BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 729450 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C4CC4)CC3)CC2)C1)C(C)C InChI=1S/C32H44FN7O3/c1-4-40(22(2)3)31(42)26-17-25(33)7-8-27(26)43-29-28(34-21-35-36-29)39-19-32(20-39)11-15-37(16-12-32)18-23-9-13-38(14-10-23)30(41)24-5-6-24/h7-8,17,21-24H,4-6,9-16,18-20H2,1-3H3 KJIDTGWPYYOBAB-UHFFFAOYSA-N 793861 US20260055108, Compound 1 Menin [2-610] 13.6 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793861 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793861&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001319 528825324 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729451 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(C(F)(F)F)cnn4)CC3)CC2)C1)C(C)C InChI=1S/C33H41F4N9O2/c1-4-46(22(2)3)31(47)26-16-25(34)5-6-27(26)48-30-29(38-21-40-42-30)45-19-32(20-45)9-13-43(14-10-32)18-23-7-11-44(12-8-23)28-15-24(17-39-41-28)33(35,36)37/h5-6,15-17,21-23H,4,7-14,18-20H2,1-3H3 SHBPHIWAOUUDIH-UHFFFAOYSA-N 793862 US20260055108, Compound 45 Menin [2-610] 3.90 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793862 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793862&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422903 528825325 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729452 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(OC)cnn4)CC3)CC2)C1)C(C)C InChI=1S/C33H44FN9O3/c1-5-43(23(2)3)32(44)27-16-25(34)6-7-28(27)46-31-30(35-22-37-39-31)42-20-33(21-42)10-14-40(15-11-33)19-24-8-12-41(13-9-24)29-17-26(45-4)18-36-38-29/h6-7,16-18,22-24H,5,8-15,19-21H2,1-4H3 DTODNVZCFKGDKZ-UHFFFAOYSA-N 793863 US20260055108, Compound 89 Menin [2-610] 2.80 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793863 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793863&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422904 528825326 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729453 C#Cc1ccc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C(=O)N(CC)C(C)C)C4)CC2)nn1 InChI=1S/C34H42FN9O2/c1-5-27-8-10-30(39-38-27)42-15-11-25(12-16-42)20-41-17-13-34(14-18-41)21-43(22-34)31-32(40-37-23-36-31)46-29-9-7-26(35)19-28(29)33(45)44(6-2)24(3)4/h1,7-10,19,23-25H,6,11-18,20-22H2,2-4H3 FKQLVGQQSYSKHS-UHFFFAOYSA-N 793864 US20260055108, Compound 134 Menin [2-610] 1.30 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793864 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793864&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422905 528825327 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729454 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C4(C(F)(F)F)CC4)CC3)CC2)C1)C(C)C InChI=1S/C33H43F4N7O3/c1-4-44(22(2)3)29(45)25-17-24(34)5-6-26(25)47-28-27(38-21-39-40-28)43-19-31(20-43)11-15-41(16-12-31)18-23-7-13-42(14-8-23)30(46)32(9-10-32)33(35,36)37/h5-6,17,21-23H,4,7-16,18-20H2,1-3H3 POEFYMWRVVEIEL-UHFFFAOYSA-N 793865 US20260055108, Compound 2 Menin [2-610] 30.0 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793865 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793865&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422906 528825328 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729455 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(Cl)nn4)CC3)CC2)C1)C(C)C InChI=1S/C32H41ClFN9O2/c1-4-43(22(2)3)31(44)25-17-24(34)5-6-26(25)45-30-29(35-21-36-39-30)42-19-32(20-42)11-15-40(16-12-32)18-23-9-13-41(14-10-23)28-8-7-27(33)37-38-28/h5-8,17,21-23H,4,9-16,18-20H2,1-3H3 SRMLKPDHPJAQTI-UHFFFAOYSA-N 793866 US20260055108, Compound 46 Menin [2-610] 1.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793866 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793866&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001329 528825329 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729456 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(OC)c(OC)nn4)CC3)CC2)C1)C(C)C InChI=1S/C34H46FN9O4/c1-6-44(23(2)3)33(45)26-17-25(35)7-8-27(26)48-32-30(36-22-37-39-32)43-20-34(21-43)11-15-41(16-12-34)19-24-9-13-42(14-10-24)29-18-28(46-4)31(47-5)40-38-29/h7-8,17-18,22-24H,6,9-16,19-21H2,1-5H3 KWXJVJQNPAUJCN-UHFFFAOYSA-N 793867 US20260055108, Compound 90 Menin [2-610] 2.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793867 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793867&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422907 528825330 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729457 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCC(c4ccccn4)CC3)CC2)C1)C(C)C InChI=1S/C34H44FN7O2/c1-4-42(24(2)3)33(43)28-19-27(35)12-13-30(28)44-32-31(37-23-38-39-32)41-21-34(22-41)14-17-40(18-15-34)20-25-8-10-26(11-9-25)29-7-5-6-16-36-29/h5-7,12-13,16,19,23-26H,4,8-11,14-15,17-18,20-22H2,1-3H3 WOQXDNODFYXZPW-UHFFFAOYSA-N 793868 US20260055108, Compound 135 Menin [2-610] 55.5 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793868 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793868&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897771 528825331 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729458 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C4CCC4)CC3)CC2)C1)C(C)C InChI=1S/C33H46FN7O3/c1-4-41(23(2)3)32(43)27-18-26(34)8-9-28(27)44-30-29(35-22-36-37-30)40-20-33(21-40)12-16-38(17-13-33)19-24-10-14-39(15-11-24)31(42)25-6-5-7-25/h8-9,18,22-25H,4-7,10-17,19-21H2,1-3H3 JAIOOUQWIKVUIT-UHFFFAOYSA-N 793869 US20260055108, Compound 3 Menin [2-610] 2.40 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793869&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422908 528825332 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729459 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(C#N)nn4)CC3)CC2)C1)C(C)C InChI=1S/C33H41FN10O2/c1-4-44(23(2)3)32(45)27-17-25(34)5-7-28(27)46-31-30(36-22-37-40-31)43-20-33(21-43)11-15-41(16-12-33)19-24-9-13-42(14-10-24)29-8-6-26(18-35)38-39-29/h5-8,17,22-24H,4,9-16,19-21H2,1-3H3 YFMNHEVLDUOURK-UHFFFAOYSA-N 793870 US20260055108, Compound 47 Menin [2-610] 2.60 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793870 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793870&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422909 528825333 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729460 CC(C)n1nccc1-c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(C(F)(F)F)nn4)CC3)CC2)C1 InChI=1S/C33H38F4N10O/c1-22(2)47-26(7-12-40-47)25-17-24(34)3-4-27(25)48-31-30(38-21-39-43-31)46-19-32(20-46)10-15-44(16-11-32)18-23-8-13-45(14-9-23)29-6-5-28(41-42-29)33(35,36)37/h3-7,12,17,21-23H,8-11,13-16,18-20H2,1-2H3 IBFHGOLYKMUGFN-UHFFFAOYSA-N 793871 US20260055108, Compound 91 Menin [2-610] 3.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793871 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793871&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422910 528825334 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729461 N#Cc1ccc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C3=C(F)C(O)CCC3)C4)CC2)nc1 InChI=1S/C34H38F2N8O2/c35-25-5-6-29(27(16-25)26-2-1-3-28(45)31(26)36)46-33-32(39-22-40-41-33)44-20-34(21-44)10-14-42(15-11-34)19-23-8-12-43(13-9-23)30-7-4-24(17-37)18-38-30/h4-7,16,18,22-23,28,45H,1-3,8-15,19-21H2 XNVMDTOYEKNBFF-UHFFFAOYSA-N 793872 US20260055108, Compound 136 Menin [2-610] 184 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793872&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897741 528825335 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729462 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C4CC(C)(C)C4)CC3)CC2)C1)C(C)C InChI=1S/C35H50FN7O3/c1-6-43(24(2)3)33(45)28-17-27(36)7-8-29(28)46-31-30(37-23-38-39-31)42-21-35(22-42)11-15-40(16-12-35)20-25-9-13-41(14-10-25)32(44)26-18-34(4,5)19-26/h7-8,17,23-26H,6,9-16,18-22H2,1-5H3 GZRQHTBQVADRHA-UHFFFAOYSA-N 793873 US20260055108, Compound 4 Menin [2-610] 3.20 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793873 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793873&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422911 528825336 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729463 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(C#N)cnn4)CC3)CC2)C1)C(C)C InChI=1S/C33H41FN10O2/c1-4-44(23(2)3)32(45)27-16-26(34)5-6-28(27)46-31-30(36-22-38-40-31)43-20-33(21-43)9-13-41(14-10-33)19-24-7-11-42(12-8-24)29-15-25(17-35)18-37-39-29/h5-6,15-16,18,22-24H,4,7-14,19-21H2,1-3H3 QMIIMVPTWFKFRE-UHFFFAOYSA-N 793874 US20260055108, Compound 48 Menin [2-610] 4.70 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793874 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793874&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422912 528825337 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729464 COc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3-c3ccnn3C)C4)CC2)nnc1OC InChI=1S/C32H39FN10O3/c1-40-25(6-11-36-40)24-16-23(33)4-5-26(24)46-31-29(34-21-35-38-31)43-19-32(20-43)9-14-41(15-10-32)18-22-7-12-42(13-8-22)28-17-27(44-2)30(45-3)39-37-28/h4-6,11,16-17,21-22H,7-10,12-15,18-20H2,1-3H3 HWKMQUKNYYURQY-UHFFFAOYSA-N 793875 US20260055108, Compound 92 Menin [2-610] 10.9 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793875 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793875&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422913 528825338 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729465 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C4COC4)CC3)CC2)C1)C(C)C InChI=1S/C31H44FN7O3/c1-4-39(22(2)3)30(40)26-15-24(32)5-6-27(26)42-29-28(33-21-34-35-29)38-19-31(20-38)9-13-36(14-10-31)16-23-7-11-37(12-8-23)25-17-41-18-25/h5-6,15,21-23,25H,4,7-14,16-20H2,1-3H3 YVBZIOUPALXQPO-UHFFFAOYSA-N 793876 US20260055108, Compound 137 Menin [2-610] 141 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793876 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793876&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897756 528825339 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729466 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C4COC4)CC3)CC2)C1)C(C)C InChI=1S/C32H44FN7O4/c1-4-40(22(2)3)31(42)26-15-25(33)5-6-27(26)44-29-28(34-21-35-36-29)39-19-32(20-39)9-13-37(14-10-32)16-23-7-11-38(12-8-23)30(41)24-17-43-18-24/h5-6,15,21-24H,4,7-14,16-20H2,1-3H3 GGIOAJBWSFYDQU-UHFFFAOYSA-N 793877 US20260055108, Compound 5 Menin [2-610] 21.3 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793877 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793877&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422914 528825340 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729467 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cnc(C#N)cn4)CC3)CC2)C1)C(C)C InChI=1S/C33H41FN10O2/c1-4-44(23(2)3)32(45)27-15-25(34)5-6-28(27)46-31-30(38-22-39-40-31)43-20-33(21-43)9-13-41(14-10-33)19-24-7-11-42(12-8-24)29-18-36-26(16-35)17-37-29/h5-6,15,17-18,22-24H,4,7-14,19-21H2,1-3H3 BASGIFHTYACOQW-UHFFFAOYSA-N 793878 US20260055108, Compound 49 Menin [2-610] 18.5 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793878&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422915 528825341 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729468 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(OC)c(OC)nn4)CC3)C2)C1)C(C)C InChI=1S/C33H44FN9O4/c1-6-43(22(2)3)32(44)25-15-24(34)7-8-26(25)47-31-29(35-21-36-38-31)42-19-33(20-42)11-14-40(18-33)17-23-9-12-41(13-10-23)28-16-27(45-4)30(46-5)39-37-28/h7-8,15-16,21-23H,6,9-14,17-20H2,1-5H3 ZKCUZMFLIHCNEK-UHFFFAOYSA-N 793879 US20260055108, Compound 93 Menin [2-610] 0.600 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793879&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422916 528825342 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729469 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(Cc4c(C)cc(C)[nH]c4=O)CC3)CC2)C1)C(C)C InChI=1S/C36H49FN8O3/c1-6-45(24(2)3)35(47)29-18-28(37)7-8-31(29)48-34-32(38-23-39-41-34)44-21-36(22-44)11-15-43(16-12-36)19-27-9-13-42(14-10-27)20-30-25(4)17-26(5)40-33(30)46/h7-8,17-18,23-24,27H,6,9-16,19-22H2,1-5H3,(H,40,46) CMFHTAGOMAMKIW-UHFFFAOYSA-N 793880 US20260055108, Compound 138 Menin [2-610] 102 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793880&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422917 528825343 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729470 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C4CC(F)(F)C4)CC3)CC2)C1)C(C)C InChI=1S/C33H44F3N7O3/c1-4-43(22(2)3)31(45)26-15-25(34)5-6-27(26)46-29-28(37-21-38-39-29)42-19-32(20-42)9-13-40(14-10-32)18-23-7-11-41(12-8-23)30(44)24-16-33(35,36)17-24/h5-6,15,21-24H,4,7-14,16-20H2,1-3H3 NXNUJRUJPKNEQR-UHFFFAOYSA-N 793881 US20260055108, Compound 6 Menin [2-610] 6.70 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793881&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422918 528825344 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729471 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(C#N)cn4)CC3)CC2)C1)C(C)C InChI=1S/C34H42FN9O2/c1-4-44(24(2)3)33(45)28-17-27(35)6-7-29(28)46-32-31(38-23-39-40-32)43-21-34(22-43)11-15-41(16-12-34)20-25-9-13-42(14-10-25)30-8-5-26(18-36)19-37-30/h5-8,17,19,23-25H,4,9-16,20-22H2,1-3H3 MZIYYBCMHOKXOS-UHFFFAOYSA-N 793882 US20260055108, Compound 50 Menin [2-610] 5.40 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793882 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793882&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001301 528825345 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729472 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CCC2(CN(CC3CCN(c4cc(OC)c(OC)nn4)CC3)C2)C1)C(C)C InChI=1S/C33H44FN9O4/c1-6-43(22(2)3)32(44)25-15-24(34)7-8-26(25)47-31-29(35-21-36-38-31)42-14-11-33(20-42)18-40(19-33)17-23-9-12-41(13-10-23)28-16-27(45-4)30(46-5)39-37-28/h7-8,15-16,21-23H,6,9-14,17-20H2,1-5H3 QSISHNJQJQBLKI-UHFFFAOYSA-N 793883 US20260055108, Compound 94 Menin [2-610] 0.800 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793883 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793883&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422919 528825346 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729473 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC(C2(N(C)Cc3ccc4[nH]c(C#N)cc4c3C)CC2)C1)C(C)C InChI=1S/C33H37FN8O2/c1-6-42(20(2)3)32(43)27-13-24(34)8-10-29(27)44-31-30(36-19-37-39-31)41-17-23(18-41)33(11-12-33)40(5)16-22-7-9-28-26(21(22)4)14-25(15-35)38-28/h7-10,13-14,19-20,23,38H,6,11-12,16-18H2,1-5H3 PDAPCGCSUKNIES-UHFFFAOYSA-N 793884 US20260055108, Compound 139 Menin [2-610] 6.