BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 729136 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCCCCNC4)cc3)cc21 InChI=1S/C25H28N4O3/c1-29-22-14-19(10-11-23(22)32-25(29)31)18-8-6-17(7-9-18)13-21(15-26)28-24(30)20-5-3-2-4-12-27-16-20/h6-11,14,20-21,27H,2-5,12-13,16H2,1H3,(H,28,30) YOHMWEUGBDNXKK-UHFFFAOYSA-N 793729 US20260055093, Example 1-A::US20260055093, Example Table2.1 Dipeptidyl peptidase 1 Mus musculus 63.4 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793729&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841341 528825192 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729137 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@@](C)(O)CO4)cc3)cc21 InChI=1S/C24H26N4O5/c1-24(31)13-26-12-21(32-14-24)22(29)27-18(11-25)9-15-3-5-16(6-4-15)17-7-8-20-19(10-17)28(2)23(30)33-20/h3-8,10,18,21,26,31H,9,12-14H2,1-2H3,(H,27,29) NGLHYYUHOCWLCE-UHFFFAOYSA-N 793730 US20260055093, Example 2-A::US20260055093, Example Table2.2 Dipeptidyl peptidase 1 Mus musculus 51.7 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793730 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793730&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 176059167 528825193 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729138 CO[C@@]1(C)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C25H28N4O5/c1-25(32-3)14-27-13-22(33-15-25)23(30)28-19(12-26)10-16-4-6-17(7-5-16)18-8-9-21-20(11-18)29(2)24(31)34-21/h4-9,11,19,22,27H,10,13-15H2,1-3H3,(H,28,30) XNLZQUOTUAEZBL-UHFFFAOYSA-N 793731 US20260055093, Example 3-A::US20260055093, Example Table2.3 Dipeptidyl peptidase 1 Mus musculus 130 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793731 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793731&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 177369972 528825194 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729139 CO[C@]1(C)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C25H28N4O5/c1-25(32-3)14-27-13-22(33-15-25)23(30)28-19(12-26)10-16-4-6-17(7-5-16)18-8-9-21-20(11-18)29(2)24(31)34-21/h4-9,11,19,22,27H,10,13-15H2,1-3H3,(H,28,30) XNLZQUOTUAEZBL-UHFFFAOYSA-N 793732 US20260055093, Example 3-B::US20260055093, Example Table2.4 Dipeptidyl peptidase 1 Mus musculus 251 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793732 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793732&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 176059169 528825195 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729140 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H]4CCCCCNC4)cc3)cc21 InChI=1S/C25H28N4O3/c1-29-22-14-19(10-11-23(22)32-25(29)31)18-8-6-17(7-9-18)13-21(15-26)28-24(30)20-5-3-2-4-12-27-16-20/h6-11,14,20-21,27H,2-5,12-13,16H2,1H3,(H,28,30) YOHMWEUGBDNXKK-UHFFFAOYSA-N 757258 US20250223284, Example Table 3.5::US20260055093, Compound Table3.5 Dipeptidyl peptidase 1 Mus musculus 54.0 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757258 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757258&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841274 520667525 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729141 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCCO4)cc3)cc21 InChI=1S/C24H26N4O4/c1-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-2-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29) UHJRTXVHKNNEGL-UHFFFAOYSA-N 757283 US20250223284, Example Table 3.30::US20260055093, Compound Table3.30 Dipeptidyl peptidase 1 Mus musculus 41.4 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757283 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757283&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841106 520667550 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729142 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@](C)(O)CO4)cc3)cc21 InChI=1S/C24H26N4O5/c1-24(31)13-26-12-21(32-14-24)22(29)27-18(11-25)9-15-3-5-16(6-4-15)17-7-8-20-19(10-17)28(2)23(30)33-20/h3-8,10,18,21,26,31H,9,12-14H2,1-2H3,(H,27,29) NGLHYYUHOCWLCE-UHFFFAOYSA-N 757262 US20250223284, Example Table 3.9::US20260055093, Compound Table3.9 Dipeptidyl peptidase 1 Mus musculus 351 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757262 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757262&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 176825564 520667529 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729143 CC[C@@]1(O)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C25H28N4O5/c1-3-25(32)14-27-13-22(33-15-25)23(30)28-19(12-26)10-16-4-6-17(7-5-16)18-8-9-21-20(11-18)29(2)24(31)34-21/h4-9,11,19,22,27,32H,3,10,13-15H2,1-2H3,(H,28,30) XJKQMXOKEYXBJJ-UHFFFAOYSA-N 757243 US20250223284, Example Table 2.8::US20260055093, Compound Table3.13 Dipeptidyl peptidase 1 Mus musculus 36.9 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757243&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841229 520667510 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729144 CC[C@]1(O)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C25H28N4O5/c1-3-25(32)14-27-13-22(33-15-25)23(30)28-19(12-26)10-16-4-6-17(7-5-16)18-8-9-21-20(11-18)29(2)24(31)34-21/h4-9,11,19,22,27,32H,3,10,13-15H2,1-2H3,(H,28,30) XJKQMXOKEYXBJJ-UHFFFAOYSA-N 757244 US20250223284, Example Table 2.9::US20260055093, Compound Table3.14 Dipeptidyl peptidase 1 Mus musculus 4038 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 176825574 520667511 