	459093253							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072028	Clc1ccccc1-n1c2cc(ccc2c(Nc2cccnc2)nc1=O)C1CC1 |(1.9,-4.52,;3.23,-3.75,;4.56,-4.52,;5.9,-3.75,;5.9,-2.21,;4.56,-1.44,;3.23,-2.21,;1.9,-1.44,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;-.77,.1,;-2.1,.87,;-3.44,.1,;-4.77,.87,;-6.1,.1,;-6.1,-1.44,;-4.77,-2.21,;-3.44,-1.44,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;4.56,3.18,;6.1,3.18,;5.33,4.52,)|	InChI=1S/C22H17ClN4O/c23-18-5-1-2-6-19(18)27-20-12-15(14-7-8-14)9-10-17(20)21(26-22(27)28)25-16-4-3-11-24-13-16/h1-6,9-14H,7-8H2,(H,25,26,28)	QAHGFNBWOYHCNV-UHFFFAOYSA-N	508175	US11130759, Cpd. No. 485::US11046691, Compound 485::1-(2-chlorophenyl)-7-cyclopropyl-4- (pyridin-3-ylamino)quinazolin-2(1H)- one::US11084798, Cpd No 485	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508175&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608368	459093254							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072029	Clc1ccccc1-n1c2cc(ccc2c(Nc2ccncc2)nc1=O)C1CC1 |(1.9,-4.52,;3.23,-3.75,;4.56,-4.52,;5.9,-3.75,;5.9,-2.21,;4.56,-1.44,;3.23,-2.21,;1.9,-1.44,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;-.77,.1,;-2.1,.87,;-3.44,.1,;-4.77,.87,;-6.1,.1,;-6.1,-1.44,;-4.77,-2.21,;-3.44,-1.44,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;4.56,3.18,;6.1,3.18,;5.33,4.52,)|	InChI=1S/C22H17ClN4O/c23-18-3-1-2-4-19(18)27-20-13-15(14-5-6-14)7-8-17(20)21(26-22(27)28)25-16-9-11-24-12-10-16/h1-4,7-14H,5-6H2,(H,24,25,26,28)	RKAMFFUHMBJCCX-UHFFFAOYSA-N	508176	US11130759, Cpd. No. 486::US11046691, Compound 486::1-(2-chlorophenyl)-7-cyclopropyl-4- (pyridin-4-ylamino)quinazolin-2(1H)- one::US11084798, Cpd No 486	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508176&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608745	459093255							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072030	Clc1ccccc1-n1c2cc(ccc2c(Nc2ccnc(c2)C#N)nc1=O)C1CC1 |(1.9,-4.13,;3.23,-3.36,;4.56,-4.13,;5.9,-3.36,;5.9,-1.82,;4.56,-1.05,;3.23,-1.82,;1.9,-1.05,;1.9,.49,;3.23,1.26,;3.23,2.8,;1.9,3.57,;.56,2.8,;.56,1.26,;-.77,.49,;-2.1,1.26,;-3.44,.49,;-4.77,1.26,;-6.1,.49,;-6.1,-1.05,;-4.77,-1.82,;-3.44,-1.05,;-4.77,-3.36,;-4.77,-4.9,;-.77,-1.05,;.56,-1.82,;.56,-3.36,;4.56,3.57,;6.1,3.57,;5.33,4.9,)|	InChI=1S/C23H16ClN5O/c24-19-3-1-2-4-20(19)29-21-11-15(14-5-6-14)7-8-18(21)22(28-23(29)30)27-16-9-10-26-17(12-16)13-25/h1-4,7-12,14H,5-6H2,(H,26,27,28,30)	MQAMUQGDIOOJSB-UHFFFAOYSA-N	508177	US11130759, Cpd. No. 487::US11046691, Compound 487::4-((1-(2-chlorophenyl)-7-cyclopropyl- 2-oxo-1,2-dihydroquinazolin-4- yl)amino)picolinonitrile::US11084798, Cpd No 487	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508177	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508177&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608423	459093256							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072031	COc1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)ccn1 |(-6.1,-4.52,;-4.77,-3.75,;-4.77,-2.21,;-3.44,-1.44,;-3.44,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;4.56,-1.44,;5.9,-2.21,;5.9,-3.75,;4.56,-4.52,;3.23,-3.75,;1.9,-4.52,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,;-4.77,.87,;-6.1,.1,;-6.1,-1.44,)|	InChI=1S/C23H19ClN4O2/c1-30-21-13-16(10-11-25-21)26-22-17-9-8-15(14-6-7-14)12-20(17)28(23(29)27-22)19-5-3-2-4-18(19)24/h2-5,8-14H,6-7H2,1H3,(H,25,26,27,29)	YLTPMEXOWCAHHF-UHFFFAOYSA-N	508178	US11130759, Cpd. No. 488::US11046691, Compound 488::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-methoxypyridin-4- yl)amino)quinazolin-2(1H)-one::US11084798, Cpd No 488	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508178&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608923	459093257							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072032	Clc1ccccc1-n1c2cc(ccc2c(Nc2ccnc(c2)N2CCOCC2)nc1=O)C1CC1 |(1.9,-3.36,;3.23,-2.59,;4.56,-3.36,;5.9,-2.59,;5.9,-1.05,;4.56,-.28,;3.23,-1.05,;1.9,-.28,;1.9,1.26,;3.23,2.03,;3.23,3.57,;1.9,4.34,;.56,3.57,;.56,2.03,;-.77,1.26,;-2.1,2.03,;-3.44,1.26,;-4.77,2.03,;-6.1,1.26,;-6.1,-.28,;-4.77,-1.05,;-3.44,-.28,;-4.77,-2.59,;-6.1,-3.36,;-6.1,-4.9,;-4.77,-5.67,;-3.44,-4.9,;-3.44,-3.36,;-.77,-.28,;.56,-1.05,;.56,-2.59,;4.56,4.34,;6.1,4.34,;5.33,5.67,)|	InChI=1S/C26H24ClN5O2/c27-21-3-1-2-4-22(21)32-23-15-18(17-5-6-17)7-8-20(23)25(30-26(32)33)29-19-9-10-28-24(16-19)31-11-13-34-14-12-31/h1-4,7-10,15-17H,5-6,11-14H2,(H,28,29,30,33)	HUSVNINXXZNHNR-UHFFFAOYSA-N	508179	US11046691, Compound 489::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-morpholinopyridin-4-yl)amino)- quinazolin-2(1H)-one::US11084798, Cpd No 489	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508179&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608328	459093258							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072033	Fc1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)ccn1 |(-4.77,-3.75,;-4.77,-2.21,;-3.44,-1.44,;-3.44,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;4.56,-1.44,;5.9,-2.21,;5.9,-3.75,;4.56,-4.52,;3.23,-3.75,;1.9,-4.52,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,;-4.77,.87,;-6.1,.1,;-6.1,-1.44,)|	InChI=1S/C22H16ClFN4O/c23-17-3-1-2-4-18(17)28-19-11-14(13-5-6-13)7-8-16(19)21(27-22(28)29)26-15-9-10-25-20(24)12-15/h1-4,7-13H,5-6H2,(H,25,26,27,29)	XFUJVWTXKFHAIW-UHFFFAOYSA-N	508180	US11130759, Cpd. No. 490::US11046691, Compound 490::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-fluoropyridin-4- yl)amino)quinazolin-2(1H)-one::US11084798, Cpd No 490	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508180&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608382	459093259							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072034	Clc1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)ccn1 |(-4.77,-3.75,;-4.77,-2.21,;-3.44,-1.44,;-3.44,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;4.56,-1.44,;5.9,-2.21,;5.9,-3.75,;4.56,-4.52,;3.23,-3.75,;1.9,-4.52,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,;-4.77,.87,;-6.1,.1,;-6.1,-1.44,)|	InChI=1S/C22H16Cl2N4O/c23-17-3-1-2-4-18(17)28-19-11-14(13-5-6-13)7-8-16(19)21(27-22(28)29)26-15-9-10-25-20(24)12-15/h1-4,7-13H,5-6H2,(H,25,26,27,29)	QRXMZDUFTMSKJZ-UHFFFAOYSA-N	508181	US11130759, Cpd. No. 491::US11046691, Compound 491::1-(2-chlorophenyl)-4-((2-chloropyridin- 4-yl)amino)-7-cyclopropylquinazolin- 2(1H)-one::US11084798, Cpd No 491	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508181&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608681	459093260							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072035	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(cc(OC)c12)C(F)(F)F |(-4.67,,;-3.33,.77,;-2,,;-2,-1.54,;-.67,-2.31,;-.67,-3.85,;.67,-1.54,;2,-2.31,;3.33,-1.54,;4.67,-2.31,;4.67,-3.85,;3.33,-4.62,;2,-3.85,;.67,-4.62,;.67,,;2,.77,;2,2.31,;.67,3.08,;-.67,2.31,;-2,3.08,;-3.33,2.31,;-.67,.77,;3.33,3.08,;4.67,2.31,;3.33,1.54,;3.33,4.62,)|	InChI=1S/C17H13ClF3N3O2/c1-22-15-14-12(7-9(17(19,20)21)8-13(14)26-2)24(16(25)23-15)11-6-4-3-5-10(11)18/h3-8H,1-2H3,(H,22,23,25)	CXFIWZFYRKONSQ-UHFFFAOYSA-N	508182	US11130759, Cpd. No. 492::US11046691, Compound 492::1-(2-chlorophenyl)-5-methoxy-4- (methylamino)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 492	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508182&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608700	459093261							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072036	FC(F)(F)c1ccc2c(NCC3CC3)nc(=O)n(-c3ccccc3Cl)c2c1 |(6.1,2.31,;4.77,3.08,;4.77,1.54,;4.77,4.62,;3.44,2.31,;2.1,3.08,;.77,2.31,;.77,.77,;-.56,,;-1.9,.77,;-3.23,,;-4.56,.77,;-5.33,2.1,;-6.1,.77,;-.56,-1.54,;.77,-2.31,;.77,-3.85,;2.1,-1.54,;3.44,-2.31,;4.77,-1.54,;6.1,-2.31,;6.1,-3.85,;4.77,-4.62,;3.44,-3.85,;2.1,-4.62,;2.1,,;3.44,.77,)|	InChI=1S/C19H15ClF3N3O/c20-14-3-1-2-4-15(14)26-16-9-12(19(21,22)23)7-8-13(16)17(25-18(26)27)24-10-11-5-6-11/h1-4,7-9,11H,5-6,10H2,(H,24,25,27)	XWAKLORVMSCURS-UHFFFAOYSA-N	508183	US11130759, Cpd. No. 493::US11046691, Compound 493::1-(2-chlorophenyl)-4-((cyclopropyl- methyl)amino)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 493	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508183	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508183&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609037	459093262							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072037	CNc1nc(=O)n(-c2ccccc2)c2cc(cc(OC)c12)C(F)(F)F	InChI=1S/C17H14F3N3O2/c1-21-15-14-12(8-10(17(18,19)20)9-13(14)25-2)23(16(24)22-15)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,21,22,24)	GOYUMRAIDPYUNE-UHFFFAOYSA-N	508184	US11130759, Cpd. No. 494::US11046691, Compound 494::5-methoxy-4-(methylamino)-1-phenyl- 7-(trifluoromethyl)quinazolin-2(1H)- one::US11084798, Cpd No 494	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508184&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150327567	459093263							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072038	C[C@@H](Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F)C(F)(F)F |r,wD:1.0,(-3.33,-1.54,;-3.33,,;-2,.77,;-.67,,;-.67,-1.54,;.67,-2.31,;.67,-3.85,;2,-1.54,;3.33,-2.31,;4.67,-1.54,;6,-2.31,;6,-3.85,;4.67,-4.62,;3.33,-3.85,;2,-4.62,;2,,;3.33,.77,;3.33,2.31,;2,3.08,;.67,2.31,;.67,.77,;4.67,3.08,;6,2.31,;4.67,1.54,;4.67,4.62,;-4.67,.77,;-6,,;-4.67,2.31,;-4.67,-.77,)|	InChI=1S/C18H12ClF6N3O/c1-9(17(20,21)22)26-15-11-7-6-10(18(23,24)25)8-14(11)28(16(29)27-15)13-5-3-2-4-12(13)19/h2-9H,1H3,(H,26,27,29)	LTCVSTBBMUNTMX-UHFFFAOYSA-N	508185	US11130759, Cpd. No. 495::US11046691, Compound 495::(R)-1-(2-chlorophenyl)-7-(trifluoro- methyl)-4-((1,1,1-trifluoropropan-2-yl)- amino)quinazolin-2(1H)-one::US11084798, Cpd No 495	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508185	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508185&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608981	459093264							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072039	FC(F)(F)c1ccc2c(N[C@H]3C[C@@H](C3)C#N)nc(=O)n(-c3ccccc3Cl)c2c1 |r,wU:12.14,wD:10.9,(6.94,2.31,;5.61,3.08,;5.61,1.54,;5.61,4.62,;4.28,2.31,;2.94,3.08,;1.61,2.31,;1.61,.77,;.28,,;-1.06,.77,;-2.39,,;-3.88,.4,;-4.28,-1.09,;-2.79,-1.49,;-5.61,-1.86,;-6.94,-2.63,;.28,-1.54,;1.61,-2.31,;1.61,-3.85,;2.94,-1.54,;4.28,-2.31,;5.61,-1.54,;6.94,-2.31,;6.94,-3.85,;5.61,-4.62,;4.28,-3.85,;2.94,-4.62,;2.94,,;4.28,.77,)|	InChI=1S/C20H14ClF3N4O/c21-15-3-1-2-4-16(15)28-17-9-12(20(22,23)24)5-6-14(17)18(27-19(28)29)26-13-7-11(8-13)10-25/h1-6,9,11,13H,7-8H2,(H,26,27,29)	FGMJBBZHPMPGCY-UHFFFAOYSA-N	508186	US11130759, Cpd. No. 496::US11046691, Compound 496::(1,3-trans)-3-((1-(2-chlorophenyl)-2- oxo-7-(trifluoromethyl)-1,2-dihydro- quinazolin-4-yl)amino)-cyclobutane-1- carbonitrile::US11084798, Cpd No 496	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508186&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608235	459093265							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072040	CC(C)Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C18H16F3N3O/c1-11(2)22-16-14-9-8-12(18(19,20)21)10-15(14)24(17(25)23-16)13-6-4-3-5-7-13/h3-11H,1-2H3,(H,22,23,25)	SXFZBYMTZZGIJA-UHFFFAOYSA-N	508187	US11130759, Cpd. No. 497::US11046691, Compound 497::4-(isopropylamino)-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 497	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508187	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508187&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151923399	459093266							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072041	CC(C)Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |(-4,-1.54,;-4,,;-5.33,.77,;-2.67,.77,;-1.33,,;-1.33,-1.54,;,-2.31,;,-3.85,;1.33,-1.54,;2.67,-2.31,;4,-1.54,;5.33,-2.31,;5.33,-3.85,;4,-4.62,;2.67,-3.85,;1.33,-4.62,;1.33,,;2.67,.77,;2.67,2.31,;1.33,3.08,;,2.31,;,.77,;4,3.08,;5.33,2.31,;4,1.54,;4,4.62,)|	InChI=1S/C18H15ClF3N3O/c1-10(2)23-16-12-8-7-11(18(20,21)22)9-15(12)25(17(26)24-16)14-6-4-3-5-13(14)19/h3-10H,1-2H3,(H,23,24,26)	LEYFKFJFNSNDJE-UHFFFAOYSA-N	508188	US11130759, Cpd. No. 498::US11046691, Compound 498::1-(2-chlorophenyl)-4-(isopropylamino)- 7-(trifluoromethyl)quinazolin-2(1H)- one::US11084798, Cpd No 498	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508188	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508188&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608720	459093267							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072042	FC(F)(F)c1ccc2c(NC3CC3)nc(=O)n(-c3ccccc3Cl)c2c1 |(5.44,2.31,;4.1,3.08,;4.1,1.54,;4.1,4.62,;2.77,2.31,;1.44,3.08,;.1,2.31,;.1,.77,;-1.23,,;-2.56,.77,;-3.9,,;-5.44,,;-4.67,-1.33,;-1.23,-1.54,;.1,-2.31,;.1,-3.85,;1.44,-1.54,;2.77,-2.31,;4.1,-1.54,;5.44,-2.31,;5.44,-3.85,;4.1,-4.62,;2.77,-3.85,;1.44,-4.62,;1.44,,;2.77,.77,)|	InChI=1S/C18H13ClF3N3O/c19-13-3-1-2-4-14(13)25-15-9-10(18(20,21)22)5-8-12(15)16(24-17(25)26)23-11-6-7-11/h1-5,8-9,11H,6-7H2,(H,23,24,26)	NIYZCOSSKYBDRE-UHFFFAOYSA-N	508189	US11130759, Cpd. No. 499::US11046691, Compound 499::1-(2-chlorophenyl)-4-(cyclopropyl- amino)-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 499	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508189&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608976	459093268							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072043	FC(F)(F)c1ccc2c(Nc3cnoc3)nc(=O)n(-c3ccccc3Cl)c2c1 |(5.85,2.31,;4.52,3.08,;4.52,1.54,;4.52,4.62,;3.19,2.31,;1.85,3.08,;.52,2.31,;.52,.77,;-.82,,;-2.15,.77,;-3.48,,;-3.48,-1.54,;-4.95,-2.02,;-5.85,-.77,;-4.95,.48,;-.82,-1.54,;.52,-2.31,;.52,-3.85,;1.85,-1.54,;3.19,-2.31,;4.52,-1.54,;5.85,-2.31,;5.85,-3.85,;4.52,-4.62,;3.19,-3.85,;1.85,-4.62,;1.85,,;3.19,.77,)|	InChI=1S/C18H10ClF3N4O2/c19-13-3-1-2-4-14(13)26-15-7-10(18(20,21)22)5-6-12(15)16(25-17(26)27)24-11-8-23-28-9-11/h1-9H,(H,24,25,27)	YCROAJJADDQBBJ-UHFFFAOYSA-N	508190	US11130759, Cpd. No. 500::US11046691, Compound 500::1-(2-chlorophenyl)-4-(isoxazol-4-yl- amino)-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 500	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508190	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508190&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608355	459093269							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072044	FCC(CF)Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |(-5.33,2.31,;-5.33,.77,;-4,,;-4,-1.54,;-2.67,-2.31,;-2.67,.77,;-1.33,,;-1.33,-1.54,;,-2.31,;,-3.85,;1.33,-1.54,;2.67,-2.31,;4,-1.54,;5.33,-2.31,;5.33,-3.85,;4,-4.62,;2.67,-3.85,;1.33,-4.62,;1.33,,;2.67,.77,;2.67,2.31,;1.33,3.08,;,2.31,;,.77,;4,3.08,;5.33,2.31,;4,1.54,;4,4.62,)|	InChI=1S/C18H13ClF5N3O/c19-13-3-1-2-4-14(13)27-15-7-10(18(22,23)24)5-6-12(15)16(26-17(27)28)25-11(8-20)9-21/h1-7,11H,8-9H2,(H,25,26,28)	JPRFOSSKZCSSJQ-UHFFFAOYSA-N	508191	US11130759, Cpd. No. 501::US11046691, Compound 501::1-(2-chlorophenyl)-4((1,3-difluoro- propan-2-yl)amino)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 501	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508191	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508191&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608747	459093270							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072045	F[C@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |r,wU:3.4,1.0,(-4.67,-2.87,;-4.67,-1.33,;-5.44,,;-3.9,,;-2.56,.77,;-1.23,,;-1.23,-1.54,;.1,-2.31,;.1,-3.85,;1.44,-1.54,;2.77,-2.31,;4.1,-1.54,;5.44,-2.31,;5.44,-3.85,;4.1,-4.62,;2.77,-3.85,;1.44,-4.62,;1.44,,;2.77,.77,;2.77,2.31,;1.44,3.08,;.1,2.31,;.1,.77,;4.1,3.08,;5.44,2.31,;4.1,1.54,;4.1,4.62,)|	InChI=1S/C18H12ClF4N3O/c19-11-3-1-2-4-14(11)26-15-7-9(18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	KOFRWFSRZWFLEJ-UHFFFAOYSA-N	508192	US11130759, Cpd. No. 502::US11046691, Compound 502::1-(2-chlorophenyl)-4-(((1R,2S)-2- fluorocyclopropyl)amino)-7-(trifluoro- methyl)quinazolin-2(1H)-one::US11084798, Cpd No 502	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508192	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508192&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608524	459093271							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072046	F[C@@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |r,wD:3.4,1.0,(-4.67,-2.87,;-4.67,-1.33,;-5.44,,;-3.9,,;-2.56,.77,;-1.23,,;-1.23,-1.54,;.1,-2.31,;.1,-3.85,;1.44,-1.54,;2.77,-2.31,;4.1,-1.54,;5.44,-2.31,;5.44,-3.85,;4.1,-4.62,;2.77,-3.85,;1.44,-4.62,;1.44,,;2.77,.77,;2.77,2.31,;1.44,3.08,;.1,2.31,;.1,.77,;4.1,3.08,;5.44,2.31,;4.1,1.54,;4.1,4.62,)|	InChI=1S/C18H12ClF4N3O/c19-11-3-1-2-4-14(11)26-15-7-9(18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	KOFRWFSRZWFLEJ-UHFFFAOYSA-N	508193	US11130759, Cpd. No. 503::US11046691, Compound 503::1-(2-chlorophenyl)-4-(((1S,2R)-2- fluorocyclopropyl)amino)-7-(trifluoro- methyl)quinazolin-2(1H)-one::US11084798, Cpd No 503	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508193	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508193&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608952	459093272							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072047	FC(F)(F)c1ccc2c(NCC3CC3)nc(=O)n(-c3ccccc3)c2c1	InChI=1S/C19H16F3N3O/c20-19(21,22)13-8-9-15-16(10-13)25(14-4-2-1-3-5-14)18(26)24-17(15)23-11-12-6-7-12/h1-5,8-10,12H,6-7,11H2,(H,23,24,26)	GQCZSRHFIDHCTF-UHFFFAOYSA-N	508194	US11130759, Cpd. No. 504::US11046691, Compound 504::4-((cyclopropylmethyl)amino)-1- phenyl-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 504	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508194	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508194&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150333238	459093273							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072048	CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(C)C	InChI=1S/C18H19N3O/c1-12(2)13-9-10-15-16(11-13)21(14-7-5-4-6-8-14)18(22)20-17(15)19-3/h4-12H,1-3H3,(H,19,20,22)	POCCSOGKVXFMKQ-UHFFFAOYSA-N	508195	US11130759, Cpd. No. 505::US11046691, Compound 505::7-isopropyl-4-(methylamino)-1-phenyl- quinazolin-2(1H)-one::US11084798, Cpd No 505	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508195	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508195&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151489154	459093274							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072049	FC(F)(F)c1ccc2c(NC3CC3(F)F)nc(=O)n(-c3ccccc3)c2c1 |w:9.9|	InChI=1S/C18H12F5N3O/c19-17(20)9-14(17)24-15-12-7-6-10(18(21,22)23)8-13(12)26(16(27)25-15)11-4-2-1-3-5-11/h1-8,14H,9H2,(H,24,25,27)	OFIOIICJYUTPTN-UHFFFAOYSA-N	508196	US11130759, Cpd. No. 506::US11046691, Compound 506::4-((2,2-difluorocyclopropyl)amino)-1- phenyl-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 506	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508196	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508196&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151315556	459093275							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072050	FCC(CF)Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C18H14F5N3O/c19-9-12(10-20)24-16-14-7-6-11(18(21,22)23)8-15(14)26(17(27)25-16)13-4-2-1-3-5-13/h1-8,12H,9-10H2,(H,24,25,27)	IUUYRNHUVCJGFJ-UHFFFAOYSA-N	508197	US11130759, Cpd. No. 507::US11046691, Compound 507::4-((1,3-difluoropropan-2-yl)amino)-1- phenyl-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 507	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508197	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508197&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150615619	459093276							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072051	C[C@@H](Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H18F3N3O/c1-12(13-7-8-13)24-18-16-10-9-14(20(21,22)23)11-17(16)26(19(27)25-18)15-5-3-2-4-6-15/h2-6,9-13H,7-8H2,1H3,(H,24,25,27)	GZSDGOSGLQFVJF-UHFFFAOYSA-N	508198	US11130759, Cpd. No. 508::US11046691, Compound 508::(R)-4-((1-cyclopropylethyl)amino)-1- phenyl-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 508	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508198	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508198&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150380887	459093277							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072052	FC(F)(F)c1ccc2c(NCC3(F)CC3)nc(=O)n(-c3ccccc3)c2c1	InChI=1S/C19H15F4N3O/c20-18(8-9-18)11-24-16-14-7-6-12(19(21,22)23)10-15(14)26(17(27)25-16)13-4-2-1-3-5-13/h1-7,10H,8-9,11H2,(H,24,25,27)	DTDDJTLBIYEHFB-UHFFFAOYSA-N	508199	US11130759, Cpd. No. 509::US11046691, Compound 509::4-(((1- fluorocyclopropyl)methyl)amino)-1- phenyl-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 509	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508199	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508199&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608252	459093278							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072053	OC[C@H]1C[C@@H]1CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F |r|	InChI=1S/C20H18F3N3O2/c21-20(22,23)14-6-7-16-17(9-14)26(15-4-2-1-3-5-15)19(28)25-18(16)24-10-12-8-13(12)11-27/h1-7,9,12-13,27H,8,10-11H2,(H,24,25,28)	HSGBYPVNYSFDNP-UHFFFAOYSA-N	508200	US11130759, Cpd. No. 510::US11046691, Compound 510::4-((((trans)-2-(hydroxymethyl)cyclo- propyl)methyl)amino)-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 510	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508200&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608566	459093279							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072054	CNc1nc(=O)n(-c2cccc3nccn23)c2cc(ccc12)C(F)(F)F |(-4.67,.83,;-3.33,1.6,;-2,.83,;-2,-.71,;-.67,-1.48,;-.67,-3.02,;.67,-.71,;2,-1.48,;3.33,-.71,;4.67,-1.48,;4.67,-3.02,;3.33,-3.79,;3.01,-5.29,;1.48,-5.45,;.86,-4.05,;2,-3.02,;.67,.83,;2,1.6,;2,3.14,;.67,3.91,;-.67,3.14,;-.67,1.6,;3.33,3.91,;4.67,3.14,;3.33,5.45,;3.33,2.37,)|	InChI=1S/C17H12F3N5O/c1-21-15-11-6-5-10(17(18,19)20)9-12(11)25(16(26)23-15)14-4-2-3-13-22-7-8-24(13)14/h2-9H,1H3,(H,21,23,26)	QPNFPNCMROMFGW-UHFFFAOYSA-N	508201	US11130759, Cpd. No. 511::US11046691, Compound 511::1-(imidazo[1,2-a]pyridin-5-yl)-4- (methylamino)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 511	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508201	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508201&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608231	459093280							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072055	CNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C1CC1 |(-4.77,.1,;-3.44,.87,;-2.1,.1,;-2.1,-1.44,;-.77,-2.21,;-.77,-3.75,;.56,-1.44,;1.9,-2.21,;3.23,-1.44,;4.56,-2.21,;4.56,-3.75,;3.23,-4.52,;1.9,-3.75,;.56,-4.52,;.56,.1,;1.9,.87,;1.9,2.41,;.56,3.18,;-.77,2.41,;-.77,.87,;3.23,3.18,;4.77,3.18,;4,4.52,)|	InChI=1S/C17H15ClN4O/c1-19-15-11-8-9-13(10-6-7-10)20-16(11)22(17(23)21-15)14-5-3-2-4-12(14)18/h2-5,8-10H,6-7H2,1H3,(H,19,21,23)	HMDQEEQNLNTRII-UHFFFAOYSA-N	508202	US11130759, Cpd. No. 512::US11046691, Compound 512::1-(2-chlorophenyl)-7-cyclopropyl-4- (methylamino)pyrido[2,3-d]pyrimidin- 2(1H)-one::US11084798, Cpd No 512	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508202	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508202&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608309	459093281							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072056	CNc1nc(=O)n(-c2cccc3nccn23)c2nc(ccc12)C1CC1 |(-4.77,.94,;-3.44,1.71,;-2.1,.94,;-2.1,-.6,;-.77,-1.37,;-.77,-2.91,;.56,-.6,;1.9,-1.37,;3.23,-.6,;4.56,-1.37,;4.56,-2.91,;3.23,-3.68,;2.91,-5.19,;1.38,-5.35,;.75,-3.94,;1.9,-2.91,;.56,.94,;1.9,1.71,;1.9,3.25,;.56,4.02,;-.77,3.25,;-.77,1.71,;3.23,4.02,;4.77,4.02,;4,5.35,)|	InChI=1S/C18H16N6O/c1-19-16-12-7-8-13(11-5-6-11)21-17(12)24(18(25)22-16)15-4-2-3-14-20-9-10-23(14)15/h2-4,7-11H,5-6H2,1H3,(H,19,22,25)	SZXUJVHFESWKFS-UHFFFAOYSA-N	508203	US11130759, Cpd. No. 513::US11046691, Compound 513::7-cyclopropyl-1-(imidazo[1,2- a]pyridin-5-yl)-4- (methylamino)pyrido[2,3-d]-pyrimidin- 2(1H)-one::US11084798, Cpd No 513	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508203	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508203&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608283	459093282							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072057	CNc1nc(=O)n(-c2ccccc2)c2nc(OC)ccc12	InChI=1S/C15H14N4O2/c1-16-13-11-8-9-12(21-2)17-14(11)19(15(20)18-13)10-6-4-3-5-7-10/h3-9H,1-2H3,(H,16,18,20)	IHKCVLNXBAXUSH-UHFFFAOYSA-N	508204	US11130759, Cpd. No. 514::US11046691, Compound 514::7-methoxy-4-(methylamino)-1-phenyl- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 514	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508204	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508204&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150548653	459093283							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072058	CNc1nc(=O)n(-c2ncccc2Cl)c2cc(ccc12)C(F)(F)F |(-4.67,,;-3.33,.77,;-2,,;-2,-1.54,;-.67,-2.31,;-.67,-3.85,;.67,-1.54,;2,-2.31,;3.33,-1.54,;4.67,-2.31,;4.67,-3.85,;3.33,-4.62,;2,-3.85,;.67,-4.62,;.67,,;2,.77,;2,2.31,;.67,3.08,;-.67,2.31,;-.67,.77,;3.33,3.08,;4.67,2.31,;3.33,4.62,;3.33,1.54,)|	InChI=1S/C15H10ClF3N4O/c1-20-12-9-5-4-8(15(17,18)19)7-11(9)23(14(24)22-12)13-10(16)3-2-6-21-13/h2-7H,1H3,(H,20,22,24)	KPJIFPDQAKKCTF-UHFFFAOYSA-N	508205	US11130759, Cpd. No. 515::US11046691, Compound 515::1-(3-chloropyridin-2-yl)-4-(methyl- amino)-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 515	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508205	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508205&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608448	459093284							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072059	CNc1nc(=O)n(-c2cccnc2C(F)(F)F)c2cc(ccc12)C(F)(F)F |(-4.67,.74,;-3.33,1.51,;-2,.74,;-2,-.8,;-.67,-1.57,;-.67,-3.11,;.67,-.8,;2,-1.57,;3.33,-.8,;4.67,-1.57,;4.67,-3.11,;3.33,-3.88,;2,-3.11,;.67,-3.88,;-.82,-4.27,;.27,-5.36,;1.76,-4.97,;.67,.74,;2,1.51,;2,3.05,;.67,3.82,;-.67,3.05,;-.67,1.51,;3.33,3.82,;4.67,3.05,;3.33,5.36,;3.33,2.28,)|	InChI=1S/C16H10F6N4O/c1-23-13-9-5-4-8(15(17,18)19)7-11(9)26(14(27)25-13)10-3-2-6-24-12(10)16(20,21)22/h2-7H,1H3,(H,23,25,27)	JOHAQLMGDKULJS-UHFFFAOYSA-N	508206	US11130759, Cpd. No. 516::US11046691, Compound 516::4-(methylamino)-7-(trifluoromethyl)-1- (2-(trifluoromethyl)pyridin-3-yl)- quinazolin-2(1H)-one::US11084798, Cpd No 516	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508206	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508206&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150712971	459093285							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072060	CNc1nc(=O)n(-c2cncnc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C14H10F3N5O/c1-18-12-10-3-2-8(14(15,16)17)4-11(10)22(13(23)21-12)9-5-19-7-20-6-9/h2-7H,1H3,(H,18,21,23)	CCMNBCFOESQZIV-UHFFFAOYSA-N	508207	US11130759, Cpd. No. 517::US11046691, Compound 517::4-(methylamino)-1-(pyrimidin-5-yl)-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 517	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508207&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149877624	459093286							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072061	C[C@H](Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C18H13F6N3O/c1-10(17(19,20)21)25-15-13-8-7-11(18(22,23)24)9-14(13)27(16(28)26-15)12-5-3-2-4-6-12/h2-10H,1H3,(H,25,26,28)	WROYSEKVCIBRFO-UHFFFAOYSA-N	508208	US11130759, Cpd. No. 518::US11046691, Compound 518::(S)-1-phenyl-7-(trifluoromethyl)-4- ((1,1,1-trifluoropropan-2-yl)amino)- quinazolin-2(1H)-one::US11084798, Cpd No 518	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508208	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508208&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608282	459093287							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072062	FC(F)(F)c1ccc2c(NCC3CCO3)nc(=O)n(-c3ccccc3)c2c1 |w:10.10|	InChI=1S/C19H16F3N3O2/c20-19(21,22)12-6-7-15-16(10-12)25(13-4-2-1-3-5-13)18(26)24-17(15)23-11-14-8-9-27-14/h1-7,10,14H,8-9,11H2,(H,23,24,26)	NMELCGFOZVCHOC-UHFFFAOYSA-N	508209	US11046691, Compound 519::4-((oxetan-2-ylmethyl)amino)-1- phenyl-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 519	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508209	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508209&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151220514	459093288							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072063	F[C@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F |r|	InChI=1S/C18H13F4N3O/c19-13-9-14(13)23-16-12-7-6-10(18(20,21)22)8-15(12)25(17(26)24-16)11-4-2-1-3-5-11/h1-8,13-14H,9H2,(H,23,24,26)	UFSKLHVXDCCBMV-UHFFFAOYSA-N	508210	US11130759, Cpd. No. 520::US11046691, Compound 520::4-(((1R,2S)-2- fluorocyclopropyl)amino)-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 520	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508210	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508210&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152903119	459093289							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072064	F[C@@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F |r|	InChI=1S/C18H13F4N3O/c19-13-9-14(13)23-16-12-7-6-10(18(20,21)22)8-15(12)25(17(26)24-16)11-4-2-1-3-5-11/h1-8,13-14H,9H2,(H,23,24,26)	UFSKLHVXDCCBMV-UHFFFAOYSA-N	512186	US11130759, Cpd. No. 521::US11084798, Cpd No 521::4-(((1,2-trans)-2-fluorocyclopropyl)- amino)-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=512186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=512186&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154929316	459629435							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072065	FC(F)(F)c1ccc2c(NCC3CC3(F)F)nc(=O)n(-c3ccccc3)c2c1 |w:10.10|	InChI=1S/C19H14F5N3O/c20-18(21)9-12(18)10-25-16-14-7-6-11(19(22,23)24)8-15(14)27(17(28)26-16)13-4-2-1-3-5-13/h1-8,12H,9-10H2,(H,25,26,28)	KLRCPZVEQUXTBJ-UHFFFAOYSA-N	508212	US11046691, Compound 522::4-(((2,2-difluorocyc1opropyl)methyl)- amino)-1-phenyl-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 522	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508212	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508212&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150829561	459093291							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072066	C[C@H](CO)Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F |r|	InChI=1S/C18H16F3N3O2/c1-11(10-25)22-16-14-8-7-12(18(19,20)21)9-15(14)24(17(26)23-16)13-5-3-2-4-6-13/h2-9,11,25H,10H2,1H3,(H,22,23,26)	VBNROUJWWPXKEM-UHFFFAOYSA-N	508213	US11130759, Cpd. No. 523::US11046691, Compound 523::(R)-4-((1-hydroxypropan-2-yl)amino)- 1-phenyl-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 523	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508213&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608241	459093292							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072067	FC(F)(F)c1ccc2c(NC3COC3)nc(=O)n(-c3ccccc3)c2c1	InChI=1S/C18H14F3N3O2/c19-18(20,21)11-6-7-14-15(8-11)24(13-4-2-1-3-5-13)17(25)23-16(14)22-12-9-26-10-12/h1-8,12H,9-10H2,(H,22,23,25)	