BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1090387 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C25H21ClFN3O3S/c1-25(12-13-34(32,33)15-25)28-24(31)16-6-11-20-22(14-16)30(18-9-7-17(27)8-10-18)29-23(20)19-4-2-3-5-21(19)26/h2-11,14H,12-13,15H2,1H3,(H,28,31) JIFSWAJPIBLONL-UHFFFAOYSA-N 517167 US11104690, Example 1-A Diacylglycerol O-acyltransferase 2 Homo sapiens 4.50 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517167 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517167&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678325 461603208 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090388 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C24H19ClFN3O3S/c25-21-4-2-1-3-19(21)23-20-10-5-15(24(30)27-17-11-12-33(31,32)14-17)13-22(20)29(28-23)18-8-6-16(26)7-9-18/h1-10,13,17H,11-12,14H2,(H,27,30) IFTCYJWQHGBPGR-UHFFFAOYSA-N 517168 US11104690, Example 2-A Diacylglycerol O-acyltransferase 2 Homo sapiens 12.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517168 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517168&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678326 461603209 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090389 C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C25H21ClFN3O3S/c1-25(12-13-34(32,33)15-25)28-24(31)16-6-11-20-22(14-16)30(18-9-7-17(27)8-10-18)29-23(20)19-4-2-3-5-21(19)26/h2-11,14H,12-13,15H2,1H3,(H,28,31) JIFSWAJPIBLONL-UHFFFAOYSA-N 517169 US11104690, Example 1-B::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(3-methyl-1,1- dioxidotetrahydrothiophen-3-yl)- 1H-indazole-6-carboxamide (Enantiomer B) Diacylglycerol O-acyltransferase 2 Homo sapiens 8.30 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517169 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517169&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678327 461603210 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090390 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1 |r| InChI=1S/C24H19ClFN3O3S/c25-21-4-2-1-3-19(21)23-20-10-5-15(24(30)27-17-11-12-33(31,32)14-17)13-22(20)29(28-23)18-8-6-16(26)7-9-18/h1-10,13,17H,11-12,14H2,(H,27,30) IFTCYJWQHGBPGR-UHFFFAOYSA-N 517170 US11104690, Example 2-B::3-(2-chlorophenyl)-N-(1,1- dioxidotetrahydrothiophen-3-yl)- 1-(4-fluorophenyl)-1H-indazole- 6-carboxamide (Enantiomer B) Diacylglycerol O-acyltransferase 2 Homo sapiens 303 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517170 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517170&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678328 461603211 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090391 C[C@@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1ccc([n+]([O-])c1)C(F)(F)F |r| InChI=1S/C28H19ClF4N4O2/c1-16(18-7-13-25(28(31,32)33)36(39)15-18)34-27(38)17-6-12-22-24(14-17)37(20-10-8-19(30)9-11-20)35-26(22)21-4-2-3-5-23(21)29/h2-16H,1H3,(H,34,38) AVCGASKYALCWNB-UHFFFAOYSA-N 517172 US11104690, Example 3::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-{(1R)-1-[1- oxido-6-(trifluoromethyl)pyridin- 3-yl]ethyl}-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 155 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517172&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220209 461603213 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090392 C[C@@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1cnc(nc1)C(F)(F)F |r| InChI=1S/C27H18ClF4N5O/c1-15(17-13-33-26(34-14-17)27(30,31)32)35-25(38)16-6-11-21-23(12-16)37(19-9-7-18(29)8-10-19)36-24(21)20-4-2-3-5-22(20)28/h2-15H,1H3,(H,35,38) ONNSYWJFONSNCL-UHFFFAOYSA-N 517173 US11104690, Example 4::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-{(1R)-1-[2- (trifluoromethyl)pyrimidin-5- yl]ethyl}-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 67.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517173 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517173&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220188 461603214 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090393 OC[C@@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1ccc(nc1)C(F)(F)F |r| InChI=1S/C28H19ClF4N4O2/c29-22-4-2-1-3-20(22)26-21-11-5-16(13-24(21)37(36-26)19-9-7-18(30)8-10-19)27(39)35-23(15-38)17-6-12-25(34-14-17)28(31,32)33/h1-14,23,38H,15H2,(H,35,39) NXLFGBLFRUYQHC-UHFFFAOYSA-N 517174 US11104690, Example 5::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-{(1S)-2- hydroxy-1-[6- (trifluoromethyl)pyridin-3- yl]ethyl}-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 45.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517174&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522110 461603215 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090394 CN1CCC(NC(=O)c2ccc3c(nn(-c4ccc(F)cc4)c3c2)-c2ccccc2Cl)C1=O InChI=1S/C25H20ClFN4O2/c1-30-13-12-21(25(30)33)28-24(32)15-6-11-19-22(14-15)31(17-9-7-16(27)8-10-17)29-23(19)18-4-2-3-5-20(18)26/h2-11,14,21H,12-13H2,1H3,(H,28,32) MCDBVFGXXHEQJP-UHFFFAOYSA-N 517178 US11104690, Example 6::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(1-methyl-2- oxopyrrolidin-3-yl)-1H-indazole- 6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 686 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517178 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517178&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522975 461603219 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090395 CC(NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1cn(cn1)C(=O)OC(C)(C)C InChI=1S/C30H27ClFN5O3/c1-18(25-16-36(17-33-25)29(39)40-30(2,3)4)34-28(38)19-9-14-23-26(15-19)37(21-12-10-20(32)11-13-21)35-27(23)22-7-5-6-8-24(22)31/h5-18H,1-4H3,(H,34,38) VALOLBOVOFJSBX-UHFFFAOYSA-N 517179 US11104690, Example 7::tert-butyl 4-[1-({[3-(2- chlorophenyl)-1-(4- fluorophenyl)-1H-indazol-6- yl]carbonyl}amino)ethyl]-1H- imidazole-1-carboxylate (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 164 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517179&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522858 461603220 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090396 N[C@H]1CS(=O)(=O)C[C@@H]1NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C24H20ClFN4O3S/c25-19-4-2-1-3-17(19)23-18-10-5-14(24(31)28-21-13-34(32,33)12-20(21)27)11-22(18)30(29-23)16-8-6-15(26)7-9-16/h1-11,20-21H,12-13,27H2,(H,28,31) DBVJRFGARBBDQU-UHFFFAOYSA-N 517180 US11104690, Example 8::N-[(3R,4R)-4-amino-1,1- dioxidotetrahydrothiophen-3-yl]- 3-(2-chlorophenyl)-1-(4- fluorophenyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 554 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517180&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522482 461603221 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090397 O[C@@H]1CS(=O)(=O)C[C@H]1NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C24H19ClFN3O4S/c25-19-4-2-1-3-17(19)23-18-10-5-14(24(31)27-20-12-34(32,33)13-22(20)30)11-21(18)29(28-23)16-8-6-15(26)7-9-16/h1-11,20,22,30H,12-13H2,(H,27,31) WPLXDLHGBKXFLR-UHFFFAOYSA-N 517181 US11104690, Example 9::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(3S,4S)-4- hydroxy-1,1- dioxidotetrahydrothiophen-3-yl]- 1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 531 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517181&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220204 461603222 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090398 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)Nc1ccc(nc1)C(F)(F)F InChI=1S/C26H15ClF4N4O/c27-21-4-2-1-3-19(21)24-20-11-5-15(13-22(20)35(34-24)18-9-6-16(28)7-10-18)25(36)33-17-8-12-23(32-14-17)26(29,30)31/h1-14H,(H,33,36) GHCDISMHZQFCQQ-UHFFFAOYSA-N 517182 US11104690, Example 10::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[6- (trifluoromethyl)pyridin-3-yl]- 1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 608 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517182&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522113 461603223 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090399 C[C@@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1ccc(nc1)C(F)(F)F |r| InChI=1S/C28H19ClF4N4O/c1-16(18-7-13-25(34-15-18)28(31,32)33)35-27(38)17-6-12-22-24(14-17)37(20-10-8-19(30)9-11-20)36-26(22)21-4-2-3-5-23(21)29/h2-16H,1H3,(H,35,38) MHAIAZMUAJUQLE-UHFFFAOYSA-N 517183 US11104690, Example 11::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-{(1R)-1-[6- (trifluoromethyl)pyridin-3- yl]ethyl}-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 38.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517183&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134523520 461603224 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090400 COC[C@H](C)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C24H21ClFN3O2/c1-15(14-31-2)27-24(30)16-7-12-20-22(13-16)29(18-10-8-17(26)9-11-18)28-23(20)19-5-3-4-6-21(19)25/h3-13,15H,14H2,1-2H3,(H,27,30) HTPNPBVTLHZFSU-UHFFFAOYSA-N 517184 US11104690, Example 12::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S)-2- methoxy-1-methylethyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 85.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517184&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522613 461603225 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090401 C[C@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1ccc(nc1)C(F)(F)F |r| InChI=1S/C28H19ClF4N4O/c1-16(18-7-13-25(34-15-18)28(31,32)33)35-27(38)17-6-12-22-24(14-17)37(20-10-8-19(30)9-11-20)36-26(22)21-4-2-3-5-23(21)29/h2-16H,1H3,(H,35,38) MHAIAZMUAJUQLE-UHFFFAOYSA-N 517185 US11104690, Example 13::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-{(1S)-1-[6- (trifluoromethyl)pyridin-3- yl]ethyl}-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 48.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517185&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522978 461603226 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090402 CC(NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1c[nH]cn1 InChI=1S/C25H19ClFN5O/c1-15(22-13-28-14-29-22)30-25(33)16-6-11-20-23(12-16)32(18-9-7-17(27)8-10-18)31-24(20)19-4-2-3-5-21(19)26/h2-15H,1H3,(H,28,29)(H,30,33) OZKOHQFEZREGMZ-UHFFFAOYSA-N 517186 US11104690, Example 14::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[1-(1H- imidazol-4-yl)ethyl]-1H-indazole- 6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 78.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517186&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522104 461603227 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090403 CC(C)(C)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C24H21ClFN3O/c1-24(2,3)27-23(30)15-8-13-19-21(14-15)29(17-11-9-16(26)10-12-17)28-22(19)18-6-4-5-7-20(18)25/h4-14H,1-3H3,(H,27,30) GZKQGJPIXSPAFZ-UHFFFAOYSA-N 517187 US11104690, Example 15::N-tert-butyl-3-(2-chlorophenyl)- 1-(4-fluorophenyl)-1H-indazole- 6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 77.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517187&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 142354431 461603228 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090404 Cn1cc(cn1)C(C)(C)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C27H23ClFN5O/c1-27(2,18-15-30-33(3)16-18)31-26(35)17-8-13-22-24(14-17)34(20-11-9-19(29)10-12-20)32-25(22)21-6-4-5-7-23(21)28/h4-16H,1-3H3,(H,31,35) OBTLICBCPYFGNU-UHFFFAOYSA-N 517188 US11104690, Example 16::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[1-methyl-1-(1- methyl-1H-pyrazol-4-yl)ethyl]- 1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 120 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517188&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522898 461603229 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090405 CC(NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1c(C)n[nH]c1C InChI=1S/C27H23ClFN5O/c1-15(25-16(2)31-32-17(25)3)30-27(35)18-8-13-22-24(14-18)34(20-11-9-19(29)10-12-20)33-26(22)21-6-4-5-7-23(21)28/h4-15H,1-3H3,(H,30,35)(H,31,32) KZONCETYRYSSPO-UHFFFAOYSA-N 517189 US11104690, Example 17::3-(2-chlorophenyl)-N-[1-(3,5- dimethyl-1H-pyrazol-4-yl)ethyl]- 1-(4-fluorophenyl)-1H-indazole- 6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 83.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517189&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522807 461603230 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090406 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCc1ccc(nc1)C(F)(F)F InChI=1S/C27H17ClF4N4O/c28-22-4-2-1-3-20(22)25-21-11-6-17(13-23(21)36(35-25)19-9-7-18(29)8-10-19)26(37)34-15-16-5-12-24(33-14-16)27(30,31)32/h1-14H,15H2,(H,34,37) YQDHZUWVGKQQGY-UHFFFAOYSA-N 517190 US11104690, Example 18::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-{[6- (trifluoromethyl)pyridin-3- yl]methyl}-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 64.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517190&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 142354440 461603231 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090407 CC(C)(C)OC(=O)CCNC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C27H25ClFN3O3/c1-27(2,3)35-24(33)14-15-30-26(34)17-8-13-21-23(16-17)32(19-11-9-18(29)10-12-19)31-25(21)20-6-4-5-7-22(20)28/h4-13,16H,14-15H2,1-3H3,(H,30,34) WCHZETLLPCMELH-UHFFFAOYSA-N 517191 US11104690, Example 19::tert-butyl N-{[3-(2- chlorophenyl)-1-(4- fluorophenyl)-1H-indazol-6- yl]carbonyl}-beta-alaninate Diacylglycerol O-acyltransferase 2 Homo sapiens 585 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517191&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 142354439 461603232 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090408 NS(=O)(=O)CCNC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C22H18ClFN4O3S/c23-19-4-2-1-3-17(19)21-18-10-5-14(22(29)26-11-12-32(25,30)31)13-20(18)28(27-21)16-8-6-15(24)7-9-16/h1-10,13H,11-12H2,(H,26,29)(H2,25,30,31) YCFMIVNQCDCPNF-UHFFFAOYSA-N 517192 US11104690, Example 20::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(2- sulfamoylethyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 148 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517192&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522732 461603233 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090409 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1COC1 InChI=1S/C23H17ClFN3O2/c24-20-4-2-1-3-18(20)22-19-10-5-14(23(29)26-16-12-30-13-16)11-21(19)28(27-22)17-8-6-15(25)7-9-17/h1-11,16H,12-13H2,(H,26,29) WRWWIBRHHZPZEE-UHFFFAOYSA-N 517193 US11104690, Example 21::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-oxetan-3-yl-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 873 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517193&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522059 461603234 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090410 CN1CC(CC1=O)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C25H20ClFN4O2/c1-30-14-17(13-23(30)32)28-25(33)15-6-11-20-22(12-15)31(18-9-7-16(27)8-10-18)29-24(20)19-4-2-3-5-21(19)26/h2-12,17H,13-14H2,1H3,(H,28,33) ZUDAILDJDCCLGW-UHFFFAOYSA-N 517194 US11104690, Example 22::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(1-methyl-5- oxopyrrolidin-3-yl)-1H-indazole- 6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 102 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517194&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522553 461603235 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090411 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N1CC2CC1CS(=O)(=O)C2 InChI=1S/C26H21ClFN3O3S/c27-23-4-2-1-3-21(23)25-22-10-5-17(12-24(22)31(29-25)19-8-6-18(28)7-9-19)26(32)30-13-16-11-20(30)15-35(33,34)14-16/h1-10,12,16,20H,11,13-15H2 PYFKNDZBJPPSIX-UHFFFAOYSA-N 517196 US11104690, Example 23::3-(2-chlorophenyl)-6-[(3,3- dioxido-3-thia-6- azabicyclo[3.2.1]oct-6- yl)carbonyl]-1-(4-fluorophenyl)- 1H-indazole (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 403 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517196&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522528 461603237 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090412 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)CC1 InChI=1S/C25H21ClFN3O3S/c26-22-4-2-1-3-20(22)24-21-10-5-16(25(31)28-18-11-13-34(32,33)14-12-18)15-23(21)30(29-24)19-8-6-17(27)7-9-19/h1-10,15,18H,11-14H2,(H,28,31) XSLKOTQFOUADLX-UHFFFAOYSA-N 517197 US11104690, Example 24::3-(2-chlorophenyl)-N-(1,1- dioxidotetrahydro-2H-thiopyran- 4-yl)-1-(4-fluorophenyl)-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 61.