BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 731274 CC(C)C[C@@H]1CN2CCc3cc(c(cc3[C@H]2CC1=O)OC)OC InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3 MKJIEFSOBYUXJB-UHFFFAOYSA-N 50048891 (3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one::CHEMBL61636::US12565495, Example TBZ Synaptic vesicular amine transporter Rattus norvegicus 23.0 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048891&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search YHL 8JTA,8T69,9D7W 667453 103979272 CHEMBL61636 C11168 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731275 COc1cc2CCN3C[C@@H](CC(C)C)[C@H](O)C[C@@H]3c2cc1OC |r| InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3 WEQLWGNDNRARGE-UHFFFAOYSA-N 50301021 (+)-dihydrotetrabenzaine::CHEMBL576222::US11053242, Compound R,R,R-DHTBZ::US12565495, Example DHTBZ Synaptic vesicular amine transporter Rattus norvegicus 10.9 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301021&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 14580381 104155382 CHEMBL576222 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731276 COCCCOc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2 InChI=1S/C22H33NO4/c1-15(2)10-17-14-23-7-6-16-11-22(27-9-5-8-25-3)21(26-4)12-18(16)19(23)13-20(17)24/h11-12,15,17,19H,5-10,13-14H2,1-4H3 KQRCGDYVJYZXIW-UHFFFAOYSA-N 794176 US12565495, Example 1 Synaptic vesicular amine transporter Rattus norvegicus 45.0 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794176 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794176&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083391 528825639 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731277 COc1cc2c(cc1OCCCCF)CCN1CC(CC(C)C)C(=O)CC21 InChI=1S/C22H32FNO3/c1-15(2)10-17-14-24-8-6-16-11-22(27-9-5-4-7-23)21(26-3)12-18(16)19(24)13-20(17)25/h11-12,15,17,19H,4-10,13-14H2,1-3H3 LUJUHPBVTWEMQO-UHFFFAOYSA-N 794177 US12565495, Example 2 Synaptic vesicular amine transporter Rattus norvegicus 6.27 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794177&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085540 528825640 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731278 COc1cc2c(cc1OCC1CC1)CCN1CC(CC(C)C)C(=O)CC21 InChI=1S/C22H31NO3/c1-14(2)8-17-12-23-7-6-16-9-22(26-13-15-4-5-15)21(25-3)10-18(16)19(23)11-20(17)24/h9-10,14-15,17,19H,4-8,11-13H2,1-3H3 AROHCULXUAYCFG-UHFFFAOYSA-N 794178 US12565495, Example 3 Synaptic vesicular amine transporter Rattus norvegicus 3.37 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794178 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794178&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083337 528825641 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731279 CCCOc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2 InChI=1S/C21H31NO3/c1-5-8-25-21-10-15-6-7-22-13-16(9-14(2)3)19(23)12-18(22)17(15)11-20(21)24-4/h10-11,14,16,18H,5-9,12-13H2,1-4H3 DKVDUNYTORXFGJ-UHFFFAOYSA-N 794179 US12565495, Example 4 Synaptic vesicular amine transporter Rattus norvegicus 0.980 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794179&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085543 528825642 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731280 COc1cc2c(cc1OCC(F)F)CCN1CC(CC(C)C)C(=O)CC21 InChI=1S/C20H27F2NO3/c1-12(2)6-14-10-23-5-4-13-7-19(26-11-20(21)22)18(25-3)8-15(13)16(23)9-17(14)24/h7-8,12,14,16,20H,4-6,9-11H2,1-3H3 BUTFAWWBSXHVOR-UHFFFAOYSA-N 794180 US12565495, Example 5 Synaptic vesicular amine transporter Rattus norvegicus 10.6 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794180&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085545 528825643 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731281 COc1cc2c(cc1OCC(F)(F)F)CCN1CC(CC(C)C)C(=O)CC21 InChI=1S/C20H26F3NO3/c1-12(2)6-14-10-24-5-4-13-7-19(27-11-20(21,22)23)18(26-3)8-15(13)16(24)9-17(14)25/h7-8,12,14,16H,4-6,9-11H2,1-3H3 KDRPZRCRXQEKQP-UHFFFAOYSA-N 794181 US12565495, Example 6 Synaptic vesicular amine transporter Rattus norvegicus 5.13 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794181&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083392 