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729145 CC(C)[C@]1(O)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H30N4O5/c1-16(2)26(33)14-28-13-23(34-15-26)24(31)29-20(12-27)10-17-4-6-18(7-5-17)19-8-9-22-21(11-19)30(3)25(32)35-22/h4-9,11,16,20,23,28,33H,10,13-15H2,1-3H3,(H,29,31) UWVVOGMQAHQLEV-UHFFFAOYSA-N 757268 US20250223284, Example Table 3.15::US20260055093, Compound Table3.15 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757268 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757268&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 175611120 520667535 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729146 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCC5(CCO5)CO4)cc3)cc21 InChI=1S/C25H26N4O5/c1-29-20-11-18(6-7-21(20)34-24(29)31)17-4-2-16(3-5-17)10-19(12-26)28-23(30)22-13-27-14-25(15-32-22)8-9-33-25/h2-7,11,19,22,27H,8-10,13-15H2,1H3,(H,28,30) WOVWZPWUDRXQJN-UHFFFAOYSA-N 757246 US20250223284, Example Table 2.11::US20260055093, Compound Table3.25 Dipeptidyl peptidase 1 Mus musculus 4.20 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757246 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841262 520667513 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729147 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@@]5(CCO5)CO4)cc3)cc21 InChI=1S/C25H26N4O5/c1-29-20-11-18(6-7-21(20)34-24(29)31)17-4-2-16(3-5-17)10-19(12-26)28-23(30)22-13-27-14-25(15-32-22)8-9-33-25/h2-7,11,19,22,27H,8-10,13-15H2,1H3,(H,28,30) WOVWZPWUDRXQJN-UHFFFAOYSA-N 757247 US20250223284, Example Table 2.12::US20260055093, Compound Table3.27 Dipeptidyl peptidase 1 Mus musculus 2.36 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757247&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841114 520667514 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729148 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCCO4)cc3)cc21 InChI=1S/C24H26N4O4/c1-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-2-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29) UHJRTXVHKNNEGL-UHFFFAOYSA-N 757283 US20250223284, Example Table 3.30::US20260055093, Compound Table3.30 Dipeptidyl peptidase 1 Mus musculus 33.9 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757283 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757283&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841106 520667550 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729149 CN1CC2(C1)OC(=O)c1ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCCO4)cc3)cc12 InChI=1S/C27H30N4O4/c1-31-16-27(17-31)23-13-20(8-9-22(23)26(33)35-27)19-6-4-18(5-7-19)12-21(14-28)30-25(32)24-15-29-10-2-3-11-34-24/h4-9,13,21,24,29H,2-3,10-12,15-17H2,1H3,(H,30,32) YHGSFHCYCRBMBZ-UHFFFAOYSA-N 757249 US20250223284, Example Table 2.14::US20260055093, Compound Table3.31 Dipeptidyl peptidase 1 Mus musculus 17.8 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757249 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757249&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841204 520667516 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729150 CCO[C@@H]1CCNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H30N4O5/c1-3-33-21-10-11-28-15-24(34-16-21)25(31)29-20(14-27)12-17-4-6-18(7-5-17)19-8-9-23-22(13-19)30(2)26(32)35-23/h4-9,13,20-21,24,28H,3,10-12,15-16H2,1-2H3,(H,29,31) ACHPJEOOSCJZMG-UHFFFAOYSA-N 757292 US20250223284, Example Table 3.39::US20260055093, Compound Table3.39 Dipeptidyl peptidase 1 Mus musculus 6.05 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757292 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757292&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841086 520667559 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729151 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCCCCNC4)c(F)c3)cc21 InChI=1S/C25H27FN4O3/c1-30-22-13-17(8-9-23(22)33-25(30)32)16-6-7-18(21(26)12-16)11-20(14-27)29-24(31)19-5-3-2-4-10-28-15-19/h6-9,12-13,19-20,28H,2-5,10-11,15H2,1H3,(H,29,31) HPEROLLRRNWRDW-UHFFFAOYSA-N 757251 US20250223284, Example Table 2.16::US20260055093, Compound Table3.43 Dipeptidyl peptidase 1 Mus musculus 13.1 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757251 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757251&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841391 520667518 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729152 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H]4CCCCCNC4)c(F)c3)cc21 InChI=1S/C25H27FN4O3/c1-30-22-13-17(8-9-23(22)33-25(30)32)16-6-7-18(21(26)12-16)11-20(14-27)29-24(31)19-5-3-2-4-10-28-15-19/h6-9,12-13,19-20,28H,2-5,10-11,15H2,1H3,(H,29,31) HPEROLLRRNWRDW-UHFFFAOYSA-N 757297 US20250223284, Example Table 3.44::US20260055093, Compound Table3.44 Dipeptidyl peptidase 1 Mus musculus 148 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757297 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757297&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841063 520667564 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729153 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CCCCCNC4)cc3)cc21 InChI=1S/C25H28N4O3/c1-29-22-14-19(10-11-23(22)32-25(29)31)18-8-6-17(7-9-18)13-21(15-26)28-24(30)20-5-3-2-4-12-27-16-20/h6-11,14,20-21,27H,2-5,12-13,16H2,1H3,(H,28,30) YOHMWEUGBDNXKK-UHFFFAOYSA-N 757253 US20250223284, Example Table 2.18::US20260055093, Compound Table3.45 Dipeptidyl peptidase 1 Mus musculus 629 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757253 