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793884 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793884&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897764 528825347 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729474 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)CNC4CC4)CC3)CC2)C1)C(C)C InChI=1S/C33H47FN8O3/c1-4-42(23(2)3)32(44)27-17-25(34)5-8-28(27)45-31-30(36-22-37-38-31)41-20-33(21-41)11-15-39(16-12-33)19-24-9-13-40(14-10-24)29(43)18-35-26-6-7-26/h5,8,17,22-24,26,35H,4,6-7,9-16,18-21H2,1-3H3 QOUOTHTWQQNWIJ-UHFFFAOYSA-N 793885 US20260055108, Compound 7 Menin [2-610] 50.2 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793885 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793885&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422920 528825348 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729475 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(C#N)cc4)CC3)CC2)C1)C(C)C InChI=1S/C35H43FN8O2/c1-4-44(25(2)3)34(45)30-19-28(36)7-10-31(30)46-33-32(38-24-39-40-33)43-22-35(23-43)13-17-41(18-14-35)21-27-11-15-42(16-12-27)29-8-5-26(20-37)6-9-29/h5-10,19,24-25,27H,4,11-18,21-23H2,1-3H3 XBZSOLDEOYZFQG-UHFFFAOYSA-N 793886 US20260055108, Compound 51 Menin [2-610] 6.50 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793886&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422921 528825349 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729476 CCOc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C(=O)N(CC)C(C)C)C4)CC2)nnc1OCC InChI=1S/C36H50FN9O4/c1-6-46(25(4)5)35(47)28-19-27(37)9-10-29(28)50-34-32(38-24-39-41-34)45-22-36(23-45)13-17-43(18-14-36)21-26-11-15-44(16-12-26)31-20-30(48-7-2)33(42-40-31)49-8-3/h9-10,19-20,24-26H,6-8,11-18,21-23H2,1-5H3 ONHLKVRZVIECEO-UHFFFAOYSA-N 793887 US20260055108, Compound 95 Menin [2-610] 3.20 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793887&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422922 528825350 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729477 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3(N(C)CCOC)CC3)CC2)C1)C(C)C InChI=1S/C30H44FN7O3/c1-6-38(22(2)3)28(39)24-17-23(31)7-8-25(24)41-27-26(32-21-33-34-27)37-18-29(19-37)11-13-36(14-12-29)20-30(9-10-30)35(4)15-16-40-5/h7-8,17,21-22H,6,9-16,18-20H2,1-5H3 OLJHFYFCJFAZJG-UHFFFAOYSA-N 793888 US20260055108, Compound 140 Menin [2-610] 31.6 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793888&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422923 528825351 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729478 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C4(OC)CC4)CC3)CC2)C1)C(C)C InChI=1S/C33H46FN7O4/c1-5-41(23(2)3)30(42)26-18-25(34)6-7-27(26)45-29-28(35-22-36-37-29)40-20-32(21-40)12-16-38(17-13-32)19-24-8-14-39(15-9-24)31(43)33(44-4)10-11-33/h6-7,18,22-24H,5,8-17,19-21H2,1-4H3 PLTAHSCYPQCIAH-UHFFFAOYSA-N 793889 US20260055108, Compound 8 Menin [2-610] 34.6 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793889&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422924 528825352 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729479 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(C(N)=O)ccn4)CC3)CC2)C1)C(C)C InChI=1S/C34H44FN9O3/c1-4-44(23(2)3)33(46)27-18-26(35)5-6-28(27)47-32-31(38-22-39-40-32)43-20-34(21-43)10-15-41(16-11-34)19-24-8-13-42(14-9-24)29-17-25(30(36)45)7-12-37-29/h5-7,12,17-18,22-24H,4,8-11,13-16,19-21H2,1-3H3,(H2,36,45) QWUXVGRIZGVGHA-UHFFFAOYSA-N 793890 US20260055108, Compound 52 Menin [2-610] 0.900 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793890&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422925 528825353 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729480 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4nnc(OC)cc4OC)CC3)CC2)C1)C(C)C InChI=1S/C34H46FN9O4/c1-6-44(23(2)3)33(45)26-17-25(35)7-8-27(26)48-32-31(36-22-37-40-32)43-20-34(21-43)11-15-41(16-12-34)19-24-9-13-42(14-10-24)30-28(46-4)18-29(47-5)38-39-30/h7-8,17-18,22-24H,6,9-16,19-21H2,1-5H3 FCYAOIQQBGVNFF-UHFFFAOYSA-N 793891 US20260055108, Compound 96 Menin [2-610] 30.0 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793891&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422926 528825354 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729481 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC(C2(N(Cc3ccc4[nH]c(C#N)cc4c3C)C(C)C)CC2)C1)C(C)C InChI=1S/C35H41FN8O2/c1-7-43(21(2)3)34(45)29-14-26(36)9-11-31(29)46-33-32(38-20-39-41-33)42-18-25(19-42)35(12-13-35)44(22(4)5)17-24-8-10-30-28(23(24)6)15-27(16-37)40-30/h8-11,14-15,20-22,25,40H,7,12-13,17-19H2,1-6H3 BAEASSSFHNIBBQ-UHFFFAOYSA-N 793892 US20260055108, Compound 141 Menin [2-610] 153 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793892 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793892&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422927 528825355 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729482 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)COC)CC3)CC2)C1)C(C)C InChI=1S/C31H44FN7O4/c1-5-39(22(2)3)30(41)25-16-24(32)6-7-26(25)43-29-28(33-21-34-35-29)38-19-31(20-38)10-14-36(15-11-31)17-23-8-12-37(13-9-23)27(40)18-42-4/h6-7,16,21-23H,5,8-15,17-20H2,1-4H3 NYPVVUNEAXBHHA-UHFFFAOYSA-N 793893 US20260055108, Compound 9 Menin [2-610] 37.6 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793893 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793893&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422928 528825356 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729483 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3(NCCOC)CC3)CC2)C1)C(C)C InChI=1S/C29H42FN7O3/c1-5-37(21(2)3)27(38)23-16-22(30)6-7-24(23)40-26-25(31-20-33-34-26)36-17-28(18-36)10-13-35(14-11-28)19-29(8-9-29)32-12-15-39-4/h6-7,16,20-21,32H,5,8-15,17-19H2,1-4H3 PMURWDOQDIKOHH-UHFFFAOYSA-N 793894 US20260055108, Compound 53 Menin [2-610] 99.0 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793894 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793894&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422929 528825357 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729484 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(C)c(OC)nn4)CC3)CC2)C1)C(C)C InChI=1S/C34H46FN9O3/c1-6-44(23(2)3)33(45)27-18-26(35)7-8-28(27)47-32-30(36-22-37-39-32)43-20-34(21-43)11-15-41(16-12-34)19-25-9-13-42(14-10-25)29-17-24(4)31(46-5)40-38-29/h7-8,17-18,22-23,25H,6,9-16,19-21H2,1-5H3 UDXMHPDCYTXFIZ-UHFFFAOYSA-N 793895 US20260055108, Compound 97 Menin [2-610] 0.900 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793895 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793895&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422930 528825358 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729485 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CCC(C2(N(C)Cc3ccc4[nH]c(C#N)cc4c3C)CC2)C1)C(C)C InChI=1S/C34H39FN8O2/c1-6-43(21(2)3)33(44)28-15-25(35)8-10-30(28)45-32-31(37-20-38-40-32)42-14-11-24(19-42)34(12-13-34)41(5)18-23-7-9-29-27(22(23)4)16-26(17-36)39-29/h7-10,15-16,20-21,24,39H,6,11-14,18-19H2,1-5H3 XEZFKDWHKFFCHB-UHFFFAOYSA-N 793896 US20260055108, Compound 142 Menin [2-610] 124 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793896 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793896&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422931 528825359 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729486 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C(C)O)CC3)CC2)C1)C(C)C InChI=1S/C31H44FN7O4/c1-5-39(21(2)3)30(42)25-16-24(32)6-7-26(25)43-28-27(33-20-34-35-28)38-18-31(19-38)10-14-36(15-11-31)17-23-8-12-37(13-9-23)29(41)22(4)40/h6-7,16,20-23,40H,5,8-15,17-19H2,1-4H3 OHTRQJYMMQEGNY-UHFFFAOYSA-N 793897 US20260055108, Compound 10 Menin [2-610] 41.7 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793897 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793897&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422932 528825360 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729487 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ncccc4C(N)=O)CC3)CC2)C1)C(C)C InChI=1S/C34H44FN9O3/c1-4-44(23(2)3)33(46)27-18-25(35)7-8-28(27)47-32-31(38-22-39-40-32)43-20-34(21-43)11-16-41(17-12-34)19-24-9-14-42(15-10-24)30-26(29(36)45)6-5-13-37-30/h5-8,13,18,22-24H,4,9-12,14-17,19-21H2,1-3H3,(H2,36,45) PGZPZHNBUNOIGZ-UHFFFAOYSA-N 793898 US20260055108, Compound 54 Menin [2-610] 15.8 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793898 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793898&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422933 528825361 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729488 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4nnc(OC)cc4C)CC3)CC2)C1)C(C)C InChI=1S/C34H46FN9O3/c1-6-44(23(2)3)33(45)27-18-26(35)7-8-28(27)47-32-31(36-22-37-40-32)43-20-34(21-43)11-15-41(16-12-34)19-25-9-13-42(14-10-25)30-24(4)17-29(46-5)38-39-30/h7-8,17-18,22-23,25H,6,9-16,19-21H2,1-5H3 WEGFJMXHOXRGEZ-UHFFFAOYSA-N 793899 US20260055108, Compound 98 Menin [2-610] 7.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793899&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422934 528825362 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729489 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CCC(C2(N(Cc3ccc4[nH]c(C#N)cc4c3C)C(C)C)CC2)C1)C(C)C InChI=1S/C36H43FN8O2/c1-7-44(22(2)3)35(46)30-16-27(37)9-11-32(30)47-34-33(39-21-40-42-34)43-15-12-26(20-43)36(13-14-36)45(23(4)5)19-25-8-10-31-29(24(25)6)17-28(18-38)41-31/h8-11,16-17,21-23,26,41H,7,12-15,19-20H2,1-6H3 GGZJIELDCFDTFA-UHFFFAOYSA-N 793900 US20260055108, Compound 143 Menin [2-610] >1000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793900 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793900&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422935 528825363 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729490 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C4(O)CC4)CC3)CC2)C1)C(C)C InChI=1S/C32H44FN7O4/c1-4-40(22(2)3)29(41)25-17-24(33)5-6-26(25)44-28-27(34-21-35-36-28)39-19-31(20-39)11-15-37(16-12-31)18-23-7-13-38(14-8-23)30(42)32(43)9-10-32/h5-6,17,21-23,43H,4,7-16,18-20H2,1-3H3 LPNRGRWUSYUVDY-UHFFFAOYSA-N 793901 US20260055108, Compound 11 Menin [2-610] 5.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793901&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422936 528825364 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729491 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccn5ncnc5c4)CC3)CC2)C1)C(C)C InChI=1S/C34H43FN10O2/c1-4-44(24(2)3)33(46)28-17-26(35)5-6-29(28)47-32-31(37-22-38-40-32)43-20-34(21-43)10-15-41(16-11-34)19-25-7-12-42(13-8-25)27-9-14-45-30(18-27)36-23-39-45/h5-6,9,14,17-18,22-25H,4,7-8,10-13,15-16,19-21H2,1-3H3 IOETUXCYEWWDIH-UHFFFAOYSA-N 793902 US20260055108, Compound 55 Menin [2-610] 3.50 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793902&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001300 528825365 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729492 COc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C(=O)N3CCCC3)C4)CC2)nnc1OC InChI=1S/C33H42FN9O4/c1-45-27-18-28(37-39-30(27)46-2)41-13-7-23(8-14-41)19-40-15-9-33(10-16-40)20-43(21-33)29-31(38-36-22-35-29)47-26-6-5-24(34)17-25(26)32(44)42-11-3-4-12-42/h5-6,17-18,22-23H,3-4,7-16,19-21H2,1-2H3 AEZFVBCQAHIBFB-UHFFFAOYSA-N 793903 US20260055108, Compound 99 Menin [2-610] 14.7 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793903 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793903&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422937 528825366 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729493 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3(N(C)C(=O)COC)CC3)CC2)C1)C(C)C InChI=1S/C30H42FN7O4/c1-6-38(21(2)3)28(40)23-15-22(31)7-8-24(23)42-27-26(32-20-33-34-27)37-17-29(18-37)11-13-36(14-12-29)19-30(9-10-30)35(4)25(39)16-41-5/h7-8,15,20-21H,6,9-14,16-19H2,1-5H3 LUCKBGDXPVZZGW-UHFFFAOYSA-N 793904 US20260055108, Compound 144 Menin [2-610] 616 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793904 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793904&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897745 528825367 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729494 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C4(C#N)CC4)CC3)CC2)C1)C(C)C