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517197 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517197&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522880 461603238 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090413 CN(C)S(=O)(=O)CCNC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C24H22ClFN4O3S/c1-29(2)34(32,33)14-13-27-24(31)16-7-12-20-22(15-16)30(18-10-8-17(26)9-11-18)28-23(20)19-5-3-4-6-21(19)25/h3-12,15H,13-14H2,1-2H3,(H,27,31) AZZPIOUSFZCVSM-UHFFFAOYSA-N 517198 US11104690, Example 25::3-(2-chlorophenyl)-N-[2- (dimethylsulfamoyl)ethyl]-1-(4- fluorophenyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 558 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517198 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517198&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 142354451 461603239 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090414 CCS(=O)(=O)CCNC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C24H21ClFN3O3S/c1-2-33(31,32)14-13-27-24(30)16-7-12-20-22(15-16)29(18-10-8-17(26)9-11-18)28-23(20)19-5-3-4-6-21(19)25/h3-12,15H,2,13-14H2,1H3,(H,27,30) RORZKYLORXWEGA-UHFFFAOYSA-N 517199 US11104690, Example 26::3-(2-chlorophenyl)-N-[2- (ethylsulfonyl)ethyl]-1-(4- ftuorophenyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 446 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517199 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517199&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522795 461603240 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090415 CC(N(C)C(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1cc([nH]n1)-c1ccccc1 InChI=1S/C32H25ClFN5O/c1-20(28-19-29(36-35-28)21-8-4-3-5-9-21)38(2)32(40)22-12-17-26-30(18-22)39(24-15-13-23(34)14-16-24)37-31(26)25-10-6-7-11-27(25)33/h3-20H,1-2H3,(H,35,36) NMRQXZDVXUHBNG-UHFFFAOYSA-N 517200 US11104690, Example 27::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-methyl-N-[1-(5- phenyl-1H-pyrazol-3-yl)ethyl]- 1H-indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 301 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517200 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517200&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678333 461603241 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090416 CC(C)(NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1ccc(nc1)C(F)(F)F InChI=1S/C29H21ClF4N4O/c1-28(2,18-8-14-25(35-16-18)29(32,33)34)36-27(39)17-7-13-22-24(15-17)38(20-11-9-19(31)10-12-20)37-26(22)21-5-3-4-6-23(21)30/h3-16H,1-2H3,(H,36,39) VZGAHTDOGIWOBW-UHFFFAOYSA-N 517201 US11104690, Example 28::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-{1-methyl-1-[6- (trifluoromethyl)pyridin-3- yl]ethyl}-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 93.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517201 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517201&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 142354434 461603242 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090417 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCC1CCS(=O)(=O)C1 InChI=1S/C25H21ClFN3O3S/c26-22-4-2-1-3-20(22)24-21-10-5-17(25(31)28-14-16-11-12-34(32,33)15-16)13-23(21)30(29-24)19-8-6-18(27)7-9-19/h1-10,13,16H,11-12,14-15H2,(H,28,31) MVUZVUTWAFLOGV-UHFFFAOYSA-N 517202 US11104690, Example 29::3-(2-chlorophenyl)-N-[(1,1- dioxidotetrahydrothiophen-3- yl)methyl]-1-(4-fluorophenyl)- 1H-indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 65.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517202 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517202&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522515 461603243 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090418 OC[C@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1ccc(nc1)C(F)(F)F |r| InChI=1S/C28H19ClF4N4O2/c29-22-4-2-1-3-20(22)26-21-11-5-16(13-24(21)37(36-26)19-9-7-18(30)8-10-19)27(39)35-23(15-38)17-6-12-25(34-14-17)28(31,32)33/h1-14,23,38H,15H2,(H,35,39) NXLFGBLFRUYQHC-UHFFFAOYSA-N 517203 US11104690, Example 30::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-{(1R)-2- hydroxy-1-[6- (trifluoromethyl)pyridin-3- yl]ethyl}-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 48.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517203 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517203&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522537 461603244 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090419 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCc1cccnc1 InChI=1S/C26H18ClFN4O/c27-23-6-2-1-5-21(23)25-22-12-7-18(26(33)30-16-17-4-3-13-29-15-17)14-24(22)32(31-25)20-10-8-19(28)9-11-20/h1-15H,16H2,(H,30,33) WLENMOJGBQBHRO-UHFFFAOYSA-N 517204 US11104690, Example 31::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(pyridin-3- ylmethyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 320 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517204 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517204&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522873 461603245 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090420 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCc1ccccn1 InChI=1S/C26H18ClFN4O/c27-23-7-2-1-6-21(23)25-22-13-8-17(26(33)30-16-19-5-3-4-14-29-19)15-24(22)32(31-25)20-11-9-18(28)10-12-20/h1-15H,16H2,(H,30,33) MHWAPMGKMFYZIG-UHFFFAOYSA-N 517205 US11104690, Example 32::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(pyridin-2- ylmethyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 495 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517205 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517205&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522066 461603246 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090421 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCc1ccncc1 InChI=1S/C26H18ClFN4O/c27-23-4-2-1-3-21(23)25-22-10-5-18(26(33)30-16-17-11-13-29-14-12-17)15-24(22)32(31-25)20-8-6-19(28)7-9-20/h1-15H,16H2,(H,30,33) LBTXEEXPGCBAIM-UHFFFAOYSA-N 517206 US11104690, Example 33::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(pyridin-4- ylmethyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 654 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517206 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517206&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522639 461603247 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090422 C[C@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1cnc(C)nc1 |r| InChI=1S/C27H21ClFN5O/c1-16(19-14-30-17(2)31-15-19)32-27(35)18-7-12-23-25(13-18)34(21-10-8-20(29)9-11-21)33-26(23)22-5-3-4-6-24(22)28/h3-16H,1-2H3,(H,32,35) UATLWZPBFHUFFO-UHFFFAOYSA-N 517207 US11104690, Example 34::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S)-1-(2- methylpyrimidin-5-yl)ethyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 75.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517207 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517207&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522572 461603248 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090423 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCc1cn2cccnc2n1 InChI=1S/C27H18ClFN6O/c28-23-5-2-1-4-21(23)25-22-11-6-17(14-24(22)35(33-25)20-9-7-18(29)8-10-20)26(36)31-15-19-16-34-13-3-12-30-27(34)32-19/h1-14,16H,15H2,(H,31,36) GRCNYDZCHMDIEI-UHFFFAOYSA-N 517208 US11104690, Example 35::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(imidazo[1,2- a]pyrimidin-2-ylmethyl)-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 415 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517208 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517208&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522824 461603249 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090424 CC(NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1nncn1C InChI=1S/C25H20ClFN6O/c1-15(24-30-28-14-32(24)2)29-25(34)16-7-12-20-22(13-16)33(18-10-8-17(27)9-11-18)31-23(20)19-5-3-4-6-21(19)26/h3-15H,1-2H3,(H,29,34) KDMJVZPFSCKJHJ-UHFFFAOYSA-N 517209 US11104690, Example 36::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[1-(4-methyl- 4H-1,2,4-triazol-3-yl)ethyl]-1H- indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 889 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517209 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517209&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522607 461603250 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090425 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCc1cnoc1 InChI=1S/C24H16ClFN4O2/c25-21-4-2-1-3-19(21)23-20-10-5-16(24(31)27-12-15-13-28-32-14-15)11-22(20)30(29-23)18-8-6-17(26)7-9-18/h1-11,13-14H,12H2,(H,27,31) AVRCLHVFFQEBPY-UHFFFAOYSA-N 517210 US11104690, Example 37::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(isoxazol-4- ylmethyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 221 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517210 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517210&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522131 461603251 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090426 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCc1cncnc1 InChI=1S/C25H17ClFN5O/c26-22-4-2-1-3-20(22)24-21-10-5-17(25(33)30-14-16-12-28-15-29-13-16)11-23(21)32(31-24)19-8-6-18(27)7-9-19/h1-13,15H,14H2,(H,30,33) OLWRXIQBQMXVST-UHFFFAOYSA-N 517211 US11104690, Example 38::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(pyrimidin-5- ylmethyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 368 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517211 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517211&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522833 461603252 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090427 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCCn1cnnc1 InChI=1S/C24H18ClFN6O/c25-21-4-2-1-3-19(21)23-20-10-5-16(24(33)27-11-12-31-14-28-29-15-31)13-22(20)32(30-23)18-8-6-17(26)7-9-18/h1-10,13-15H,11-12H2,(H,27,33) NYAGXMSTGUCZOO-UHFFFAOYSA-N 517212 US11104690, Example 39::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[2-(4H-1,2,4- triazol-4-yl)ethyl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 96.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517212 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517212&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522474 461603253 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090428 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCc1cnsn1 InChI=1S/C23H15ClFN5OS/c24-20-4-2-1-3-18(20)22-19-10-5-14(23(31)26-12-16-13-27-32-29-16)11-21(19)30(28-22)17-8-6-15(25)7-9-17/h1-11,13H,12H2,(H,26,31) CMDKQFAAXJYWIE-UHFFFAOYSA-N 517213 US11104690, Example 40::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(1,2,5- thiadiazol-3-ylmethyl)-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 445 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517213 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517213&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522042 461603254 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090429 CC(NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1noc(C)n1 InChI=1S/C25H19ClFN5O2/c1-14(24-29-15(2)34-31-24)28-25(33)16-7-12-20-22(13-16)32(18-10-8-17(27)9-11-18)30-23(20)19-5-3-4-6-21(19)26/h3-14H,1-2H3,(H,28,33) MKOGKQAMAFFLPW-UHFFFAOYSA-N 517214 US11104690, Example 41::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[1-(5-methyl- 1,2,4-oxadiazol-3-yl)ethyl]-1H- indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 519 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517214 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517214&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522052 461603255 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090430 CC(C)(CO)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C24H21ClFN3O2/c1-24(2,14-30)27-23(31)15-7-12-19-21(13-15)29(17-10-8-16(26)9-11-17)28-22(19)18-5-3-4-6-20(18)25/h3-13,30H,14H2,1-2H3,(H,27,31) HJHQKMCAMDYDNE-UHFFFAOYSA-N 517215 US11104690, Example 42::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(2-hydroxy-1,1- dimethylethyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 26.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517215 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517215&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522888 461603256 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090431 OCC1(CCCC1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C26H23ClFN3O2/c27-22-6-2-1-5-20(22)24-21-12-7-17(25(33)29-26(16-32)13-3-4-14-26)15-23(21)31(30-24)19-10-8-18(28)9-11-19/h1-2,5-12,15,32H,3-4,13-14,16H2,(H,29,33) IMHPFEGSFFVKFC-UHFFFAOYSA-N 517216 US11104690, Example 43::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[1- (hydroxymethyl)cyclopentyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 11.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517216 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517216&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134523060 461603257 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090432 OC1(CNC(=O)c2ccc3c(nn(-c4ccc(F)cc4)c3c2)-c2ccccc2Cl)CCCCC1 InChI=1S/C27H25ClFN3O2/c28-23-7-3-2-6-21(23)25-22-13-8-18(26(33)30-17-27(34)14-4-1-5-15-27)16-24(22)32(31-25)20-11-9-19(29)10-12-20/h2-3,6-13,16,34H,1,4-5,14-15,17H2,(H,30,33) CZJLQLVYHHQSMQ-UHFFFAOYSA-N 517217 US11104690, Example 44::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1- hydroxycyclohexyl)methyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 176 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517217&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522856 461603258 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090433 COCCNC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C23H19ClFN3O2/c1-30-13-12-26-23(29)15-6-11-19-21(14-15)28(17-9-7-16(25)8-10-17)27-22(19)18-4-2-3-5-20(18)24/h2-11,14H,12-13H2,1H3,(H,26,29) XSZVJJFKPXZLRS-UHFFFAOYSA-N 517218 US11104690, Example 45::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(2- methoxyethyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 424 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517218 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517218&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522153 461603259 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090434 CC(CO)(CO)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C24H21ClFN3O3/c1-24(13-30,14-31)27-23(32)15-6-11-19-21(12-15)29(17-9-7-16(26)8-10-17)28-22(19)18-4-2-3-5-20(18)25/h2-12,30-31H,13-14H2,1H3,(H,27,32) XDQCOAIQZQDMOP-UHFFFAOYSA-N 517219 US11104690, Example 46::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[2-hydroxy-1- (hydroxymethyl)-1-methylethyl]- 1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 49.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517219 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517219&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522136 461603260 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090435 OCC1(CCOCC1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C26H23ClFN3O3/c27-22-4-2-1-3-20(22)24-21-10-5-17(25(33)29-26(16-32)11-13-34-14-12-26)15-23(21)31(30-24)19-8-6-18(28)7-9-19/h1-10,15,32H,11-14,16H2,(H,29,33) NKLWVVJGBRUJTR-UHFFFAOYSA-N 517220 US11104690, Example 47::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[4- (hydroxymethyl)tetrahydro-2H- pyran-4-yl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 47.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517220 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517220&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522109 461603261 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090436 C[C@@H](O)[C@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1nc(C)no1 |r| InChI=1S/C26H21ClFN5O3/c1-14(34)23(26-29-15(2)32-36-26)30-25(35)16-7-12-20-22(13-16)33(18-10-8-17(28)9-11-18)31-24(20)19-5-3-4-6-21(19)27/h3-14,23,34H,1-2H3,(H,30,35) PYYGTMHBAZNWPW-UHFFFAOYSA-N 517221 US11104690, Example 48::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1R,2S)-2- hydroxy-1-(3-methyl-1,2,4- oxadiazol-5-yl)propyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 96.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517221 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517221&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146230469 461603262 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090437 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCc1cnc(nc1)C(F)(F)F InChI=1S/C26H16ClF4N5O/c27-21-4-2-1-3-19(21)23-20-10-5-16(11-22(20)36(35-23)18-8-6-17(28)7-9-18)24(37)32-12-15-13-33-25(34-14-15)26(29,30)31/h1-11,13-14H,12H2,(H,32,37) QMZZSICLUMVALU-UHFFFAOYSA-N 517222 US11104690, Example 49::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-{[2- (trifluoromethyl)pyrimidin-5- yl]methyl}-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 79.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517222 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517222&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522587 461603263 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090438 C[C@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1cnc(nc1)C(F)(F)F |r| InChI=1S/C27H18ClF4N5O/c1-15(17-13-33-26(34-14-17)27(30,31)32)35-25(38)16-6-11-21-23(12-16)37(19-9-7-18(29)8-10-19)36-24(21)20-4-2-3-5-22(20)28/h2-15H,1H3,(H,35,38) ONNSYWJFONSNCL-UHFFFAOYSA-N 517223 US11104690, Example 50::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-{(1S)-1-[2- (trifluoromethyl)pyrimidin-5- yl]ethyl}-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 34.