BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1523554 CC(C)(O)[C@H](F)CNC(=O)c1cnc2sc(-c3ccccc3)nc2c1NC1CC1 741084 (R)-7-(cyclopropylamino)-N-(2-fluoro-3-hydroxy-3-methylbutyl)-2-phenylthiazolo[5,4-b]pyridine-6-carboxamide::US12304916, Example 1 Interleukin-1 receptor-associated kinase 4 Homo sapiens 39.5 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741084&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590279 518813823 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523555 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3ccccc3)nc12 741085 US12304916, Example 2 Interleukin-1 receptor-associated kinase 4 Homo sapiens 15.5 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741085&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590315 518813824 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523556 CC(C)(O)[C@H](F)CNC(=O)c1cnc2sc(-c3ccccc3)nc2c1NC1CCCC1 741086 US12304916, Example 3 Interleukin-1 receptor-associated kinase 4 Homo sapiens 34.0 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741086&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590347 518813825 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523557 CC(C)(O)[C@H](F)CNC(=O)c1cnc2sc(-c3ccccc3)nc2c1NC1CCOCC1 741087 US12304916, Example 4 Interleukin-1 receptor-associated kinase 4 Homo sapiens 7.90 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741087&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590304 518813826 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523558 CCNc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3ccccc3)nc12 741088 US12304916, Example 5 Interleukin-1 receptor-associated kinase 4 Homo sapiens 46.2 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741088&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590312 518813827 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523559 C[C@H](CO)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3ccccc3)nc12 741089 US12304916, Example 6 Interleukin-1 receptor-associated kinase 4 Homo sapiens 39.8 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741089&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590317 518813828 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523560 C[C@H](CO)Nc1c(C(=O)NCCC(C)(C)O)cnc2sc(-c3ccccc3)nc12 741090 US12304916, Example 7 Interleukin-1 receptor-associated kinase 4 Homo sapiens 172 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741090&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590294 518813829 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523561 C[C@H](CO)Nc1c(C(=O)NCCCN2CCOCC2)cnc2sc(-c3ccccc3)nc12 741091 US12304916, Example 8 Interleukin-1 receptor-associated kinase 4 Homo sapiens 474 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741091&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590333 518813830 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523562 N#CCCNC(=O)c1cnc2sc(-c3ccccc3)nc2c1N[C@H](C)CO 741092 US12304916, Example 9 Interleukin-1 receptor-associated kinase 4 Homo sapiens 440 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741092&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590270 518813831 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523563 C[C@H](CO)Nc1c(C(=O)NCCS(C)(=O)=O)cnc2sc(-c3ccccc3)nc12 741093 US12304916, Example 10 Interleukin-1 receptor-associated kinase 4 Homo sapiens 734 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741093&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590282 518813832 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523564 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3cccnc3)nc12 741094 US12304916, Example 11 Interleukin-1 receptor-associated kinase 4 Homo sapiens 12.0 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741094&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590334 518813833 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523565 CC(C)(O)CCNC(=O)c1cnc2sc(-c3cccnc3)nc2c1NC1CCOCC1 741095 US12304916, Example 12 Interleukin-1 receptor-associated kinase 4 Homo sapiens 168 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741095&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590316 518813834 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523566 O=C(NCCN1CCC(O)CC1)c1cnc2sc(-c3cccnc3)nc2c1NC1CCOCC1 741096 US12304916, Example 13 Interleukin-1 receptor-associated kinase 4 Homo sapiens 517 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741096&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590276 518813835 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523567 CC(C)(O)[C@H](F)CNC(=O)c1cnc2sc(-c3cccnc3)nc2c1NC1CCOCC1 741097 US12304916, Example 14 Interleukin-1 receptor-associated kinase 4 Homo sapiens 39.9 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741097&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590272 518813836 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523568 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(Nc3ccc(-n4cccn4)cc3)nc12 741098 US12304916, Example 15 Interleukin-1 