IZXYVXBRLKQXDU-UHFFFAOYSA-N	508214	US11130759, Cpd. No. 524::US11046691, Compound 524::4-(oxetan-3-ylamino)-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 524	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508214	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508214&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150641167	459093293							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072068	CO[C@H]1C[C@@H](C1)Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F |r,wU:2.1,wD:4.6,(-6.94,-1.09,;-5.61,-1.86,;-4.28,-1.09,;-3.88,.4,;-2.39,,;-2.79,-1.49,;-1.06,.77,;.28,,;.28,-1.54,;1.61,-2.31,;1.61,-3.85,;2.94,-1.54,;4.28,-2.31,;5.61,-1.54,;6.94,-2.31,;6.94,-3.85,;5.61,-4.62,;4.28,-3.85,;2.94,,;4.28,.77,;4.28,2.31,;2.94,3.08,;1.61,2.31,;1.61,.77,;5.61,3.08,;6.94,2.31,;5.61,4.62,;5.61,1.54,)|	InChI=1S/C20H18F3N3O2/c1-28-15-10-13(11-15)24-18-16-8-7-12(20(21,22)23)9-17(16)26(19(27)25-18)14-5-3-2-4-6-14/h2-9,13,15H,10-11H2,1H3,(H,24,25,27)	YHAKYDDPLNQCTE-UHFFFAOYSA-N	508215	US11130759, Cpd. No. 525::US11046691, Compound 525::4-(((1,3-trans)-3-methoxycyclobutyl)- amino)-1-phenyl-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 525	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508215&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608344	459093294							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072069	COCCCNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C19H18F3N3O2/c1-27-11-5-10-23-17-15-9-8-13(19(20,21)22)12-16(15)25(18(26)24-17)14-6-3-2-4-7-14/h2-4,6-9,12H,5,10-11H2,1H3,(H,23,24,26)	ATMZANDGYSEQKA-UHFFFAOYSA-N	508216	US11130759, Cpd. No. 528::4-((3-methoxypropyl)amino)-1-phenyl- 7-(trifluoromethyl)quinazolin-2(1H)- one::US11046691, Compound 528::US11046691, Compound 526::US11084798, Cpd No 528	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508216	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508216&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608909	459093295							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072070	COCCNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C18H16F3N3O2/c1-26-10-9-22-16-14-8-7-12(18(19,20)21)11-15(14)24(17(25)23-16)13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,22,23,25)	KHOJFNLZDMYDQQ-UHFFFAOYSA-N	508217	US11130759, Cpd. No. 527::US11046691, Compound 527::4-((2-methoxyethyl)amino)-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 527	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508217	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508217&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150809357	459093296							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072071	COCCCNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C19H18F3N3O2/c1-27-11-5-10-23-17-15-9-8-13(19(20,21)22)12-16(15)25(18(26)24-17)14-6-3-2-4-7-14/h2-4,6-9,12H,5,10-11H2,1H3,(H,23,24,26)	ATMZANDGYSEQKA-UHFFFAOYSA-N	508216	US11130759, Cpd. No. 528::4-((3-methoxypropyl)amino)-1-phenyl- 7-(trifluoromethyl)quinazolin-2(1H)- one::US11046691, Compound 528::US11046691, Compound 526::US11084798, Cpd No 528	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508216	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508216&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608909	459093295							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072073	FC(F)OCCNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F	InChI=1S/C18H14F5N3O2/c19-16(20)28-9-8-24-15-13-7-6-11(18(21,22)23)10-14(13)26(17(27)25-15)12-4-2-1-3-5-12/h1-7,10,16H,8-9H2,(H,24,25,27)	BWVUIKCGPQTGSS-UHFFFAOYSA-N	508219	US11130759, Cpd. No. 530::US11046691, Compound 530::4-((2-(difluoromethoxy)ethyl)amino)-1- phenyl-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 530	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508219&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149849441	459093297							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072074	CNc1nc(=O)n(-c2ccccc2)c2nc(ccc12)C1CC1	InChI=1S/C17H16N4O/c1-18-15-13-9-10-14(11-7-8-11)19-16(13)21(17(22)20-15)12-5-3-2-4-6-12/h2-6,9-11H,7-8H2,1H3,(H,18,20,22)	TYBFHHKTCGJIOK-UHFFFAOYSA-N	508220	US11130759, Cpd. No. 531::US11046691, Compound 531::7-cyclopropyl-4-(methylamino)-1- phenylpyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 531	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508220	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508220&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151958072	459093298							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072075	Cc1ccccc1-n1c2nc(ccc2c(nc1=O)N1CC[C@@H](CO)C1)C(F)(F)F |r,wU:21.24,(4.34,-.03,;4.34,-1.57,;5.68,-2.34,;5.68,-3.88,;4.34,-4.65,;3.01,-3.88,;3.01,-2.34,;1.68,-1.57,;1.68,-.03,;3.01,.74,;3.01,2.28,;1.68,3.05,;.34,2.28,;.34,.74,;-.99,-.03,;-.99,-1.57,;.34,-2.34,;.34,-3.88,;-2.33,.74,;-3.79,.27,;-4.7,1.51,;-3.79,2.76,;-4.19,4.25,;-5.68,4.65,;-2.33,2.28,;4.34,3.05,;5.68,2.28,;4.34,4.59,;5.68,3.82,)|	InChI=1S/C20H19F3N4O2/c1-12-4-2-3-5-15(12)27-18-14(6-7-16(24-18)20(21,22)23)17(25-19(27)29)26-9-8-13(10-26)11-28/h2-7,13,28H,8-11H2,1H3	NMSMRQWRGKFZRN-UHFFFAOYSA-N	508221	US11130759, Cpd. No. 532::US11046691, Compound 532::(R)-4-(3-(hydroxymethyl)pyrrolidin-1- yl)-1-(o-tolyl)-7-(trifluoromethyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 532	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508221	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508221&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608841	459093299							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072076	Cc1ccccc1-n1c2nc(ccc2c(nc1=O)N1CCC[C@@H]1CO)C(F)(F)F |r,wD:22.26,(3.85,,;3.85,-1.54,;5.19,-2.31,;5.19,-3.85,;3.85,-4.62,;2.52,-3.85,;2.52,-2.31,;1.18,-1.54,;1.18,,;2.52,.77,;2.52,2.31,;1.18,3.08,;-.15,2.31,;-.15,.77,;-1.48,,;-1.48,-1.54,;-.15,-2.31,;-.15,-3.85,;-2.82,.77,;-4.28,.29,;-5.19,1.54,;-4.28,2.79,;-2.82,2.31,;-1.48,3.08,;-1.48,4.62,;3.85,3.08,;5.19,2.31,;3.85,4.62,;5.19,3.85,)|	InChI=1S/C20H19F3N4O2/c1-12-5-2-3-7-15(12)27-18-14(8-9-16(24-18)20(21,22)23)17(25-19(27)29)26-10-4-6-13(26)11-28/h2-3,5,7-9,13,28H,4,6,10-11H2,1H3	OTTICQSIKIWRBD-UHFFFAOYSA-N	508222	US11130759, Cpd. No. 533::US11046691, Compound 533::(R)-4-(2-(hydroxymethyl)pyrrolidin-1- yl)-1-(o-tolyl)-7- (trifluoromethyl)pyrido-[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 533	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508222	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508222&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608740	459093300							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072077	Cc1ccccc1-n1c2nc(ccc2c(nc1=O)N1CCCC1)C(F)(F)F |(3.85,,;3.85,-1.54,;5.19,-2.31,;5.19,-3.85,;3.85,-4.62,;2.52,-3.85,;2.52,-2.31,;1.18,-1.54,;1.18,,;2.52,.77,;2.52,2.31,;1.18,3.08,;-.15,2.31,;-.15,.77,;-1.48,,;-1.48,-1.54,;-.15,-2.31,;-.15,-3.85,;-2.82,.77,;-2.82,2.31,;-4.28,2.79,;-5.19,1.54,;-4.28,.29,;3.85,3.08,;5.19,2.31,;3.85,4.62,;5.19,3.85,)|	InChI=1S/C19H17F3N4O/c1-12-6-2-3-7-14(12)26-17-13(8-9-15(23-17)19(20,21)22)16(24-18(26)27)25-10-4-5-11-25/h2-3,6-9H,4-5,10-11H2,1H3	GPPXATBUUYZNPT-UHFFFAOYSA-N	508223	US11130759, Cpd. No. 534::US11046691, Compound 534::4-(pyrrolidin-1-yl)-1-(o-tolyl)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 534	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508223&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150330776	459093301							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072078	Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1CCC(CCO)C1)C(F)(F)F |(4.94,-.42,;4.94,-1.96,;6.27,-2.73,;6.27,-4.27,;4.94,-5.04,;3.61,-4.27,;3.61,-2.73,;2.27,-1.96,;2.27,-.42,;3.61,.35,;3.61,1.89,;2.27,2.66,;.94,1.89,;.94,.35,;-.39,-.42,;-.39,-1.96,;.94,-2.73,;.94,-4.27,;-1.73,.35,;-3.19,-.12,;-4.1,1.12,;-3.19,2.37,;-3.96,3.7,;-5.5,3.7,;-6.27,5.04,;-1.73,1.89,;4.94,2.66,;6.27,1.89,;4.94,4.2,;6.27,3.43,)|	InChI=1S/C22H22F3N3O2/c1-14-4-2-3-5-18(14)28-19-12-16(22(23,24)25)6-7-17(19)20(26-21(28)30)27-10-8-15(13-27)9-11-29/h2-7,12,15,29H,8-11,13H2,1H3	VSRXCASFYUWWNP-UHFFFAOYSA-N	508224	US11130759, Cpd. No. 535::US11046691, Compound 535::4-(3-(2-hydroxyethyl)pyrrolidin-1-yl)- 1-(o-tolyl)-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 535	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508224	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508224&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608409	459093302							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072079	COC[C@H]1CCCN1c1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F |r,wD:3.2,(-.15,5,;-1.48,4.23,;-1.48,2.69,;-2.82,1.93,;-4.28,2.4,;-5.19,1.15,;-4.28,-.09,;-2.82,.38,;-1.48,-.38,;-1.48,-1.93,;-.15,-2.69,;-.15,-4.23,;1.18,-1.93,;2.52,-2.69,;2.52,-4.23,;3.85,-5,;5.19,-4.23,;5.19,-2.69,;3.85,-1.93,;3.85,-.38,;1.18,-.38,;2.52,.38,;2.52,1.93,;1.18,2.69,;-.15,1.93,;-.15,.38,;3.85,2.69,;5.19,1.93,;3.85,4.23,;5.19,3.47,)|	InChI=1S/C22H22F3N3O2/c1-14-6-3-4-8-18(14)28-19-12-15(22(23,24)25)9-10-17(19)20(26-21(28)29)27-11-5-7-16(27)13-30-2/h3-4,6,8-10,12,16H,5,7,11,13H2,1-2H3	RHFYNKJTFLFMCV-UHFFFAOYSA-N	508225	US11130759, Cpd. No. 536::US11046691, Compound 536::(R)-4-(2-(methoxymethyl)pyrrolidin-1- yl)-1-(o-tolyl)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 536	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508225	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508225&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151714439	459093303							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072080	Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1CC[C@@H](CO)C1)C(F)(F)F |r,wU:21.24,(4.58,,;4.58,-1.54,;5.91,-2.31,;5.91,-3.85,;4.58,-4.62,;3.25,-3.85,;3.25,-2.31,;1.91,-1.54,;1.91,,;3.25,.77,;3.25,2.31,;1.91,3.08,;.58,2.31,;.58,.77,;-.75,,;-.75,-1.54,;.58,-2.31,;.58,-3.85,;-2.09,.77,;-3.5,.14,;-4.53,1.29,;-3.76,2.62,;-4.38,4.03,;-5.91,4.19,;-2.25,2.3,;4.58,3.08,;5.91,2.31,;4.58,4.62,;5.91,3.85,)|	InChI=1S/C21H20F3N3O2/c1-13-4-2-3-5-17(13)27-18-10-15(21(22,23)24)6-7-16(18)19(25-20(27)29)26-9-8-14(11-26)12-28/h2-7,10,14,28H,8-9,11-12H2,1H3	FVTQRNSDNPBFKO-UHFFFAOYSA-N	508226	US11130759, Cpd. No. 537::US11046691, Compound 537::(R)-4-(3-(hydroxymethyl)pyrrolidin-1- yl)-1-(o-tolyl)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 537	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508226	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508226&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150232439	459093304							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072081	Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1CC[C@H](CO)C1)C(F)(F)F |r,wD:21.24,(4.58,,;4.58,-1.54,;5.91,-2.31,;5.91,-3.85,;4.58,-4.62,;3.25,-3.85,;3.25,-2.31,;1.91,-1.54,;1.91,,;3.25,.77,;3.25,2.31,;1.91,3.08,;.58,2.31,;.58,.77,;-.75,,;-.75,-1.54,;.58,-2.31,;.58,-3.85,;-2.09,.77,;-3.5,.14,;-4.53,1.29,;-3.76,2.62,;-4.38,4.03,;-5.91,4.19,;-2.25,2.3,;4.58,3.08,;5.91,2.31,;4.58,4.62,;5.91,3.85,)|	InChI=1S/C21H20F3N3O2/c1-13-4-2-3-5-17(13)27-18-10-15(21(22,23)24)6-7-16(18)19(25-20(27)29)26-9-8-14(11-26)12-28/h2-7,10,14,28H,8-9,11-12H2,1H3	FVTQRNSDNPBFKO-UHFFFAOYSA-N	508227	US11130759, Cpd. No. 538::US11046691, Compound 538::(S)-4-(3-(hydroxymethyl)pyrrolidin-1- yl)-1-(o-tolyl)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 538	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508227	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508227&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147577525	459093305							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072082	Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1CCC[C@@H]1CO)C(F)(F)F |r,wD:22.26,(3.89,-.13,;3.89,-1.67,;5.22,-2.44,;5.22,-3.98,;3.89,-4.75,;2.55,-3.98,;2.55,-2.44,;1.22,-1.67,;1.22,-.13,;2.55,.64,;2.55,2.18,;1.22,2.95,;-.11,2.18,;-.11,.64,;-1.45,-.13,;-1.45,-1.67,;-.11,-2.44,;-.11,-3.98,;-2.78,.64,;-4.19,.02,;-5.22,1.16,;-4.45,2.5,;-2.94,2.18,;-1.8,3.21,;-1.8,4.75,;3.89,2.95,;5.22,2.18,;3.89,4.49,;5.22,3.72,)|	InChI=1S/C21H20F3N3O2/c1-13-5-2-3-7-17(13)27-18-11-14(21(22,23)24)8-9-16(18)19(25-20(27)29)26-10-4-6-15(26)12-28/h2-3,5,7-9,11,15,28H,4,6,10,12H2,1H3	WXVKABGOLMDFOV-UHFFFAOYSA-N	508228	US11130759, Cpd. No. 539::US11046691, Compound 539::(R)-4-(2-(hydroxymethyl)pyrrolidin-1- yl)-1-(o-tolyl)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 539	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508228	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508228&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152343090	459093306							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072083	COc1cc(CNc2nc(=O)n(-c3ccccc3C)c3cc(ccc23)C(F)(F)F)on1 |(-7.99,2.51,;-7.32,1.13,;-5.79,1.29,;-4.76,.14,;-3.35,.77,;-2.02,,;-.68,.77,;.65,,;.65,-1.54,;1.98,-2.31,;1.98,-3.85,;3.32,-1.54,;4.65,-2.31,;4.65,-3.85,;5.99,-4.62,;7.32,-3.85,;7.32,-2.31,;5.99,-1.54,;5.99,,;3.32,,;4.65,.77,;4.65,2.31,;3.32,3.08,;1.98,2.31,;1.98,.77,;5.99,3.08,;7.32,2.31,;5.99,4.62,;7.32,3.85,;-3.51,2.3,;-5.02,2.62,)|	InChI=1S/C21H17F3N4O3/c1-12-5-3-4-6-16(12)28-17-9-13(21(22,23)24)7-8-15(17)19(26-20(28)29)25-11-14-10-18(30-2)27-31-14/h3-10H,11H2,1-2H3,(H,25,26,29)	LEWTXZPHNPATMQ-UHFFFAOYSA-N	508229	US11130759, Cpd. No. 540::US11046691, Compound 540::4(((3-methoxyisoxazol-5-yl)methyl)- amino)-1-(o-tolyl)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 540	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508229	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508229&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150925271	459093307							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072084	COc1cc(cc2n(-c3ccccc3)c(=O)nc(NCc3ccon3)c12)C(F)(F)F	InChI=1S/C20H15F3N4O3/c1-29-16-10-12(20(21,22)23)9-15-17(16)18(24-11-13-7-8-30-26-13)25-19(28)27(15)14-5-3-2-4-6-14/h2-10H,11H2,1H3,(H,24,25,28)	WWEJHZRCVCFHHN-UHFFFAOYSA-N	508230	US11130759, Cpd. No. 541::US11046691, Compound 541::4-((isoxazol-3-ylmethyl)amino)-5- methoxy-1-phenyl-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 541	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508230	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508230&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608230	459093308							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072085	COc1cc(CNc2nc(=O)n(-c3ccccc3)c3cc(cc(OC)c23)C(F)(F)F)on1	InChI=1S/C21H17F3N4O4/c1-30-16-9-12(21(22,23)24)8-15-18(16)19(25-11-14-10-17(31-2)27-32-14)26-20(29)28(15)13-6-4-3-5-7-13/h3-10H,11H2,1-2H3,(H,25,26,29)	WCILGXUZQRMJAG-UHFFFAOYSA-N	508231	US11130759, Cpd. No. 542::US11046691, Compound 542::5-methoxy-4(((3-methoxyisoxazol-5- yl)methyl)amino)-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 542	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508231	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508231&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152236183	459093309							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072086	COc1cc(cc2n(-c3ccccc3)c(=O)nc(NCc3cocn3)c12)C(F)(F)F	InChI=1S/C20H15F3N4O3/c1-29-16-8-12(20(21,22)23)7-15-17(16)18(24-9-13-10-30-11-25-13)26-19(28)27(15)14-5-3-2-4-6-14/h2-8,10-11H,9H2,1H3,(H,24,26,28)	YBNRJDRHAVKKFB-UHFFFAOYSA-N	508232	US11130759, Cpd. No. 543::US11046691, Compound 543::5-methoxy-4-((oxazol-4-ylmethyl)- amino)-1-phenyl-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 543	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508232	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508232&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608478	459093310							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072087	COc1cc(cc2n(-c3ccccc3)c(=O)nc(NCc3cnoc3)c12)C(F)(F)F	InChI=1S/C20H15F3N4O3/c1-29-16-8-13(20(21,22)23)7-15-17(16)18(24-9-12-10-25-30-11-12)26-19(28)27(15)14-5-3-2-4-6-14/h2-8,10-11H,9H2,1H3,(H,24,26,28)	RJBFHEWCCHNBMO-UHFFFAOYSA-N	508233	US11130759, Cpd. No. 544::US11046691, Compound 544::4-((isoxazol-4-ylmethyl)amino)-5- methoxy-1-phenyl-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 544	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508233&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608521	459093311							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072088	COc1cc(cc2n(-c3ccccc3)c(=O)nc(NCc3ncco3)c12)C(F)(F)F	InChI=1S/C20H15F3N4O3/c1-29-15-10-12(20(21,22)23)9-14-17(15)18(25-11-16-24-7-8-30-16)26-19(28)27(14)13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,25,26,28)	TVIVVCLDWFCQRI-UHFFFAOYSA-N	508234	US11130759, Cpd. No. 545::US11046691, Compound 545::5-methoxy-4-((oxazol-2-ylmethyl)- amino)-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 545	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508234	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508234&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608949	459093312							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072089	COc1cc(cc2n(-c3ccccc3)c(=O)nc(NCC(C)C)c12)C(F)(F)F	InChI=1S/C20H20F3N3O2/c1-12(2)11-24-18-17-15(9-13(20(21,22)23)10-16(17)28-3)26(19(27)25-18)14-7-5-4-6-8-14/h4-10,12H,11H2,1-3H3,(H,24,25,27)	BBPQUGYGIJMLTB-UHFFFAOYSA-N	508235	US11130759, Cpd. No. 546::US11046691, Compound 546::4-(isobutylamino)-5-methoxy-1-phenyl- 7-(trifluoromethyl)quinazolin-2(1H)- one::US11084798, Cpd No 546	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508235&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149743070	459093313							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072090	Cc1noc(C)c1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-2.82,-2.55,;-3.85,-1.4,;-5.38,-1.56,;-6.01,-.16,;-4.87,.87,;-4.87,2.41,;-3.53,.1,;-2.2,.87,;-.86,.1,;-.86,-1.44,;.47,-2.21,;.47,-3.75,;1.8,-1.44,;3.14,-2.21,;3.14,-3.75,;4.47,-4.52,;5.8,-3.75,;5.8,-2.21,;4.47,-1.44,;4.47,.1,;1.8,.1,;3.14,.87,;3.14,2.41,;1.8,3.18,;.47,2.41,;.47,.87,;4.47,3.18,;6.01,3.18,;5.24,4.52,)|	InChI=1S/C22H19ClN4O2/c1-12-20(13(2)29-26-12)24-21-16-10-9-15(14-7-8-14)11-19(16)27(22(28)25-21)18-6-4-3-5-17(18)23/h3-6,9-11,14H,7-8H2,1-2H3,(H,24,25,28)	GEOPIFXMVAPBPU-UHFFFAOYSA-N	508236	US11130759, Cpd. No. 547::US11046691, Compound 547::1-(2-chlorophenyl)-7-cyclopropyl-4- ((3,5-dimethylisoxazol-4-yl)amino)- quinazolin-2(1H)-one::US11084798, Cpd No 547	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508236	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508236&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608482	459093314							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072091	Cc1nocc1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-2.82,-2.55,;-3.85,-1.4,;-5.38,-1.56,;-6.01,-.16,;-4.87,.87,;-3.53,.1,;-2.2,.87,;-.86,.1,;-.86,-1.44,;.47,-2.21,;.47,-3.75,;1.8,-1.44,;3.14,-2.21,;3.14,-3.75,;4.47,-4.52,;5.8,-3.75,;5.8,-2.21,;4.47,-1.44,;4.47,.1,;1.8,.1,;3.14,.87,;3.14,2.41,;1.8,3.18,;.47,2.41,;.47,.87,;4.47,3.18,;6.01,3.18,;5.24,4.52,)|	InChI=1S/C21H17ClN4O2/c1-12-17(11-28-25-12)23-20-15-9-8-14(13-6-7-13)10-19(15)26(21(27)24-20)18-5-3-2-4-16(18)22/h2-5,8-11,13H,6-7H2,1H3,(H,23,24,27)	AFXATVVZVBUSON-UHFFFAOYSA-N	508237	US11130759, Cpd. No. 548::US11046691, Compound 548::1-(2-chlorophenyl)-7-cyclopropyl-4- ((3-methylisoxazol-4- yl)amino)quinazolin-2(1H)-one::US11084798, Cpd No 548	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508237	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508237&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			146935782	459093315							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072092	Cc1oncc1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-4.87,2.41,;-4.87,.87,;-6.01,-.16,;-5.38,-1.56,;-3.85,-1.4,;-3.53,.1,;-2.2,.87,;-.86,.1,;-.86,-1.44,;.47,-2.21,;.47,-3.75,;1.8,-1.44,;3.14,-2.21,;3.14,-3.75,;4.47,-4.52,;5.8,-3.75,;5.8,-2.21,;4.47,-1.44,;4.47,.1,;1.8,.1,;3.14,.87,;3.14,2.41,;1.8,3.18,;.47,2.41,;.47,.87,;4.47,3.18,;6.01,3.18,;5.24,4.52,)|	InChI=1S/C21H17ClN4O2/c1-12-17(11-23-28-12)24-20-15-9-8-14(13-6-7-13)10-19(15)26(21(27)25-20)18-5-3-2-4-16(18)22/h2-5,8-11,13H,6-7H2,1H3,(H,24,25,27)	WUPGEXXIPNVFQY-UHFFFAOYSA-N	508238	US11130759, Cpd. No. 549::US11046691, Compound 549::1-(2-chlorophenyl)-7-cyclopropyl-4- ((5-methylisoxazol-4- yl)amino)quinazolin-2(1H)-one::US11084798, Cpd No 549	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508238	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508238&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608245	459093316							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072093	CN(CC1CC1)c1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-2,2.41,;-2,.87,;-3.33,.1,;-4.67,.87,;-5.44,2.21,;-6.21,.87,;-.67,.1,;-.67,-1.44,;.67,-2.21,;.67,-3.75,;2,-1.44,;3.33,-2.21,;3.33,-3.75,;4.67,-4.52,;6,-3.75,;6,-2.21,;4.67,-1.44,;4.67,.1,;2,.1,;3.33,.87,;3.33,2.41,;2,3.18,;.67,2.41,;.67,.87,;4.67,3.18,;6.21,3.18,;5.44,4.52,)|	InChI=1S/C22H22ClN3O/c1-25(13-14-6-7-14)21-17-11-10-16(15-8-9-15)12-20(17)26(22(27)24-21)19-5-3-2-4-18(19)23/h2-5,10-12,14-15H,6-9,13H2,1H3	DBIWMXGRVPDYFS-UHFFFAOYSA-N	508239	US11130759, Cpd. No. 550::US11046691, Compound 550::1-(2-chlorophenyl)-7-cyclopropyl-4- ((cyclopropylmethyl)(methyl)amino)qui nazolin-2(1H)-one::US11084798, Cpd No 550	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508239	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508239&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608469	459093317							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072094	Cc1ccccc1-n1c2cc(OC(F)(F)F)c(cc2c(NCC2CC2)nc1=O)C#N |(4.1,-.77,;4.1,-2.31,;5.44,-3.08,;5.44,-4.62,;4.1,-5.39,;2.77,-4.62,;2.77,-3.08,;1.44,-2.31,;1.44,-.77,;2.77,,;2.77,1.54,;4.1,2.31,;5.44,1.54,;6.77,2.31,;5.44,,;5.44,3.08,;1.44,2.31,;.1,1.54,;.1,,;-1.23,-.77,;-2.56,,;-3.9,-.77,;-5.23,,;-6,1.33,;-6.77,,;-1.23,-2.31,;.1,-3.08,;.1,-4.62,;1.44,3.85,;1.44,5.39,)|	InChI=1S/C21H17F3N4O2/c1-12-4-2-3-5-16(12)28-17-9-18(30-21(22,23)24)14(10-25)8-15(17)19(27-20(28)29)26-11-13-6-7-13/h2-5,8-9,13H,6-7,11H2,1H3,(H,26,27,29)	AOWGNDNWDJCXJQ-UHFFFAOYSA-N	508240	US11130759, Cpd. No. 551::US11046691, Compound 551::4-((cyclopropylmethyl)amino)-2-oxo-1- (o-tolyl)-7-(trifluoromethoxy)-1,2- dihydroquinazoline-6-carbonitrile::US11084798, Cpd No 551	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508240	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508240&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608945	459093318							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072095	Cc1cc2c(NCC3CC3)nc(=O)n(-c3ccccc3C)c2cc1OC(F)(F)F |(1.44,4.62,;1.44,3.08,;.1,2.31,;.1,.77,;-1.23,,;-2.56,.77,;-3.9,,;-5.23,.77,;-6,2.1,;-6.77,.77,;-1.23,-1.54,;.1,-2.31,;.1,-3.85,;1.44,-1.54,;2.77,-2.31,;2.77,-3.85,;4.1,-4.62,;5.44,-3.85,;5.44,-2.31,;4.1,-1.54,;4.1,,;1.44,,;2.77,.77,;2.77,2.31,;4.1,3.08,;5.44,2.31,;6.77,3.08,;5.44,.77,;5.44,3.85,)|	InChI=1S/C21H20F3N3O2/c1-12-5-3-4-6-16(12)27-17-10-18(29-21(22,23)24)13(2)9-15(17)19(26-20(27)28)25-11-14-7-8-14/h3-6,9-10,14H,7-8,11H2,1-2H3,(H,25,26,28)	SBILUWRWPFRWMW-UHFFFAOYSA-N	508241	US11130759, Cpd. No. 552::US11046691, Compound 554::4-((cyclopropylmethyl)amino)-6- methyl-1-(o-tolyl)-7- (trifluoromethoxy)-quinazolin-2(1H)- one::US11046691, Compound 552::US11084798, Cpd No 552	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508241&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608268	459093319							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072096	CNc1nc(=O)n(-c2ccccc2C)c2cc(OC(F)(F)F)c(C)cc12 |(-5.33,,;-4,.77,;-2.67,,;-2.67,-1.54,;-1.33,-2.31,;-1.33,-3.85,;,-1.54,;1.33,-2.31,;1.33,-3.85,;2.67,-4.62,;4,-3.85,;4,-2.31,;2.67,-1.54,;2.67,,;;1.33,.77,;1.33,2.31,;2.67,3.08,;4,2.31,;5.33,3.08,;4,.77,;4,3.85,;,3.08,;,4.62,;-1.33,2.31,;-1.33,.77,)|	InChI=1S/C18H16F3N3O2/c1-10-6-4-5-7-13(10)24-14-9-15(26-18(19,20)21)11(2)8-12(14)16(22-3)23-17(24)25/h4-9H,1-3H3,(H,22,23,25)	DGXBHXLDEWCQDX-UHFFFAOYSA-N	508242	US11130759, Cpd. No. 553::US11046691, Compound 553::6-methyl-4-(methylamino)-1-(o-tolyl)- 7-(trifluoromethoxy)quinazolin-2(1H)- one::US11084798, Cpd No 553	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508242	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508242&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150029230	459093320							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072097	Cc1cc2c(NCC3CC3)nc(=O)n(-c3ccccc3)c2cc1OC(F)(F)F	InChI=1S/C20H18F3N3O2/c1-12-9-15-16(10-17(12)28-20(21,22)23)26(14-5-3-2-4-6-14)19(27)25-18(15)24-11-13-7-8-13/h2-6,9-10,13H,7-8,11H2,1H3,(H,24,25,27)	MKDQLKOEHMQZBC-UHFFFAOYSA-N	512218	US11130759, Cpd. No. 554::US11084798, Cpd No 554::4-((cyclopropylmethyl)amino)-6- methyl-1-phenyl-7-(trifluoromethoxy)- quinazolin-2(1H)-one	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=512218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=512218&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608775	459629467							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072098	Cc1ccccc1-n1c2cc(OC(F)(F)F)c(Br)cc2c(NCC2CC2)nc1=O |(4.1,,;4.1,-1.54,;5.44,-2.31,;5.44,-3.85,;4.1,-4.62,;2.77,-3.85,;2.77,-2.31,;1.44,-1.54,;1.44,,;2.77,.77,;2.77,2.31,;4.1,3.08,;5.44,2.31,;6.77,3.08,;5.44,.77,;5.44,3.85,;1.44,3.08,;1.44,4.62,;.1,2.31,;.1,.77,;-1.23,,;-2.56,.77,;-3.9,,;-5.23,.77,;-6,2.1,;-6.77,.77,;-1.23,-1.54,;.1,-2.31,;.1,-3.85,)|	InChI=1S/C20H17BrF3N3O2/c1-11-4-2-3-5-15(11)27-16-9-17(29-20(22,23)24)14(21)8-13(16)18(26-19(27)28)25-10-12-6-7-12/h2-5,8-9,12H,6-7,10H2,1H3,(H,25,26,28)	LRNRQUGYGHISQT-UHFFFAOYSA-N	508244	US11130759, Cpd. No. 555::US11046691, Compound 555::6-bromo-4- ((cyclopropylmethyl)amino)-1-(o- tolyl)-7-(trifluoromethoxy)-quinazolin- 2(1H)-one::US11084798, Cpd No 555	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508244	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508244&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608914	459093321							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072099	CNc1nc(=O)n(-c2ccccc2C)c2cc(OC(F)(F)F)c(Br)cc12 |(-5.33,,;-4,.77,;-2.67,,;-2.67,-1.54,;-1.33,-2.31,;-1.33,-3.85,;,-1.54,;1.33,-2.31,;1.33,-3.85,;2.67,-4.62,;4,-3.85,;4,-2.31,;2.67,-1.54,;2.67,,;;1.33,.77,;1.33,2.31,;2.67,3.08,;4,2.31,;5.33,3.08,;4,.77,;4,3.85,;,3.08,;,4.62,;-1.33,2.31,;-1.33,.77,)|	InChI=1S/C17H13BrF3N3O2/c1-9-5-3-4-6-12(9)24-13-8-14(26-17(19,20)21)11(18)7-10(13)15(22-2)23-16(24)25/h3-8H,1-2H3,(H,22,23,25)	PCDGSTHCUOXEKI-UHFFFAOYSA-N	508245	US11130759, Cpd. No. 556::US11046691, Compound 556::6-bromo-4-(methylamino)-1-(o-tolyl)- 7-(trifluoromethoxy)quinazolin-2(1H)- one::US11084798, Cpd No 556	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508245&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609023	459093322							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072100	FC(F)(F)Oc1cc2n(-c3ccccc3)c(=O)nc(NCC3CC3)c2cc1Br	InChI=1S/C19H15BrF3N3O2/c20-14-8-13-15(9-16(14)28-19(21,22)23)26(12-4-2-1-3-5-12)18(27)25-17(13)24-10-11-6-7-11/h1-5,8-9,11H,6-7,10H2,(H,24,25,27)	NCPBZLXMXQJWGH-UHFFFAOYSA-N	508246	US11130759, Cpd. No. 557::US11046691, Compound 557::6-bromo-4- ((cyclopropylmethyl)amino)-1-phenyl- 7-(trifluoromethoxy)-quinazolin-2(1H)- one::US11084798, Cpd No 557	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508246	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508246&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151172587	459093323							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072101	COc1cc(cc2n(-c3ccccc3)c(=O)nc(N[C@@H]3C[C@@H]3F)c12)C(F)(F)F |r|	InChI=1S/C19H15F4N3O2/c1-28-15-8-10(19(21,22)23)7-14-16(15)17(24-13-9-12(13)20)25-18(27)26(14)11-5-3-2-4-6-11/h2-8,12-13H,9H2,1H3,(H,24,25,27)	YVFPRZVCQUZGFQ-UHFFFAOYSA-N	508247	US11130759, Cpd. No. 558::US11046691, Compound 558::4-(((1R,2S)-2- fluorocyclopropyl)amino)-5-methoxy- 1-phenyl-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 558	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508247	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508247&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152589774	459093324							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072102	COc1cc(cc2n(-c3ccccc3)c(=O)nc(N[C@H]3C[C@H]3F)c12)C(F)(F)F |r|	InChI=1S/C19H15F4N3O2/c1-28-15-8-10(19(21,22)23)7-14-16(15)17(24-13-9-12(13)20)25-18(27)26(14)11-5-3-2-4-6-11/h2-8,12-13H,9H2,1H3,(H,24,25,27)	YVFPRZVCQUZGFQ-UHFFFAOYSA-N	508248	US11130759, Cpd. No. 559::US11046691, Compound 559::4-(((1S,2R)-2- fluorocyclopropyl)amino)-5-methoxy- 1-phenyl-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 559	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508248	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508248&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152589773	459093325							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072103	COc1cc(cc2n(-c3ccccc3)c(=O)nc(N)c12)C(F)(F)F	InChI=1S/C16H12F3N3O2/c1-24-12-8-9(16(17,18)19)7-11-13(12)14(20)21-15(23)22(11)10-5-3-2-4-6-10/h2-8H,1H3,(H2,20,21,23)	RFIXMQALDMTVDE-UHFFFAOYSA-N	508249	US11130759, Cpd. No. 560::US11046691, Compound 560::4-amino-5-methoxy-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 560	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508249	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508249&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151704805	459093326							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072104	COc1cc(cc2n(-c3ccccc3)c(=O)nc(N[C@H]3C[C@@H]3F)c12)C(F)(F)F |r|	InChI=1S/C19H15F4N3O2/c1-28-15-8-10(19(21,22)23)7-14-16(15)17(24-13-9-12(13)20)25-18(27)26(14)11-5-3-2-4-6-11/h2-8,12-13H,9H2,1H3,(H,24,25,27)	YVFPRZVCQUZGFQ-UHFFFAOYSA-N	508250	US11130759, Cpd. No. 761::US11046691, Compound 761::4-(((trans)-2-fluorocyclopropyl)amino)- 5-methoxy-1-phenyl-7- (trifluoromethyl)-quinazolin-2(1H)-one::US11046691, Compound 561::US11084798, Cpd No 561	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508250&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608856	459093327							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072105	FC(F)(F)c1nccnc1-n1c2cc(ccc2c(NCC2CC2)nc1=O)C1CC1 |(4.74,1.75,;4.72,.21,;3.18,.23,;6.26,.19,;4.7,-1.33,;6,-2.21,;6,-3.75,;4.67,-4.52,;3.33,-3.75,;3.33,-2.21,;2,-1.44,;2,.1,;3.33,.87,;3.33,2.41,;2,3.18,;.67,2.41,;.67,.87,;-.67,.1,;-2,.87,;-3.33,.1,;-4.67,.87,;-5.44,2.21,;-6.21,.87,;-.67,-1.44,;.67,-2.21,;.67,-3.75,;4.67,3.18,;6.21,3.18,;5.44,4.52,)|	InChI=1S/C20H18F3N5O/c21-20(22,23)16-18(25-8-7-24-16)28-15-9-13(12-3-4-12)5-6-14(15)17(27-19(28)29)26-10-11-1-2-11/h5-9,11-12H,1-4,10H2,(H,26,27,29)	SQMWICVPIVVBBV-UHFFFAOYSA-N	508251	US11130759, Cpd. No. 562::US11046691, Compound 562::7-cyclopropyl-4- (cyclopropylmethylamino)-1-(3- (trifluoromethyl)pyrazin-2-yl)- quinazolin-2(1H)-one::US11084798, Cpd No 562	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508251&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151889857	459093328							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072106	CNc1nc(=O)n(-c2nccnc2C(F)(F)F)c2cc(ccc12)C1CC1 |(-4.77,.1,;-3.44,.87,;-2.1,.1,;-2.1,-1.44,;-.77,-2.21,;-.77,-3.75,;.56,-1.44,;1.9,-2.21,;1.9,-3.75,;3.23,-4.52,;4.56,-3.75,;4.56,-2.21,;3.27,-1.33,;3.29,.21,;3.31,1.75,;1.75,.23,;4.83,.19,;.56,.1,;1.9,.87,;1.9,2.41,;.56,3.18,;-.77,2.41,;-.77,.87,;3.23,3.18,;4.77,3.18,;4,4.52,)|	