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757253&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841028 520667520 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729154 CCO[C@@]1(C)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H30N4O5/c1-4-34-26(2)15-28-14-23(33-16-26)24(31)29-20(13-27)11-17-5-7-18(8-6-17)19-9-10-22-21(12-19)30(3)25(32)35-22/h5-10,12,20,23,28H,4,11,14-16H2,1-3H3,(H,29,31) DBFAGNUFXNUGIB-UHFFFAOYSA-N 757254 US20250223284, Example Table 2.19::US20260055093, Compound Table3.46 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757254 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757254&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 175611094 520667521 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729155 CCO[C@]1(C)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H30N4O5/c1-4-34-26(2)15-28-14-23(33-16-26)24(31)29-20(13-27)11-17-5-7-18(8-6-17)19-9-10-22-21(12-19)30(3)25(32)35-22/h5-10,12,20,23,28H,4,11,14-16H2,1-3H3,(H,29,31) DBFAGNUFXNUGIB-UHFFFAOYSA-N 757255 US20250223284, Example Table 2.20::US20260055093, Compound Table3.47 Dipeptidyl peptidase 1 Mus musculus 1642 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841342 520667522 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729156 CO[C@@H]1CCO[C@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)CNC1 InChI=1S/C25H28N4O5/c1-29-21-12-18(7-8-22(21)34-25(29)31)17-5-3-16(4-6-17)11-19(13-26)28-24(30)23-15-27-14-20(32-2)9-10-33-23/h3-8,12,19-20,23,27H,9-11,14-15H2,1-2H3,(H,28,30) YDEBBRJOEBJXLF-UHFFFAOYSA-N 793749 US20260055093, Example Table2.21 Dipeptidyl peptidase 1 Mus musculus 7.04 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793749 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793749&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841265 528825212 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 729157 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCCCCNC4)cc3)cc21 InChI=1S/C25H28N4O3/c1-29-22-14-19(10-11-23(22)32-25(29)31)18-8-6-17(7-9-18)13-21(15-26)28-24(30)20-5-3-2-4-12-27-16-20/h6-11,14,20-21,27H,2-5,12-13,16H2,1H3,(H,28,30) YOHMWEUGBDNXKK-UHFFFAOYSA-N 793750 US20260055093, Example 1-A::US20260055093, Compound Table3.1 Dipeptidyl peptidase 1 Homo sapiens 72.6 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793750 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793750&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841341 528825213 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729158 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@@](C)(O)CO4)cc3)cc21 InChI=1S/C24H26N4O5/c1-24(31)13-26-12-21(32-14-24)22(29)27-18(11-25)9-15-3-5-16(6-4-15)17-7-8-20-19(10-17)28(2)23(30)33-20/h3-8,10,18,21,26,31H,9,12-14H2,1-2H3,(H,27,29) NGLHYYUHOCWLCE-UHFFFAOYSA-N 793751 US20260055093, Example 2-A::US20260055093, Compound Table3.2 Dipeptidyl peptidase 1 Homo sapiens 39.6 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793751 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793751&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 176059167 528825214 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729159 CO[C@@]1(C)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C25H28N4O5/c1-25(32-3)14-27-13-22(33-15-25)23(30)28-19(12-26)10-16-4-6-17(7-5-16)18-8-9-21-20(11-18)29(2)24(31)34-21/h4-9,11,19,22,27H,10,13-15H2,1-3H3,(H,28,30) XNLZQUOTUAEZBL-UHFFFAOYSA-N 793752 US20260055093, Example 3-A::US20260055093, Compound Table3.3 Dipeptidyl peptidase 1 Homo sapiens 145 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793752 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793752&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 177369972 528825215 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729160 CO[C@]1(C)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C25H28N4O5/c1-25(32-3)14-27-13-22(33-15-25)23(30)28-19(12-26)10-16-4-6-17(7-5-16)18-8-9-21-20(11-18)29(2)24(31)34-21/h4-9,11,19,22,27H,10,13-15H2,1-3H3,(H,28,30) XNLZQUOTUAEZBL-UHFFFAOYSA-N 793753 US20260055093, Compound Table3.4 Dipeptidyl peptidase 1 Homo sapiens 206 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793753 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793753&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 176059169 528825216 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729161 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H]4CCCCCNC4)cc3)cc21 InChI=1S/C25H28N4O3/c1-29-22-14-19(10-11-23(22)32-25(29)31)18-8-6-17(7-9-18)13-21(15-26)28-24(30)20-5-3-2-4-12-27-16-20/h6-11,14,20-21,27H,2-5,12-13,16H2,1H3,(H,28,30) YOHMWEUGBDNXKK-UHFFFAOYSA-N 757258 US20250223284, Example Table 3.5::US20260055093, Compound Table3.5 Dipeptidyl peptidase 1 Homo sapiens 49.8 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757258 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757258&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841274 520667525 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729162 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCCCCNC4)cc3)cc21 InChI=1S/C25H28N4O3/c1-29-22-14-19(10-11-23(22)32-25(29)31)18-8-6-17(7-9-18)13-21(15-26)28-24(30)20-5-3-2-4-12-27-16-20/h6-11,14,20-21,27H,2-5,12-13,16H2,1H3,(H,28,30) YOHMWEUGBDNXKK-UHFFFAOYSA-N 757260 US20250223284, Example Table 3.7::US20260055093, Compound Table3.7 Dipeptidyl peptidase 1 Homo sapiens 85.6 