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517223 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517223&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522589 461603264 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090439 C[C@H](CS(N)(=O)=O)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C23H20ClFN4O3S/c1-14(13-33(26,31)32)27-23(30)15-6-11-19-21(12-15)29(17-9-7-16(25)8-10-17)28-22(19)18-4-2-3-5-20(18)24/h2-12,14H,13H2,1H3,(H,27,30)(H2,26,31,32) IHLUMLSKESFFBQ-UHFFFAOYSA-N 517224 US11104690, Example 51::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1R)-1-methyl- 2-sulfamoylethyl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 184 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517224 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517224&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522609 461603265 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090440 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CCNC1=O InChI=1S/C24H18ClFN4O2/c25-19-4-2-1-3-17(19)22-18-10-5-14(23(31)28-20-11-12-27-24(20)32)13-21(18)30(29-22)16-8-6-15(26)7-9-16/h1-10,13,20H,11-12H2,(H,27,32)(H,28,31) JSYKDXJJRYARSA-UHFFFAOYSA-N 517225 US11104690, Example 52::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(2- oxopyrrolidin-3-yl)-1H-indazole- 6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 413 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517225 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517225&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522134 461603266 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090441 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCCS(=O)(=O)NC1CCCCC1 InChI=1S/C28H28ClFN4O3S/c29-25-9-5-4-8-23(25)27-24-15-10-19(18-26(24)34(32-27)22-13-11-20(30)12-14-22)28(35)31-16-17-38(36,37)33-21-6-2-1-3-7-21/h4-5,8-15,18,21,33H,1-3,6-7,16-17H2,(H,31,35) AHLQEYDKHLLLIK-UHFFFAOYSA-N 517226 US11104690, Example 53::3-(2-chlorophenyl)-N-[2- (cyclohexylsulfamoyl)ethyl]-1-(4- fluorophenyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 32.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517226 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517226&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134523056 461603267 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090442 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCCS(=O)(=O)NCc1ccccc1 InChI=1S/C29H24ClFN4O3S/c30-26-9-5-4-8-24(26)28-25-15-10-21(18-27(25)35(34-28)23-13-11-22(31)12-14-23)29(36)32-16-17-39(37,38)33-19-20-6-2-1-3-7-20/h1-15,18,33H,16-17,19H2,(H,32,36) DJIAWPGMWFKRBF-UHFFFAOYSA-N 517227 US11104690, Example 54::N-[2-(benzylsulfamoyl)ethyl]-3- (2-chlorophenyl)-1-(4- fluorophenyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 121 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517227 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517227&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522297 461603268 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090443 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCCS(=O)(=O)Nc1ccccn1 InChI=1S/C27H21ClFN5O3S/c28-23-6-2-1-5-21(23)26-22-13-8-18(17-24(22)34(32-26)20-11-9-19(29)10-12-20)27(35)31-15-16-38(36,37)33-25-7-3-4-14-30-25/h1-14,17H,15-16H2,(H,30,33)(H,31,35) FFOVYRRKGQVBLQ-UHFFFAOYSA-N 517228 US11104690, Example 55::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[2-(pyridin-2- ylsulfamoyl)ethyl]-1H-indazole- 6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 383 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517228 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517228&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522475 461603269 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090444 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCCS(=O)(=O)Nc1ccccc1 InChI=1S/C28H22ClFN4O3S/c29-25-9-5-4-8-23(25)27-24-15-10-19(18-26(24)34(32-27)22-13-11-20(30)12-14-22)28(35)31-16-17-38(36,37)33-21-6-2-1-3-7-21/h1-15,18,33H,16-17H2,(H,31,35) NCICWTSOSRBMPB-UHFFFAOYSA-N 517229 US11104690, Example 56::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[2- (phenylsulfamoyl)ethyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 22.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517229 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517229&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134523255 461603270 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090445 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CC(=O)NC1=O InChI=1S/C24H16ClFN4O3/c25-18-4-2-1-3-16(18)22-17-10-5-13(23(32)27-19-12-21(31)28-24(19)33)11-20(17)30(29-22)15-8-6-14(26)7-9-15/h1-11,19H,12H2,(H,27,32)(H,28,31,33) VPKJQZHSZNSWSA-UHFFFAOYSA-N 517230 US11104690, Example 57::3-(2-chlorophenyl)-N-(2,5- dioxopyrrolidin-3-yl)-1-(4- fluorophenyl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 669 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517230 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517230&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522663 461603271 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090446 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)C1 |r| InChI=1S/C24H19ClFN3O2S/c25-21-4-2-1-3-19(21)23-20-10-5-15(24(30)27-17-11-12-32(31)14-17)13-22(20)29(28-23)18-8-6-16(26)7-9-18/h1-10,13,17H,11-12,14H2,(H,27,30) QHJWOGHGQWBBPP-UHFFFAOYSA-N 517231 US11104690, Example 58-A::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(1- oxidotetrahydrothiophen-3-yl)- 1H-indazole-6-carboxamide (a single diastereomer) Diacylglycerol O-acyltransferase 2 Homo sapiens 668 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517231 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517231&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678334 461603272 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090447 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)C1 |r| InChI=1S/C24H19ClFN3O2S/c25-21-4-2-1-3-19(21)23-20-10-5-15(24(30)27-17-11-12-32(31)14-17)13-22(20)29(28-23)18-8-6-16(26)7-9-18/h1-10,13,17H,11-12,14H2,(H,27,30) QHJWOGHGQWBBPP-UHFFFAOYSA-N 517232 US11104690, Example 58-B::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(1- oxidotetrahydrothiophen-3-yl)- 1H-indazole-6-carboxamide (a single diastereomer) Diacylglycerol O-acyltransferase 2 Homo sapiens 608 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517232 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517232&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678335 461603273 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090448 OCC(=O)C1(CCSC1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C26H21ClFN3O3S/c27-21-4-2-1-3-19(21)24-20-10-5-16(25(34)29-26(23(33)14-32)11-12-35-15-26)13-22(20)31(30-24)18-8-6-17(28)7-9-18/h1-10,13,32H,11-12,14-15H2,(H,29,34) SSMNMARCODZSER-UHFFFAOYSA-N 517233 US11104690, Example 59::methyl 3-({[3-(2-chlorophenyl)- 1-(4-fluorophenyl)-1H-indazol-6- yl]carbonyl}amino)tetra- hydrothiophene-3-carboxylate (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 461 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517233 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517233&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678336 461603274 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090449 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NCCS(=O)(=O)Nc1cccnc1 InChI=1S/C27H21ClFN5O3S/c28-24-6-2-1-5-22(24)26-23-12-7-18(16-25(23)34(32-26)21-10-8-19(29)9-11-21)27(35)31-14-15-38(36,37)33-20-4-3-13-30-17-20/h1-13,16-17,33H,14-15H2,(H,31,35) XAACTKNPOUVMEC-UHFFFAOYSA-N 517234 US11104690, Example 60::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[2-(pyridin-3- ylsulfamoyl)ethyl]-1H-indazole- 6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 16.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517234 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517234&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522051 461603275 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090450 OCC1(CC1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C24H19ClFN3O2/c25-20-4-2-1-3-18(20)22-19-10-5-15(23(31)27-24(14-30)11-12-24)13-21(19)29(28-22)17-8-6-16(26)7-9-17/h1-10,13,30H,11-12,14H2,(H,27,31) DCVSPHXHTWDALG-UHFFFAOYSA-N 517235 US11104690, Example 61::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[1- (hydroxymethyl)cyclopropyl]- 1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 73.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517235&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522606 461603276 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090451 CCOC(=O)C1(CC1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C26H21ClFN3O3/c1-2-34-25(33)26(13-14-26)29-24(32)16-7-12-20-22(15-16)31(18-10-8-17(28)9-11-18)30-23(20)19-5-3-4-6-21(19)27/h3-12,15H,2,13-14H2,1H3,(H,29,32) HFDSCNFMHXNRDH-UHFFFAOYSA-N 517236 US11104690, Example 62::ethyl 1-({[3-(2-chlorophenyl)-1- (4-fluorophenyl)-1H-indazol-6- yl]carbonyl}amino)cyclopropane carboxylate Diacylglycerol O-acyltransferase 2 Homo sapiens 580 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517236 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517236&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522913 461603277 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090452 COC(=O)C1(CCCC1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C27H23ClFN3O3/c1-35-26(34)27(14-4-5-15-27)30-25(33)17-8-13-21-23(16-17)32(19-11-9-18(29)10-12-19)31-24(21)20-6-2-3-7-22(20)28/h2-3,6-13,16H,4-5,14-15H2,1H3,(H,30,33) JYMVEPJMPDYEIA-UHFFFAOYSA-N 517237 US11104690, Example 63::methyl 1-({[3-(2-chlorophenyl)- 1-(4-fluorophenyl)-1H-indazol-6- yl]carbonyl}amino)cyclopentane- carboxylate Diacylglycerol O-acyltransferase 2 Homo sapiens 405 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517237 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517237&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134523039 461603278 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090453 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CCC(F)(F)C1 InChI=1S/C25H19ClF3N3O/c26-21-4-2-1-3-19(21)23-20-10-5-15(24(33)30-17-11-12-25(28,29)14-17)13-22(20)32(31-23)18-8-6-16(27)7-9-18/h1-10,13,17H,11-12,14H2,(H,30,33) BBFSJSUYOANEJF-UHFFFAOYSA-N 517238 US11104690, Example 64::3-(2-chlorophenyl)-N-(3,3- difluorocyclopentyl)-1-(4- fluorophenyl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 132 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517238 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517238&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522116 461603279 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090454 CCC(CO)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C24H21ClFN3O2/c1-2-17(14-30)27-24(31)15-7-12-20-22(13-15)29(18-10-8-16(26)9-11-18)28-23(20)19-5-3-4-6-21(19)25/h3-13,17,30H,2,14H2,1H3,(H,27,31) WEFMHENNKAJEMB-UHFFFAOYSA-N 517239 US11104690, Example 65::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[1- (hydroxyinethyl)propyl]-1H- indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 170 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517239 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517239&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522650 461603280 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090455 O[C@H]1CCCC[C@H]1NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C26H23ClFN3O2/c27-21-6-2-1-5-19(21)25-20-14-9-16(26(33)29-22-7-3-4-8-24(22)32)15-23(20)31(30-25)18-12-10-17(28)11-13-18/h1-2,5-6,9-15,22,24,32H,3-4,7-8H2,(H,29,33) IWIYPUZIAGPHKH-UHFFFAOYSA-N 517240 US11104690, Example 66::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-2- hydroxycyclohexyl]-1H-indazole- 6-carboxamide (cis, racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 68.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517240 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517240&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146230539 461603281 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090456 O[C@@H]1CCCC[C@H]1NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C26H23ClFN3O2/c27-21-6-2-1-5-19(21)25-20-14-9-16(26(33)29-22-7-3-4-8-24(22)32)15-23(20)31(30-25)18-12-10-17(28)11-13-18/h1-2,5-6,9-15,22,24,32H,3-4,7-8H2,(H,29,33) IWIYPUZIAGPHKH-UHFFFAOYSA-N 517241 US11104690, Example 67::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-2- hydroxycyclohexyl]-1H-indazole- 6-carboxamide (trans, racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 40.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517241 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517241&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146230558 461603282 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090457 C[C@@H](CO)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C23H19ClFN3O2/c1-14(13-29)26-23(30)15-6-11-19-21(12-15)28(17-9-7-16(25)8-10-17)27-22(19)18-4-2-3-5-20(18)24/h2-12,14,29H,13H2,1H3,(H,26,30) OYYOEXNYHFTCBP-UHFFFAOYSA-N 517242 US11104690, Example 68::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S)-2- hydroxy-1-methylethyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 310 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517242 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517242&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134523045 461603283 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090458 CC(C)[C@@H](CO)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C25H23ClFN3O2/c1-15(2)22(14-31)28-25(32)16-7-12-20-23(13-16)30(18-10-8-17(27)9-11-18)29-24(20)19-5-3-4-6-21(19)26/h3-13,15,22,31H,14H2,1-2H3,(H,28,32) DUPVYISYNVJFAV-UHFFFAOYSA-N 517243 US11104690, Example 69::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S)-1- (hydroxymethyl)-2- methylpropyl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 8.00 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517243&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522543 461603284 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090459 CC(C)(O)C1(CCOCC1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C28H27ClFN3O3/c1-27(2,35)28(13-15-36-16-14-28)31-26(34)18-7-12-22-24(17-18)33(20-10-8-19(30)9-11-20)32-25(22)21-5-3-4-6-23(21)29/h3-12,17,35H,13-16H2,1-2H3,(H,31,34) HROARXLLVHOWHL-UHFFFAOYSA-N 517244 US11104690, Example 70::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[4-(1-hydroxy-1- methylethyl)tetrahydro-2H-pyran- 4-yl]-1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 607 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517244&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522540 461603285 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090460 O[C@@H]1COc2ccccc2[C@@H]1NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C29H21ClFN3O3/c30-23-7-3-1-5-20(23)27-21-14-9-17(15-24(21)34(33-27)19-12-10-18(31)11-13-19)29(36)32-28-22-6-2-4-8-26(22)37-16-25(28)35/h1-15,25,28,35H,16H2,(H,32,36) XBSWANVTTHJAJT-UHFFFAOYSA-N 517245 US11104690, Example 71::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(3S,4S)-3- hydroxy-3,4-dihydro-2H- chromen-4-yl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 526 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517245 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517245&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220194 461603286 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090461 C[C@@H]1CC[C@@H](O)[C@H]1NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C26H23ClFN3O2/c1-15-6-13-23(32)24(15)29-26(33)16-7-12-20-22(14-16)31(18-10-8-17(28)9-11-18)30-25(20)19-4-2-3-5-21(19)27/h2-5,7-12,14-15,23-24,32H,6,13H2,1H3,(H,29,33) JWKSXTTXAYKCTH-UHFFFAOYSA-N 517246 US11104690, Example 72::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S,2R,5R)-2- hydroxy-5-methylcyclopentyl]- 1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 22.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517246 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517246&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220198 461603287 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090462 CCCCC(NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)C(O)C(F)(F)F InChI=1S/C27H24ClF4N3O2/c1-2-3-8-22(25(36)27(30,31)32)33-26(37)16-9-14-20-23(15-16)35(18-12-10-17(29)11-13-18)34-24(20)19-6-4-5-7-21(19)28/h4-7,9-15,22,25,36H,2-3,8H2,1H3,(H,33,37) AFZDSWYXAHLHGL-UHFFFAOYSA-N 517247 US11104690, Example 73::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[1-(2,2,2- trifluoro-1-hydroxyethyl)pentyl]- 1H-indazole-6-carboxamide (one diastereomer) Diacylglycerol O-acyltransferase 2 Homo sapiens 534 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517247&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522886 461603288 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090463 COC[C@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)[C@@H](O)c1ccccc1 |r| InChI=1S/C30H25ClFN3O3/c1-38-18-26(29(36)19-7-3-2-4-8-19)33-30(37)20-11-16-24-27(17-20)35(22-14-12-21(32)13-15-22)34-28(24)23-9-5-6-10-25(23)31/h2-17,26,29,36H,18H2,1H3,(H,33,37) XLIFNOAGNQUFBX-UHFFFAOYSA-N 517248 US11104690, Example 74::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S,2S)-2- hydroxy-1-(methoxymethyl)-2- phenylethyl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 16.