InChI=1S/C17H14F3N5O/c1-21-14-11-5-4-10(9-2-3-9)8-12(11)25(16(26)24-14)15-13(17(18,19)20)22-6-7-23-15/h4-9H,2-3H2,1H3,(H,21,24,26)	YQLOGJMLERAFLT-UHFFFAOYSA-N	508252	US11130759, Cpd. No. 563::US11046691, Compound 563::7-cyclopropyl-4-(methylamino)-1-(3- (trifluoromethyl)pyrazin-2- yl)quinazolin-2(1H)-one::US11084798, Cpd No 563	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508252&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152565823	459093329							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072107	COc1cc(cc2n(-c3ccccc3)c(=O)nc(N[C@H]3CC[C@@H]3O)c12)C(F)(F)F |r|	InChI=1S/C20H18F3N3O3/c1-29-16-10-11(20(21,22)23)9-14-17(16)18(24-13-7-8-15(13)27)25-19(28)26(14)12-5-3-2-4-6-12/h2-6,9-10,13,15,27H,7-8H2,1H3,(H,24,25,28)	PXISDPBJTPGEAR-UHFFFAOYSA-N	508253	US11130759, Cpd. No. 564::US11046691, Compound 564::4-(((trans)-2- hydroxycyclobutyl)amino)-5-methoxy- 1-phenyl-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 564	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508253	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508253&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154929345	459093330							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072108	COc1cc(cc2n(-c3ccccc3)c(=O)nc(NC[C@H](C)O)c12)C(F)(F)F |r|	InChI=1S/C19H18F3N3O3/c1-11(26)10-23-17-16-14(8-12(19(20,21)22)9-15(16)28-2)25(18(27)24-17)13-6-4-3-5-7-13/h3-9,11,26H,10H2,1-2H3,(H,23,24,27)	AKYUIKUOEGVNFQ-UHFFFAOYSA-N	508254	US11130759, Cpd. No. 565::US11046691, Compound 565::(S)-4-((2-hydroxypropyl)amino)-5- methoxy-1-phenyl-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 565	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508254&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149660109	459093331							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072109	COCCNc1nc(=O)n(-c2ccccc2)c2cc(cc(OC)c12)C(F)(F)F	InChI=1S/C19H18F3N3O3/c1-27-9-8-23-17-16-14(10-12(19(20,21)22)11-15(16)28-2)25(18(26)24-17)13-6-4-3-5-7-13/h3-7,10-11H,8-9H2,1-2H3,(H,23,24,26)	CQFYAZYQFAHZLN-UHFFFAOYSA-N	508255	US11130759, Cpd. No. 566::US11046691, Compound 566::5-methoxy-4-((2-methoxyethyl)amino)- 1-phenyl-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 566	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508255&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608819	459093332							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072110	COc1cc(cc2n(-c3ccccc3)c(=O)nc(NCCO)c12)C(F)(F)F	InChI=1S/C18H16F3N3O3/c1-27-14-10-11(18(19,20)21)9-13-15(14)16(22-7-8-25)23-17(26)24(13)12-5-3-2-4-6-12/h2-6,9-10,25H,7-8H2,1H3,(H,22,23,26)	HSZZCOYJYPOPBB-UHFFFAOYSA-N	508256	US11130759, Cpd. No. 567::US11046691, Compound 567::4-((2-hydroxyethyl)amino)-5-methoxy- 1-phenyl-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 567	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508256&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608729	459093333							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072111	COc1cc(cc2n(-c3ccccc3)c(=O)nc(NCC3CC3)c12)C(F)(F)F	InChI=1S/C20H18F3N3O2/c1-28-16-10-13(20(21,22)23)9-15-17(16)18(24-11-12-7-8-12)25-19(27)26(15)14-5-3-2-4-6-14/h2-6,9-10,12H,7-8,11H2,1H3,(H,24,25,27)	HTFOTNOPNBOLTB-UHFFFAOYSA-N	508257	US11130759, Cpd. No. 568::US11046691, Compound 568::4-((cyclopropylmethyl)amino)-5- methoxy-1-phenyl-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 568	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508257&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608573	459093334							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072112	F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2)c2cc(cc(F)c12)C(F)(F)F |r|	InChI=1S/C18H12F5N3O/c19-11-8-13(11)24-16-15-12(20)6-9(18(21,22)23)7-14(15)26(17(27)25-16)10-4-2-1-3-5-10/h1-7,11,13H,8H2,(H,24,25,27)	KGYQTXXQJRHQSY-UHFFFAOYSA-N	508258	US11130759, Cpd. No. 569::US11046691, Compound 569::5-fluoro-4-((trans-2-fluorocyclopropyl)- amino)-1-phenyl-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 569	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508258&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608658	459093335							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072113	C[C@@H](O)CNc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(Cl)cc12 |r,wU:1.1,(-6.08,,;-4.74,.77,;-4.74,2.31,;-3.41,,;-2.08,.77,;-.74,,;-.74,-1.54,;.59,-2.31,;.59,-3.85,;1.92,-1.54,;3.26,-2.31,;3.26,-3.85,;4.59,-4.62,;5.92,-3.85,;5.92,-2.31,;4.59,-1.54,;4.59,,;1.92,,;3.26,.77,;3.26,2.31,;4.59,3.08,;6.08,3.48,;4.99,4.57,;1.92,3.08,;1.92,4.62,;.59,2.31,;.59,.77,)|	InChI=1S/C20H19Cl2N3O2/c1-11(26)10-23-19-14-8-16(22)13(12-6-7-12)9-18(14)25(20(27)24-19)17-5-3-2-4-15(17)21/h2-5,8-9,11-12,26H,6-7,10H2,1H3,(H,23,24,27)	VJIZTBRBRIBXDW-UHFFFAOYSA-N	508259	US11130759, Cpd. No. 570::US11046691, Compound 570::(R)-6-chloro-1-(2-chlorophenyl)-7- cyclopropyl-4((2-hydroxypropyl)- amino)-quinazolin-2(1H)-one::US11084798, Cpd No 570	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508259&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152141713	459093336							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072114	C[C@H](O)CNc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(Cl)cc12 |r,wD:1.1,(-6.08,,;-4.74,.77,;-4.74,2.31,;-3.41,,;-2.08,.77,;-.74,,;-.74,-1.54,;.59,-2.31,;.59,-3.85,;1.92,-1.54,;3.26,-2.31,;3.26,-3.85,;4.59,-4.62,;5.92,-3.85,;5.92,-2.31,;4.59,-1.54,;4.59,,;1.92,,;3.26,.77,;3.26,2.31,;4.59,3.08,;6.08,3.48,;4.99,4.57,;1.92,3.08,;1.92,4.62,;.59,2.31,;.59,.77,)|	InChI=1S/C20H19Cl2N3O2/c1-11(26)10-23-19-14-8-16(22)13(12-6-7-12)9-18(14)25(20(27)24-19)17-5-3-2-4-15(17)21/h2-5,8-9,11-12,26H,6-7,10H2,1H3,(H,23,24,27)	VJIZTBRBRIBXDW-UHFFFAOYSA-N	508260	US11130759, Cpd. No. 571::US11046691, Compound 571::(S)-6-chloro-1-(2-chlorophenyl)-7- cyclopropyl-4((2-hydroxypropyl)- amino)-quinazolin-2(1H)-one::US11084798, Cpd No 571	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508260	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508260&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152141714	459093337							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072115	COCCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-6.5,2.39,;-6.77,.87,;-5.44,.1,;-4.1,.87,;-2.77,.1,;-1.44,.87,;-.1,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-1.44,;3.9,-2.21,;3.9,-3.75,;5.23,-4.52,;6.57,-3.75,;6.57,-2.21,;5.23,-1.44,;5.23,.1,;2.56,.1,;3.9,.87,;3.9,2.41,;2.56,3.18,;1.23,2.41,;1.23,.87,;5.23,3.18,;6.77,3.18,;6,4.52,)|	InChI=1S/C21H22ClN3O2/c1-27-12-4-11-23-20-16-10-9-15(14-7-8-14)13-19(16)25(21(26)24-20)18-6-3-2-5-17(18)22/h2-3,5-6,9-10,13-14H,4,7-8,11-12H2,1H3,(H,23,24,26)	QIWYNLBFCVZXAW-UHFFFAOYSA-N	508261	US11130759, Cpd. No. 572::US11046691, Compound 572::1-(2-chlorophenyl)-7-cyclopropyl-4- ((3-methoxypropyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 572	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508261	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508261&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608211	459093338							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072116	OCCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-6.77,.87,;-5.44,.1,;-4.1,.87,;-2.77,.1,;-1.44,.87,;-.1,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-1.44,;3.9,-2.21,;3.9,-3.75,;5.23,-4.52,;6.57,-3.75,;6.57,-2.21,;5.23,-1.44,;5.23,.1,;2.56,.1,;3.9,.87,;3.9,2.41,;2.56,3.18,;1.23,2.41,;1.23,.87,;5.23,3.18,;6.77,3.18,;6,4.52,)|	InChI=1S/C20H20ClN3O2/c21-16-4-1-2-5-17(16)24-18-12-14(13-6-7-13)8-9-15(18)19(23-20(24)26)22-10-3-11-25/h1-2,4-5,8-9,12-13,25H,3,6-7,10-11H2,(H,22,23,26)	BLDOFYAKJPVTFK-UHFFFAOYSA-N	508262	US11130759, Cpd. No. 573::US11046691, Compound 573::1-(2-chlorophenyl)-7-cyclopropyl-4- ((3-hydroxypropyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 573	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508262	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508262&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608689	459093339							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072117	COCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-7.28,1.09,;-6.1,.1,;-4.77,.87,;-3.44,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;3.23,-3.75,;4.56,-4.52,;5.9,-3.75,;5.9,-2.21,;4.56,-1.44,;4.56,.1,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,)|	InChI=1S/C20H20ClN3O2/c1-26-11-10-22-19-15-9-8-14(13-6-7-13)12-18(15)24(20(25)23-19)17-5-3-2-4-16(17)21/h2-5,8-9,12-13H,6-7,10-11H2,1H3,(H,22,23,25)	SAIKNVSKLNKRDM-UHFFFAOYSA-N	508263	US11130759, Cpd. No. 606::US11046691, Compound 574::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-methoxyethyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 606	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508263&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608626	459093340							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072118	OCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-6.1,.1,;-4.77,.87,;-3.44,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;3.23,-3.75,;4.56,-4.52,;5.9,-3.75,;5.9,-2.21,;4.56,-1.44,;4.56,.1,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,)|	InChI=1S/C19H18ClN3O2/c20-15-3-1-2-4-16(15)23-17-11-13(12-5-6-12)7-8-14(17)18(21-9-10-24)22-19(23)25/h1-4,7-8,11-12,24H,5-6,9-10H2,(H,21,22,25)	UVRCNALCQMXMDW-UHFFFAOYSA-N	508264	US11130759, Cpd. No. 607::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-hydroxyethyl)amino)quinazolin- 2(1H)-one::US11046691, Compound 607::US11046691, Compound 575::US11084798, Cpd No 607	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508264&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608389	459093341							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072119	C[C@@H](CO)Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |r,wU:1.0,(-3.44,-1.44,;-3.44,.1,;-4.77,.87,;-6.1,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;3.23,-3.75,;4.56,-4.52,;5.9,-3.75,;5.9,-2.21,;4.56,-1.44,;4.56,.1,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,)|	InChI=1S/C20H20ClN3O2/c1-12(11-25)22-19-15-9-8-14(13-6-7-13)10-18(15)24(20(26)23-19)17-5-3-2-4-16(17)21/h2-5,8-10,12-13,25H,6-7,11H2,1H3,(H,22,23,26)	QTXFHIRKQPYFMB-UHFFFAOYSA-N	508265	US11130759, Cpd. No. 576::US11046691, Compound 576::1-(2-chlorophenyl)-7-cyclopropyl-4- (((S)-1-hydroxypropan-2-yl)amino)- quinazolin-2(1H)-one::US11084798, Cpd No 576	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508265	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508265&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608838	459093342							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072120	C[C@H](CO)Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |r,wD:1.0,(-3.44,-1.44,;-3.44,.1,;-4.77,.87,;-6.1,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;3.23,-3.75,;4.56,-4.52,;5.9,-3.75,;5.9,-2.21,;4.56,-1.44,;4.56,.1,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,)|	InChI=1S/C20H20ClN3O2/c1-12(11-25)22-19-15-9-8-14(13-6-7-13)10-18(15)24(20(26)23-19)17-5-3-2-4-16(17)21/h2-5,8-10,12-13,25H,6-7,11H2,1H3,(H,22,23,26)	QTXFHIRKQPYFMB-UHFFFAOYSA-N	508266	US11130759, Cpd. No. 577::US11046691, Compound 577::1-(2-chlorophenyl)-7-cyclopropyl-4- (((R)-1-hydroxypropan-2-yl)amino)- quinazolin-2(1H)-one::US11084798, Cpd No 577	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508266	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508266&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609024	459093343							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072121	CC1(CCC1)Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-5.44,.87,;-4.1,.1,;-5.19,-.99,;-4.1,-2.07,;-3.02,-.99,;-2.77,.87,;-1.44,.1,;-1.44,-1.44,;-.1,-2.21,;-.1,-3.75,;1.23,-1.44,;2.56,-2.21,;2.56,-3.75,;3.9,-4.52,;5.23,-3.75,;5.23,-2.21,;3.9,-1.44,;3.9,.1,;1.23,.1,;2.56,.87,;2.56,2.41,;1.23,3.18,;-.1,2.41,;-.1,.87,;3.9,3.18,;5.44,3.18,;4.67,4.52,)|	InChI=1S/C22H22ClN3O/c1-22(11-4-12-22)25-20-16-10-9-15(14-7-8-14)13-19(16)26(21(27)24-20)18-6-3-2-5-17(18)23/h2-3,5-6,9-10,13-14H,4,7-8,11-12H2,1H3,(H,24,25,27)	YACHWVMSJOMZOL-UHFFFAOYSA-N	508267	US11130759, Cpd. No. 578::US11046691, Compound 578::1-(2-chlorophenyl)-7-cyclopropyl-4- methylcyclobutyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 578	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508267	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508267&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608870	459093344							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072122	Nc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(Cl)cc12 |(-4.1,.77,;-2.77,,;-2.77,-1.54,;-1.44,-2.31,;-1.44,-3.85,;-.1,-1.54,;1.23,-2.31,;1.23,-3.85,;2.56,-4.62,;3.9,-3.85,;3.9,-2.31,;2.56,-1.54,;2.56,,;-.1,,;1.23,.77,;1.23,2.31,;2.56,3.08,;4.1,3.08,;3.33,4.41,;-.1,3.08,;-.1,4.62,;-1.44,2.31,;-1.44,.77,)|	InChI=1S/C17H13Cl2N3O/c18-12-3-1-2-4-14(12)22-15-8-10(9-5-6-9)13(19)7-11(15)16(20)21-17(22)23/h1-4,7-9H,5-6H2,(H2,20,21,23)	GJQZFGBAZNAJMM-UHFFFAOYSA-N	508268	US11130759, Cpd. No. 579::US11046691, Compound 579::4-amino-6-chloro-1-(2-chlorophenyl)-7- cyclopropylquinazolin-2(1H)-one::US11084798, Cpd No 579	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508268	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508268&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150301317	459093345							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072123	Nc1nc(=O)n(-c2cccnc2C(F)(F)F)c2cc(ccc12)C1CC1 |(-4.1,.87,;-2.77,.1,;-2.77,-1.44,;-1.44,-2.21,;-1.44,-3.75,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-4.52,;3.9,-3.75,;3.9,-2.21,;2.56,-1.38,;2.56,.16,;2.56,1.7,;4.1,.16,;1.02,.16,;-.1,.1,;1.23,.87,;1.23,2.41,;-.1,3.18,;-1.44,2.41,;-1.44,.87,;2.56,3.18,;4.1,3.18,;3.33,4.52,)|	InChI=1S/C17H13F3N4O/c18-17(19,20)14-12(2-1-7-22-14)24-13-8-10(9-3-4-9)5-6-11(13)15(21)23-16(24)25/h1-2,5-9H,3-4H2,(H2,21,23,25)	YTAOZVRUHOHVHK-UHFFFAOYSA-N	508269	US11130759, Cpd. No. 580::US11046691, Compound 580::4-amino-7-cyclopropyl-1-(2-(trifluoro- methyl)pyridin-3-yl)quinazolin-2(1H)- one::US11084798, Cpd No 580	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508269	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508269&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152578762	459093346							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072124	Nc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |(-4.67,1.18,;-3.33,.41,;-3.33,-1.13,;-2,-1.9,;-2,-3.44,;-.67,-1.13,;.67,-1.9,;.67,-3.44,;2,-4.21,;3.33,-3.44,;3.33,-1.9,;2,-1.13,;2,.41,;-.67,.41,;.67,1.18,;.67,2.72,;2,3.49,;3.33,2.72,;4.67,3.49,;3.33,1.18,;2.94,4.21,;-.67,3.49,;-2,2.72,;-2,1.18,)|	InChI=1S/C15H9ClF3N3O2/c16-10-3-1-2-4-11(10)22-12-7-8(24-15(17,18)19)5-6-9(12)13(20)21-14(22)23/h1-7H,(H2,20,21,23)	CKGFBRUENCOSRY-UHFFFAOYSA-N	508270	US11130759, Cpd. No. 581::US11046691, Compound 581::4-amino-1-(2-chlorophenyl)-7- (trifluoromethoxy)quinazolin-2(1H)- one::US11084798, Cpd No 581	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508270	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508270&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147238184	459093347							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072125	O[C@H]1CC[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |r,wU:1.0,wD:4.5,(-3.46,-2.72,;-4.23,-1.38,;-5.71,-.99,;-5.32,.5,;-3.83,.1,;-2.49,.87,;-1.16,.1,;-1.16,-1.44,;.17,-2.21,;.17,-3.75,;1.51,-1.44,;2.84,-2.21,;2.84,-3.75,;4.17,-4.52,;5.51,-3.75,;5.51,-2.21,;4.17,-1.44,;4.17,.1,;1.51,.1,;2.84,.87,;2.84,2.41,;1.51,3.18,;.17,2.41,;.17,.87,;4.17,3.18,;5.71,3.18,;4.94,4.52,)|	InChI=1S/C21H20ClN3O2/c22-15-3-1-2-4-17(15)25-18-11-13(12-5-6-12)7-8-14(18)20(24-21(25)27)23-16-9-10-19(16)26/h1-4,7-8,11-12,16,19,26H,5-6,9-10H2,(H,23,24,27)	KTESLFWHFREMJK-UHFFFAOYSA-N	508271	US11130759, Cpd. No. 582::US11046691, Compound 582::1-(2-chlorophenyl)-7-cyclopropyl-4- (((trans)-2-hydroxycyclobutyl)amino)- quinazolin-2(1H)-one::US11084798, Cpd No 582	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508271	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508271&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608226	459093348							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072126	Clc1ccccc1-n1c2cc(C3CC3)c(Br)cc2c(Nc2cnoc2)nc1=O |(4.48,,;4.48,-1.54,;5.81,-2.31,;5.81,-3.85,;4.48,-4.62,;3.14,-3.85,;3.14,-2.31,;1.81,-1.54,;1.81,,;3.14,.77,;3.14,2.31,;4.48,3.08,;5.96,3.48,;4.87,4.57,;1.81,3.08,;1.81,4.62,;.47,2.31,;.47,.77,;-.86,,;-2.19,.77,;-3.53,,;-3.69,-1.53,;-5.19,-1.85,;-5.96,-.52,;-4.93,.63,;-.86,-1.54,;.47,-2.31,;.47,-3.85,)|	InChI=1S/C20H14BrClN4O2/c21-15-7-14-18(8-13(15)11-5-6-11)26(17-4-2-1-3-16(17)22)20(27)25-19(14)24-12-9-23-28-10-12/h1-4,7-11H,5-6H2,(H,24,25,27)	AYKBSUWZQDYYQC-UHFFFAOYSA-N	508272	US11130759, Cpd. No. 583::US11046691, Compound 583::6-bromo-1-(2-chlorophenyl)-7- cyclopropyl-4-(isoxazol-4-ylamino)- quinazolin-2(1H)-one::US11084798, Cpd No 583	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508272	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508272&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147035416	459093349							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072127	O[C@H]1CC[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |r,wU:1.0,wD:4.5,(-4.02,-2.44,;-4.79,-1.1,;-6.28,-.7,;-5.88,.78,;-4.39,.38,;-3.06,1.15,;-1.72,.38,;-1.72,-1.15,;-.39,-1.93,;-.39,-3.47,;.94,-1.15,;2.28,-1.93,;2.28,-3.47,;3.61,-4.23,;4.94,-3.47,;4.94,-1.93,;3.61,-1.15,;3.61,.38,;.94,.38,;2.28,1.15,;2.28,2.69,;3.61,3.47,;4.94,2.69,;6.28,3.47,;4.94,1.15,;4.94,4.23,;.94,3.47,;-.39,2.69,;-.39,1.15,)|	InChI=1S/C19H15ClF3N3O3/c20-12-3-1-2-4-14(12)26-15-9-10(29-19(21,22)23)5-6-11(15)17(25-18(26)28)24-13-7-8-16(13)27/h1-6,9,13,16,27H,7-8H2,(H,24,25,28)	ADYUNAJSBRNQGW-UHFFFAOYSA-N	508273	US11130759, Cpd. No. 584::US11046691, Compound 584::1-(2-chlorophenyl)-4-(((trans)-2- hydroxycyclobutyl)amino)-7- (trifluoromethoxy)-quinazolin-2(1H)- one::US11084798, Cpd No 584	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508273	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508273&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608244	459093350							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072128	Clc1ccccc1-n1c2cc(C3CC3)c(Br)cc2c(NCC2CC2)nc1=O |(4.69,,;4.69,-1.54,;6.03,-2.31,;6.03,-3.85,;4.69,-4.62,;3.36,-3.85,;3.36,-2.31,;2.03,-1.54,;2.03,,;3.36,.77,;3.36,2.31,;4.69,3.08,;6.18,3.48,;5.09,4.57,;2.03,3.08,;2.03,4.62,;.69,2.31,;.69,.77,;-.64,,;-1.97,.77,;-3.31,,;-4.64,.77,;-5.41,2.1,;-6.18,.77,;-.64,-1.54,;.69,-2.31,;.69,-3.85,)|	InChI=1S/C21H19BrClN3O/c22-16-9-15-19(10-14(16)13-7-8-13)26(18-4-2-1-3-17(18)23)21(27)25-20(15)24-11-12-5-6-12/h1-4,9-10,12-13H,5-8,11H2,(H,24,25,27)	IKYJNQSOAUBULZ-UHFFFAOYSA-N	508274	US11130759, Cpd. No. 585::US11046691, Compound 585::6-bromo-1-(2-chlorophenyl)-7- cyclopropyl-4-((cyclopropylmethyl)- amino)-quinazolin-2(1H)-one::US11084798, Cpd No 585	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508274	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508274&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150566545	459093351							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072129	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(Cl)cc12 |(-4.74,,;-3.41,.77,;-2.08,,;-2.08,-1.54,;-.74,-2.31,;-.74,-3.85,;.59,-1.54,;1.92,-2.31,;1.92,-3.85,;3.26,-4.62,;4.59,-3.85,;4.59,-2.31,;3.26,-1.54,;3.26,,;.59,,;1.92,.77,;1.92,2.31,;3.26,3.08,;4.74,3.48,;3.66,4.57,;.59,3.08,;.59,4.62,;-.74,2.31,;-.74,.77,)|	InChI=1S/C18H15Cl2N3O/c1-21-17-12-8-14(20)11(10-6-7-10)9-16(12)23(18(24)22-17)15-5-3-2-4-13(15)19/h2-5,8-10H,6-7H2,1H3,(H,21,22,24)	RDAAFYCRHYPOMC-UHFFFAOYSA-N	508275	US11130759, Cpd. No. 586::US11046691, Compound 586::6-chloro-1-(2-chlorophenyl)-7- cyclopropyl-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 586	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508275	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508275&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151693233	459093352							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072130	FC(F)(F)c1cc2n(-c3ccccc3Cl)c(=O)nc(NCC3CC3)c2cc1Cl |(6.1,2.31,;4.77,3.08,;4.77,4.62,;4.77,1.54,;3.44,2.31,;3.44,.77,;2.1,,;2.1,-1.54,;3.44,-2.31,;3.44,-3.85,;4.77,-4.62,;6.1,-3.85,;6.1,-2.31,;4.77,-1.54,;4.77,,;.77,-2.31,;.77,-3.85,;-.56,-1.54,;-.56,,;-1.9,.77,;-3.23,,;-4.56,.77,;-5.33,2.1,;-6.1,.77,;.77,.77,;.77,2.31,;2.1,3.08,;2.1,4.62,)|	InChI=1S/C19H14Cl2F3N3O/c20-13-3-1-2-4-15(13)27-16-8-12(19(22,23)24)14(21)7-11(16)17(26-18(27)28)25-9-10-5-6-10/h1-4,7-8,10H,5-6,9H2,(H,25,26,28)	DLYRXQVLTCXOJY-UHFFFAOYSA-N	508276	US11130759, Cpd. No. 587::US11046691, Compound 587::6-chloro-1-(2-chlorophenyl)-4- ((cyclopropylmethyl)amino)-7- (trifluoromethyl)-quinazolin-2(1H)-one::US11084798, Cpd No 587	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508276	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508276&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150054326	459093353							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072131	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(c(Cl)cc12)C(F)(F)F |(-4.67,,;-3.33,.77,;-2,,;-2,-1.54,;-.67,-2.31,;-.67,-3.85,;.67,-1.54,;2,-2.31,;2,-3.85,;3.33,-4.62,;4.67,-3.85,;4.67,-2.31,;3.33,-1.54,;3.33,,;.67,,;2,.77,;2,2.31,;.67,3.08,;.67,4.62,;-.67,2.31,;-.67,.77,;3.33,3.08,;4.67,2.31,;3.33,4.62,;4.67,3.85,)|	InChI=1S/C16H10Cl2F3N3O/c1-22-14-8-6-11(18)9(16(19,20)21)7-13(8)24(15(25)23-14)12-5-3-2-4-10(12)17/h2-7H,1H3,(H,22,23,25)	HVMZLZIPGPEMAP-UHFFFAOYSA-N	508277	US11130759, Cpd. No. 588::US11046691, Compound 588::6-chloro-1-(2-chlorophenyl)-4- (methylamino)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 588	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508277	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508277&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147854736	459093354							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072132	Clc1ccccc1-n1c2cc(Br)c(Cl)cc2c(NCC2CC2)nc1=O |(4.77,,;4.77,-1.54,;6.1,-2.31,;6.1,-3.85,;4.77,-4.62,;3.44,-3.85,;3.44,-2.31,;2.1,-1.54,;2.1,,;3.44,.77,;3.44,2.31,;4.77,3.08,;2.1,3.08,;2.1,4.62,;.77,2.31,;.77,.77,;-.56,,;-1.9,.77,;-3.23,,;-4.56,.77,;-5.33,2.1,;-6.1,.77,;-.56,-1.54,;.77,-2.31,;.77,-3.85,)|	InChI=1S/C18H14BrCl2N3O/c19-12-8-16-11(7-14(12)21)17(22-9-10-5-6-10)23-18(25)24(16)15-4-2-1-3-13(15)20/h1-4,7-8,10H,5-6,9H2,(H,22,23,25)	IWICBEAAVZXZBT-UHFFFAOYSA-N	508278	US11130759, Cpd. No. 589::US11046691, Compound 589::7-bromo-6-chloro-1-(2-chlorophenyl)-4- ((cyclopropylmethyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 589	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508278	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508278&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147997672	459093355							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072133	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(Br)c(Cl)cc12 |(-4.67,,;-3.33,.77,;-2,,;-2,-1.54,;-.67,-2.31,;-.67,-3.85,;.67,-1.54,;2,-2.31,;2,-3.85,;3.33,-4.62,;4.67,-3.85,;4.67,-2.31,;3.33,-1.54,;3.33,,;.67,,;2,.77,;2,2.31,;3.33,3.08,;.67,3.08,;.67,4.62,;-.67,2.31,;-.67,.77,)|	InChI=1S/C15H10BrCl2N3O/c1-19-14-8-6-11(18)9(16)7-13(8)21(15(22)20-14)12-5-3-2-4-10(12)17/h2-7H,1H3,(H,19,20,22)	KIONVPPGAVHWDH-UHFFFAOYSA-N	508279	US11130759, Cpd. No. 590::US11046691, Compound 590::7-bromo-6-chloro-1-(2-chlorophenyl)- 4-(methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 590	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508279	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508279&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148203478	459093356							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072134	CNc1nc(=O)n(-c2cccnc2C(F)(F)F)c2cc(ccc12)C1CC1 |(-4.77,.1,;-3.44,.87,;-2.1,.1,;-2.1,-1.44,;-.77,-2.21,;-.77,-3.75,;.56,-1.44,;1.9,-2.21,;1.9,-3.75,;3.23,-4.52,;4.56,-3.75,;4.56,-2.21,;3.23,-1.38,;3.23,.16,;3.23,1.7,;1.69,.16,;4.77,.16,;.56,.1,;1.9,.87,;1.9,2.41,;.56,3.18,;-.77,2.41,;-.77,.87,;3.23,3.18,;4.77,3.18,;4,4.52,)|	InChI=1S/C18H15F3N4O/c1-22-16-12-7-6-11(10-4-5-10)9-14(12)25(17(26)24-16)13-3-2-8-23-15(13)18(19,20)21/h2-3,6-10H,4-5H2,1H3,(H,22,24,26)	BBRWWACDHUELCW-UHFFFAOYSA-N	508280	US11130759, Cpd. No. 591::US11046691, Compound 591::7-cyclopropyl-4-(methylamino)-1-(2- (trifluoromethyl)pyridin-3- yl)quinazolin-2(1H)-one::US11084798, Cpd No 591	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508280	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508280&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147053076	459093357							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072135	CNc1nc(=O)n(-c2cccnc2OC(F)F)c2cc(ccc12)C1CC1 |(-5.33,.1,;-4,.87,;-2.67,.1,;-2.67,-1.44,;-1.33,-2.21,;-1.33,-3.75,;,-1.44,;1.33,-2.21,;1.33,-3.75,;2.67,-4.52,;4,-3.75,;4,-2.21,;2.67,-1.44,;2.67,.1,;4,.87,;4,2.41,;5.33,.1,;,.1,;1.33,.87,;1.33,2.41,;,3.18,;-1.33,2.41,;-1.33,.87,;2.67,3.18,;4.21,3.18,;3.44,4.52,)|	InChI=1S/C18H16F2N4O2/c1-21-15-12-7-6-11(10-4-5-10)9-14(12)24(18(25)23-15)13-3-2-8-22-16(13)26-17(19)20/h2-3,6-10,17H,4-5H2,1H3,(H,21,23,25)	XPVXLPOHZZRXNQ-UHFFFAOYSA-N	508281	US11130759, Cpd. No. 592::US11046691, Compound 592::7-cyclopropyl-1-(2-(difluoro- methoxy)pyridin-3-yl)-4- (methylamino)-quinazolin-2(1H)-one::US11084798, Cpd No 592	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508281	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508281&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149264385	459093358							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072136	FC(F)(F)Oc1ccc2c(NCC3CC3)nc(=O)n(-c3cccc4nccn34)c2c1 |(6.77,4.3,;5.44,3.53,;5.44,1.99,;5.44,5.07,;4.1,4.3,;2.77,3.53,;1.44,4.3,;.1,3.53,;.1,1.99,;-1.23,1.22,;-2.56,1.99,;-3.9,1.22,;-5.23,1.99,;-6,3.32,;-6.77,1.99,;-1.23,-.32,;.1,-1.09,;.1,-2.63,;1.44,-.32,;2.77,-1.09,;4.1,-.32,;5.44,-1.09,;5.44,-2.63,;4.1,-3.4,;3.78,-4.91,;2.25,-5.07,;1.63,-3.66,;2.77,-2.63,;1.44,1.22,;2.77,1.99,)|	InChI=1S/C20H16F3N5O2/c21-20(22,23)30-13-6-7-14-15(10-13)28(17-3-1-2-16-24-8-9-27(16)17)19(29)26-18(14)25-11-12-4-5-12/h1-3,6-10,12H,4-5,11H2,(H,25,26,29)	UQINCFOMYBSDHF-UHFFFAOYSA-N	508282	US11130759, Cpd. No. 593::US11046691, Compound 593::4-((cyclopropylmethyl)amino)-1- (imadazo[1,2-a]pyridin-5-yl)-7- (trifluoromethoxy)-quinazolin-2(1H)- one::US11084798, Cpd No 593	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508282	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508282&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152959824	459093359							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072137	CNc1nc(=O)n(-c2cccc3nccn23)c2cc(OC(F)(F)F)ccc12 |(-5.33,1.22,;-4,1.99,;-2.67,1.22,;-2.67,-.32,;-1.33,-1.09,;-1.33,-2.63,;,-.32,;1.33,-1.09,;2.67,-.32,;4,-1.09,;4,-2.63,;2.67,-3.4,;2.35,-4.91,;.82,-5.07,;.19,-3.66,;1.33,-2.63,;,1.22,;1.33,1.99,;1.33,3.53,;2.67,4.3,;4,3.53,;5.33,4.3,;4,1.99,;4,5.07,;,4.3,;-1.33,3.53,;-1.33,1.99,)|	InChI=1S/C17H12F3N5O2/c1-21-15-11-6-5-10(27-17(18,19)20)9-12(11)25(16(26)23-15)14-4-2-3-13-22-7-8-24(13)14/h2-9H,1H3,(H,21,23,26)	OJHAZXPYPQMYSE-UHFFFAOYSA-N	508283	US11130759, Cpd. No. 594::US11046691, Compound 594::1-(imidazo[1,2-a]pyridin-5-yl)-4- (methylamino)-7-(trifluoromethoxy)- quinazolin-2(1H)-one::US11084798, Cpd No 594	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508283	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508283&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148775589	459093360							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072138	FC(F)(F)Oc1ccc2c(Nc3cnoc3)nc(=O)n(-c3ccccc3Cl)c2c1 |(6.55,3.47,;5.22,2.69,;5.22,1.15,;5.22,4.23,;3.89,3.47,;2.55,2.69,;1.22,3.47,;-.11,2.69,;-.11,1.15,;-1.45,.38,;-2.78,1.15,;-4.12,.38,;-4.28,-1.15,;-5.78,-1.47,;-6.55,-.13,;-5.52,1.01,;-1.45,-1.15,;-.11,-1.93,;-.11,-3.47,;1.22,-1.15,;2.55,-1.93,;2.55,-3.47,;3.89,-4.23,;5.22,-3.47,;5.22,-1.93,;3.89,-1.16,;3.89,.38,;1.22,.38,;2.55,1.15,)|	InChI=1S/C18H10ClF3N4O3/c19-13-3-1-2-4-14(13)26-15-7-11(29-18(20,21)22)5-6-12(15)16(25-17(26)27)24-10-8-23-28-9-10/h1-9H,(H,24,25,27)	HQJQCKRVZOBRRX-UHFFFAOYSA-N	508284	US11130759, Cpd. No. 595::US11046691, Compound 595::1-(2-chlorophenyl)-4-(isoxazol-4- ylamino)-7-(trifluoromethoxy)- quinazolin-2(1H)-one::US11084798, Cpd No 595	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508284	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508284&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608317	459093361							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072139	Cc1ccccc1-n1c2cc(ccc2c(Nc2cnsc2)nc1=O)C1CC1 |(4.45,.1,;4.45,-1.44,;5.78,-2.21,;5.78,-3.75,;4.45,-4.52,;3.12,-3.75,;3.12,-2.21,;1.78,-1.44,;1.78,.1,;3.12,.87,;3.12,2.41,;1.78,3.18,;.45,2.41,;.45,.87,;-.88,.1,;-2.22,.87,;-3.55,.1,;-3.71,-1.43,;-5.22,-1.75,;-5.99,-.41,;-4.96,.73,;-.88,-1.44,;.45,-2.21,;.45,-3.75,;4.45,3.18,;5.99,3.18,;5.22,4.52,)|	InChI=1S/C21H18N4OS/c1-13-4-2-3-5-18(13)25-19-10-15(14-6-7-14)8-9-17(19)20(24-21(25)26)23-16-11-22-27-12-16/h2-5,8-12,14H,6-7H2,1H3,(H,23,24,26)	UBNILIKUIDHZOI-UHFFFAOYSA-N	508285	US11130759, Cpd. No. 596::US11046691, Compound 596::7-cyclopropyl-4-(isothiazol-4-ylamino)- 1-(o-tolyl)quinazolin-2(1H)-one::US11084798, Cpd No 596	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508285	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508285&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151975239	459093362							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072140	Cc1ccccc1-n1c2cc(ccc2c(Nc2cnoc2)nc1=O)C1CC1 |(4.45,.1,;4.45,-1.44,;5.78,-2.21,;5.78,-3.75,;4.45,-4.52,;3.12,-3.75,;3.12,-2.21,;1.78,-1.44,;1.78,.1,;3.12,.87,;3.12,2.41,;1.78,3.18,;.45,2.41,;.45,.87,;-.88,.1,;-2.22,.87,;-3.55,.1,;-3.71,-1.43,;-5.22,-1.75,;-5.99,-.41,;-4.96,.73,;-.88,-1.44,;.45,-2.21,;.45,-3.75,;4.45,3.18,;5.99,3.18,;5.22,4.52,)|	InChI=1S/C21H18N4O2/c1-13-4-2-3-5-18(13)25-19-10-15(14-6-7-14)8-9-17(19)20(24-21(25)26)23-16-11-22-27-12-16/h2-5,8-12,14H,6-7H2,1H3,(H,23,24,26)	HFNJSKMWCDCNSW-UHFFFAOYSA-N	508286	US11130759, Cpd. No. 597::US11046691, Compound 597::7-cyclopropyl-4-(isoxazol-4-ylamino)- 1-(o-tolyl)quinazolin-2(1H)-one::US11084798, Cpd No 597	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508286	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508286&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147768801	459093363							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072141	F[C@@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |r,wD:3.4,1.0,(-5.33,-2.46,;-5.33,-.92,;-6.1,.41,;-4.56,.41,;-3.23,1.18,;-1.9,.41,;-1.9,-1.13,;-.56,-1.9,;-.56,-3.44,;.77,-1.13,;2.1,-1.9,;2.1,-3.44,;3.44,-4.21,;4.77,-3.44,;4.77,-1.9,;3.44,-1.13,;3.44,.41,;.77,.41,;2.1,1.18,;2.1,2.72,;3.44,3.49,;4.77,2.72,;6.1,3.49,;4.77,1.18,;4.37,4.21,;.77,3.49,;-.56,2.72,;-.56,1.18,)|	InChI=1S/C18H12ClF4N3O2/c19-11-3-1-2-4-14(11)26-15-7-9(28-18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	CPLJBLXSCDZION-UHFFFAOYSA-N	508287	US11130759, Cpd. No. 598::US11046691, Compound 