BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 736184 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 US11643416, Compound 1::4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US20240150369, Compound 1::US20250270226, Compound 1::US12565502, Compound 1 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 0.160 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 736185 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 US11643416, Compound 1::4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US20240150369, Compound 1::US20250270226, Compound 1::US12565502, Compound 1 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 0.340 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 736186 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 US11643416, Compound 1::4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US20240150369, Compound 1::US20250270226, Compound 1::US12565502, Compound 1 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 3.10 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 736187 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 US11643416, Compound 1::4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US20240150369, Compound 1::US20250270226, Compound 1::US12565502, Compound 1 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 7.50 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 736188 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 US11643416, Compound 1::4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US20240150369, Compound 1::US20250270226, Compound 1::US12565502, Compound 1 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.40 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 736189 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 US11643416, Compound 2::4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 2::US20250270226, Compound 2::US12565502, Compound 2 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 0.400 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 736190 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 US11643416, Compound 2::4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 2::US20250270226, Compound 2::US12565502, Compound 2 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 0.500 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 736191 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 US11643416, Compound 2::4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 2::US20250270226, Compound 2::US12565502, Compound 2 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 41.0 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 736192 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 US11643416, Compound 2::4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 2::US20250270226, Compound 2::US12565502, Compound 2 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 98.0 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 736193 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 US11643416, Compound 2::4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 2::US20250270226, Compound 2::US12565502, Compound 2 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 4.50 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 736194 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 US11643416, Compound 3::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 3::US20250270226, Compound 3::US12565502, Compound 3 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 2.50 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 736195 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 US11643416, Compound 3::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 3::US20250270226, Compound 3::US12565502, Compound 3 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 0.560 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 736196 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 US11643416, Compound 3::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 3::US20250270226, Compound 3::US12565502, Compound 3 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 130 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 736197 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 US11643416, Compound 3::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 3::US20250270226, Compound 3::US12565502, Compound 3 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 350 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 736198 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 US11643416, Compound 3::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 3::US20250270226, Compound 3::US12565502, Compound 3 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 62.0 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 736199 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 |c:16| InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 US11643416, Compound 4::4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 4::US20250270226, Compound 4::US12565502, Compound 4 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 1.000 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 736200 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 |c:16| InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 US11643416, Compound 4::4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 4::US20250270226, Compound 4::US12565502, Compound 4 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 1.000 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 736201 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 |c:16| InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 US11643416, Compound 4::4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 4::US20250270226, Compound 4::US12565502, Compound 4 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 53.0 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 736202 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 |c:16| InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 US11643416, Compound 4::4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 4::US20250270226, Compound 4::US12565502, Compound 4 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 170 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 736203 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 |c:16| InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 US11643416, Compound 4::4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 4::US20250270226, Compound 4::US12565502, Compound 4 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 736204 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 US11643416, Compound 12::4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 12::US20250270226, Compound 12::US12565502, Compound 12 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 9.20 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 736205 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 US11643416, Compound 12::4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 12::US20250270226, Compound 12::US12565502, Compound 12 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 13.0 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 736206 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 US11643416, Compound 12::4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 12::US20250270226, Compound 12::US12565502, Compound 12 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 28.0 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 736207 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 US11643416, Compound 12::4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 12::US20250270226, Compound 12::US12565502, Compound 12 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 160 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 736208 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 US11643416, Compound 12::4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 12::US20250270226, Compound 12::US12565502, Compound 12 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 180 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 736209 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601938 US11643416, Compound 18::(R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 18::US20250270226, Compound 18::US12565502, Compound 18 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 1.70 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 736210 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601938 US11643416, Compound 18::(R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 18::US20250270226, Compound 18::US12565502, Compound 18 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 2.70 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 736211 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601938 US11643416, Compound 18::(R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 18::US20250270226, Compound 18::US12565502, Compound 18 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 33.0 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 736212 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601938 US11643416, Compound 18::(R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 18::US20250270226, Compound 18::US12565502, Compound 18 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 150 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 736213 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601938 US11643416, Compound 18::(R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 18::US20250270226, Compound 18::US12565502, Compound 18 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 736214 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |r| InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26) ZJKDYTFNXUBLEQ-UHFFFAOYSA-N 601939 US11643416, Compound 19::(S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 19::US20250270226, Compound 19::US12565502, Compound 19 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 4.30 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 736215 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |r| InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26) ZJKDYTFNXUBLEQ-UHFFFAOYSA-N 601939 US11643416, Compound 19::(S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 19::US20250270226, Compound 19::US12565502, Compound 19 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 4.80 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 736216 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |r| InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26) ZJKDYTFNXUBLEQ-UHFFFAOYSA-N 601939 US11643416, Compound 19::(S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 19::US20250270226, Compound 19::US12565502, Compound 19 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 40.0 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 736217 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |r| InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26) ZJKDYTFNXUBLEQ-UHFFFAOYSA-N 601939 US11643416, Compound 19::(S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 19::US20250270226, Compound 19::US12565502, Compound 19 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 210 US Patent 10.7270/Q21N863B aid1798173 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740804 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |r| InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26) ZJKDYTFNXUBLEQ-UHFFFAOYSA-N 601939 US11643416, Compound 19::(S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 19::US20250270226, Compound 19::US12565502, Compound 19 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740805 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |c:2| InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 US11643416, Compound 5::4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 5::US20250270226, Compound 5::US12565502, Compound 5 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 2.