528825644 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731282 COc1cc2c(cc1OCCCC(F)(F)F)CCN1CC(CC(C)C)C(=O)CC21 InChI=1S/C22H30F3NO3/c1-14(2)9-16-13-26-7-5-15-10-21(29-8-4-6-22(23,24)25)20(28-3)11-17(15)18(26)12-19(16)27/h10-11,14,16,18H,4-9,12-13H2,1-3H3 UHEPXRKSLPPTMI-UHFFFAOYSA-N 794182 US12565495, Example 7 Synaptic vesicular amine transporter Rattus norvegicus 5.40 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794182&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083401 528825645 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731283 COc1cc2c(cc1OCCF)CCN1CC(CC(C)C)C(=O)CC21 InChI=1S/C20H28FNO3/c1-13(2)8-15-12-22-6-4-14-9-20(25-7-5-21)19(24-3)10-16(14)17(22)11-18(15)23/h9-10,13,15,17H,4-8,11-12H2,1-3H3 GMKXHQLDWQPZOY-UHFFFAOYSA-N 794183 US12565495, Example 8 Synaptic vesicular amine transporter Rattus norvegicus 23.0 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794183&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085538 528825646 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731284 COc1cc2c(cc1OCC(C)C)CCN1CC(CC(C)C)C(=O)CC21 InChI=1S/C22H33NO3/c1-14(2)8-17-12-23-7-6-16-9-22(26-13-15(3)4)21(25-5)10-18(16)19(23)11-20(17)24/h9-10,14-15,17,19H,6-8,11-13H2,1-5H3 GGQRXUPVSORZFU-UHFFFAOYSA-N 794184 US12565495, Example 9 Synaptic vesicular amine transporter Rattus norvegicus 6.03 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794184&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085541 528825647 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731285 CCOc1cc2CCN3CC(CC(C)C)C(O)CC3c2cc1OC InChI=1S/C20H31NO3/c1-5-24-20-9-14-6-7-21-12-15(8-13(2)3)18(22)11-17(21)16(14)10-19(20)23-4/h9-10,13,15,17-18,22H,5-8,11-12H2,1-4H3 GMIKCMWFQLESAU-UHFFFAOYSA-N 50573716 CHEMBL4874168::US12565495, Example 16 Synaptic vesicular amine transporter Rattus norvegicus 12.9 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573716 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573716&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083376 471063861 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731286 COCCCOc1cc2CCN3CC(CC(C)C)C(O)CC3c2cc1OC InChI=1S/C22H35NO4/c1-15(2)10-17-14-23-7-6-16-11-22(27-9-5-8-25-3)21(26-4)12-18(16)19(23)13-20(17)24/h11-12,15,17,19-20,24H,5-10,13-14H2,1-4H3 UZMMDWDRHARBKK-UHFFFAOYSA-N 50573714 CHEMBL4867332::US12565495, Example 17 Synaptic vesicular amine transporter Rattus norvegicus 58.0 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573714 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573714&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083365 471063859 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731287 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC1CC1 InChI=1S/C22H33NO3/c1-14(2)8-17-12-23-7-6-16-9-22(26-13-15-4-5-15)21(25-3)10-18(16)19(23)11-20(17)24/h9-10,14-15,17,19-20,24H,4-8,11-13H2,1-3H3 HSVRNWDLNHQKIR-UHFFFAOYSA-N 50573713 CHEMBL4859304::US12565495, Example 19 Synaptic vesicular amine transporter Rattus norvegicus 5.99 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573713 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573713&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083364 471063858 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731288 CCCOc1cc2CCN3CC(CC(C)C)C(O)CC3c2cc1OC InChI=1S/C21H33NO3/c1-5-8-25-21-10-15-6-7-22-13-16(9-14(2)3)19(23)12-18(22)17(15)11-20(21)24-4/h10-11,14,16,18-19,23H,5-9,12-13H2,1-4H3 APTNWMDUNNLOBC-UHFFFAOYSA-N 50573715 CHEMBL4874676::US12565495, Example 20 Synaptic vesicular amine transporter Rattus norvegicus 4.90 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573715 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573715&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083362 471063860 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731289 CC(C)CC1CN2CCc3cc(OCC4CC4)c(OCC4CC4)cc3C2CC1=O InChI=1S/C25H35NO3/c1-16(2)9-20-13-26-8-7-19-10-24(28-14-17-3-4-17)25(29-15-18-5-6-18)11-21(19)22(26)12-23(20)27/h10-11,16-18,20,22H,3-9,12-15H2,1-2H3 YVPNXBXRNWTSRC-UHFFFAOYSA-N 794189 US12565495, Comparative Example 35 Synaptic