598::1-(2-chlorophenyl)-4-(((1S,2R)-2- fluorocyclopropyl)amino)-7- (trifluoromethoxy)-quinazolin-2(1H)- one::US11084798, Cpd No 598	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508287	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508287&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933628	459093364							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072142	F[C@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |r,wU:3.4,1.0,(-5.33,-2.46,;-5.33,-.92,;-6.1,.41,;-4.56,.41,;-3.23,1.18,;-1.9,.41,;-1.9,-1.13,;-.56,-1.9,;-.56,-3.44,;.77,-1.13,;2.1,-1.9,;2.1,-3.44,;3.44,-4.21,;4.77,-3.44,;4.77,-1.9,;3.44,-1.13,;3.44,.41,;.77,.41,;2.1,1.18,;2.1,2.72,;3.44,3.49,;4.77,2.72,;6.1,3.49,;4.77,1.18,;4.37,4.21,;.77,3.49,;-.56,2.72,;-.56,1.18,)|	InChI=1S/C18H12ClF4N3O2/c19-11-3-1-2-4-14(11)26-15-7-9(28-18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	CPLJBLXSCDZION-UHFFFAOYSA-N	508288	US11130759, Cpd. No. 599::US11046691, Compound 599::1-(2-chlorophenyl)-4-(((1R,2S)-2- fluorocyclopropyl)amino)-7- (trifluoromethoxy)-quinazolin-2(1H)- one::US11084798, Cpd No 599	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508288	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508288&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608306	459093365							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072143	CNc1nc(=O)n(-c2cccnn2)c2cc(ccc12)C(F)(F)F	InChI=1S/C14H10F3N5O/c1-18-12-9-5-4-8(14(15,16)17)7-10(9)22(13(23)20-12)11-3-2-6-19-21-11/h2-7H,1H3,(H,18,20,23)	CDACLKDANRYAIL-UHFFFAOYSA-N	508290	US11130759, Cpd. No. 601::US11046691, Compound 601::4-(methylamino)-1-(pyridazin-3-yl)-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 600	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508290	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508290&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149880166	459093367							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072144	FC(F)(F)c1ccc2c(Nc3cnsc3)nc(=O)n(-c3ccccc3Cl)c2n1 |(5.89,2.31,;4.55,3.08,;4.55,4.62,;4.55,1.54,;3.22,2.31,;1.89,3.08,;.55,2.31,;.55,.77,;-.78,,;-2.12,.77,;-3.45,,;-3.61,-1.53,;-5.12,-1.85,;-5.89,-.52,;-4.86,.63,;-.78,-1.54,;.55,-2.31,;.55,-3.85,;1.89,-1.54,;3.22,-2.31,;3.22,-3.85,;4.55,-4.62,;5.89,-3.85,;5.89,-2.31,;4.55,-1.54,;4.55,,;1.89,,;3.22,.77,)|	InChI=1S/C17H9ClF3N5OS/c18-11-3-1-2-4-12(11)26-15-10(5-6-13(24-15)17(19,20)21)14(25-16(26)27)23-9-7-22-28-8-9/h1-8H,(H,23,25,27)	XTIABRMENOKOKA-UHFFFAOYSA-N	508289	US11130759, Cpd. No. 600::US11046691, Compound 600::1-(2-chlorophenyl)-4-(isothiazol-4- ylamino)-7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 601	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508289	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508289&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149283015	459093366							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072145	CC(F)(F)c1ccc2c(NCC3CC3)nc(=O)n(-c3cccc4nccn34)c2c1 |(6.1,3.25,;4.77,4.02,;4,5.35,;5.54,5.35,;3.44,3.25,;2.1,4.02,;.77,3.25,;.77,1.71,;-.56,.94,;-1.9,1.71,;-3.23,.94,;-4.56,1.71,;-5.33,3.04,;-6.1,1.71,;-.56,-.6,;.77,-1.37,;.77,-2.91,;2.1,-.6,;3.44,-1.37,;4.77,-.6,;6.1,-1.37,;6.1,-2.91,;4.77,-3.68,;4.45,-5.19,;2.92,-5.35,;2.29,-3.94,;3.44,-2.91,;2.1,.94,;3.44,1.71,)|	InChI=1S/C21H19F2N5O/c1-21(22,23)14-7-8-15-16(11-14)28(18-4-2-3-17-24-9-10-27(17)18)20(29)26-19(15)25-12-13-5-6-13/h2-4,7-11,13H,5-6,12H2,1H3,(H,25,26,29)	QCZVJZRKVKPRIX-UHFFFAOYSA-N	508291	US11130759, Cpd. No. 602::US11046691, Compound 602::4-((cyclopropylmethyl)amino)-7-(1,1- difluoroethyl)-1-(imidazo[1,2-a]pyridin- 5-yl)quinazolin-2(1H)-one::US11084798, Cpd No 602	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508291	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508291&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608847	459093368							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072146	O=c1nc(NCC2CC2)c2ccc(cc2n1-c1cccc2nccn12)C1CC1 |(.67,-2.91,;.67,-1.37,;-.67,-.6,;-.67,.94,;-2,1.71,;-3.33,.94,;-4.67,1.71,;-5.44,3.04,;-6.21,1.71,;.67,1.71,;.67,3.25,;2,4.02,;3.33,3.25,;3.33,1.71,;2,.94,;2,-.6,;3.33,-1.37,;4.67,-.6,;6,-1.37,;6,-2.91,;4.67,-3.68,;4.35,-5.19,;2.82,-5.35,;2.19,-3.94,;3.33,-2.91,;4.67,4.02,;6.21,4.02,;5.44,5.35,)|	InChI=1S/C22H21N5O/c28-22-25-21(24-13-14-4-5-14)17-9-8-16(15-6-7-15)12-18(17)27(22)20-3-1-2-19-23-10-11-26(19)20/h1-3,8-12,14-15H,4-7,13H2,(H,24,25,28)	GLHQHGSFOMHRJE-UHFFFAOYSA-N	508292	US11130759, Cpd. No. 603::US11046691, Compound 603::7-cyclopropyl-4-((cyclopropylmethyl)- amino)-1-(imidazo[1,2-a]pyridin-5-yl)- quinazolin-2(1H)-one::US11084798, Cpd No 603	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508292	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508292&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608842	459093369							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072147	CNc1nc(=O)n(-c2cnccn2)c2cc(ccc12)C(F)(F)F	InChI=1S/C14H10F3N5O/c1-18-12-9-3-2-8(14(15,16)17)6-10(9)22(13(23)21-12)11-7-19-4-5-20-11/h2-7H,1H3,(H,18,21,23)	ZCIFQBXBKAOIMN-UHFFFAOYSA-N	508293	US11130759, Cpd. No. 604::US11046691, Compound 604::4-(methylamino)-1-(pyrazin-2-yl)-7- (trifluoromethyl)quinazolin-2(1H)-one::US11084798, Cpd No 604	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508293	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508293&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152625036	459093370							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072148	CC(F)(F)c1ccc2c(NC3CC3)nc(=O)n(-c3cccc4nccn34)c2c1 |(5.44,3.25,;4.1,4.02,;3.33,5.35,;4.87,5.35,;2.77,3.25,;1.44,4.02,;.1,3.25,;.1,1.71,;-1.23,.94,;-2.56,1.71,;-3.9,.94,;-5.44,.94,;-4.67,-.4,;-1.23,-.6,;.1,-1.37,;.1,-2.91,;1.44,-.6,;2.77,-1.37,;4.1,-.6,;5.44,-1.37,;5.44,-2.91,;4.1,-3.68,;3.78,-5.19,;2.25,-5.35,;1.63,-3.94,;2.77,-2.91,;1.44,.94,;2.77,1.71,)|	InChI=1S/C20H17F2N5O/c1-20(21,22)12-5-8-14-15(11-12)27(19(28)25-18(14)24-13-6-7-13)17-4-2-3-16-23-9-10-26(16)17/h2-5,8-11,13H,6-7H2,1H3,(H,24,25,28)	KFISULFSKFSYSW-UHFFFAOYSA-N	508294	US11130759, Cpd. No. 605::US11046691, Compound 605::4-(cyclopropylamino)-7-(1,1- difluoroethyl)-1-(imidazo[1,2-a]pyridin- 5-yl)-quinazolin-2(1H)-one::US11084798, Cpd No 605	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508294	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508294&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608515	459093371							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072149	COCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-7.28,1.09,;-6.1,.1,;-4.77,.87,;-3.44,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;3.23,-3.75,;4.56,-4.52,;5.9,-3.75,;5.9,-2.21,;4.56,-1.44,;4.56,.1,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,)|	InChI=1S/C20H20ClN3O2/c1-26-11-10-22-19-15-9-8-14(13-6-7-13)12-18(15)24(20(25)23-19)17-5-3-2-4-16(17)21/h2-5,8-9,12-13H,6-7,10-11H2,1H3,(H,22,23,25)	SAIKNVSKLNKRDM-UHFFFAOYSA-N	508263	US11130759, Cpd. No. 606::US11046691, Compound 574::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-methoxyethyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 606	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508263&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608626	459093340							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072150	OCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-6.1,.1,;-4.77,.87,;-3.44,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;3.23,-3.75,;4.56,-4.52,;5.9,-3.75,;5.9,-2.21,;4.56,-1.44,;4.56,.1,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,)|	InChI=1S/C19H18ClN3O2/c20-15-3-1-2-4-16(15)23-17-11-13(12-5-6-12)7-8-14(17)18(21-9-10-24)22-19(23)25/h1-4,7-8,11-12,24H,5-6,9-10H2,(H,21,22,25)	UVRCNALCQMXMDW-UHFFFAOYSA-N	508264	US11130759, Cpd. No. 607::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-hydroxyethyl)amino)quinazolin- 2(1H)-one::US11046691, Compound 607::US11046691, Compound 575::US11084798, Cpd No 607	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508264&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608389	459093341							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072151	Clc1ccccc1-n1c2cc(ccc2c(NCC2CC2)nc1=O)C1CC1 |(4.68,.04,;4.68,-1.5,;6.02,-2.27,;6.02,-3.81,;4.68,-4.58,;3.35,-3.81,;3.35,-2.27,;2.02,-1.5,;2.02,.04,;3.35,.81,;3.35,2.35,;2.02,3.12,;.68,2.35,;.68,.81,;-.65,.04,;-1.98,.81,;-3.32,.04,;-4.65,.81,;-5.42,2.14,;-6.19,.81,;-.65,-1.5,;.68,-2.27,;.68,-3.81,;4.68,3.12,;5.16,4.58,;6.19,3.44,)|	InChI=1S/C21H20ClN3O/c22-17-3-1-2-4-18(17)25-19-11-15(14-7-8-14)9-10-16(19)20(24-21(25)26)23-12-13-5-6-13/h1-4,9-11,13-14H,5-8,12H2,(H,23,24,26)	QTBWLICWTDOOAS-UHFFFAOYSA-N	508297	US11130759, Cpd. No. 608::US11046691, Compound 608::1-(2-chlorophenyl)-7-cyclopropyl-4- ((cyclopropylmethyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 608	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508297&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608721	459093373							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072152	Clc1ccccc1-n1c2cc(ccc2c(NC2CC2)nc1=O)C1CC1 |(4,.1,;4,-1.44,;5.33,-2.21,;5.33,-3.75,;4,-4.52,;2.67,-3.75,;2.67,-2.21,;1.33,-1.44,;1.33,.1,;2.67,.87,;2.67,2.41,;1.33,3.18,;,2.41,;,.87,;-1.33,.1,;-2.67,.87,;-4,.1,;-5.54,.1,;-4.77,-1.23,;-1.33,-1.44,;,-2.21,;,-3.75,;4,3.18,;5.54,3.18,;4.77,4.52,)|	InChI=1S/C20H18ClN3O/c21-16-3-1-2-4-17(16)24-18-11-13(12-5-6-12)7-10-15(18)19(23-20(24)25)22-14-8-9-14/h1-4,7,10-12,14H,5-6,8-9H2,(H,22,23,25)	OHCXBOMYPCPYMP-UHFFFAOYSA-N	508298	US11130759, Cpd. No. 609::US11046691, Compound 609::1-(2-chlorophenyl)-7-cyclopropyl-4- (cyclopropylamino)quinazolin-2(1H)- one::US11084798, Cpd No 609	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508298	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508298&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609045	459093374							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072153	CNc1nc(=O)n(-c2cccc3nccn23)c2cc(ccc12)C(C)(F)F |(1.56,5.65,;.23,4.88,;.23,3.34,;-1.1,2.57,;-1.1,1.03,;-2.44,.26,;.23,.26,;.23,-1.28,;1.56,-2.05,;1.56,-3.59,;.23,-4.36,;-1.1,-3.59,;-2.57,-4.07,;-3.47,-2.82,;-2.57,-1.58,;-1.1,-2.05,;1.56,1.03,;2.9,.26,;4.23,1.03,;4.23,2.57,;2.9,3.34,;1.56,2.57,;5.56,.26,;4.79,-1.08,;6.9,-.51,;6.33,1.59,)|	InChI=1S/C18H15F2N5O/c1-18(19,20)11-6-7-12-13(10-11)25(17(26)23-16(12)21-2)15-5-3-4-14-22-8-9-24(14)15/h3-10H,1-2H3,(H,21,23,26)	LFASOGJQPWSVCM-UHFFFAOYSA-N	508299	US11130759, Cpd. No. 610::US11046691, Compound 610::7-(1,1-difluoroethyl)-1-(imidazo[1,2- a]pyridin-5-yl)-4-(methylamino)- quinazolin-2(1H)-one::US11084798, Cpd No 610	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508299	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508299&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608831	459093375							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072154	OCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |(-6.67,.38,;-5.33,1.15,;-4,.38,;-2.67,1.15,;-1.33,.38,;-1.33,-1.16,;,-1.93,;,-3.47,;1.33,-1.16,;2.67,-1.93,;2.67,-3.47,;4,-4.23,;5.33,-3.47,;5.33,-1.92,;4,-1.15,;4,.38,;1.33,.38,;2.67,1.15,;2.67,2.69,;4,3.46,;5.33,2.69,;6.67,3.47,;5.33,1.15,;5.33,4.23,;1.33,3.46,;,2.69,;,1.15,)|	InChI=1S/C17H13ClF3N3O3/c18-12-3-1-2-4-13(12)24-14-9-10(27-17(19,20)21)5-6-11(14)15(22-7-8-25)23-16(24)26/h1-6,9,25H,7-8H2,(H,22,23,26)	MBKJGOAZYZSPEM-UHFFFAOYSA-N	508300	US11130759, Cpd. No. 611::US11046691, Compound 611::1-(2-chlorophenyl)-4((2- hydroxyethyl)-amino)-7- (trifluoromethoxy)quinazolin-2(1H)- one::US11084798, Cpd No 611	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508300	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508300&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608550	459093376							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072155	CC(F)(F)c1ccc2c(N[C@H]3C[C@H](O)C3)nc(=O)n(-c3ccccc3Cl)c2c1 |r,wU:12.12,wD:10.9,(4.65,4.62,;4.65,3.08,;5.98,2.31,;4.65,1.54,;3.32,2.31,;1.98,3.08,;.65,2.31,;.65,.77,;-.69,,;-2.02,.77,;-3.35,,;-4.89,,;-4.89,-1.54,;-5.98,-2.63,;-3.35,-1.54,;-.69,-1.54,;.65,-2.31,;.65,-3.85,;1.98,-1.54,;3.32,-2.31,;3.32,-3.85,;4.65,-4.62,;5.98,-3.85,;5.98,-2.31,;4.65,-1.54,;4.65,,;1.98,,;3.32,.77,)|	InChI=1S/C20H18ClF2N3O2/c1-20(22,23)11-6-7-14-17(8-11)26(16-5-3-2-4-15(16)21)19(28)25-18(14)24-12-9-13(27)10-12/h2-8,12-13,27H,9-10H2,1H3,(H,24,25,28)	NYPAXFBNIDICQX-UHFFFAOYSA-N	508301	US11130759, Cpd. No. 612::US11046691, Compound 612::1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4-(((trans)-3- hydroxycyclobutyl)amino)-quinazolin- 2(1H)-one::US11084798, Cpd No 612	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508301&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608286	459093377							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072156	COCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(C)(F)F |(-6.67,.77,;-5.33,,;-4,.77,;-2.67,,;-1.33,.77,;;,-1.54,;1.33,-2.31,;1.33,-3.85,;2.67,-1.54,;4,-2.31,;4,-3.85,;5.33,-4.62,;6.67,-3.85,;6.67,-2.31,;5.33,-1.54,;5.33,,;2.67,,;4,.77,;4,2.31,;2.67,3.08,;1.33,2.31,;1.33,.77,;5.33,3.08,;5.33,4.62,;6.67,2.31,;5.33,1.54,)|	InChI=1S/C19H18ClF2N3O2/c1-19(21,22)12-7-8-13-16(11-12)25(15-6-4-3-5-14(15)20)18(26)24-17(13)23-9-10-27-2/h3-8,11H,9-10H2,1-2H3,(H,23,24,26)	DIJDIRSAYVQSFM-UHFFFAOYSA-N	508302	US11130759, Cpd. No. 613::US11046691, Compound 613::1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4-((2- methoxyethyl)amino)quinazolin-2(1H)- one::US11084798, Cpd No 613	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508302	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508302&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608446	459093378							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072157	CC(F)(F)c1ccc2c(NCCO)nc(=O)n(-c3ccccc3Cl)c2c1 |(4.67,4.62,;4.67,3.08,;6,2.31,;4.67,1.54,;3.33,2.31,;2,3.08,;.67,2.31,;.67,.77,;-.67,,;-2,.77,;-3.33,,;-4.67,.77,;-6,,;-.67,-1.54,;.67,-2.31,;.67,-3.85,;2,-1.54,;3.33,-2.31,;3.33,-3.85,;4.67,-4.62,;6,-3.85,;6,-2.31,;4.67,-1.54,;4.67,,;2,,;3.33,.77,)|	InChI=1S/C18H16ClF2N3O2/c1-18(20,21)11-6-7-12-15(10-11)24(14-5-3-2-4-13(14)19)17(26)23-16(12)22-8-9-25/h2-7,10,25H,8-9H2,1H3,(H,22,23,26)	WEWRUDVPTNTYMW-UHFFFAOYSA-N	508303	US11130759, Cpd. No. 614::US11046691, Compound 614::1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4-((2- hydroxyethyl)amino)quinazolin-2(1H)- one::US11084798, Cpd No 614	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508303	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508303&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608832	459093379							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072158	CC(F)(F)c1ccc2c(NC3CC3)nc(=O)n(-c3ccccc3Cl)c2c1 |(4.1,4.62,;4.1,3.08,;5.44,2.31,;4.1,1.54,;2.77,2.31,;1.44,3.08,;.1,2.31,;.1,.77,;-1.23,,;-2.56,.77,;-3.9,,;-5.44,,;-4.67,-1.33,;-1.23,-1.54,;.1,-2.31,;.1,-3.85,;1.44,-1.54,;2.77,-2.31,;2.77,-3.85,;4.1,-4.62,;5.44,-3.85,;5.44,-2.31,;4.1,-1.54,;4.1,,;1.44,,;2.77,.77,)|	InChI=1S/C19H16ClF2N3O/c1-19(21,22)11-6-9-13-16(10-11)25(15-5-3-2-4-14(15)20)18(26)24-17(13)23-12-7-8-12/h2-6,9-10,12H,7-8H2,1H3,(H,23,24,26)	AFBCUKKDKCDUOL-UHFFFAOYSA-N	508304	US11130759, Cpd. No. 615::US11046691, Compound 615::1-(2-chlorophenyl)-4-(cyclopropyl- amino)-7-(1,1-difluoroethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 615	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508304	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508304&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608753	459093380							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072159	O[C@H]1C[C@@H](C1)Nc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |r,wU:1.0,wD:3.5,(-6.65,-2.24,;-5.56,-1.15,;-5.56,.38,;-4.02,.38,;-4.02,-1.15,;-2.69,1.15,;-1.35,.38,;-1.35,-1.15,;-.02,-1.93,;-.02,-3.47,;1.31,-1.15,;2.65,-1.93,;2.65,-3.47,;3.98,-4.23,;5.32,-3.47,;5.32,-1.93,;3.98,-1.15,;3.98,.38,;1.31,.38,;2.65,1.15,;2.65,2.69,;3.98,3.47,;5.32,2.69,;6.65,3.47,;5.32,4.23,;5.32,1.15,;1.31,3.47,;-.02,2.69,;-.02,1.15,)|	InChI=1S/C19H15ClF3N3O3/c20-14-3-1-2-4-15(14)26-16-9-12(29-19(21,22)23)5-6-13(16)17(25-18(26)28)24-10-7-11(27)8-10/h1-6,9-11,27H,7-8H2,(H,24,25,28)	FKJMMRJKJWKGKY-UHFFFAOYSA-N	508305	US11130759, Cpd. No. 616::US11046691, Compound 616::1-(2-chlorophenyl)-4-(((trans)-3- hydroxycyclobutyl)amino)-7- (trifluoromethoxy)-quinazolin-2(1H)- one::US11084798, Cpd No 616	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508305	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508305&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147516768	459093381							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072160	COCCNc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |(-7.34,1.15,;-6,.38,;-4.67,1.15,;-3.33,.38,;-2,1.15,;-.67,.38,;-.67,-1.15,;.67,-1.93,;.67,-3.47,;2,-1.15,;3.33,-1.93,;3.33,-3.47,;4.67,-4.23,;6,-3.47,;6,-1.93,;4.67,-1.15,;4.67,.38,;2,.38,;3.33,1.15,;3.33,2.69,;4.67,3.47,;6,2.69,;7.34,3.47,;6,4.23,;6,1.15,;2,3.47,;.67,2.69,;.67,1.15,)|	InChI=1S/C18H15ClF3N3O3/c1-27-9-8-23-16-12-7-6-11(28-18(20,21)22)10-15(12)25(17(26)24-16)14-5-3-2-4-13(14)19/h2-7,10H,8-9H2,1H3,(H,23,24,26)	HRLFIXDJFMETLM-UHFFFAOYSA-N	508306	US11130759, Cpd. No. 617::US11046691, Compound 617::1-(2-chlorophenyl)-4((2- methoxyethyl)-amino)-7- (trifluoromethoxy)quinazolin-2(1H)- one::US11084798, Cpd No 617	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508306	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508306&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608908	459093382							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072161	FC(F)(F)Oc1ccc2c(NCC3CC3)nc(=O)n(-c3ccccc3Cl)c2c1 |(6.77,3.47,;5.44,2.69,;5.44,4.23,;5.44,1.15,;4.1,3.47,;2.77,2.69,;1.44,3.47,;.1,2.69,;.1,1.15,;-1.23,.38,;-2.56,1.15,;-3.9,.38,;-5.23,1.15,;-6,2.49,;-6.77,1.15,;-1.23,-1.15,;.1,-1.93,;.1,-3.47,;1.44,-1.15,;2.77,-1.93,;2.77,-3.47,;4.1,-4.23,;5.44,-3.47,;5.44,-1.93,;4.1,-1.15,;4.1,.38,;1.44,.38,;2.77,1.15,)|	InChI=1S/C19H15ClF3N3O2/c20-14-3-1-2-4-15(14)26-16-9-12(28-19(21,22)23)7-8-13(16)17(25-18(26)27)24-10-11-5-6-11/h1-4,7-9,11H,5-6,10H2,(H,24,25,27)	NZRKXIHCKJTDFZ-UHFFFAOYSA-N	508307	US11130759, Cpd. No. 618::US11046691, Compound 618::1-(2-chlorophenyl)-4-((cyclopropyl- methyl)amino)-7-(trifluoromethoxy)- quinazolin-2(1H)-one::US11084798, Cpd No 618	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508307	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508307&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148724212	459093383							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072162	FC(F)(F)Oc1ccc2c(NC3CC3)nc(=O)n(-c3ccccc3Cl)c2c1 |(6.1,3.47,;4.77,2.69,;4.77,4.23,;4.77,1.15,;3.44,3.47,;2.1,2.69,;.77,3.47,;-.56,2.69,;-.56,1.15,;-1.9,.38,;-3.23,1.15,;-4.56,.38,;-6.1,.38,;-5.33,-.95,;-1.9,-1.15,;-.56,-1.93,;-.56,-3.47,;.77,-1.15,;2.1,-1.93,;2.1,-3.47,;3.44,-4.23,;4.77,-3.47,;4.77,-1.93,;3.44,-1.15,;3.44,.38,;.77,.38,;2.1,1.15,)|	InChI=1S/C18H13ClF3N3O2/c19-13-3-1-2-4-14(13)25-15-9-11(27-18(20,21)22)7-8-12(15)16(24-17(25)26)23-10-5-6-10/h1-4,7-10H,5-6H2,(H,23,24,26)	SDXQCBPWQHRMPX-UHFFFAOYSA-N	508308	US11130759, Cpd. No. 619::US11046691, Compound 619::1-(2-chlorophenyl)-4-(cyclopropyl- amino)-7-(trifluoromethoxy)quinazolin- 2(1H)-one::US11084798, Cpd No 619	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508308&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608778	459093384							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072163	FC(F)(F)c1ccc2c(Nc3ccnc(c3)C(F)(F)F)nc(=O)n(-c3ccccc3Cl)c2n1 |(6,2.69,;4.67,3.47,;4.67,5,;4.67,1.93,;3.33,2.69,;2,3.47,;.67,2.69,;.67,1.15,;-.67,.38,;-2,1.15,;-3.33,.38,;-4.67,1.15,;-6,.38,;-6,-1.15,;-4.67,-1.93,;-3.33,-1.15,;-4.67,-3.47,;-3.33,-4.23,;-6,-4.23,;-4.67,-5,;-.67,-1.15,;.67,-1.93,;.67,-3.47,;2,-1.15,;3.33,-1.93,;3.33,-3.47,;4.67,-4.23,;6,-3.47,;6,-1.93,;4.67,-1.15,;4.67,.38,;2,.38,;3.33,1.15,)|	InChI=1S/C20H10ClF6N5O/c21-12-3-1-2-4-13(12)32-17-11(5-6-14(30-17)19(22,23)24)16(31-18(32)33)29-10-7-8-28-15(9-10)20(25,26)27/h1-9H,(H,28,29,31,33)	WDJHJGXBIXCPRA-UHFFFAOYSA-N	508309	US11130759, Cpd. No. 620::US11046691, Compound 620::1-(2-chlorophenyl)-7-(trifluoromethyl)- 4((2-(trifluoromethyl)pyridin-4-yl)- amino)-pyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 620	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508309&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608762	459093385							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072164	CCc1ccc2c(NC)nc(=O)n(-c3cccnc3)c2n1	InChI=1S/C15H15N5O/c1-3-10-6-7-12-13(16-2)19-15(21)20(14(12)18-10)11-5-4-8-17-9-11/h4-9H,3H2,1-2H3,(H,16,19,21)	MCRBBRFETPGXEL-UHFFFAOYSA-N	508310	US11130759, Cpd. No. 621::US11046691, Compound 621::7-ethyl-4-(methylamino)-1-(pyridin-3- yl)pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 621	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508310&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151043928	459093386							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072165	COc1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3nc(ccc23)C(F)(F)F)ccn1 |(-6,-4.62,;-4.67,-3.85,;-4.67,-2.31,;-3.33,-1.54,;-3.33,,;-2,.77,;-.67,,;-.67,-1.54,;.67,-2.31,;.67,-3.85,;2,-1.54,;3.33,-2.31,;3.33,-3.85,;4.67,-4.62,;6,-3.85,;6,-2.31,;4.67,-1.54,;4.67,,;2,,;3.33,.77,;3.33,2.31,;2,3.08,;.67,2.31,;.67,.77,;4.67,3.08,;6,2.31,;4.67,4.62,;4.67,1.54,;-4.67,.77,;-6,,;-6,-1.54,)|	InChI=1S/C20H13ClF3N5O2/c1-31-16-10-11(8-9-25-16)26-17-12-6-7-15(20(22,23)24)27-18(12)29(19(30)28-17)14-5-3-2-4-13(14)21/h2-10H,1H3,(H,25,26,28,30)	GIDPXYZCEDAJSW-UHFFFAOYSA-N	508311	US11130759, Cpd. No. 622::US11046691, Compound 622::1-(2-chlorophenyl)-4-((2-methoxy- pyridin-4-yl)amino)-7- (trifluoromethyl)-pyrido-[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 622	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508311&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608871	459093387							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072166	Cc1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3nc(ccc23)C(F)(F)F)ccn1 |(-4.67,-3.85,;-4.67,-2.31,;-3.33,-1.54,;-3.33,,;-2,.77,;-.67,,;-.67,-1.54,;.67,-2.31,;.67,-3.85,;2,-1.54,;3.33,-2.31,;3.33,-3.85,;4.67,-4.62,;6,-3.85,;6,-2.31,;4.67,-1.54,;4.67,,;2,,;3.33,.77,;3.33,2.31,;2,3.08,;.67,2.31,;.67,.77,;4.67,3.08,;6,2.31,;4.67,4.62,;4.67,1.54,;-4.67,.77,;-6,,;-6,-1.54,)|	InChI=1S/C20H13ClF3N5O/c1-11-10-12(8-9-25-11)26-17-13-6-7-16(20(22,23)24)27-18(13)29(19(30)28-17)15-5-3-2-4-14(15)21/h2-10H,1H3,(H,25,26,28,30)	ZMODQMMARRVLGE-UHFFFAOYSA-N	508312	US11130759, Cpd. No. 623::US11046691, Compound 623::1-(2-chlorophenyl)-4-((2- methylpyridin-4-yl)amino)-7- (trifluoromethyl)-pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 623	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508312&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149530632	459093388							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072167	CCc1ccc2c(NC)nc(=O)n(-c3ccccc3F)c2n1 |(4.67,3.08,;3.33,3.85,;2,3.08,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-3.33,1.54,;-4.67,.77,;-2,-.77,;-.67,-1.54,;-.67,-3.08,;.67,-.77,;2,-1.54,;2,-3.08,;3.33,-3.85,;4.67,-3.08,;4.67,-1.54,;3.33,-.77,;3.33,.77,;.67,.77,;2,1.54,)|	InChI=1S/C16H15FN4O/c1-3-10-8-9-11-14(18-2)20-16(22)21(15(11)19-10)13-7-5-4-6-12(13)17/h4-9H,3H2,1-2H3,(H,18,20,22)	YAXOITUWCNWFCJ-UHFFFAOYSA-N	508313	US11130759, Cpd. No. 624::US11046691, Compound 624::7-ethyl-1-(2-fluorophenyl)-4-(methyl- amino)pyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 624	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508313	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508313&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152488318	459093389							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072168	CCc1ccc2c(NC)nc(=O)n(-c3ccccc3Cl)c2n1 |(4.67,3.08,;3.33,3.85,;2,3.08,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-3.33,1.54,;-4.67,.77,;-2,-.77,;-.67,-1.54,;-.67,-3.08,;.67,-.77,;2,-1.54,;2,-3.08,;3.33,-3.85,;4.67,-3.08,;4.67,-1.54,;3.33,-.77,;3.33,.77,;.67,.77,;2,1.54,)|	InChI=1S/C16H15ClN4O/c1-3-10-8-9-11-14(18-2)20-16(22)21(15(11)19-10)13-7-5-4-6-12(13)17/h4-9H,3H2,1-2H3,(H,18,20,22)	XINOITLMUCEWMU-UHFFFAOYSA-N	508314	US11130759, Cpd. No. 625::US11046691, Compound 625::1-(2-chlorophenyl)-7-ethyl-4-(methyl- amino)pyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 625	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508314&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608805	459093390							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072169	CCc1ccc2c(NC)nc(=O)n(-c3ccccc3C)c2n1 |(4.67,3.08,;3.33,3.85,;2,3.08,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-3.33,1.54,;-4.67,.77,;-2,-.77,;-.67,-1.54,;-.67,-3.08,;.67,-.77,;2,-1.54,;2,-3.08,;3.33,-3.85,;4.67,-3.08,;4.67,-1.54,;3.33,-.77,;3.33,.77,;.67,.77,;2,1.54,)|	InChI=1S/C17H18N4O/c1-4-12-9-10-13-15(18-3)20-17(22)21(16(13)19-12)14-8-6-5-7-11(14)2/h5-10H,4H2,1-3H3,(H,18,20,22)	YYTWIQGQAJWAEB-UHFFFAOYSA-N	508315	US11130759, Cpd. No. 626::US11046691, Compound 626::7-ethyl-4-(methylamino)-1-(o-tolyl)- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 626	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508315&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152607241	459093391							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072170	CCc1ccc2c(NC)nc(=O)n(-c3ccccc3)c2n1	InChI=1S/C16H16N4O/c1-3-11-9-10-13-14(17-2)19-16(21)20(15(13)18-11)12-7-5-4-6-8-12/h4-10H,3H2,1-2H3,(H,17,19,21)	SKRLFKARRACCLS-UHFFFAOYSA-N	508316	US11130759, Cpd. No. 627::US11046691, Compound 627::7-ethyl-4-(methylamino)-1-phenyl- pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 627	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508316&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151860847	459093392							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072171	Cc1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3nc(ccc23)C(F)(F)F)no1 |(-6.65,-.36,;-5.12,-.52,;-4.09,.63,;-2.68,,;-1.35,.77,;-.02,,;-.02,-1.54,;1.32,-2.31,;1.32,-3.85,;2.65,-1.54,;3.98,-2.31,;3.98,-3.85,;5.32,-4.62,;6.65,-3.85,;6.65,-2.31,;5.32,-1.54,;5.32,,;2.65,,;3.98,.77,;3.98,2.31,;2.65,3.08,;1.32,2.31,;1.32,.77,;5.32,3.08,;6.65,2.31,;5.32,4.62,;5.32,1.54,;-2.84,-1.53,;-4.35,-1.85,)|	InChI=1S/C18H11ClF3N5O2/c1-9-8-14(26-29-9)24-15-10-6-7-13(18(20,21)22)23-16(10)27(17(28)25-15)12-5-3-2-4-11(12)19/h2-8H,1H3,(H,24,25,26,28)	GXYKMIPOKVGTRW-UHFFFAOYSA-N	508317	US11130759, Cpd. No. 628::US11046691, Compound 628::1-(2-chlorophenyl)-4-((5-methyl- isoxazol-3-yl)amino)-7-(trifluoro- methyl)pyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 628	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508317	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508317&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608271	459093393							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072172	FC(F)(F)c1ccc2c(Nc3cnoc3)nc(=O)n(-c3ccccc3Cl)c2n1 |(5.89,2.31,;4.55,3.08,;4.55,4.62,;4.55,1.54,;3.22,2.31,;1.89,3.08,;.55,2.31,;.55,.77,;-.78,,;-2.12,.77,;-3.45,,;-3.61,-1.53,;-5.12,-1.85,;-5.89,-.52,;-4.86,.63,;-.78,-1.54,;.55,-2.31,;.55,-3.85,;1.89,-1.54,;3.22,-2.31,;3.22,-3.85,;4.55,-4.62,;5.89,-3.85,;5.89,-2.31,;4.55,-1.54,;4.55,,;1.89,,;3.22,.77,)|	InChI=1S/C17H9ClF3N5O2/c18-11-3-1-2-4-12(11)26-15-10(5-6-13(24-15)17(19,20)21)14(25-16(26)27)23-9-7-22-28-8-9/h1-8H,(H,23,25,27)	BQLONWQKYDQPOV-UHFFFAOYSA-N	508318	US11130759, Cpd. No. 629::US11046691, Compound 629::1-(2-chlorophenyl)-4-(isoxazol-4-yl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 629	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508318&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608378	459093394							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072173	Cn1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3nc(ccc23)C(F)(F)F)cn1 |(-6.65,-.36,;-5.12,-.52,;-4.09,.63,;-2.68,,;-1.35,.77,;-.02,,;-.02,-1.54,;1.32,-2.31,;1.32,-3.85,;2.65,-1.54,;3.98,-2.31,;3.98,-3.85,;5.32,-4.62,;6.65,-3.85,;6.65,-2.31,;5.32,-1.54,;5.32,,;2.65,,;3.98,.77,;3.98,2.31,;2.65,3.08,;1.32,2.31,;1.32,.77,;5.32,3.08,;6.65,2.31,;5.32,4.62,;5.32,1.54,;-2.84,-1.53,;-4.35,-1.85,)|	InChI=1S/C18H12ClF3N6O/c1-27-9-10(8-23-27)24-15-11-6-7-14(18(20,21)22)25-16(11)28(17(29)26-15)13-5-3-2-4-12(13)19/h2-9H,1H3,(H,24,26,29)	MZBMWMJZMDXFEE-UHFFFAOYSA-N	508319	US11130759, Cpd. No. 630::US11046691, Compound 630::1-(2-chlorophenyl)-4-((1-methyl-1H- pyrazol-4-yflamino)-7- (trifluoromethyl)-pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 630	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508319&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608793	459093395							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072174	Cn1ccc(Nc2nc(=O)n(-c3ccccc3Cl)c3nc(ccc23)C(F)(F)F)n1 |(-5.74,-3.26,;-5.12,-1.85,;-5.89,-.52,;-4.86,.63,;-3.45,,;-2.12,.77,;-.78,,;-.78,-1.54,;.55,-2.31,;.55,-3.85,;1.89,-1.54,;3.22,-2.31,;3.22,-3.85,;4.55,-4.62,;5.89,-3.85,;5.89,-2.31,;4.55,-1.54,;4.55,,;1.89,,;3.22,.77,;3.22,2.31,;1.89,3.08,;.55,2.31,;.55,.77,;4.55,3.08,;5.89,2.31,;4.55,4.62,;4.55,1.54,;-3.61,-1.53,)|	InChI=1S/C18H12ClF3N6O/c1-27-9-8-14(26-27)24-15-10-6-7-13(18(20,21)22)23-16(10)28(17(29)25-15)12-5-3-2-4-11(12)19/h2-9H,1H3,(H,24,25,26,29)	VXIZAJBSDBTRMZ-UHFFFAOYSA-N	508320	US11130759, Cpd. No. 631::US11046691, Compound 631::1-(2-chlorophenyl)-4-((1-methyl-1H- pyrazol-3-yflamino)-7-(trifluoro- methyl)pyrido-[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 631	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508320&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609058	459093396							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072175	Cn1cnc(Nc2nc(=O)n(-c3ccccc3Cl)c3nc(ccc23)C(F)(F)F)c1 |(-6.65,-.36,;-5.12,-.52,;-4.35,-1.85,;-2.84,-1.53,;-2.68,,;-1.35,.77,;-.02,,;-.02,-1.54,;1.32,-2.31,;1.32,-3.85,;2.65,-1.54,;3.98,-2.31,;3.98,-3.85,;5.32,-4.62,;6.65,-3.85,;6.65,-2.31,;5.32,-1.54,;5.32,,;2.65,,;3.98,.77,;3.98,2.31,;2.65,3.08,;1.32,2.31,;1.32,.77,;5.32,3.08,;6.65,2.31,;5.32,4.62,;5.32,1.54,;-4.09,.63,)|	InChI=1S/C18H12ClF3N6O/c1-27-8-14(23-9-27)25-15-10-6-7-13(18(20,21)22)24-16(10)28(17(29)26-15)12-5-3-2-4-11(12)19/h2-9H,1H3,(H,25,26,29)	ANUNMRFUJQEMTD-UHFFFAOYSA-N	508321	US11130759, Cpd. No. 632::US11046691, Compound 632::1-(2-chlorophenyl)-4-((1-methyl-1H- imidazol-4-yl)amino)-7-(trifluoro- methyl)-pyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 632	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508321&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608751	459093397							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072176	Cn1nccc1Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(-2.47,-2.56,;-3.61,-1.53,;-5.12,-1.85,;-5.89,-.52,;-4.86,.63,;-3.45,,;-2.12,.77,;-.78,,;-.78,-1.54,;.55,-2.31,;.55,-3.85,;1.89,-1.54,;3.22,-2.31,;3.22,-3.85,;4.55,-4.62,;5.89,-3.85,;5.89,-2.31,;4.55,-1.54,;4.55,,;1.89,,;3.22,.77,;3.22,2.31,;1.89,3.08,;.55,2.31,;.55,.77,;4.55,3.08,;5.89,2.31,;4.55,4.62,;4.55,1.54,)|	InChI=1S/C18H12ClF3N6O/c1-27-14(8-9-23-27)25-15-10-6-7-13(18(20,21)22)24-16(10)28(17(29)26-15)12-5-3-2-4-11(12)19/h2-9H,1H3,(H,25,26,29)	