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740806 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |c:2| InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 US11643416, Compound 5::4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 5::US20250270226, Compound 5::US12565502, Compound 5 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 3.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740807 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |c:2| InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 US11643416, Compound 5::4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 5::US20250270226, Compound 5::US12565502, Compound 5 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 41.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740808 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |c:2| InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 US11643416, Compound 5::4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 5::US20250270226, Compound 5::US12565502, Compound 5 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 231 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740809 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |c:2| InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 US11643416, Compound 5::4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 5::US20250270226, Compound 5::US12565502, Compound 5 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 26.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740810 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601941 US11643416, Compound 23::(S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 23::US20250270226, Compound 23::US12565502, Compound 23 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 1.000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740811 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601941 US11643416, Compound 23::(S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 23::US20250270226, Compound 23::US12565502, Compound 23 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 1.000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740812 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601941 US11643416, Compound 23::(S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 23::US20250270226, Compound 23::US12565502, Compound 23 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 19.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740813 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601941 US11643416, Compound 23::(S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 23::US20250270226, Compound 23::US12565502, Compound 23 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 45.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740814 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601941 US11643416, Compound 23::(S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 23::US20250270226, Compound 23::US12565502, Compound 23 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 11.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740815 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 US11643416, Compound 42::4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 42::US20250270226, Compound 42::US12565502, Compound 42 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 1.000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740816 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 US11643416, Compound 42::4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 42::US20250270226, Compound 42::US12565502, Compound 42 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 1.000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740817 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 US11643416, Compound 42::4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 42::US20250270226, Compound 42::US12565502, Compound 42 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 57.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740818 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 US11643416, Compound 42::4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 42::US20250270226, Compound 42::US12565502, Compound 42 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 147 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740819 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 US11643416, Compound 42::4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 42::US20250270226, Compound 42::US12565502, Compound 42 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 6.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740820 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 US11643416, Compound 43::4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 43::US20250270226, Compound 43::US12565502, Compound 43 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 4.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740821 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 US11643416, Compound 43::4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 43::US20250270226, Compound 43::US12565502, Compound 43 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 4.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740822 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 US11643416, Compound 43::4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 43::US20250270226, Compound 43::US12565502, Compound 43 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 69.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740823 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 US11643416, Compound 43::4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 43::US20250270226, Compound 43::US12565502, Compound 43 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 186 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740824 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 US11643416, Compound 43::4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 43::US20250270226, Compound 43::US12565502, Compound 43 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 21.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740825 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 |t:1| InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 US11643416, Compound 45::4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 45::US20250270226, Compound 45::US12565502, Compound 45 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 16.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740826 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 |t:1| InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 US11643416, Compound 45::4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 45::US20250270226, Compound 45::US12565502, Compound 45 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 19.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740827 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 |t:1| InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 US11643416, Compound 45::4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 45::US20250270226, Compound 45::US12565502, Compound 45 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 436 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740828 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 |t:1| InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 US11643416, Compound 45::4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 45::US20250270226, Compound 45::US12565502, Compound 45 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740829 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 |t:1| InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 US11643416, Compound 45::4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 45::US20250270226, Compound 45::US12565502, Compound 45 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 240 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740830 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |t:2| InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 US11643416, Compound 46::4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 46::US20250270226, Compound 46::US12565502, Compound 46 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 2.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740831 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |t:2| InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 US11643416, Compound 46::4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 46::US20250270226, Compound 46::US12565502, Compound 46 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 2.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740832 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |t:2| InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 US11643416, Compound 46::4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 46::US20250270226, Compound 46::US12565502, Compound 46 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 22.