receptor-associated kinase 4 Homo sapiens 2380 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741098&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590292 518813837 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523569 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(Nc3cccnc3)nc12 741099 US12304916, Example 16 Interleukin-1 receptor-associated kinase 4 Homo sapiens 124 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741099&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590277 518813838 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523570 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(Nc3ccc(S(C)(=O)=O)cc3)nc12 741100 US12304916, Example 17 Interleukin-1 receptor-associated kinase 4 Homo sapiens 797 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741100&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590346 518813839 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523571 CC(C)Nc2c(C(=O)NCCC(F)(F)F)cnc3sc(c1cccnc1)nc23 741101 US12304916, Example 18 Interleukin-1 receptor-associated kinase 4 Homo sapiens 323 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741101&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590280 518813840 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523572 CC(C)Nc1c(C(=O)NCCC2CC2)cnc2sc(-c3cccnc3)nc12 741102 US12304916, Example 19 Interleukin-1 receptor-associated kinase 4 Homo sapiens 72.6 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741102&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590281 518813841 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523573 CC(=O)O[C@H]1CC[C@H](NC(=O)c2cnc3sc(-c4cccnc4)nc3c2NC(C)C)CC1 741103 US12304916, Example 20 Interleukin-1 receptor-associated kinase 4 Homo sapiens 12.3 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741103&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590350 518813842 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523574 CC(C)Nc1c(cnc2sc(cc12)-c1cn[nH]c1)C(=O)NC[C@@H](F)C(C)(C)O |r| InChI=1S/C19H24FN5O2S/c1-10(2)25-16-12-5-14(11-6-23-24-7-11)28-18(12)22-8-13(16)17(26)21-9-15(20)19(3,4)27/h5-8,10,15,27H,9H2,1-4H3,(H,21,26)(H,22,25)(H,23,24) IAAHHXMCVPRARJ-UHFFFAOYSA-N 50563729 CHEMBL4749904::US12304916, Example 21 Interleukin-1 receptor-associated kinase 4 Homo sapiens 2.40 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563729&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590300 461684067 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523575 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3cccnc3)cc12 741105 US12304916, Example 22 Interleukin-1 receptor-associated kinase 4 Homo sapiens 5.30 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741105&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590307 518813844 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523576 CC(C)Nc1c(cnc2sc(cc12)-c1ccncc1)C(=O)NC[C@@H](F)C(C)(C)O |r| InChI=1S/C21H25FN4O2S/c1-12(2)26-18-14-9-16(13-5-7-23-8-6-13)29-20(14)25-10-15(18)19(27)24-11-17(22)21(3,4)28/h5-10,12,17,28H,11H2,1-4H3,(H,24,27)(H,25,26) MJJCLSMARNVULZ-UHFFFAOYSA-N 50563728 CHEMBL4756721::US12304916, Example 23 Interleukin-1 receptor-associated kinase 4 Homo sapiens 4.80 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563728 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563728&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590273 461684066 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523577 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3cccc(C#N)c3)cc12 741107 US12304916, Example 24 Interleukin-1 receptor-associated kinase 4 Homo sapiens 16.8 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741107&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590308 518813846 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523578 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3ccc(C#N)nc3)cc12 741108 US12304916, Example 25 Interleukin-1 receptor-associated kinase 4 Homo sapiens 18.9 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741108&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590349 518813847 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523579 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3ccc4nccn4c3)cc12 741109 US12304916, Example 26 Interleukin-1 receptor-associated kinase 4 Homo sapiens 27.7 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741109&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590254 518813848 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523580 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3cncs3)cc12 741110 US12304916, Example 27 Interleukin-1 receptor-associated kinase 4 Homo sapiens 2.00 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741110&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590310 518813849 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523581 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3c[nH]c4ncc(F)cc34)cc12 741111 US12304916, Example 28 Interleukin-1 receptor-associated kinase 4 Homo sapiens 75.6 