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757260 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757260&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841341 520667527 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729163 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCCCCNC4)cc3)cc21 InChI=1S/C25H28N4O3/c1-29-22-14-19(10-11-23(22)32-25(29)31)18-8-6-17(7-9-18)13-21(15-26)28-24(30)20-5-3-2-4-12-27-16-20/h6-11,14,20-21,27H,2-5,12-13,16H2,1H3,(H,28,30) YOHMWEUGBDNXKK-UHFFFAOYSA-N 757260 US20250223284, Example Table 3.7::US20260055093, Compound Table3.7 Dipeptidyl peptidase 1 Homo sapiens 61.3 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757260 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757260&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841341 520667527 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729164 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCCO4)cc3)cc21 InChI=1S/C24H26N4O4/c1-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-2-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29) UHJRTXVHKNNEGL-UHFFFAOYSA-N 757283 US20250223284, Example Table 3.30::US20260055093, Compound Table3.30 Dipeptidyl peptidase 1 Homo sapiens 25.1 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757283 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757283&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841106 520667550 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729165 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@](C)(O)CO4)cc3)cc21 InChI=1S/C24H26N4O5/c1-24(31)13-26-12-21(32-14-24)22(29)27-18(11-25)9-15-3-5-16(6-4-15)17-7-8-20-19(10-17)28(2)23(30)33-20/h3-8,10,18,21,26,31H,9,12-14H2,1-2H3,(H,27,29) NGLHYYUHOCWLCE-UHFFFAOYSA-N 757262 US20250223284, Example Table 3.9::US20260055093, Compound Table3.9 Dipeptidyl peptidase 1 Homo sapiens 314 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757262 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757262&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 176825564 520667529 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729166 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@@](C)(O)CO4)c(F)c3)cc21 InChI=1S/C24H25FN4O5/c1-24(32)12-27-11-21(33-13-24)22(30)28-17(10-26)7-16-4-3-14(8-18(16)25)15-5-6-20-19(9-15)29(2)23(31)34-20/h3-6,8-9,17,21,27,32H,7,11-13H2,1-2H3,(H,28,30) HLEWKZBNUGJJKT-UHFFFAOYSA-N 757263 US20250223284, Example Table 3.10::US20260055093, Compound Table3.10 Dipeptidyl peptidase 1 Homo sapiens 14.1 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757263 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757263&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841290 520667530 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729167 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@](C)(O)CO4)c(F)c3)cc21 InChI=1S/C24H25FN4O5/c1-24(32)12-27-11-21(33-13-24)22(30)28-17(10-26)7-16-4-3-14(8-18(16)25)15-5-6-20-19(9-15)29(2)23(31)34-20/h3-6,8-9,17,21,27,32H,7,11-13H2,1-2H3,(H,28,30) HLEWKZBNUGJJKT-UHFFFAOYSA-N 757264 US20250223284, Example Table 3.11::US20260055093, Compound Table3.11 Dipeptidyl peptidase 1 Homo sapiens 13.6 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757264 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757264&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841129 520667531 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729168 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCC(O)(C(F)(F)F)CO4)cc3)cc21 InChI=1S/C24H23F3N4O5/c1-31-18-9-16(6-7-19(18)36-22(31)33)15-4-2-14(3-5-15)8-17(10-28)30-21(32)20-11-29-12-23(34,13-35-20)24(25,26)27/h2-7,9,17,20,29,34H,8,11-13H2,1H3,(H,30,32) ZYWHEVTXJWLHAU-UHFFFAOYSA-N 757265 US20250223284, Example Table 3.12::US20260055093, Compound Table3.12 Dipeptidyl peptidase 1 Homo sapiens 3752 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757265 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757265&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841382 520667532 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729169 CC[C@@]1(O)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C25H28N4O5/c1-3-25(32)14-27-13-22(33-15-25)23(30)28-19(12-26)10-16-4-6-17(7-5-16)18-8-9-21-20(11-18)29(2)24(31)34-21/h4-9,11,19,22,27,32H,3,10,13-15H2,1-2H3,(H,28,30) XJKQMXOKEYXBJJ-UHFFFAOYSA-N 757243 US20250223284, Example Table 2.8::US20260055093, Compound Table3.13 Dipeptidyl peptidase 1 Homo sapiens 25.1 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757243&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841229 520667510 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729170 CC[C@]1(O)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C25H28N4O5/c1-3-25(32)14-27-13-22(33-15-25)23(30)28-19(12-26)10-16-4-6-17(7-5-16)18-8-9-21-20(11-18)29(2)24(31)34-21/h4-9,11,19,22,27,32H,3,10,13-15H2,1-2H3,(H,28,30) XJKQMXOKEYXBJJ-UHFFFAOYSA-N 757244 US20250223284, Example Table 2.9::US20260055093, Compound Table3.14 Dipeptidyl peptidase 1 Homo sapiens 2737 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 176825574 520667511 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729171 CC(C)[C@]1(O)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H30N4O5/c1-16(2)26(33)14-28-13-23(34-15-26)24(31)29-20(12-27)10-17-4-6-18(7-5-17)19-8-9-22-21(11-19)30(3)25(32)35-22/h4-9,11,16,20,23,28,33H,10,13-15H2,1-3H3,(H,29,31) UWVVOGMQAHQLEV-UHFFFAOYSA-N 757268 US20250223284, Example