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740833 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |t:2| InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 US11643416, Compound 46::4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 46::US20250270226, Compound 46::US12565502, Compound 46 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 83.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740834 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |t:2| InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 US11643416, Compound 46::4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 46::US20250270226, Compound 46::US12565502, Compound 46 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740835 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 US11643416, Compound 49::7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 49::US20250270226, Compound 49::US12565502, Compound 49 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 45.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740836 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 US11643416, Compound 49::7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 49::US20250270226, Compound 49::US12565502, Compound 49 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 10.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740837 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 US11643416, Compound 49::7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 49::US20250270226, Compound 49::US12565502, Compound 49 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 253 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740838 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 US11643416, Compound 49::7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 49::US20250270226, Compound 49::US12565502, Compound 49 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 480 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740839 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 US11643416, Compound 49::7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 49::US20250270226, Compound 49::US12565502, Compound 49 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 199 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740840 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 US11643416, Compound 50::6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 50::US20250270226, Compound 50::US12565502, Compound 50 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 2.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740841 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 US11643416, Compound 50::6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 50::US20250270226, Compound 50::US12565502, Compound 50 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 4.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740842 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 US11643416, Compound 50::6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 50::US20250270226, Compound 50::US12565502, Compound 50 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 113 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740843 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 US11643416, Compound 50::6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 50::US20250270226, Compound 50::US12565502, Compound 50 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 51.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740844 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 US11643416, Compound 50::6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 50::US20250270226, Compound 50::US12565502, Compound 50 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 2.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740845 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 US11643416, Compound 51::2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 51::US20250270226, Compound 51::US12565502, Compound 51 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 4.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740846 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 US11643416, Compound 51::2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 51::US20250270226, Compound 51::US12565502, Compound 51 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 5.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740847 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 US11643416, Compound 51::2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 51::US20250270226, Compound 51::US12565502, Compound 51 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 41.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740848 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 US11643416, Compound 51::2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 51::US20250270226, Compound 51::US12565502, Compound 51 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 63.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740849 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 US11643416, Compound 51::2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 51::US20250270226, Compound 51::US12565502, Compound 51 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740850 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 US11643416, Compound 52::7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 52::US20250270226, Compound 52::US12565502, Compound 52 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 18.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740851 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 US11643416, Compound 52::7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 52::US20250270226, Compound 52::US12565502, Compound 52 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 4.50 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740852 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 US11643416, Compound 52::7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 52::US20250270226, Compound 52::US12565502, Compound 52 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 27.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740853 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 US11643416, Compound 52::7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 52::US20250270226, Compound 52::US12565502, Compound 52 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 75.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740854 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 US11643416, Compound 52::7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 52::US20250270226, Compound 52::US12565502, Compound 52 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 318 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740855 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 US11643416, Compound 53::6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 53::US20250270226, Compound 53::US12565502, Compound 53 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 2.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740856 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 US11643416, Compound 53::6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 53::US20250270226, Compound 53::US12565502, Compound 53 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 4.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740857 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 US11643416, Compound 53::6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 53::US20250270226, Compound 53::US12565502, Compound 53 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 2.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740858 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 US11643416, Compound 53::6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 53::US20250270226, Compound 53::US12565502, Compound 53 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 5.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740859 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 US11643416, Compound 53::6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 53::US20250270226, Compound 53::US12565502, Compound 53 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 10.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740860 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 US11643416, Compound 54::2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 54::US20250270226, Compound 54::US12565502, Compound 54 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 2.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740861 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 US11643416, Compound 54::2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 54::US20250270226, Compound 54::US12565502, Compound 54 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 1.000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740862 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 US11643416, Compound 54::2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 54::US20250270226, Compound 54::US12565502, Compound 54 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 3.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740863 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 US11643416, Compound 54::2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 54::US20250270226, Compound 54::US12565502, Compound 54 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 7.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740864 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 US11643416, Compound 54::2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 54::US20250270226, Compound 54::US12565502, Compound 54 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 7.