vesicular amine transporter Rattus norvegicus 190 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794189&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 166010235 528825652 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731290 CC(C)CC1CN2CCc3cc(OCCCF)c(OCCCF)cc3C2CC1=O InChI=1S/C23H33F2NO3/c1-16(2)11-18-15-26-8-5-17-12-22(28-9-3-6-24)23(29-10-4-7-25)13-19(17)20(26)14-21(18)27/h12-13,16,18,20H,3-11,14-15H2,1-2H3 WDRRUNAQZZAUCV-UHFFFAOYSA-N 794190 US12565495, Comparative Example 36 Synaptic vesicular amine transporter Rattus norvegicus >500 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794190&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 166010217 528825653 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731291 CCCOc1cc2c(cc1OCCCF)CCN1CC(CC(C)C)C(=O)CC21 InChI=1S/C23H34FNO3/c1-4-9-27-23-13-19-17(12-22(23)28-10-5-7-24)6-8-25-15-18(11-16(2)3)21(26)14-20(19)25/h12-13,16,18,20H,4-11,14-15H2,1-3H3 UVZNBOAEOFDOTB-UHFFFAOYSA-N 794191 US12565495, Comparative Example 37 Synaptic vesicular amine transporter Rattus norvegicus >500 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794191&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 166010218 528825654 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731292 COc1cc2c(cc1O)C1CC(=O)C(CC(C)C)CN1CC2 InChI=1S/C18H25NO3/c1-11(2)6-13-10-19-5-4-12-7-18(22-3)17(21)8-14(12)15(19)9-16(13)20/h7-8,11,13,15,21H,4-6,9-10H2,1-3H3 BYXXYAARZQFEGE-UHFFFAOYSA-N 794192 US12565495, Comparative Example 38 Synaptic vesicular amine transporter Rattus norvegicus >500 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794192&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 59272807 528825655 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731293 COc1cc2c(cc1OCCCF)C1CC(=O)C(CC(C)C)CN1CC2 InChI=1S/C21H30FNO3/c1-14(2)9-16-13-23-7-5-15-10-20(25-3)21(26-8-4-6-22)11-17(15)18(23)12-19(16)24/h10-11,14,16,18H,4-9,12-13H2,1-3H3 KUYIKHNNGNRFSZ-UHFFFAOYSA-N 794193 US12565495, Comparative Example 39 Synaptic vesicular amine transporter Rattus norvegicus >500 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794193&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 166010225 528825656 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731294 COc1cc2c(cc1OCC1CC1)C1CC(=O)C(CC(C)C)CN1CC2 InChI=1S/C22H31NO3/c1-14(2)8-17-12-23-7-6-16-9-21(25-3)22(26-13-15-4-5-15)10-18(16)19(23)11-20(17)24/h9-10,14-15,17,19H,4-8,11-13H2,1-3H3 SJHMDALOQWFTPG-UHFFFAOYSA-N 794194 US12565495, Comparative Example 40 Synaptic vesicular amine transporter Rattus norvegicus >500 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794194&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 166010222 528825657 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731295 CCOc1cc2c(cc1O)C1CC(=O)C(CC(C)C)CN1CC2 InChI=1S/C19H27NO3/c1-4-23-19-8-13-5-6-20-11-14(7-12(2)3)17(21)10-16(20)15(13)9-18(19)22/h8-9,12,14,16,22H,4-7,10-11H2,1-3H3 WUWGYOGIKGJUNC-UHFFFAOYSA-N 794195 US12565495, Comparative Example 41 Synaptic vesicular amine transporter Rattus norvegicus 280 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794195&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083381 528825658 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731296 CC(C)CC1CN2CCc3cc(OCCCF)c(OCCCF)cc3C2CC1O InChI=1S/C23H35F2NO3/c1-16(2)11-18-15-26-8-5-17-12-22(28-9-3-6-24)23(29-10-4-7-25)13-19(17)20(26)14-21(18)27/h12-13,16,18,20-21,27H,3-11,14-15H2,1-2H3 CJXIXVWDJPIYQY-UHFFFAOYSA-N 794196 US12565495, Comparative Example 42 Synaptic vesicular amine transporter Rattus norvegicus >500 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794196&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 166010211 528825659 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731297 CCOc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OC InChI=1S/C20H31NO3/c1-5-24-20-10-16-14(9-19(20)23-4)6-7-21-12-15(8-13(2)3)18(22)11-17(16)21/h9-10,13,15,17-18,22H,5-8,11-12H2,1-4H3 OOULYVRDYMQLSB-UHFFFAOYSA-N 50573722 CHEMBL4849938::US12565495, Comparative Example 43 Synaptic vesicular amine transporter Rattus norvegicus >500 