InChI=1S/C33H43FN8O3/c1-4-42(23(2)3)30(43)26-17-25(34)5-6-27(26)45-29-28(36-22-37-38-29)41-20-32(21-41)11-15-39(16-12-32)18-24-7-13-40(14-8-24)31(44)33(19-35)9-10-33/h5-6,17,22-24H,4,7-16,18,20-21H2,1-3H3 JPZAXXHOOJOLMQ-UHFFFAOYSA-N 793905 US20260055108, Compound 12 Menin [2-610] 19.8 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793905 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793905&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422938 528825368 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729495 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc5ncnn5c4)CC3)CC2)C1)C(C)C InChI=1S/C34H43FN10O2/c1-4-44(24(2)3)33(46)28-17-26(35)5-7-29(28)47-32-31(37-22-38-40-32)43-20-34(21-43)11-15-41(16-12-34)18-25-9-13-42(14-10-25)27-6-8-30-36-23-39-45(30)19-27/h5-8,17,19,22-25H,4,9-16,18,20-21H2,1-3H3 BNQAOLWJDRICCI-UHFFFAOYSA-N 793906 US20260055108, Compound 56 Menin [2-610] 28.4 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793906 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793906&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422939 528825369 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729496 COc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C(=O)N3CCC[C@H]3C)C4)CC2)nnc1OC InChI=1S/C34H44FN9O4/c1-23-5-4-12-44(23)33(45)26-17-25(35)6-7-27(26)48-32-30(36-22-37-39-32)43-20-34(21-43)10-15-41(16-11-34)19-24-8-13-42(14-9-24)29-18-28(46-2)31(47-3)40-38-29/h6-7,17-18,22-24H,4-5,8-16,19-21H2,1-3H3 MKHXYKFWIXKZTJ-UHFFFAOYSA-N 793907 US20260055108, Compound 100 Menin [2-610] 1.90 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793907 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793907&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422940 528825370 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729497 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC(C2(N(C)Cc3cc(C(N)=O)n(C)n3)CC2)C1)C(C)C InChI=1S/C28H36FN9O3/c1-6-38(17(2)3)27(40)21-11-19(29)7-8-23(21)41-26-25(31-16-32-33-26)37-13-18(14-37)28(9-10-28)35(4)15-20-12-22(24(30)39)36(5)34-20/h7-8,11-12,16-18H,6,9-10,13-15H2,1-5H3,(H2,30,39) BMJBKBQRAORYNP-UHFFFAOYSA-N 793908 US20260055108, Compound 145 Menin [2-610] >1000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793908&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897760 528825371 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729498 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)CC#N)CC3)CC2)C1)C(C)C InChI=1S/C31H41FN8O3/c1-4-40(22(2)3)30(42)25-17-24(32)5-6-26(25)43-29-28(34-21-35-36-29)39-19-31(20-39)10-15-37(16-11-31)18-23-8-13-38(14-9-23)27(41)7-12-33/h5-6,17,21-23H,4,7-11,13-16,18-20H2,1-3H3 ZRNWPRJZUZBVDZ-UHFFFAOYSA-N 793909 US20260055108, Compound 13 Menin [2-610] 14.5 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793909&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422941 528825372 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729499 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccccn4)CC3)CC2)C1)C(C)C InChI=1S/C33H43FN8O2/c1-4-42(24(2)3)32(43)27-19-26(34)8-9-28(27)44-31-30(36-23-37-38-31)41-21-33(22-41)12-17-39(18-13-33)20-25-10-15-40(16-11-25)29-7-5-6-14-35-29/h5-9,14,19,23-25H,4,10-13,15-18,20-22H2,1-3H3 RBIXBZJGLCRSGP-UHFFFAOYSA-N 793910 US20260055108, Compound 57 Menin [2-610] 3.00 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793910 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793910&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897740 528825373 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729500 COc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3-c3ccnn3C(C)C)C4)CC2)nnc1OC InChI=1S/C34H43FN10O3/c1-23(2)45-27(7-12-38-45)26-17-25(35)5-6-28(26)48-33-31(36-22-37-40-33)44-20-34(21-44)10-15-42(16-11-34)19-24-8-13-43(14-9-24)30-18-29(46-3)32(47-4)41-39-30/h5-7,12,17-18,22-24H,8-11,13-16,19-21H2,1-4H3 MUKDJTZXPYQWCV-UHFFFAOYSA-N 793911 US20260055108, Compound 101 Menin [2-610] 0.900 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793911&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422942 528825374 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729501 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC(C2(N(C)Cc3cc(C#N)n(C)n3)CC2)C1)C(C)C InChI=1S/C28H34FN9O2/c1-6-38(18(2)3)27(39)23-11-20(29)7-8-24(23)40-26-25(31-17-32-33-26)37-14-19(15-37)28(9-10-28)35(4)16-21-12-22(13-30)36(5)34-21/h7-8,11-12,17-19H,6,9-10,14-16H2,1-5H3 RUTHYCCNBBDFPT-UHFFFAOYSA-N 793912 US20260055108, Compound 146 Menin [2-610] >1000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793912&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897739 528825375 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729502 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)c4ccccc4F)CC3)CC2)C1)C(C)C InChI=1S/C35H43F2N7O3/c1-4-44(24(2)3)34(46)28-19-26(36)9-10-30(28)47-32-31(38-23-39-40-32)43-21-35(22-43)13-17-41(18-14-35)20-25-11-15-42(16-12-25)33(45)27-7-5-6-8-29(27)37/h5-10,19,23-25H,4,11-18,20-22H2,1-3H3 DMIZTQPPQWZMRB-UHFFFAOYSA-N 793913 US20260055108, Compound 14 Menin [2-610] 29.5 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793913 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793913&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422943 528825376 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729503 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3c(C)cc(C)[nH]c3=O)CC2)C1)C(C)C InChI=1S/C30H38FN7O3/c1-6-38(19(2)3)29(40)23-14-22(31)7-8-25(23)41-28-26(32-18-33-35-28)37-16-30(17-37)9-11-36(12-10-30)15-24-20(4)13-21(5)34-27(24)39/h7-8,13-14,18-19H,6,9-12,15-17H2,1-5H3,(H,34,39) ZCQPYCJITBDLGL-UHFFFAOYSA-N 793914 US20260055108, Compound 58 Menin [2-610] 114 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793914 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793914&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422944 528825377 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729504 COc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3)C4)CC2)nnc1OC InChI=1S/C28H35FN8O3/c1-38-23-15-24(32-34-26(23)39-2)36-11-7-20(8-12-36)16-35-13-9-28(10-14-35)17-37(18-28)25-27(33-31-19-30-25)40-22-5-3-21(29)4-6-22/h3-6,15,19-20H,7-14,16-18H2,1-2H3 PQKFBNFMLGTBOH-UHFFFAOYSA-N 793915 US20260055108, Compound 102 Menin [2-610] 15.9 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793915 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793915&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422945 528825378 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729505 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(CC(O)C(N)=O)CC3)CC2)C1)C(C)C InChI=1S/C31H45FN8O4/c1-4-40(21(2)3)30(43)24-15-23(32)5-6-26(24)44-29-28(34-20-35-36-29)39-18-31(19-39)9-13-38(14-10-31)16-22-7-11-37(12-8-22)17-25(41)27(33)42/h5-6,15,20-22,25,41H,4,7-14,16-19H2,1-3H3,(H2,33,42) HBPDJJNOLUBSNR-UHFFFAOYSA-N 793916 US20260055108, Compound 147 Menin [2-610] 116 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793916&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001302 528825379 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729506 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)c4ccccn4)CC3)CC2)C1)C(C)C InChI=1S/C34H43FN8O3/c1-4-43(24(2)3)32(44)27-19-26(35)8-9-29(27)46-31-30(37-23-38-39-31)42-21-34(22-42)12-17-40(18-13-34)20-25-10-15-41(16-11-25)33(45)28-7-5-6-14-36-28/h5-9,14,19,23-25H,4,10-13,15-18,20-22H2,1-3H3 PKNARGFJJSLSTI-UHFFFAOYSA-N 793917 US20260055108, Compound 15 Menin [2-610] 41.8 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793917 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793917&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422946 528825380 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729507 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc(Cl)nc3)CC2)C1)C(C)C InChI=1S/C28H33ClFN7O2/c1-4-37(19(2)3)27(38)22-13-21(30)6-7-23(22)39-26-25(32-18-33-34-26)36-16-28(17-36)9-11-35(12-10-28)15-20-5-8-24(29)31-14-20/h5-8,13-14,18-19H,4,9-12,15-17H2,1-3H3 VCOWGLHYWBLIND-UHFFFAOYSA-N 793918 US20260055108, Compound 59 Menin [2-610] >1000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793918 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793918&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422947 528825381 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729508 COc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(Cl)cc3)C4)CC2)nnc1OC InChI=1S/C28H35ClN8O3/c1-38-23-15-24(32-34-26(23)39-2)36-11-7-20(8-12-36)16-35-13-9-28(10-14-35)17-37(18-28)25-27(33-31-19-30-25)40-22-5-3-21(29)4-6-22/h3-6,15,19-20H,7-14,16-18H2,1-2H3 LJCVNOXQRGBVLI-UHFFFAOYSA-N 793919 US20260055108, Compound 103 Menin [2-610] 114 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793919 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793919&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422948 528825382 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729509 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4c(cc(C#N)n4CC(O)C(N)=O)c3C)CC2)C1)C(C)C InChI=1S/C36H42FN9O4/c1-5-45(22(2)3)35(49)28-14-25(37)7-9-31(28)50-34-33(40-21-41-42-34)44-19-36(20-44)10-12-43(13-11-36)17-24-6-8-29-27(23(24)4)15-26(16-38)46(29)18-30(47)32(39)48/h6-9,14-15,21-22,30,47H,5,10-13,17-20H2,1-4H3,(H2,39,48) XMZYGFLMFMXFFC-UHFFFAOYSA-N 793920 US20260055108, Compound 148 Menin [2-610] 5.30 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793920&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422949 528825383 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729510 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)c4cnn(C)c4)CC3)CC2)C1)C(C)C InChI=1S/C33H44FN9O3/c1-5-43(23(2)3)32(45)27-16-26(34)6-7-28(27)46-30-29(35-22-36-38-30)42-20-33(21-42)10-14-40(15-11-33)18-24-8-12-41(13-9-24)31(44)25-17-37-39(4)19-25/h6-7,16-17,19,22-24H,5,8-15,18,20-21H2,1-4H3 CMTNLJXSNGLYKP-UHFFFAOYSA-N 793921 US20260055108, Compound 16 Menin [2-610] 75.0 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793921 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793921&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422950 528825384 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729511 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3cnc(OC)c(Cl)c3C)CC2)C1)C(C)C InChI=1S/C30H37ClFN7O3/c1-6-39(19(2)3)29(40)23-13-22(32)7-8-24(23)42-28-26(34-18-35-36-28)38-16-30(17-38)9-11-37(12-10-30)15-21-14-33-27(41-5)25(31)20(21)4/h7-8,13-14,18-19H,6,9-12,15-17H2,1-5H3 USMDFBHFVWSKPF-UHFFFAOYSA-N 793922 US20260055108, Compound 60 Menin [2-610] 574 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793922&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422951 528825385 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729512 COc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)c5c3cnn5C(C)C)C4)CC2)nnc1OC InChI=1S/C32H41FN10O3/c1-21(2)43-28-23(16-36-43)25(6-5-24(28)33)46-31-29(34-20-35-38-31)42-18-32(19-42)9-13-40(14-10-32)17-22-7-11-41(12-8-22)27-15-26(44-3)30(45-4)39-37-27/h5-6,15-16,20-22H,7-14,17-19H2,1-4H3 JXJKRRRZJFRVCH-UHFFFAOYSA-N 793923 US20260055108, Compound 104 Menin [2-610] >1000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793923&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422952 528825386 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729513 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(C(N)=O)cn4)CC3)CC2)C1)C(C)C InChI=1S/C34H44FN9O3/c1-4-44(23(2)3)33(46)27-17-26(35)6-7-28(27)47-32-31(38-22-39-40-32)43-20-34(21-43)11-15-41(16-12-34)19-24-9-13-42(14-10-24)29-8-5-25(18-37-29)30(36)45/h5-8,17-18,22-24H,4,9-16,19-21H2,1-3H3,(H2,36,45) PWMAFHIGKNHGEL-UHFFFAOYSA-N 793924 US20260055108, Compound 149 Menin [2-610] 2.90 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793924 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793924&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 177251952 528825387 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729514 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc(NC(=O)CC#N)cc3C)CC2)C1)C(C)C InChI=1S/C33H39FN8O3/c1-5-42(22(2)3)32(44)27-17-25(34)7-9-28(27)45-31-30(36-21-37-39-31)41-19-33(20-41)11-14-40(15-12-33)18-24-6-8-26(16-23(24)4)38-29(43)10-13-35/h6-9,16-17,21-22H,5,10-12,14-15,18-20H2,1-4H3,(H,38,43) YMHWGFMDBZXTPB-UHFFFAOYSA-N 793925 US20260055108, Compound 17 Menin [2-610] 48.7 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793925 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793925&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422953 528825388 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729515 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc(NCC#N)cc3C)CC2)C1)C(C)C InChI=1S/C32H39FN8O2/c1-5-41(22(2)3)31(42)27-17-25(33)7-9-28(27)43-30-29(36-21-37-38-30)40-19-32(20-40)10-14-39(15-11-32)18-24-6-8-26(16-23(24)4)35-13-12-34/h6-9,16-17,21-22,35H,5,10-11,13-15,18-20H2,1-4H3 RGKLFIDTGZURAH-UHFFFAOYSA-N 793926 US20260055108, Compound 61 Menin [2-610] 89.4 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793926&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422954 528825389 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729516 COc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)c5nn(C(C)C)cc35)C4)CC2)nnc1OC InChI=1S/C32H41FN10O3/c1-21(2)43-17-23-25(6-5-24(33)28(23)39-43)46-31-29(34-20-35-37-31)42-18-32(19-42)9-13-40(14-10-32)16-22-7-11-41(12-8-22)27-15-26(44-3)30(45-4)38-36-27/h5-6,15,17,20-22H,7-14,16,18-19H2,1-4H3 FAZADGHCNCPHMJ-UHFFFAOYSA-N 