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740865 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 US11643416, Compound 55::2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US20240150369, Compound 55::US20250270226, Compound 55::US12565502, Compound 55 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 0.600 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740866 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 US11643416, Compound 55::2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US20240150369, Compound 55::US20250270226, Compound 55::US12565502, Compound 55 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 1.000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740867 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 US11643416, Compound 55::2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US20240150369, Compound 55::US20250270226, Compound 55::US12565502, Compound 55 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 0.300 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740868 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 US11643416, Compound 55::2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US20240150369, Compound 55::US20250270226, Compound 55::US12565502, Compound 55 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 0.400 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740869 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 US11643416, Compound 55::2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US20240150369, Compound 55::US20250270226, Compound 55::US12565502, Compound 55 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 1.000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740870 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 US11643416, Compound 59::8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 59::US20250270226, Compound 59::US12565502, Compound 59 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 5.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740871 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 US11643416, Compound 59::8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 59::US20250270226, Compound 59::US12565502, Compound 59 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 3.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740872 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 US11643416, Compound 59::8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 59::US20250270226, Compound 59::US12565502, Compound 59 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 137 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740873 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 US11643416, Compound 59::8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 59::US20250270226, Compound 59::US12565502, Compound 59 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 123 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740874 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 US11643416, Compound 59::8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 59::US20250270226, Compound 59::US12565502, Compound 59 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 5.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740875 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 US11643416, Compound 61::7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 61::US20250270226, Compound 61::US12565502, Compound 61 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 17.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740876 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 US11643416, Compound 61::7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 61::US20250270226, Compound 61::US12565502, Compound 61 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 4.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740877 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 US11643416, Compound 61::7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 61::US20250270226, Compound 61::US12565502, Compound 61 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 17.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740878 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 US11643416, Compound 61::7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 61::US20250270226, Compound 61::US12565502, Compound 61 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 40.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740879 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 US11643416, Compound 61::7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 61::US20250270226, Compound 61::US12565502, Compound 61 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 190 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740880 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 US11643416, Compound 62::N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 62::US20250270226, Compound 62::US12565502, Compound 62 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 61.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740881 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 US11643416, Compound 62::N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 62::US20250270226, Compound 62::US12565502, Compound 62 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 14.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740882 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 US11643416, Compound 62::N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 62::US20250270226, Compound 62::US12565502, Compound 62 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 82.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740883 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 US11643416, Compound 62::N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 62::US20250270226, Compound 62::US12565502, Compound 62 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 216 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740884 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 US11643416, Compound 62::N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 62::US20250270226, Compound 62::US12565502, Compound 62 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 398 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740885 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 US11643416, Compound 63::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 63::US20250270226, Compound 63::US12565502, Compound 63 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 81.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740886 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 US11643416, Compound 63::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 63::US20250270226, Compound 63::US12565502, Compound 63 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 33.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740887 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 US11643416, Compound 63::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 63::US20250270226, Compound 63::US12565502, Compound 63 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 253 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740888 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 US11643416, Compound 63::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 63::US20250270226, Compound 63::US12565502, Compound 63 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 578 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740889 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 US11643416, Compound 63::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 63::US20250270226, Compound 63::US12565502, Compound 63 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 118 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740890 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 US11643416, Compound 64::N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 64::US20250270226, Compound 64::US12565502, Compound 64 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 85.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740891 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 US11643416, Compound 64::N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 64::US20250270226, Compound 64::US12565502, Compound 64 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 23.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740892 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 US11643416, Compound 64::N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 64::US20250270226, Compound 64::US12565502, Compound 64 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 132 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740893 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 US11643416, Compound 64::N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 64::US20250270226, Compound 64::US12565502, Compound 64 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 417 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740894 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 US11643416, Compound 64::N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 64::US20250270226, Compound 64::US12565502, Compound 64 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740895 CNC(=O)Nc1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H24N8O2/c1-22-20(31)25-15-7-5-14(6-8-15)24-19-23-12-13-11-16-27-28-18(30)21(9-3-2-4-10-21)29(16)17(13)26-19/h5-8,11-12,27H,2-4,9-10H2,1H3,(H,28,30)(H2,22,25,31)(H,23,24,26) CVRCXPPQBIKZFQ-UHFFFAOYSA-N 601959 US11643416, Compound 68::1-methyl-3-(4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)phenyl)urea::US20240150369, Compound 68::US20250270226, Compound 68::US12565502, Compound 68 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 841 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601959&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360296 482093041 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740896 CNC(=O)Nc1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H24N8O2/c1-22-20(31)25-15-7-5-14(6-8-15)24-19-23-12-13-11-16-27-28-18(30)21(9-3-2-4-10-21)29(16)17(13)26-19/h5-8,11-12,27H,2-4,9-10H2,1H3,(H,28,30)(H2,22,25,31)(H,23,24,26) CVRCXPPQBIKZFQ-UHFFFAOYSA-N 601959 US11643416, Compound 68::1-methyl-3-(4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)phenyl)urea::US20240150369, Compound 68::US20250270226, Compound 68::US12565502, Compound 68 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 349 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601959&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360296 482093041 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740897 CNC(=O)Nc1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H24N8O2/c1-22-20(31)25-15-7-5-14(6-8-15)24-19-23-12-13-11-16-27-28-18(30)21(9-3-2-4-10-21)29(16)17(13)26-19/h5-8,11-12,27H,2-4,9-10H2,1H3,(H,28,30)(H2,22,25,31)(H,23,24,26) CVRCXPPQBIKZFQ-UHFFFAOYSA-N 601959 US11643416, Compound 