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573722 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573722&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085609 471063867 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731298 COc1cc2CCN3C[C@@H](CC(C)C)[C@H](O)C[C@@H]3c2cc1OC |r| InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3 WEQLWGNDNRARGE-UHFFFAOYSA-N 50301021 (+)-dihydrotetrabenzaine::CHEMBL576222::US11053242, Compound R,R,R-DHTBZ::US12565495, Example DHTBZ Synaptic vesicular amine transporter Rattus norvegicus 7.23 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301021&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 14580381 104155382 CHEMBL576222 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731299 COc1cc2CCN3C[C@@H](CC(C)C)[C@H](O)C[C@@H]3c2cc1OC |r| InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3 WEQLWGNDNRARGE-UHFFFAOYSA-N 50301021 (+)-dihydrotetrabenzaine::CHEMBL576222::US11053242, Compound R,R,R-DHTBZ::US12565495, Example DHTBZ Synaptic vesicular amine transporter Rattus norvegicus 4.22 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301021&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 14580381 104155382 CHEMBL576222 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731300 COc1ccc2c(c1)[C@H]1C[C@@H](OC(=O)[C@@H](N)C(C)C)[C@H](CC(C)C)CN1CC2 InChI=1S/C23H36N2O3/c1-14(2)10-17-13-25-9-8-16-6-7-18(27-5)11-19(16)20(25)12-21(17)28-23(26)22(24)15(3)4/h6-7,11,14-15,17,20-22H,8-10,12-13,24H2,1-5H3 SHSLYYYRIOEDFZ-UHFFFAOYSA-N 794198 US12565495, Example VBZ Synaptic vesicular amine transporter Rattus norvegicus >500 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794198 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794198&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 178423142 528825661 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731301 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC(F)(F)F InChI=1S/C20H28F3NO3/c1-12(2)6-14-10-24-5-4-13-7-19(27-11-20(21,22)23)18(26-3)8-15(13)16(24)9-17(14)25/h7-8,12,14,16-17,25H,4-6,9-11H2,1-3H3 JXFGMMABBUBPCW-UHFFFAOYSA-N 50573717 CHEMBL4854730::US12565495, Example 28 Synaptic vesicular amine transporter Rattus norvegicus 5.45 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573717&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085542 471063862 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731302 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC(F)(F)F InChI=1S/C20H28F3NO3/c1-12(2)6-14-10-24-5-4-13-7-19(27-11-20(21,22)23)18(26-3)8-15(13)16(24)9-17(14)25/h7-8,12,14,16-17,25H,4-6,9-11H2,1-3H3 JXFGMMABBUBPCW-UHFFFAOYSA-N 50573717 CHEMBL4854730::US12565495, Example 28 Synaptic vesicular amine transporter Rattus norvegicus 3.18 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573717&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085542 471063862 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731303 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC(F)(F)F InChI=1S/C20H28F3NO3/c1-12(2)6-14-10-24-5-4-13-7-19(27-11-20(21,22)23)18(26-3)8-15(13)16(24)9-17(14)25/h7-8,12,14,16-17,25H,4-6,9-11H2,1-3H3 JXFGMMABBUBPCW-UHFFFAOYSA-N 50573717 CHEMBL4854730::US12565495, Example 28 Synaptic vesicular amine transporter Rattus norvegicus 470 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573717&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085542 471063862 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731304 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC(F)(F)F InChI=1S/C20H28F3NO3/c1-12(2)6-14-10-24-5-4-13-7-19(27-11-20(21,22)23)18(26-3)8-15(13)16(24)9-17(14)25/h7-8,12,14,16-17,25H,4-6,9-11H2,1-3H3 JXFGMMABBUBPCW-UHFFFAOYSA-N 50573717 CHEMBL4854730::US12565495, Example 28 Synaptic vesicular amine transporter Rattus norvegicus 270 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573717&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085542 471063862 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731305 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC(F)(F)F