793927 US20260055108, Compound 105 Menin [2-610] 483 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793927 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793927&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422955 528825390 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729517 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccncc4C(N)=O)CC3)CC2)C1)C(C)C InChI=1S/C34H44FN9O3/c1-4-44(23(2)3)33(46)26-17-25(35)5-6-29(26)47-32-31(38-22-39-40-32)43-20-34(21-43)10-15-41(16-11-34)19-24-8-13-42(14-9-24)28-7-12-37-18-27(28)30(36)45/h5-7,12,17-18,22-24H,4,8-11,13-16,19-21H2,1-3H3,(H2,36,45) OIHADHPFKVSWQS-UHFFFAOYSA-N 793928 US20260055108, Compound 150 Menin [2-610] 41.5 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793928 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793928&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897747 528825391 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729518 C=CC(=O)N1CC(C(=O)N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C(=O)N(CC)C(C)C)C4)CC2)C1 InChI=1S/C35H47FN8O4/c1-5-30(45)42-19-26(20-42)33(46)41-13-9-25(10-14-41)18-40-15-11-35(12-16-40)21-43(22-35)31-32(39-38-23-37-31)48-29-8-7-27(36)17-28(29)34(47)44(6-2)24(3)4/h5,7-8,17,23-26H,1,6,9-16,18-22H2,2-4H3 QGRZYBPBTUZGKS-UHFFFAOYSA-N 793929 US20260055108, Compound 18 Menin [2-610] 14.6 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793929 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793929&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001310 528825392 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729519 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4[nH]ccc4c3)CC2)C1)C(C)C InChI=1S/C31H36FN7O2/c1-4-39(21(2)3)30(40)25-16-24(32)6-8-27(25)41-29-28(34-20-35-36-29)38-18-31(19-38)10-13-37(14-11-31)17-22-5-7-26-23(15-22)9-12-33-26/h5-9,12,15-16,20-21,33H,4,10-11,13-14,17-19H2,1-3H3 OBKOJQFMGOVPFQ-UHFFFAOYSA-N 793930 US20260055108, Compound 62 Menin [2-610] 324 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793930 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793930&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422956 528825393 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729520 COc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C(=O)OC(C)C)C4)CC2)nnc1OC InChI=1S/C32H41FN8O5/c1-21(2)45-31(42)24-15-23(33)5-6-25(24)46-30-28(34-20-35-37-30)41-18-32(19-41)9-13-39(14-10-32)17-22-7-11-40(12-8-22)27-16-26(43-3)29(44-4)38-36-27/h5-6,15-16,20-22H,7-14,17-19H2,1-4H3 QFCLJIONNGMUJQ-UHFFFAOYSA-N 793931 US20260055108, Compound 106 Menin [2-610] 0.900 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793931 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793931&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422957 528825394 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729521 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccnc(C(N)=O)c4)CC3)CC2)C1)C(C)C InChI=1S/C34H44FN9O3/c1-4-44(23(2)3)33(46)27-17-25(35)5-6-29(27)47-32-31(38-22-39-40-32)43-20-34(21-43)10-15-41(16-11-34)19-24-8-13-42(14-9-24)26-7-12-37-28(18-26)30(36)45/h5-7,12,17-18,22-24H,4,8-11,13-16,19-21H2,1-3H3,(H2,36,45) DHQCFPGHYBQYFT-UHFFFAOYSA-N 793932 US20260055108, Compound 151 Menin [2-610] 1.50 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793932 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793932&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422958 528825395 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729522 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C4(C(=O)N(C)C)CC4)CC3)CC2)C1)C(C)C InChI=1S/C35H49FN8O4/c1-6-44(24(2)3)31(45)27-19-26(36)7-8-28(27)48-30-29(37-23-38-39-30)43-21-34(22-43)13-17-41(18-14-34)20-25-9-15-42(16-10-25)33(47)35(11-12-35)32(46)40(4)5/h7-8,19,23-25H,6,9-18,20-22H2,1-5H3 SWHOOZQYTSQQQS-UHFFFAOYSA-N 793933 US20260055108, Compound 19 Menin [2-610] 369 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793933&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897743 528825396 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729523 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4nccn4c3)CC2)C1)C(C)C InChI=1S/C30H35FN8O2/c1-4-39(21(2)3)29(40)24-15-23(31)6-7-25(24)41-28-27(33-20-34-35-28)38-18-30(19-38)9-12-36(13-10-30)16-22-5-8-26-32-11-14-37(26)17-22/h5-8,11,14-15,17,20-21H,4,9-10,12-13,16,18-19H2,1-3H3 OWRDDKKONCBRHL-UHFFFAOYSA-N 793934 US20260055108, Compound 63 Menin [2-610] >1000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793934&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422959 528825397 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729524 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc5c(nn4)OCCO5)CC3)CC2)C1)C(C)C InChI=1S/C34H44FN9O4/c1-4-44(23(2)3)33(45)26-17-25(35)5-6-27(26)48-32-30(36-22-37-39-32)43-20-34(21-43)9-13-41(14-10-34)19-24-7-11-42(12-8-24)29-18-28-31(40-38-29)47-16-15-46-28/h5-6,17-18,22-24H,4,7-16,19-21H2,1-3H3 KGDKYYXRWFBFNT-UHFFFAOYSA-N 793935 US20260055108, Compound 108 Menin [2-610] 21.6 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793935&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422960 528825398 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729525 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4c(cc(C(=O)NC)n4CCO)c3C)CC2)C1)C(C)C InChI=1S/C36H45FN8O4/c1-6-44(23(2)3)35(48)28-17-26(37)8-10-31(28)49-34-32(39-22-40-41-34)43-20-36(21-43)11-13-42(14-12-36)19-25-7-9-29-27(24(25)4)18-30(33(47)38-5)45(29)15-16-46/h7-10,17-18,22-23,46H,6,11-16,19-21H2,1-5H3,(H,38,47) SVUIEHLEMSCGCX-UHFFFAOYSA-N 793936 US20260055108, Compound 152 Menin [2-610] 357 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793936&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001290 528825399 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729526 C=CC(=O)N1CCC(CN2CCC3(CC2)CN(c2ncnnc2Oc2ccc(F)cc2C(=O)N(CC)C(C)C)C3)CC1 InChI=1S/C31H42FN7O3/c1-5-27(40)37-13-9-23(10-14-37)18-36-15-11-31(12-16-36)19-38(20-31)28-29(35-34-21-33-28)42-26-8-7-24(32)17-25(26)30(41)39(6-2)22(3)4/h5,7-8,17,21-23H,1,6,9-16,18-20H2,2-4H3 PVCYYWMGMUXIFB-UHFFFAOYSA-N 793937 US20260055108, Compound 20 Menin [2-610] 98.7 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793937&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001331 528825400 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729527 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4[nH]ncc4c3)CC2)C1)C(C)C InChI=1S/C30H35FN8O2/c1-4-39(20(2)3)29(40)24-14-23(31)6-8-26(24)41-28-27(32-19-34-36-28)38-17-30(18-38)9-11-37(12-10-30)16-21-5-7-25-22(13-21)15-33-35-25/h5-8,13-15,19-20H,4,9-12,16-18H2,1-3H3,(H,33,35) KROGNRYBOGMRDF-UHFFFAOYSA-N 793938 US20260055108, Compound 64 Menin [2-610] 163 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793938&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422961 528825401 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729528 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cnnc(OC)c4)CC3)CC2)C1)C(C)C InChI=1S/C33H44FN9O3/c1-5-43(23(2)3)32(44)27-16-25(34)6-7-28(27)46-31-30(35-22-37-39-31)42-20-33(21-42)10-14-40(15-11-33)19-24-8-12-41(13-9-24)26-17-29(45-4)38-36-18-26/h6-7,16-18,22-24H,5,8-15,19-21H2,1-4H3 LGSQRXLONINDEP-UHFFFAOYSA-N 793939 US20260055108, Compound 109 Menin [2-610] 7.40 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793939&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422962 528825402 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729529 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC(C2(N(C)Cc3ccc4c(cc(C#N)n4CCO)c3C)CC2)C1)C(C)C InChI=1S/C35H41FN8O3/c1-6-43(22(2)3)34(46)29-15-26(36)8-10-31(29)47-33-32(38-21-39-40-33)42-19-25(20-42)35(11-12-35)41(5)18-24-7-9-30-28(23(24)4)16-27(17-37)44(30)13-14-45/h7-10,15-16,21-22,25,45H,6,11-14,18-20H2,1-5H3 XNRZPIZFEZVOER-UHFFFAOYSA-N 793940 US20260055108, Compound 153 Menin [2-610] 5.20 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793940&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422963 528825403 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729530 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)C(F)(F)F)CC3)CC2)C1)C(C)C InChI=1S/C30H39F4N7O3/c1-4-41(20(2)3)27(42)23-15-22(31)5-6-24(23)44-26-25(35-19-36-37-26)40-17-29(18-40)9-13-38(14-10-29)16-21-7-11-39(12-8-21)28(43)30(32,33)34/h5-6,15,19-21H,4,7-14,16-18H2,1-3H3 OJLYMAGCMLVOPV-UHFFFAOYSA-N 793941 US20260055108, Compound 21 Menin [2-610] 97.9 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793941&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422964 528825404 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729531 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4[nH]c(C(=O)NC)cc4c3)CC2)C1)C(C)C InChI=1S/C33H39FN8O3/c1-5-42(21(2)3)32(44)25-16-24(34)7-9-28(25)45-31-29(36-20-37-39-31)41-18-33(19-41)10-12-40(13-11-33)17-22-6-8-26-23(14-22)15-27(38-26)30(43)35-4/h6-9,14-16,20-21,38H,5,10-13,17-19H2,1-4H3,(H,35,43) DOTIGLAKLHYINR-UHFFFAOYSA-N 793942 US20260055108, Compound 65 Menin [2-610] 83.9 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793942&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422965 528825405 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729532 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(OC)c(OC)cn4)CC3)CC2)C1)C(C)C InChI=1S/C35H47FN8O4/c1-6-44(24(2)3)34(45)27-17-26(36)7-8-28(27)48-33-32(38-23-39-40-33)43-21-35(22-43)11-15-41(16-12-35)20-25-9-13-42(14-10-25)31-18-29(46-4)30(47-5)19-37-31/h7-8,17-19,23-25H,6,9-16,20-22H2,1-5H3 CYOXFHAXSRDXCC-UHFFFAOYSA-N 793943 US20260055108, Compound 110 Menin [2-610] 0.700 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793943&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422966 528825406 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729533 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4c(cc(C#N)n4CCO)c3C)CC2)C1)C(C)C InChI=1S/C35H41FN8O3/c1-5-43(23(2)3)34(46)29-16-26(36)7-9-31(29)47-33-32(38-22-39-40-33)42-20-35(21-42)10-12-41(13-11-35)19-25-6-8-30-28(24(25)4)17-27(18-37)44(30)14-15-45/h6-9,16-17,22-23,45H,5,10-15,19-21H2,1-4H3 NIBSYFNHWOCBHH-UHFFFAOYSA-N 793944 US20260055108, Compound 154 Menin [2-610] 0.800 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793944&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422967 528825407 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729534 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(S(C)(=O)=O)CC3)CC2)C1)C(C)C InChI=1S/C29H42FN7O4S/c1-5-37(21(2)3)28(38)24-16-23(30)6-7-25(24)41-27-26(31-20-32-33-27)35-18-29(19-35)10-14-34(15-11-29)17-22-8-12-36(13-9-22)42(4,39)40/h6-7,16,20-22H,5,8-15,17-19H2,1-4H3 QDTJKROCKHTDBQ-UHFFFAOYSA-N 793945 US20260055108, Compound 22 Menin [2-610] 112 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793945&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422968 528825408 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729535 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4[nH]c(C#N)cc4c3C)CC2)C1)C(C)C InChI=1S/C33H37FN8O2/c1-5-42(21(2)3)32(43)27-14-24(34)7-9-29(27)44-31-30(36-20-37-39-31)41-18-33(19-41)10-12-40(13-11-33)17-23-6-8-28-26(22(23)4)15-25(16-35)38-28/h6-9,14-15,20-21,38H,5,10-13,17-19H2,1-4H3 NZDZCEKFUMHFFQ-UHFFFAOYSA-N 793946 US20260055108, Compound 66 Menin [2-610] 1.20 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793946&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422969 528825409 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729536 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cnc(OC)c(OC)c4)CC3)CC2)C1)C(C)C InChI=1S/C35H47FN8O4/c1-6-44(24(2)3)34(45)28-17-26(36)7-8-29(28)48-33-31(38-23-39-40-33)43-21-35(22-43)11-15-41(16-12-35)20-25-9-13-42(14-10-25)27-18-30(46-4)32(47-5)37-19-27/h7-8,17-19,23-25H,6,9-16,20-22H2,1-5H3 OTFXVYCRQOHLQX-UHFFFAOYSA-N 793947 US20260055108, Compound 111 Menin [2-610] 5.20 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793947&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422970 528825410 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729537 Cc1c(CN2CCC3(CC2)CN(c2ncnnc2Oc2ccc(F)cc2)C3)ccc2c1cc(C#N)n2CCO InChI=1S/C29H30FN7O2/c1-20-21(2-7-26-25(20)14-23(15-31)37(26)12-13-38)16-35-10-8-29(9-11-35)17-36(18-29)27-28(34-33-19-32-27)39-24-5-3-22(30)4-6-24/h2-7,14,19,38H,8-13,16-18H2,1H3 OEJCHGXWPPJZFE-UHFFFAOYSA-N 793948 US20260055108, Compound 155 Menin [2-610] 292 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793948&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422971 528825411 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729538 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc(NS(C)(=O)=O)cc3C)CC2)C1)C(C)C InChI=1S/C31H40FN7O4S/c1-6-39(21(2)3)30(40)26-16-24(32)8-10-27(26)43-29-28(33-20-34-35-29)38-18-31(19-38)11-13-37(14-12-31)17-23-7-9-25(15-22(23)4)36-44(5,41)42/h7-10,15-16,20-21,36H,6,11-14,17-19H2,1-5H3 WTVBPBUGPIJJQK-UHFFFAOYSA-N 793949 US20260055108, Compound 23 Menin [2-610] 23.2 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793949&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422972 528825412 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729539 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4oc(C)nc4c3)CC2)C1)C(C)C InChI=1S/C31H36FN7O3/c1-5-39(20(2)3)30(40)24-15-23(32)7-9-26(24)42-29-28(33-19-34-36-29)38-17-31(18-38)10-12-37(13-11-31)16-22-6-8-27-25(14-22)35-21(4)41-27/h6-9,14-15,19-20H,5,10-13,16-18H2,1-4H3 ZBSGXPGXFVVPHI-UHFFFAOYSA-N 793950 US20260055108, Compound 