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741111&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590303 518813850 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523582 CC(C)CCNC(=O)c1cnc2sc(-c3ccncc3)cc2c1NC(C)C 741112 US12304916, Example 29 Interleukin-1 receptor-associated kinase 4 Homo sapiens 12.9 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741112&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590323 518813851 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523583 CC(C)CCNC(=O)c1cnc2sc(-c3cncs3)cc2c1NC(C)C 741113 US12304916, Example 30 Interleukin-1 receptor-associated kinase 4 Homo sapiens 7.50 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741113&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590288 518813852 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523584 CC(C)CCNC(=O)c1cnc2sc(-c3cccnc3)cc2c1NC(C)C 741114 US12304916, Example 31 Interleukin-1 receptor-associated kinase 4 Homo sapiens 35.1 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741114&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590318 518813853 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523585 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3ccnnc3)cc12 741115 US12304916, Example 32 Interleukin-1 receptor-associated kinase 4 Homo sapiens 10.3 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741115&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590319 518813854 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523586 CC(C)CCNC(=O)c1cnc2sc(-c3ccnnc3)cc2c1NC(C)C 741116 US12304916, Example 33 Interleukin-1 receptor-associated kinase 4 Homo sapiens 29.0 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741116&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590340 518813855 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523587 COCCNC(=O)c1cnc2sc(-c3cncs3)cc2c1NC(C)C 741117 US12304916, Example 34 Interleukin-1 receptor-associated kinase 4 Homo sapiens 30.0 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741117&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590305 518813856 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523588 Cc1cc(CNC(=O)c2cnc3sc(-c4cncs4)cc3c2NC(C)C)on1 741118 US12304916, Example 35 Interleukin-1 receptor-associated kinase 4 Homo sapiens 59.7 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741118&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590269 518813857 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523589 CC(C)Nc1c(C(=O)N[C@H]2CC[C@H](O)CC2)cnc2sc(-c3cncs3)cc12 741119 US12304916, Example 36 Interleukin-1 receptor-associated kinase 4 Homo sapiens 20.6 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741119&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156039808 518813858 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523590 CC(C)Nc1c(C(=O)NCCC2(CO)CC2)cnc2sc(-c3cncs3)cc12 741120 US12304916, Example 37 Interleukin-1 receptor-associated kinase 4 Homo sapiens 384 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741120&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590337 518813859 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523591 CC(C)Nc1c(C(=O)N[C@H]2CC[C@H](N)CC2)cnc2sc(-c3cncs3)cc12 741121 US12304916, Example 38 Interleukin-1 receptor-associated kinase 4 Homo sapiens 12.3 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741121&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156039806 518813860 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523592 CC(C)Nc1c(C(=O)NC(CCO)C2CC2)cnc2sc(-c3cncs3)cc12 741122 US12304916, Example 39 Interleukin-1 receptor-associated kinase 4 Homo sapiens 554 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741122&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590322 518813861 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523593 CC(C)Nc1c(C(=O)N[C@H](C)CCO)cnc2sc(-c3cncs3)cc12 741123 US12304916, Example 40 Interleukin-1 receptor-associated kinase 4 Homo sapiens 126 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741123&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590345 518813862 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523594 CC(C)Nc1c(C(=O)NCc2cocn2)cnc2sc(-c3cncs3)cc12 741124 US12304916, Example 41 Interleukin-1 receptor-associated kinase 4 Homo sapiens 21.6 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741124&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590286 518813863 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523595 CC(C)Nc1c(C(=O)NCc2ncn[nH]2)cnc2sc(-c3cncs3)cc12 741125 US12304916, Example 42 Interleukin-1 receptor-associated kinase 4 Homo sapiens 12.2 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741125&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590327 518813864 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523596 CCOCCNC(=O)c1cnc2sc(-c3cncs3)cc2c1NC(C)C 741126 US12304916, Example 43 Interleukin-1 receptor-associated kinase 4 Homo sapiens 17.1 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741126&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590285 