InChI=1S/C20H28F3NO3/c1-12(2)6-14-10-24-5-4-13-7-19(27-11-20(21,22)23)18(26-3)8-15(13)16(24)9-17(14)25/h7-8,12,14,16-17,25H,4-6,9-11H2,1-3H3 JXFGMMABBUBPCW-UHFFFAOYSA-N 50573717 CHEMBL4854730::US12565495, Example 28 Synaptic vesicular amine transporter Rattus norvegicus 2.54 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573717&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085542 471063862 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731306 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC(F)(F)F InChI=1S/C20H28F3NO3/c1-12(2)6-14-10-24-5-4-13-7-19(27-11-20(21,22)23)18(26-3)8-15(13)16(24)9-17(14)25/h7-8,12,14,16-17,25H,4-6,9-11H2,1-3H3 JXFGMMABBUBPCW-UHFFFAOYSA-N 50573717 CHEMBL4854730::US12565495, Example 28 Synaptic vesicular amine transporter Rattus norvegicus 1.48 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573717&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085542 471063862 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731307 COc1cc2c(cc1OCC(F)(F)F)CCN1CC(CC(C)C)C(OC(=O)[C@@H](N)C(C)C)CC21 InChI=1S/C25H37F3N2O4/c1-14(2)8-17-12-30-7-6-16-9-22(33-13-25(26,27)28)21(32-5)10-18(16)19(30)11-20(17)34-24(31)23(29)15(3)4/h9-10,14-15,17,19-20,23H,6-8,11-13,29H2,1-5H3 ITZFOMNWHNKMLR-UHFFFAOYSA-N 794202 US12565495, Example 21-P3 Synaptic vesicular amine transporter Rattus norvegicus 180 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794202 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794202&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085581 528825665 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731308 COc1cc2c(cc1OCC(F)(F)F)CCN1CC(CC(C)C)C(OC(=O)[C@@H](N)C(C)C)CC21 InChI=1S/C25H37F3N2O4/c1-14(2)8-17-12-30-7-6-16-9-22(33-13-25(26,27)28)21(32-5)10-18(16)19(30)11-20(17)34-24(31)23(29)15(3)4/h9-10,14-15,17,19-20,23H,6-8,11-13,29H2,1-5H3 ITZFOMNWHNKMLR-UHFFFAOYSA-N 794202 US12565495, Example 21-P3 Synaptic vesicular amine transporter Rattus norvegicus 110 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794202 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794202&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085581 528825665 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731309 COc1cc2c(cc1OC)[C@H]1CC(O)C(CC(C)C)CN1CC2 InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3 WEQLWGNDNRARGE-UHFFFAOYSA-N 794203 US12565495, Example DHTBZ-X Synaptic vesicular amine transporter Rattus norvegicus 21.0 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794203 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794203&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 137705593 528825666 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731310 COc1cc2c(cc1OC)[C@H]1CC(O)C(CC(C)C)CN1CC2 InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3 WEQLWGNDNRARGE-UHFFFAOYSA-N 794203 US12565495, Example DHTBZ-X Synaptic vesicular amine transporter Rattus norvegicus 12.3 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794203 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794203&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 137705593 528825666 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731311 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC(F)(F)F InChI=1S/C20H28F3NO3/c1-12(2)6-14-10-24-5-4-13-7-19(27-11-20(21,22)23)18(26-3)8-15(13)16(24)9-17(14)25/h7-8,12,14,16-17,25H,4-6,9-11H2,1-3H3 JXFGMMABBUBPCW-UHFFFAOYSA-N 50573717 CHEMBL4854730::US12565495, Example 28 Synaptic vesicular amine transporter Rattus norvegicus 6.13 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573717&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085542 471063862 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731312 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC(F)(F)F InChI=1S/C20H28F3NO3/c1-12(2)6-14-10-24-5-4-13-7-19(27-11-20(21,22)23)18(26-3)8-15(13)16(24)9-17(14)25/h7-8,12,14,16-17,25H,4-6,9-11H2,1-3H3 JXFGMMABBUBPCW-UHFFFAOYSA-N 50573717 CHEMBL4854730::US12565495, Example 28 Synaptic vesicular amine transporter Rattus norvegicus 3.57 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573717&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085542 471063862 