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517248 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517248&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220189 461603289 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090464 OCC1(CCc2ccccc12)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C30H23ClFN3O2/c31-26-8-4-2-6-23(26)28-24-14-9-20(17-27(24)35(34-28)22-12-10-21(32)11-13-22)29(37)33-30(18-36)16-15-19-5-1-3-7-25(19)30/h1-14,17,36H,15-16,18H2,(H,33,37) DHBBMSXBHLZAEY-UHFFFAOYSA-N 517249 US11104690, Example 75::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[1- (hydroxymethyl)-2,3-dihydro-1H- inden-1-yl]-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 357 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517249 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517249&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522098 461603290 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090465 CC(C)(C)OC(=O)N1C[C@@H](O)[C@@H](C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C29H28ClFN4O4/c1-29(2,3)39-28(38)34-15-23(25(36)16-34)32-27(37)17-8-13-21-24(14-17)35(19-11-9-18(31)10-12-19)33-26(21)20-6-4-5-7-22(20)30/h4-14,23,25,36H,15-16H2,1-3H3,(H,32,37) VNBOJBFXSURHRL-UHFFFAOYSA-N 517250 US11104690, Example 76::tert-butyl (3R,4R)-3-({[3-(2- chlorophenyl)-1-(4- fluorophenyl)-1H-indazol-6- yl]carbonyl}amino)-4- hydroxypyrrolidine-1-carboxylate Diacylglycerol O-acyltransferase 2 Homo sapiens 205 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517250 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517250&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146230548 461603291 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090466 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CCOC1 InChI=1S/C24H19ClFN3O2/c25-21-4-2-1-3-19(21)23-20-10-5-15(24(30)27-17-11-12-31-14-17)13-22(20)29(28-23)18-8-6-16(26)7-9-18/h1-10,13,17H,11-12,14H2,(H,27,30) ZDSFICODFSGWOR-UHFFFAOYSA-N 517251 US11104690, Example 77::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N- (tetrahydrofuran-3-yl)-1H- indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 59.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517251 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517251&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522800 461603292 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090467 OCC(NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)C1CC1 InChI=1S/C25H21ClFN3O2/c26-21-4-2-1-3-19(21)24-20-12-7-16(25(32)28-22(14-31)15-5-6-15)13-23(20)30(29-24)18-10-8-17(27)9-11-18/h1-4,7-13,15,22,31H,5-6,14H2,(H,28,32) FESYBIMZWZFWFG-UHFFFAOYSA-N 517252 US11104690, Example 78::3-(2-chlorophenyl)-N-(1- cyclopropyl-2-hydroxyethyl)-1 (4-fluorophenyl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 353 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517252 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517252&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522647 461603293 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090468 C[C@H](CO)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C23H19ClFN3O2/c1-14(13-29)26-23(30)15-6-11-19-21(12-15)28(17-9-7-16(25)8-10-17)27-22(19)18-4-2-3-5-20(18)24/h2-12,14,29H,13H2,1H3,(H,26,30) OYYOEXNYHFTCBP-UHFFFAOYSA-N 517253 US11104690, Example 79::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1R)- hydroxy-1-methylethyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 772 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517253 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517253&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220208 461603294 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090469 OC[C@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)[C@@H](O)c1ccccc1 |r| InChI=1S/C29H23ClFN3O3/c30-24-9-5-4-8-22(24)27-23-15-10-19(16-26(23)34(33-27)21-13-11-20(31)12-14-21)29(37)32-25(17-35)28(36)18-6-2-1-3-7-18/h1-16,25,28,35-36H,17H2,(H,32,37) WAKJJYUFDKAGKA-UHFFFAOYSA-N 517254 US11104690, Example 80::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S,2S)-2- hydroxy-1-(hydroxymethyl)-2- phenylethyl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 127 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517254 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517254&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220192 461603295 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090470 CC(NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)C(O)C(F)(F)F InChI=1S/C24H18ClF4N3O2/c1-13(22(33)24(27,28)29)30-23(34)14-6-11-18-20(12-14)32(16-9-7-15(26)8-10-16)31-21(18)17-4-2-3-5-19(17)25/h2-13,22,33H,1H3,(H,30,34) CSASAUOBCBTLHH-UHFFFAOYSA-N 517255 US11104690, Example 81::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(3,3,3-trifluoro- 2-hydroxy-1-methylpropyl)-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 88.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517255&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522349 461603296 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090471 OC[C@@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1ccccc1 |r| InChI=1S/C28H21ClFN3O2/c29-24-9-5-4-8-22(24)27-23-15-10-19(28(35)31-25(17-34)18-6-2-1-3-7-18)16-26(23)33(32-27)21-13-11-20(30)12-14-21/h1-16,25,34H,17H2,(H,31,35) ZJOLIZIWXRBNCC-UHFFFAOYSA-N 517256 US11104690, Example 82::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S)-2- hydroxy-1-phenylethyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 36.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517256 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517256&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220206 461603297 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090472 OC1CCC(C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C25H21ClFN3O2/c26-22-4-2-1-3-20(22)24-21-12-5-15(25(32)28-17-8-11-19(31)14-17)13-23(21)30(29-24)18-9-6-16(27)7-10-18/h1-7,9-10,12-13,17,19,31H,8,11,14H2,(H,28,32) YIHNUNWNZXBXDQ-UHFFFAOYSA-N 517257 US11104690, Example 83::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(3- hydroxycyclopentyl)-1H- indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 276 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517257 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517257&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522646 461603298 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090473 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CCCC1 InChI=1S/C25H21ClFN3O/c26-22-8-4-3-7-20(22)24-21-14-9-16(25(31)28-18-5-1-2-6-18)15-23(21)30(29-24)19-12-10-17(27)11-13-19/h3-4,7-15,18H,1-2,5-6H2,(H,28,31) ZYCYKDVXQZXIRJ-UHFFFAOYSA-N 517258 US11104690, Example 84::3-(2-chlorophenyl)-N- cyclopentyl-1-(4-fluorophenyl)- 1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 156 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517258 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517258&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522649 461603299 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090474 OCC(CO)(CO)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C24H21ClFN3O4/c25-20-4-2-1-3-18(20)22-19-10-5-15(23(33)27-24(12-30,13-31)14-32)11-21(19)29(28-22)17-8-6-16(26)7-9-17/h1-11,30-32H,12-14H2,(H,27,33) HGFZAVZHQAIJQK-UHFFFAOYSA-N 517259 US11104690, Example 85::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[2-hydroxy-1,1- bis(hydroxymethyl)ethyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 432 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517259 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517259&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522586 461603300 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090475 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CCOCC1 InChI=1S/C25H21ClFN3O2/c26-22-4-2-1-3-20(22)24-21-10-5-16(25(31)28-18-11-13-32-14-12-18)15-23(21)30(29-24)19-8-6-17(27)7-9-19/h1-10,15,18H,11-14H2,(H,28,31) DMIFRWVSDPBKEQ-UHFFFAOYSA-N 517260 US11104690, Example 86::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(tetrahydro-2H- pyran-4-yl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 505 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517260 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517260&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522043 461603301 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090476 OC[C@H]1C[C@@H](NC(=O)c2ccc3c(nn(-c4ccc(F)cc4)c3c2)-c2ccccc2Cl)[C@H](O)[C@@H]1O |r| InChI=1S/C26H23ClFN3O4/c27-20-4-2-1-3-18(20)23-19-10-5-14(26(35)29-21-11-15(13-32)24(33)25(21)34)12-22(19)31(30-23)17-8-6-16(28)7-9-17/h1-10,12,15,21,24-25,32-34H,11,13H2,(H,29,35) WSEYUGGCUNSEQV-UHFFFAOYSA-N 517261 US11104690, Example 87::3-(2-chlorophenyl)-N- [(1R,2S,3R,4R)-2,3-dihydroxy-4- (hydroxymethyl)cyclopentyl]-1- (4-fluorophenyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 198 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517261 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517261&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220210 461603302 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090477 OCC1(CCC1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C25H21ClFN3O2/c26-21-5-2-1-4-19(21)23-20-11-6-16(24(32)28-25(15-31)12-3-13-25)14-22(20)30(29-23)18-9-7-17(27)8-10-18/h1-2,4-11,14,31H,3,12-13,15H2,(H,28,32) KFRZELCFLDVTGY-UHFFFAOYSA-N 517262 US11104690, Example 88::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[1- (hydroxymethyl)cyclobutyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 15.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517262 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517262&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522494 461603303 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090478 COC(=O)C1(CCS(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C26H21ClFN3O4S/c1-35-25(33)26(12-13-36(34)15-26)29-24(32)16-6-11-20-22(14-16)31(18-9-7-17(28)8-10-18)30-23(20)19-4-2-3-5-21(19)27/h2-11,14H,12-13,15H2,1H3,(H,29,32) ORAMFNJRMGEDDE-UHFFFAOYSA-N 517263 US11104690, Example 89::methyl 3-({[3-(2-chlorophenyl)- 1-(4-fluorophenyl)-1H-indazol-6- yl]carbonyl}amino)tetra- hydrothiophene-3-carboxylate 1- oxide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 125 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517263 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517263&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522045 461603304 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090479 COC(=O)C1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C26H21ClFN3O5S/c1-36-25(33)26(12-13-37(34,35)15-26)29-24(32)16-6-11-20-22(14-16)31(18-9-7-17(28)8-10-18)30-23(20)19-4-2-3-5-21(19)27/h2-11,14H,12-13,15H2,1H3,(H,29,32) CFATULYWZWNETJ-UHFFFAOYSA-N 517264 US11104690, Example 90::methyl 3-({[3-(2-chlorophenyl)- 1-(4-fluorophenyl)-1H-indazol-6- yl]carbonyl}amino)tetra- hydrothiophene-3-carboxylate 1,1-dioxide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 90.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517264 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517264&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522150 461603305 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090480 CC(C)(C)OC(=O)N1CCS(=O)(=O)CC(C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C30H30ClFN4O5S/c1-30(2,3)41-29(38)35-14-15-42(39,40)18-21(17-35)33-28(37)19-8-13-24-26(16-19)36(22-11-9-20(32)10-12-22)34-27(24)23-6-4-5-7-25(23)31/h4-13,16,21H,14-15,17-18H2,1-3H3,(H,33,37) AHIXSNMWCQKTMS-UHFFFAOYSA-N 517265 US11104690, Example 91::tert-butyl 6-({[3-(2- chlorophenyl)-1-(4- fluorophenyl)-1H-indazol-6- yl]carbonyl}amino)-1,4- thiazepane-4-carboxylate 1,1- dioxide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 572 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517265 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517265&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134523257 461603306 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090481 OCC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C25H21ClFN3O4S/c26-21-4-2-1-3-19(21)23-20-10-5-16(24(32)28-25(14-31)11-12-35(33,34)15-25)13-22(20)30(29-23)18-8-6-17(27)7-9-18/h1-10,13,31H,11-12,14-15H2,(H,28,32) PYVPQAXOEARNQC-UHFFFAOYSA-N 517266 US11104690, Example 92::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[3- (hydroxymethyl)-1,1- dioxidotetrahydrothiophen-3-yl]- 1H-indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 372 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517266 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517266&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522571 461603307 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090482 OC[C@H](CCCS)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C25H23ClFN3O2S/c26-22-6-2-1-5-20(22)24-21-12-7-16(25(32)28-18(15-31)4-3-13-33)14-23(21)30(29-24)19-10-8-17(27)9-11-19/h1-2,5-12,14,18,31,33H,3-4,13,15H2,(H,28,32) IJILNULXBJPPRZ-UHFFFAOYSA-N 517267 US11104690, Example 93::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S)-1- (hydroxymethyl)-3- (methylsulfanyl)propyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 503 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517267 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517267&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 153447173 461603308 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090483 O[C@@H]1CCC[C@H]1NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C25H21ClFN3O2/c26-20-5-2-1-4-18(20)24-19-13-8-15(25(32)28-21-6-3-7-23(21)31)14-22(19)30(29-24)17-11-9-16(27)10-12-17/h1-2,4-5,8-14,21,23,31H,3,6-7H2,(H,28,32) DQZNKQWAVMGUIN-UHFFFAOYSA-N 517268 US11104690, Example 94::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1R,2R)-2- hydroxycyclopentyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 772 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517268 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517268&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220193 461603309 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090484 CC(C)[C@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)C(N)=O |r| InChI=1S/C25H22ClFN4O2/c1-14(2)22(24(28)32)29-25(33)15-7-12-19-21(13-15)31(17-10-8-16(27)9-11-17)30-23(19)18-5-3-4-6-20(18)26/h3-14,22H,1-2H3,(H2,28,32)(H,29,33) DJAJMZKSTOWNGX-UHFFFAOYSA-N 517269 US11104690, Example 95::N-[(1S)-1-carbamoyl-2- methylpropyl]-3-(2- chlorophenyl)-1-(4- fluorophenyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 606 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517269 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517269&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220199 461603310 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090485 O[C@@H]1CCC[C@@H]1NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C25H21ClFN3O2/c26-20-5-2-1-4-18(20)24-19-13-8-15(25(32)28-21-6-3-7-23(21)31)14-22(19)30(29-24)17-11-9-16(27)10-12-17/h1-2,4-5,8-14,21,23,31H,3,6-7H2,(H,28,32) DQZNKQWAVMGUIN-UHFFFAOYSA-N 517270 US11104690, Example 96::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S,2R)-2- hydroxycyclopentyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 43.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517270 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517270&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146220196 461603311 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090486 O[C@H]1CCC[C@@H]1NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C25H21ClFN3O2/c26-20-5-2-1-4-18(20)24-19-13-8-15(25(32)28-21-6-3-7-23(21)31)14-22(19)30(29-24)17-11-9-16(27)10-12-17/h1-2,4-5,8-14,21,23,31H,3,6-7H2,(H,28,32) DQZNKQWAVMGUIN-UHFFFAOYSA-N 517272 US11104690, Example 97::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S,2S)-2- hydroxycyclopentyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 155 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517272 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517272&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134523141 461603313 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090487 OCC1(CCSC1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C25H21ClFN3O2S/c26-21-4-2-1-3-19(21)23-20-10-5-16(24(32)28-25(14-31)11-12-33-15-25)13-22(20)30(29-23)18-8-6-17(27)7-9-18/h1-10,13,31H,11-12,14-15H2,(H,28,32) CHYMTBONAVOAFY-UHFFFAOYSA-N 517273 US11104690, Example 98::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[3- (hydroxymethyl)tetrahydrothiophen- 3-yl]-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 45.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517273 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517273&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522556 461603314 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090488 CC(C)(C)[C@@H](CO)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C26H25ClFN3O2/c1-26(2,3)23(15-32)29-25(33)16-8-13-20-22(14-16)31(18-11-9-17(28)10-12-18)30-24(20)19-6-4-5-7-21(19)27/h4-14,23,32H,15H2,1-3H3,(H,29,33) OQIZMLKSBKOUMM-UHFFFAOYSA-N 517274 US11104690, Example 99::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S)-1- (hydroxymethyl)-2,2- dimethylpropyl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 6.10 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517274 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517274&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522495 461603315 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090489 CC(C)(C)OC(=O)N1CC[C@@H](C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C29H28ClFN4O3/c1-29(2,3)38-28(37)34-15-14-20(17-34)32-27(36)18-8-13-23-25(16-18)35(21-11-9-19(31)10-12-21)33-26(23)22-6-4-5-7-24(22)30/h4-13,16,20H,14-15,17H2,1-3H3,(H,32,36) QWUFVCIGYZDHCD-UHFFFAOYSA-N 517275 US11104690, Example 100::tert-butyl (3S)-3-({[3-(2- chlorophenyl)-1-(4- fluorophenyl)-1H-indazol-6- yl]carbonyl}amino)pyrrolidine-1- carboxylate Diacylglycerol O-acyltransferase 2 Homo sapiens 12.