518813865 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523597 CC(C)Nc1c(C(=O)NCCC(C)(C)O)cnc2sc(-c3cncs3)cc12 741127 US12304916, Example 44 Interleukin-1 receptor-associated kinase 4 Homo sapiens 8.20 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741127&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590262 518813866 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523598 CC(C)Nc1c(cnc2sc(cc12)-c1cncs1)C(=O)N[C@H]1CC[C@@H](CC1)NC(C)=O |r,wU:21.23,wD:24.30,(61.28,-2.99,;61.29,-4.53,;62.62,-5.3,;59.96,-5.3,;59.96,-6.84,;58.63,-7.61,;58.63,-9.16,;59.97,-9.93,;61.29,-9.16,;62.77,-9.64,;63.68,-8.38,;62.77,-7.13,;61.3,-7.61,;65.22,-8.38,;66.11,-7.13,;67.57,-7.6,;67.58,-9.14,;66.12,-9.62,;57.3,-6.84,;57.3,-5.3,;55.97,-7.61,;54.63,-6.85,;53.3,-7.61,;51.97,-6.83,;51.97,-5.29,;53.31,-4.53,;54.64,-5.3,;50.64,-4.52,;49.31,-5.28,;47.97,-4.51,;49.3,-6.82,)| InChI=1S/C22H27N5O2S2/c1-12(2)25-20-16-8-18(19-10-23-11-30-19)31-22(16)24-9-17(20)21(29)27-15-6-4-14(5-7-15)26-13(3)28/h8-12,14-15H,4-7H2,1-3H3,(H,24,25)(H,26,28)(H,27,29) KUSFXSFMKTYASC-UHFFFAOYSA-N 50563726 CHEMBL4754408::US12304916, Example 45 Interleukin-1 receptor-associated kinase 4 Homo sapiens 3.70 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563726 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563726&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590341 461684064 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523599 CC(C)Nc1c(C(=O)NCC(C)(C)CO)cnc2sc(-c3cncs3)cc12 741129 US12304916, Example 46 Interleukin-1 receptor-associated kinase 4 Homo sapiens 272 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741129&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590343 518813868 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523600 CC(C)Nc1c(C(=O)NCC2(CO)COC2)cnc2sc(-c3cncs3)cc12 741130 US12304916, Example 47 Interleukin-1 receptor-associated kinase 4 Homo sapiens 215 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741130&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590329 518813869 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523601 C[C@H](CCO)NC(=O)c1cnc2sc(-c3cncs3)cc2c1Nc1cnn(CC(F)F)c1 741131 US12304916, Example 48 Interleukin-1 receptor-associated kinase 4 Homo sapiens 1877 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741131 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741131&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590283 518813870 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523602 O=C(NC1CCC(O)CC1)c1cnc2sc(-c3cncs3)cc2c1Nc1cnn(CC(F)F)c1 741132 US12304916, Example 49 Interleukin-1 receptor-associated kinase 4 Homo sapiens 408 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741132&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156039807 518813871 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523603 COC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc3sc(-c4cncs4)cc3c2NC(C)C)CC1 741133 US12304916, Example 50 Interleukin-1 receptor-associated kinase 4 Homo sapiens 9.30 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741133 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741133&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590266 518813872 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523604 COCCNC(=O)c1cnc2sc(-c3cncs3)cc2c1Nc1cnn(CC(F)F)c1 741134 US12304916, Example 51 Interleukin-1 receptor-associated kinase 4 Homo sapiens 1227 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741134&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590324 518813873 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523605 CC(C)(O)[C@H](F)CNC(=O)c1cnc2sc(-c3cncs3)cc2c1Nc1cnn(CC(F)F)c1 741135 US12304916, Example 52 Interleukin-1 receptor-associated kinase 4 Homo sapiens 72.8 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741135 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741135&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590278 518813874 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523606 CC(C)(O)[C@H](F)CNC(=O)c1cnc2sc(-c3cncs3)cc2c1NC1COC1 741136 US12304916, Example 53 Interleukin-1 receptor-associated kinase 4 Homo sapiens 15.1 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741136&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590265 518813875 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523607 O=C(NC1CCC(O)CC1)c1cnc2sc(-c3cncs3)cc2c1NC1COC1 741137 US12304916, Example 54 Interleukin-1 receptor-associated kinase 4 Homo sapiens 193 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741137&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590260 518813876 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523608 O=C(NCc1ncn[nH]1)c1cnc2sc(-c3cncs3)cc2c1NC1COC1 741138 US12304916, Example 55 Interleukin-1 receptor-associated kinase 4 Homo sapiens 200 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741138&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590290 518813877 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523609 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3cnc(N)s3)cc12 