67 Menin [2-610] 512 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793950&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422973 528825413 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729540 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(OC)cn4)CC3)CC2)C1)C(C)C InChI=1S/C34H45FN8O3/c1-5-43(24(2)3)33(44)28-18-26(35)6-8-29(28)46-32-31(37-23-38-39-32)42-21-34(22-42)12-16-40(17-13-34)20-25-10-14-41(15-11-25)30-9-7-27(45-4)19-36-30/h6-9,18-19,23-25H,5,10-17,20-22H2,1-4H3 DAQQIZPTWHVKHN-UHFFFAOYSA-N 793951 US20260055108, Compound 112 Menin [2-610] 5.90 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793951&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422974 528825414 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729541 CCN(C(=O)c1cc(F)ccc1Oc1nnc(NC)nc1N1CC2(CCN(Cc3ccc4c(cc(C#N)n4CCO)c3C)CC2)C1)C(C)C InChI=1S/C36H44FN9O3/c1-6-45(23(2)3)34(48)29-17-26(37)8-10-31(29)49-33-32(40-35(39-5)42-41-33)44-21-36(22-44)11-13-43(14-12-36)20-25-7-9-30-28(24(25)4)18-27(19-38)46(30)15-16-47/h7-10,17-18,23,47H,6,11-16,20-22H2,1-5H3,(H,39,40,42) QFKSPLPOXHJPSE-UHFFFAOYSA-N 793952 US20260055108, Compound 156 Menin [2-610] 43.7 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793952&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422975 528825415 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729542 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)N(C)C)CC3)CC2)C1)C(C)C InChI=1S/C31H45FN8O3/c1-6-40(22(2)3)29(41)25-17-24(32)7-8-26(25)43-28-27(33-21-34-35-28)39-19-31(20-39)11-15-37(16-12-31)18-23-9-13-38(14-10-23)30(42)36(4)5/h7-8,17,21-23H,6,9-16,18-20H2,1-5H3 ZTBPCBTVWMSKTP-UHFFFAOYSA-N 793953 US20260055108, Compound 24 Menin [2-610] 23.0 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793953&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422976 528825416 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729543 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4oc(C)cc4c3)CC2)C1)C(C)C InChI=1S/C32H37FN6O3/c1-5-39(21(2)3)31(40)26-16-25(33)7-9-28(26)42-30-29(34-20-35-36-30)38-18-32(19-38)10-12-37(13-11-32)17-23-6-8-27-24(15-23)14-22(4)41-27/h6-9,14-16,20-21H,5,10-13,17-19H2,1-4H3 JXVSBPVUUILMEJ-UHFFFAOYSA-N 793954 US20260055108, Compound 68 Menin [2-610] 50.2 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793954&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422977 528825417 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729544 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(OC)ccn4)CC3)CC2)C1)C(C)C InChI=1S/C34H45FN8O3/c1-5-43(24(2)3)33(44)28-18-26(35)6-7-29(28)46-32-31(37-23-38-39-32)42-21-34(22-42)11-16-40(17-12-34)20-25-9-14-41(15-10-25)30-19-27(45-4)8-13-36-30/h6-8,13,18-19,23-25H,5,9-12,14-17,20-22H2,1-4H3 FRTGRMCZCVKYHK-UHFFFAOYSA-N 793955 US20260055108, Compound 113 Menin [2-610] 1.90 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793955&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422978 528825418 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729545 COc1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4c(cc(C#N)n4CCO)c3C)CC2)C1 InChI=1S/C30H32FN7O3/c1-20-21(3-5-25-24(20)14-23(15-32)38(25)11-12-39)16-36-9-7-30(8-10-36)17-37(18-30)28-29(35-34-19-33-28)41-26-6-4-22(31)13-27(26)40-2/h3-6,13-14,19,39H,7-12,16-18H2,1-2H3 QPFHUXSLMXDUPE-UHFFFAOYSA-N 793956 US20260055108, Compound 157 Menin [2-610] 305 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793956&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422979 528825419 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729546 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)N(C)c4ccccn4)CC3)CC2)C1)C(C)C InChI=1S/C35H46FN9O3/c1-5-45(25(2)3)33(46)28-20-27(36)9-10-29(28)48-32-31(38-24-39-40-32)44-22-35(23-44)13-18-42(19-14-35)21-26-11-16-43(17-12-26)34(47)41(4)30-8-6-7-15-37-30/h6-10,15,20,24-26H,5,11-14,16-19,21-23H2,1-4H3 ZRCOMRSOMXBBTP-UHFFFAOYSA-N 793957 US20260055108, Compound 25 Menin [2-610] 163 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793957&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422980 528825420 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729547 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4oc(C#N)cc4c3)CC2)C1)C(C)C InChI=1S/C32H34FN7O3/c1-4-40(21(2)3)31(41)26-15-24(33)6-8-28(26)43-30-29(35-20-36-37-30)39-18-32(19-39)9-11-38(12-10-32)17-22-5-7-27-23(13-22)14-25(16-34)42-27/h5-8,13-15,20-21H,4,9-12,17-19H2,1-3H3 RHPQSYVYUHBXOJ-UHFFFAOYSA-N 793958 US20260055108, Compound 69 Menin [2-610] 8.50 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793958&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422981 528825421 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729548 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccnc(OC)c4)CC3)CC2)C1)C(C)C InChI=1S/C34H45FN8O3/c1-5-43(24(2)3)33(44)28-18-26(35)6-7-29(28)46-32-31(37-23-38-39-32)42-21-34(22-42)11-16-40(17-12-34)20-25-9-14-41(15-10-25)27-8-13-36-30(19-27)45-4/h6-8,13,18-19,23-25H,5,9-12,14-17,20-22H2,1-4H3 YQYREGUFTDSAFC-UHFFFAOYSA-N 793959 US20260055108, Compound 114 Menin [2-610] 2.30 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793959&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422982 528825422 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729549 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4c(cc(C(N)=O)n4CCO)c3C)CC2)C1)C(C)C InChI=1S/C35H43FN8O4/c1-5-43(22(2)3)34(47)27-16-25(36)7-9-30(27)48-33-32(38-21-39-40-33)42-19-35(20-42)10-12-41(13-11-35)18-24-6-8-28-26(23(24)4)17-29(31(37)46)44(28)14-15-45/h6-9,16-17,21-22,45H,5,10-15,18-20H2,1-4H3,(H2,37,46) PTWYOWWUUCSMTJ-UHFFFAOYSA-N 793960 US20260055108, Compound 158 Menin [2-610] 212 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793960&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422983 528825423 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729550 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)NC4CC4)CC3)CC2)C1)C(C)C InChI=1S/C32H45FN8O3/c1-4-41(22(2)3)30(42)26-17-24(33)5-8-27(26)44-29-28(34-21-35-37-29)40-19-32(20-40)11-15-38(16-12-32)18-23-9-13-39(14-10-23)31(43)36-25-6-7-25/h5,8,17,21-23,25H,4,6-7,9-16,18-20H2,1-3H3,(H,36,43) FJXOXOZJUKNILC-UHFFFAOYSA-N 793961 US20260055108, Compound 26 Menin [2-610] 0.900 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793961&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897768 528825424 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729551 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4nc(OC)ncc4c3)CC2)C1)C(C)C InChI=1S/C32H37FN8O3/c1-5-41(21(2)3)30(42)25-15-24(33)7-9-27(25)44-29-28(35-20-36-38-29)40-18-32(19-40)10-12-39(13-11-32)17-22-6-8-26-23(14-22)16-34-31(37-26)43-4/h6-9,14-16,20-21H,5,10-13,17-19H2,1-4H3 YTGXLXJBAOBBRG-UHFFFAOYSA-N 793962 US20260055108, Compound 70 Menin [2-610] >1000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793962&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422984 528825425 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729552 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(C#N)nc4)CC3)CC2)C1)C(C)C InChI=1S/C34H42FN9O2/c1-4-44(24(2)3)33(45)29-17-26(35)5-8-30(29)46-32-31(38-23-39-40-32)43-21-34(22-43)11-15-41(16-12-34)20-25-9-13-42(14-10-25)28-7-6-27(18-36)37-19-28/h5-8,17,19,23-25H,4,9-16,20-22H2,1-3H3 NCDYINZSGULQNB-UHFFFAOYSA-N 793963 US20260055108, Compound 115 Menin [2-610] 4.70 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793963&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422985 528825426 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729553 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4c(cc(C(=O)O)n4CCO)c3C)CC2)C1)C(C)C InChI=1S/C35H42FN7O5/c1-5-42(22(2)3)33(45)27-16-25(36)7-9-30(27)48-32-31(37-21-38-39-32)41-19-35(20-41)10-12-40(13-11-35)18-24-6-8-28-26(23(24)4)17-29(34(46)47)43(28)14-15-44/h6-9,16-17,21-22,44H,5,10-15,18-20H2,1-4H3,(H,46,47) WJBBPPPQLZFNBC-UHFFFAOYSA-N 793964 US20260055108, Compound 159 Menin [2-610] 450 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793964&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422986 528825427 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729554 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)NC)CC3)CC2)C1)C(C)C InChI=1S/C30H43FN8O3/c1-5-39(21(2)3)28(40)24-16-23(31)6-7-25(24)42-27-26(33-20-34-35-27)38-18-30(19-38)10-14-36(15-11-30)17-22-8-12-37(13-9-22)29(41)32-4/h6-7,16,20-22H,5,8-15,17-19H2,1-4H3,(H,32,41) NAASXPPKEMKFHR-UHFFFAOYSA-N 793965 US20260055108, Compound 27 Menin [2-610] 5.30 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793965&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422987 528825428 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729555 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4nc(C)ncc4c3)CC2)C1)C(C)C InChI=1S/C32H37FN8O2/c1-5-41(21(2)3)31(42)26-15-25(33)7-9-28(26)43-30-29(35-20-36-38-30)40-18-32(19-40)10-12-39(13-11-32)17-23-6-8-27-24(14-23)16-34-22(4)37-27/h6-9,14-16,20-21H,5,10-13,17-19H2,1-4H3 WJUFEEKMGDOLGY-UHFFFAOYSA-N 793966 US20260055108, Compound 71 Menin [2-610] >1000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793966&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422988 528825429 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729556 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(C#N)cn4)CC3)CC2)C1)C1CC1 InChI=1S/C34H40FN9O2/c1-2-44(27-5-6-27)33(45)28-17-26(35)4-7-29(28)46-32-31(38-23-39-40-32)43-21-34(22-43)11-15-41(16-12-34)20-24-9-13-42(14-10-24)30-8-3-25(18-36)19-37-30/h3-4,7-8,17,19,23-24,27H,2,5-6,9-16,20-22H2,1H3 YWLMWBCSASWOFN-UHFFFAOYSA-N 793967 US20260055108, Compound 116 Menin [2-610] 53.5 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793967&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422989 528825430 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729557 CCN(C(=O)c1cc(F)ccc1Oc1nnc(C)nc1N1CC2(CCN(Cc3ccc4c(cc(C#N)n4CCO)c3C)CC2)C1)C(C)C InChI=1S/C36H43FN8O3/c1-6-44(23(2)3)35(47)30-17-27(37)8-10-32(30)48-34-33(39-25(5)40-41-34)43-21-36(22-43)11-13-42(14-12-36)20-26-7-9-31-29(24(26)4)18-28(19-38)45(31)15-16-46/h7-10,17-18,23,46H,6,11-16,20-22H2,1-5H3 BFJVRGKSPVACHF-UHFFFAOYSA-N 793968 US20260055108, Compound 160 Menin [2-610] 87.7 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793968&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422990 528825431 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729558 CCNC(=O)N1CCC(CN2CCC3(CC2)CN(c2ncnnc2Oc2ccc(F)cc2C(=O)N(CC)C(C)C)C3)CC1 InChI=1S/C31H45FN8O3/c1-5-33-30(42)38-13-9-23(10-14-38)18-37-15-11-31(12-16-37)19-39(20-31)27-28(36-35-21-34-27)43-26-8-7-24(32)17-25(26)29(41)40(6-2)22(3)4/h7-8,17,21-23H,5-6,9-16,18-20H2,1-4H3,(H,33,42) SGUWLZNBFNJIMH-UHFFFAOYSA-N 793969 US20260055108, Compound 28 Menin [2-610] 2.20 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793969&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422991 528825432 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729559 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4[nH]c(=O)ccc4c3)CC2)C1)C(C)C InChI=1S/C32H36FN7O3/c1-4-40(21(2)3)31(42)25-16-24(33)7-9-27(25)43-30-29(34-20-35-37-30)39-18-32(19-39)11-13-38(14-12-32)17-22-5-8-26-23(15-22)6-10-28(41)36-26/h5-10,15-16,20-21H,4,11-14,17-19H2,1-3H3,(H,36,41) QURBIVLBBVQMHH-UHFFFAOYSA-N 793970 US20260055108, Compound 72 Menin [2-610] 28.0 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793970&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422992 528825433 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729560 N#Cc1ccc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C3=CCOCC3)C4)CC2)nc1 InChI=1S/C33H37FN8O2/c34-27-2-3-29(28(17-27)26-7-15-43-16-8-26)44-32-31(37-23-38-39-32)42-21-33(22-42)9-13-40(14-10-33)20-24-5-11-41(12-6-24)30-4-1-25(18-35)19-36-30/h1-4,7,17,19,23-24H,5-6,8-16,20-22H2 ZJRUAFCCHNSCHW-UHFFFAOYSA-N 793971 US20260055108, Compound 117 Menin [2-610] 175 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793971&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422993 528825434 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729561 Cc1nc(-c2cc(F)ccc2Oc2nncnc2N2CC3(CCN(Cc4ccc5c(cc(C#N)n5CCO)c4C)CC3)C2)n(C(C)C)n1 InChI=1S/C35H39FN10O2/c1-22(2)46-32(40-24(4)42-46)29-15-26(36)6-8-31(29)48-34-33(38-21-39-41-34)44-19-35(20-44)9-11-43(12-10-35)18-25-5-7-30-28(23(25)3)16-27(17-37)45(30)13-14-47/h5-8,15-16,21-22,47H,9-14,18-20H2,1-4H3 YBIUDQXIFWGEIO-UHFFFAOYSA-N 793972 US20260055108, Compound 161 Menin [2-610] 18.7 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793972&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422994 528825435 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729562 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)NC(C)C)CC3)CC2)C1)C(C)C InChI=1S/C32H47FN8O3/c1-6-41(23(4)5)30(42)26-17-25(33)7-8-27(26)44-29-28(34-21-35-37-29)40-19-32(20-40)11-15-38(16-12-32)18-24-9-13-39(14-10-24)31(43)36-22(2)3/h7-8,17,21-24H,6,9-16,18-20H2,1-5H3,(H,36,43) RIAJLPLGZBZSEF-UHFFFAOYSA-N 793973 US20260055108, Compound 29 Menin [2-610] 2.50 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793973&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422995 528825436 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729563 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3cnc4c(c3)OC[C@H](c3ccc(OC)nc3)O4)CC2)C1)C(C)C InChI=1S/C36H41FN8O5/c1-5-45(23(2)3)35(46)27-15-26(37)7-8-28(27)49-34-32(40-22-41-42-34)44-20-36(21-44)10-12-43(13-11-36)18-24-14-29-33(39-16-24)50-30(19-48-29)25-6-9-31(47-4)38-17-25/h6-9,14-17,22-23,30H,5,10-13,18-21H2,1-4H3 