DGLMUXOMXVHCFJ-UHFFFAOYSA-N	508322	US11130759, Cpd. No. 633::US11046691, Compound 633::1-(2-chlorophenyl)-4-((1-methyl-1H- pyrazol-5-yl)amino)-7- (trifluoromethyl)-pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 633	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508322	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508322&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608239	459093398							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072177	FC(F)(F)c1ccc2c(Nc3cccnc3)nc(=O)n(-c3ccccc3Cl)c2n1 |(6,2.31,;4.67,3.08,;4.67,4.62,;4.67,1.54,;3.33,2.31,;2,3.08,;.67,2.31,;.67,.77,;-.67,,;-2,.77,;-3.33,,;-4.67,.77,;-6,,;-6,-1.54,;-4.67,-2.31,;-3.33,-1.54,;-.67,-1.54,;.67,-2.31,;.67,-3.85,;2,-1.54,;3.33,-2.31,;3.33,-3.85,;4.67,-4.62,;6,-3.85,;6,-2.31,;4.67,-1.54,;4.67,,;2,,;3.33,.77,)|	InChI=1S/C19H11ClF3N5O/c20-13-5-1-2-6-14(13)28-17-12(7-8-15(26-17)19(21,22)23)16(27-18(28)29)25-11-4-3-9-24-10-11/h1-10H,(H,25,27,29)	VHNFCZDLFXXJOZ-UHFFFAOYSA-N	508323	US11130759, Cpd. No. 634::US11046691, Compound 634::1-(2-chlorophenyl)-4-(pyridin-3-yl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11084798, Cpd No 634	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508323&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153050831	459093399							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072178	CNc1nc(=O)n(-c2ccccc2F)c2nc(ccc12)C(F)(F)F |(-4.67,,;-3.33,.77,;-2,,;-2,-1.54,;-.67,-2.31,;-.67,-3.85,;.67,-1.54,;2,-2.31,;2,-3.85,;3.33,-4.62,;4.67,-3.85,;4.67,-2.31,;3.33,-1.54,;3.33,,;.67,,;2,.77,;2,2.31,;.67,3.08,;-.67,2.31,;-.67,.77,;3.33,3.08,;4.67,2.31,;3.33,4.62,;3.33,1.54,)|	InChI=1S/C15H10F4N4O/c1-20-12-8-6-7-11(15(17,18)19)21-13(8)23(14(24)22-12)10-5-3-2-4-9(10)16/h2-7H,1H3,(H,20,22,24)	JGIUMLQLGYABOK-UHFFFAOYSA-N	508324	US11130759, Cpd. No. 635::US11046691, Compound 635::1-(2-fluorophenyl)-4-(methylamino)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 635	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508324&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608795	459093400							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072179	CNc1nc(=O)n(-c2ccccc2Br)c2nc(ccc12)C(F)(F)F |(-4.67,,;-3.33,.77,;-2,,;-2,-1.54,;-.67,-2.31,;-.67,-3.85,;.67,-1.54,;2,-2.31,;2,-3.85,;3.33,-4.62,;4.67,-3.85,;4.67,-2.31,;3.33,-1.54,;3.33,,;.67,,;2,.77,;2,2.31,;.67,3.08,;-.67,2.31,;-.67,.77,;3.33,3.08,;4.67,2.31,;3.33,4.62,;3.33,1.54,)|	InChI=1S/C15H10BrF3N4O/c1-20-12-8-6-7-11(15(17,18)19)21-13(8)23(14(24)22-12)10-5-3-2-4-9(10)16/h2-7H,1H3,(H,20,22,24)	FRAVEQOPTCJAPO-UHFFFAOYSA-N	508325	US11130759, Cpd. No. 636::US11046691, Compound 636::1-(2-bromophenyl)-4-(methylamino)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 636	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508325&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608284	459093401							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072180	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F |r|	InChI=1S/C18H15F3N4O2/c19-18(20,21)14-7-6-13-15(24-9-8-12(26)10-24)23-17(27)25(16(13)22-14)11-4-2-1-3-5-11/h1-7,12,26H,8-10H2	PGZOPGOLOUBEAJ-UHFFFAOYSA-N	508043	US11130759, Cpd. No. 637::US11046691, Compound 637::(R)-4-(3-hydroxypyrrolidin-1-yl)-1- phenyl-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11046691, Compound 170::US11084798, Cpd No 637	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508043&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608617	459093123							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072181	Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-4.1,.87,;-2.77,.1,;-2.77,-1.44,;-1.44,-2.21,;-1.44,-3.75,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-4.52,;3.9,-3.75,;3.9,-2.21,;2.56,-1.44,;2.56,.1,;-.1,.1,;1.23,.87,;1.23,2.41,;-.1,3.18,;-1.44,2.41,;-1.44,.87,;2.56,3.18,;4.1,3.18,;3.33,4.52,)|	InChI=1S/C17H14ClN3O/c18-13-3-1-2-4-14(13)21-15-9-11(10-5-6-10)7-8-12(15)16(19)20-17(21)22/h1-4,7-10H,5-6H2,(H2,19,20,22)	MMADPJCVOASEJQ-UHFFFAOYSA-N	508327	US11130759, Cpd. No. 638::US11046691, Compound 638::4-amino-1-(2-chlorophenyl)-7- cyclopropylquinazolin-2(1H)-one::US11084798, Cpd No 638	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508327&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151090480	459093402							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072182	CC(C)Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |(-5.16,1.44,;-4.39,.1,;-4.78,-1.38,;-3.05,.87,;-1.72,.1,;-1.72,-1.44,;-.38,-2.21,;-.38,-3.75,;.95,-1.44,;2.28,-2.21,;2.28,-3.75,;3.62,-4.52,;4.95,-3.75,;4.95,-2.21,;3.62,-1.44,;3.62,.1,;.95,.1,;2.28,.87,;2.28,2.41,;.95,3.18,;-.38,2.41,;-.38,.87,;3.62,3.18,;5.16,3.18,;4.39,4.52,)|	InChI=1S/C20H20ClN3O/c1-12(2)22-19-15-10-9-14(13-7-8-13)11-18(15)24(20(25)23-19)17-6-4-3-5-16(17)21/h3-6,9-13H,7-8H2,1-2H3,(H,22,23,25)	VXJOETNMUBNHDH-UHFFFAOYSA-N	508328	US11130759, Cpd. No. 639::US11046691, Compound 639::1-(2-chlorophenyl)-7-cyclopropyl-4- (isopropylamino)quinazolin-2(1H)-one::US11084798, Cpd No 639	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508328&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608628	459093403							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072183	F[C@@H]1CC1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |r,wD:1.0,(-4.77,-2.77,;-4.77,-1.23,;-5.54,.1,;-4,.1,;-2.67,.87,;-1.33,.1,;-1.33,-1.44,;,-2.21,;,-3.75,;1.33,-1.44,;2.67,-2.21,;2.67,-3.75,;4,-4.52,;5.33,-3.75,;5.33,-2.21,;4,-1.44,;4,.1,;1.33,.1,;2.67,.87,;2.67,2.41,;1.33,3.18,;,2.41,;,.87,;4,3.18,;5.54,3.18,;4.77,4.52,)|	InChI=1S/C20H17ClFN3O/c21-14-3-1-2-4-17(14)25-18-9-12(11-5-6-11)7-8-13(18)19(24-20(25)26)23-16-10-15(16)22/h1-4,7-9,11,15-16H,5-6,10H2,(H,23,24,26)	OFKNVVVDSFLNGX-UHFFFAOYSA-N	508329	US11046691, Compound 640::1-(2-chlorophenyl)-7-cyclopropyl-4- (((1S,2R)-2-fluorocyclopropyl)amino)- quinazolin-2(1H)-one::US11084798, Cpd No 640	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508329&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933497	459093404							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072184	Clc1ccccc1-n1c2cc(ccc2c(Nc2cnoc2)nc1=O)C1CC1 |(4.45,.1,;4.45,-1.44,;5.78,-2.21,;5.78,-3.75,;4.45,-4.52,;3.12,-3.75,;3.12,-2.21,;1.78,-1.44,;1.78,.1,;3.12,.87,;3.12,2.41,;1.78,3.18,;.45,2.41,;.45,.87,;-.88,.1,;-2.22,.87,;-3.55,.1,;-3.71,-1.43,;-5.22,-1.75,;-5.99,-.41,;-4.96,.73,;-.88,-1.44,;.45,-2.21,;.45,-3.75,;4.45,3.18,;5.99,3.18,;5.22,4.52,)|	InChI=1S/C20H15ClN4O2/c21-16-3-1-2-4-17(16)25-18-9-13(12-5-6-12)7-8-15(18)19(24-20(25)26)23-14-10-22-27-11-14/h1-4,7-12H,5-6H2,(H,23,24,26)	PWJDERZZSYANCM-UHFFFAOYSA-N	508330	US11046691, Compound 641::1-(2-chlorophenyl)-7-cyclopropyl-4- (isoxazol-4-ylamino)quinazolin-2(1H)- one::US11084798, Cpd No 641	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508330&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608329	459093405							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072185	Clc1ccccc1-n1c2cc(ccc2c(Nc2cnsc2)nc1=O)C1CC1 |(4.45,.1,;4.45,-1.44,;5.78,-2.21,;5.78,-3.75,;4.45,-4.52,;3.12,-3.75,;3.12,-2.21,;1.78,-1.44,;1.78,.1,;3.12,.87,;3.12,2.41,;1.78,3.18,;.45,2.41,;.45,.87,;-.88,.1,;-2.22,.87,;-3.55,.1,;-3.71,-1.43,;-5.22,-1.75,;-5.99,-.41,;-4.96,.73,;-.88,-1.44,;.45,-2.21,;.45,-3.75,;4.45,3.18,;5.99,3.18,;5.22,4.52,)|	InChI=1S/C20H15ClN4OS/c21-16-3-1-2-4-17(16)25-18-9-13(12-5-6-12)7-8-15(18)19(24-20(25)26)23-14-10-22-27-11-14/h1-4,7-12H,5-6H2,(H,23,24,26)	VWXORMVPSIUAAO-UHFFFAOYSA-N	508331	US11130759, Cpd. No. 642::US11046691, Compound 642::1-(2-chlorophenyl)-7-cyclopropyl-4- (isothiazol-4-ylamino)quinazolin- 2(1H)-one::US11084798, Cpd No 642	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508331&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608313	459093406							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072186	FC(F)(F)c1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(ccc23)C2CC2)ccn1 |(-4.67,-4.96,;-4.67,-3.42,;-6.21,-3.42,;-3.13,-3.42,;-4.67,-1.88,;-3.33,-1.05,;-3.33,.49,;-2,1.26,;-.67,.49,;-.67,-1.05,;.67,-1.82,;.67,-3.36,;2,-1.05,;3.33,-1.82,;3.33,-3.36,;4.67,-4.13,;6,-3.36,;6,-1.82,;4.67,-1.05,;4.67,.49,;2,.49,;3.33,1.26,;3.33,2.8,;2,3.57,;.67,2.8,;.67,1.26,;4.67,3.57,;6.21,3.57,;5.44,4.9,;-4.67,1.26,;-6,.49,;-6,-1.05,)|	InChI=1S/C23H16ClF3N4O/c24-17-3-1-2-4-18(17)31-19-11-14(13-5-6-13)7-8-16(19)21(30-22(31)32)29-15-9-10-28-20(12-15)23(25,26)27/h1-4,7-13H,5-6H2,(H,28,29,30,32)	VQKPWTGMHHLWTB-UHFFFAOYSA-N	508332	US11130759, Cpd. No. 643::US11046691, Compound 643::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2-(trifluoromethyl)pyridin-4- yl)amino)-quinazolin-2(1H)-one::US11084798, Cpd No 643	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508332&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608429	459093407							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072187	CNc1nc(=O)n(-c2cccc3nccn23)c2cc(ccc12)C1CC1 |(-5.24,.1,;-3.91,.87,;-2.57,.1,;-2.57,-1.44,;-1.24,-2.21,;-1.24,-3.75,;.09,-1.44,;1.43,-2.21,;1.43,-3.75,;2.76,-4.52,;4.1,-3.75,;4.1,-2.21,;5.24,-1.18,;4.61,.23,;3.08,.07,;2.76,-1.44,;.09,.1,;1.43,.87,;1.43,2.41,;.09,3.18,;-1.24,2.41,;-1.24,.87,;2.76,3.18,;4.3,3.18,;3.53,4.52,)|	InChI=1S/C19H17N5O/c1-20-18-14-8-7-13(12-5-6-12)11-15(14)24(19(25)22-18)17-4-2-3-16-21-9-10-23(16)17/h2-4,7-12H,5-6H2,1H3,(H,20,22,25)	YUOCDJMGLAJOPE-UHFFFAOYSA-N	508333	US11130759, Cpd. No. 644::US11046691, Compound 644::7-cyclopropyl-1-(imidazo[1,2- a]pyridin-5-yl)-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 644	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508333&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608765	459093408							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072188	O=c1nc(NCC2CC2)c2ccc(cc2n1-c1cnccn1)C1CC1	InChI=1S/C19H19N5O/c25-19-23-18(22-10-12-1-2-12)15-6-5-14(13-3-4-13)9-16(15)24(19)17-11-20-7-8-21-17/h5-9,11-13H,1-4,10H2,(H,22,23,25)	DRYCZZATCZKGOK-UHFFFAOYSA-N	508334	US11130759, Cpd. No. 645::US11046691, Compound 645::7-cyclopropyl-4-((cyclopropylmethyl)- amino)-1-(pyrazin-2-yl)quinazolin- 2(1H)-one::US11084798, Cpd No 645	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508334&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150084509	459093409							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072189	CNc1nc(=O)n(-c2nccnc2C)c2cc(ccc12)C1CC1 |(-4.77,.1,;-3.44,.87,;-2.1,.1,;-2.1,-1.44,;-.77,-2.21,;-.77,-3.75,;.56,-1.44,;1.9,-2.21,;1.9,-3.75,;3.23,-4.52,;4.56,-3.75,;4.56,-2.21,;3.23,-1.44,;3.23,.1,;.56,.1,;1.9,.87,;1.9,2.41,;.56,3.18,;-.77,2.41,;-.77,.87,;3.23,3.18,;4.77,3.18,;4,4.52,)|	InChI=1S/C17H17N5O/c1-10-16(20-8-7-19-10)22-14-9-12(11-3-4-11)5-6-13(14)15(18-2)21-17(22)23/h5-9,11H,3-4H2,1-2H3,(H,18,21,23)	HCEZNUUZZKRMCD-UHFFFAOYSA-N	508335	US11130759, Cpd. No. 646::US11046691, Compound 646::7-cyclopropyl-4-(methylamino)-1-(3- methylpyrazin-2-yl)quinazolin-2(1H)- one::US11084798, Cpd No 646	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508335&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150393495	459093410							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072190	Cc1nccnc1-n1c2cc(ccc2c(NCC2CC2)nc1=O)C1CC1 |(4.67,.1,;4.67,-1.44,;6,-2.21,;6,-3.75,;4.67,-4.52,;3.33,-3.75,;3.33,-2.21,;2,-1.44,;2,.1,;3.33,.87,;3.33,2.41,;2,3.18,;.67,2.41,;.67,.87,;-.67,.1,;-2,.87,;-3.33,.1,;-4.67,.87,;-5.44,2.21,;-6.21,.87,;-.67,-1.44,;.67,-2.21,;.67,-3.75,;4.67,3.18,;6.21,3.18,;5.44,4.52,)|	InChI=1S/C20H21N5O/c1-12-19(22-9-8-21-12)25-17-10-15(14-4-5-14)6-7-16(17)18(24-20(25)26)23-11-13-2-3-13/h6-10,13-14H,2-5,11H2,1H3,(H,23,24,26)	PROVFFVPCLSHRW-UHFFFAOYSA-N	508336	US11130759, Cpd. No. 647::US11046691, Compound 647::7-cyclopropyl-4-((cyclopropylmethyl)- amino)-1-(3-methylpyrazin-2-yl)- quinazolin-2(1H)-one::US11084798, Cpd No 647	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508336&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151506721	459093411							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072191	CNc1nc(=O)n(-c2ccn3ccnc3c2)c2cc(ccc12)C1CC1	InChI=1S/C19H17N5O/c1-20-18-15-5-4-13(12-2-3-12)10-16(15)24(19(25)22-18)14-6-8-23-9-7-21-17(23)11-14/h4-12H,2-3H2,1H3,(H,20,22,25)	KIZZOPVHXFSVJY-UHFFFAOYSA-N	508337	US11130759, Cpd. No. 648::US11046691, Compound 648::7-cyclopropyl-1-(imidazo[1,2- alpyridin-7-yl)-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 648	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508337	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508337&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608542	459093412							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072192	CNc1nc(=O)n(-c2cccnc2C(F)(F)F)c2cc(cc(OC)c12)C(F)(F)F |(-4.77,,;-3.44,.77,;-2.1,,;-2.1,-1.54,;-.77,-2.31,;-.77,-3.85,;.56,-1.54,;1.9,-2.31,;1.9,-3.85,;3.23,-4.62,;4.56,-3.85,;4.56,-2.31,;3.23,-1.48,;3.23,.06,;3.23,1.6,;1.69,.06,;4.77,.06,;.56,,;1.9,.77,;1.9,2.31,;.56,3.08,;-.77,2.31,;-2.1,3.08,;-2.1,4.62,;-.77,.77,;3.23,3.08,;4.56,3.85,;2.46,4.41,;4,1.75,)|	InChI=1S/C17H12F6N4O2/c1-24-14-12-10(6-8(16(18,19)20)7-11(12)29-2)27(15(28)26-14)9-4-3-5-25-13(9)17(21,22)23/h3-7H,1-2H3,(H,24,26,28)	ACLBSYNDJHAMKR-UHFFFAOYSA-N	508338	US11130759, Cpd. No. 649::US11046691, Compound 649::5-methoxy-4-(methylamino)-7- (trifluoromethyl)-1-(2- (trifluoromethyl)-pyridin-3- yl)quinazolin-2(1H)-one::US11084798, Cpd No 649	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508338&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608425	459093413							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072193	Fc1cc(cc2n(-c3cccnc3C(F)(F)F)c(=O)nc(NCC3CC3)c12)C(F)(F)F |(-.67,3.18,;.67,2.41,;2,3.18,;3.33,2.41,;3.33,.87,;2,.1,;2,-1.44,;3.33,-2.21,;3.33,-3.75,;4.67,-4.52,;6,-3.75,;6,-2.21,;4.67,-1.38,;4.67,.16,;4.67,1.7,;3.13,.16,;6.21,.16,;.67,-2.21,;.67,-3.75,;-.67,-1.44,;-.67,.1,;-2,.87,;-3.33,.1,;-4.67,.87,;-5.44,2.21,;-6.21,.87,;.67,.87,;4.67,3.18,;6,3.95,;3.9,4.52,;5.44,1.85,)|	InChI=1S/C19H13F7N4O/c20-11-6-10(18(21,22)23)7-13-14(11)16(28-8-9-3-4-9)29-17(31)30(13)12-2-1-5-27-15(12)19(24,25)26/h1-2,5-7,9H,3-4,8H2,(H,28,29,31)	YIZRFKAPTOSUAP-UHFFFAOYSA-N	508339	US11130759, Cpd. No. 650::US11046691, Compound 650::4-((cyclopropylmethyl)amino)-5-fluoro- 7-(trifluoromethyl)-1-(2-(trifluoro- methyl)-pyridin-3-yl)quinazolin-2(1H)- one::US11084798, Cpd No 650	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508339&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152528344	459093414							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072194	Nc1nc(=O)n(-c2ccn3ccnc3c2)c2cc(Cl)ccc12	InChI=1S/C15H10ClN5O/c16-9-1-2-11-12(7-9)21(15(22)19-14(11)17)10-3-5-20-6-4-18-13(20)8-10/h1-8H,(H2,17,19,22)	QCZQIJWWJBMSCM-UHFFFAOYSA-N	508340	US11130759, Cpd. No. 651::US11046691, Compound 651::4-amino-7-chloro-1-(imidazo[1,2-a]- pyridin-7-yl)quinazolin-2(1H)-one::US11084798, Cpd No 651	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508340&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933695	459093415							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072195	CNc1nc(=O)n(-c2ccn3ccnc3c2)c2cc(Cl)ccc12	InChI=1S/C16H12ClN5O/c1-18-15-12-3-2-10(17)8-13(12)22(16(23)20-15)11-4-6-21-7-5-19-14(21)9-11/h2-9H,1H3,(H,18,20,23)	YHEZBWIJICBJMI-UHFFFAOYSA-N	508341	US11130759, Cpd. No. 652::US11046691, Compound 652::7-chloro-1-(imidazo[1,2-a]pyridin-7- yl)-4-(methylamino)quinazolin-2(1H)- one::US11084798, Cpd No 652	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508341	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508341&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608465	459093416							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072196	FC(F)CNc1nc(=O)n(-c2ccn3ccnc3c2)c2cc(Cl)ccc12	InChI=1S/C17H12ClF2N5O/c18-10-1-2-12-13(7-10)25(17(26)23-16(12)22-9-14(19)20)11-3-5-24-6-4-21-15(24)8-11/h1-8,14H,9H2,(H,22,23,26)	JDGRXRBVTSERAZ-UHFFFAOYSA-N	508342	US11130759, Cpd. No. 653::US11046691, Compound 653::7-chloro-4-((2,2-difluoroethyl)amino)- 1-(imidazo[1,2-a]pyridin-7- yl)quinazolin-2(1H)-one::US11084798, Cpd No 653	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508342	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508342&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608630	459093417							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072197	CNc1nc(=O)n(-c2cccc3nccn23)c2cc(Cl)ccc12 |(,5,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.38,;1.33,-.39,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;-1.46,-4.71,;-2.37,-3.47,;-1.46,-2.22,;,-2.69,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-2.67,1.93,;-1.33,2.69,;,1.92,)|	InChI=1S/C16H12ClN5O/c1-18-15-11-6-5-10(17)9-12(11)22(16(23)20-15)14-4-2-3-13-19-7-8-21(13)14/h2-9H,1H3,(H,18,20,23)	DVZQPELBJMMJOO-UHFFFAOYSA-N	508343	US11130759, Cpd. No. 654::US11046691, Compound 654::7-chloro-1-(imidazo[1,2-a]pyridin-5- yl)-4-(methylamino)quinazolin-2(1H)- one::US11084798, Cpd No 654	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508343&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147439779	459093418							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072198	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |(2,5,;3.33,4.23,;3.33,2.69,;4.67,1.92,;4.67,.38,;6,-.38,;3.33,-.39,;3.33,-1.93,;4.67,-2.69,;4.67,-4.23,;3.33,-5,;2,-4.23,;2,-2.69,;.67,-1.92,;2,.38,;.67,-.38,;-.71,.36,;-2.05,-.41,;-3.38,.36,;-4.72,-.41,;-3.38,1.9,;-3.38,-1.18,;-.67,1.93,;.67,2.69,;2,1.92,)|	InChI=1S/C16H11ClF3N3O2/c1-21-14-10-7-6-9(25-16(18,19)20)8-13(10)23(15(24)22-14)12-5-3-2-4-11(12)17/h2-8H,1H3,(H,21,22,24)	KYOFAFABPIFFAV-UHFFFAOYSA-N	508344	US11046691, Compound 655::1-(2-chlorophenyl)-4-(methylamino)-7- (trifluoromethoxy)quinazolin-2(1H)- one::BDBM512319	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508344	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508344&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608237	459093419							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072199	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(C)(F)F |(.62,5.03,;1.95,4.26,;1.95,2.72,;3.29,1.95,;3.29,.41,;4.62,-.36,;1.95,-.36,;1.95,-1.9,;.62,-2.67,;.62,-4.21,;1.95,-4.98,;3.29,-4.21,;3.29,-2.67,;4.62,-1.9,;.62,.41,;-.72,-.36,;-2.05,.41,;-2.05,1.95,;-.72,2.72,;.62,1.95,;-3.38,-.36,;-2.61,-1.7,;-4.72,-1.13,;-4.15,.97,)|	InChI=1S/C17H14ClF2N3O/c1-17(19,20)10-7-8-11-14(9-10)23(16(24)22-15(11)21-2)13-6-4-3-5-12(13)18/h3-9H,1-2H3,(H,21,22,24)	HGDJUJKASVUOHN-UHFFFAOYSA-N	508347	US11130759, Cpd. No. 658::US11046691, Compound 658::1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 658	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508347	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508347&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147772151	459093422							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072200	CC(F)(F)c1ccc2c(Nc3cnoc3)nc(=O)n(-c3ccccc3Cl)c2c1 |(-4.78,.04,;-4.01,-1.29,;-5.34,-2.06,;-3.24,-2.62,;-2.67,-.52,;-2.67,1.02,;-1.34,1.79,;-.01,1.02,;1.33,1.79,;1.33,3.33,;2.66,4.1,;4.07,3.47,;5.1,4.62,;4.33,5.95,;2.82,5.63,;2.66,1.02,;2.66,-.52,;3.99,-1.29,;1.33,-1.29,;1.33,-2.83,;-.01,-3.6,;-.01,-5.14,;1.33,-5.91,;2.66,-5.14,;2.66,-3.6,;3.99,-2.83,;-.01,-.52,;-1.34,-1.29,)|	InChI=1S/C19H13ClF2N4O2/c1-19(21,22)11-6-7-13-16(8-11)26(15-5-3-2-4-14(15)20)18(27)25-17(13)24-12-9-23-28-10-12/h2-10H,1H3,(H,24,25,27)	MNRIQDZBFRWIPE-UHFFFAOYSA-N	508346	US11130759, Cpd. No. 657::US11046691, Compound 657::1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4-(isoxazol-4- ylamino)quinazolin-2(1H)-one::US11084798, Cpd No 657	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508346&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608968	459093421							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072201	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(C)(F)F |(.62,5.03,;1.95,4.26,;1.95,2.72,;3.29,1.95,;3.29,.41,;4.62,-.36,;1.95,-.36,;1.95,-1.9,;.62,-2.67,;.62,-4.21,;1.95,-4.98,;3.29,-4.21,;3.29,-2.67,;4.62,-1.9,;.62,.41,;-.72,-.36,;-2.05,.41,;-2.05,1.95,;-.72,2.72,;.62,1.95,;-3.38,-.36,;-2.61,-1.7,;-4.72,-1.13,;-4.15,.97,)|	InChI=1S/C17H14ClF2N3O/c1-17(19,20)10-7-8-11-14(9-10)23(16(24)22-15(11)21-2)13-6-4-3-5-12(13)18/h3-9H,1-2H3,(H,21,22,24)	HGDJUJKASVUOHN-UHFFFAOYSA-N	508347	US11130759, Cpd. No. 658::US11046691, Compound 658::1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 658	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508347	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508347&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147772151	459093422							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072202	CCc1ccc2c(NC)nc(=O)n(-c3ncccc3Cl)c2c1 |(-4.05,-1.95,;-4.05,-.41,;-2.72,.36,;-2.67,1.93,;-1.33,2.69,;,1.92,;1.33,2.69,;1.33,4.23,;,5,;2.67,1.92,;2.67,.38,;4,-.38,;1.33,-.39,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.92,;,.38,;-1.33,-.38,)|	InChI=1S/C16H15ClN4O/c1-3-10-6-7-11-13(9-10)21(16(22)20-14(11)18-2)15-12(17)5-4-8-19-15/h4-9H,3H2,1-2H3,(H,18,20,22)	ZBHRTYQAWGMLGI-UHFFFAOYSA-N	508348	US11130759, Cpd. No. 659::US11046691, Compound 659::1-(3-chloropyridin-2-yl)-7-ethyl-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 659	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508348	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508348&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609057	459093423							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072203	CC(F)(F)c1ccc2c(N)nc(=O)n(-c3ncccc3Cl)c2c1 |(-2.74,-1.31,;-3.51,.02,;-4.84,-.75,;-4.28,1.36,;-2.17,.79,;-2.17,2.33,;-.84,3.1,;.5,2.33,;1.83,3.1,;1.83,4.64,;3.16,2.33,;3.16,.79,;4.5,.02,;1.83,.02,;1.83,-1.52,;.5,-2.29,;.5,-3.83,;1.83,-4.6,;3.16,-3.83,;3.16,-2.29,;4.5,-1.52,;.5,.79,;-.84,.02,)|	InChI=1S/C15H11ClF2N4O/c1-15(17,18)8-4-5-9-11(7-8)22(14(23)21-12(9)19)13-10(16)3-2-6-20-13/h2-7H,1H3,(H2,19,21,23)	KJBMJBPOHAQRBM-UHFFFAOYSA-N	508349	US11130759, Cpd. No. 660::US11046691, Compound 660::4-amino-1-(3-chloropyridin-2-yl)-7- (1,1-difluoroethyl)quinazolin-2(1H)-one::US11084798, Cpd No 660	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508349&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608543	459093424							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072204	CNc1nc(=O)n(-c2ncccc2Cl)c2cc(ccc12)C(C)(F)F |(.62,5.03,;1.95,4.26,;1.95,2.72,;3.29,1.95,;3.29,.41,;4.62,-.36,;1.95,-.36,;1.95,-1.9,;.62,-2.67,;.62,-4.21,;1.95,-4.98,;3.29,-4.21,;3.29,-2.67,;4.62,-1.9,;.62,.41,;-.72,-.36,;-2.05,.41,;-2.05,1.95,;-.72,2.72,;.62,1.95,;-3.38,-.36,;-2.61,-1.7,;-4.72,-1.13,;-4.15,.97,)|	InChI=1S/C16H13ClF2N4O/c1-16(18,19)9-5-6-10-12(8-9)23(15(24)22-13(10)20-2)14-11(17)4-3-7-21-14/h3-8H,1-2H3,(H,20,22,24)	JBBVYFAUELHRPJ-UHFFFAOYSA-N	508350	US11130759, Cpd. No. 661::US11046691, Compound 661::1-(3-chloropyridin-2-yl)-7-(1,1- difluoroethyl)-4-(methylamino)- quinazolin-2(1H)-one::US11084798, Cpd No 661	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508350	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508350&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608767	459093425							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072205	CC(F)(F)c1ccc2c(N)nc(=O)n(-c3ccn4ccnc4c3)c2c1	InChI=1S/C17H13F2N5O/c1-17(18,19)10-2-3-12-13(8-10)24(16(25)22-15(12)20)11-4-6-23-7-5-21-14(23)9-11/h2-9H,1H3,(H2,20,22,25)	VSWWODKWXBUFET-UHFFFAOYSA-N	508351	US11130759, Cpd. No. 662::US11046691, Compound 662::4-amino-7-(1,1-difluoroethyl)-1- (imidazo[1,2-a]pyridin-7-yl)quinazolin- 2(1H)-one::US11084798, Cpd No 662	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508351&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608970	459093426							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072206	CNc1nc(=O)n(-c2ccn3ccnc3c2)c2cc(ccc12)C(C)(F)F	InChI=1S/C18H15F2N5O/c1-18(19,20)11-3-4-13-14(9-11)25(17(26)23-16(13)21-2)12-5-7-24-8-6-22-15(24)10-12/h3-10H,1-2H3,(H,21,23,26)	HKMNUXOFOOAQCI-UHFFFAOYSA-N	508352	US11130759, Cpd. No. 663::US11046691, Compound 663::7-(1,1-difluoroethyl)-1-(imidazo[1,2- a]pyridin-7-yl)-4-(methylamino)- quinazolin-2(1H)-one::US11084798, Cpd No 663	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508352	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508352&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608780	459093427							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072207	COc1cc2c(NCC3CC3)nc(=O)n(-c3ccccc3Cl)c2cc1C1CC1 |(-3.73,4.21,;-4,2.7,;-2.67,1.93,;-1.33,2.69,;,1.93,;1.33,2.69,;1.33,4.23,;2.67,5,;4,4.23,;4.77,2.9,;5.54,4.23,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.92,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-5.54,-.38,;-4.77,-1.72,)|	InChI=1S/C22H22ClN3O2/c1-28-20-11-16-19(10-15(20)14-8-9-14)26(18-5-3-2-4-17(18)23)22(27)25-21(16)24-12-13-6-7-13/h2-5,10-11,13-14H,6-9,12H2,1H3,(H,24,25,27)	XSGLNKJCTURSBH-UHFFFAOYSA-N	508353	US11130759, Cpd. No. 664::US11046691, Compound 664::1-(2-chlorophenyl)-7-cyclopropyl-4- ((cyclopropylmethyl)amino)-6- methoxyquinazolin-2(1H)-one::US11084798, Cpd No 664	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508353	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508353&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608380	459093428							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072208	F[C@@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(Br)cc12 |r,wU:3.4,1.0,(5.54,3.57,;4.21,4.34,;3.44,5.67,;2.67,4.34,;1.33,3.57,;1.33,2.03,;2.67,1.26,;2.67,-.28,;4,-1.05,;1.33,-1.05,;1.33,-2.59,;2.67,-3.36,;2.67,-4.9,;1.33,-5.67,;,-4.9,;,-3.36,;-1.33,-2.59,;,-.28,;-1.33,-1.05,;-2.67,-.28,;-4,-1.05,;-5.54,-1.05,;-4.77,-2.39,;-2.67,1.26,;-4,2.03,;-1.33,2.03,;,1.26,)|	InChI=1S/C20H16BrClFN3O/c21-13-7-12-18(8-11(13)10-5-6-10)26(17-4-2-1-3-14(17)22)20(27)25-19(12)24-16-9-15(16)23/h1-4,7-8,10,15-16H,5-6,9H2,(H,24,25,27)	XRWRBUQUIOTCPB-UHFFFAOYSA-N	508354	US11130759, Cpd. No. 665::US11046691, Compound 665::6-bromo-1-(2-chlorophenyl)-7- cyclopropyl-4-(((1S,2R)-2-fluorocyclo- propyl)amino)quinazolin-2(1H)-one::US11084798, Cpd No 665	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508354	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508354&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152443085	459093429							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072209	F[C@@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(cc12)C#N |r,wU:3.4,1.0,(5.54,3.57,;4.21,4.34,;3.44,5.67,;2.67,4.34,;1.33,3.57,;1.33,2.03,;2.67,1.26,;2.67,-.28,;4,-1.05,;1.33,-1.05,;1.33,-2.59,;2.67,-3.36,;2.67,-4.9,;1.33,-5.67,;,-4.9,;,-3.36,;-1.33,-2.59,;,-.28,;-1.33,-1.05,;-2.67,-.28,;-4,-1.05,;-5.54,-1.05,;-4.77,-2.39,;-2.67,1.26,;-1.33,2.03,;,1.26,;-4,2.03,;-5.33,2.8,)|	InChI=1S/C21H16ClFN4O/c22-15-3-1-2-4-18(15)27-19-8-13(11-5-6-11)12(10-24)7-14(19)20(26-21(27)28)25-17-9-16(17)23/h1-4,7-8,11,16-17H,5-6,9H2,(H,25,26,28)	OLAOVQCVJTWBCO-UHFFFAOYSA-N	508355	US11130759, Cpd. No. 666::US11046691, Compound 666::1-(2-chlorophenyl)-7-cyclopropyl-4- (((1S,2R)-2-fluorocyclopropyl)amino)- 2-oxo-1,2-dihydroquinazoline-6- carbonitrile::US11084798, Cpd No 666	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508355	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508355&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609051	459093430							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072210	F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(cc12)C#N |r,wU:3.4,wD:1.0,(5.54,3.57,;4.21,4.34,;3.44,5.67,;2.67,4.34,;1.33,3.57,;1.33,2.03,;2.67,1.26,;2.67,-.28,;4,-1.05,;1.33,-1.05,;1.33,-2.59,;2.67,-3.36,;2.67,-4.9,;1.33,-5.67,;,-4.9,;,-3.36,;-1.33,-2.59,;,-.28,;-1.33,-1.05,;-2.67,-.28,;-4,-1.05,;-5.54,-1.05,;-4.77,-2.39,;-2.67,1.26,;-1.33,2.03,;,1.26,;-4,2.03,;-5.33,2.8,)|	InChI=1S/C21H16ClFN4O/c22-15-3-1-2-4-18(15)27-19-8-13(11-5-6-11)12(10-24)7-14(19)20(26-21(27)28)25-17-9-16(17)23/h1-4,7-8,11,16-17H,5-6,9H2,(H,25,26,28)	OLAOVQCVJTWBCO-UHFFFAOYSA-N	508356	US11130759, Cpd. No. 667::US11046691, Compound 667::1-(2-chlorophenyl)-7-cyclopropyl-4- (((trans)-2-fluorocyclopropyl)amino)-2- oxo-1,2-dihydroquinazoline-6- carbonitrile::US11084798, Cpd No 667	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508356&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933560	459093431							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072211	Nc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(cc12)C#N |(2.1,4.62,;2.1,3.08,;3.44,2.31,;3.44,.77,;4.77,,;2.1,,;2.1,-1.54,;3.44,-2.31,;3.44,-3.85,;2.1,-4.62,;.77,-3.85,;.77,-2.31,;-.56,-1.54,;.77,.77,;-.56,,;-1.9,.77,;-3.23,,;-4.77,,;-4,-1.33,;-1.9,2.31,;-.56,3.08,;.77,2.31,;-3.23,3.08,;-4.56,3.85,)|	InChI=1S/C18H13ClN4O/c19-14-3-1-2-4-15(14)23-16-8-12(10-5-6-10)11(9-20)7-13(16)17(21)22-18(23)24/h1-4,7-8,10H,5-6H2,(H2,21,22,24)	RQWQRUZIOGYJNN-UHFFFAOYSA-N	508357	US11130759, Cpd. No. 668::US11046691, Compound 668::4-amino-1-(2-chlorophenyl)-7- cyclopropyl-2-oxo-1,2-dihydro- quinazoline-6-carbonitrile::US11084798, Cpd No 668	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508357	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508357&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608772	459093432							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072212	OCC1(CC1)Nc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(cc12)C#N |(5.44,4.34,;4.1,3.57,;2.77,4.34,;3.54,5.67,;2,5.67,;1.44,3.57,;1.44,2.03,;2.77,1.26,;2.77,-.28,;4.1,-1.05,;1.44,-1.05,;1.44,-2.59,;2.77,-3.36,;2.77,-4.9,;1.44,-5.67,;.1,-4.9,;.1,-3.36,;-1.23,-2.59,;.1,-.28,;-1.23,-1.05,;-2.56,-.28,;-3.9,-1.05,;-5.44,-1.05,;-4.67,-2.39,;-2.56,1.26,;-1.23,2.03,;.1,1.26,;-3.9,2.03,;-5.23,2.8,)|	InChI=1S/C22H19ClN4O2/c23-17-3-1-2-4-18(17)27-19-10-15(13-5-6-13)14(11-24)9-16(19)20(25-21(27)29)26-22(12-28)7-8-22/h1-4,9-10,13,28H,5-8,12H2,(H,25,26,29)	GEFDUEQUSUAZDC-UHFFFAOYSA-N	508358	US11130759, Cpd. No. 669::US11046691, Compound 669::1-(2-chlorophenyl)-7-cyclopropyl-4-((1- (hydroxymethyl)cyclopropyl)amino)-2- oxo-1,2-dihydroquinazoline-6- carbonitrile::US11084798, Cpd No 669	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508358	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508358&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609010	459093433							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072213	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(c(cc12)C#N)C(F)(F)F |(.67,5,;2,4.23,;2,2.69,;3.33,1.92,;3.33,.38,;4.67,-.38,;2,-.39,;2,-1.93,;3.33,-2.69,;3.33,-4.23,;2,-5,;.67,-4.23,;.67,-2.69,;-.67,-1.92,;.67,.38,;-.67,-.38,;-2.04,.37,;-2.04,1.94,;-.67,2.69,;.67,1.92,;-3.37,2.72,;-4.69,3.51,;-3.37,-.41,;-4.69,-1.2,;-2.58,-1.74,;-4.15,.91,)|	InChI=1S/C17H10ClF3N4O/c1-23-15-10-6-9(8-22)11(17(19,20)21)7-14(10)25(16(26)24-15)13-5-3-2-4-12(13)18/h2-7H,1H3,(H,23,24,26)	HVZVNCPVWBTLKD-UHFFFAOYSA-N	508359	US11130759, Cpd. No. 670::US11046691, Compound 670::1-(2-chlorophenyl)-4-(methylamino)-2- oxo-7-(trifluoromethyl)-1,2-dihydro- quinazoline-6-carbonitrile::US11084798, Cpd No 670	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508359	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508359&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608933	459093434							