68::1-methyl-3-(4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)phenyl)urea::US20240150369, Compound 68::US20250270226, Compound 68::US12565502, Compound 68 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 595 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601959&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360296 482093041 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740898 CNC(=O)Nc1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H24N8O2/c1-22-20(31)25-15-7-5-14(6-8-15)24-19-23-12-13-11-16-27-28-18(30)21(9-3-2-4-10-21)29(16)17(13)26-19/h5-8,11-12,27H,2-4,9-10H2,1H3,(H,28,30)(H2,22,25,31)(H,23,24,26) CVRCXPPQBIKZFQ-UHFFFAOYSA-N 601959 US11643416, Compound 68::1-methyl-3-(4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)phenyl)urea::US20240150369, Compound 68::US20250270226, Compound 68::US12565502, Compound 68 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601959&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360296 482093041 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740899 CNC(=O)Nc1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H24N8O2/c1-22-20(31)25-15-7-5-14(6-8-15)24-19-23-12-13-11-16-27-28-18(30)21(9-3-2-4-10-21)29(16)17(13)26-19/h5-8,11-12,27H,2-4,9-10H2,1H3,(H,28,30)(H2,22,25,31)(H,23,24,26) CVRCXPPQBIKZFQ-UHFFFAOYSA-N 601959 US11643416, Compound 68::1-methyl-3-(4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)phenyl)urea::US20240150369, Compound 68::US20250270226, Compound 68::US12565502, Compound 68 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 284 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601959&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360296 482093041 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740900 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)C(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C27H33N7O2/c1-18-24(35)30-22-16-20-17-28-26(31-23(20)34(22)27(18)10-4-3-5-11-27)29-21-8-6-19(7-9-21)25(36)33-14-12-32(2)13-15-33/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,30,35)(H,28,29,31) QWDLZMUWYCLKFF-UHFFFAOYSA-N 601960 US11643416, Compound 71::8'-methyl-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 71::US20250270226, Compound 71::US12565502, Compound 71 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 4.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601960&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360113 482093042 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740901 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)C(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C27H33N7O2/c1-18-24(35)30-22-16-20-17-28-26(31-23(20)34(22)27(18)10-4-3-5-11-27)29-21-8-6-19(7-9-21)25(36)33-14-12-32(2)13-15-33/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,30,35)(H,28,29,31) QWDLZMUWYCLKFF-UHFFFAOYSA-N 601960 US11643416, Compound 71::8'-methyl-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 71::US20250270226, Compound 71::US12565502, Compound 71 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 3.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601960&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360113 482093042 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740902 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)C(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C27H33N7O2/c1-18-24(35)30-22-16-20-17-28-26(31-23(20)34(22)27(18)10-4-3-5-11-27)29-21-8-6-19(7-9-21)25(36)33-14-12-32(2)13-15-33/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,30,35)(H,28,29,31) QWDLZMUWYCLKFF-UHFFFAOYSA-N 601960 US11643416, Compound 71::8'-methyl-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 71::US20250270226, Compound 71::US12565502, Compound 71 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 9.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601960&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360113 482093042 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740903 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)C(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C27H33N7O2/c1-18-24(35)30-22-16-20-17-28-26(31-23(20)34(22)27(18)10-4-3-5-11-27)29-21-8-6-19(7-9-21)25(36)33-14-12-32(2)13-15-33/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,30,35)(H,28,29,31) QWDLZMUWYCLKFF-UHFFFAOYSA-N 601960 US11643416, Compound 71::8'-methyl-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 71::US20250270226, Compound 71::US12565502, Compound 71 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 15.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601960&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360113 482093042 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740904 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)C(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C27H33N7O2/c1-18-24(35)30-22-16-20-17-28-26(31-23(20)34(22)27(18)10-4-3-5-11-27)29-21-8-6-19(7-9-21)25(36)33-14-12-32(2)13-15-33/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,30,35)(H,28,29,31) QWDLZMUWYCLKFF-UHFFFAOYSA-N 601960 US11643416, Compound 71::8'-methyl-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 71::US20250270226, Compound 71::US12565502, Compound 71 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 9.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601960&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360113 482093042 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740905 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 US11643416, Compound 74::7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 74::US20250270226, Compound 74::US12565502, Compound 74 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 29.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740906 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 US11643416, Compound 74::7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 74::US20250270226, Compound 74::US12565502, Compound 74 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 8.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740907 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 US11643416, Compound 74::7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 74::US20250270226, Compound 74::US12565502, Compound 74 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 60.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740908 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 US11643416, Compound 74::7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 74::US20250270226, Compound 74::US12565502, Compound 74 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 137 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740909 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 US11643416, Compound 74::7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 74::US20250270226, Compound 74::US12565502, Compound 74 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 653 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740910 CS(=N)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H23N7O2S/c1-30(21,29)15-7-5-14(6-8-15)23-19-22-12-13-11-16-25-26-18(28)20(9-3-2-4-10-20)27(16)17(13)24-19/h5-8,11-12,21,25H,2-4,9-10H2,1H3,(H,26,28)(H,22,23,24) WHDHBZVTAJDTDO-UHFFFAOYSA-N 601962 US11643416, Compound 79::7'-((4-(S- methylsulfonimidoyl)phenyl)amino)- 1',2'-dihydro-3'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 79::US20250270226, Compound 79::US12565502, Compound 79 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 16.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601962&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360343 482093044 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740911 CS(=N)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H23N7O2S/c1-30(21,29)15-7-5-14(6-8-15)23-19-22-12-13-11-16-25-26-18(28)20(9-3-2-4-10-20)27(16)17(13)24-19/h5-8,11-12,21,25H,2-4,9-10H2,1H3,(H,26,28)(H,22,23,24) WHDHBZVTAJDTDO-UHFFFAOYSA-N 601962 US11643416, Compound 79::7'-((4-(S- methylsulfonimidoyl)phenyl)amino)- 1',2'-dihydro-3'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 79::US20250270226, Compound 79::US12565502, Compound 79 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 5.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601962&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360343 482093044 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740912 CS(=N)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H23N7O2S/c1-30(21,29)15-7-5-14(6-8-15)23-19-22-12-13-11-16-25-26-18(28)20(9-3-2-4-10-20)27(16)17(13)24-19/h5-8,11-12,21,25H,2-4,9-10H2,1H3,(H,26,28)(H,22,23,24) WHDHBZVTAJDTDO-UHFFFAOYSA-N 601962 US11643416, Compound 79::7'-((4-(S- methylsulfonimidoyl)phenyl)amino)- 1',2'-dihydro-3'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 79::US20250270226, Compound 79::US12565502, Compound 79 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 172 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601962&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360343 482093044 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740913 CS(=N)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H23N7O2S/c1-30(21,29)15-7-5-14(6-8-15)23-19-22-12-13-11-16-25-26-18(28)20(9-3-2-4-10-20)27(16)17(13)24-19/h5-8,11-12,21,25H,2-4,9-10H2,1H3,(H,26,28)(H,22,23,24) WHDHBZVTAJDTDO-UHFFFAOYSA-N 601962 US11643416, Compound 79::7'-((4-(S- methylsulfonimidoyl)phenyl)amino)- 1',2'-dihydro-3'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 79::US20250270226, Compound 79::US12565502, Compound 79 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 291 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601962&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360343 482093044 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740914 CS(=N)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H23N7O2S/c1-30(21,29)15-7-5-14(6-8-15)23-19-22-12-13-11-16-25-26-18(28)20(9-3-2-4-10-20)27(16)17(13)24-19/h5-8,11-12,21,25H,2-4,9-10H2,1H3,(H,26,28)(H,22,23,24) WHDHBZVTAJDTDO-UHFFFAOYSA-N 601962 US11643416, Compound 79::7'-((4-(S- methylsulfonimidoyl)phenyl)amino)- 1',2'-dihydro-3'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 79::US20250270226, Compound 79::US12565502, Compound 79 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 89.