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517275 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517275&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 142354442 461603316 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090490 CC(C)(C)OC(=O)N1CC[C@H](C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C29H28ClFN4O3/c1-29(2,3)38-28(37)34-15-14-20(17-34)32-27(36)18-8-13-23-25(16-18)35(21-11-9-19(31)10-12-21)33-26(23)22-6-4-5-7-24(22)30/h4-13,16,20H,14-15,17H2,1-3H3,(H,32,36) QWUFVCIGYZDHCD-UHFFFAOYSA-N 517276 US11104690, Example 101::tert-butyl (3R)-3-({[3-(2- chlorophenyl)-1-(4- fluorophenyl)-1H-indazol-6- yl]carbonyl}amino)pyrrolidine-1- carboxylate Diacylglycerol O-acyltransferase 2 Homo sapiens 136 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517276 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517276&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 142354454 461603317 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090491 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CNCCS(=O)(=O)C1 InChI=1S/C25H22ClFN4O3S/c26-22-4-2-1-3-20(22)24-21-10-5-16(25(32)29-18-14-28-11-12-35(33,34)15-18)13-23(21)31(30-24)19-8-6-17(27)7-9-19/h1-10,13,18,28H,11-12,14-15H2,(H,29,32) WIKRMVJHUPLJFL-UHFFFAOYSA-N 517277 US11104690, Example 102::3-(2-chlorophenyl)-N-(1,1- dioxido-1,4-thiazepan-6-yl)-1-(4- fluorophenyl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 179 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517277 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517277&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522894 461603318 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090492 CC[C@H](C)[C@@H](CO)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C26H25ClFN3O2/c1-3-16(2)23(15-32)29-26(33)17-8-13-21-24(14-17)31(19-11-9-18(28)10-12-19)30-25(21)20-6-4-5-7-22(20)27/h4-14,16,23,32H,3,15H2,1-2H3,(H,29,33) WYWYBQBJVNPLPM-UHFFFAOYSA-N 517278 US11104690, Example 103::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1S,2S)-1- (hydroxymethyl)-2-methylbutyl]- 1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 31.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517278&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522563 461603319 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090493 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CC(=O)C1 InChI=1S/C24H17ClFN3O2/c25-21-4-2-1-3-19(21)23-20-10-5-14(24(31)27-16-12-18(30)13-16)11-22(20)29(28-23)17-8-6-15(26)7-9-17/h1-11,16H,12-13H2,(H,27,31) FMOWOPWZWWLPCP-UHFFFAOYSA-N 517279 US11104690, Example 104::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(3- oxocyclobutyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 180 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517279 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517279&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522506 461603320 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090494 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1(CC1)C#N InChI=1S/C24H16ClFN4O/c25-20-4-2-1-3-18(20)22-19-10-5-15(23(31)28-24(14-27)11-12-24)13-21(19)30(29-22)17-8-6-16(26)7-9-17/h1-10,13H,11-12H2,(H,28,31) YDTWYYDEMILEQX-UHFFFAOYSA-N 517280 US11104690, Example 105::3-(2-chlorophenyl)-N-(1- cyanocyclopropyl)-1-(4- fluorophenyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 139 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517280 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517280&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522594 461603321 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090495 C[C@@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)[C@@H](O)c1ccccc1 |r| InChI=1S/C29H23ClFN3O2/c1-18(28(35)19-7-3-2-4-8-19)32-29(36)20-11-16-24-26(17-20)34(22-14-12-21(31)13-15-22)33-27(24)23-9-5-6-10-25(23)30/h2-18,28,35H,1H3,(H,32,36) YWQMVOJRMLTSCY-UHFFFAOYSA-N 517281 US11104690, Example 106::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1R,2S)-2- hydroxy-1-methyl-2- phenylethyl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 832 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517281 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517281&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522884 461603322 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090496 C[C@@H](NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)[C@H](O)c1ccccc1 |r| InChI=1S/C29H23ClFN3O2/c1-18(28(35)19-7-3-2-4-8-19)32-29(36)20-11-16-24-26(17-20)34(22-14-12-21(31)13-15-22)33-27(24)23-9-5-6-10-25(23)30/h2-18,28,35H,1H3,(H,32,36) YWQMVOJRMLTSCY-UHFFFAOYSA-N 517282 US11104690, Example 107::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1R,2R)-2- hydroxy-1-methyl-2- phenylethyl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 305 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517282 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517282&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522056 461603323 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090497 OC1CC(C1)(NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1ccc(Br)cc1 |(-3.05,-4.01,;-2.97,-2.47,;-4,-1.33,;-2.86,-.29,;-1.83,-1.44,;-1.49,.41,;-.2,-.43,;-.28,-1.97,;1.17,.27,;1.25,1.8,;2.63,2.5,;3.92,1.66,;5.4,2.06,;6.24,.77,;5.27,-.43,;5.67,-1.91,;4.58,-3,;4.98,-4.49,;6.47,-4.89,;6.87,-6.38,;7.56,-3.8,;7.16,-2.31,;3.84,.13,;2.46,-.57,;5.96,3.5,;7.48,3.74,;8.03,5.18,;7.06,6.38,;5.54,6.13,;4.99,4.7,;3.47,4.46,;-4.15,.55,;-4.07,2.08,;-5.37,2.92,;-6.74,2.22,;-8.03,3.06,;-6.82,.68,;-5.53,-.15,)| InChI=1S/C30H22BrClFN3O2/c31-20-8-6-19(7-9-20)30(16-23(37)17-30)34-29(38)18-5-14-25-27(15-18)36(22-12-10-21(33)11-13-22)35-28(25)24-3-1-2-4-26(24)32/h1-15,23,37H,16-17H2,(H,34,38) QBJQDISOOJOFLZ-UHFFFAOYSA-N 517283 US11104690, Example 108::N-[1-(4-bromophenyl)-3- hydroxycyclobutyl]-3-(2- chlorophenyl)-1-(4- fluorophenyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 393 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517283 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517283&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522917 461603324 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090498 Fc1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC(CCN1CCOCC1)c1ccccc1 InChI=1S/C33H30ClFN4O2/c34-29-9-5-4-8-27(29)32-28-15-10-24(22-31(28)39(37-32)26-13-11-25(35)12-14-26)33(40)36-30(23-6-2-1-3-7-23)16-17-38-18-20-41-21-19-38/h1-15,22,30H,16-21H2,(H,36,40) FTEWBMRAKORYPE-UHFFFAOYSA-N 517284 US11104690, Example 109::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(3-morpholin-4- yl-1-phenylpropyl)-1H-indazole- 6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 532 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517284 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517284&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522518 461603325 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090499 OC[C@H](Cc1ccccc1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C29H23ClFN3O2/c30-26-9-5-4-8-24(26)28-25-15-10-20(17-27(25)34(33-28)23-13-11-21(31)12-14-23)29(36)32-22(18-35)16-19-6-2-1-3-7-19/h1-15,17,22,35H,16,18H2,(H,32,36) DXKQZPINIXDTMS-UHFFFAOYSA-N 517286 US11104690, Example 110::N-[(1S)-1-benzyl-2- hydroxyethyl]-3-(2- chlorophenyl)-1-(4- fluorophenyl)-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 134 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517286 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517286&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134523863 461603327 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090500 CO[C@@H]1C[C@H](NC(=O)c2ccc3c(nn(-c4ccc(F)cc4)c3c2)-c2ccccc2Cl)[C@H](O)[C@H](C)O1 |r| InChI=1S/C27H25ClFN3O4/c1-15-26(33)22(14-24(35-2)36-15)30-27(34)16-7-12-20-23(13-16)32(18-10-8-17(29)9-11-18)31-25(20)19-5-3-4-6-21(19)28/h3-13,15,22,24,26,33H,14H2,1-2H3,(H,30,34) QDIXESDTKRRDBX-UHFFFAOYSA-N 517289 US11104690, Example 111::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-((2S,3S,4S,6S)- 3-hydroxy-6-methoxy-2- methyltetrahydro-2H-pyran-4-yl)- 1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 194 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517289 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517289&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522054 461603329 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090501 CC(Cc1ccccn1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C28H22ClFN4O/c1-18(16-21-6-4-5-15-31-21)32-28(35)19-9-14-24-26(17-19)34(22-12-10-20(30)11-13-22)33-27(24)23-7-2-3-8-25(23)29/h2-15,17-18H,16H2,1H3,(H,32,35) DJSPZVKTYANFJJ-UHFFFAOYSA-N 517290 US11104690, Example 112::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(1-methyl-2- pyridin-2-ylethyl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 593 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517290 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517290&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522376 461603330 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090502 CC(O)CC(C)(C)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl InChI=1S/C26H25ClFN3O2/c1-16(32)15-26(2,3)29-25(33)17-8-13-21-23(14-17)31(19-11-9-18(28)10-12-19)30-24(21)20-6-4-5-7-22(20)27/h4-14,16,32H,15H2,1-3H3,(H,29,33) NIVSDSCTVZNNAE-UHFFFAOYSA-N 517291 US11104690, Example 113::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(3-hydroxy-1,1- dimethylbutyl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 41.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517291 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517291&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522617 461603331 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090503 OC1(CNC(=O)c2ccc3c(nn(-c4ccc(F)cc4)c3c2)-c2ccccc2Cl)CC1 InChI=1S/C24H19ClFN3O2/c25-20-4-2-1-3-18(20)22-19-10-5-15(23(30)27-14-24(31)11-12-24)13-21(19)29(28-22)17-8-6-16(26)7-9-17/h1-10,13,31H,11-12,14H2,(H,27,30) CGRBGLIYVQSQLP-UHFFFAOYSA-N 517292 US11104690, Example 114::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1- hydroxycyclopropyl)methyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 627 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517292 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517292&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134523136 461603332 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090504 O[C@H]1CCC[C@H]1NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| InChI=1S/C25H21ClFN3O2/c26-20-5-2-1-4-18(20)24-19-13-8-15(25(32)28-21-6-3-7-23(21)31)14-22(19)30(29-24)17-11-9-16(27)10-12-17/h1-2,4-5,8-14,21,23,31H,3,6-7H2,(H,28,32) DQZNKQWAVMGUIN-UHFFFAOYSA-N 517293 US11104690, Example 115::3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-[(1R,2S)-2- hydroxycyclopentyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 578 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517293 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517293&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522562 461603333 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090505 Fc1ccc(cc1)-n1nc(-c2cccc(c2)C#N)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 InChI=1S/C25H19FN4O3S/c26-19-5-7-21(8-6-19)30-23-13-18(25(31)28-20-10-11-34(32,33)15-20)4-9-22(23)24(29-30)17-3-1-2-16(12-17)14-27/h1-9,12-13,20H,10-11,15H2,(H,28,31) OORHHHPGRNGJJR-UHFFFAOYSA-N 517294 US11104690, Example 116::3-(3-cyanophenyl)-N-(1,1- dioxidotetrahydrothiophen-3-yl)- 1-(4-fluorophenyl)-1H-indazole- 6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 359 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517294 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517294&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522149 461603334 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090506 CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cccc(c1)C#N InChI=1S/C26H21FN4O3S/c1-26(11-12-35(33,34)16-26)29-25(32)19-5-10-22-23(14-19)31(21-8-6-20(27)7-9-21)30-24(22)18-4-2-3-17(13-18)15-28/h2-10,13-14H,11-12,16H2,1H3,(H,29,32) MQQVYVFZGBOWEK-UHFFFAOYSA-N 517295 US11104690, Example 117::3-(3-cyanophenyl)-1-(4- fluorophenyl)-N-(3-methyl-1,1- dioxidotetrahydrothiophen-3-yl)- 1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 7.00 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517295 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517295&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522073 461603335 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090507 OCC1(CCC1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cc(ccc1Cl)C#N InChI=1S/C26H20ClFN4O2/c27-22-9-2-16(14-29)12-21(22)24-20-8-3-17(25(34)30-26(15-33)10-1-11-26)13-23(20)32(31-24)19-6-4-18(28)5-7-19/h2-9,12-13,33H,1,10-11,15H2,(H,30,34) OZMDDFOOQFKYES-UHFFFAOYSA-N 517296 US11104690, Example 118::3-(2-chloro-5-cyanophenyl)-1-(4- fluorophenyl)-N-[1- (hydroxymethyl)cyclobutyl]-1H- indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 5.50 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517296 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517296&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522128 461603336 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090508 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cc(ccc1Cl)C#N |r| InChI=1S/C26H20ClFN4O3S/c1-26(10-11-36(34,35)15-26)30-25(33)17-3-8-20-23(13-17)32(19-6-4-18(28)5-7-19)31-24(20)21-12-16(14-29)2-9-22(21)27/h2-9,12-13H,10-11,15H2,1H3,(H,30,33) VRQWZDXJKHQCRE-UHFFFAOYSA-N 517297 US11104690, Example 119-A::3-(2-chloro-5-cyanophenyl)-1-(4- fluorophenyl)-N-(3-methyl-1,1- dioxidotetrahydrothiophen-3-yl)- 1H-indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 8.40 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517297 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517297&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678337 461603337 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090509 Fc1ccc(cc1)-n1nc(-c2cc(ccc2Cl)C#N)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C25H18ClFN4O3S/c26-22-8-1-15(13-28)11-21(22)24-20-7-2-16(25(32)29-18-9-10-35(33,34)14-18)12-23(20)31(30-24)19-5-3-17(27)4-6-19/h1-8,11-12,18H,9-10,14H2,(H,29,32) LGDSQFWKAXFSFX-UHFFFAOYSA-N 517298 US11104690, Example 120-A::3-(2-chloro-5-cyanophenyl)-N- (1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluorophenyl)-1H- indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 4.20 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517298 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517298&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678338 461603338 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090510 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cc(ccc1Cl)C(N)=O |r| InChI=1S/C26H22ClFN4O4S/c1-26(10-11-37(35,36)14-26)30-25(34)16-2-8-19-22(13-16)32(18-6-4-17(28)5-7-18)31-23(19)20-12-15(24(29)33)3-9-21(20)27/h2-9,12-13H,10-11,14H2,1H3,(H2,29,33)(H,30,34) JNOASVWFSYSXAD-UHFFFAOYSA-N 517299 US11104690, Example 121-A::3-(5-carbamoyl-2-chlorophenyl)- 1-(4-fluorophenyl)-N-(3-methyl- 1,1-dioxidotetrahydrothiophen-3- yl)-1H-indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 132 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517299 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517299&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678339 461603339 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090511 C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cc(ccc1Cl)C#N |r| InChI=1S/C26H20ClFN4O3S/c1-26(10-11-36(34,35)15-26)30-25(33)17-3-8-20-23(13-17)32(19-6-4-18(28)5-7-19)31-24(20)21-12-16(14-29)2-9-22(21)27/h2-9,12-13H,10-11,15H2,1H3,(H,30,33) VRQWZDXJKHQCRE-UHFFFAOYSA-N 517300 US11104690, Example 119-B::3-(2-chloro-5-cyanophenyl)-1-(4- fluorophenyl)-N-(3-methyl-1,1- dioxidotetrahydrothiophen-3-yl)- 1H-indazole-6-carboxamide (enantiomer B) Diacylglycerol O-acyltransferase 2 Homo sapiens 2.50 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517300 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517300&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678340 461603340 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090512 C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cc(ccc1Cl)C(N)=O |r| InChI=1S/C26H22ClFN4O4S/c1-26(10-11-37(35,36)14-26)30-25(34)16-2-8-19-22(13-16)32(18-6-4-17(28)5-7-18)31-23(19)20-12-15(24(29)33)3-9-21(20)27/h2-9,12-13H,10-11,14H2,1H3,(H2,29,33)(H,30,34) JNOASVWFSYSXAD-UHFFFAOYSA-N 517301 US11104690, Example 121-B::3-(5-carbamoyl-2-chlorophenyl)- 1-(4-fluorophenyl)-N-(3-methyl- 1,1-dioxidotetrahydrothiophen-3- yl)-1H-indazole-6-carboxamide (enantiomer B) Diacylglycerol O-acyltransferase 2 Homo sapiens 61.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517301 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517301&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678341 461603341 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090513 NC(=O)c1ccc(Cl)c(c1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C25H20ClFN4O4S/c26-21-8-2-14(24(28)32)11-20(21)23-19-7-1-15(25(33)29-17-9-10-36(34,35)13-17)12-22(19)31(30-23)18-5-3-16(27)4-6-18/h1-8,11-12,17H,9-10,13H2,(H2,28,32)(H,29,33) SUBFAADUQYFJHG-UHFFFAOYSA-N 517302 US11104690, Example 122-A::3-(5-carbamoyl-2-chlorophenyl)- N-(1,1- dioxidotetrahydrothiophen-3-yl)- 1-(4-fluorophenyl)-1H-indazole- 6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 96.