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072214	FC(F)(F)c1cc2n(-c3ccccc3Cl)c(=O)nc(NCC3CC3)c2cc1C#N |(-5.44,-1.16,;-4.1,-.39,;-3.33,-1.72,;-4.87,.95,;-2.77,.38,;-1.44,-.39,;-.1,.38,;1.23,-.38,;1.23,-1.93,;2.56,-2.69,;2.56,-4.23,;1.23,-5,;-.1,-4.23,;-.1,-2.69,;-1.44,-1.92,;2.56,.38,;3.9,-.38,;2.56,1.93,;1.23,2.69,;1.23,4.23,;2.56,5,;3.9,4.24,;4.67,2.9,;5.44,4.24,;-.1,1.92,;-1.44,2.69,;-2.77,1.92,;-4.1,2.69,;-5.44,3.46,)|	InChI=1S/C20H14ClF3N4O/c21-15-3-1-2-4-16(15)28-17-8-14(20(22,23)24)12(9-25)7-13(17)18(27-19(28)29)26-10-11-5-6-11/h1-4,7-8,11H,5-6,10H2,(H,26,27,29)	SCSKQBZQSYDOBG-UHFFFAOYSA-N	508360	US11130759, Cpd. No. 671::US11046691, Compound 671::1-(2-chlorophenyl)-4-((cyclopropyl- methyl)amino)-2-oxo-7-(trifluoro- methyl)-1,2-dihydroquinazoline-6- carbonitrile::US11084798, Cpd No 671	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508360&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608552	459093435							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072215	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(F)cc12 |(.77,5,;2.1,4.23,;2.1,2.69,;3.44,1.92,;3.44,.38,;4.77,-.38,;2.1,-.39,;2.1,-1.93,;3.44,-2.69,;3.44,-4.23,;2.1,-5,;.77,-4.23,;.77,-2.69,;-.56,-1.92,;.77,.38,;-.56,-.38,;-1.9,.38,;-3.23,-.38,;-4,-1.72,;-4.77,-.38,;-1.9,1.93,;-3.23,2.7,;-.56,2.69,;.77,1.92,)|	InChI=1S/C18H15ClFN3O/c1-21-17-12-8-14(20)11(10-6-7-10)9-16(12)23(18(24)22-17)15-5-3-2-4-13(15)19/h2-5,8-10H,6-7H2,1H3,(H,21,22,24)	JRZBPGDSCIYDHA-UHFFFAOYSA-N	508361	US11130759, Cpd. No. 672::US11046691, Compound 672::1-(2-chlorophenyl)-7-cyclopropyl-6- fluoro-4-(methylamino)quinazolin- 2(1H)-one::US11084798, Cpd No 672	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508361&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148114661	459093436							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072216	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(Br)c(F)cc12 |(,5,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.38,;1.33,-.39,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.92,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-2.67,1.93,;-4,2.7,;-1.33,2.69,;,1.92,)|	InChI=1S/C15H10BrClFN3O/c1-19-14-8-6-11(18)9(16)7-13(8)21(15(22)20-14)12-5-3-2-4-10(12)17/h2-7H,1H3,(H,19,20,22)	ZRNWGTYXGNFKMX-UHFFFAOYSA-N	508362	US11130759, Cpd. No. 673::US11046691, Compound 673::7-bromo-1-(2-chlorophenyl)-6-fluoro-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 673	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508362&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608381	459093437							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072217	Fc1cc2c(NCC3CC3)nc(=O)n(-c3ccccc3Cl)c2cc1C1CC1 |(-4,2.7,;-2.67,1.93,;-1.33,2.69,;,1.93,;1.33,2.69,;1.33,4.23,;2.67,5,;4,4.23,;4.77,2.9,;5.54,4.23,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.92,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-4.77,-1.72,;-5.54,-.38,)|	InChI=1S/C21H19ClFN3O/c22-16-3-1-2-4-18(16)26-19-10-14(13-7-8-13)17(23)9-15(19)20(25-21(26)27)24-11-12-5-6-12/h1-4,9-10,12-13H,5-8,11H2,(H,24,25,27)	WFCNWDFBDMECDW-UHFFFAOYSA-N	508363	US11130759, Cpd. No. 674::US11046691, Compound 674::1-(2-chlorophenyl)-7-cyclopropyl-4- ((cyclopropylmethyl)amino)-6-fluoro- quinazolin-2(1H)-one::US11084798, Cpd No 674	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508363	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508363&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608785	459093438							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072218	FC(F)CNc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(cc12)C#N |(5.44,5,;4.1,4.23,;4.1,2.7,;2.77,5,;1.44,4.23,;1.44,2.69,;2.77,1.93,;2.77,.38,;4.1,-.38,;1.44,-.38,;1.44,-1.93,;2.77,-2.69,;2.77,-4.23,;1.44,-5,;.1,-4.23,;.1,-2.69,;-1.23,-1.92,;.1,.38,;-1.23,-.39,;-2.56,.38,;-3.9,-.38,;-4.67,-1.72,;-5.44,-.38,;-2.56,1.92,;-1.23,2.69,;.1,1.92,;-3.9,2.69,;-5.23,3.46,)|	InChI=1S/C20H15ClF2N4O/c21-15-3-1-2-4-16(15)27-17-8-13(11-5-6-11)12(9-24)7-14(17)19(26-20(27)28)25-10-18(22)23/h1-4,7-8,11,18H,5-6,10H2,(H,25,26,28)	UXSJEHZHUVUUML-UHFFFAOYSA-N	508364	US11130759, Cpd. No. 675::US11046691, Compound 675::1-(2-chlorophenyl)-7-cyclopropyl-4- ((2,2-difluoroethyl)amino)-2-oxo-1,2- dihydro-quinazoline-6-carbonitrile::US11084798, Cpd No 675	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508364&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609064	459093439							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072219	CC(F)(F)c1cc2n(-c3ccccc3Cl)c(=O)nc(N[C@H]3C[C@H]3F)c2cc1Br |r,wD:20.20,22.24,(-4.92,.17,;-4.15,-1.16,;-5.49,-1.93,;-3.38,-2.5,;-2.82,-.39,;-1.48,-1.16,;-.15,-.39,;1.18,-1.16,;1.18,-2.7,;-.15,-3.47,;-.15,-5.01,;1.18,-5.78,;2.52,-5.01,;2.52,-3.47,;3.85,-2.7,;2.52,-.39,;3.85,-1.16,;2.52,1.15,;1.18,1.92,;1.18,3.46,;2.52,4.23,;4.06,4.23,;3.29,5.56,;3.29,7.1,;-.15,1.15,;-1.48,1.92,;-2.82,1.15,;-4.15,1.92,)|	InChI=1S/C19H14BrClF3N3O/c1-19(23,24)10-7-16-9(6-11(10)20)17(25-14-8-13(14)22)26-18(28)27(16)15-5-3-2-4-12(15)21/h2-7,13-14H,8H2,1H3,(H,25,26,28)	PKSAXCYUXXECBJ-UHFFFAOYSA-N	508366	US11130759, Cpd. No. 677::US11046691, Compound 677::6-bromo-1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4-(((1S,2R)-2- fluorocyclopropyl)amino)quinazolin- 2(1H)-one::US11084798, Cpd No 676	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508366&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609056	459093441							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072220	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(c(Br)cc12)C(C)(F)F |(.62,5.03,;1.96,4.26,;1.96,2.72,;3.29,1.95,;3.29,.41,;4.63,-.36,;1.96,-.36,;1.96,-1.9,;.62,-2.67,;.62,-4.21,;1.96,-4.98,;3.29,-4.21,;3.29,-2.67,;4.63,-1.9,;.62,.41,;-.71,-.36,;-2.04,.41,;-2.04,1.95,;-3.38,2.72,;-.71,2.72,;.62,1.95,;-3.38,-.36,;-4.15,.97,;-4.71,-1.13,;-2.61,-1.7,)|	InChI=1S/C17H13BrClF2N3O/c1-17(20,21)10-8-14-9(7-11(10)18)15(22-2)23-16(25)24(14)13-6-4-3-5-12(13)19/h3-8H,1-2H3,(H,22,23,25)	YQYGLLMEUIMYIJ-UHFFFAOYSA-N	508365	US11130759, Cpd. No. 676::US11046691, Compound 676::6-bromo-1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4-(methylamino)- quinazolin-2(1H)-one::US11084798, Cpd No 677	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508365&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608233	459093440							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072221	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(c(cc12)C#N)C(C)(F)F |(.68,5.06,;2.01,4.29,;2.01,2.75,;3.35,1.98,;3.35,.44,;4.68,-.33,;2.01,-.33,;2.01,-1.87,;.68,-2.64,;.68,-4.18,;2.01,-4.95,;3.35,-4.18,;3.35,-2.64,;4.68,-1.87,;.68,.44,;-.65,-.33,;-1.99,.44,;-1.99,1.98,;-.65,2.75,;.68,1.98,;-3.32,2.75,;-4.65,3.52,;-3.32,-.33,;-4.09,1,;-4.65,-1.1,;-2.55,-1.67,)|	InChI=1S/C18H13ClF2N4O/c1-18(20,21)12-8-15-11(7-10(12)9-22)16(23-2)24-17(26)25(15)14-6-4-3-5-13(14)19/h3-8H,1-2H3,(H,23,24,26)	IRVOMXJTFPHILJ-UHFFFAOYSA-N	508367	US11130759, Cpd. No. 678::US11046691, Compound 678::1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4-(methylamino)-2-oxo- 1,2-dihydro-quinazoline-6-carbonitrile::US11084798, Cpd No 678	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508367&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608457	459093442							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072222	CC(F)(F)c1cc2n(-c3ccccc3Cl)c(=O)nc(NCC3CC3)c2cc1C#N |(-4.36,.62,;-3.59,-.72,;-4.92,-1.49,;-2.82,-2.05,;-2.25,.05,;-.92,-.72,;.41,.05,;1.75,-.72,;1.75,-2.26,;.41,-3.03,;.41,-4.57,;1.75,-5.34,;3.08,-4.57,;3.08,-3.03,;4.41,-2.26,;3.08,.05,;4.41,-.72,;3.08,1.59,;1.75,2.36,;1.75,3.9,;.41,4.67,;.41,6.21,;-.36,7.55,;1.18,7.55,;.41,1.59,;-.92,2.36,;-2.25,1.59,;-3.59,2.36,;-4.92,3.13,)|	InChI=1S/C21H17ClF2N4O/c1-21(23,24)15-9-18-14(8-13(15)10-25)19(26-11-12-6-7-12)27-20(29)28(18)17-5-3-2-4-16(17)22/h2-5,8-9,12H,6-7,11H2,1H3,(H,26,27,29)	BQEWIHHVZWYYGO-UHFFFAOYSA-N	508368	US11130759, Cpd. No. 679::US11046691, Compound 679::1-(2-chlorophenyl)-4-((cyclopropyl- methyl)amino)-7-(1,1-difluoroethyl)-2- oxo-1,2-dihydroquinazoline-6- carbonitrile::US11084798, Cpd No 679	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508368&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608807	459093443							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072223	CNc1nc(=O)n(-c2ccccc2C)c2cc(C3CC3)c(cc12)C#N |(.77,5,;2.1,4.23,;2.1,2.69,;3.44,1.92,;3.44,.38,;4.77,-.38,;2.1,-.39,;2.1,-1.93,;3.44,-2.69,;3.44,-4.23,;2.1,-5,;.77,-4.23,;.72,-2.67,;-.61,-1.9,;.77,.38,;-.56,-.38,;-1.9,.38,;-3.23,-.38,;-4.77,-.38,;-4,-1.72,;-1.95,1.95,;-.56,2.69,;.77,1.92,;-3.28,2.72,;-4.61,3.49,)|	InChI=1S/C20H18N4O/c1-12-5-3-4-6-17(12)24-18-10-15(13-7-8-13)14(11-21)9-16(18)19(22-2)23-20(24)25/h3-6,9-10,13H,7-8H2,1-2H3,(H,22,23,25)	YOOUNIDXAQRTFH-UHFFFAOYSA-N	508369	US11130759, Cpd. No. 680::US11046691, Compound 680::7-cyclopropyl-4-(methylamino)-2-oxo- 1-(o-tolyl)-1,2-dihydroquinazoline-6- carbonitrile::US11084798, Cpd No 680	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508369&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149396669	459093444							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072224	Cc1ccccc1-n1c2cc(C3CC3)c(cc2c(NCC2CC2)nc1=O)C#N |(-1.38,-1.9,;-.05,-2.67,;,-4.23,;1.33,-5,;2.67,-4.23,;2.67,-2.69,;1.33,-1.93,;1.33,-.38,;,.38,;-1.33,-.39,;-2.67,.38,;-4,-.38,;-5.54,-.38,;-4.77,-1.72,;-2.67,1.92,;-1.33,2.69,;,1.92,;1.33,2.69,;1.33,4.23,;2.67,5,;4,4.23,;4.77,2.9,;5.54,4.23,;2.67,1.93,;2.67,.38,;4,-.38,;-4,2.69,;-5.33,3.46,)|	InChI=1S/C23H22N4O/c1-14-4-2-3-5-20(14)27-21-11-18(16-8-9-16)17(12-24)10-19(21)22(26-23(27)28)25-13-15-6-7-15/h2-5,10-11,15-16H,6-9,13H2,1H3,(H,25,26,28)	GKPYWMUOJMLBGT-UHFFFAOYSA-N	508370	US11130759, Cpd. No. 681::US11046691, Compound 681::7-cyclopropyl-4-((cyclopropylmethyl)- amino)-2-oxo-1-(o-tolyl)-1,2-dihydro- quinazoline-6-carbonitrile::US11084798, Cpd No 681	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508370&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608673	459093445							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072225	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(SC)cc12 |(.77,5,;2.1,4.23,;2.1,2.69,;3.44,1.92,;3.44,.38,;4.77,-.38,;2.1,-.39,;2.1,-1.93,;3.44,-2.69,;3.44,-4.23,;2.1,-5,;.77,-4.23,;.77,-2.69,;-.56,-1.92,;.77,.38,;-.56,-.38,;-1.9,.38,;-3.23,-.38,;-4.77,-.38,;-4,-1.72,;-1.9,1.93,;-3.23,2.7,;-3.63,4.18,;-.56,2.69,;.77,1.92,)|	InChI=1S/C19H18ClN3OS/c1-21-18-13-10-17(25-2)12(11-7-8-11)9-16(13)23(19(24)22-18)15-6-4-3-5-14(15)20/h3-6,9-11H,7-8H2,1-2H3,(H,21,22,24)	YDDWMOXUPZRXHI-UHFFFAOYSA-N	508371	US11130759, Cpd. No. 682::US11046691, Compound 682::1-(2-chlorophenyl)-7-cyclopropyl-4- (methylamino)-6-(methylthio)- quinazolin-2(1H)-one::US11084798, Cpd No 682	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508371&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608926	459093446							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072226	CSc1cc2c(NCC3CC3)nc(=O)n(-c3ccccc3Cl)c2cc1C1CC1 |(-4.4,4.18,;-4,2.7,;-2.67,1.93,;-1.33,2.69,;,1.93,;1.33,2.69,;1.33,4.23,;2.67,5,;4,4.23,;4.77,2.9,;5.54,4.23,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.92,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-5.54,-.38,;-4.77,-1.72,)|	InChI=1S/C22H22ClN3OS/c1-28-20-11-16-19(10-15(20)14-8-9-14)26(18-5-3-2-4-17(18)23)22(27)25-21(16)24-12-13-6-7-13/h2-5,10-11,13-14H,6-9,12H2,1H3,(H,24,25,27)	VGCUBKARTRMPCT-UHFFFAOYSA-N	508372	US11130759, Cpd. No. 683::US11046691, Compound 683::1-(2-chlorophenyl)-7-cyclopropyl-4- ((cyclopropylmethyl)amino)-6- (methylthio)quinazolin-2(1H)-one::US11084798, Cpd No 683	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508372&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609019	459093447							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072227	FC(F)(F)c1cc2n(-c3ccccc3)c(=O)nc(NCC3CC3)c2cc1Br	InChI=1S/C19H15BrF3N3O/c20-15-8-13-16(9-14(15)19(21,22)23)26(12-4-2-1-3-5-12)18(27)25-17(13)24-10-11-6-7-11/h1-5,8-9,11H,6-7,10H2,(H,24,25,27)	JIFZHQCDUDLKQP-UHFFFAOYSA-N	508373	US11130759, Cpd. No. 684::US11046691, Compound 684::6-bromo-4- ((cyclopropylmethyl)amino)-1-phenyl- 7-(trifluoromethyl)quinazolin-2(1H)- one::US11084798, Cpd No 684	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508373&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148061082	459093448							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072228	CN(CC1CC1)c1nc(=O)n(-c2ccccc2)c2cc(c(Br)cc12)C(F)(F)F	InChI=1S/C20H17BrF3N3O/c1-26(11-12-7-8-12)18-14-9-16(21)15(20(22,23)24)10-17(14)27(19(28)25-18)13-5-3-2-4-6-13/h2-6,9-10,12H,7-8,11H2,1H3	ZZEJQRDGXMTFJN-UHFFFAOYSA-N	508374	US11130759, Cpd. No. 685::US11046691, Compound 685::6-bromo-4-((cyclopropylmethyl)- (methyl)amino)-1-phenyl-7- (trifluoromethyl)-quinazolin-2(1H)-one::US11084798, Cpd No 685	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508374&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149598026	459093449							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072229	Clc1ccccc1-n1c2nc(C3CC3)c(cc2c(NCC2CC2)nc1=O)C#N |(-1.33,-1.92,;,-2.69,;,-4.23,;1.33,-5,;2.67,-4.23,;2.67,-2.69,;1.33,-1.93,;1.33,-.38,;,.38,;-1.33,-.39,;-2.67,.38,;-4,-.38,;-5.54,-.38,;-4.77,-1.72,;-2.67,1.92,;-1.33,2.69,;,1.92,;1.33,2.69,;1.33,4.23,;2.67,5,;4,4.23,;4.77,2.9,;5.54,4.23,;2.67,1.93,;2.67,.38,;4,-.38,;-4,2.69,;-5.33,3.46,)|	InChI=1S/C21H18ClN5O/c22-16-3-1-2-4-17(16)27-20-15(9-14(10-23)18(25-20)13-7-8-13)19(26-21(27)28)24-11-12-5-6-12/h1-4,9,12-13H,5-8,11H2,(H,24,26,28)	HANWODPABRKWKO-UHFFFAOYSA-N	508375	US11130759, Cpd. No. 686::US11046691, Compound 686::1-(2-chlorophenyl)-7-cyclopropyl-4- ((cyclopropylmethyl)amino)-2-oxo-1,2- dihydropyrido[2,3-d]pyrimidine-6- carbonitrile::US11084798, Cpd No 686	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508375&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609046	459093450							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072230	F[C@@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2nc(C3CC3)c(cc12)C#N |r,wU:3.4,1.0,(5.54,3.57,;4.21,4.34,;3.44,5.67,;2.67,4.34,;1.33,3.57,;1.33,2.03,;2.67,1.26,;2.67,-.28,;4,-1.05,;1.33,-1.05,;1.33,-2.59,;2.67,-3.36,;2.67,-4.9,;1.33,-5.67,;,-4.9,;,-3.36,;-1.33,-2.59,;,-.28,;-1.33,-1.05,;-2.67,-.28,;-4,-1.05,;-5.54,-1.05,;-4.77,-2.39,;-2.67,1.26,;-1.33,2.03,;,1.26,;-4,2.03,;-5.33,2.8,)|	InChI=1S/C20H15ClFN5O/c21-13-3-1-2-4-16(13)27-19-12(7-11(9-23)17(25-19)10-5-6-10)18(26-20(27)28)24-15-8-14(15)22/h1-4,7,10,14-15H,5-6,8H2,(H,24,26,28)	VQQSRXBFBLPZSK-UHFFFAOYSA-N	508376	US11130759, Cpd. No. 687::US11046691, Compound 687::1-(2-chlorophenyl)-7-cyclopropyl-4- (((lS,2R)-2-fluorocyclopropyl)amino)- 2-oxo-1,2-dihydropyrido[2,3-d]- pyrimidine-6-carbonitrile::US11084798, Cpd No 687	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508376&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608572	459093451							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072231	COc1cc(Cl)cc2n(-c3ccccc3C)c(=O)nc(NCC(F)F)c12 |(-1.07,5.37,;-1.33,3.85,;,3.08,;1.33,3.85,;2.67,3.08,;4,3.85,;2.67,1.54,;1.33,.77,;1.33,-.77,;2.67,-1.54,;2.67,-3.08,;4,-3.85,;5.33,-3.08,;5.33,-1.54,;4,-.71,;4,.83,;,-1.54,;,-3.08,;-1.33,-.77,;-1.33,.77,;-2.67,1.54,;-4,.77,;-5.33,1.54,;-5.33,3.08,;-6.67,.77,;,1.54,)|	InChI=1S/C18H16ClF2N3O2/c1-10-5-3-4-6-12(10)24-13-7-11(19)8-14(26-2)16(13)17(23-18(24)25)22-9-15(20)21/h3-8,15H,9H2,1-2H3,(H,22,23,25)	UFJUWHXYMHSHBO-UHFFFAOYSA-N	508377	US11130759, Cpd. No. 688::US11046691, Compound 688::7-chloro-4-((2,2-difluoroethyl)amino)- 5-methoxy-1-(o-tolyl)quinazolin-2(1H)- one::US11084798, Cpd No 688	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508377&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151994556	459093452							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072232	CO[C@H]1CC(C1)Nc1nc(=O)n(-c2ccccc2C)c2cc(Cl)cc(OC)c12 |r,wU:2.1,(-7.46,-.1,;-6.28,-1.09,;-4.94,-.32,;-4.55,1.17,;-3.06,.77,;-3.46,-.72,;-1.72,1.54,;-.39,.77,;-.39,-.77,;.94,-1.54,;.94,-3.08,;2.28,-.77,;3.61,-1.54,;3.61,-3.08,;4.94,-3.85,;6.28,-3.08,;6.28,-1.54,;4.94,-.71,;4.94,.83,;2.28,.77,;3.61,1.54,;3.61,3.08,;4.94,3.85,;2.28,3.85,;.94,3.08,;-.39,3.85,;-.12,5.37,;.94,1.54,)|	InChI=1S/C21H22ClN3O3/c1-12-6-4-5-7-16(12)25-17-8-13(22)9-18(28-3)19(17)20(24-21(25)26)23-14-10-15(11-14)27-2/h4-9,14-15H,10-11H2,1-3H3,(H,23,24,26)	BEQFILSMQQQBCO-UHFFFAOYSA-N	508378	US11130759, Cpd. No. 689::US11046691, Compound 689::7-chloro-5-fluoro-4-(((1r,3r)-3- methoxy-cyclobutyl)amino)-1-(o- tolyl)quinazolin-2(1H)-one::US11084798, Cpd No 689	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508378&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149757989	459093453							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072233	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(Cl)cc(OC)c12 |(-5.33,.77,;-4,1.54,;-2.67,.77,;-2.67,-.77,;-1.33,-1.54,;-1.33,-3.08,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;4,-3.08,;4,-1.54,;2.67,-.77,;2.67,.77,;,.77,;1.33,1.54,;1.33,3.08,;2.67,3.85,;,3.85,;-1.33,3.08,;-2.67,3.85,;-2.4,5.37,;-1.33,1.54,)|	InChI=1S/C16H13Cl2N3O2/c1-19-15-14-12(7-9(17)8-13(14)23-2)21(16(22)20-15)11-6-4-3-5-10(11)18/h3-8H,1-2H3,(H,19,20,22)	BGMJXIMDYMAWDD-UHFFFAOYSA-N	508379	US11130759, Cpd. No. 690::US11046691, Compound 690::7-chloro-1-(2-chlorophenyl)-5- methoxy-4-(methylamino)quinazolin- 2(1H)-one::US11084798, Cpd No 690	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508379&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149767342	459093454							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072234	CNc1nc(=O)n(-c2ccccc2C)c2cc(cc(OC)c12)C(F)(F)F |(-5.33,.1,;-4,.87,;-2.67,.1,;-2.67,-1.44,;-1.33,-2.21,;-1.33,-3.75,;,-1.44,;1.33,-2.21,;1.33,-3.75,;2.67,-4.52,;4,-3.75,;4,-2.21,;2.67,-1.38,;2.67,.16,;,.1,;1.33,.87,;1.33,2.41,;,3.18,;-1.33,2.41,;-2.67,3.18,;-2.4,4.7,;-1.33,.87,;2.67,3.18,;4,3.95,;3.44,1.85,;1.9,4.52,)|	InChI=1S/C18H16F3N3O2/c1-10-6-4-5-7-12(10)24-13-8-11(18(19,20)21)9-14(26-3)15(13)16(22-2)23-17(24)25/h4-9H,1-3H3,(H,22,23,25)	HIGVZRBHXKRHER-UHFFFAOYSA-N	508380	US11130759, Cpd. No. 691::US11046691, Compound 691::5-methoxy-4-(methylamino)-1-(o- tolyl)-7-(trifluoromethyl)quinazolin- 2(1H)-one::US11084798, Cpd No 691	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508380&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150423440	459093455							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072235	CNc1nc(=O)n(-c2ccccc2)c2nc(cc(OC)c12)C(F)(F)F	InChI=1S/C16H13F3N4O2/c1-20-13-12-10(25-2)8-11(16(17,18)19)21-14(12)23(15(24)22-13)9-6-4-3-5-7-9/h3-8H,1-2H3,(H,20,22,24)	HBFRAOQJFPKQBG-UHFFFAOYSA-N	508381	US11130759, Cpd. No. 692::US11046691, Compound 692::5-methoxy-4-(methylamino)-1-phenyl- 7-(trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 692	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508381&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150388632	459093456							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072236	CNc1nc(=O)n(-c2c(F)cccc2Cl)c2nc(ccc12)C(F)(F)F |(-5.33,.1,;-4,.87,;-2.67,.1,;-2.67,-1.44,;-1.33,-2.21,;-1.33,-3.75,;,-1.44,;1.33,-2.21,;1.33,-3.75,;,-4.52,;2.67,-4.52,;4,-3.75,;4,-2.21,;2.67,-1.44,;2.67,.1,;,.1,;1.33,.87,;1.33,2.41,;,3.18,;-1.33,2.41,;-1.33,.87,;2.67,3.18,;4,3.95,;3.44,1.85,;1.9,4.52,)|	InChI=1S/C15H9ClF4N4O/c1-21-12-7-5-6-10(15(18,19)20)22-13(7)24(14(25)23-12)11-8(16)3-2-4-9(11)17/h2-6H,1H3,(H,21,23,25)	HMXPRDLGXIASOB-UHFFFAOYSA-N	508382	US11130759, Cpd. No. 693::US11046691, Compound 693::1-(2-chloro-6-fluorophenyl)-4- (methylamino)-7- (trifluoromethyl)pyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 693	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508382&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147808625	459093457							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072237	CNc1nc(=O)n(-c2cccnc2C)c2cc(ccc12)C1CC1 |(-3.44,2.41,;-3.44,.87,;-2.1,.1,;-2.1,-1.44,;-.77,-2.21,;-.77,-3.75,;.56,-1.44,;1.9,-2.21,;1.9,-3.75,;3.23,-4.52,;4.56,-3.75,;4.56,-2.21,;3.23,-1.44,;3.23,.1,;.56,.1,;1.9,.87,;1.9,2.41,;.56,3.18,;-.77,2.41,;-.77,.87,;3.23,3.18,;4.77,3.18,;4,4.52,)|	InChI=1S/C18H18N4O/c1-11-15(4-3-9-20-11)22-16-10-13(12-5-6-12)7-8-14(16)17(19-2)21-18(22)23/h3-4,7-10,12H,5-6H2,1-2H3,(H,19,21,23)	DFJNZBUXAMDBGQ-UHFFFAOYSA-N	508383	US11130759, Cpd. No. 694::US11046691, Compound 694::7-cyclopropyl-4-(methylamino)-1-(2- methylpyridin-3-yl)quinazolin-2(1H) one::US11084798, Cpd No 694	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508383&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150021678	459093458							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072238	C[C@@]1(O)CCN(C1)c1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.1,wD:1.0,(-3.89,4.21,;-4.29,2.72,;-5.38,3.81,;-5.06,1.39,;-4.03,.25,;-2.62,.87,;-2.78,2.4,;-1.29,.1,;-1.29,-1.44,;.04,-2.21,;.04,-3.75,;1.38,-1.44,;2.71,-2.21,;2.71,-3.75,;4.05,-4.52,;5.38,-3.75,;5.38,-2.21,;4.05,-1.44,;4.05,.1,;1.38,.1,;2.71,.87,;2.71,2.41,;1.38,3.18,;.04,2.41,;.04,.87,;4.05,3.18,;5.38,3.95,;3.28,4.52,;4.82,1.85,)|	InChI=1S/C19H16ClF3N4O2/c1-18(29)8-9-26(10-18)15-11-6-7-14(19(21,22)23)24-16(11)27(17(28)25-15)13-5-3-2-4-12(13)20/h2-7,29H,8-10H2,1H3	XUWCMWXRZYJTHC-UHFFFAOYSA-N	508384	US11130759, Cpd. No. 695::US11046691, Compound 695::1-(2-chlorophenyl)-4-(3-hydroxy-3- methylpyrrolidin-1-yl)-7-(trifluoro- methyl) pyrido[2,3-d]pyrimidin-2(1H)- one, single unknown enantiomer::US11084798, Cpd No 695	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508384&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608586	459093459							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072239	CNc1nc(=O)n(Cc2ccccc2)c2nc(ccc12)C(F)(F)F	InChI=1S/C16H13F3N4O/c1-20-13-11-7-8-12(16(17,18)19)21-14(11)23(15(24)22-13)9-10-5-3-2-4-6-10/h2-8H,9H2,1H3,(H,20,22,24)	NACUUNXKFDPKFE-UHFFFAOYSA-N	508385	US11130759, Cpd. No. 696::US11046691, Compound 696::1-benzyl-4-(methylamino)-7-(trifluoro- methyl)pyrido[2,3-d]pyrimidin-2(1H)- one::US11084798, Cpd No 696	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508385&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608883	459093460							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072240	O[C@@H]1CC[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:4.5,wD:1.0,(-5.13,2.53,;-4.36,3.86,;-4.76,5.35,;-3.27,5.75,;-2.87,4.26,;-1.54,3.49,;-1.54,1.95,;-2.87,1.18,;-2.87,-.36,;-4.21,-1.13,;-1.54,-1.13,;-1.54,-2.67,;-.2,-3.44,;-.2,-4.98,;-1.54,-5.75,;-2.87,-4.98,;-2.87,-3.44,;-4.21,-2.67,;-.2,-.36,;1.13,-1.13,;2.52,-.39,;2.46,1.18,;1.13,1.95,;-.2,1.18,;3.85,-1.15,;5.19,-1.92,;3.08,-2.49,;4.62,.18,)|	InChI=1S/C18H14ClF3N4O2/c19-10-3-1-2-4-12(10)26-16-9(5-8-14(24-16)18(20,21)22)15(25-17(26)28)23-11-6-7-13(11)27/h1-5,8,11,13,27H,6-7H2,(H,23,25,28)	SXNFVUHCVCEJLS-UHFFFAOYSA-N	508386	US11130759, Cpd. No. 698::US11046691, Compound 698::1-(2-chlorophenyl)-4-(((trans)-2- hydroxycyclobutyl)amino)-7-(trifluoro- methyl)-pyrido[2,3-d]pyrimidin-2(1H)- one, single unknown enantiomer/ atropisomer::US11046691, Compound 697::US11084798, Cpd No 698	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508386&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154929293	459093461							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072241	O[C@@H]1CC[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:4.5,wD:1.0,(-5.13,2.53,;-4.36,3.86,;-4.76,5.35,;-3.27,5.75,;-2.87,4.26,;-1.54,3.49,;-1.54,1.95,;-2.87,1.18,;-2.87,-.36,;-4.21,-1.13,;-1.54,-1.13,;-1.54,-2.67,;-.2,-3.44,;-.2,-4.98,;-1.54,-5.75,;-2.87,-4.98,;-2.87,-3.44,;-4.21,-2.67,;-.2,-.36,;1.13,-1.13,;2.52,-.39,;2.46,1.18,;1.13,1.95,;-.2,1.18,;3.85,-1.15,;5.19,-1.92,;3.08,-2.49,;4.62,.18,)|	InChI=1S/C18H14ClF3N4O2/c19-10-3-1-2-4-12(10)26-16-9(5-8-14(24-16)18(20,21)22)15(25-17(26)28)23-11-6-7-13(11)27/h1-5,8,11,13,27H,6-7H2,(H,23,25,28)	SXNFVUHCVCEJLS-UHFFFAOYSA-N	508386	US11130759, Cpd. No. 698::US11046691, Compound 698::1-(2-chlorophenyl)-4-(((trans)-2- hydroxycyclobutyl)amino)-7-(trifluoro- methyl)-pyrido[2,3-d]pyrimidin-2(1H)- one, single unknown enantiomer/ atropisomer::US11046691, Compound 697::US11084798, Cpd No 698	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508386&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154929293	459093461							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072242	Nc1nc(=O)n(-c2ccccc2Br)c2cc(ccc12)C1CC1 |(-2.1,4.62,;-2.1,3.08,;-3.44,2.31,;-3.44,.77,;-4.77,,;-2.1,,;-2.1,-1.54,;-3.44,-2.31,;-3.44,-3.85,;-2.1,-4.62,;-.77,-3.85,;-.77,-2.31,;.56,-1.54,;-.77,.77,;.56,,;1.9,.77,;1.9,2.31,;.56,3.08,;-.77,2.31,;3.23,,;4,-1.33,;4.77,,)|	InChI=1S/C17H14BrN3O/c18-13-3-1-2-4-14(13)21-15-9-11(10-5-6-10)7-8-12(15)16(19)20-17(21)22/h1-4,7-10H,5-6H2,(H2,19,20,22)	BONGAWOBRJSHPL-UHFFFAOYSA-N	508388	US11130759, Cpd. No. 699::US11046691, Compound 699::4-amino-1-(2-bromophenyl)-7- cyclopropylquinazolin-2(1H)-one::US11084798, Cpd No 699	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508388	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508388&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149807649	459093462							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072243	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(cc(OC)c12)C1CC1 |(-5.44,.1,;-4.1,.87,;-2.77,.1,;-2.77,-1.44,;-1.44,-2.21,;-1.44,-3.75,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-4.52,;3.9,-3.75,;3.9,-2.21,;2.56,-1.44,;2.56,.1,;-.1,.1,;1.23,.87,;1.23,2.41,;-.1,3.18,;-1.44,2.41,;-2.77,3.18,;-2.5,4.7,;-1.44,.87,;2.56,3.18,;4.1,3.18,;3.33,4.52,)|	InChI=1S/C19H18ClN3O2/c1-21-18-17-15(9-12(11-7-8-11)10-16(17)25-2)23(19(24)22-18)14-6-4-3-5-13(14)20/h3-6,9-11H,7-8H2,1-2H3,(H,21,22,24)	XCGOWVGDXFRUHL-UHFFFAOYSA-N	508389	US11130759, Cpd. No. 700::US11046691, Compound 700::1-(2-chlorophenyl)-7-cyclopropyl-5- methoxy-(methylamino)quinazolin- 2(1H)-one::US11084798, Cpd No 700	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508389&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608932	459093463							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072244	COc1cc(cc2n(-c3ccccc3Cl)c(=O)nc(N)c12)C1CC1 |(-2.5,4.7,;-2.77,3.18,;-1.44,2.41,;-.1,3.18,;1.23,2.41,;1.23,.87,;-.1,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-4.52,;3.9,-3.75,;3.9,-2.21,;2.56,-1.44,;2.56,.1,;-1.44,-2.21,;-1.44,-3.75,;-2.77,-1.44,;-2.77,.1,;-4.1,.87,;-1.44,.87,;2.56,3.18,;4.1,3.18,;3.33,4.52,)|	InChI=1S/C18H16ClN3O2/c1-24-15-9-11(10-6-7-10)8-14-16(15)17(20)21-18(23)22(14)13-5-3-2-4-12(13)19/h2-5,8-10H,6-7H2,1H3,(H2,20,21,23)	YKJKDXXSSVQHPV-UHFFFAOYSA-N	508390	US11130759, Cpd. No. 701::US11046691, Compound 701::4-amino-1-(2-chlorophenyl)-7- cyclopropyl-5-methoxyquinazolin- 2(1H)-one::US11084798, Cpd No 701	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508390&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152535182	459093464							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072245	CNc1nc(=O)n(-c2ccccc2C)c2cc(cc(OC)c12)C1CC1 |(-5.44,.1,;-4.1,.87,;-2.77,.1,;-2.77,-1.44,;-1.44,-2.21,;-1.44,-3.75,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-4.52,;3.9,-3.75,;3.9,-2.21,;2.56,-1.38,;2.56,.16,;-.1,.1,;1.23,.87,;1.23,2.41,;-.1,3.18,;-1.44,2.41,;-2.77,3.18,;-2.5,4.7,;-1.44,.87,;2.56,3.18,;4.1,3.18,;3.33,4.52,)|	InChI=1S/C20H21N3O2/c1-12-6-4-5-7-15(12)23-16-10-14(13-8-9-13)11-17(25-3)18(16)19(21-2)22-20(23)24/h4-7,10-11,13H,8-9H2,1-3H3,(H,21,22,24)	RTBXZMNQFRFPJG-UHFFFAOYSA-N	508391	US11130759, Cpd. No. 702::US11046691, Compound 702::7-cyclopropyl-5-methoxy-4- (methylamino)-1-(o-tolyl)quinazolin- 2(1H)-one::US11084798, Cpd No 702	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508391&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151773527	459093465							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072246	COc1cc(cc2n(-c3ccccc3C)c(=O)nc(N)c12)C1CC1 |(-2.5,4.7,;-2.77,3.18,;-1.44,2.41,;-.1,3.18,;1.23,2.41,;1.23,.87,;-.1,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-4.52,;3.9,-3.75,;3.9,-2.21,;2.56,-1.38,;2.56,.16,;-1.44,-2.21,;-1.44,-3.75,;-2.77,-1.44,;-2.77,.1,;-4.1,.87,;-1.44,.87,;2.56,3.18,;4.1,3.18,;3.33,4.52,)|	InChI=1S/C19H19N3O2/c1-11-5-3-4-6-14(11)22-15-9-13(12-7-8-12)10-16(24-2)17(15)18(20)21-19(22)23/h3-6,9-10,12H,7-8H2,1-2H3,(H2,20,21,23)	ARCSOQKKAUANDU-UHFFFAOYSA-N	508392	US11130759, Cpd. No. 703::US11046691, Compound 703::4-amino-7-cyclopropyl-5-methoxy-1- (o-tolyl)quinazolin-2(1H)-one::US11084798, Cpd No 703	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508392&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149690847	459093466							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072247	CNc1nc(=O)n(-c2cccnc2)c2cc(cc(OC)c12)C1CC1	InChI=1S/C18H18N4O2/c1-19-17-16-14(8-12(11-5-6-11)9-15(16)24-2)22(18(23)21-17)13-4-3-7-20-10-13/h3-4,7-11H,5-6H2,1-2H3,(H,19,21,23)	HIEQBDZMYQJPGZ-UHFFFAOYSA-N	508393	US11130759, Cpd. No. 704::US11046691, Compound 704::7-cyclopropyl-5-methoxy-4-(methyl- amino)-1-(pyridin-3-yl)quinazolin- 2(1H)-one::US11084798, Cpd No 704	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508393&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150423019	459093467							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072248	COc1cc(cc2n(-c3cccnc3)c(=O)nc(N)c12)C1CC1	InChI=1S/C17H16N4O2/c1-23-14-8-11(10-4-5-10)7-13-15(14)16(18)20-17(22)21(13)12-3-2-6-19-9-12/h2-3,6-10H,4-5H2,1H3,(H2,18,20,22)	VAUZLAZWMBACGH-UHFFFAOYSA-N	508394	US11130759, Cpd. No. 705::US11046691, Compound 705::4-amino-7-cyclopropyl-5-methoxy-1- (pyridin-3-yl)quinazolin-2(1H)-one::US11084798, Cpd No 705	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508394&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152098874	459093468							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072249	Cc1ccccc1-n1c2cc(ccc2c(Nc2ccncc2)nc1=O)C1CC1 |(1.23,-3.08,;-.1,-3.85,;-.1,-5.39,;-1.44,-6.16,;-2.77,-5.39,;-2.77,-3.85,;-1.44,-3.08,;-1.44,-1.54,;-.1,-.77,;1.23,-1.54,;2.56,-.77,;2.56,.77,;1.23,1.54,;-.1,.77,;-1.44,1.54,;-1.44,3.08,;-2.77,3.85,;-2.77,5.39,;-4.1,6.16,;-5.44,5.39,;-5.44,3.85,;-4.1,3.08,;-2.77,.77,;-2.77,-.77,;-4.1,-1.54,;3.9,-1.54,;4.67,-2.87,;5.44,-1.54,)|	InChI=1S/C23H20N4O/c1-15-4-2-3-5-20(15)27-21-14-17(16-6-7-16)8-9-19(21)22(26-23(27)28)25-18-10-12-24-13-11-18/h2-5,8-14,16H,6-7H2,1H3,(H,24,25,26,28)	WXQGFDLLLYXXNS-UHFFFAOYSA-N	508395	US11130759, Cpd. No. 706::US11046691, Compound 706::7-cyclopropyl-4-(pyridin-4-ylamino)-1- (o-tolyl)quinazolin-2(1H)-one::US11084798, Cpd No 706	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508395&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152342085	459093469							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072250	FC(F)(F)c1ccc2c(Nc3cscn3)nc(=O)n(-c3ccccc3Cl)c2n1 |(5.89,3.95,;4.55,3.18,;3.78,4.52,;5.32,1.85,;3.22,2.41,;1.89,3.18,;.55,2.41,;.55,.87,;-.78,.1,;-2.12,.87,;-3.45,.1,;-3.61,-1.43,;-5.12,-1.75,;-5.89,-.41,;-4.86,.73,;-.78,-1.44,;.55,-2.21,;.55,-3.75,;1.89,-1.44,;3.22,-2.21,;3.22,-3.75,;4.55,-4.52,;5.89,-3.75,;5.89,-2.21,;4.55,-1.44,;4.55,.1,;1.89,.1,;3.22,.87,)|	InChI=1S/C17H9ClF3N5OS/c18-10-3-1-2-4-11(10)26-15-9(5-6-12(23-15)17(19,20)21)14(25-16(26)27)24-13-7-28-8-22-13/h1-8H,(H,24,25,27)	SVJPSWNHEAUSLN-UHFFFAOYSA-N	508396	