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601962&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360343 482093044 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740915 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3NNC(=O)C4(CCCCC4)n3c2n1 InChI=1S/C19H21N7O3S/c20-13-4-6-14(7-5-13)30(28,29)25-18-21-11-12-10-15-23-24-17(27)19(8-2-1-3-9-19)26(15)16(12)22-18/h4-7,10-11,23H,1-3,8-9,20H2,(H,24,27)(H,21,22,25) QGIFQLWCNWTFNA-UHFFFAOYSA-N 601963 US11643416, Compound 84::4-amino-N-(3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)benzenesulfonamide::US20240150369, Compound 84::US20250270226, Compound 84::US12565502, Compound 84 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 571 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601963&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360418 482093045 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740916 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3NNC(=O)C4(CCCCC4)n3c2n1 InChI=1S/C19H21N7O3S/c20-13-4-6-14(7-5-13)30(28,29)25-18-21-11-12-10-15-23-24-17(27)19(8-2-1-3-9-19)26(15)16(12)22-18/h4-7,10-11,23H,1-3,8-9,20H2,(H,24,27)(H,21,22,25) QGIFQLWCNWTFNA-UHFFFAOYSA-N 601963 US11643416, Compound 84::4-amino-N-(3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)benzenesulfonamide::US20240150369, Compound 84::US20250270226, Compound 84::US12565502, Compound 84 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 207 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601963&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360418 482093045 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740917 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3NNC(=O)C4(CCCCC4)n3c2n1 InChI=1S/C19H21N7O3S/c20-13-4-6-14(7-5-13)30(28,29)25-18-21-11-12-10-15-23-24-17(27)19(8-2-1-3-9-19)26(15)16(12)22-18/h4-7,10-11,23H,1-3,8-9,20H2,(H,24,27)(H,21,22,25) QGIFQLWCNWTFNA-UHFFFAOYSA-N 601963 US11643416, Compound 84::4-amino-N-(3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)benzenesulfonamide::US20240150369, Compound 84::US20250270226, Compound 84::US12565502, Compound 84 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601963&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360418 482093045 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740918 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3NNC(=O)C4(CCCCC4)n3c2n1 InChI=1S/C19H21N7O3S/c20-13-4-6-14(7-5-13)30(28,29)25-18-21-11-12-10-15-23-24-17(27)19(8-2-1-3-9-19)26(15)16(12)22-18/h4-7,10-11,23H,1-3,8-9,20H2,(H,24,27)(H,21,22,25) QGIFQLWCNWTFNA-UHFFFAOYSA-N 601963 US11643416, Compound 84::4-amino-N-(3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)benzenesulfonamide::US20240150369, Compound 84::US20250270226, Compound 84::US12565502, Compound 84 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601963&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360418 482093045 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740919 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3NNC(=O)C4(CCCCC4)n3c2n1 InChI=1S/C19H21N7O3S/c20-13-4-6-14(7-5-13)30(28,29)25-18-21-11-12-10-15-23-24-17(27)19(8-2-1-3-9-19)26(15)16(12)22-18/h4-7,10-11,23H,1-3,8-9,20H2,(H,24,27)(H,21,22,25) QGIFQLWCNWTFNA-UHFFFAOYSA-N 601963 US11643416, Compound 84::4-amino-N-(3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)benzenesulfonamide::US20240150369, Compound 84::US20250270226, Compound 84::US12565502, Compound 84 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601963&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360418 482093045 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740920 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3C(=O)NCC4(CCCCC4)n3c2n1 InChI=1S/C20H22N6O3S/c21-14-4-6-15(7-5-14)30(28,29)25-19-22-11-13-10-16-18(27)23-12-20(8-2-1-3-9-20)26(16)17(13)24-19/h4-7,10-11H,1-3,8-9,12,21H2,(H,23,27)(H,22,24,25) YJGKHEQGTLAYHU-UHFFFAOYSA-N 601964 US11643416, Compound 91::4-amino-N-(6'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)benzenesulfonamide::US20240150369, Compound 91::US20250270226, Compound 91::US12565502, Compound 91 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 322 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601964&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 162360287 482093046 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 740921 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3C(=O)NCC4(CCCCC4)n3c2n1 InChI=1S/C20H22N6O3S/c21-14-4-6-15(7-5-14)30(28,29)25-19-22-11-13-10-16-18(27)23-12-20(8-2-1-3-9-20)26(16)17(13)24-19/h4-7,10-11H,1-3,8-9,12,21H2,(H,23,27)(H,22,24,25) YJGKHEQGTLAYHU-UHFFFAOYSA-N 601964 US11643416, Compound 91::4-amino-N-(6'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)benzenesulfonamide::US20240150369, Compound 91::US20250270226, Compound 91::US12565502, Compound 91 Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 Homo sapiens 287 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=81&target=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601964&enzyme=Cyclin-dependent+kinase+2%2FG1%2FS-specific+cyclin-E1&column=ki&startPg=0&Increment=50&submit=Search 162360287 482093046 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 740922 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3C(=O)NCC4(CCCCC4)n3c2n1 InChI=1S/C20H22N6O3S/c21-14-4-6-15(7-5-14)30(28,29)25-19-22-11-13-10-16-18(27)23-12-20(8-2-1-3-9-20)26(16)17(13)24-19/h4-7,10-11H,1-3,8-9,12,21H2,(H,23,27)(H,22,24,25) YJGKHEQGTLAYHU-UHFFFAOYSA-N 601964 US11643416, Compound 91::4-amino-N-(6'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)benzenesulfonamide::US20240150369, Compound 91::US20250270226, Compound 91::US12565502, Compound 91 Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 Mus musculus 361 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=101&target=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601964&enzyme=Cyclin-dependent+kinase+4%2FG1%2FS-specific+cyclin-D1&column=ki&startPg=0&Increment=50&submit=Search 162360287 482093046 2 mehqllccevetirraypdtnllndrvlramlkteetcapsvsyfkcvqkeivpsmrkivatwmlevceeqkceeevfplamnyldrflsleplkksrlqllgatcmfvaskmketipltaeklciytdnsirpeellqmelllvnklkwnlaamtphdfiehflskmpeadenkqtirkhaqtfvalcatdvkfisnppsmvaagsvvaamqglnlgspnnflscyrtthflsrvikcdpdclracqeqieallesslrqaqqnvdpkateeegeveeeaglactptdvrdvdi 9CSK,2W9Z G1/S-specific cyclin-D1 CCND1_MOUSE P25322 maatryepvaeigvgaygtvykardphsghfvalksvrvpnggaaggglpvstvrevallrrleafehpnvvrlmdvcatsrtdrdikvtlvfehidqdlrtyldkapppglpvetikdlmrqflsgldflhancivhrdlkpenilvtsngtvkladfglariysyqmaltpvvvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprevslprgafaprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkeesdae Cyclin-dependent kinase 4 CDK4_MOUSE P30285 740923 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3C(=O)NCC4(CCCCC4)n3c2n1 InChI=1S/C20H22N6O3S/c21-14-4-6-15(7-5-14)30(28,29)25-19-22-11-13-10-16-18(27)23-12-20(8-2-1-3-9-20)26(16)17(13)24-19/h4-7,10-11H,1-3,8-9,12,21H2,(H,23,27)(H,22,24,25) YJGKHEQGTLAYHU-UHFFFAOYSA-N 601964 US11643416, Compound 91::4-amino-N-(6'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)benzenesulfonamide::US20240150369, Compound 91::US20250270226, Compound 91::US12565502, Compound 91 Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 Homo sapiens 920 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=311&target=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601964&enzyme=Cyclin-dependent+kinase+6%2FG1%2FS-specific+cyclin-D3&column=ki&startPg=0&Increment=50&submit=Search 162360287 482093046 2 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 7SJ3 G1/S-specific cyclin-D3 CCND3_HUMAN P30281 B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 740924 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3C(=O)NCC4(CCCCC4)n3c2n1 InChI=1S/C20H22N6O3S/c21-14-4-6-15(7-5-14)30(28,29)25-19-22-11-13-10-16-18(27)23-12-20(8-2-1-3-9-20)26(16)17(13)24-19/h4-7,10-11H,1-3,8-9,12,21H2,(H,23,27)(H,22,24,25) YJGKHEQGTLAYHU-UHFFFAOYSA-N 601964 US11643416, Compound 91::4-amino-N-(6'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)benzenesulfonamide::US20240150369, Compound 91::US20250270226, Compound 91::US12565502, Compound 91 Cyclin-T1/Cyclin-dependent kinase 9 Homo sapiens 183 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=113&target=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601964&enzyme=Cyclin-T1%2FCyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 162360287 482093046 2 MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK 4OR5,3MIA,3MI9,6CYT,5L1Z,4OGR,4IMY Cyclin-T1 CCNT1_HUMAN O60563 A9XU13 E7EX76 O60581 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 740925 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 US11643416, Compound 1::4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US20240150369, Compound 1::US20250270226, Compound 1::US12565502, Compound 1 Cyclin-dependent kinase 1 Homo sapiens 2.20 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740926 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 US11643416, Compound 1::4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US20240150369, Compound 1::US20250270226, Compound 1::US12565502, Compound 1 CDK3/Cyclin E Homo sapiens 0.940 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740927 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 US11643416, Compound 1::4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US20240150369, Compound 1::US20250270226, Compound 1::US12565502, Compound 1 Cyclin-dependent kinase 5 Homo sapiens 0.680 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740928 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 US11643416, Compound 1::4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US20240150369, Compound 1::US20250270226, Compound 1::US12565502, Compound 1 Cyclin-dependent kinase 5 activator 1 (CDK5-P25) Homo sapiens 0.800 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=951&target=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 1 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 1UNL,1UNH,1UNG,7VDS,7VDR,7VDQ,7VDP,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 740929 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 US11643416, Compound 1::4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US20240150369, Compound 1::US20250270226, Compound 1::US12565502, Compound 1 Cyclin-dependent kinase 7 Homo sapiens 560 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740930 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 US11643416, Compound 2::4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 2::US20250270226, Compound 2::US12565502, Compound 2 Cyclin-dependent kinase 1 Homo