741139 US12304916, Example 56 Interleukin-1 receptor-associated kinase 4 Homo sapiens 6.00 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741139&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590289 518813878 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523610 Cc1ncc(-c2cc3c(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cnc3s2)s1 741140 US12304916, Example 57 Interleukin-1 receptor-associated kinase 4 Homo sapiens 8.20 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741140&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590325 518813879 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523611 COc1ncc(-c2cc3c(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cnc3s2)s1 741141 US12304916, Example 58 Interleukin-1 receptor-associated kinase 4 Homo sapiens 53.5 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741141&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590351 518813880 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523612 CC(C)Nc1c(cnc2sc(cc12)-c1ccc(=O)[nH]c1)C(=O)NC[C@@H](F)C(C)(C)O |r| InChI=1S/C21H25FN4O3S/c1-11(2)26-18-13-7-15(12-5-6-17(27)23-8-12)30-20(13)25-9-14(18)19(28)24-10-16(22)21(3,4)29/h5-9,11,16,29H,10H2,1-4H3,(H,23,27)(H,24,28)(H,25,26) NSZUKUCTIKSHPM-UHFFFAOYSA-N 50563727 CHEMBL4762550::US12304916, Example 59 Interleukin-1 receptor-associated kinase 4 Homo sapiens 3.80 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563727&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590271 461684065 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523613 CC(O)CCNC(=O)c1cnc2sc(-c3cncs3)cc2c1NC(C)C 741143 US12304916, Example 60 Interleukin-1 receptor-associated kinase 4 Homo sapiens 10.8 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741143&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590298 518813882 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523614 CC(C)Nc1c(C(=O)NC2CC(O)C2)cnc2sc(-c3cncs3)cc12 741144 US12304916, Example 61 Interleukin-1 receptor-associated kinase 4 Homo sapiens 97.5 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741144&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590344 518813883 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523615 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3cscn3)cc12 741145 US12304916, Example 62 Interleukin-1 receptor-associated kinase 4 Homo sapiens 35.1 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741145&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590314 518813884 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523616 CC(C)Nc1c(C(=O)NCCC2(O)CC(F)(F)C2)cnc2sc(-c3cncs3)cc12 741146 US12304916, Example 63 Interleukin-1 receptor-associated kinase 4 Homo sapiens 5.40 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741146&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590311 518813885 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523617 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3ccc(C#N)nc3)cc12 741147 US12304916, Example 64 Interleukin-1 receptor-associated kinase 4 Homo sapiens 8.50 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741147&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590349 518813886 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523618 CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3cncc(C#N)c3)cc12 741148 US12304916, Example 65 Interleukin-1 receptor-associated kinase 4 Homo sapiens 18.6 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741148&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590295 518813887 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523619 CC(=O)N1CCC(NC(=O)c2cnc3sc(-c4ccc(=O)[nH]c4)cc3c2NC(C)C)CC1 741149 US12304916, Example 66 Interleukin-1 receptor-associated kinase 4 Homo sapiens 37.1 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741149&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590301 518813888 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523620 CC(C)Nc1c(C(=O)NCCCNS(C)(=O)=O)cnc2sc(-c3ccc(=O)[nH]c3)cc12 741150 US12304916, Example 67 Interleukin-1 receptor-associated kinase 4 Homo sapiens 42.8 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741150&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156039866 518813889 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523621 CC(C)Nc1c(C(=O)NCCN2CCS(=O)(=O)CC2)cnc2sc(-c3cncs3)cc12 741151 US12304916, Example 68 Interleukin-1 receptor-associated kinase 4 Homo sapiens 10.9 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741151 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741151&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590352 518813890 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523622 CC(C)Nc1c(C(=O)NCC2CCS(=O)(=O)C2)cnc2sc(-c3cncs3)cc12 741152 US12304916, Example 69 Interleukin-1 receptor-associated kinase 4 Homo sapiens 72.2 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741152 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741152&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590268 518813891 