Table 3.15::US20260055093, Compound Table3.15 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757268 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757268&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 175611120 520667535 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729172 C=C[C@]1(O)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C25H26N4O5/c1-3-25(32)14-27-13-22(33-15-25)23(30)28-19(12-26)10-16-4-6-17(7-5-16)18-8-9-21-20(11-18)29(2)24(31)34-21/h3-9,11,19,22,27,32H,1,10,13-15H2,2H3,(H,28,30) AVPZDUFDKSTHOS-UHFFFAOYSA-N 757269 US20250223284, Example Table 3.16::US20260055093, Compound Table3.16 Dipeptidyl peptidase 1 Homo sapiens 1470 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757269 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757269&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841032 520667536 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729173 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@](O)(CO)CO4)cc3)cc21 InChI=1S/C24H26N4O6/c1-28-19-9-17(6-7-20(19)34-23(28)31)16-4-2-15(3-5-16)8-18(10-25)27-22(30)21-11-26-12-24(32,13-29)14-33-21/h2-7,9,18,21,26,29,32H,8,11-14H2,1H3,(H,27,30) VQCYMSAVZVABCX-UHFFFAOYSA-N 757270 US20250223284, Example Table 3.17::US20260055093, Compound Table3.17 Dipeptidyl peptidase 1 Homo sapiens 781 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757270 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757270&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841007 520667537 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729174 C=CCC1(O)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H28N4O5/c1-3-10-26(33)15-28-14-23(34-16-26)24(31)29-20(13-27)11-17-4-6-18(7-5-17)19-8-9-22-21(12-19)30(2)25(32)35-22/h3-9,12,20,23,28,33H,1,10-11,14-16H2,2H3,(H,29,31) ZVBBJTVVPKCSPJ-UHFFFAOYSA-N 757271 US20250223284, Example Table 3.18::US20260055093, Compound Table3.18 Dipeptidyl peptidase 1 Homo sapiens 1022 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757271 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757271&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841040 520667538 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729175 CCC[C@]1(O)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H30N4O5/c1-3-10-26(33)15-28-14-23(34-16-26)24(31)29-20(13-27)11-17-4-6-18(7-5-17)19-8-9-22-21(12-19)30(2)25(32)35-22/h4-9,12,20,23,28,33H,3,10-11,14-16H2,1-2H3,(H,29,31) MYVYKPOCQBVQOT-UHFFFAOYSA-N 757272 US20250223284, Example Table 3.19::US20260055093, Compound Table3.19 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757272 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757272&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841070 520667539 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729176 CCC[C@@]1(O)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H30N4O5/c1-3-10-26(33)15-28-14-23(34-16-26)24(31)29-20(13-27)11-17-4-6-18(7-5-17)19-8-9-22-21(12-19)30(2)25(32)35-22/h4-9,12,20,23,28,33H,3,10-11,14-16H2,1-2H3,(H,29,31) MYVYKPOCQBVQOT-UHFFFAOYSA-N 757273 US20250223284, Example Table 3.20::US20260055093, Compound Table3.20 Dipeptidyl peptidase 1 Homo sapiens 769 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757273 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757273&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841045 520667540 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729177 CC(C)CO[C@@]1(C)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C28H34N4O5/c1-18(2)15-36-28(3)16-30-14-25(35-17-28)26(33)31-22(13-29)11-19-5-7-20(8-6-19)21-9-10-24-23(12-21)32(4)27(34)37-24/h5-10,12,18,22,25,30H,11,14-17H2,1-4H3,(H,31,33) LQUOQDFPEIXXND-UHFFFAOYSA-N 757274 US20250223284, Example Table 3.21::US20260055093, Compound Table3.21 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757274 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757274&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841177 520667541 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729178 CC(C)CO[C@]1(C)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C28H34N4O5/c1-18(2)15-36-28(3)16-30-14-25(35-17-28)26(33)31-22(13-29)11-19-5-7-20(8-6-19)21-9-10-24-23(12-21)32(4)27(34)37-24/h5-10,12,18,22,25,30H,11,14-17H2,1-4H3,(H,31,33) LQUOQDFPEIXXND-UHFFFAOYSA-N 757275 US20250223284, Example Table 3.22::US20260055093, Compound Table3.22 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757275 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757275&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841163 520667542 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729179 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCC(O)(Cc5ccccn5)CO4)cc3)cc21 InChI=1S/C29H29N5O5/c1-34-24-13-21(9-10-25(24)39-28(34)36)20-7-5-19(6-8-20)12-23(15-30)33-27(35)26-16-31-17-29(37,18-38-26)14-22-4-2-3-11-32-22/h2-11,13,23,26,31,37H,12,14,16-18H2,1H3,(H,33,35) DDCVQDISELYLBL-UHFFFAOYSA-N 757276 US20250223284, Example Table 3.23::US20260055093, Compound Table3.23 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757276 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757276&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841197 520667543 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729180 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@@](O)(CO)CO4)cc3)cc21 