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517302 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517302&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678342 461603342 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090514 CC(C)[C@@H](CO)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cc(ccc1Cl)C#N |r| InChI=1S/C26H22ClFN4O2/c1-15(2)23(14-33)30-26(34)17-4-9-20-24(12-17)32(19-7-5-18(28)6-8-19)31-25(20)21-11-16(13-29)3-10-22(21)27/h3-12,15,23,33H,14H2,1-2H3,(H,30,34) CVJHDHLEPSCDGR-UHFFFAOYSA-N 517303 US11104690, Example 123::3-(2-chloro-5-cyanophenyl)-1-(4- fluorophenyl)-N-[(1S)-1- (hydroxymethyl)-2- methylpropyl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 3.80 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517303 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517303&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522485 461603343 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090515 C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cccc(c1)C#N |r| InChI=1S/C26H21FN4O3S/c1-26(11-12-35(33,34)16-26)29-25(32)19-5-10-22-23(14-19)31(21-8-6-20(27)7-9-21)30-24(22)18-4-2-3-17(13-18)15-28/h2-10,13-14H,11-12,16H2,1H3,(H,29,32) MQQVYVFZGBOWEK-UHFFFAOYSA-N 517304 US11104690, Example 117-B::3-(3-cyanophenyl)-1-(4- fluorophenyl)-N-(3-methyl-1,1- dioxidotetrahydrothiophen-3-yl)- 1H-indazole-6-carboxamide (enantiomer B) Diacylglycerol O-acyltransferase 2 Homo sapiens 6.40 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517304 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517304&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678343 461603344 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090516 CC(C)[C@@H](CO)NC(=O)c1ccc2c(nn(-c3ccc(F)cn3)c2c1)-c1cccc(c1)C1CC1 |r| InChI=1S/C27H27FN4O2/c1-16(2)23(15-33)30-27(34)20-8-10-22-24(13-20)32(25-11-9-21(28)14-29-25)31-26(22)19-5-3-4-18(12-19)17-6-7-17/h3-5,8-14,16-17,23,33H,6-7,15H2,1-2H3,(H,30,34) MUJNGTVHCAGXGH-UHFFFAOYSA-N 517305 US11104690, Example 124::3-(3-cyclopropylphenyl)-1-(5- fluoropyridin-2-yl)-N-[(1S)-1- (hydroxymethyl)-2- methylpropyl]-1H-indazole-6- carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 4.40 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517305 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517305&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522502 461603345 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090517 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cn3)c2c1)-c1cccc(c1)C1CC1 |r| InChI=1S/C27H25FN4O3S/c1-27(11-12-36(34,35)16-27)30-26(33)20-7-9-22-23(14-20)32(24-10-8-21(28)15-29-24)31-25(22)19-4-2-3-18(13-19)17-5-6-17/h2-4,7-10,13-15,17H,5-6,11-12,16H2,1H3,(H,30,33) RGVCYCKUDOKILX-UHFFFAOYSA-N 517306 US11104690, Example 125-A::3-(3-cyclopropylphenyl)-1-(5- fluoropyridin-2-yl)-N-(3-methyl- 1,1-dioxidotetrahydrothiophen-3- yl)-1H-indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 4.20 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517306 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517306&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678344 461603346 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090518 C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cn3)c2c1)-c1cccc(c1)C1CC1 |r| InChI=1S/C27H25FN4O3S/c1-27(11-12-36(34,35)16-27)30-26(33)20-7-9-22-23(14-20)32(24-10-8-21(28)15-29-24)31-25(22)19-4-2-3-18(13-19)17-5-6-17/h2-4,7-10,13-15,17H,5-6,11-12,16H2,1H3,(H,30,33) RGVCYCKUDOKILX-UHFFFAOYSA-N 517307 US11104690, Example 125-B::3-(3-cyclopropylphenyl)-1-(5- fluoropyridin-2-yl)-N-(3-methyl- 1,1-dioxidotetrahydrothiophen-3- yl)-1H-indazole-6-carboxamide (enantiomer B) Diacylglycerol O-acyltransferase 2 Homo sapiens 3.00 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517307 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517307&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678345 461603347 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090519 Fc1ccc(nc1)-n1nc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C26H23FN4O3S/c27-20-7-9-24(28-14-20)31-23-13-19(26(32)29-21-10-11-35(33,34)15-21)6-8-22(23)25(30-31)18-3-1-2-17(12-18)16-4-5-16/h1-3,6-9,12-14,16,21H,4-5,10-11,15H2,(H,29,32) FQDZGPGPCKCRSY-UHFFFAOYSA-N 517308 US11104690, Example 126-A::3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrothiophen-3-yl)- 1-(5-fluoropyridin-2-yl)-1H- indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 11.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517308 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517308&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678346 461603348 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090520 Fc1ccc(nc1)-n1nc(-c2cc(ccc2Cl)C#N)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C24H17ClFN5O3S/c25-20-5-1-14(11-27)9-19(20)23-18-4-2-15(24(32)29-17-7-8-35(33,34)13-17)10-21(18)31(30-23)22-6-3-16(26)12-28-22/h1-6,9-10,12,17H,7-8,13H2,(H,29,32) KQFPHJVIRRERAD-UHFFFAOYSA-N 517309 US11104690, Example 127-A::3-(2-chloro-5-cyanophenyl)-N- (1,1-dioxidotetrahydrothiophen- 3-yl)-1-(5-fluoropyridin-2-yl)- 1H-indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 8.20 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517309 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517309&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678347 461603349 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090521 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cn3)c2c1)-c1cccc(OC(F)F)c1 |r| InChI=1S/C25H21F3N4O4S/c1-25(9-10-37(34,35)14-25)30-23(33)16-5-7-19-20(12-16)32(21-8-6-17(26)13-29-21)31-22(19)15-3-2-4-18(11-15)36-24(27)28/h2-8,11-13,24H,9-10,14H2,1H3,(H,30,33) NKGNVRFBFMKXKW-UHFFFAOYSA-N 517310 US11104690, Example 128-A::3-[3-(difluoromethoxy)phenyl]-1- (5-fluoropyridin-2-yl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen-3-yl)- 1H-indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 3.30 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517310 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517310&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678348 461603350 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090522 Fc1ccc(cc1)-n1nc(-c2cccc(c2)C#N)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C25H19FN4O3S/c26-19-5-7-21(8-6-19)30-23-13-18(25(31)28-20-10-11-34(32,33)15-20)4-9-22(23)24(29-30)17-3-1-2-16(12-17)14-27/h1-9,12-13,20H,10-11,15H2,(H,28,31) OORHHHPGRNGJJR-UHFFFAOYSA-N 517311 US11104690, Example 129-A Diacylglycerol O-acyltransferase 2 Homo sapiens 10.00 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517311 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517311&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678349 461603351 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090523 Fc1ccc(cc1)-n1nc(-c2cccc(Cl)c2Cl)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C24H18Cl2FN3O3S/c25-20-3-1-2-19(22(20)26)23-18-9-4-14(24(31)28-16-10-11-34(32,33)13-16)12-21(18)30(29-23)17-7-5-15(27)6-8-17/h1-9,12,16H,10-11,13H2,(H,28,31) NYJVYDLBYKTWJM-UHFFFAOYSA-N 517312 US11104690, Example 130-A::3-(2,3-dichlorophenyl)-N- (1,1-dioxidotetrahydro- thiophen-3-yl)-1-(4- fluorophenyl)-1H-indazole- 6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 3.60 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517312 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517312&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678350 461603352 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090524 COc1cccc(c1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C25H22FN3O4S/c1-33-21-4-2-3-16(13-21)24-22-10-5-17(25(30)27-19-11-12-34(31,32)15-19)14-23(22)29(28-24)20-8-6-18(26)7-9-20/h2-10,13-14,19H,11-12,15H2,1H3,(H,27,30) XCEXOVYIRCRDFV-UHFFFAOYSA-N 517314 US11104690, Example 131-A::N-(1,1- dioxidotetrahydrothiophen- 3-yl)-1-(4-fluorophenyl)-3- (3-methoxyphenyl)-1H- indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 3.00 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517314 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517314&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678351 461603354 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090525 Fc1ccc(cc1)-n1nc(-c2c(F)cccc2F)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r,wD:27.30,(6.03,-6.45,;5.63,-4.96,;4.14,-4.57,;3.74,-3.08,;4.83,-1.99,;6.32,-2.39,;6.72,-3.88,;4.43,-.5,;5.34,.74,;4.43,1.99,;4.83,3.48,;6.32,3.88,;7.41,2.79,;6.72,5.36,;5.63,6.45,;4.14,6.05,;3.74,4.57,;2.25,4.17,;2.97,1.51,;1.63,2.28,;.3,1.51,;.3,-.03,;1.63,-.8,;2.97,-.03,;-1.03,-.8,;-1.03,-2.34,;-2.37,-.03,;-3.7,-.8,;-3.7,-2.34,;-5.17,-2.81,;-6.07,-1.57,;-7.41,-.8,;-7.41,-2.34,;-5.17,-.32,)| InChI=1S/C24H18F3N3O3S/c25-15-5-7-17(8-6-15)30-21-12-14(24(31)28-16-10-11-34(32,33)13-16)4-9-18(21)23(29-30)22-19(26)2-1-3-20(22)27/h1-9,12,16H,10-11,13H2,(H,28,31) HMUQPLCRCHUSAD-UHFFFAOYSA-N 517315 US11104690, Example 132-A::3-(2,6-difluorophenyl)-N- (1,1-dioxidotetrahydro- thiophen-3-yl)-1-(4- fluorophenyl)-1H-indazole- 6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 25.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517315 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517315&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678352 461603355 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090526 Fc1ccc(cc1)-n1nc(-c2cncnc2)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C22H18FN5O3S/c23-16-2-4-18(5-3-16)28-20-9-14(22(29)26-17-7-8-32(30,31)12-17)1-6-19(20)21(27-28)15-10-24-13-25-11-15/h1-6,9-11,13,17H,7-8,12H2,(H,26,29) WOPFLMJZYFCQEH-UHFFFAOYSA-N 517316 US11104690, Example 133-A::N-(1,1- dioxidotetrahydrothiophen- 3-yl)-1-(4-fluorophenyl)-3- pyrimidin-5-yl-1H-indazole- 6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 846 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517316 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517316&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678353 461603356 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090527 Fc1ccc(cc1)-n1nc(-c2cccnc2)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C23H19FN4O3S/c24-17-4-6-19(7-5-17)28-21-12-15(23(29)26-18-9-11-32(30,31)14-18)3-8-20(21)22(27-28)16-2-1-10-25-13-16/h1-8,10,12-13,18H,9,11,14H2,(H,26,29) GNADROMXSJGMLO-UHFFFAOYSA-N 517317 US11104690, Example 134-A::N-(1,1- dioxidotetrahydrothiophen- 3-yl)-1-(4-fluorophenyl)-3- pyridin-3-yl-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 212 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517317 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517317&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678354 461603357 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090528 Fc1ccc(cc1)-n1nc(-c2cccnc2Cl)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C23H18ClFN4O3S/c24-22-19(2-1-10-26-22)21-18-8-3-14(23(30)27-16-9-11-33(31,32)13-16)12-20(18)29(28-21)17-6-4-15(25)5-7-17/h1-8,10,12,16H,9,11,13H2,(H,27,30) YVQAPEIMUIMCMF-UHFFFAOYSA-N 517318 US11104690, Example 135-A::3-(2-chloropyridin-3-yl)-N- (1,1- dioxidotetrahydrothiophen- 3-yl)-1-(4-fluorophenyl)- 1H-indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 65.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517318 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517318&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678355 461603358 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090529 FC(F)Oc1cccc(c1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C25H20F3N3O4S/c26-17-5-7-19(8-6-17)31-22-13-16(24(32)29-18-10-11-36(33,34)14-18)4-9-21(22)23(30-31)15-2-1-3-20(12-15)35-25(27)28/h1-9,12-13,18,25H,10-11,14H2,(H,29,32) KBZAOZKBBKIYEP-UHFFFAOYSA-N 517319 US11104690, Example 136-A::3-[3- (difluoromethoxy)phenyl]- N-(1,1- dioxidotetrahydrothiophen- 3-yl)-1-(4-fluorophenyl)- 1H-indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 1.40 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517319 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517319&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678356 461603359 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090530 OCc1cc(-c2nn(-c3ccc(F)cc3)c3cc(ccc23)C(=O)N[C@@H]2CCS(=O)(=O)C2)c(Cl)cn1 |r| InChI=1S/C24H20ClFN4O4S/c25-21-11-27-17(12-31)10-20(21)23-19-6-1-14(24(32)28-16-7-8-35(33,34)13-16)9-22(19)30(29-23)18-4-2-15(26)3-5-18/h1-6,9-11,16,31H,7-8,12-13H2,(H,28,32) PUIBIEUMPBJXMH-UHFFFAOYSA-N 517320 US11104690, Example 137-A::3-(5-chloro-2- methoxypyridin-4-yl)-N- (1,1- dioxidotetrahydrothiophen- 3-yl)-1-(4-fluorophenyl)- 1H-indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 5.40 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517320 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517320&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678357 461603360 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090531 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccc2OCOc2c1 |r| InChI=1S/C26H22FN3O5S/c1-26(10-11-36(32,33)14-26)28-25(31)17-2-8-20-21(12-17)30(19-6-4-18(27)5-7-19)29-24(20)16-3-9-22-23(13-16)35-15-34-22/h2-9,12-13H,10-11,14-15H2,1H3,(H,28,31) WFCMNLDLCNZTLX-UHFFFAOYSA-N 517321 US11104690, Example 139-A::3-(1,3-benzodioxol-5-yl)-1- (4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 229 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517321 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517321&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678358 461603361 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090532 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccc2OCOc2c1 |r| InChI=1S/C26H22FN3O5S/c1-26(10-11-36(32,33)14-26)28-25(31)17-2-8-20-21(12-17)30(19-6-4-18(27)5-7-19)29-24(20)16-3-9-22-23(13-16)35-15-34-22/h2-9,12-13H,10-11,14-15H2,1H3,(H,28,31) WFCMNLDLCNZTLX-UHFFFAOYSA-N 517321 US11104690, Example 139-A::3-(1,3-benzodioxol-5-yl)-1- (4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 158 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517321 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517321&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678358 461603361 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090533 COc1cc(ccn1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@]1(C)CCS(=O)(=O)C1 |r| InChI=1S/C25H23FN4O4S/c1-25(10-12-35(32,33)15-25)28-24(31)17-3-8-20-21(13-17)30(19-6-4-18(26)5-7-19)29-23(20)16-9-11-27-22(14-16)34-2/h3-9,11,13-14H,10,12,15H2,1-2H3,(H,28,31) JOTKOPODZHXULC-UHFFFAOYSA-N 517322 US11104690, Example 140-A::1-(4-fluorophenyl)-3-(2- methoxypyridin-4-yl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 455 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517322 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517322&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678359 461603362 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090534 COc1cc(-c2nn(-c3ccc(F)cc3)c3cc(ccc23)C(=O)N[C@]2(C)CCS(=O)(=O)C2)c(Cl)cn1 |r| InChI=1S/C25H22ClFN4O4S/c1-25(9-10-36(33,34)14-25)29-24(32)15-3-8-18-21(11-15)31(17-6-4-16(27)5-7-17)30-23(18)19-12-22(35-2)28-13-20(19)26/h3-8,11-13H,9-10,14H2,1-2H3,(H,29,32) UJXXPTLGRLDFRV-UHFFFAOYSA-N 517323 US11104690, Example 141-A::3-(5-chloro-2- methoxypyridin-4-yl)-1-(4- fluorophenyl)-N-(3-methyl- 1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 4.80 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517323 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517323&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678360 461603363 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090535 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cc(Cl)cnc1CO |r| InChI=1S/C25H22ClFN4O4S/c1-25(8-9-36(34,35)14-25)29-24(33)15-2-7-19-22(10-15)31(18-5-3-17(27)4-6-18)30-23(19)20-11-16(26)12-28-21(20)13-32/h2-7,10-12,32H,8-9,13-14H2,1H3,(H,29,33) ZNVXEJSGRXGCCQ-UHFFFAOYSA-N 517324 US11104690, Example 142-A::3-(5-chloro-2- methoxypyridin-3-yl)-1-(4- fluorophenyl)-N-(3-methyl- 1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 430 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517324 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517324&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678361 461603364 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090536 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cccc(OC(F)F)c1 |r| InChI=1S/C26H22F3N3O4S/c1-26(11-12-37(34,35)15-26)30-24(33)17-5-10-21-22(14-17)32(19-8-6-18(27)7-9-19)31-23(21)16-3-2-4-20(13-16)36-25(28)29/h2-10,13-14,25H,11-12,15H2,1H3,(H,30,33) XVPLGPINRPQMLZ-UHFFFAOYSA-N 517325 US11104690, Example 143-A::3-[3- (difluoromethoxy)phenyl]- 1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 1.60 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517325 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517325&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678362 461603365 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090537 COc1cccc(c1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@]1(C)CCS(=O)(=O)C1 |r| InChI=1S/C26H24FN3O4S/c1-26(12-13-35(32,33)16-26)28-25(31)18-6-11-22-23(15-18)30(20-9-7-19(27)8-10-20)29-24(22)17-4-3-5-21(14-17)34-2/h3-11,14-15H,12-13,16H2,1-2H3,(H,28,31) RNDYKEZVDBZRTQ-UHFFFAOYSA-N 517326 US11104690, Example 144-A::1-(4-fluorophenyl)-3-(3- methoxyphenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 5.80 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517326 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517326&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678363 461603366 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090538 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cccc(c1)C1CC1 |r| InChI=1S/C28H26FN3O3S/c1-28(13-14-36(34,35)17-28)30-27(33)21-7-12-24-25(16-21)32(23-10-8-22(29)9-11-23)31-26(24)20-4-2-3-19(15-20)18-5-6-18/h2-4,7-12,15-16,18H,5-6,13-14,17H2,1H3,(H,30,33) YTLBGGKJVRYAEF-UHFFFAOYSA-N 517327 US11104690, Example 145-A::3-(3-cyclopropylphenyl)-1- (4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 2.10 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517327 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517327&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678364 461603367 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090539 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cncc(c1)C#N |r| InChI=1S/C25H20FN5O3S/c1-25(8-9-35(33,34)15-25)29-24(32)17-2-7-21-22(11-17)31(20-5-3-19(26)4-6-20)30-23(21)18-10-16(12-27)13-28-14-18/h2-7,10-11,13-14H,8-9,15H2,1H3,(H,29,32) NSLNROXFFAXKGJ-UHFFFAOYSA-N 517328 US11104690, Example 146-A::3-(5-cyanopyridin-3-yl)-1- (4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 63.