sapiens 3.70 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740931 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 US11643416, Compound 2::4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 2::US20250270226, Compound 2::US12565502, Compound 2 CDK3/Cyclin E Homo sapiens 2.80 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740932 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 US11643416, Compound 2::4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 2::US20250270226, Compound 2::US12565502, Compound 2 Cyclin-dependent kinase 5 Homo sapiens 1.40 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740933 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 US11643416, Compound 2::4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 2::US20250270226, Compound 2::US12565502, Compound 2 Cyclin-dependent kinase 5 activator 1 (CDK5-P25) Homo sapiens 1.30 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=951&target=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 1 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 1UNL,1UNH,1UNG,7VDS,7VDR,7VDQ,7VDP,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 740934 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 US11643416, Compound 2::4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 2::US20250270226, Compound 2::US12565502, Compound 2 Cyclin-dependent kinase 7 Homo sapiens 200 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740935 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 US11643416, Compound 3::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 3::US20250270226, Compound 3::US12565502, Compound 3 Cyclin-dependent kinase 1 Homo sapiens 33.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740936 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 US11643416, Compound 3::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 3::US20250270226, Compound 3::US12565502, Compound 3 CDK3/Cyclin E Homo sapiens 9.90 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740937 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 US11643416, Compound 3::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 3::US20250270226, Compound 3::US12565502, Compound 3 Cyclin-dependent kinase 5 Homo sapiens 17.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740938 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 US11643416, Compound 3::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 3::US20250270226, Compound 3::US12565502, Compound 3 Cyclin-dependent kinase 5 activator 1 (CDK5-P25) Homo sapiens 14.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=951&target=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 1 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 1UNL,1UNH,1UNG,7VDS,7VDR,7VDQ,7VDP,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 740939 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 US11643416, Compound 3::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 3::US20250270226, Compound 3::US12565502, Compound 3 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740940 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 |c:16| InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 US11643416, Compound 4::4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 4::US20250270226, Compound 4::US12565502, Compound 4 Cyclin-dependent kinase 1 Homo sapiens 89.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740941 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 |c:16| InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 US11643416, Compound 4::4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 4::US20250270226, Compound 4::US12565502, Compound 4 CDK3/Cyclin E Homo sapiens 5.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740942 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 |c:16| InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 US11643416, Compound 4::4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 4::US20250270226, Compound 4::US12565502, Compound 4 Cyclin-dependent kinase 5 Homo sapiens 6.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740943 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 |c:16| InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 US11643416, Compound 4::4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 4::US20250270226, Compound 4::US12565502, Compound 4 Cyclin-dependent kinase 7 Homo sapiens 230 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740944 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 US11643416, Compound 12::4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 12::US20250270226, Compound 12::US12565502, Compound 12 Cyclin-dependent kinase 1 Homo sapiens 88.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740945 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 US11643416, Compound 12::4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 12::US20250270226, Compound 12::US12565502, Compound 12 CDK3/Cyclin E Homo sapiens 59.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740946 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 US11643416, Compound 12::4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 12::US20250270226, Compound 12::US12565502, Compound 12 Cyclin-dependent kinase 5 Homo sapiens 120 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740947 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 US11643416, Compound 12::4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 12::US20250270226, Compound 12::US12565502, Compound 12 Cyclin-dependent kinase 5 activator 1 (CDK5-P25) Homo sapiens 140 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=951&target=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 1 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 1UNL,1UNH,1UNG,7VDS,7VDR,7VDQ,7VDP,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 740948 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 US11643416, Compound 12::4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 12::US20250270226, Compound 12::US12565502, Compound 12 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740949 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601938 US11643416, Compound 18::(R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 18::US20250270226, Compound 18::US12565502, Compound 18 Cyclin-dependent kinase 1 Homo sapiens 20.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740950 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601938 US11643416, Compound 18::(R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 18::US20250270226, Compound 18::US12565502, Compound 18 CDK3/Cyclin E Homo sapiens 18.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740951 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601938 US11643416, Compound 18::(R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 18::US20250270226, Compound 18::US12565502, Compound 18 Cyclin-dependent kinase 5 Homo sapiens 16.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740952 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601938 US11643416, Compound 18::(R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 18::US20250270226, Compound 18::US12565502, Compound 18 Cyclin-dependent kinase 5 activator 1 (CDK5-P25) Homo sapiens 17.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=951&target=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 1 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 1UNL,1UNH,1UNG,7VDS,7VDR,7VDQ,7VDP,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 740953 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601938 US11643416, Compound 18::(R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 18::US20250270226, Compound 18::US12565502, Compound 18 Cyclin-dependent kinase 7 Homo sapiens 840 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740954 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |r| InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26) ZJKDYTFNXUBLEQ-UHFFFAOYSA-N 601939 US11643416, Compound 19::(S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 19::US20250270226, Compound 19::US12565502, Compound 19 Cyclin-dependent kinase 1 Homo sapiens 40.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740955 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |r| InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26) ZJKDYTFNXUBLEQ-UHFFFAOYSA-N 601939 US11643416, Compound 19::(S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 19::US20250270226, Compound 19::US12565502, Compound 19 CDK3/Cyclin E Homo sapiens 34.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740956 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |r| InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26) ZJKDYTFNXUBLEQ-UHFFFAOYSA-N 601939 US11643416, Compound 19::(S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 19::US20250270226, Compound 19::US12565502, Compound 19 Cyclin-dependent kinase 5 Homo sapiens 50.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740957 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |r| InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26) ZJKDYTFNXUBLEQ-UHFFFAOYSA-N 601939 US11643416, Compound 19::(S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 19::US20250270226, Compound 19::US12565502, Compound 19 Cyclin-dependent kinase 5 activator 1 (CDK5-P25) Homo sapiens 62.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=951&target=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-dependent+kinase+5+activator+1+%28CDK5-P25%29&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 1 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 1UNL,1UNH,1UNG,7VDS,7VDR,7VDQ,7VDP,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 740958 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |r| InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26) ZJKDYTFNXUBLEQ-UHFFFAOYSA-N 601939 US11643416, Compound 19::(S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 19::US20250270226, Compound 19::US12565502, Compound 19 Cyclin-dependent kinase 7 Homo sapiens 800 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740959 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |c:2| InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 US11643416, Compound 5::4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 5::US20250270226, Compound 5::US12565502, Compound 5 Cyclin-dependent kinase 1 Homo sapiens 11.