InChI=1S/C24H26N4O6/c1-28-19-9-17(6-7-20(19)34-23(28)31)16-4-2-15(3-5-16)8-18(10-25)27-22(30)21-11-26-12-24(32,13-29)14-33-21/h2-7,9,18,21,26,29,32H,8,11-14H2,1H3,(H,27,30) VQCYMSAVZVABCX-UHFFFAOYSA-N 757277 US20250223284, Example Table 3.24::US20260055093, Compound Table3.24 Dipeptidyl peptidase 1 Homo sapiens 234 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757277 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757277&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841248 520667544 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729181 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCC5(CCO5)CO4)cc3)cc21 InChI=1S/C25H26N4O5/c1-29-20-11-18(6-7-21(20)34-24(29)31)17-4-2-16(3-5-17)10-19(12-26)28-23(30)22-13-27-14-25(15-32-22)8-9-33-25/h2-7,11,19,22,27H,8-10,13-15H2,1H3,(H,28,30) WOVWZPWUDRXQJN-UHFFFAOYSA-N 757246 US20250223284, Example Table 2.11::US20260055093, Compound Table3.25 Dipeptidyl peptidase 1 Homo sapiens 4.20 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757246 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841262 520667513 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729182 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@]5(CCO5)CO4)cc3)cc21 InChI=1S/C25H26N4O5/c1-29-20-11-18(6-7-21(20)34-24(29)31)17-4-2-16(3-5-17)10-19(12-26)28-23(30)22-13-27-14-25(15-32-22)8-9-33-25/h2-7,11,19,22,27H,8-10,13-15H2,1H3,(H,28,30) WOVWZPWUDRXQJN-UHFFFAOYSA-N 757279 US20250223284, Example Table 3.26::US20260055093, Compound Table3.26 Dipeptidyl peptidase 1 Homo sapiens 729 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757279 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757279&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841241 520667546 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729183 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@@]5(CCO5)CO4)cc3)cc21 InChI=1S/C25H26N4O5/c1-29-20-11-18(6-7-21(20)34-24(29)31)17-4-2-16(3-5-17)10-19(12-26)28-23(30)22-13-27-14-25(15-32-22)8-9-33-25/h2-7,11,19,22,27H,8-10,13-15H2,1H3,(H,28,30) WOVWZPWUDRXQJN-UHFFFAOYSA-N 757247 US20250223284, Example Table 2.12::US20260055093, Compound Table3.27 Dipeptidyl peptidase 1 Homo sapiens 3.04 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757247&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841114 520667514 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729184 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCC5(CCCO5)CO4)cc3)cc21 InChI=1S/C26H28N4O5/c1-30-21-12-19(7-8-22(21)35-25(30)32)18-5-3-17(4-6-18)11-20(13-27)29-24(31)23-14-28-15-26(16-33-23)9-2-10-34-26/h3-8,12,20,23,28H,2,9-11,14-16H2,1H3,(H,29,31) JRGOIWPCIKRWIP-UHFFFAOYSA-N 757281 US20250223284, Example Table 3.28::US20260055093, Compound Table3.28 Dipeptidyl peptidase 1 Homo sapiens 95.9 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757281 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757281&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841191 520667548 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729185 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCCC(O)CNC4)cc3)cc21 InChI=1S/C25H28N4O4/c1-29-22-12-18(9-10-23(22)33-25(29)32)17-7-5-16(6-8-17)11-20(13-26)28-24(31)19-3-2-4-21(30)15-27-14-19/h5-10,12,19-21,27,30H,2-4,11,14-15H2,1H3,(H,28,31) GOYWECNVRFCIKZ-UHFFFAOYSA-N 757282 US20250223284, Example Table 3.29::US20260055093, Compound Table3.29 Dipeptidyl peptidase 1 Homo sapiens 230 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757282 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757282&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841122 520667549 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729186 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCCO4)cc3)cc21 InChI=1S/C24H26N4O4/c1-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-2-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29) UHJRTXVHKNNEGL-UHFFFAOYSA-N 757283 US20250223284, Example Table 3.30::US20260055093, Compound Table3.30 Dipeptidyl peptidase 1 Homo sapiens 22.3 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757283 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757283&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841106 520667550 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729187 CN1CC2(C1)OC(=O)c1ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCCO4)cc3)cc12 InChI=1S/C27H30N4O4/c1-31-16-27(17-31)23-13-20(8-9-22(23)26(33)35-27)19-6-4-18(5-7-19)12-21(14-28)30-25(32)24-15-29-10-2-3-11-34-24/h4-9,13,21,24,29H,2-3,10-12,15-17H2,1H3,(H,30,32) YHGSFHCYCRBMBZ-UHFFFAOYSA-N 757249 US20250223284, Example Table 2.14::US20260055093, Compound Table3.31 Dipeptidyl peptidase 1 Homo sapiens 30.9 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757249 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757249&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841204 520667516 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729188 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@@H](O)CCO4)cc3)cc21 InChI=1S/C24H26N4O5/c1-28-20-11-17(6-7-21(20)33-24(28)31)16-4-2-15(3-5-16)10-18(12-25)27-23(30)22-14-26-13-19(29)8-9-32-22/h2-7,11,18-19,22,26,29H,8-10,13-14H2,1H3,(H,27,30) OCJJMMJEGSKPTB-UHFFFAOYSA-N 757285 US20250223284, Example Table 3.32::US20260055093, Compound Table3.32 Dipeptidyl peptidase 1 Homo sapiens 198 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757285 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757285&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841320 