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523623 CC(C)Nc1c(C(=O)NCCC2CCNC2)cnc2sc(-c3ccc(=O)[nH]c3)cc12 741153 US12304916, Example 70 Interleukin-1 receptor-associated kinase 4 Homo sapiens 22.6 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741153 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741153&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590306 518813892 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523624 CC(C)Nc1c(C(=O)NCCc2ccncc2)cnc2sc(-c3ccc(=O)[nH]c3)cc12 741154 US12304916, Example 71 Interleukin-1 receptor-associated kinase 4 Homo sapiens 5.20 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741154 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741154&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590267 518813893 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523625 CC(C)Nc1c(C(=O)NCCc2cccnc2)cnc2sc(-c3ccc(=O)[nH]c3)cc12 741155 US12304916, Example 72 Interleukin-1 receptor-associated kinase 4 Homo sapiens 6.70 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741155 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741155&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590302 518813894 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523626 CC(C)Nc1c(C(=O)NCCN2CCS(=O)(=O)CC2)cnc2sc(-c3ccc(=O)[nH]c3)cc12 741156 US12304916, Example 73 Interleukin-1 receptor-associated kinase 4 Homo sapiens 24.2 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741156 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741156&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590274 518813895 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523627 CC(C)Nc1c(-n2cc(CCC(C)(C)O)nn2)cnc2sc(-c3cccnc3)cc12 741157 4-(1-(4-(isopropylamino)-2-(pyridin-3-yl)thieno[2,3-b]pyridin-5-yl)-1H-1,2,3-triazol-4-yl)-2-methylbutan-2-ol::US12304916, Example 74 Interleukin-1 receptor-associated kinase 4 Homo sapiens 171 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741157 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741157&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590313 518813896 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523628 CC(C)Nc1c(-n2cc(CCC(C)(C)O)nn2)cnc2sc(-c3ccncc3)cc12 741158 US12304916, Example 75 Interleukin-1 receptor-associated kinase 4 Homo sapiens 44.8 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741158 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741158&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590326 518813897 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523629 CC(C)CCc1cn(-c2cnc3sc(-c4ccncc4)cc3c2NC(C)C)nn1 741159 US12304916, Example 76 Interleukin-1 receptor-associated kinase 4 Homo sapiens 44.1 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741159&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590291 518813898 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523630 CC(C)CCc1nc(-c2cnc3sc(-c4cncs4)cc3c2NC(C)C)n[nH]1 741160 US12304916, Example 77 Interleukin-1 receptor-associated kinase 4 Homo sapiens 289 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741160 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741160&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590338 518813899 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523631 CC(C)Nc1c(-c2cn(CC3CC3)nn2)cnc2sc(-c3cncs3)cc12 741161 US12304916, Example 78 Interleukin-1 receptor-associated kinase 4 Homo sapiens 8.80 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=741161 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=741161&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590255 518813900 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523632 CC(C)Nc1c(cnc2sc(cc12)-c1cncs1)-c1cn(CCCO)nn1 InChI=1S/C18H20N6OS2/c1-11(2)21-17-12-6-15(16-8-19-10-26-16)27-18(12)20-7-13(17)14-9-24(23-22-14)4-3-5-25/h6-11,25H,3-5H2,1-2H3,(H,20,21) PCBDWURYIKEHOP-UHFFFAOYSA-N 50563725 CHEMBL4761018::US12304916, Example 79 Interleukin-1 receptor-associated kinase 4 Homo sapiens 2.30 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563725 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563725&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590355 461684063 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589 1523633 CC(C)Nc1c(cnc2sc(cc12)-c1ccc(=O)[nH]c1)-c1cn(CCCO)nn1 InChI=1S/C20H22N6O2S/c1-12(2)23-19-14-8-17(13-4-5-18(28)21-9-13)29-20(14)22-10-15(19)16-11-26(25-24-16)6-3-7-27/h4-5,8-12,27H,3,6-7H2,1-2H3,(H,21,28)(H,22,23) LFYYHYKITSYIBN-UHFFFAOYSA-N 50563724 CHEMBL4789541::US12304916, Example 80 Interleukin-1 receptor-associated kinase 4 Homo sapiens 5.20 US Patent 10.7270/Q23X8C64 US12304916 Ahmad, S; Li, L; Wu, H; Hynes, J 5/20/2025 9/19/2025 Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563724 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563724&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 155590353 461684062 1 MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP Interleukin-1 receptor-associated kinase 4 IRAK4_HUMAN Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589