CFUUBSHZEGLWDR-UHFFFAOYSA-N 793974 US20260055108, Compound 73 Menin [2-610] >1000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793974&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422996 528825437 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729564 Cc1nc(-c2cc(F)ccc2Oc2nncnc2N2CC3(CCN(CC4CCN(c5ccc(C#N)cn5)CC4)CC3)C2)n(C(C)C)n1 InChI=1S/C34H40FN11O/c1-23(2)46-31(40-24(3)42-46)28-16-27(35)5-6-29(28)47-33-32(38-22-39-41-33)45-20-34(21-45)10-14-43(15-11-34)19-25-8-12-44(13-9-25)30-7-4-26(17-36)18-37-30/h4-7,16,18,22-23,25H,8-15,19-21H2,1-3H3 YHYQAZGMKJJNHO-UHFFFAOYSA-N 793975 US20260055108, Compound 118 Menin [2-610] >1000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793975&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422997 528825438 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729565 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4c(c3)cc(C#N)n4CCO)CC2)C1)C(C)C InChI=1S/C34H39FN8O3/c1-4-42(23(2)3)33(45)28-17-26(35)6-8-30(28)46-32-31(37-22-38-39-32)41-20-34(21-41)9-11-40(12-10-34)19-24-5-7-29-25(15-24)16-27(18-36)43(29)13-14-44/h5-8,15-17,22-23,44H,4,9-14,19-21H2,1-3H3 WTSDKIPMNGPKEA-UHFFFAOYSA-N 793976 US20260055108, Compound 162 Menin [2-610] 13.9 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793976&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422998 528825439 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729566 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)NC(C)(C)C)CC3)CC2)C1)C(C)C InChI=1S/C33H49FN8O3/c1-7-42(23(2)3)30(43)26-18-25(34)8-9-27(26)45-29-28(35-22-36-38-29)41-20-33(21-41)12-16-39(17-13-33)19-24-10-14-40(15-11-24)31(44)37-32(4,5)6/h8-9,18,22-24H,7,10-17,19-21H2,1-6H3,(H,37,44) NRZSGFAZHDGNNU-UHFFFAOYSA-N 793977 US20260055108, Compound 30 Menin [2-610] 1.70 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793977&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178422999 528825440 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729567 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4oc(C(=O)NC)cc4c3)CC2)C1)C(C)C InChI=1S/C33H38FN7O4/c1-5-41(21(2)3)32(43)25-16-24(34)7-9-27(25)45-31-29(36-20-37-38-31)40-18-33(19-40)10-12-39(13-11-33)17-22-6-8-26-23(14-22)15-28(44-26)30(42)35-4/h6-9,14-16,20-21H,5,10-13,17-19H2,1-4H3,(H,35,42) WHDFPLCPUYXTOO-UHFFFAOYSA-N 793978 US20260055108, Compound 74 Menin [2-610] 418 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793978&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423000 528825441 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729568 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cccc(C(N)=O)n4)CC3)CC2)C1)C(C)C InChI=1S/C34H44FN9O3/c1-4-44(23(2)3)33(46)26-18-25(35)8-9-28(26)47-32-31(37-22-38-40-32)43-20-34(21-43)12-16-41(17-13-34)19-24-10-14-42(15-11-24)29-7-5-6-27(39-29)30(36)45/h5-9,18,22-24H,4,10-17,19-21H2,1-3H3,(H2,36,45) VGWVERBVWANICK-UHFFFAOYSA-N 793979 US20260055108, Compound 119 Menin [2-610] 2.30 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793979&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423001 528825442 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729569 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC(C2(N(CCO)Cc3ccc4[nH]c(C#N)cc4c3C)CC2)C1)C(C)C InChI=1S/C34H39FN8O3/c1-5-43(21(2)3)33(45)28-14-25(35)7-9-30(28)46-32-31(37-20-38-40-32)41-18-24(19-41)34(10-11-34)42(12-13-44)17-23-6-8-29-27(22(23)4)15-26(16-36)39-29/h6-9,14-15,20-21,24,39,44H,5,10-13,17-19H2,1-4H3 NOMALIJTPOGIPB-UHFFFAOYSA-N 793980 US20260055108, Compound 163 Menin [2-610] 4.90 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793980&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423002 528825443 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729570 O=C(NC1CC1)N1CCC(CN2CCC3(CC2)CN(c2ncnnc2Oc2ccc(F)cc2)C3)CC1 InChI=1S/C26H34FN7O2/c27-20-1-5-22(6-2-20)36-24-23(28-18-29-31-24)34-16-26(17-34)9-13-32(14-10-26)15-19-7-11-33(12-8-19)25(35)30-21-3-4-21/h1-2,5-6,18-19,21H,3-4,7-17H2,(H,30,35) JJBQKVFYFMUIRU-UHFFFAOYSA-N 793981 US20260055108, Compound 31 Menin [2-610] 155 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793981&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423003 528825444 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729571 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4oc(C(=O)NC)c(C)c4c3)CC2)C1)C(C)C InChI=1S/C34H40FN7O4/c1-6-42(21(2)3)33(44)26-16-24(35)8-10-28(26)46-32-30(37-20-38-39-32)41-18-34(19-41)11-13-40(14-12-34)17-23-7-9-27-25(15-23)22(4)29(45-27)31(43)36-5/h7-10,15-16,20-21H,6,11-14,17-19H2,1-5H3,(H,36,43) FVKQGXYYELLHGP-UHFFFAOYSA-N 793982 US20260055108, Compound 75 Menin [2-610] 955 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793982&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423004 528825445 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729572 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccnc(C(C)(C)O)c4)CC3)CC2)C1)C(C)C InChI=1S/C36H49FN8O3/c1-6-45(25(2)3)34(46)29-19-27(37)7-8-30(29)48-33-32(39-24-40-41-33)44-22-36(23-44)12-17-42(18-13-36)21-26-10-15-43(16-11-26)28-9-14-38-31(20-28)35(4,5)47/h7-9,14,19-20,24-26,47H,6,10-13,15-18,21-23H2,1-5H3 PWOCMNLUAVXPSH-UHFFFAOYSA-N 793983 US20260055108, Compound 120 Menin [2-610] 15.2 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793983&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423005 528825446 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729573 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cccc(N)n4)CC3)CC2)C1)C(C)C InChI=1S/C33H44FN9O2/c1-4-43(23(2)3)32(44)26-18-25(34)8-9-27(26)45-31-30(36-22-37-39-31)42-20-33(21-42)12-16-40(17-13-33)19-24-10-14-41(15-11-24)29-7-5-6-28(35)38-29/h5-9,18,22-24H,4,10-17,19-21H2,1-3H3,(H2,35,38) VXZXPAQARYOQBG-UHFFFAOYSA-N 793984 US20260055108, Compound 164 Menin [2-610] 4.60 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793984&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001296 528825447 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729574 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)NC4CCC4)CC3)CC2)C1)C(C)C InChI=1S/C33H47FN8O3/c1-4-42(23(2)3)31(43)27-18-25(34)8-9-28(27)45-30-29(35-22-36-38-30)41-20-33(21-41)12-16-39(17-13-33)19-24-10-14-40(15-11-24)32(44)37-26-6-5-7-26/h8-9,18,22-24,26H,4-7,10-17,19-21H2,1-3H3,(H,37,44) XXCLPTIDSHJDKP-UHFFFAOYSA-N 793985 US20260055108, Compound 32 Menin [2-610] 1.000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793985&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423006 528825448 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729575 C[C@H]1CN(C)CCN1C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccccn4)CC3)CC2)C1 InChI=1S/C34H44FN9O2/c1-25-20-40(2)17-18-44(25)33(45)28-19-27(35)6-7-29(28)46-32-31(37-24-38-39-32)43-22-34(23-43)10-15-41(16-11-34)21-26-8-13-42(14-9-26)30-5-3-4-12-36-30/h3-7,12,19,24-26H,8-11,13-18,20-23H2,1-2H3 WHWTUTKBOIEOCI-UHFFFAOYSA-N 793986 US20260055108, Compound 76 Menin [2-610] 878 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793986&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423007 528825449 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729576 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cccc(C(C)(C)O)n4)CC3)CC2)C1)C(C)C InChI=1S/C36H49FN8O3/c1-6-45(25(2)3)34(46)28-20-27(37)10-11-29(28)48-33-32(38-24-39-41-33)44-22-36(23-44)14-18-42(19-15-36)21-26-12-16-43(17-13-26)31-9-7-8-30(40-31)35(4,5)47/h7-11,20,24-26,47H,6,12-19,21-23H2,1-5H3 NKHUYZHWKNLSLU-UHFFFAOYSA-N 793987 US20260055108, Compound 121 Menin [2-610] 1.50 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793987&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423008 528825450 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729577 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccncn4)CC3)CC2)C1)C(C)C InChI=1S/C32H42FN9O2/c1-4-42(23(2)3)31(43)26-17-25(33)5-6-27(26)44-30-29(36-22-37-38-30)41-19-32(20-41)10-15-39(16-11-32)18-24-8-13-40(14-9-24)28-7-12-34-21-35-28/h5-7,12,17,21-24H,4,8-11,13-16,18-20H2,1-3H3 UAYLPVZZFBGLEJ-UHFFFAOYSA-N 793988 US20260055108, Compound 165 Menin [2-610] 5.30 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793988&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897752 528825451 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729578 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)NC4COC4)CC3)CC2)C1)C(C)C InChI=1S/C32H45FN8O4/c1-4-41(22(2)3)30(42)26-15-24(33)5-6-27(26)45-29-28(34-21-35-37-29)40-19-32(20-40)9-13-38(14-10-32)16-23-7-11-39(12-8-23)31(43)36-25-17-44-18-25/h5-6,15,21-23,25H,4,7-14,16-20H2,1-3H3,(H,36,43) NYWFOJBEHXFBDI-UHFFFAOYSA-N 793989 US20260055108, Compound 33 Menin [2-610] 2.90 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793989&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423009 528825452 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729579 C[C@H]1COCCN1C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccccn4)CC3)CC2)C1 InChI=1S/C33H41FN8O3/c1-24-20-44-17-16-42(24)32(43)27-18-26(34)5-6-28(27)45-31-30(36-23-37-38-31)41-21-33(22-41)9-14-39(15-10-33)19-25-7-12-40(13-8-25)29-4-2-3-11-35-29/h2-6,11,18,23-25H,7-10,12-17,19-22H2,1H3 FOIXRRQJDKEFCE-UHFFFAOYSA-N 793990 US20260055108, Compound 77 Menin [2-610] 73.8 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793990&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423010 528825453 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729580 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCC(n4ccccc4=O)CC3)CC2)C1)C(C)C InChI=1S/C34H44FN7O3/c1-4-41(24(2)3)33(44)28-19-26(35)10-13-29(28)45-32-31(36-23-37-38-32)40-21-34(22-40)14-17-39(18-15-34)20-25-8-11-27(12-9-25)42-16-6-5-7-30(42)43/h5-7,10,13,16,19,23-25,27H,4,8-9,11-12,14-15,17-18,20-22H2,1-3H3 NRYGEINUEYVDDP-UHFFFAOYSA-N 793991 US20260055108, Compound 122 Menin [2-610] >200 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793991&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423011 528825454 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729581 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cccnn4)CC3)CC2)C1)C(C)C InChI=1S/C32H42FN9O2/c1-4-42(23(2)3)31(43)26-18-25(33)7-8-27(26)44-30-29(34-22-36-38-30)41-20-32(21-41)11-16-39(17-12-32)19-24-9-14-40(15-10-24)28-6-5-13-35-37-28/h5-8,13,18,22-24H,4,9-12,14-17,19-21H2,1-3H3 GYNOKSGTGWKGGN-UHFFFAOYSA-N 793992 US20260055108, Compound 166 Menin [2-610] 2.60 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793992&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423012 528825455 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729582 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)NCc4ccccc4)CC3)CC2)C1)C(C)C InChI=1S/C36H47FN8O3/c1-4-45(26(2)3)34(46)30-20-29(37)10-11-31(30)48-33-32(39-25-40-41-33)44-23-36(24-44)14-18-42(19-15-36)22-28-12-16-43(17-13-28)35(47)38-21-27-8-6-5-7-9-27/h5-11,20,25-26,28H,4,12-19,21-24H2,1-3H3,(H,38,47) WHNLMMDYABJFHD-UHFFFAOYSA-N 793993 US20260055108, Compound 34 Menin [2-610] 8.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793993&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423013 528825456 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729583 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ncccn4)CC3)CC2)C1)C(C)C InChI=1S/C32H42FN9O2/c1-4-42(23(2)3)30(43)26-18-25(33)6-7-27(26)44-29-28(36-22-37-38-29)41-20-32(21-41)10-16-39(17-11-32)19-24-8-14-40(15-9-24)31-34-12-5-13-35-31/h5-7,12-13,18,22-24H,4,8-11,14-17,19-21H2,1-3H3 IQSOPBILIVSEPW-UHFFFAOYSA-N 793994 US20260055108, Compound 78 Menin [2-610] 28.8 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793994&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423014 528825457 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729584 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CC=C(c4ccccn4)CC3)CC2)C1)C(C)C InChI=1S/C34H42FN7O2/c1-4-42(24(2)3)33(43)28-19-27(35)12-13-30(28)44-32-31(37-23-38-39-32)41-21-34(22-41)14-17-40(18-15-34)20-25-8-10-26(11-9-25)29-7-5-6-16-36-29/h5-7,10,12-13,16,19,23-25H,4,8-9,11,14-15,17-18,20-22H2,1-3H3 YAOUBRVVLOQIGR-UHFFFAOYSA-N 793995 US20260055108, Compound 123 Menin [2-610] 133 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793995&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423015 528825458 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729585 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccnnc4)CC3)CC2)C1)C(C)C InChI=1S/C32H42FN9O2/c1-4-42(23(2)3)31(43)27-17-25(33)5-6-28(27)44-30-29(34-22-37-38-30)41-20-32(21-41)10-15-39(16-11-32)19-24-8-13-40(14-9-24)26-7-12-35-36-18-26/h5-7,12,17-18,22-24H,4,8-11,13-16,19-21H2,1-3H3 IDGMCVAFZXNANF-UHFFFAOYSA-N 793996 US20260055108, Compound 167 Menin [2-610] 14.9 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793996&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423016 528825459 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729586 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)NCCOC)CC3)CC2)C1)C(C)C InChI=1S/C32H47FN8O4/c1-5-41(23(2)3)30(42)26-18-25(33)6-7-27(26)45-29-28(35-22-36-37-29)40-20-32(21-40)10-15-38(16-11-32)19-24-8-13-39(14-9-24)31(43)34-12-17-44-4/h6-7,18,22-24H,5,8-17,19-21H2,1-4H3,(H,34,43) ZALAYVUUVWHEAW-UHFFFAOYSA-N 793997 US20260055108, Compound 35 Menin [2-610] 10.7 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793997&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423017 