US11130759, Cpd. No. 707::US11046691, Compound 707::1-(2-chlorophenyl)-4-(thiazol-4- ylamino)-7-(trifluoromethyl) pyrido[2,3-d]-pyrimidin-2(1H)-one::US11084798, Cpd No 707	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508396&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608974	459093470							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072251	FC(F)(F)c1ccc2c(NCc3cnoc3)nc(=O)n(-c3ccccc3Cl)c2n1 |(5.89,-1.16,;4.55,-.39,;5.32,.95,;3.78,-1.72,;3.22,.38,;3.22,1.92,;1.89,2.69,;.55,1.92,;-.78,2.69,;-.78,4.23,;-2.12,5,;-3.45,4.23,;-4.86,4.86,;-5.89,3.72,;-5.12,2.38,;-3.61,2.7,;-2.12,1.92,;-2.12,.38,;-3.45,-.39,;-.78,-.39,;-.78,-1.93,;-2.12,-2.69,;-2.12,-4.23,;-.78,-5,;.55,-4.23,;.55,-2.7,;1.89,-1.93,;.55,.38,;1.89,-.39,)|	InChI=1S/C18H11ClF3N5O2/c19-12-3-1-2-4-13(12)27-16-11(5-6-14(25-16)18(20,21)22)15(26-17(27)28)23-7-10-8-24-29-9-10/h1-6,8-9H,7H2,(H,23,26,28)	GAXNYDGVNPQLLD-UHFFFAOYSA-N	508397	US11130759, Cpd. No. 708::US11046691, Compound 708::1-(2-chlorophenyl)-4-((isoxazol-4-yl- methyl)amino)-7-(trifluoromethyl) pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 708	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508397&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608372	459093471							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072252	FC(F)(F)c1ccc2c(NCc3ccon3)nc(=O)n(-c3ccccc3Cl)c2n1 |(5.89,-1.16,;4.55,-.39,;5.32,.95,;3.78,-1.72,;3.22,.38,;3.22,1.92,;1.89,2.69,;.55,1.92,;-.78,2.69,;-.78,4.23,;-2.12,5,;-3.45,4.23,;-4.86,4.86,;-5.89,3.72,;-5.12,2.38,;-3.61,2.7,;-2.12,1.92,;-2.12,.38,;-3.45,-.39,;-.78,-.39,;-.78,-1.93,;-2.12,-2.69,;-2.12,-4.23,;-.78,-5,;.55,-4.23,;.55,-2.7,;1.89,-1.93,;.55,.38,;1.89,-.39,)|	InChI=1S/C18H11ClF3N5O2/c19-12-3-1-2-4-13(12)27-16-11(5-6-14(24-16)18(20,21)22)15(25-17(27)28)23-9-10-7-8-29-26-10/h1-8H,9H2,(H,23,25,28)	PMKAWMZECCGIGY-UHFFFAOYSA-N	508398	US11130759, Cpd. No. 709::US11046691, Compound 709::1-(2-chlorophenyl)-4-((isoxazol-3-yl- methyl)amino)-7-(trifluoromethyl) pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 709	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508398&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608427	459093472							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072253	FC(F)(F)c1ccc2c(NCc3ccno3)nc(=O)n(-c3ccccc3Cl)c2n1 |(5.89,-1.16,;4.55,-.39,;5.32,.95,;3.78,-1.72,;3.22,.38,;3.22,1.92,;1.89,2.69,;.55,1.92,;-.78,2.69,;-.78,4.23,;-2.12,5,;-3.45,4.23,;-4.86,4.86,;-5.89,3.72,;-5.12,2.38,;-3.61,2.7,;-2.12,1.92,;-2.12,.38,;-3.45,-.39,;-.78,-.39,;-.78,-1.93,;-2.12,-2.69,;-2.12,-4.23,;-.78,-5,;.55,-4.23,;.55,-2.7,;1.89,-1.93,;.55,.38,;1.89,-.39,)|	InChI=1S/C18H11ClF3N5O2/c19-12-3-1-2-4-13(12)27-16-11(5-6-14(25-16)18(20,21)22)15(26-17(27)28)23-9-10-7-8-24-29-10/h1-8H,9H2,(H,23,26,28)	XZNPPEYIHQXDFF-UHFFFAOYSA-N	508399	US11130759, Cpd. No. 710::US11046691, Compound 710::1-(2-chlorophenyl)-4-((isoxazol-5-yl- methyl)amino)-7-(trifluoromethyl) pyrido[2,3-d]pyrimidin-2(1H)-one::US11084798, Cpd No 710	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508399&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608803	459093473							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072254	Cn1nccc1CNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |(-5.18,5.73,;-4.86,4.22,;-5.89,3.04,;-5.12,1.7,;-3.61,2.02,;-3.45,3.55,;-2.12,4.32,;-.78,3.55,;-.78,2.01,;-2.12,1.24,;-2.12,-.3,;-3.45,-1.07,;-.78,-1.07,;-.78,-2.61,;-2.12,-3.38,;-2.12,-4.92,;-.78,-5.69,;.55,-4.92,;.55,-3.38,;1.89,-2.61,;.55,-.3,;1.89,-1.07,;3.22,-.3,;3.22,1.24,;1.89,2.01,;.55,1.24,;4.55,-1.07,;5.89,-1.84,;5.32,.27,;3.78,-2.4,)|	InChI=1S/C19H14ClF3N6O/c1-28-11(8-9-25-28)10-24-16-12-6-7-15(19(21,22)23)26-17(12)29(18(30)27-16)14-5-3-2-4-13(14)20/h2-9H,10H2,1H3,(H,24,27,30)	DSFVWNCGPQAKBF-UHFFFAOYSA-N	508400	US11130759, Cpd. No. 711::US11046691, Compound 711::1-(2-chlorophenyl)-4-(((1-methyl-1H- pyrazol-5-yl)methyl)amino)-7- (trifluoro-methyl)pyrido[2,3- d]pyrimidin-2(1H)-one::US11084798, Cpd No 711	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508400	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508400&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608789	459093474							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072255	Cn1cnc(CNc2nc(=O)n(-c3ccccc3Cl)c3nc(ccc23)C(F)(F)F)c1 |(-5.76,.94,;-5.13,2.35,;-5.89,3.72,;-4.86,4.86,;-3.45,4.23,;-2.12,5,;-.78,4.23,;-.78,2.69,;-2.12,1.92,;-2.12,.38,;-3.45,-.39,;-.78,-.39,;-.78,-1.93,;-2.12,-2.69,;-2.12,-4.23,;-.78,-5,;.55,-4.23,;.55,-2.7,;1.89,-1.93,;.55,.38,;1.89,-.39,;3.22,.38,;3.22,1.92,;1.89,2.69,;.55,1.92,;4.55,-.39,;5.89,-1.16,;5.32,.95,;3.78,-1.72,;-3.61,2.7,)|	InChI=1S/C19H14ClF3N6O/c1-28-9-11(25-10-28)8-24-16-12-6-7-15(19(21,22)23)26-17(12)29(18(30)27-16)14-5-3-2-4-13(14)20/h2-7,9-10H,8H2,1H3,(H,24,27,30)	UPIXBBPTSPUFJJ-UHFFFAOYSA-N	508401	US11130759, Cpd. No. 712::US11046691, Compound 712::2-chlorophenyl)-4-(((1-methyl-1H- imidazol-4-yl)methyl)amino)-7- (trifluoro-methyl)-pyrido[2,3-d]- pyrimidin-2(1H)-one::US11084798, Cpd No 712	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508401	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508401&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608816	459093475							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072256	CNc1nc(=O)n(-c2cnccn2)c2cc(ccc12)C1CC1	InChI=1S/C16H15N5O/c1-17-15-12-5-4-11(10-2-3-10)8-13(12)21(16(22)20-15)14-9-18-6-7-19-14/h4-10H,2-3H2,1H3,(H,17,20,22)	DDOIRSNTIJURSW-UHFFFAOYSA-N	508402	US11130759, Cpd. No. 713::US11046691, Compound 713::cyclopropyl-4-(methylamino)-1- (pyrazin-2-yl)quinazolin-2(1H)-one::US11084798, Cpd No 713	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508402&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147341409	459093476							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072257	CNc1nc(=O)n(-c2cncnc2)c2cc(ccc12)C1CC1	InChI=1S/C16H15N5O/c1-17-15-13-5-4-11(10-2-3-10)6-14(13)21(16(22)20-15)12-7-18-9-19-8-12/h4-10H,2-3H2,1H3,(H,17,20,22)	UEJVSZUOGQYQLY-UHFFFAOYSA-N	508403	US11130759, Cpd. No. 714::US11046691, Compound 714::7-cyclopropyl-4-(methylamino)-1- (pyrimidin-5-yl)quinazolin-2(1H)-one::US11084798, Cpd No 714	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508403	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508403&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151989608	459093477							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072258	Nc1nc(=O)n(-c2ncccc2Cl)c2cc(ccc12)C1CC1 |(-4.1,.87,;-2.77,.1,;-2.77,-1.44,;-1.44,-2.21,;-1.44,-3.75,;-.1,-1.44,;1.23,-2.21,;2.56,-1.44,;3.9,-2.21,;3.9,-3.75,;2.56,-4.52,;1.23,-3.75,;-.1,-4.52,;-.1,.1,;1.23,.87,;1.23,2.41,;-.1,3.18,;-1.44,2.41,;-1.44,.87,;2.56,3.18,;4.1,3.18,;3.33,4.52,)|	InChI=1S/C16H13ClN4O/c17-12-2-1-7-19-15(12)21-13-8-10(9-3-4-9)5-6-11(13)14(18)20-16(21)22/h1-2,5-9H,3-4H2,(H2,18,20,22)	ITFFCZPYHRUUGS-UHFFFAOYSA-N	508404	US11130759, Cpd. No. 715::US11046691, Compound 715::4-amino-1-(3-chloropyridin-2-yl)-7- cyclopropylquinazolin-2(1H)-one::US11084798, Cpd No 715	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508404	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508404&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150607635	459093478							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072259	Nc1nc(=O)n(-c2cnccn2)c2cc(ccc12)C1CC1	InChI=1S/C15H13N5O/c16-14-11-4-3-10(9-1-2-9)7-12(11)20(15(21)19-14)13-8-17-5-6-18-13/h3-9H,1-2H2,(H2,16,19,21)	XPIHDOZMMAXRFE-UHFFFAOYSA-N	508405	US11130759, Cpd. No. 716::US11046691, Compound 716::4-amino-7-cyclopropyl-1-(pyrazin-2- yl)-quinazolin-2(1H)-one::US11084798, Cpd No 716	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508405	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508405&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152430308	459093479							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072260	Nc1nc(=O)n(-c2cncnc2)c2cc(ccc12)C1CC1	InChI=1S/C15H13N5O/c16-14-12-4-3-10(9-1-2-9)5-13(12)20(15(21)19-14)11-6-17-8-18-7-11/h3-9H,1-2H2,(H2,16,19,21)	SBHVMQOOYHHSGV-UHFFFAOYSA-N	508406	US11130759, Cpd. No. 717::US11046691, Compound 717::4-amino-7-cyclopropyl-1-(pyrimidin-5- yl)quinazolin-2(1H)-one::US11084798, Cpd No 717	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508406	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508406&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151814499	459093480							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072261	O[C@@H]1CC[C@H]1Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F |r|	InChI=1S/C19H16F3N3O2/c20-19(21,22)11-6-7-13-15(10-11)25(12-4-2-1-3-5-12)18(27)24-17(13)23-14-8-9-16(14)26/h1-7,10,14,16,26H,8-9H2,(H,23,24,27)	RRNGVMIZQGLNFJ-UHFFFAOYSA-N	508407	US11130759, Cpd. No. 718::US11046691, Compound 718::4-((trans-2-hydroxycyclobutyl) amino)- 1-phenyl-7-(trifluoromethyl) quinazolin-2(1H)-one::US11084798, Cpd No 718	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508407&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151765671	459093481							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072262	CNc1nc(=O)n(-c2ccccc2Br)c2cc(ccc12)C1CC1 |(.77,5,;2.1,4.23,;2.1,2.69,;3.44,1.93,;3.44,.38,;4.77,-.38,;2.1,-.38,;2.1,-1.93,;3.44,-2.69,;3.44,-4.23,;2.1,-5,;.77,-4.23,;.77,-2.69,;-.56,-1.93,;.77,.38,;-.56,-.38,;-1.9,.38,;-1.9,1.93,;-.56,2.69,;.77,1.93,;-3.23,-.38,;-4.77,-.38,;-4,-1.72,)|	InChI=1S/C18H16BrN3O/c1-20-17-13-9-8-12(11-6-7-11)10-16(13)22(18(23)21-17)15-5-3-2-4-14(15)19/h2-5,8-11H,6-7H2,1H3,(H,20,21,23)	CASGOCXGOIAVHT-UHFFFAOYSA-N	507940	US11130759, Cpd. No. 719::US11046691, Compound 351::1-(2-bromophenyl)-7-cyclopropyl-4- (methylamino)hydroquinazolin-2-one::US11084798, Cpd No 719	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507940&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147187176	459093022							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072263	COc1cc(cc2n(-c3ccccc3Cl)c(=O)nc(NC(C)C)c12)C1CC1 |(-1.17,4.7,;-1.44,3.18,;-.1,2.41,;1.23,3.18,;2.56,2.41,;2.56,.87,;1.23,.1,;1.23,-1.44,;2.56,-2.21,;2.56,-3.75,;3.9,-4.52,;5.23,-3.75,;5.23,-2.21,;3.9,-1.44,;3.9,.1,;-.1,-2.21,;-.1,-3.75,;-1.44,-1.44,;-1.44,.1,;-2.77,.87,;-4.1,.1,;-5.44,.87,;-4.1,-1.44,;-.1,.87,;3.9,3.18,;5.44,3.18,;4.67,4.52,)|	InChI=1S/C21H22ClN3O2/c1-12(2)23-20-19-17(10-14(13-8-9-13)11-18(19)27-3)25(21(26)24-20)16-7-5-4-6-15(16)22/h4-7,10-13H,8-9H2,1-3H3,(H,23,24,26)	OJIQHHPQYOYYRN-UHFFFAOYSA-N	508409	US11046691, Compound 720::1-(2-chlorophenyl)-7-cyclopropyl-4- (isopropylamino)-5-methoxy quinazolin-2(1H)-one::US11084798, Cpd No 720	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508409&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608373	459093483							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072264	COc1cc(cc2n(-c3ccccc3Cl)c(=O)nc(NC3CC3)c12)C1CC1 |(-1.07,4.7,;-1.33,3.18,;,2.41,;1.33,3.18,;2.67,2.41,;2.67,.87,;1.33,.1,;1.33,-1.44,;2.67,-2.21,;2.67,-3.75,;4,-4.52,;5.33,-3.75,;5.33,-2.21,;4,-1.44,;4,.1,;,-2.21,;,-3.75,;-1.33,-1.44,;-1.33,.1,;-2.67,.87,;-4,.1,;-5.54,.1,;-4.77,-1.23,;,.87,;4,3.18,;5.54,3.18,;4.77,4.52,)|	InChI=1S/C21H20ClN3O2/c1-27-18-11-13(12-6-7-12)10-17-19(18)20(23-14-8-9-14)24-21(26)25(17)16-5-3-2-4-15(16)22/h2-5,10-12,14H,6-9H2,1H3,(H,23,24,26)	NVQYOTLCZSZCOJ-UHFFFAOYSA-N	508410	US11130759, Cpd. No. 721::US11046691, Compound 721::1-(2-chlorophenyl)-7-cyclopropyl-4- (cyclopropylamino)-5-methoxy- quinazolin-2(1H)-one::US11084798, Cpd No 721	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508410	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508410&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608748	459093484							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072265	COc1cc(cc2n(-c3ccccc3Cl)c(=O)nc(N[C@H]3C[C@H]3F)c12)C1CC1 |r,wD:20.20,22.24,(-1.07,4.7,;-1.33,3.18,;,2.41,;1.33,3.18,;2.67,2.41,;2.67,.87,;1.33,.1,;1.33,-1.44,;2.67,-2.21,;2.67,-3.75,;4,-4.52,;5.33,-3.75,;5.33,-2.21,;4,-1.44,;4,.1,;,-2.21,;,-3.75,;-1.33,-1.44,;-1.33,.1,;-2.67,.87,;-4,.1,;-5.54,.1,;-4.77,-1.23,;-4.77,-2.77,;,.87,;4,3.18,;5.54,3.18,;4.77,4.52,)|	InChI=1S/C21H19ClFN3O2/c1-28-18-9-12(11-6-7-11)8-17-19(18)20(24-15-10-14(15)23)25-21(27)26(17)16-5-3-2-4-13(16)22/h2-5,8-9,11,14-15H,6-7,10H2,1H3,(H,24,25,27)	WNWZYHJGHZEILQ-UHFFFAOYSA-N	508411	US11130759, Cpd. No. 722::US11046691, Compound 722::1-(2-chlorophenyl)-7-cyclopropyl-4- (((lS,2R)-2-fluorocyclopropyl) amino)- 5-methoxyquinazolin-2(1H)-one::US11084798, Cpd No 722	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508411	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508411&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608335	459093485							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072266	COc1cc(cc2n(-c3ccccc3Cl)c(=O)nc(NCC3CC3)c12)C1CC1 |(-.4,4.7,;-.67,3.18,;.67,2.41,;2,3.18,;3.33,2.41,;3.33,.87,;2,.1,;2,-1.44,;3.33,-2.21,;3.33,-3.75,;4.67,-4.52,;6,-3.75,;6,-2.21,;4.67,-1.44,;4.67,.1,;.67,-2.21,;.67,-3.75,;-.67,-1.44,;-.67,.1,;-2,.87,;-3.33,.1,;-4.67,.87,;-5.44,2.21,;-6.21,.87,;.67,.87,;4.67,3.18,;6.21,3.18,;5.44,4.52,)|	InChI=1S/C22H22ClN3O2/c1-28-19-11-15(14-8-9-14)10-18-20(19)21(24-12-13-6-7-13)25-22(27)26(18)17-5-3-2-4-16(17)23/h2-5,10-11,13-14H,6-9,12H2,1H3,(H,24,25,27)	YRQGQJDXKJOIAR-UHFFFAOYSA-N	508412	US11130759, Cpd. No. 723::US11046691, Compound 723::1-(2-chlorophenyl)-7-cyclopropyl-4- ((cyclopropylmethyl)amino)-5- methoxy-quinazolin-2(1H)-one::US11084798, Cpd No 723	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508412&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608809	459093486							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072267	COc1cc(cc2n(-c3ccccc3Cl)c(=O)nc(NCC3CC3(F)F)c12)C1CC1 |(.27,4.7,;,3.18,;1.33,2.41,;2.67,3.18,;4,2.41,;4,.87,;2.67,.1,;2.67,-1.44,;4,-2.21,;4,-3.75,;5.33,-4.52,;6.67,-3.75,;6.67,-2.21,;5.33,-1.44,;5.33,.1,;1.33,-2.21,;1.33,-3.75,;,-1.44,;,.1,;-1.33,.87,;-2.67,.1,;-4,.87,;-4.77,2.21,;-5.54,.87,;-6.87,1.64,;-6.87,.1,;1.33,.87,;5.33,3.18,;6.87,3.18,;6.1,4.52,)|	InChI=1S/C22H20ClF2N3O2/c1-30-18-9-13(12-6-7-12)8-17-19(18)20(26-11-14-10-22(14,24)25)27-21(29)28(17)16-5-3-2-4-15(16)23/h2-5,8-9,12,14H,6-7,10-11H2,1H3,(H,26,27,29)	ATQDEKGNLFLKAA-UHFFFAOYSA-N	508413	US11130759, Cpd. No. 724::US11046691, Compound 724::1-(2-chlorophenyl)-7-cyclopropyl-4- (((2,2-difluorocyclopropyl)methyl)- amino)-5-methoxyquinazolin-2(1H)- one::US11084798, Cpd No 724	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508413&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147009691	459093487							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072268	CNc1nc(=O)n(-c2cccnc2Cl)c2cc(ccc12)C1CC1 |(-5.44,.1,;-4.1,.87,;-2.77,.1,;-2.77,-1.44,;-1.44,-2.21,;-1.44,-3.75,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-4.52,;3.9,-3.75,;3.9,-2.21,;2.56,-1.44,;2.56,.1,;-.1,.1,;1.23,.87,;1.23,2.41,;-.1,3.18,;-1.44,2.41,;-1.44,.87,;2.56,3.18,;4.1,3.18,;3.33,4.52,)|	InChI=1S/C17H15ClN4O/c1-19-16-12-7-6-11(10-4-5-10)9-14(12)22(17(23)21-16)13-3-2-8-20-15(13)18/h2-3,6-10H,4-5H2,1H3,(H,19,21,23)	LINFNRHTTSDXJI-UHFFFAOYSA-N	508414	US11130759, Cpd. No. 725::US11046691, Compound 725::1-(2-chloropyridin-3-yl)-7-cyclopropyl- 4-(methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 725	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508414	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508414&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148351140	459093488							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072269	COc1nc(=O)n(-c2cccnc2Cl)c2cc(ccc12)C1CC1 |(-5.44,.1,;-4.1,.87,;-2.77,.1,;-2.77,-1.44,;-1.44,-2.21,;-1.44,-3.75,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-4.52,;3.9,-3.75,;3.9,-2.21,;2.56,-1.44,;2.56,.1,;-.1,.1,;1.23,.87,;1.23,2.41,;-.1,3.18,;-1.44,2.41,;-1.44,.87,;2.56,3.18,;4.1,3.18,;3.33,4.52,)|	InChI=1S/C17H14ClN3O2/c1-23-16-12-7-6-11(10-4-5-10)9-14(12)21(17(22)20-16)13-3-2-8-19-15(13)18/h2-3,6-10H,4-5H2,1H3	QZMPNLGRIHDBFO-UHFFFAOYSA-N	508415	US11130759, Cpd. No. 726::US11046691, Compound 726::1-(2-chloropyridin-3-yl)-7-cyclopropyl- 4-methoxyquinazolin-2(1H)-one::US11084798, Cpd No 726	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508415	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508415&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608852	459093489							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072270	COc1cc(cc2n(-c3cccnc3Cl)c(=O)ncc12)C1CC1 |(-3.17,4.7,;-3.44,3.18,;-2.1,2.41,;-.77,3.18,;.56,2.41,;.56,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-4.52,;3.23,-3.75,;3.23,-2.21,;1.9,-1.44,;1.9,.1,;-2.1,-2.21,;-2.1,-3.75,;-3.44,-1.44,;-3.44,.1,;-2.1,.87,;1.9,3.18,;3.44,3.18,;2.67,4.52,)|	InChI=1S/C17H14ClN3O2/c1-23-15-8-11(10-4-5-10)7-14-12(15)9-20-17(22)21(14)13-3-2-6-19-16(13)18/h2-3,6-10H,4-5H2,1H3	FYBMBSHMRPGAEO-UHFFFAOYSA-N	512391	US11084798, Cpd No 727::1-(2-chloropyridin-3-yl)-7-cyclopropyl- 5-methoxy-4-(methylamino)quinazolin- 2(1H)-one	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=512391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=512391&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162533581	459629638							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072271	F[C@@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |r,wU:3.4,wD:1.0,(-5.44,3.57,;-4.1,4.34,;-3.33,5.67,;-2.56,4.34,;-1.23,3.57,;-1.23,2.03,;-2.56,1.26,;-2.56,-.28,;-3.9,-1.05,;-1.23,-1.05,;-1.23,-2.59,;.1,-3.36,;.1,-4.9,;-1.23,-5.67,;-2.56,-4.9,;-2.56,-3.36,;-3.9,-2.59,;.1,-.28,;1.44,-1.05,;2.77,-.28,;2.77,1.26,;1.44,2.03,;.1,1.26,;4.1,-1.05,;5.44,-.28,;4.1,.49,;4.1,-2.59,)|	InChI=1S/C18H12ClF4N3O/c19-11-3-1-2-4-14(11)26-15-7-9(18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	KOFRWFSRZWFLEJ-UHFFFAOYSA-N	508417	US11130759, Cpd. No. 729::1-(2-chlorophenyl)-4-(((1S,2S)-2- fluorocyclopropyl)amino)-7- (trifluoromethyl)-quinazolin-2(1H)-one, single unknown enantiomer/atropisomer::US11046691, Compound 729::US11046691, Compound 728::US11084798, Cpd No 729	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508417&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608234	459093491							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072272	F[C@@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |r,wU:3.4,wD:1.0,(-5.44,3.57,;-4.1,4.34,;-3.33,5.67,;-2.56,4.34,;-1.23,3.57,;-1.23,2.03,;-2.56,1.26,;-2.56,-.28,;-3.9,-1.05,;-1.23,-1.05,;-1.23,-2.59,;.1,-3.36,;.1,-4.9,;-1.23,-5.67,;-2.56,-4.9,;-2.56,-3.36,;-3.9,-2.59,;.1,-.28,;1.44,-1.05,;2.77,-.28,;2.77,1.26,;1.44,2.03,;.1,1.26,;4.1,-1.05,;5.44,-.28,;4.1,.49,;4.1,-2.59,)|	InChI=1S/C18H12ClF4N3O/c19-11-3-1-2-4-14(11)26-15-7-9(18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	KOFRWFSRZWFLEJ-UHFFFAOYSA-N	508417	US11130759, Cpd. No. 729::1-(2-chlorophenyl)-4-(((1S,2S)-2- fluorocyclopropyl)amino)-7- (trifluoromethyl)-quinazolin-2(1H)-one, single unknown enantiomer/atropisomer::US11046691, Compound 729::US11046691, Compound 728::US11084798, Cpd No 729	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508417&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608234	459093491							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072273	F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |r,wU:1.0,wD:3.4,(-5.44,3.57,;-4.1,4.34,;-3.33,5.67,;-2.56,4.34,;-1.23,3.57,;-1.23,2.03,;-2.56,1.26,;-2.56,-.28,;-3.9,-1.05,;-1.23,-1.05,;-1.23,-2.59,;.1,-3.36,;.1,-4.9,;-1.23,-5.67,;-2.56,-4.9,;-2.56,-3.36,;-3.9,-2.59,;.1,-.28,;1.44,-1.05,;2.77,-.28,;2.77,1.26,;1.44,2.03,;.1,1.26,;4.1,-1.05,;5.44,-.28,;4.1,.49,;4.1,-2.59,)|	InChI=1S/C18H12ClF4N3O/c19-11-3-1-2-4-14(11)26-15-7-9(18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	KOFRWFSRZWFLEJ-UHFFFAOYSA-N	508419	US11130759, Cpd. No. 731::US11046691, Compound 731::1-(2-chlorophenyl)-4-(((1R,2R)-2- fluorocyclopropyl)amino)-7- (trifluoromethyl)-quinazolin-2(1H)-one, single unknown enantiomer/atropisomer::US11046691, Compound 730::US11084798, Cpd No 731	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508419&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608215	459093492							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072274	F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F |r,wU:1.0,wD:3.4,(-5.44,3.57,;-4.1,4.34,;-3.33,5.67,;-2.56,4.34,;-1.23,3.57,;-1.23,2.03,;-2.56,1.26,;-2.56,-.28,;-3.9,-1.05,;-1.23,-1.05,;-1.23,-2.59,;.1,-3.36,;.1,-4.9,;-1.23,-5.67,;-2.56,-4.9,;-2.56,-3.36,;-3.9,-2.59,;.1,-.28,;1.44,-1.05,;2.77,-.28,;2.77,1.26,;1.44,2.03,;.1,1.26,;4.1,-1.05,;5.44,-.28,;4.1,.49,;4.1,-2.59,)|	InChI=1S/C18H12ClF4N3O/c19-11-3-1-2-4-14(11)26-15-7-9(18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	KOFRWFSRZWFLEJ-UHFFFAOYSA-N	508419	US11130759, Cpd. No. 731::US11046691, Compound 731::1-(2-chlorophenyl)-4-(((1R,2R)-2- fluorocyclopropyl)amino)-7- (trifluoromethyl)-quinazolin-2(1H)-one, single unknown enantiomer/atropisomer::US11046691, Compound 730::US11084798, Cpd No 731	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508419&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608215	459093492							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072275	F[C@@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |r,wU:3.4,wD:1.0,(-5.54,3.57,;-4.21,4.34,;-3.44,5.67,;-2.67,4.34,;-1.33,3.57,;-1.33,2.03,;-2.67,1.26,;-2.67,-.28,;-4,-1.05,;-1.33,-1.05,;-1.33,-2.59,;,-3.36,;,-4.9,;-1.33,-5.67,;-2.67,-4.9,;-2.67,-3.36,;-4,-2.59,;,-.28,;1.33,-1.05,;2.67,-.28,;2.67,1.26,;1.33,2.03,;,1.26,;4,-1.05,;4.77,-2.39,;5.54,-1.05,)|	InChI=1S/C20H17ClFN3O/c21-14-3-1-2-4-17(14)25-18-9-12(11-5-6-11)7-8-13(18)19(24-20(25)26)23-16-10-15(16)22/h1-4,7-9,11,15-16H,5-6,10H2,(H,23,24,26)	OFKNVVVDSFLNGX-UHFFFAOYSA-N	508421	US11130759, Cpd. No. 732::US11046691, Compound 732::1-(2-chlorophenyl)-7-cyclopropyl-4- (((1S,2S)-2-fluorocyclopropyl)amino)- quinazolin-2(1H)-one, single unknown enantiomer/atropisomer::US11084798, Cpd No 732	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508421&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933623	459093493							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072276	F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |r,wU:1.0,wD:3.4,(-5.54,3.57,;-4.21,4.34,;-3.44,5.67,;-2.67,4.34,;-1.33,3.57,;-1.33,2.03,;-2.67,1.26,;-2.67,-.28,;-4,-1.05,;-1.33,-1.05,;-1.33,-2.59,;,-3.36,;,-4.9,;-1.33,-5.67,;-2.67,-4.9,;-2.67,-3.36,;-4,-2.59,;,-.28,;1.33,-1.05,;2.67,-.28,;2.67,1.26,;1.33,2.03,;,1.26,;4,-1.05,;4.77,-2.39,;5.54,-1.05,)|	InChI=1S/C20H17ClFN3O/c21-14-3-1-2-4-17(14)25-18-9-12(11-5-6-11)7-8-13(18)19(24-20(25)26)23-16-10-15(16)22/h1-4,7-9,11,15-16H,5-6,10H2,(H,23,24,26)	OFKNVVVDSFLNGX-UHFFFAOYSA-N	508422	US11130759, Cpd. No. 734::1-(2-chlorophenyl)-7-cyclopropyl-4- (((1S,2S)-2-fluorocyclopropyl)amino)- quinazolin-2(1H)-one, single unknown enantiomer/atropisomer::US11046691, Compound 734::US11046691, Compound 733::US11084798, Cpd No 734	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508422&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148754917	459093494							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072277	F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |r,wU:1.0,wD:3.4,(-5.54,3.57,;-4.21,4.34,;-3.44,5.67,;-2.67,4.34,;-1.33,3.57,;-1.33,2.03,;-2.67,1.26,;-2.67,-.28,;-4,-1.05,;-1.33,-1.05,;-1.33,-2.59,;,-3.36,;,-4.9,;-1.33,-5.67,;-2.67,-4.9,;-2.67,-3.36,;-4,-2.59,;,-.28,;1.33,-1.05,;2.67,-.28,;2.67,1.26,;1.33,2.03,;,1.26,;4,-1.05,;4.77,-2.39,;5.54,-1.05,)|	InChI=1S/C20H17ClFN3O/c21-14-3-1-2-4-17(14)25-18-9-12(11-5-6-11)7-8-13(18)19(24-20(25)26)23-16-10-15(16)22/h1-4,7-9,11,15-16H,5-6,10H2,(H,23,24,26)	OFKNVVVDSFLNGX-UHFFFAOYSA-N	508422	US11130759, Cpd. No. 734::1-(2-chlorophenyl)-7-cyclopropyl-4- (((1S,2S)-2-fluorocyclopropyl)amino)- quinazolin-2(1H)-one, single unknown enantiomer/atropisomer::US11046691, Compound 734::US11046691, Compound 733::US11084798, Cpd No 734	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508422&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			148754917	459093494							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072278	Clc1ncccc1-n1c2cc(ccc2c(NCC2CC2)nc1=O)C1CC1 |(4.67,.1,;4.67,-1.44,;6,-2.21,;6,-3.75,;4.67,-4.52,;3.33,-3.75,;3.33,-2.21,;2,-1.44,;2,.1,;3.33,.87,;3.33,2.41,;2,3.18,;.67,2.41,;.67,.87,;-.67,.1,;-2,.87,;-3.33,.1,;-4.67,.87,;-5.44,2.21,;-6.21,.87,;-.67,-1.44,;.67,-2.21,;.67,-3.75,;4.67,3.18,;6.21,3.18,;5.44,4.52,)|	InChI=1S/C20H19ClN4O/c21-18-16(2-1-9-22-18)25-17-10-14(13-5-6-13)7-8-15(17)19(24-20(25)26)23-11-12-3-4-12/h1-2,7-10,12-13H,3-6,11H2,(H,23,24,26)	CUPXXEYERHHTJR-UHFFFAOYSA-N	508424	US11130759, Cpd. No. 735::US11046691, Compound 735::1-(2-chloropyridin-3-yl)-7-cyclopropyl- 4-((cyclopropylmethyl)amino)- quinazolin-2(1H)-one::US11084798, Cpd No 735	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508424	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508424&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608995	459093495							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072279	F[C@@H]1C[C@@H]1Nc1nc(=O)n(-c2cccnc2Cl)c2cc(ccc12)C1CC1 |r,wD:3.4,1.0,(-4.77,-2.77,;-4.77,-1.23,;-5.54,.1,;-4,.1,;-2.67,.87,;-1.33,.1,;-1.33,-1.44,;,-2.21,;,-3.75,;1.33,-1.44,;2.67,-2.21,;2.67,-3.75,;4,-4.52,;5.33,-3.75,;5.33,-2.21,;4,-1.44,;4,.1,;1.33,.1,;2.67,.87,;2.67,2.41,;1.33,3.18,;,2.41,;,.87,;4,3.18,;5.54,3.18,;4.77,4.52,)|	InChI=1S/C19H16ClFN4O/c20-17-15(2-1-7-22-17)25-16-8-11(10-3-4-10)5-6-12(16)18(24-19(25)26)23-14-9-13(14)21/h1-2,5-8,10,13-14H,3-4,9H2,(H,23,24,26)	KNGXSVODAUZPHQ-UHFFFAOYSA-N	508425	US11130759, Cpd. No. 736::US11046691, Compound 736::1-(2-chloropyridin-3-yl)-7-cyclopropyl- 4-(((lS,2R)-2-fluorocyclopropyl) amino)-quinazolin-2(1H)-one::US11084798, Cpd No 736	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508425&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933692	459093496							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072280	CC(F)(F)c1ccc2c(N[C@@H]3CC[C@H]3O)nc(=O)n(-c3ccccc3Cl)c2c1 |r,wU:13.14,wD:10.9,(2.2,-2.49,;2.97,-1.16,;4.31,-1.93,;3.74,.17,;1.64,-.39,;1.64,1.15,;.31,1.92,;-1.03,1.15,;-2.36,1.92,;-2.36,3.46,;-1.03,4.23,;-.63,5.72,;.86,5.32,;.46,3.83,;1.23,2.5,;-3.69,1.15,;-3.69,-.39,;-5.03,-1.16,;-2.36,-1.16,;-2.36,-2.7,;-1.03,-3.47,;-1.03,-5.01,;-2.36,-5.78,;-3.69,-5.01,;-3.69,-3.47,;-5.03,-2.7,;-1.03,-.39,;.31,-1.16,)|	InChI=1S/C20H18ClF2N3O2/c1-20(22,23)11-6-7-12-16(10-11)26(15-5-3-2-4-13(15)21)19(28)25-18(12)24-14-8-9-17(14)27/h2-7,10,14,17,27H,8-9H2,1H3,(H,24,25,28)	IYJWELSCEOAHJZ-UHFFFAOYSA-N	508426	US11130759, Cpd. No. 738::1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4-(((1R,2R)-2- hydroxycyclobutyl)-aminolquinazolin- 2(1H)-one, single unknown enantiomer/atropisomer::US11046691, Compound 738::US11046691, Compound 737::US11084798, Cpd No 738	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508426&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608362	459093497							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072281	CC(F)(F)c1ccc2c(N[C@@H]3CC[C@H]3O)nc(=O)n(-c3ccccc3Cl)c2c1 |r,wU:13.14,wD:10.9,(2.2,-2.49,;2.97,-1.16,;4.31,-1.93,;3.74,.17,;1.64,-.39,;1.64,1.15,;.31,1.92,;-1.03,1.15,;-2.36,1.92,;-2.36,3.46,;-1.03,4.23,;-.63,5.72,;.86,5.32,;.46,3.83,;1.23,2.5,;-3.69,1.15,;-3.69,-.39,;-5.03,-1.16,;-2.36,-1.16,;-2.36,-2.7,;-1.03,-3.47,;-1.03,-5.01,;-2.36,-5.78,;-3.69,-5.01,;-3.69,-3.47,;-5.03,-2.7,;-1.03,-.39,;.31,-1.16,)|	InChI=1S/C20H18ClF2N3O2/c1-20(22,23)11-6-7-12-16(10-11)26(15-5-3-2-4-13(15)21)19(28)25-18(12)24-14-8-9-17(14)27/h2-7,10,14,17,27H,8-9H2,1H3,(H,24,25,28)	IYJWELSCEOAHJZ-UHFFFAOYSA-N	508426	US11130759, Cpd. No. 738::1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4-(((1R,2R)-2- hydroxycyclobutyl)-aminolquinazolin- 2(1H)-one, single unknown enantiomer/atropisomer::US11046691, Compound 738::US11046691, Compound 737::US11084798, Cpd No 738	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508426&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608362	459093497							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072282	CC(F)(F)c1ccc2c(N[C@H]3CC[C@@H]3O)nc(=O)n(-c3ccccc3Cl)c2c1 |r,wU:10.9,wD:13.14,(2.2,-2.49,;2.97,-1.16,;4.31,-1.93,;3.74,.17,;1.64,-.39,;1.64,1.15,;.31,1.92,;-1.03,1.15,;-2.36,1.92,;-2.36,3.46,;-1.03,4.23,;-.63,5.72,;.86,5.32,;.46,3.83,;1.23,2.5,;-3.69,1.15,;-3.69,-.39,;-5.03,-1.16,;-2.36,-1.16,;-2.36,-2.7,;-1.03,-3.47,;-1.03,-5.01,;-2.36,-5.78,;-3.69,-5.01,;-3.69,-3.47,;-5.03,-2.7,;-1.03,-.39,;.31,-1.16,)|	InChI=1S/C20H18ClF2N3O2/c1-20(22,23)11-6-7-12-16(10-11)26(15-5-3-2-4-13(15)21)19(28)25-18(12)24-14-8-9-17(14)27/h2-7,10,14,17,27H,8-9H2,1H3,(H,24,25,28)	IYJWELSCEOAHJZ-UHFFFAOYSA-N	508428	US11130759, Cpd. No. 739::US11046691, Compound 739::1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4-(((1S,2S)-2- hydroxycyclobutyl)-aminolquinazolin- 2(1H)-one, single unknown enantiomer/atropisomer::US11084798, Cpd No 739	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508428&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608454	459093498							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072283	F[C@@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |r,wU:1.0,wD:3.4,(4.2,2.36,;3.8,3.85,;3.8,5.39,;2.47,4.62,;1.13,3.85,;1.13,2.31,;2.47,1.54,;2.47,,;3.8,-.77,;1.13,-.77,;1.13,-2.31,;2.47,-3.08,;2.47,-4.62,;1.13,-5.39,;-.2,-4.62,;-.2,-3.08,;-1.53,-2.31,;-.2,,;-1.53,-.77,;-2.87,,;-4.2,-.77,;-5.38,.22,;-6.56,1.21,;-5.11,1.74,;-6.83,-.31,;-2.87,1.54,;-1.53,2.31,;-.2,1.54,)|	InChI=1S/C18H12ClF4N3O2/c19-11-3-1-2-4-14(11)26-15-7-9(28-18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	CPLJBLXSCDZION-UHFFFAOYSA-N	508097	US11130759, Cpd. No. 740::US11046691, Compound 404::4-[((1R,2R)-2-fluorocyclopropyl)- amino]-1-(2-chlorophenyl)-7- (trifluoromethoxy)hydroquinazolin-2- one::US11084798, Cpd No 404	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508097&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147265774	459093176							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072284	F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 |r,wU:3.4,wD:1.0,(4.77,3.57,;3.44,4.34,;2.67,5.67,;1.9,4.34,;.56,3.57,;.56,2.03,;1.9,1.26,;1.9,-.28,;3.23,-1.05,;.56,-1.05,;.56,-2.59,;1.9,-3.36,;1.9,-4.9,;.56,-5.67,;-.77,-4.9,;-.77,-3.36,;-2.1,-2.59,;-.77,-.28,;-2.1,-1.05,;-3.44,-.28,;-4.77,-1.05,;-5.95,-.06,;-7.13,.93,;-5.68,1.45,;-7.4,-.59,;-3.44,1.26,;-2.1,2.03,;-.77,1.26,)|	InChI=1S/C18H12ClF4N3O2/c19-11-3-1-2-4-14(11)26-15-7-9(28-18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)	CPLJBLXSCDZION-UHFFFAOYSA-N	507810	US11130759, Cpd. No. 741::US11046691, Compound 418::1-(2-chlorophenyl)-4-(((1S,2S)-2- fluorocyclopropyl)amino)-7-(trifluoro- methoxy)quinazolin-2(1H)-one::US11084798, Cpd No 418	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507810&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608906	459092895							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072285	CNc1nc(=O)n(-c2cccnc2Cl)c2cc(C3CC3)c(cc12)C#N |(-3.44,5,;-2.1,4.23,;-2.1,2.69,;-3.44,1.92,;-3.44,.38,;-4.77,-.39,;-2.1,-.39,;-2.1,-1.93,;-3.44,-2.69,;-3.44,-4.23,;-2.1,-5,;-.77,-4.23,;-.77,-2.7,;.56,-1.93,;-.77,.38,;.56,-.39,;1.9,.38,;3.23,-.39,;4,-1.72,;4.77,-.39,;1.9,1.92,;.56,2.69,;-.77,1.92,;3.23,2.69,;4.56,3.46,)|	