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731313 COc1cc2c(cc1OCC(F)F)CCN1CC(CC(C)C)C(O)CC21 InChI=1S/C20H29F2NO3/c1-12(2)6-14-10-23-5-4-13-7-19(26-11-20(21)22)18(25-3)8-15(13)16(23)9-17(14)24/h7-8,12,14,16-17,20,24H,4-6,9-11H2,1-3H3 BIZNAUQIVJQTLG-UHFFFAOYSA-N 794204 US12565495, Example 12 Synaptic vesicular amine transporter Rattus norvegicus 3.78 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794204 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794204&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083375 528825667 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731314 COc1cc2c(cc1OCC(F)F)CCN1CC(CC(C)C)C(O)CC21 InChI=1S/C20H29F2NO3/c1-12(2)6-14-10-23-5-4-13-7-19(26-11-20(21)22)18(25-3)8-15(13)16(23)9-17(14)24/h7-8,12,14,16-17,20,24H,4-6,9-11H2,1-3H3 BIZNAUQIVJQTLG-UHFFFAOYSA-N 794204 US12565495, Example 12 Synaptic vesicular amine transporter Rattus norvegicus 2.21 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794204 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794204&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083375 528825667 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731315 COc1cc2c(cc1OCCF)CCN1CC(CC(C)C)C(O)CC21 InChI=1S/C20H30FNO3/c1-13(2)8-15-12-22-6-4-14-9-20(25-7-5-21)19(24-3)10-16(14)17(22)11-18(15)23/h9-10,13,15,17-18,23H,4-8,11-12H2,1-3H3 VOWPNVUVSQRLHO-UHFFFAOYSA-N 794205 US12565495, Example 14 Synaptic vesicular amine transporter Rattus norvegicus 10.00 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794205 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794205&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 59668644 528825668 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731316 COc1cc2c(cc1OCCF)CCN1CC(CC(C)C)C(O)CC21 InChI=1S/C20H30FNO3/c1-13(2)8-15-12-22-6-4-14-9-20(25-7-5-21)19(24-3)10-16(14)17(22)11-18(15)23/h9-10,13,15,17-18,23H,4-8,11-12H2,1-3H3 VOWPNVUVSQRLHO-UHFFFAOYSA-N 794205 US12565495, Example 14 Synaptic vesicular amine transporter Rattus norvegicus 5.83 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794205 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794205&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 59668644 528825668 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731317 COc1cc2c(cc1OCCCCF)CCN1CC(CC(C)C)C(O)CC21 InChI=1S/C22H34FNO3/c1-15(2)10-17-14-24-8-6-16-11-22(27-9-5-4-7-23)21(26-3)12-18(16)19(24)13-20(17)25/h11-12,15,17,19-20,25H,4-10,13-14H2,1-3H3 PKGRLKAXPBWLBT-UHFFFAOYSA-N 794207 US12565495, Example 18 Synaptic vesicular amine transporter Rattus norvegicus 3.55 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794207 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794207&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083366 528825670 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731318 COc1cc2c(cc1OCCCCF)CCN1CC(CC(C)C)C(O)CC21 InChI=1S/C22H34FNO3/c1-15(2)10-17-14-24-8-6-16-11-22(27-9-5-4-7-23)21(26-3)12-18(16)19(24)13-20(17)25/h11-12,15,17,19-20,25H,4-10,13-14H2,1-3H3 PKGRLKAXPBWLBT-UHFFFAOYSA-N 794207 US12565495, Example 18 Synaptic vesicular amine transporter Rattus norvegicus 2.07 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794207 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794207&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083366 528825670 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731319 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC1CC1 InChI=1S/C22H33NO3/c1-14(2)8-17-12-23-7-6-16-9-22(26-13-15-4-5-15)21(25-3)10-18(16)19(23)11-20(17)24/h9-10,14-15,17,19-20,24H,4-8,11-13H2,1-3H3 HSVRNWDLNHQKIR-UHFFFAOYSA-N 50573713 CHEMBL4859304::US12565495, Example 19 Synaptic vesicular amine transporter Rattus norvegicus 2.30 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573713 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573713&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083364 471063858 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731320 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC1CC1 InChI=1S/C22H33NO3/c1-14(2)8-17-12-23-7-6-16-9-22(26-13-15-4-5-15)21(25-3)10-18(16)19(23)11-20(17)24/h9-10,14-15,17,19-20,24H,4-8,11-13H2,1-3H3 