528825460 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729587 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccn(C)n4)CC3)CC2)C1)C(C)C InChI=1S/C32H44FN9O2/c1-5-42(23(2)3)31(43)26-18-25(33)6-7-27(26)44-30-29(34-22-35-36-30)41-20-32(21-41)11-16-39(17-12-32)19-24-8-14-40(15-9-24)28-10-13-38(4)37-28/h6-7,10,13,18,22-24H,5,8-9,11-12,14-17,19-21H2,1-4H3 JOMYVKFCTVSEBD-UHFFFAOYSA-N 793998 US20260055108, Compound 79 Menin [2-610] 57.7 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793998&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423018 528825461 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729588 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc(-c4ccccn4)cc3)CC2)C1)C(C)C InChI=1S/C34H38FN7O2/c1-4-42(24(2)3)33(43)28-19-27(35)12-13-30(28)44-32-31(37-23-38-39-32)41-21-34(22-41)14-17-40(18-15-34)20-25-8-10-26(11-9-25)29-7-5-6-16-36-29/h5-13,16,19,23-24H,4,14-15,17-18,20-22H2,1-3H3 BMDZUGVUANISRB-UHFFFAOYSA-N 793999 US20260055108, Compound 124 Menin [2-610] >200 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793999&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423019 528825462 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729589 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cccc(=O)n4C)CC3)CC2)C1)C(C)C InChI=1S/C34H45FN8O3/c1-5-43(24(2)3)33(45)27-19-26(35)9-10-28(27)46-32-31(36-23-37-38-32)42-21-34(22-42)13-17-40(18-14-34)20-25-11-15-41(16-12-25)29-7-6-8-30(44)39(29)4/h6-10,19,23-25H,5,11-18,20-22H2,1-4H3 NKOUBCCTWOAPSI-UHFFFAOYSA-N 794000 US20260055108, Compound 168 Menin [2-610] >200 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794000&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423020 528825463 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729590 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)Nc4ccccc4F)CC3)CC2)C1)C(C)C InChI=1S/C35H44F2N8O3/c1-4-45(24(2)3)33(46)27-19-26(36)9-10-30(27)48-32-31(38-23-39-41-32)44-21-35(22-44)13-17-42(18-14-35)20-25-11-15-43(16-12-25)34(47)40-29-8-6-5-7-28(29)37/h5-10,19,23-25H,4,11-18,20-22H2,1-3H3,(H,40,47) BGGAKICRIGSPAD-UHFFFAOYSA-N 794001 US20260055108, Compound 36 Menin [2-610] 4.60 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794001&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001297 528825464 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729591 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4nc(C#N)co4)CC3)CC2)C1)C(C)C InChI=1S/C32H40FN9O3/c1-4-42(22(2)3)30(43)26-15-24(33)5-6-27(26)45-29-28(35-21-36-38-29)41-19-32(20-41)9-13-39(14-10-32)17-23-7-11-40(12-8-23)31-37-25(16-34)18-44-31/h5-6,15,18,21-23H,4,7-14,17,19-20H2,1-3H3 NRQBAGDRZRPQEX-UHFFFAOYSA-N 794002 US20260055108, Compound 80 Menin [2-610] 6.60 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794002&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423021 528825465 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729592 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCC(O)(c4ccccn4)CC3)CC2)C1)C(C)C InChI=1S/C34H44FN7O3/c1-4-42(24(2)3)32(43)27-19-26(35)8-9-28(27)45-31-30(37-23-38-39-31)41-21-33(22-41)14-17-40(18-15-33)20-25-10-12-34(44,13-11-25)29-7-5-6-16-36-29/h5-9,16,19,23-25,44H,4,10-15,17-18,20-22H2,1-3H3 NYKSEOOMOVWECC-UHFFFAOYSA-N 794003 US20260055108, Compound 125 Menin [2-610] >200 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794003&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423022 528825466 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729593 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)c4cnn5cccnc45)CC3)CC2)C1)C(C)C InChI=1S/C35H43FN10O3/c1-4-45(24(2)3)34(48)27-18-26(36)6-7-29(27)49-32-31(38-23-39-41-32)44-21-35(22-44)10-16-42(17-11-35)20-25-8-14-43(15-9-25)33(47)28-19-40-46-13-5-12-37-30(28)46/h5-7,12-13,18-19,23-25H,4,8-11,14-17,20-22H2,1-3H3 XWMXLYXXFPVPCY-UHFFFAOYSA-N 794004 US20260055108, Compound 169 Menin [2-610] 166 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794004&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897776 528825467 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729594 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)Nc4ccccn4)CC3)CC2)C1)C(C)C InChI=1S/C34H44FN9O3/c1-4-44(24(2)3)32(45)27-19-26(35)8-9-28(27)47-31-30(37-23-38-40-31)43-21-34(22-43)12-17-41(18-13-34)20-25-10-15-42(16-11-25)33(46)39-29-7-5-6-14-36-29/h5-9,14,19,23-25H,4,10-13,15-18,20-22H2,1-3H3,(H,36,39,46) GLJCSRHHQBPCIT-UHFFFAOYSA-N 794005 US20260055108, Compound 37 Menin [2-610] 13.7 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794005&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423023 528825468 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729595 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(=O)n(C)n4)CC3)CC2)C1)C(C)C InChI=1S/C33H44FN9O3/c1-5-43(23(2)3)32(45)26-18-25(34)6-7-27(26)46-31-30(35-22-36-37-31)42-20-33(21-42)12-16-40(17-13-33)19-24-10-14-41(15-11-24)28-8-9-29(44)39(4)38-28/h6-9,18,22-24H,5,10-17,19-21H2,1-4H3 QDWNIHXPRZHBJF-UHFFFAOYSA-N 794006 US20260055108, Compound 81 Menin [2-610] 54.9 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794006&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423024 528825469 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729596 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(C#N)cn4)CC3(C)C)CC2)C1)C(C)C InChI=1S/C36H46FN9O2/c1-6-46(25(2)3)34(47)29-17-28(37)8-9-30(29)48-33-32(40-24-41-42-33)45-22-36(23-45)12-15-43(16-13-36)20-27-11-14-44(21-35(27,4)5)31-10-7-26(18-38)19-39-31/h7-10,17,19,24-25,27H,6,11-16,20-23H2,1-5H3 VEMLYXMRPOGJMB-UHFFFAOYSA-N 794007 US20260055108, Compound 126 Menin [2-610] 14.6 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794007&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423025 528825470 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729597 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C(=O)OC)CC3)CC2)C1)C(C)C InChI=1S/C30H42FN7O4/c1-5-38(21(2)3)28(39)24-16-23(31)6-7-25(24)42-27-26(32-20-33-34-27)37-18-30(19-37)10-14-35(15-11-30)17-22-8-12-36(13-9-22)29(40)41-4/h6-7,16,20-22H,5,8-15,17-19H2,1-4H3 OIWQKGASQAWNQK-UHFFFAOYSA-N 794008 US20260055108, Compound 170 Menin [2-610] 34.4 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794008&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897754 528825471 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729598 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(C(F)(F)F)nn4)CC3)CC2)C1)C(C)C InChI=1S/C33H41F4N9O2/c1-4-46(22(2)3)31(47)25-17-24(34)5-6-26(25)48-30-29(38-21-39-42-30)45-19-32(20-45)11-15-43(16-12-32)18-23-9-13-44(14-10-23)28-8-7-27(40-41-28)33(35,36)37/h5-8,17,21-23H,4,9-16,18-20H2,1-3H3 OLSNXWMWIQYDPS-UHFFFAOYSA-N 794009 US20260055108, Compound 38 Menin [2-610] 1.70 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794009&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897753 528825472 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729599 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccn5nccc5n4)CC3)CC2)C1)C(C)C InChI=1S/C34H43FN10O2/c1-4-44(24(2)3)33(46)27-19-26(35)5-6-28(27)47-32-31(36-23-37-40-32)43-21-34(22-43)11-17-41(18-12-34)20-25-8-14-42(15-9-25)29-10-16-45-30(39-29)7-13-38-45/h5-7,10,13,16,19,23-25H,4,8-9,11-12,14-15,17-18,20-22H2,1-3H3 ZJOFXUGZCGQNCS-UHFFFAOYSA-N 794010 US20260055108, Compound 82 Menin [2-610] 2.60 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794010&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423026 528825473 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729600 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC(C2(NCc3ccc4[nH]c(C#N)cc4c3C)CC2)C1)C(C)C InChI=1S/C32H35FN8O2/c1-5-41(19(2)3)31(42)26-12-23(33)7-9-28(26)43-30-29(35-18-37-39-30)40-16-22(17-40)32(10-11-32)36-15-21-6-8-27-25(20(21)4)13-24(14-34)38-27/h6-9,12-13,18-19,22,36,38H,5,10-11,15-17H2,1-4H3 VUJHEWSQVTYGEG-UHFFFAOYSA-N 794011 US20260055108, Compound 127 Menin [2-610] 24.3 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794011&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897742 528825474 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729601 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(C(C)C3CCN(c4cc(OC)c(OC)nn4)CC3)CC2)C1)C(C)C InChI=1S/C35H48FN9O4/c1-7-45(23(2)3)34(46)27-18-26(36)8-9-28(27)49-33-31(37-22-38-40-33)44-20-35(21-44)12-16-42(17-13-35)24(4)25-10-14-43(15-11-25)30-19-29(47-5)32(48-6)41-39-30/h8-9,18-19,22-25H,7,10-17,20-21H2,1-6H3 ZIVIHZLXGDVTCW-UHFFFAOYSA-N 794012 US20260055108, Compound 171 Menin [2-610] 41.3 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794012&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001287 528825475 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729602 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C[C@@H](O)CC#N)CC3)CC2)C1)C(C)C InChI=1S/C32H45FN8O3/c1-4-41(23(2)3)31(43)27-17-25(33)5-6-28(27)44-30-29(35-22-36-37-30)40-20-32(21-40)10-15-39(16-11-32)18-24-8-13-38(14-9-24)19-26(42)7-12-34/h5-6,17,22-24,26,42H,4,7-11,13-16,18-21H2,1-3H3 GUGALLFARKQPDS-UHFFFAOYSA-N 794013 US20260055108, Compound 39 Menin [2-610] 68.3 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794013&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423027 528825476 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729603 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(C4=NN5CCC(=O)N=C5C=C4)CC3)CC2)C1)C(C)C InChI=1S/C35H45FN10O3/c1-4-45(24(2)3)34(48)27-19-26(36)5-6-28(27)49-33-32(37-23-38-40-33)44-21-35(22-44)12-17-42(18-13-35)20-25-9-14-43(15-10-25)30-8-7-29-39-31(47)11-16-46(29)41-30/h5-8,19,23-25H,4,9-18,20-22H2,1-3H3 PLIWAALMLMPMRN-UHFFFAOYSA-N 794014 US20260055108, Compound 83 Menin [2-610] 222 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794014&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423028 528825477 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729604 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CCC(C2(NCc3ccc4[nH]c(C#N)cc4c3C)CC2)C1)C(C)C InChI=1S/C33H37FN8O2/c1-5-42(20(2)3)32(43)27-14-24(34)7-9-29(27)44-31-30(36-19-38-40-31)41-13-10-23(18-41)33(11-12-33)37-17-22-6-8-28-26(21(22)4)15-25(16-35)39-28/h6-9,14-15,19-20,23,37,39H,5,10-13,17-18H2,1-4H3 VSFYKENFRPJJHG-UHFFFAOYSA-N 794015 US20260055108, Compound 128 Menin [2-610] 5.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794015&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423029 528825478 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729605 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(C(=O)C3CCN(c4ccccn4)CC3)CC2)C1)C(C)C InChI=1S/C33H41FN8O3/c1-4-42(23(2)3)32(44)26-19-25(34)8-9-27(26)45-30-29(36-22-37-38-30)41-20-33(21-41)12-17-40(18-13-33)31(43)24-10-15-39(16-11-24)28-7-5-6-14-35-28/h5-9,14,19,22-24H,4,10-13,15-18,20-21H2,1-3H3 REKPBSHBQRSJHX-UHFFFAOYSA-N 794016 US20260055108, Compound 172 Menin [2-610] >200 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794016&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001334 528825479 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729606 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cnccn4)CC3)CC2)C1)C(C)C InChI=1S/C32H42FN9O2/c1-4-42(23(2)3)31(43)26-17-25(33)5-6-27(26)44-30-29(36-22-37-38-30)41-20-32(21-41)9-15-39(16-10-32)19-24-7-13-40(14-8-24)28-18-34-11-12-35-28/h5-6,11-12,17-18,22-24H,4,7-10,13-16,19-21H2,1-3H3 XOAINHVICWJAJF-UHFFFAOYSA-N 794017 US20260055108, Compound 40 Menin [2-610] 11.4 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794017&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423030 528825480 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729607 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(C)nn4)CC3)CC2)C1)C(C)C InChI=1S/C33H44FN9O2/c1-5-43(23(2)3)32(44)27-18-26(34)7-8-28(27)45-31-30(35-22-36-39-31)42-20-33(21-42)12-16-40(17-13-33)19-25-10-14-41(15-11-25)29-9-6-24(4)37-38-29/h6-9,18,22-23,25H,5,10-17,19-21H2,1-4H3 TWMMQYNYEBHMHO-UHFFFAOYSA-N 794018 US20260055108, Compound 84 Menin [2-610] 0.900 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794018&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423031 528825481 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729608 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC(C2CCCN2Cc2ccc3[nH]c(C#N)cc3c2C)C1)C(C)C InChI=1S/C33H37FN8O2/c1-5-42(20(2)3)33(43)27-13-24(34)9-11-30(27)44-32-31(36-19-37-39-32)41-17-23(18-41)29-7-6-12-40(29)16-22-8-10-28-26(21(22)4)14-25(15-35)38-28/h8-11,13-14,19-20,23,29,38H,5-7,12,16-18H2,1-4H3 NGZJFQPOUFUACG-UHFFFAOYSA-N 794019 US20260055108, Compound 129 Menin [2-610] 178 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794019&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423032 528825482 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729609 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CN3CCN(c4ccccn4)CC3)CC2)C1)C(C)C InChI=1S/C32H42FN9O2/c1-4-42(24(2)3)31(43)26-19-25(33)8-9-27(26)44-30-29(35-22-36-37-30)41-20-32(21-41)10-13-38(14-11-32)23-39-15-17-40(18-16-39)28-7-5-6-12-34-28/h5-9,12,19,22,24H,4,10-11,13-18,20-21,23H2,1-3H3 JSDSRQSZISPPNF-UHFFFAOYSA-N 794020 US20260055108, Compound 173 Menin [2-610] 750 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794020&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423033 528825483 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729610 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cnc(Cl)nn4)CC3)CC2)C1)C(C)C InChI=1S/C31H40ClFN10O2/c1-4-43(21(2)3)29(44)24-15-23(33)5-6-25(24)45-28-27(35-20-36-38-28)42-18-31(19-42)9-13-40(14-10-31)17-22-7-11-41(12-8-22)26-16-34-30(32)39-37-26/h5-6,15-16,20-22H,4,7-14,17-19H2,1-3H3 XWXCVBSFWRZDII-UHFFFAOYSA-N 794021 US20260055108, Compound 41 Menin [2-610] 3.