520667552 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729189 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCC[C@H](O)CO4)cc3)cc21 InChI=1S/C24H26N4O5/c1-28-20-11-17(6-7-21(20)33-24(28)31)16-4-2-15(3-5-16)10-18(12-25)27-23(30)22-13-26-9-8-19(29)14-32-22/h2-7,11,18-19,22,26,29H,8-10,13-14H2,1H3,(H,27,30) STGKRXKJMDBQAZ-UHFFFAOYSA-N 757286 US20250223284, Example Table 3.33::US20260055093, Compound Table3.33 Dipeptidyl peptidase 1 Homo sapiens 67.4 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757286 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757286&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841210 520667553 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729190 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@@](C)(O)CCO4)cc3)cc21 InChI=1S/C25H28N4O5/c1-25(32)9-10-33-22(14-27-15-25)23(30)28-19(13-26)11-16-3-5-17(6-4-16)18-7-8-21-20(12-18)29(2)24(31)34-21/h3-8,12,19,22,27,32H,9-11,14-15H2,1-2H3,(H,28,30) AVPCISBDLAAJJP-UHFFFAOYSA-N 757287 US20250223284, Example Table 3.34::US20260055093, Compound Table3.34 Dipeptidyl peptidase 1 Homo sapiens 243 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757287 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757287&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841390 520667554 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729191 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNC[C@](C)(O)CCO4)cc3)cc21 InChI=1S/C25H28N4O5/c1-25(32)9-10-33-22(14-27-15-25)23(30)28-19(13-26)11-16-3-5-17(6-4-16)18-7-8-21-20(12-18)29(2)24(31)34-21/h3-8,12,19,22,27,32H,9-11,14-15H2,1-2H3,(H,28,30) AVPCISBDLAAJJP-UHFFFAOYSA-N 757288 US20250223284, Example Table 3.35::US20260055093, Compound Table3.35 Dipeptidyl peptidase 1 Homo sapiens 23.2 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757288 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757288&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841014 520667555 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729192 CCO[C@H]1CCO[C@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)CNC1 InChI=1S/C26H30N4O5/c1-3-33-21-10-11-34-24(16-28-15-21)25(31)29-20(14-27)12-17-4-6-18(7-5-17)19-8-9-23-22(13-19)30(2)26(32)35-23/h4-9,13,20-21,24,28H,3,10-12,15-16H2,1-2H3,(H,29,31) WOHXDIJIWFBWEX-UHFFFAOYSA-N 757289 US20250223284, Example Table 3.36::US20260055093, Compound Table3.36 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757289 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757289&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841235 520667556 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729193 CCO[C@H]1CCNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H30N4O5/c1-3-33-21-10-11-28-15-24(34-16-21)25(31)29-20(14-27)12-17-4-6-18(7-5-17)19-8-9-23-22(13-19)30(2)26(32)35-23/h4-9,13,20-21,24,28H,3,10-12,15-16H2,1-2H3,(H,29,31) ACHPJEOOSCJZMG-UHFFFAOYSA-N 757290 US20250223284, Example Table 3.37::US20260055093, Compound Table3.37 Dipeptidyl peptidase 1 Homo sapiens 457 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757290 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757290&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841113 520667557 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729194 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCC(C)(O)CO4)cc3)cc21 InChI=1S/C25H28N4O5/c1-25(32)9-10-27-14-22(33-15-25)23(30)28-19(13-26)11-16-3-5-17(6-4-16)18-7-8-21-20(12-18)29(2)24(31)34-21/h3-8,12,19,22,27,32H,9-11,14-15H2,1-2H3,(H,28,30) DUSFASGFOWZOIC-UHFFFAOYSA-N 757291 US20250223284, Example Table 3.38::US20260055093, Compound Table3.38 Dipeptidyl peptidase 1 Homo sapiens 2240 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757291 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757291&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841101 520667558 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729195 CCO[C@@H]1CCNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H30N4O5/c1-3-33-21-10-11-28-15-24(34-16-21)25(31)29-20(14-27)12-17-4-6-18(7-5-17)19-8-9-23-22(13-19)30(2)26(32)35-23/h4-9,13,20-21,24,28H,3,10-12,15-16H2,1-2H3,(H,29,31) ACHPJEOOSCJZMG-UHFFFAOYSA-N 757292 US20250223284, Example Table 3.39::US20260055093, Compound Table3.39 Dipeptidyl peptidase 1 Homo sapiens 4.91 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757292 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757292&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841086 520667559 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729196 CCO[C@@H]1CCO[C@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)CNC1 InChI=1S/C26H30N4O5/c1-3-33-21-10-11-34-24(16-28-15-21)25(31)29-20(14-27)12-17-4-6-18(7-5-17)19-8-9-23-22(13-19)30(2)26(32)35-23/h4-9,13,20-21,24,28H,3,10-12,15-16H2,1-2H3,(H,29,31) WOHXDIJIWFBWEX-UHFFFAOYSA-N 757293 US20250223284, Example Table 3.40::US20260055093, Compound Table3.40 Dipeptidyl peptidase 1 Homo sapiens 27.0 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757293 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757293&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841008 520667560 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729197 CO[C@H]1CCO[C@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)CNC1 InChI=1S/C25H28N4O5/c1-29-21-12-18(7-8-22(21)34-25(29)31)17-5-3-16(4-6-17)11-19(13-26)28-24(30)23-15-27-14-20(32-2)9-10-33-23/h3-8,12,19-20,23,27H,9-11,14-15H2,1-2H3,(H,28,30) YDEBBRJOEBJXLF-UHFFFAOYSA-N 