InChI=1S/C18H14ClN5O/c1-21-17-13-7-11(9-20)12(10-4-5-10)8-15(13)24(18(25)23-17)14-3-2-6-22-16(14)19/h2-3,6-8,10H,4-5H2,1H3,(H,21,23,25)	GIRIGNREXKBRFS-UHFFFAOYSA-N	508431	US11130759, Cpd. No. 742::US11046691, Compound 742::1-(2-chloropyridin-3-yl)-7-cyclopropyl- 4-(methylamino)-2-oxo-1,2-dihydro- quinazoline-6-carbonitrile::US11084798, Cpd No 742	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508431&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608865	459093501							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072286	O[C@@H]1CC[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(cc12)C#N |r,wU:4.5,wD:1.0,(-5.15,2.36,;-4.5,3.75,;-5.03,5.2,;-3.58,5.73,;-3.06,4.28,;-1.72,3.51,;-1.72,1.97,;-3.06,1.2,;-3.06,-.34,;-4.39,-1.11,;-1.72,-1.11,;-1.72,-2.65,;-3.06,-3.42,;-3.06,-4.96,;-1.72,-5.73,;-.39,-4.96,;-.39,-3.42,;.95,-2.65,;-.39,-.34,;.95,-1.11,;2.28,-.34,;3.61,-1.11,;4.38,-2.44,;5.15,-1.11,;2.28,1.2,;.95,1.97,;-.39,1.2,;3.61,1.97,;4.95,2.74,)|	InChI=1S/C22H19ClN4O2/c23-16-3-1-2-4-18(16)27-19-10-14(12-5-6-12)13(11-24)9-15(19)21(26-22(27)29)25-17-7-8-20(17)28/h1-4,9-10,12,17,20,28H,5-8H2,(H,25,26,29)	XPSXEENAJWQVGR-UHFFFAOYSA-N	508432	US11130759, Cpd. No. 743::US11046691, Compound 743::1-(2-chlorophenyl)-7-cyclopropyl-4- (((1S,2S)-2-hydroxycyclobutyl)amino)- 2-oxo-1,2-dihydroquinazoline-6- carbonitrile, single unknown enantiomer/atropisomer::US11084798, Cpd No 743	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508432&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154933698	459093502							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072287	FC(F)(F)c1cc(Nc2nc(=O)n(-c3ccccc3Cl)c3cc(C4CC4)c(cc23)C#N)ccn1 |(-7.44,3.85,;-6.1,3.08,;-6.1,1.54,;-7.44,2.31,;-4.77,3.85,;-3.44,3.08,;-2.1,3.85,;-.77,3.08,;-.77,1.54,;-2.1,.77,;-2.1,-.77,;-3.44,-1.54,;-.77,-1.54,;-.77,-3.08,;-2.1,-3.85,;-2.1,-5.39,;-.77,-6.16,;.56,-5.39,;.56,-3.85,;1.9,-3.08,;.56,-.77,;1.9,-1.54,;3.23,-.77,;4.56,-1.54,;5.33,-2.87,;6.1,-1.54,;3.23,.77,;1.9,1.54,;.56,.77,;4.56,1.54,;5.9,2.31,;-2.1,5.39,;-3.44,6.16,;-4.77,5.39,)|	InChI=1S/C24H15ClF3N5O/c25-18-3-1-2-4-19(18)33-20-11-16(13-5-6-13)14(12-29)9-17(20)22(32-23(33)34)31-15-7-8-30-21(10-15)24(26,27)28/h1-4,7-11,13H,5-6H2,(H,30,31,32,34)	CBWUXJIRMANJOJ-UHFFFAOYSA-N	508433	US11130759, Cpd. No. 744::US11046691, Compound 744::1-(2-chlorophenyl)-7-cyclopropyl-2- oxo-4-((2-(trifluoromethyl)pyridin-4- yl)-amino)-1,2-dihydroquinazoline-6- carbonitrile::US11084798, Cpd No 744	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508433&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608967	459093503							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072288	Clc1ccccc1-n1c2cc(C3CC3)c(cc2c(Nc2cncs2)nc1=O)C#N |(1.12,-2.85,;-.22,-3.62,;-.22,-5.16,;-1.55,-5.93,;-2.89,-5.16,;-2.89,-3.62,;-1.55,-2.85,;-1.55,-1.31,;-.22,-.54,;1.12,-1.31,;2.45,-.54,;3.78,-1.31,;4.55,-2.64,;5.32,-1.31,;2.45,1,;1.12,1.77,;-.22,1,;-1.55,1.77,;-1.55,3.31,;-2.89,4.08,;-3.05,5.61,;-4.55,5.93,;-5.32,4.6,;-4.29,3.45,;-2.89,1,;-2.89,-.54,;-4.22,-1.31,;3.78,1.77,;5.12,2.54,)|	InChI=1S/C21H14ClN5OS/c22-16-3-1-2-4-17(16)27-18-8-14(12-5-6-12)13(9-23)7-15(18)20(26-21(27)28)25-19-10-24-11-29-19/h1-4,7-8,10-12H,5-6H2,(H,25,26,28)	FZXMTZUZRWPGAV-UHFFFAOYSA-N	508434	US11130759, Cpd. No. 745::US11046691, Compound 745::1-(2-chlorophenyl)-7-cyclopropyl-2- oxo-4-(thiazol-5-ylamino)-1,2-dihydro- quinazoline-6-carbonitrile::US11084798, Cpd No 745	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508434&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			147599854	459093504							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072289	Cn1nccc1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(cc12)C#N |(-1.9,6.48,;-.75,5.45,;.75,5.77,;1.52,4.44,;.49,3.3,;-.91,3.92,;-2.25,3.15,;-2.25,1.61,;-3.58,.84,;-3.58,-.7,;-4.92,-1.47,;-2.25,-1.47,;-2.25,-3.01,;-.91,-3.78,;-.91,-5.32,;-2.25,-6.09,;-3.58,-5.32,;-3.58,-3.78,;-4.92,-3.01,;-.91,-.7,;.42,-1.47,;1.75,-.7,;3.09,-1.47,;4.63,-1.47,;3.86,-2.8,;1.75,.84,;.42,1.61,;-.91,.84,;3.09,1.61,;4.42,2.38,)|	InChI=1S/C22H17ClN6O/c1-28-20(8-9-25-28)26-21-16-10-14(12-24)15(13-6-7-13)11-19(16)29(22(30)27-21)18-5-3-2-4-17(18)23/h2-5,8-11,13H,6-7H2,1H3,(H,26,27,30)	FOYAKECZVSWRMG-UHFFFAOYSA-N	508435	US11130759, Cpd. No. 746::US11046691, Compound 746::1-(2-chlorophenyl)-7-cyclopropyl-4- ((1-methyl-1H-pyrazol-5-yl)amino)-2- oxo-1,2-dihydroquinazoline-6- carbonitrile::US11084798, Cpd No 746	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508435&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608879	459093505							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072290	Clc1ccccc1-n1c2cc(C3CC3)c(cc2c(NCc2ccno2)nc1=O)C#N |(1.78,-1.93,;.45,-2.69,;.45,-4.23,;-.88,-5,;-2.22,-4.23,;-2.22,-2.69,;-.88,-1.93,;-.88,-.38,;.45,.39,;1.78,-.38,;3.12,.39,;4.45,-.38,;5.22,-1.72,;5.99,-.38,;3.12,1.93,;1.78,2.7,;.45,1.93,;-.88,2.69,;-.88,4.23,;-2.22,5,;-3.55,4.23,;-4.96,4.86,;-5.99,3.72,;-5.22,2.38,;-3.71,2.7,;-2.22,1.93,;-2.22,.38,;-3.55,-.38,;4.45,2.7,;5.78,3.47,)|	InChI=1S/C22H16ClN5O2/c23-18-3-1-2-4-19(18)28-20-10-16(13-5-6-13)14(11-24)9-17(20)21(27-22(28)29)25-12-15-7-8-26-30-15/h1-4,7-10,13H,5-6,12H2,(H,25,27,29)	HKJJVJKKEHHRFN-UHFFFAOYSA-N	508436	US11130759, Cpd. No. 747::US11046691, Compound 747::1-(2-chlorophenyl)-7-cyclopropyl-4- ((isoxazol-5-ylmethyl)amino)-2-oxo- 1,2-dihydroquinazoline-6-carbonitrile::US11084798, Cpd No 747	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508436&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608702	459093506							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072291	Clc1ccccc1-n1c2cc(C3CC3)c(cc2c(NCc2ccon2)nc1=O)C#N |(1.78,-1.93,;.45,-2.69,;.45,-4.23,;-.88,-5,;-2.22,-4.23,;-2.22,-2.69,;-.88,-1.93,;-.88,-.38,;.45,.39,;1.78,-.38,;3.12,.39,;4.45,-.38,;5.22,-1.72,;5.99,-.38,;3.12,1.93,;1.78,2.7,;.45,1.93,;-.88,2.69,;-.88,4.23,;-2.22,5,;-3.55,4.23,;-4.96,4.86,;-5.99,3.72,;-5.22,2.38,;-3.71,2.7,;-2.22,1.93,;-2.22,.38,;-3.55,-.38,;4.45,2.7,;5.78,3.47,)|	InChI=1S/C22H16ClN5O2/c23-18-3-1-2-4-19(18)28-20-10-16(13-5-6-13)14(11-24)9-17(20)21(26-22(28)29)25-12-15-7-8-30-27-15/h1-4,7-10,13H,5-6,12H2,(H,25,26,29)	ZRGUOTJDQRKHGN-UHFFFAOYSA-N	508437	US11130759, Cpd. No. 748::US11046691, Compound 748::1-(2-chlorophenyl)-7-cyclopropyl-4- ((isoxazol-3-ylmethyl)amino)-2-oxo- 1,2-dihydroquinazoline-6-carbonitrile::US11084798, Cpd No 748	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508437&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608991	459093507							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072292	Cn1ccc(CNc2nc(=O)n(-c3ccccc3Cl)c3cc(C4CC4)c(cc23)C#N)n1 |(-5.85,.98,;-5.22,2.38,;-5.99,3.72,;-4.96,4.86,;-3.55,4.23,;-2.22,5,;-.88,4.23,;-.88,2.69,;-2.22,1.93,;-2.22,.38,;-3.55,-.38,;-.88,-.38,;-.88,-1.93,;-2.22,-2.69,;-2.22,-4.23,;-.88,-5,;.45,-4.23,;.45,-2.69,;1.78,-1.93,;.45,.39,;1.78,-.38,;3.12,.39,;4.45,-.38,;5.22,-1.72,;5.99,-.38,;3.12,1.93,;1.78,2.7,;.45,1.93,;4.45,2.7,;5.78,3.47,;-3.71,2.7,)|	InChI=1S/C23H19ClN6O/c1-29-9-8-16(28-29)13-26-22-18-10-15(12-25)17(14-6-7-14)11-21(18)30(23(31)27-22)20-5-3-2-4-19(20)24/h2-5,8-11,14H,6-7,13H2,1H3,(H,26,27,31)	IVKIKAPBSWLVOC-UHFFFAOYSA-N	508438	US11130759, Cpd. No. 749::US11046691, Compound 749::1-(2-chlorophenyl)-7-cyclopropyl-4- (((1-methyl-1H-pyrazol-3- yl)methyl)amino)-2-oxo-1,2- dihydroquinazoline-6-carbonitrile::US11084798, Cpd No 749	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508438&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153609039	459093508							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072293	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(C)cc12 |(-3.44,5,;-2.1,4.23,;-2.1,2.69,;-3.44,1.93,;-3.44,.38,;-4.77,-.38,;-2.1,-.38,;-2.1,-1.93,;-3.44,-2.69,;-3.44,-4.23,;-2.1,-5,;-.77,-4.23,;-.77,-2.69,;.56,-1.93,;-.77,.39,;.56,-.38,;1.9,.39,;3.23,-.38,;4,-1.72,;4.77,-.38,;1.9,1.93,;3.23,2.7,;.56,2.7,;-.77,1.93,)|	InChI=1S/C19H18ClN3O/c1-11-9-14-17(10-13(11)12-7-8-12)23(19(24)22-18(14)21-2)16-6-4-3-5-15(16)20/h3-6,9-10,12H,7-8H2,1-2H3,(H,21,22,24)	CLTHTVHGTNHYDF-UHFFFAOYSA-N	508439	US11130759, Cpd. No. 750::US11046691, Compound 750::1-(2-chlorophenyl)-7-cyclopropyl-6- methyl-4-(methylamino) quinazolin- 2(1H)-one::US11084798, Cpd No 750	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508439&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608483	459093509							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072294	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(c(C)cc12)C(F)(F)F |(-3.33,5,;-2,4.23,;-2,2.69,;-3.33,1.93,;-3.33,.38,;-4.67,-.38,;-2,-.38,;-2,-1.93,;-3.33,-2.69,;-3.33,-4.23,;-2,-5,;-.67,-4.23,;-.67,-2.69,;.67,-1.93,;-.67,.39,;.67,-.38,;2,.39,;2,1.93,;3.33,2.7,;.67,2.7,;-.67,1.93,;3.33,-.38,;4.67,-1.15,;4.1,.95,;2.56,-1.72,)|	InChI=1S/C17H13ClF3N3O/c1-9-7-10-14(8-11(9)17(19,20)21)24(16(25)23-15(10)22-2)13-6-4-3-5-12(13)18/h3-8H,1-2H3,(H,22,23,25)	PZEIYHREONVBAU-UHFFFAOYSA-N	508440	US11130759, Cpd. No. 751::US11046691, Compound 751::1-(2-chlorophenyl)-6-methyl-4- (methylamino)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 751	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508440&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608634	459093510							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072295	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(C3CC3)c(cc12)C(F)F |(-3.44,5,;-2.1,4.23,;-2.1,2.69,;-3.44,1.93,;-3.44,.38,;-4.77,-.38,;-2.1,-.38,;-2.1,-1.93,;-3.44,-2.69,;-3.44,-4.23,;-2.1,-5,;-.77,-4.23,;-.77,-2.69,;.56,-1.93,;-.77,.39,;.56,-.38,;1.9,.39,;3.23,-.38,;4,-1.72,;4.77,-.38,;1.9,1.93,;.56,2.7,;-.77,1.93,;3.23,2.7,;3.23,4.24,;4.56,1.93,)|	InChI=1S/C19H16ClF2N3O/c1-23-18-13-8-12(17(21)22)11(10-6-7-10)9-16(13)25(19(26)24-18)15-5-3-2-4-14(15)20/h2-5,8-10,17H,6-7H2,1H3,(H,23,24,26)	YVQXYXDWYRHUIL-UHFFFAOYSA-N	508441	US11130759, Cpd. No. 752::US11046691, Compound 752::1-(2-chlorophenyl)-7-cyclopropyl-6- (difluoromethyl)-4-(methylamino)- quinazolin-2(1H)-one::US11084798, Cpd No 752	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508441	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508441&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608905	459093511							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072296	CNc1nc(=O)n(-c2ccccc2Cl)c2cc(c(cc12)C(F)F)C(F)(F)F |(-3.33,5,;-2,4.23,;-2,2.69,;-3.33,1.93,;-3.33,.38,;-4.67,-.38,;-2,-.38,;-2,-1.93,;-3.33,-2.69,;-3.33,-4.23,;-2,-5,;-.67,-4.23,;-.67,-2.69,;.67,-1.93,;-.67,.39,;.67,-.38,;2,.39,;2,1.93,;.67,2.7,;-.67,1.93,;3.33,2.7,;3.33,4.24,;4.67,1.93,;3.33,-.38,;4.67,-1.15,;4.1,.95,;2.56,-1.72,)|	InChI=1S/C17H11ClF5N3O/c1-24-15-9-6-8(14(19)20)10(17(21,22)23)7-13(9)26(16(27)25-15)12-5-3-2-4-11(12)18/h2-7,14H,1H3,(H,24,25,27)	WYRZXLPXJLNKAK-UHFFFAOYSA-N	508442	US11130759, Cpd. No. 753::US11046691, Compound 753::1-(2-chlorophenyl)-6-(difluoromethyl)- 4-(methylamino)-7-(trifluoromethyl)- quinazolin-2(1H)-one::US11084798, Cpd No 753	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508442&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608877	459093512							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072297	CNc1nc(=O)n(-c2cccnc2Cl)c2cc(C3CC3)c(Br)cc12 |(-3.44,5.01,;-2.1,4.24,;-2.1,2.7,;-3.44,1.93,;-3.44,.39,;-4.77,-.38,;-2.1,-.38,;-2.1,-1.93,;-3.44,-2.69,;-3.44,-4.23,;-2.1,-5,;-.77,-4.23,;-.77,-2.69,;.56,-1.93,;-.77,.39,;.56,-.38,;1.9,.38,;3.23,-.38,;4,-1.72,;4.77,-.38,;1.9,1.93,;3.23,2.69,;.56,2.69,;-.77,1.93,)|	InChI=1S/C17H14BrClN4O/c1-20-16-11-7-12(18)10(9-4-5-9)8-14(11)23(17(24)22-16)13-3-2-6-21-15(13)19/h2-3,6-9H,4-5H2,1H3,(H,20,22,24)	GGNBEPAQPSZWEF-UHFFFAOYSA-N	508443	US11130759, Cpd. No. 754::US11046691, Compound 754::6-bromo-1-(2-chloropyridin-3-yl)-7- cyclopropyl-4- (methylamino)quinazolin-2(1H)-one::US11084798, Cpd No 754	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508443&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			150285607	459093513							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072298	CNc1nc(=O)n(-c2cccnc2C(F)(F)F)c2cc(C3CC3)c(Br)cc12 |(-3.44,5.01,;-2.1,4.24,;-2.1,2.7,;-3.44,1.93,;-3.44,.39,;-4.77,-.38,;-2.1,-.38,;-2.1,-1.93,;-3.44,-2.69,;-3.44,-4.23,;-2.1,-5,;-.77,-4.23,;-.72,-2.67,;.61,-1.9,;1.94,-1.13,;-.16,-.56,;1.38,-3.23,;-.77,.39,;.56,-.38,;1.9,.38,;3.23,-.38,;4,-1.72,;4.77,-.38,;1.9,1.93,;3.23,2.69,;.56,2.69,;-.77,1.93,)|	InChI=1S/C18H14BrF3N4O/c1-23-16-11-7-12(19)10(9-4-5-9)8-14(11)26(17(27)25-16)13-3-2-6-24-15(13)18(20,21)22/h2-3,6-9H,4-5H2,1H3,(H,23,25,27)	ZIBHBENQAAQVOP-UHFFFAOYSA-N	508444	US11130759, Cpd. No. 755::US11046691, Compound 755::6-bromo-7-cyclopropyl-4-(methyl- amino)-1-(2-(trifluoromethyl)pyridin-3- yl)-quinazolin-2(1H)-one::US11084798, Cpd No 755	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508444&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			152653598	459093514							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072299	CNc1nc(=O)n(-c2ccccc2Br)c2cc(C3CC3)c(cc12)C#N |(-5.44,-.77,;-4.1,,;-2.77,-.77,;-2.77,-2.31,;-1.44,-3.08,;-1.44,-4.62,;-.1,-2.31,;1.23,-3.08,;1.23,-4.62,;2.56,-5.39,;3.9,-4.62,;3.9,-3.08,;2.56,-2.31,;2.56,-.77,;-.1,-.77,;1.23,,;1.23,1.54,;2.56,2.31,;4.1,2.31,;3.33,3.64,;-.1,2.31,;-1.44,1.54,;-1.44,,;-.1,3.85,;-.1,5.39,)|	InChI=1S/C19H15BrN4O/c1-22-18-14-8-12(10-21)13(11-6-7-11)9-17(14)24(19(25)23-18)16-5-3-2-4-15(16)20/h2-5,8-9,11H,6-7H2,1H3,(H,22,23,25)	TZBBATCMMOGUIN-UHFFFAOYSA-N	508445	US11130759, Cpd. No. 757::1-(2-bromophenyl)-7-cyclopropyl-4- (methylamino)-2-oxo-1,2-dihydro- quinazoline-6-carbonitrile, single unknown atropisomer::US11046691, Compound 757::US11046691, Compound 756::US11084798, Cpd No 757	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508445&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608475	459093515							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072300	CNc1nc(=O)n(-c2ccccc2Br)c2cc(C3CC3)c(cc12)C#N |(-5.44,-.77,;-4.1,,;-2.77,-.77,;-2.77,-2.31,;-1.44,-3.08,;-1.44,-4.62,;-.1,-2.31,;1.23,-3.08,;1.23,-4.62,;2.56,-5.39,;3.9,-4.62,;3.9,-3.08,;2.56,-2.31,;2.56,-.77,;-.1,-.77,;1.23,,;1.23,1.54,;2.56,2.31,;4.1,2.31,;3.33,3.64,;-.1,2.31,;-1.44,1.54,;-1.44,,;-.1,3.85,;-.1,5.39,)|	InChI=1S/C19H15BrN4O/c1-22-18-14-8-12(10-21)13(11-6-7-11)9-17(14)24(19(25)23-18)16-5-3-2-4-15(16)20/h2-5,8-9,11H,6-7H2,1H3,(H,22,23,25)	TZBBATCMMOGUIN-UHFFFAOYSA-N	508445	US11130759, Cpd. No. 757::1-(2-bromophenyl)-7-cyclopropyl-4- (methylamino)-2-oxo-1,2-dihydro- quinazoline-6-carbonitrile, single unknown atropisomer::US11046691, Compound 757::US11046691, Compound 756::US11084798, Cpd No 757	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508445&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608475	459093515							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072301	CNc1nc(=O)n(-c2ccccc2C2CC2)c2cc(C3CC3)c(cc12)C#N |(-3.44,5,;-2.1,4.23,;-2.1,2.69,;-3.44,1.93,;-3.44,.38,;-4.77,-.38,;-2.1,-.38,;-2.1,-1.93,;-3.44,-2.69,;-3.44,-4.23,;-2.1,-5,;-.77,-4.23,;-.77,-2.69,;.56,-1.93,;2.1,-1.93,;1.33,-.59,;-.77,.39,;.56,-.38,;1.9,.39,;3.23,-.38,;4,-1.72,;4.77,-.38,;1.9,1.93,;.56,2.7,;-.77,1.93,;3.23,2.7,;4.56,3.47,)|	InChI=1S/C22H20N4O/c1-24-21-18-10-15(12-23)17(14-8-9-14)11-20(18)26(22(27)25-21)19-5-3-2-4-16(19)13-6-7-13/h2-5,10-11,13-14H,6-9H2,1H3,(H,24,25,27)	VRKYZTRFNKFCPA-UHFFFAOYSA-N	508447	US11130759, Cpd. No. 758::US11046691, Compound 758::7-cyclopropyl-1-(2-cyclopropylphenyl)- 4-(methylamino)-2-oxo-1,2-dihydro- quinazoline-6-carbonitrile::US11084798, Cpd No 758	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508447&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608272	459093516							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072302	CNc1nc(=O)n(-c2ccccc2C(F)(F)F)c2cc(C3CC3)c(cc12)C#N |(-5.44,-.77,;-4.1,,;-2.77,-.77,;-2.77,-2.31,;-1.44,-3.08,;-1.44,-4.62,;-.1,-2.31,;1.23,-3.08,;1.23,-4.62,;2.56,-5.39,;3.9,-4.62,;3.9,-3.08,;2.56,-2.25,;2.56,-.71,;2.56,.83,;1.02,-.71,;4.1,-.71,;-.1,-.77,;1.23,,;1.23,1.54,;2.56,2.31,;4.1,2.31,;3.33,3.64,;-.1,2.31,;-1.44,1.54,;-1.44,,;-.1,3.85,;-.1,5.39,)|	InChI=1S/C20H15F3N4O/c1-25-18-14-8-12(10-24)13(11-6-7-11)9-17(14)27(19(28)26-18)16-5-3-2-4-15(16)20(21,22)23/h2-5,8-9,11H,6-7H2,1H3,(H,25,26,28)	STDJCFVBEYXYLJ-UHFFFAOYSA-N	508448	US11130759, Cpd. No. 759::US11046691, Compound 759::7-cyclopropyl-4-(methylamino)-2-oxo- 1-(2-(trifluoromethyl)phenyl)-1,2- dihydro-quinazoline-6-carbonitrile::US11084798, Cpd No 759	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508448&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608812	459093517							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072303	COc1cc(cc2n(-c3ccccc3)c(=O)nc(N[C@@H]3C[C@H]3F)c12)C(F)(F)F |r|	InChI=1S/C19H15F4N3O2/c1-28-15-8-10(19(21,22)23)7-14-16(15)17(24-13-9-12(13)20)25-18(27)26(14)11-5-3-2-4-6-11/h2-8,12-13H,9H2,1H3,(H,24,25,27)	YVFPRZVCQUZGFQ-UHFFFAOYSA-N	508449	US11130759, Cpd. No. 760::US11046691, Compound 760::4-(((1R,2R)-2-fluorocyclopropyl)- amino)-5-methoxy-1-phenyl-7- (trifluoromethyl)quinazolin-2(1H)-one, single unknown enantiomer::US11084798, Cpd No 760	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508449&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			154929283	459093518							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072304	COc1cc(cc2n(-c3ccccc3)c(=O)nc(N[C@H]3C[C@@H]3F)c12)C(F)(F)F |r|	InChI=1S/C19H15F4N3O2/c1-28-15-8-10(19(21,22)23)7-14-16(15)17(24-13-9-12(13)20)25-18(27)26(14)11-5-3-2-4-6-11/h2-8,12-13H,9H2,1H3,(H,24,25,27)	YVFPRZVCQUZGFQ-UHFFFAOYSA-N	508250	US11130759, Cpd. No. 761::US11046691, Compound 761::4-(((trans)-2-fluorocyclopropyl)amino)- 5-methoxy-1-phenyl-7- (trifluoromethyl)-quinazolin-2(1H)-one::US11046691, Compound 561::US11084798, Cpd No 561	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508250&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608856	459093327							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072305	CN(C)S(=O)(=O)CCNc1nc(=O)n(-c2ccccc2Cl)c2nc(Cl)ccc12 |(-8,.77,;-6.67,1.54,;-6.67,3.08,;-5.33,.77,;-6.1,-.56,;-4.56,-.56,;-4,1.54,;-2.67,.77,;-1.33,1.54,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-.77,;4,-1.54,;4,-3.08,;5.33,-3.85,;6.67,-3.08,;6.67,-1.54,;5.33,-.77,;5.33,.77,;2.67,.77,;4,1.54,;4,3.08,;5.33,3.85,;2.67,3.85,;1.33,3.08,;1.33,1.54,)|	InChI=1S/C17H17Cl2N5O3S/c1-23(2)28(26,27)10-9-20-15-11-7-8-14(19)21-16(11)24(17(25)22-15)13-6-4-3-5-12(13)18/h3-8H,9-10H2,1-2H3,(H,20,22,25)	AJSCNUCGYMAOAE-UHFFFAOYSA-N	512426	US11084798, Cpd No 762::2-((1-(2-chlorophenyl)-2-oxo-7- (trifluoromethyl)-1,2- dihydropyrido[2,3-4pyrimidin-4- yl)amino)-N,N- dimethylethanesulfonamide	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=512426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=512426&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162533595	459629672							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072306	CNC(=O)CCNc1nc(=O)n(-c2ccccc2Cl)c2nc(Cl)ccc12 |(-8,.77,;-6.67,1.54,;-5.33,.77,;-5.33,-.77,;-4,1.54,;-2.67,.77,;-1.33,1.54,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-.77,;4,-1.54,;4,-3.08,;5.33,-3.85,;6.67,-3.08,;6.67,-1.54,;5.33,-.77,;5.33,.77,;2.67,.77,;4,1.54,;4,3.08,;5.33,3.85,;2.67,3.85,;1.33,3.08,;1.33,1.54,)|	InChI=1S/C17H15Cl2N5O2/c1-20-14(25)8-9-21-15-10-6-7-13(19)22-16(10)24(17(26)23-15)12-5-3-2-4-11(12)18/h2-7H,8-9H2,1H3,(H,20,25)(H,21,23,26)	KUOHRRJGROGGJR-UHFFFAOYSA-N	512427	US11084798, Cpd No 763::3-((1-(2-chlorophenyl)-2-oxo-7- (trifluoromethyl)-1,2- dihydropyrido[2,3-d]-pyrimidin-4- yl)amino)-N-methylpropanamide	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=512427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=512427&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162533596	459629673							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072307	CN(C)CCNc1nc(=O)n(-c2cccnc2C)c2cc(ccc12)C1CC1 |(-7.44,.87,;-6.1,.1,;-6.1,-1.44,;-4.77,.87,;-3.44,.1,;-2.1,.87,;-.77,.1,;-.77,-1.44,;.56,-2.21,;.56,-3.75,;1.9,-1.44,;3.23,-2.21,;3.23,-3.75,;4.56,-4.52,;5.9,-3.75,;5.9,-2.21,;4.56,-1.44,;4.56,.1,;1.9,.1,;3.23,.87,;3.23,2.41,;1.9,3.18,;.56,2.41,;.56,.87,;4.56,3.18,;6.1,3.18,;5.33,4.52,)|	InChI=1S/C21H25N5O/c1-14-18(5-4-10-22-14)26-19-13-16(15-6-7-15)8-9-17(19)20(24-21(26)27)23-11-12-25(2)3/h4-5,8-10,13,15H,6-7,11-12H2,1-3H3,(H,23,24,27)	UCXACFOWDDJECL-UHFFFAOYSA-N	508453	US11130759, Cpd. No. 764::US11046691, Compound 764::7-cyclopropyl-4((2-(dimethylamino)- ethyl)amino)-1-(2-methylpyridin-3-yl)- quinazolin-2(1H)-one::US11084798, Cpd No 764	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508453&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151982112	459093521							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072308	CNS(=O)(=O)CCNc1nc(=O)n(-c2cccnc2C)c2cc(ccc12)C1CC1 |(-8.11,.1,;-6.77,.87,;-5.44,.1,;-6.21,-1.23,;-4.67,-1.23,;-4.1,.87,;-2.77,.1,;-1.44,.87,;-.1,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-1.44,;3.9,-2.21,;3.9,-3.75,;5.23,-4.52,;6.57,-3.75,;6.57,-2.21,;5.23,-1.44,;5.23,.1,;2.56,.1,;3.9,.87,;3.9,2.41,;2.56,3.18,;1.23,2.41,;1.23,.87,;5.23,3.18,;6.77,3.18,;6,4.52,)|	InChI=1S/C20H23N5O3S/c1-13-17(4-3-9-22-13)25-18-12-15(14-5-6-14)7-8-16(18)19(24-20(25)26)23-10-11-29(27,28)21-2/h3-4,7-9,12,14,21H,5-6,10-11H2,1-2H3,(H,23,24,26)	BRAGDFNXOFGDMX-UHFFFAOYSA-N	508454	US11046691, Compound 765::2-((7-cyclopropyl-1-(2-methylpyridin- 3-yl)-2-oxo-1,2-dihydroquinazolin-4- yl)-amino)-N,N-dimethylethane-1- sulfonamide::US11084798, Cpd No 765	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508454&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			156541988	459093522							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072309	CNC(=O)CCNc1nc(=O)n(-c2cccnc2C)c2cc(ccc12)C1CC1 |(-8.11,.1,;-6.77,.87,;-5.44,.1,;-5.44,-1.44,;-4.1,.87,;-2.77,.1,;-1.44,.87,;-.1,.1,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-1.44,;3.9,-2.21,;3.9,-3.75,;5.23,-4.52,;6.57,-3.75,;6.57,-2.21,;5.23,-1.44,;5.23,.1,;2.56,.1,;3.9,.87,;3.9,2.41,;2.56,3.18,;1.23,2.41,;1.23,.87,;5.23,3.18,;6.77,3.18,;6,4.52,)|	InChI=1S/C21H23N5O2/c1-13-17(4-3-10-23-13)26-18-12-15(14-5-6-14)7-8-16(18)20(25-21(26)28)24-11-9-19(27)22-2/h3-4,7-8,10,12,14H,5-6,9,11H2,1-2H3,(H,22,27)(H,24,25,28)	ARIIHBFOHKRFBD-UHFFFAOYSA-N	508455	US11130759, Cpd. No. 766::US11046691, Compound 766::3-((7-cyclopropyl-1-(2-methylpyridin- 3-yl)-2-oxo-1,2-dihydroquinazolin-4- yl)-amino)-N-methylpropanamide::US11084798, Cpd No 766	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508455&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608874	459093523							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072310	Cc1ncccc1-n1c2cc(ccc2c(NCCCN2CCOCC2)nc1=O)C1CC1 |(6.57,.1,;6.57,-1.44,;7.9,-2.21,;7.9,-3.75,;6.57,-4.52,;5.23,-3.75,;5.23,-2.21,;3.9,-1.44,;3.9,.1,;5.23,.87,;5.23,2.41,;3.9,3.18,;2.56,2.41,;2.56,.87,;1.23,.1,;-.1,.87,;-1.44,.1,;-2.77,.87,;-4.1,.1,;-5.44,.87,;-5.44,2.41,;-6.77,3.18,;-8.11,2.41,;-8.11,.87,;-6.77,.1,;1.23,-1.44,;2.56,-2.21,;2.56,-3.75,;6.57,3.18,;8.11,3.18,;7.34,4.52,)|	InChI=1S/C24H29N5O2/c1-17-21(4-2-9-25-17)29-22-16-19(18-5-6-18)7-8-20(22)23(27-24(29)30)26-10-3-11-28-12-14-31-15-13-28/h2,4,7-9,16,18H,3,5-6,10-15H2,1H3,(H,26,27,30)	SOLBIOSQFQPNSC-UHFFFAOYSA-N	508456	US11130759, Cpd. No. 767::US11046691, Compound 767::7-cyclopropyl-1-(2-methylpyridin-3- yl)-4-((3-morpholinopropyl)amino)- quinazolin-2(1H)-one::US11084798, Cpd No 767	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508456&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151879647	459093524							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072311	CNc1nc(=O)n(-c2cccnc2C(F)(F)F)c2nc(ccc12)C(F)(F)F |(-5.44,.1,;-4.1,.87,;-2.77,.1,;-2.77,-1.44,;-1.44,-2.21,;-1.44,-3.75,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-4.52,;3.9,-3.75,;3.9,-2.21,;2.56,-1.38,;2.56,.16,;2.56,1.7,;1.02,.16,;4.1,.16,;-.1,.1,;1.23,.87,;1.23,2.41,;-.1,3.18,;-1.44,2.41,;-1.44,.87,;2.56,3.18,;3.9,3.95,;3.33,1.85,;1.79,4.52,)|	InChI=1S/C15H9F6N5O/c1-22-11-7-4-5-9(14(16,17)18)24-12(7)26(13(27)25-11)8-3-2-6-23-10(8)15(19,20)21/h2-6H,1H3,(H,22,25,27)	CEYHOIXNULOYPS-UHFFFAOYSA-N	508457	US11130759, Cpd. No. 768::US11046691, Compound 768::4-(methylamino)-7-(trifluoromethyl)-1- (2-(trifluoromethyl)pyridin-3- yl)pyrido[2,3-d]-pyrimidin-2(1H)-one::US11084798, Cpd No 769	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508457&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149889779	459093525							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072312	CNc1nc(=O)n(-c2cccnc2C(F)(F)F)c2nc(ccc12)C(F)(F)F |(-5.44,.1,;-4.1,.87,;-2.77,.1,;-2.77,-1.44,;-1.44,-2.21,;-1.44,-3.75,;-.1,-1.44,;1.23,-2.21,;1.23,-3.75,;2.56,-4.52,;3.9,-3.75,;3.9,-2.21,;2.56,-1.38,;2.56,.16,;2.56,1.7,;1.02,.16,;4.1,.16,;-.1,.1,;1.23,.87,;1.23,2.41,;-.1,3.18,;-1.44,2.41,;-1.44,.87,;2.56,3.18,;3.9,3.95,;3.33,1.85,;1.79,4.52,)|	InChI=1S/C15H9F6N5O/c1-22-11-7-4-5-9(14(16,17)18)24-12(7)26(13(27)25-11)8-3-2-6-23-10(8)15(19,20)21/h2-6H,1H3,(H,22,25,27)	CEYHOIXNULOYPS-UHFFFAOYSA-N	508457	US11130759, Cpd. No. 768::US11046691, Compound 768::4-(methylamino)-7-(trifluoromethyl)-1- (2-(trifluoromethyl)pyridin-3- yl)pyrido[2,3-d]-pyrimidin-2(1H)-one::US11084798, Cpd No 769	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508457&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			149889779	459093525							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072313	F[C@@H]1CC1Nc1nc(=O)n(-c2ccccc2C(F)(F)F)c2nc(ccc12)C(F)(F)F |r,wD:1.0,(-4.03,-2.87,;-4.43,-1.38,;-5.51,-.3,;-4.03,.1,;-2.69,.87,;-1.36,.1,;-1.36,-1.44,;-.03,-2.21,;-.03,-3.75,;1.31,-1.44,;2.64,-2.21,;2.64,-3.75,;3.97,-4.52,;5.31,-3.75,;5.31,-2.21,;4.01,-1.35,;4.02,.19,;4.04,1.73,;2.48,.21,;5.56,.18,;1.31,.1,;2.64,.87,;2.64,2.41,;1.31,3.18,;-.03,2.41,;-.03,.87,;3.97,3.18,;5.31,3.95,;3.2,4.52,;4.74,1.85,)|	InChI=1S/C18H11F7N4O/c19-10-7-11(10)26-14-8-5-6-13(18(23,24)25)27-15(8)29(16(30)28-14)12-4-2-1-3-9(12)17(20,21)22/h1-6,10-11H,7H2,(H,26,28,30)	IDLHCRZYVOLNLS-UHFFFAOYSA-N	512434	US11084798, Cpd No 770::1-(2-chlorophenyl)-4-(((1S,2R)-2- fluorocyclopropyl)amino)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one, single unknown enantiomer	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=512434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=512434&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			162533599	459629680							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072314	F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:1.0,wD:3.4,(-3.92,-2.87,;-4.32,-1.38,;-5.41,-.3,;-3.92,.1,;-2.59,.87,;-1.26,.1,;-1.26,-1.44,;.08,-2.21,;.08,-3.75,;1.41,-1.44,;2.74,-2.21,;2.74,-3.75,;4.08,-4.52,;5.41,-3.75,;5.41,-2.21,;4.08,-1.44,;4.08,.1,;1.41,.1,;2.74,.87,;2.74,2.41,;1.41,3.18,;.08,2.41,;.08,.87,;4.08,3.18,;5.41,3.95,;3.31,4.52,;4.85,1.85,)|	InChI=1S/C17H11ClF4N4O/c18-9-3-1-2-4-12(9)26-15-8(5-6-13(24-15)17(20,21)22)14(25-16(26)27)23-11-7-10(11)19/h1-6,10-11H,7H2,(H,23,25,27)	GYESABLLTMWWPD-UHFFFAOYSA-N	512435	US11130759, Cpd. No. 771::US11084798, Cpd No 771::1-(2-chlorophenyl)-4-(((1R,2S)-2- fluorocyclopropyl)amino)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one, single unknown enantiomer	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=512435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=512435&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608768	459629681							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072315	O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2Br)c2cc(Cl)ccc12 |r,wD:1.0,(-.34,6.43,;.56,5.18,;2.1,5.18,;2.58,3.72,;1.33,2.81,;.09,3.72,;1.33,1.27,;2.67,.5,;2.67,-1.04,;4,-1.81,;1.33,-1.81,;1.33,-3.35,;2.67,-4.12,;2.67,-5.66,;1.33,-6.43,;,-5.66,;,-4.12,;-1.33,-3.35,;,-1.04,;-1.33,-1.81,;-2.67,-1.04,;-4,-1.81,;-2.67,.5,;-1.33,1.27,;,.5,)|	InChI=1S/C18H15BrClN3O2/c19-14-3-1-2-4-15(14)23-16-9-11(20)5-6-13(16)17(21-18(23)25)22-8-7-12(24)10-22/h1-6,9,12,24H,7-8,10H2	RMGYURSMJZAIHE-UHFFFAOYSA-N	507791	US11130759, Cpd. No. 772::US11046691, Compound 87::4-((3R)-3-hydroxypyrrolidin-1-yl)-1-(2- bromophenyl)-7- chlorohydroquinazolin-2-one::US11084798, Cpd No 88	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=507791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=507791&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			151739753	459092876							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072316	CNc1nc(=O)n(Cc2c[nH]cn2)c2cc(ccc12)C1CC1	InChI=1S/C16H17N5O/c1-17-15-13-5-4-11(10-2-3-10)6-14(13)21(16(22)20-15)8-12-7-18-9-19-12/h4-7,9-10H,2-3,8H2,1H3,(H,18,19)(H,17,20,22)	MRNRDYMTJRSTFB-UHFFFAOYSA-N	508462	US11130759, Cpd. No. 773::US11046691, Compound 773::1-((1H-imidazol-4-yl)methyl)-7- cyclopropyl-4-(methylamino) quinazolin-2(1H)-one::US11084798, Cpd No 773	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508462&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608229	459093530							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072317	CNc1nc(=O)n([C@@H](C)c2c[nH]cn2)c2cc(ccc12)C(F)(F)F |r|	InChI=1S/C15H14F3N5O/c1-8(11-6-20-7-21-11)23-12-5-9(15(16,17)18)3-4-10(12)13(19-2)22-14(23)24/h3-8H,1-2H3,(H,20,21)(H,19,22,24)	LQRYQAIZKALPOC-UHFFFAOYSA-N	508463	US11130759, Cpd. No. 774::US11046691, Compound 774::(S)-1-(1-(1H-imidazol-4-yl)ethyl)-4- (methylamino)-7-(trifluoromethyl)- quinazolin-2(1H)-one, Single unknown enantiomer::US11084798, Cpd No 774	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508463&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608910	459093531							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072318	CNc1nc(=O)n([C@H](C)c2c[nH]cn2)c2cc(ccc12)C(F)(F)F |r|	InChI=1S/C15H14F3N5O/c1-8(11-6-20-7-21-11)23-12-5-9(15(16,17)18)3-4-10(12)13(19-2)22-14(23)24/h3-8H,1-2H3,(H,20,21)(H,19,22,24)	LQRYQAIZKALPOC-UHFFFAOYSA-N	508464	US11130759, Cpd. No. 775::US11046691, Compound 775::(R)-1-(1-(1H-imidazol-4-yl)ethyl)-4- (methylamino)-7- (trifluoromethyl)quinazolin-2(1H)-one, single unknown enantiomer::US11084798, Cpd No 775	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508464&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608509	459093532							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1072319	CNc1nc(=O)n(Cc2c[nH]cn2)c2cc(ccc12)C(F)(F)F	InChI=1S/C14H12F3N5O/c1-18-12-10-3-2-8(14(15,16)17)4-11(10)22(13(23)21-12)6-9-5-19-7-20-9/h2-5,7H,6H2,1H3,(H,19,20)(H,18,21,23)	SSGYRIZJXAVYRX-UHFFFAOYSA-N	508465	US11130759, Cpd. No. 776::US11046691, Compound 776::1-(2-chlorophenyl)-7-cyclopropyl-4- (methylamino)-6-(methylthio)- quinazolin-2(1H)-one::US11084798, Cpd No 776	S-adenosylmethionine synthase isoform type-2	Homo sapiens		<200							US Patent		10.7270/Q2PN98RZ		aid1805790	US11084798	Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE	8/10/2021	1/23/2022	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=508465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=508465&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search			153608958	459093533							1	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY	9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM	S-adenosylmethionine synthase isoform type-2	METK2_HUMAN	P31153	A8K511 B4DN45 D6W5L1 Q53SP5