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517328 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517328&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678365 461603368 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090540 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cccc(OCC(F)(F)F)c1 |r| InChI=1S/C27H23F4N3O4S/c1-26(11-12-39(36,37)16-26)32-25(35)18-5-10-22-23(14-18)34(20-8-6-19(28)7-9-20)33-24(22)17-3-2-4-21(13-17)38-15-27(29,30)31/h2-10,13-14H,11-12,15-16H2,1H3,(H,32,35) LQSNPFYFXAWOOH-UHFFFAOYSA-N 517329 US11104690, Example 147-A::1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-3-[3-(2,2,2- trifluoroethoxy)phenyl]-1H- indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 5.70 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517329 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517329&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678366 461603369 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090541 CN(C)C(=O)c1cccc(c1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@]1(C)CCS(=O)(=O)C1 |r| InChI=1S/C28H27FN4O4S/c1-28(13-14-38(36,37)17-28)30-26(34)19-7-12-23-24(16-19)33(22-10-8-21(29)9-11-22)31-25(23)18-5-4-6-20(15-18)27(35)32(2)3/h4-12,15-16H,13-14,17H2,1-3H3,(H,30,34) BYSWNGPXYDJNQJ-UHFFFAOYSA-N 517330 US11104690, Example 148- Diacylglycerol O-acyltransferase 2 Homo sapiens 855 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517330 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517330&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678367 461603370 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090542 CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cccc(c1)C(N)=O InChI=1S/C26H23FN4O4S/c1-26(11-12-36(34,35)15-26)29-25(33)18-5-10-21-22(14-18)31(20-8-6-19(27)7-9-20)30-23(21)16-3-2-4-17(13-16)24(28)32/h2-10,13-14H,11-12,15H2,1H3,(H2,28,32)(H,29,33) MNUZTLWQMNMOTD-UHFFFAOYSA-N 517331 US11104690, Example 149::3-(3-carbamoylphenyl)-1- (4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 249 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517331 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517331&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522635 461603371 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090543 CC(C)(O)c1cccc(c1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)C1 InChI=1S/C28H28FN3O4S/c1-27(2,34)20-6-4-5-18(15-20)25-23-12-7-19(26(33)30-28(3)13-14-37(35,36)17-28)16-24(23)32(31-25)22-10-8-21(29)9-11-22/h4-12,15-16,34H,13-14,17H2,1-3H3,(H,30,33) ICXHLRRSBSKLON-UHFFFAOYSA-N 517332 US11104690, Example 150::1-(4-fluorophenyl)-3-[3-(1- hydroxy-1- methylethyl)phenyl]-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 311 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517332 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517332&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522958 461603372 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090544 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cc(ccc1F)C#N |r| InChI=1S/C26H20F2N4O3S/c1-26(10-11-36(34,35)15-26)30-25(33)17-3-8-20-23(13-17)32(19-6-4-18(27)5-7-19)31-24(20)21-12-16(14-29)2-9-22(21)28/h2-9,12-13H,10-11,15H2,1H3,(H,30,33) VYZNRYRWALHIOT-UHFFFAOYSA-N 517333 US11104690, Example 151-A::3-(5-cyano-2-fluorophenyl)- 1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 4.50 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517333 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517333&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678368 461603373 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090545 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccc(Cl)nc1F |r| InChI=1S/C24H19ClF2N4O3S/c1-24(10-11-35(33,34)13-24)29-23(32)14-2-7-17-19(12-14)31(16-5-3-15(26)4-6-16)30-21(17)18-8-9-20(25)28-22(18)27/h2-9,12H,10-11,13H2,1H3,(H,29,32) RWPNFNCBSQWDNU-UHFFFAOYSA-N 517334 US11104690, Example 152-A::3-(6-chloro-2-fluoropyridin- 3-yl)-1-(4-fluorophenyl)-N- (3-methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 4.50 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517334 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517334&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678369 461603374 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090546 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cncc(F)c1 |r| InChI=1S/C24H20F2N4O3S/c1-24(8-9-34(32,33)14-24)28-23(31)15-2-7-20-21(11-15)30(19-5-3-17(25)4-6-19)29-22(20)16-10-18(26)13-27-12-16/h2-7,10-13H,8-9,14H2,1H3,(H,28,31) WUQKFPOLHOMUNC-UHFFFAOYSA-N 517335 US11104690, Example 153-A::1-(4-fluorophenyl)-3-(5- fluoropyridin-3-yl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 90.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517335 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517335&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678370 461603375 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090547 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cccnc1F |r| InChI=1S/C24H20F2N4O3S/c1-24(10-12-34(32,33)14-24)28-23(31)15-4-9-18-20(13-15)30(17-7-5-16(25)6-8-17)29-21(18)19-3-2-11-27-22(19)26/h2-9,11,13H,10,12,14H2,1H3,(H,28,31) OMOSZDKXYCJSQI-UHFFFAOYSA-N 517336 US11104690, Example 154-A::1-(4-fluorophenyl)-3-(2- fluoropyridin-3-yl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 17.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517336 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517336&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678371 461603376 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090548 COc1ccc(cn1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@]1(C)CCS(=O)(=O)C1 |r| InChI=1S/C25H23FN4O4S/c1-25(11-12-35(32,33)15-25)28-24(31)16-3-9-20-21(13-16)30(19-7-5-18(26)6-8-19)29-23(20)17-4-10-22(34-2)27-14-17/h3-10,13-14H,11-12,15H2,1-2H3,(H,28,31) BGUIVTRNEOHRKZ-UHFFFAOYSA-N 517337 US11104690, Example 155-A::1-(4-fluorophenyl)-3-(6- methoxypyridin-3-yl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 353 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517337 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517337&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678372 461603377 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090549 Cc1cccc(c1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@]1(C)CCS(=O)(=O)C1 |r| InChI=1S/C26H24FN3O3S/c1-17-4-3-5-18(14-17)24-22-11-6-19(25(31)28-26(2)12-13-34(32,33)16-26)15-23(22)30(29-24)21-9-7-20(27)8-10-21/h3-11,14-15H,12-13,16H2,1-2H3,(H,28,31) BOWJXWVGECXFGZ-UHFFFAOYSA-N 517338 US11104690, Example 156-A::1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-3-(3-methylphenyl)- 1H-indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 11.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517338 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517338&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678373 461603378 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090550 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cc(Cl)cc(Cl)c1 |r| InChI=1S/C25H20Cl2FN3O3S/c1-25(8-9-35(33,34)14-25)29-24(32)15-2-7-21-22(12-15)31(20-5-3-19(28)4-6-20)30-23(21)16-10-17(26)13-18(27)11-16/h2-7,10-13H,8-9,14H2,1H3,(H,29,32) MGHIANWRGCHCTD-UHFFFAOYSA-N 517339 US11104690, Example 157-A::3-(3,5-dichlorophenyl)-1-(4- fluorophenyl)-N-(3-methyl- 1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 61.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517339 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517339&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678374 461603379 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090551 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cccc(Cl)c1 |r| InChI=1S/C25H21ClFN3O3S/c1-25(11-12-34(32,33)15-25)28-24(31)17-5-10-21-22(14-17)30(20-8-6-19(27)7-9-20)29-23(21)16-3-2-4-18(26)13-16/h2-10,13-14H,11-12,15H2,1H3,(H,28,31) MFKATXCUDKVFFW-UHFFFAOYSA-N 517361 US11104690, Example 158-A::3-(3-chlorophenyl)-1-(4- fluorophenyl)-N-(3-methyl- 1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 31.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517361 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517361&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678375 461603401 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090552 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccnc(c1)C(F)(F)F |r| InChI=1S/C25H20F4N4O3S/c1-24(9-11-37(35,36)14-24)31-23(34)16-2-7-19-20(12-16)33(18-5-3-17(26)4-6-18)32-22(19)15-8-10-30-21(13-15)25(27,28)29/h2-8,10,12-13H,9,11,14H2,1H3,(H,31,34) AXFIGZXAWWFJIN-UHFFFAOYSA-N 517362 US11104690, Example 159-A::1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-3-[2- (trifluoromethyl)pyridin-4- yl]-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 469 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517362 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517362&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678376 461603402 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090553 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cc(ccc1Cl)C(F)(F)F |r| InChI=1S/C26H20ClF4N3O3S/c1-25(10-11-38(36,37)14-25)32-24(35)15-2-8-19-22(12-15)34(18-6-4-17(28)5-7-18)33-23(19)20-13-16(26(29,30)31)3-9-21(20)27/h2-9,12-13H,10-11,14H2,1H3,(H,32,35) XYFRVPURJJCOBW-UHFFFAOYSA-N 517363 US11104690, Example 160-A::3-[2-chloro-5- (trifluoromethyl)phenyl]-1- (4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 6.90 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517363 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517363&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678377 461603403 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090554 COc1cc(cc(-c2nn(-c3ccc(F)cc3)c3cc(ccc23)C(=O)N[C@@]2(C)CCS(=O)(=O)C2)c1F)C#N |r| InChI=1S/C27H22F2N4O4S/c1-27(9-10-38(35,36)15-27)31-26(34)17-3-8-20-22(13-17)33(19-6-4-18(28)5-7-19)32-25(20)21-11-16(14-30)12-23(37-2)24(21)29/h3-8,11-13H,9-10,15H2,1-2H3,(H,31,34) LWJXLRBZUSNBHS-UHFFFAOYSA-N 517364 US11104690, Example 161-B::3-(5-cyano-2-fluoro-3- methoxyphenyl)-1-(4- fluorophenyl)-N-(3-methyl- 1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer B) Diacylglycerol O-acyltransferase 2 Homo sapiens 28.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517364 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517364&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678378 461603404 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090555 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1ccccc1 |r| InChI=1S/C25H22FN3O3S/c1-25(13-14-33(31,32)16-25)27-24(30)18-7-12-21-22(15-18)29(20-10-8-19(26)9-11-20)28-23(21)17-5-3-2-4-6-17/h2-12,15H,13-14,16H2,1H3,(H,27,30) FDFBWOYTYNTNTH-UHFFFAOYSA-N 517365 US11104690, Example 162-A::1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-3-phenyl-1H-indazole- 6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 157 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517365 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517365&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678379 461603405 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090556 Cn1nnc2ccc(cc12)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)C1 InChI=1S/C26H23FN6O3S/c1-26(11-12-37(35,36)15-26)28-25(34)17-3-9-20-22(14-17)33(19-7-5-18(27)6-8-19)30-24(20)16-4-10-21-23(13-16)32(2)31-29-21/h3-10,13-14H,11-12,15H2,1-2H3,(H,28,34) FPZDGTCZXLHBJM-UHFFFAOYSA-N 517366 US11104690, Example 163::1-(4-fluorophenyl)-3-(1- methyl-1H-benzotriazol-6- yl)-N-(3-methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 340 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517366 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517366&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522508 461603406 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090557 Cc1nnc(o1)-c1cccc(c1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)C1 InChI=1S/C28H24FN5O4S/c1-17-31-32-27(38-17)20-5-3-4-18(14-20)25-23-11-6-19(26(35)30-28(2)12-13-39(36,37)16-28)15-24(23)34(33-25)22-9-7-21(29)8-10-22/h3-11,14-15H,12-13,16H2,1-2H3,(H,30,35) ALSYRVXWMKUHBU-UHFFFAOYSA-N 517367 US11104690, Example 164::1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-3-[3-(5-methyl-1,3,4- oxadiazol-2-yl)phenyl]-1H- indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 28.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517367 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517367&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522812 461603407 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090558 CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cccc(c1)-n1cccn1 InChI=1S/C28H24FN5O3S/c1-28(12-15-38(36,37)18-28)31-27(35)20-6-11-24-25(17-20)34(22-9-7-21(29)8-10-22)32-26(24)19-4-2-5-23(16-19)33-14-3-13-30-33/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,31,35) BCRRNAFRJZTCOS-UHFFFAOYSA-N 517368 US11104690, Example 165::1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-3-[3-(1H-pyrazol-1- yl)phenyl]-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 7.00 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517368 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517368&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522633 461603408 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090559 [O-][n+]1cccc(c1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 InChI=1S/C23H19FN4O4S/c24-17-4-6-19(7-5-17)28-21-12-15(23(29)25-18-9-11-33(31,32)14-18)3-8-20(21)22(26-28)16-2-1-10-27(30)13-16/h1-8,10,12-13,18H,9,11,14H2,(H,25,29) MPGRDAHTZGDVKH-UHFFFAOYSA-N 517369 US11104690, Example 166-A::3-(6-((1,1- dioxidotetrahydrothiophen- 3-yl)carbamoyl)-1-(4- fluorophenyl)-1H-indazol-3- yl)pyridine 1-oxide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 843 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517369 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517369&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522120 461603409 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090560 Clc1ccccc1-c1nn(Cc2ccccc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 |w:25.29| InChI=1S/C25H22ClN3O3S/c26-22-9-5-4-8-20(22)24-21-11-10-18(25(30)27-19-12-13-33(31,32)16-19)14-23(21)29(28-24)15-17-6-2-1-3-7-17/h1-11,14,19H,12-13,15-16H2,(H,27,30) LXUHCHYANLVXGI-UHFFFAOYSA-N 517370 US11104690, Example 167 Diacylglycerol O-acyltransferase 2 Homo sapiens 383 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517370 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517370&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522777 461603410 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090561 Clc1ccc(Cn2nc(-c3ccccc3Cl)c3ccc(cc23)C(=O)NC2CCS(=O)(=O)C2)cc1 InChI=1S/C25H21Cl2N3O3S/c26-18-8-5-16(6-9-18)14-30-23-13-17(25(31)28-19-11-12-34(32,33)15-19)7-10-21(23)24(29-30)20-3-1-2-4-22(20)27/h1-10,13,19H,11-12,14-15H2,(H,28,31) AQVKVSUVKRZSTB-UHFFFAOYSA-N 517371 US11104690, Example 168::1-(4-chlorobenzyl)-3-(2- chlorophenyl)-N-(1,1- dioxidotetrahydrothiophen-3-yl)- 1H-indazole-6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 455 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517371 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517371&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522569 461603411 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090562 CC(C)n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 InChI=1S/C21H22ClN3O3S/c1-13(2)25-19-11-14(21(26)23-15-9-10-29(27,28)12-15)7-8-17(19)20(24-25)16-5-3-4-6-18(16)22/h3-8,11,13,15H,9-10,12H2,1-2H3,(H,23,26) CTZYVSKZVVTIMZ-UHFFFAOYSA-N 517372 US11104690, Example 169::3-(2-chlorophenyl)-N-(1,1- dioxidotetrahydrothiophen-3-yl)- 1-(1-methylethyl)-1H-indazole- 6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 364 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517372 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517372&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134523059 461603412 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090563 Fc1ccc(Cn2nc(-c3ccccc3Cl)c3ccc(cc23)C(=O)NC2CCS(=O)(=O)C2)cc1 InChI=1S/C25H21ClFN3O3S/c26-22-4-2-1-3-20(22)24-21-10-7-17(25(31)28-19-11-12-34(32,33)15-19)13-23(21)30(29-24)14-16-5-8-18(27)9-6-16/h1-10,13,19H,11-12,14-15H2,(H,28,31) YLYVHYDVPZLUAQ-UHFFFAOYSA-N 517373 US11104690, Example 170::3-(2-chlorophenyl)-N-(1,1- dioxidotetrahydrothiophen-3-yl)- 1-(4-fluorobenzyl)-1H-indazole- 6-carboxamide Diacylglycerol O-acyltransferase 2 Homo sapiens 179 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517373 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517373&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 142354450 461603413 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090564 C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(Cl)cn3)c2c1)-c1ccccc1Cl |r| InChI=1S/C24H20Cl2N4O3S/c1-24(10-11-34(32,33)14-24)28-23(31)15-6-8-18-20(12-15)30(21-9-7-16(25)13-27-21)29-22(18)17-4-2-3-5-19(17)26/h2-9,12-13H,10-11,14H2,1H3,(H,28,31) PYDLLVYWUZZQGV-UHFFFAOYSA-N 517374 US11104690, Example 171-A Diacylglycerol O-acyltransferase 2 Homo sapiens 15.