757294 US20250223284, Example Table 3.41::US20260055093, Compound Table3.41 Dipeptidyl peptidase 1 Homo sapiens 1141 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757294 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757294&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841203 520667561 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729198 CO[C@H]1CCNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C25H28N4O5/c1-29-21-12-18(7-8-22(21)34-25(29)31)17-5-3-16(4-6-17)11-19(13-26)28-24(30)23-14-27-10-9-20(32-2)15-33-23/h3-8,12,19-20,23,27H,9-11,14-15H2,1-2H3,(H,28,30) ZXWMNOLTKWOKDO-UHFFFAOYSA-N 757295 US20250223284, Example Table 3.42::US20260055093, Compound Table3.49 Dipeptidyl peptidase 1 Homo sapiens 74.7 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757295 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757295&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841146 520667562 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729199 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCCCCNC4)c(F)c3)cc21 InChI=1S/C25H27FN4O3/c1-30-22-13-17(8-9-23(22)33-25(30)32)16-6-7-18(21(26)12-16)11-20(14-27)29-24(31)19-5-3-2-4-10-28-15-19/h6-9,12-13,19-20,28H,2-5,10-11,15H2,1H3,(H,29,31) HPEROLLRRNWRDW-UHFFFAOYSA-N 757251 US20250223284, Example Table 2.16::US20260055093, Compound Table3.43 Dipeptidyl peptidase 1 Homo sapiens 15.8 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757251 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757251&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841391 520667518 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729200 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H]4CCCCCNC4)c(F)c3)cc21 InChI=1S/C25H27FN4O3/c1-30-22-13-17(8-9-23(22)33-25(30)32)16-6-7-18(21(26)12-16)11-20(14-27)29-24(31)19-5-3-2-4-10-28-15-19/h6-9,12-13,19-20,28H,2-5,10-11,15H2,1H3,(H,29,31) HPEROLLRRNWRDW-UHFFFAOYSA-N 757297 US20250223284, Example Table 3.44::US20260055093, Compound Table3.44 Dipeptidyl peptidase 1 Homo sapiens 140 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757297 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757297&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841063 520667564 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729201 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CCCCCNC4)cc3)cc21 InChI=1S/C25H28N4O3/c1-29-22-14-19(10-11-23(22)32-25(29)31)18-8-6-17(7-9-18)13-21(15-26)28-24(30)20-5-3-2-4-12-27-16-20/h6-11,14,20-21,27H,2-5,12-13,16H2,1H3,(H,28,30) YOHMWEUGBDNXKK-UHFFFAOYSA-N 757253 US20250223284, Example Table 2.18::US20260055093, Compound Table3.45 Dipeptidyl peptidase 1 Homo sapiens 603 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757253 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757253&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841028 520667520 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729202 CCO[C@@]1(C)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H30N4O5/c1-4-34-26(2)15-28-14-23(33-16-26)24(31)29-20(13-27)11-17-5-7-18(8-6-17)19-9-10-22-21(12-19)30(3)25(32)35-22/h5-10,12,20,23,28H,4,11,14-16H2,1-3H3,(H,29,31) DBFAGNUFXNUGIB-UHFFFAOYSA-N 757254 US20250223284, Example Table 2.19::US20260055093, Compound Table3.46 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757254 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757254&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 175611094 520667521 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729203 CCO[C@]1(C)CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C26H30N4O5/c1-4-34-26(2)15-28-14-23(33-16-26)24(31)29-20(13-27)11-17-5-7-18(8-6-17)19-9-10-22-21(12-19)30(3)25(32)35-22/h5-10,12,20,23,28H,4,11,14-16H2,1-3H3,(H,29,31) DBFAGNUFXNUGIB-UHFFFAOYSA-N 757255 US20250223284, Example Table 2.20::US20260055093, Compound Table3.47 Dipeptidyl peptidase 1 Homo sapiens 1675 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841342 520667522 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729204 CO[C@@H]1CCO[C@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)CNC1 InChI=1S/C25H28N4O5/c1-29-21-12-18(7-8-22(21)34-25(29)31)17-5-3-16(4-6-17)11-19(13-26)28-24(30)23-15-27-14-20(32-2)9-10-33-23/h3-8,12,19-20,23,27H,9-11,14-15H2,1-2H3,(H,28,30) YDEBBRJOEBJXLF-UHFFFAOYSA-N 793797 US20260055093, Compound Table3.48 Dipeptidyl peptidase 1 Homo sapiens 6.82 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793797 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793797&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841265 528825260 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 729205 CO[C@H]1CCNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C25H28N4O5/c1-29-21-12-18(7-8-22(21)34-25(29)31)17-5-3-16(4-6-17)11-19(13-26)28-24(30)23-14-27-10-9-20(32-2)15-33-23/h3-8,12,19-20,23,27H,9-11,14-15H2,1-2H3,(H,28,30) ZXWMNOLTKWOKDO-UHFFFAOYSA-N 757295 US20250223284, Example Table 3.42::US20260055093, Compound Table3.49 Dipeptidyl peptidase 1 Homo sapiens 17.4 US Patent 10.7270/Q2ZW1RVZ aid1798066 US20260055093 PLAUNT, AJ; CERDAN, A; CIAPETTI, P; GOEGAN, B 2/26/2026 7/9/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=757295 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=757295&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171841146 520667562 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8