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794021&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423034 528825484 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729611 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(C)cnn4)CC3)CC2)C1)C(C)C InChI=1S/C33H44FN9O2/c1-5-43(23(2)3)32(44)27-17-26(34)6-7-28(27)45-31-30(35-22-37-39-31)42-20-33(21-42)10-14-40(15-11-33)19-25-8-12-41(13-9-25)29-16-24(4)18-36-38-29/h6-7,16-18,22-23,25H,5,8-15,19-21H2,1-4H3 HXOAQCNKLMDDCH-UHFFFAOYSA-N 794022 US20260055108, Compound 85 Menin [2-610] 4.20 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794022&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423035 528825485 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729612 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4c(cc(C#N)n4C4COC4)c3C)CC2)C1)C(C)C InChI=1S/C36H41FN8O3/c1-5-44(23(2)3)35(46)30-14-26(37)7-9-32(30)48-34-33(39-22-40-41-34)43-20-36(21-43)10-12-42(13-11-36)17-25-6-8-31-29(24(25)4)15-27(16-38)45(31)28-18-47-19-28/h6-9,14-15,22-23,28H,5,10-13,17-21H2,1-4H3 PUMWZLWXQQALNL-UHFFFAOYSA-N 794023 US20260055108, Compound 130 Menin [2-610] 2.70 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794023&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423036 528825486 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729613 CCN(C(=S)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(OC)c(OC)nn4)CC3)CC2)C1)C(C)C InChI=1S/C34H46FN9O3S/c1-6-44(23(2)3)33(48)26-17-25(35)7-8-27(26)47-32-30(36-22-37-39-32)43-20-34(21-43)11-15-41(16-12-34)19-24-9-13-42(14-10-24)29-18-28(45-4)31(46-5)40-38-29/h7-8,17-18,22-24H,6,9-16,19-21H2,1-5H3 HSZDUIYFVUHFCM-UHFFFAOYSA-N 794024 US20260055108, Compound 107 Menin [2-610] 3.30 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794024&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423037 528825487 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729614 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(Br)c(=O)n4C)CC3)CC2)C1)C(C)C InChI=1S/C34H44BrFN8O3/c1-5-44(23(2)3)32(45)26-18-25(36)6-8-28(26)47-31-30(37-22-38-39-31)43-20-34(21-43)12-16-41(17-13-34)19-24-10-14-42(15-11-24)29-9-7-27(35)33(46)40(29)4/h6-9,18,22-24H,5,10-17,19-21H2,1-4H3 QFBVLSCSUWJWMI-UHFFFAOYSA-N 794025 US20260055108, Compound 42 Menin [2-610] 89.9 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794025&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423038 528825488 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729615 Cc1ccc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3-c3ccnn3C(C)C)C4)CC2)nn1 InChI=1S/C33H41FN10O/c1-23(2)44-28(8-13-37-44)27-18-26(34)5-6-29(27)45-32-31(35-22-36-40-32)43-20-33(21-43)11-16-41(17-12-33)19-25-9-14-42(15-10-25)30-7-4-24(3)38-39-30/h4-8,13,18,22-23,25H,9-12,14-17,19-21H2,1-3H3 CULPFRCRVCLNIM-UHFFFAOYSA-N 794026 US20260055108, Compound 86 Menin [2-610] 1.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794026&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423039 528825489 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729616 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(Cc3ccc4[nH]c(C#N)c(C5=CCOCC5)c4c3C)CC2)C1)C(C)C InChI=1S/C38H43FN8O3/c1-5-47(24(2)3)37(48)29-18-28(39)7-9-32(29)50-36-35(41-23-42-44-36)46-21-38(22-46)12-14-45(15-13-38)20-27-6-8-30-33(25(27)4)34(31(19-40)43-30)26-10-16-49-17-11-26/h6-10,18,23-24,43H,5,11-17,20-22H2,1-4H3 FSWBZWALHOWNEI-UHFFFAOYSA-N 794027 US20260055108, Compound 131 Menin [2-610] 18.0 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794027&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001281 528825490 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729617 [2H]C(c1ccc2[nH]c(C#N)cc2c1)N1CCC2(CC1)CN(c1ncnnc1Oc1ccc(F)cc1C(=O)N(CC)C(C)C)C2 InChI=1S/C32H35FN8O2/c1-4-41(21(2)3)31(42)26-15-24(33)6-8-28(26)43-30-29(35-20-36-38-30)40-18-32(19-40)9-11-39(12-10-32)17-22-5-7-27-23(13-22)14-25(16-34)37-27/h5-8,13-15,20-21,37H,4,9-12,17-19H2,1-3H3/i17D PAXQKGAQGQTZOH-OKWSDYJOSA-N 794028 US20260055108, Compound 175 Menin [2-610] 1.50 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794028&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423040 528825491 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729618 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc5nccn5n4)CC3)CC2)C1)C(C)C InChI=1S/C34H43FN10O2/c1-4-44(24(2)3)33(46)27-19-26(35)5-6-28(27)47-32-31(37-23-38-39-32)43-21-34(22-43)11-16-41(17-12-34)20-25-9-14-42(15-10-25)30-8-7-29-36-13-18-45(29)40-30/h5-8,13,18-19,23-25H,4,9-12,14-17,20-22H2,1-3H3 JATTXLJPFBAVEC-UHFFFAOYSA-N 794029 US20260055108, Compound 43 Menin [2-610] 6.40 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794029&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423041 528825492 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729619 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(N)nn4)CC3)CC2)C1)C(C)C InChI=1S/C32H43FN10O2/c1-4-43(22(2)3)31(44)25-17-24(33)5-6-26(25)45-30-29(35-21-36-39-30)42-19-32(20-42)11-15-40(16-12-32)18-23-9-13-41(14-10-23)28-8-7-27(34)37-38-28/h5-8,17,21-23H,4,9-16,18-20H2,1-3H3,(H2,34,37) DASPBOQLSMGRNK-UHFFFAOYSA-N 794030 US20260055108, Compound 87 Menin [2-610] 37.2 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794030&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423042 528825493 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729620 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cccc(CO)n4)CC3)CC2)C1)C(C)C InChI=1S/C34H45FN8O3/c1-4-43(24(2)3)33(45)28-18-26(35)8-9-29(28)46-32-31(36-23-37-39-32)42-21-34(22-42)12-16-40(17-13-34)19-25-10-14-41(15-11-25)30-7-5-6-27(20-44)38-30/h5-9,18,23-25,44H,4,10-17,19-22H2,1-3H3 FPGOMTZFWPWNIM-UHFFFAOYSA-N 794031 US20260055108, Compound 132 Menin [2-610] 2.70 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794031&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897735 528825494 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729621 [2H]C(c1ccc2oc(C#N)cc2c1)N1CCC2(CC1)CN(c1ncnnc1Oc1ccc(F)cc1C(=O)N(CC)C(C)C)C2 InChI=1S/C32H34FN7O3/c1-4-40(21(2)3)31(41)26-15-24(33)6-8-28(26)43-30-29(35-20-36-37-30)39-18-32(19-39)9-11-38(12-10-32)17-22-5-7-27-23(13-22)14-25(16-34)42-27/h5-8,13-15,20-21H,4,9-12,17-19H2,1-3H3/i17D RHPQSYVYUHBXOJ-OKWSDYJOSA-N 794032 US20260055108, Compound 176 Menin [2-610] 6.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794032&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423043 528825495 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729622 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(C5CC5)nn4)CC3)CC2)C1)C(C)C InChI=1S/C35H46FN9O2/c1-4-45(24(2)3)34(46)28-19-27(36)7-9-30(28)47-33-32(37-23-38-41-33)44-21-35(22-44)13-17-42(18-14-35)20-25-11-15-43(16-12-25)31-10-8-29(39-40-31)26-5-6-26/h7-10,19,23-26H,4-6,11-18,20-22H2,1-3H3 JFOYBMJIDRHOAJ-UHFFFAOYSA-N 794033 US20260055108, Compound 44 Menin [2-610] 4.30 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794033&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423044 528825496 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729623 CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4ccc(OC)nn4)CC3)CC2)C1)C(C)C InChI=1S/C33H44FN9O3/c1-5-43(23(2)3)32(44)26-18-25(34)6-7-27(26)46-31-30(35-22-36-39-31)42-20-33(21-42)12-16-40(17-13-33)19-24-10-14-41(15-11-24)28-8-9-29(45-4)38-37-28/h6-9,18,22-24H,5,10-17,19-21H2,1-4H3 QWVQLMAUQXKFLK-UHFFFAOYSA-N 794034 US20260055108, Compound 88 Menin [2-610] 1.10 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794034&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423045 528825497 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729624 C=Cc1ccc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C(=O)N(CC)C(C)C)C4)CC2)nn1 InChI=1S/C34H44FN9O2/c1-5-27-8-10-30(39-38-27)42-15-11-25(12-16-42)20-41-17-13-34(14-18-41)21-43(22-34)31-32(40-37-23-36-31)46-29-9-7-26(35)19-28(29)33(45)44(6-2)24(3)4/h5,7-10,19,23-25H,1,6,11-18,20-22H2,2-4H3 LOULNLWVRYGMBV-UHFFFAOYSA-N 794035 US20260055108, Compound 133 Menin [2-610] 2.00 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794035&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176897748 528825498 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729625 COc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C(=O)NC(C)C)C4)CC2)nnc1OC InChI=1S/C32H42FN9O4/c1-21(2)36-29(43)24-15-23(33)5-6-25(24)46-31-28(34-20-35-38-31)42-18-32(19-42)9-13-40(14-10-32)17-22-7-11-41(12-8-22)27-16-26(44-3)30(45-4)39-37-27/h5-6,15-16,20-22H,7-14,17-19H2,1-4H3,(H,36,43) NCENZIAUOPZBIA-UHFFFAOYSA-N 794036 US20260055108, Compound 177 Menin [2-610] 47.3 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794036&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001291 528825499 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729626 CCNC(=O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(OC)c(OC)nn4)CC3)CC2)C1 InChI=1S/C31H40FN9O4/c1-4-33-28(42)23-15-22(32)5-6-24(23)45-30-27(34-20-35-37-30)41-18-31(19-41)9-13-39(14-10-31)17-21-7-11-40(12-8-21)26-16-25(43-2)29(44-3)38-36-26/h5-6,15-16,20-21H,4,7-14,17-19H2,1-3H3,(H,33,42) FDHNLLWUKHBRRI-UHFFFAOYSA-N 794037 US20260055108, Compound 178 Menin [2-610] 124 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794037&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001322 528825500 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729627 C=CC(=O)Nc1ccc(N2CC3(CCC(CN4CCC5(CC4)CN(c4ncnnc4Oc4ccc(F)cc4C(=O)N(CC)C(C)C)C5)CC3)C2)cc1 InChI=1S/C40H51FN8O3/c1-5-35(50)44-31-8-10-32(11-9-31)47-23-39(24-47)15-13-29(14-16-39)22-46-19-17-40(18-20-46)25-48(26-40)36-37(45-43-27-42-36)52-34-12-7-30(41)21-33(34)38(51)49(6-2)28(3)4/h5,7-12,21,27-29H,1,6,13-20,22-26H2,2-4H3,(H,44,50) OLVDUGWQUATRCJ-UHFFFAOYSA-N 794038 US20260055108, Compound 180 Menin [2-610] 3.90 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794038&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423046 528825501 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729628 C=CC(=O)N1CCC(c2ccc(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C(=O)N(CC)C(C)C)C4)cc2)CC1 InChI=1S/C37H46FN7O3/c1-5-33(46)43-17-13-29(14-18-43)28-9-7-27(8-10-28)22-42-19-15-37(16-20-42)23-44(24-37)34-35(41-40-25-39-34)48-32-12-11-30(38)21-31(32)36(47)45(6-2)26(3)4/h5,7-12,21,25-26,29H,1,6,13-20,22-24H2,2-4H3 NJZBILNVKKFROT-UHFFFAOYSA-N 794039 US20260055108, Compound 182 Menin [2-610] >1000 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794039&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423047 528825502 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729629 COc1cc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C(=O)O)C4)CC2)nnc1OC InChI=1S/C29H35FN8O5/c1-41-23-14-24(33-35-26(23)42-2)37-9-5-19(6-10-37)15-36-11-7-29(8-12-36)16-38(17-29)25-27(34-32-18-31-25)43-22-4-3-20(30)13-21(22)28(39)40/h3-4,13-14,18-19H,5-12,15-17H2,1-2H3,(H,39,40) STZQUSKPKDRPQC-UHFFFAOYSA-N 794040 US20260055108, Compound 184 Menin [2-610] >100.0 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794040&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001314 528825503 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729630 CC/N=C(O)c1cc(F)ccc1Oc1nncnc1N1CC2(CCN(CC3CCN(c4cc(OC)c(OC)nn4)CC3)CC2)C1 InChI=1S/C31H40FN9O4/c1-4-33-28(42)23-15-22(32)5-6-24(23)45-30-27(34-20-35-37-30)41-18-31(19-41)9-13-39(14-10-31)17-21-7-11-40(12-8-21)26-16-25(43-2)29(44-3)38-36-26/h5-6,15-16,20-21H,4,7-14,17-19H2,1-3H3,(H,33,42) FDHNLLWUKHBRRI-UHFFFAOYSA-N 794041 US20260055108, Compound 179 Menin [2-610] 560 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794041&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 176001322 528825504 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729631 C=CC(=O)Nc1cccc(N2CC3(CCC(CN4CCC5(CC4)CN(c4ncnnc4Oc4ccc(F)cc4C(=O)N(CC)C(C)C)C5)CC3)C2)c1 InChI=1S/C40H51FN8O3/c1-5-35(50)44-31-8-7-9-32(21-31)47-23-39(24-47)14-12-29(13-15-39)22-46-18-16-40(17-19-46)25-48(26-40)36-37(45-43-27-42-36)52-34-11-10-30(41)20-33(34)38(51)49(6-2)28(3)4/h5,7-11,20-21,27-29H,1,6,12-19,22-26H2,2-4H3,(H,44,50) AFBOGTVTBBQJCU-UHFFFAOYSA-N 794042 US20260055108, Compound 181 Menin [2-610] 25.5 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794042&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423048 528825505 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2 729632 C=CC(=O)Nc1cccc(N2CCC(CN3CCC4(CC3)CN(c3ncnnc3Oc3ccc(F)cc3C(=O)N(CC)C(C)C)C4)CC2)c1 InChI=1S/C37H47FN8O3/c1-5-33(47)41-29-8-7-9-30(21-29)44-16-12-27(13-17-44)22-43-18-14-37(15-19-43)23-45(24-37)34-35(42-40-25-39-34)49-32-11-10-28(38)20-31(32)36(48)46(6-2)26(3)4/h5,7-11,20-21,25-27H,1,6,12-19,22-24H2,2-4H3,(H,41,47) OQCAEXLWBKAAHO-UHFFFAOYSA-N 794043 US20260055108, Compound 183 Menin [2-610] 4.00 US Patent 10.7270/Q2FX7GGP aid1798066 US20260055108 ZHANG, W; YANG, H; CAI, H; SU, W 2/26/2026 7/9/2026 Hutchmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2134&target=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794043&enzyme=Menin+%5B2-610%5D&column=ki&startPg=0&Increment=50&submit=Search 178423049 528825506 1 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL 8GPN,8E90,9WNJ,9WNA,9WKX,9WKV,4OG5,4OG4,4OG3,8VA6,6O5I,6BY8,4OG8,4OG7,4OG6,8VA5 Menin MEN1_HUMAN O00255 A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2