HSVRNWDLNHQKIR-UHFFFAOYSA-N 50573713 CHEMBL4859304::US12565495, Example 19 Synaptic vesicular amine transporter Rattus norvegicus 1.34 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573713 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573713&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156083364 471063858 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731321 COc1cc2c(cc1OCCCCCF)CCN1CC(CC(C)C)C(O)CC21 InChI=1S/C23H36FNO3/c1-16(2)11-18-15-25-9-7-17-12-23(28-10-6-4-5-8-24)22(27-3)13-19(17)20(25)14-21(18)26/h12-13,16,18,20-21,26H,4-11,14-15H2,1-3H3 WHYLDGIKRLKONO-UHFFFAOYSA-N 794208 US12565495, Example 27 Synaptic vesicular amine transporter Rattus norvegicus 2.06 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794208 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794208&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 166010221 528825671 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731322 COc1cc2c(cc1OCCCCCF)CCN1CC(CC(C)C)C(O)CC21 InChI=1S/C23H36FNO3/c1-16(2)11-18-15-25-9-7-17-12-23(28-10-6-4-5-8-24)22(27-3)13-19(17)20(25)14-21(18)26/h12-13,16,18,20-21,26H,4-11,14-15H2,1-3H3 WHYLDGIKRLKONO-UHFFFAOYSA-N 794208 US12565495, Example 27 Synaptic vesicular amine transporter Rattus norvegicus 1.20 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794208 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794208&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 166010221 528825671 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731323 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC(F)(F)F InChI=1S/C20H28F3NO3/c1-12(2)6-14-10-24-5-4-13-7-19(27-11-20(21,22)23)18(26-3)8-15(13)16(24)9-17(14)25/h7-8,12,14,16-17,25H,4-6,9-11H2,1-3H3 JXFGMMABBUBPCW-UHFFFAOYSA-N 50573717 CHEMBL4854730::US12565495, Example 28 Synaptic vesicular amine transporter Rattus norvegicus 7.70 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573717&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085542 471063862 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731324 COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC(F)(F)F InChI=1S/C20H28F3NO3/c1-12(2)6-14-10-24-5-4-13-7-19(27-11-20(21,22)23)18(26-3)8-15(13)16(24)9-17(14)25/h7-8,12,14,16-17,25H,4-6,9-11H2,1-3H3 JXFGMMABBUBPCW-UHFFFAOYSA-N 50573717 CHEMBL4854730::US12565495, Example 28 Synaptic vesicular amine transporter Rattus norvegicus 4.49 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573717&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 156085542 471063862 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731325 COc1cc3c(cc1OCC2CC2)CCN4C[C@@H](CC(C)C)[C@H](O)C[C@H]34 InChI=1S/C22H33NO3/c1-14(2)8-17-12-23-7-6-16-9-22(26-13-15-4-5-15)21(25-3)10-18(16)19(23)11-20(17)24/h9-10,14-15,17,19-20,24H,4-8,11-13H2,1-3H3 HSVRNWDLNHQKIR-UHFFFAOYSA-N 794211 US12565495, Example 32 Synaptic vesicular amine transporter Rattus norvegicus 1.29 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794211 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794211&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 166010227 528825674 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1 731326 COc1cc3c(cc1OCC2CC2)CCN4C[C@@H](CC(C)C)[C@H](O)C[C@H]34 InChI=1S/C22H33NO3/c1-14(2)8-17-12-23-7-6-16-9-22(26-13-15-4-5-15)21(25-3)10-18(16)19(23)11-20(17)24/h9-10,14-15,17,19-20,24H,4-8,11-13H2,1-3H3 HSVRNWDLNHQKIR-UHFFFAOYSA-N 794211 US12565495, Example 32 Synaptic vesicular amine transporter Rattus norvegicus 0.750 US Patent 10.7270/Q2DZ0F8Z aid1798094 US12565495 Tian, J; Zhang, R; Ye, L; Yu, D; Du, G; Liu, Z; Zou, F; Cui, B 3/3/2026 7/13/2026 Luye Innomind Pharma Shijiazhuang Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794211 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8986&target=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794211&enzyme=Synaptic+vesicular+amine+transporter&column=ki&startPg=0&Increment=50&submit=Search 166010227 528825674 1 MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD Synaptic vesicular amine transporter VMAT2_RAT Q01827 Q9QVP1