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517374 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517374&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678380 461603414 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090565 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cn3)c2c1)-c1ccccc1Cl |r| InChI=1S/C24H20ClFN4O3S/c1-24(10-11-34(32,33)14-24)28-23(31)15-6-8-18-20(12-15)30(21-9-7-16(26)13-27-21)29-22(18)17-4-2-3-5-19(17)25/h2-9,12-13H,10-11,14H2,1H3,(H,28,31) OASRJZUKIRTQJO-UHFFFAOYSA-N 517375 US11104690, Example 172-A Diacylglycerol O-acyltransferase 2 Homo sapiens 39.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517375 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517375&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678381 461603415 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090566 Clc1ccc(nc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C23H18Cl2N4O3S/c24-15-6-8-21(26-12-15)29-20-11-14(23(30)27-16-9-10-33(31,32)13-16)5-7-18(20)22(28-29)17-3-1-2-4-19(17)25/h1-8,11-12,16H,9-10,13H2,(H,27,30) XQDXWMVGJKQTMJ-UHFFFAOYSA-N 517376 US11104690, Example 173-A::3-(2-chlorophenyl)-1-(5- chloropyridin-2-yl)-N-(1,1- dioxidotetrahydrothiophen-3-yl)-1H- indazole-6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 23.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517376 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517376&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678382 461603416 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090567 C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccccn3)c2c1)-c1ccccc1Cl |r| InChI=1S/C24H21ClN4O3S/c1-24(11-13-33(31,32)15-24)27-23(30)16-9-10-18-20(14-16)29(21-8-4-5-12-26-21)28-22(18)17-6-2-3-7-19(17)25/h2-10,12,14H,11,13,15H2,1H3,(H,27,30) UQFSEIWUMBHPGG-UHFFFAOYSA-N 517377 US11104690, Example 174-A::3-(2-chlorophenyl)-N-(3-methyl- 1,1-dioxidotetrahydrothiophen-3- yl)-1-pyridin-2-yl-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 71.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517377 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517377&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678383 461603417 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090568 C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccccn3)c2c1)-c1ccccc1Cl |r| InChI=1S/C24H21ClN4O3S/c1-24(11-13-33(31,32)15-24)27-23(30)16-9-10-18-20(14-16)29(21-8-4-5-12-26-21)28-22(18)17-6-2-3-7-19(17)25/h2-10,12,14H,11,13,15H2,1H3,(H,27,30) UQFSEIWUMBHPGG-UHFFFAOYSA-N 517378 US11104690, Example 174-B::3-(2-chlorophenyl)-N-(3-methyl- 1,1-dioxidotetrahydrothiophen-3- yl)-1-pyridin-2-yl-1H-indazole-6- carboxamide (enantiomer B) Diacylglycerol O-acyltransferase 2 Homo sapiens 75.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517378 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517378&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678384 461603418 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090569 Clc1ccccc1-c1nn(-c2ccccn2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 InChI=1S/C23H19ClN4O3S/c24-19-6-2-1-5-17(19)22-18-9-8-15(23(29)26-16-10-12-32(30,31)14-16)13-20(18)28(27-22)21-7-3-4-11-25-21/h1-9,11,13,16H,10,12,14H2,(H,26,29) BNIRZYFEULEIAG-UHFFFAOYSA-N 517379 US11104690, Example 175-A::3-(2-chlorophenyl)-N-(1,1- dioxidotetrahydrothiophen-3-yl)-1- pyridin-2-yl-1H-indazole-6- carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 338 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517379 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517379&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522761 461603419 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090570 Fc1ccc(nc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| InChI=1S/C23H18ClFN4O3S/c24-19-4-2-1-3-17(19)22-18-7-5-14(23(30)27-16-9-10-33(31,32)13-16)11-20(18)29(28-22)21-8-6-15(25)12-26-21/h1-8,11-12,16H,9-10,13H2,(H,27,30) JSNYZJOZBLNVQO-UHFFFAOYSA-N 517380 US11104690, Example 176-A::3-(2-chlorophenyl)-N-(1,1- dioxidotetrahydrothiophen-3-yl)-1- (5-fluoropyridin-2-yl)-1H-indazole- 6-carboxamide (enantiomer A) Diacylglycerol O-acyltransferase 2 Homo sapiens 252 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517380 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517380&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678385 461603420 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090571 C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cn3)c2c1)-c1ccccc1Cl |r| InChI=1S/C24H20ClFN4O3S/c1-24(10-11-34(32,33)14-24)28-23(31)15-6-8-18-20(12-15)30(21-9-7-16(26)13-27-21)29-22(18)17-4-2-3-5-19(17)25/h2-9,12-13H,10-11,14H2,1H3,(H,28,31) OASRJZUKIRTQJO-UHFFFAOYSA-N 517381 US11104690, Example 172-B::3-(2-chlorophenyl)-1-(5- fluoropyridin-2-yl)-N-(3-methyl- 1,1-dioxidotetrahydrothiophen-3- yl)-1H-indazole-6-carboxamide (enantiomer B) Diacylglycerol O-acyltransferase 2 Homo sapiens 56.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517381 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517381&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678386 461603421 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090572 Fc1ccc(nc1)-n1nc(-c2cccc(c2)C#N)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1 |r| InChI=1S/C24H18FN5O3S/c25-18-5-7-22(27-13-18)30-21-11-17(24(31)28-19-8-9-34(32,33)14-19)4-6-20(21)23(29-30)16-3-1-2-15(10-16)12-26/h1-7,10-11,13,19H,8-9,14H2,(H,28,31) RRUSJWOBNRLWQG-UHFFFAOYSA-N 517382 US11104690, Example 177-B Diacylglycerol O-acyltransferase 2 Homo sapiens 86.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517382 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517382&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678387 461603422 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090573 C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cn3)c2c1)-c1cccc(c1)C#N |r| InChI=1S/C25H20FN5O3S/c1-25(9-10-35(33,34)15-25)29-24(32)18-5-7-20-21(12-18)31(22-8-6-19(26)14-28-22)30-23(20)17-4-2-3-16(11-17)13-27/h2-8,11-12,14H,9-10,15H2,1H3,(H,29,32) WLTJPIDCFTXTOP-UHFFFAOYSA-N 517383 US11104690, Example 178-B::3-(3-cyanophenyl)-1-(5- fluoropyridin-2-yl)-N-(3-methyl- 1,1-dioxidotetrahydrothiophen-3- yl)-1H-indazole-6-carboxamide (enantiomer B) Diacylglycerol O-acyltransferase 2 Homo sapiens 32.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517383 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517383&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678388 461603423 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090574 CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3cscn3)c2c1)-c1ccccc1Cl |w:8.8| InChI=1S/C22H19ClN4O3S2/c1-22(8-9-32(29,30)12-22)25-21(28)14-6-7-16-18(10-14)27(19-11-31-13-24-19)26-20(16)15-4-2-3-5-17(15)23/h2-7,10-11,13H,8-9,12H2,1H3,(H,25,28) AKEVYIXTRIKHBH-UHFFFAOYSA-N 517384 US11104690, Example 179 Diacylglycerol O-acyltransferase 2 Homo sapiens 285 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517384 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517384&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522102 461603424 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090575 COC(=O)c1cccc(c1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)C1 InChI=1S/C27H24ClN3O5S/c1-27(12-13-37(34,35)16-27)29-25(32)17-10-11-21-23(15-17)31(19-7-5-6-18(14-19)26(33)36-2)30-24(21)20-8-3-4-9-22(20)28/h3-11,14-15H,12-13,16H2,1-2H3,(H,29,32) PJNCDIQEKAVVPU-UHFFFAOYSA-N 517385 US11104690, Example 180::methyl 3-{3-(2- chlorophenyl)-6-[(3-methyl- 1,1- dioxidotetrahydrodioxidotetra- hydrodioxidotetrahydrodioxido- tetrahydro-thiophen-3- yl)carbamoyl]-1H-indazol-1- yl}benzoate (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 222 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517385 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517385&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146230610 461603425 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090576 CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ncc(F)cn3)c2c1)-c1ccccc1Cl InChI=1S/C23H19ClFN5O3S/c1-23(8-9-34(32,33)13-23)28-21(31)14-6-7-17-19(10-14)30(22-26-11-15(25)12-27-22)29-20(17)16-4-2-3-5-18(16)24/h2-7,10-12H,8-9,13H2,1H3,(H,28,31) MMCLTAJGMQXTOB-UHFFFAOYSA-N 517386 US11104690, Example 181::3-(2-chlorophenyl)-1-(5- fluoropyrimidin-2-yl)-N-(3- methyl-1,1- dioxidotetradioxidotetradioxido- tetradioxidotetra- hydrothiophen-3-yl)-1H- indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 391 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517386 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517386&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 146230549 461603426 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090577 CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3nnc(s3)C(F)(F)F)c2c1)-c1ccccc1Cl InChI=1S/C22H17ClF3N5O3S2/c1-21(8-9-36(33,34)11-21)27-18(32)12-6-7-14-16(10-12)31(20-29-28-19(35-20)22(24,25)26)30-17(14)13-4-2-3-5-15(13)23/h2-7,10H,8-9,11H2,1H3,(H,27,32) DUSQUNMWDHNIDN-UHFFFAOYSA-N 517387 US11104690, Example 182::3-(2-chlorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen-3- yl)-1-[5-(trifluoromethyl)- 1,3,4-thiadiazol-2-yl]-1H- indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 371 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517387 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517387&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522644 461603427 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090578 CC(C)(C)c1nnc(s1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)C1 InChI=1S/C25H26ClN5O3S2/c1-24(2,3)22-28-29-23(35-22)31-19-13-15(21(32)27-25(4)11-12-36(33,34)14-25)9-10-17(19)20(30-31)16-7-5-6-8-18(16)26/h5-10,13H,11-12,14H2,1-4H3,(H,27,32) HFEOMXMPHAITAX-UHFFFAOYSA-N 517388 US11104690, Example 183::1-(5-tert-butyl-1,3,4- thiadiazol-2-yl)-3-(2- chlorophenyl)-N-(3-methyl- 1,1- dioxidotetrahydrothiophen-3- yl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 460 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517388 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517388&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522079 461603428 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090579 Cn1ccc(n1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)C1 InChI=1S/C23H22ClN5O3S/c1-23(10-12-33(31,32)14-23)25-22(30)15-7-8-17-19(13-15)29(20-9-11-28(2)26-20)27-21(17)16-5-3-4-6-18(16)24/h3-9,11,13H,10,12,14H2,1-2H3,(H,25,30) RLCUPRCOQTZELY-UHFFFAOYSA-N 517389 US11104690, Example 184::3-(2-chlorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen-3- yl)-1-(1-methyl-1H-pyrazol- 3-yl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 201 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517389 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517389&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522127 461603429 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090580 Cc1ccc(nc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)C1 InChI=1S/C25H23ClN4O3S/c1-16-7-10-22(27-14-16)30-21-13-17(24(31)28-25(2)11-12-34(32,33)15-25)8-9-19(21)23(29-30)18-5-3-4-6-20(18)26/h3-10,13-14H,11-12,15H2,1-2H3,(H,28,31) NRTFUSLUGWNMNG-UHFFFAOYSA-N 517390 US11104690, Example 185::3-(2-chlroophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen-3- yl)-1-(5-methylpyridin-2-yl)- 1H-indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 9.50 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517390 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517390&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522530 461603430 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090581 CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3cccc(CO)n3)c2c1)-c1ccccc1Cl InChI=1S/C25H23ClN4O4S/c1-25(11-12-35(33,34)15-25)28-24(32)16-9-10-19-21(13-16)30(22-8-4-5-17(14-31)27-22)29-23(19)18-6-2-3-7-20(18)26/h2-10,13,31H,11-12,14-15H2,1H3,(H,28,32) UEPLXZUWKAZAGZ-UHFFFAOYSA-N 517391 US11104690, Example 186::3-(2-chlorophenyl)-1-(6- methoxypyridin-2-yl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen-3- yl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 322 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517391 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517391&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 162678389 461603431 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090582 COC(=O)c1ccc(cc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)C1 InChI=1S/C27H24ClN3O5S/c1-27(13-14-37(34,35)16-27)29-25(32)18-9-12-21-23(15-18)31(19-10-7-17(8-11-19)26(33)36-2)30-24(21)20-5-3-4-6-22(20)28/h3-12,15H,13-14,16H2,1-2H3,(H,29,32) DIKUYWCBKNPDHO-UHFFFAOYSA-N 517392 US11104690, Example 187::methyl 4-{3-(2- chlorophenyl)-6-[(3-methyl- 1,1- dioxidotetrahydrothiophen-3- yl)carbamoyl]-1H-indazol-1- yl}benzoate (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 644 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517392&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522546 461603432 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090583 CCOC(=O)c1coc(n1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)C1 InChI=1S/C25H23ClN4O6S/c1-3-35-23(32)19-13-36-24(27-19)30-20-12-15(22(31)28-25(2)10-11-37(33,34)14-25)8-9-17(20)21(29-30)16-6-4-5-7-18(16)26/h4-9,12-13H,3,10-11,14H2,1-2H3,(H,28,31) QYDAVJXXKNPCAX-UHFFFAOYSA-N 517393 US11104690, Example 188::ethyl 2-{3-(2-chlorophenyl)- 6-[(3-methyl-1,1- dioxidotetrahydrothiophen-3- yl)carbamoyl]-1H-indazol-1- yl}-1,3-oxazole-4-carboxylate (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 95.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517393 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517393&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522601 461603433 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090584 CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3cccnc3)c2c1)-c1ccccc1Cl InChI=1S/C24H21ClN4O3S/c1-24(10-12-33(31,32)15-24)27-23(30)16-8-9-19-21(13-16)29(17-5-4-11-26-14-17)28-22(19)18-6-2-3-7-20(18)25/h2-9,11,13-14H,10,12,15H2,1H3,(H,27,30) XVASZAIHUPPLPJ-UHFFFAOYSA-N 517394 US11104690, Example 189::3-(2-chlorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen-3- yl)-1-pyridin-3-yl-1H- indazole-6-carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 409 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517394 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517394&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522551 461603434 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090585 CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3nnc(s3)C3CC3)c2c1)-c1ccccc1Cl InChI=1S/C24H22ClN5O3S2/c1-24(10-11-35(32,33)13-24)26-21(31)15-8-9-17-19(12-15)30(23-28-27-22(34-23)14-6-7-14)29-20(17)16-4-2-3-5-18(16)25/h2-5,8-9,12,14H,6-7,10-11,13H2,1H3,(H,26,31) IFFJWXXJFYXKIZ-UHFFFAOYSA-N 517395 US11104690, Example 190::3-(2-chlorophenyl)-1-(5- cyclopropyl-1,3,4-thiadiazol- 2-yl)-N-(3-methyl-1,1- dioxidotetrahydrothiophen-3- yl)-1H-indazole-6- carboxamide (racemic) Diacylglycerol O-acyltransferase 2 Homo sapiens 45.0 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517395 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517395&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522138 461603435 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5 1090586 CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(C3CCCCO3)c2c1)-c1ccccc1Cl |w:8.8,17.18| InChI=1S/C24H26ClN3O4S/c1-24(11-13-33(30,31)15-24)26-23(29)16-9-10-18-20(14-16)28(21-8-4-5-12-32-21)27-22(18)17-6-2-3-7-19(17)25/h2-3,6-7,9-10,14,21H,4-5,8,11-13,15H2,1H3,(H,26,29) ZAQJEJZNIZCGMH-UHFFFAOYSA-N 517396 US11104690, Example 191 Diacylglycerol O-acyltransferase 2 Homo sapiens 182 US Patent 10.7270/Q2ZP497K aid1805895 US11104690 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J 8/31/2021 2/13/2022 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517396 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3385&target=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517396&enzyme=Diacylglycerol+O-acyltransferase+2&column=ki&startPg=0&Increment=50&submit=Search 134522479 461603436 1 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN Diacylglycerol O-acyltransferase 2 DGAT2_HUMAN Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5