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740960 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |c:2| InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 US11643416, Compound 5::4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 5::US20250270226, Compound 5::US12565502, Compound 5 CDK3/Cyclin E Homo sapiens 23.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740961 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |c:2| InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 US11643416, Compound 5::4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 5::US20250270226, Compound 5::US12565502, Compound 5 Cyclin-dependent kinase 5 Homo sapiens 30.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740962 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |c:2| InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 US11643416, Compound 5::4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 5::US20250270226, Compound 5::US12565502, Compound 5 Cyclin-dependent kinase 7 Homo sapiens 875 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740963 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601941 US11643416, Compound 23::(S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 23::US20250270226, Compound 23::US12565502, Compound 23 Cyclin-dependent kinase 1 Homo sapiens 20.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740964 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601941 US11643416, Compound 23::(S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 23::US20250270226, Compound 23::US12565502, Compound 23 CDK3/Cyclin E Homo sapiens 6.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740965 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601941 US11643416, Compound 23::(S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 23::US20250270226, Compound 23::US12565502, Compound 23 Cyclin-dependent kinase 5 Homo sapiens 12.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740966 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 |r| InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27) FKAJEPVSQITQLJ-UHFFFAOYSA-N 601941 US11643416, Compound 23::(S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 23::US20250270226, Compound 23::US12565502, Compound 23 Cyclin-dependent kinase 7 Homo sapiens 682 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740967 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 US11643416, Compound 42::4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 42::US20250270226, Compound 42::US12565502, Compound 42 Cyclin-dependent kinase 1 Homo sapiens 7.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740968 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 US11643416, Compound 42::4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 42::US20250270226, Compound 42::US12565502, Compound 42 CDK3/Cyclin E Homo sapiens 10.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740969 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 US11643416, Compound 42::4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 42::US20250270226, Compound 42::US12565502, Compound 42 Cyclin-dependent kinase 5 Homo sapiens 2.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740970 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 US11643416, Compound 42::4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 42::US20250270226, Compound 42::US12565502, Compound 42 Cyclin-dependent kinase 7 Homo sapiens 83.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740971 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 US11643416, Compound 43::4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 43::US20250270226, Compound 43::US12565502, Compound 43 Cyclin-dependent kinase 1 Homo sapiens 33.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740972 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 US11643416, Compound 43::4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 43::US20250270226, Compound 43::US12565502, Compound 43 CDK3/Cyclin E Homo sapiens 29.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740973 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 US11643416, Compound 43::4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 43::US20250270226, Compound 43::US12565502, Compound 43 Cyclin-dependent kinase 5 Homo sapiens 15.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740974 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 US11643416, Compound 43::4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US20240150369, Compound 43::US20250270226, Compound 43::US12565502, Compound 43 Cyclin-dependent kinase 7 Homo sapiens 250 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740975 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 |t:1| InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 US11643416, Compound 45::4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 45::US20250270226, Compound 45::US12565502, Compound 45 Cyclin-dependent kinase 1 Homo sapiens 108 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740976 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 |t:1| InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 US11643416, Compound 45::4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 45::US20250270226, Compound 45::US12565502, Compound 45 CDK3/Cyclin E Homo sapiens 73.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740977 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 |t:1| InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 US11643416, Compound 45::4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 45::US20250270226, Compound 45::US12565502, Compound 45 Cyclin-dependent kinase 5 Homo sapiens 48.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740978 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 |t:1| InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 US11643416, Compound 45::4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 45::US20250270226, Compound 45::US12565502, Compound 45 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740979 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |t:2| InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 US11643416, Compound 46::4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 46::US20250270226, Compound 46::US12565502, Compound 46 Cyclin-dependent kinase 1 Homo sapiens 14.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740980 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |t:2| InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 US11643416, Compound 46::4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 46::US20250270226, Compound 46::US12565502, Compound 46 CDK3/Cyclin E Homo sapiens 13.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740981 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |t:2| InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 US11643416, Compound 46::4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 46::US20250270226, Compound 46::US12565502, Compound 46 Cyclin-dependent kinase 5 Homo sapiens 11.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740982 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 |t:2| InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 US11643416, Compound 46::4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US20240150369, Compound 46::US20250270226, Compound 46::US12565502, Compound 46 Cyclin-dependent kinase 7 Homo sapiens 723 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740983 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 US11643416, Compound 49::7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 49::US20250270226, Compound 49::US12565502, Compound 49 Cyclin-dependent kinase 1 Homo sapiens 478 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740984 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 US11643416, Compound 49::7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 49::US20250270226, Compound 49::US12565502, Compound 49 CDK3/Cyclin E Homo sapiens 115 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740985 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 US11643416, Compound 49::7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 49::US20250270226, Compound 49::US12565502, Compound 49 Cyclin-dependent kinase 5 Homo sapiens 105 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740986 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 US11643416, Compound 49::7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 49::US20250270226, Compound 49::US12565502, Compound 49 Cyclin-dependent kinase 7 Homo sapiens 242 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740987 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 US11643416, Compound 50::6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 50::US20250270226, Compound 50::US12565502, Compound 50 Cyclin-dependent kinase 1 Homo sapiens 78.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740988 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 US11643416, Compound 50::6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 50::US20250270226, Compound 50::US12565502, Compound 50 CDK3/Cyclin E Homo sapiens 28.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740989 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 US11643416, Compound 50::6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 50::US20250270226, Compound 50::US12565502, Compound 50 Cyclin-dependent kinase 5 Homo sapiens 71.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740990 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 US11643416, Compound 50::6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 50::US20250270226, Compound 50::US12565502, Compound 50 Cyclin-dependent kinase 7 Homo sapiens 118 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740991 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 US11643416, Compound 51::2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 51::US20250270226, Compound 51::US12565502, Compound 51 Cyclin-dependent kinase 1 Homo sapiens 31.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740992 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 US11643416, Compound 51::2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 51::US20250270226, Compound 51::US12565502, Compound 51 CDK3/Cyclin E Homo sapiens 23.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740993 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 US11643416, Compound 51::2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 51::US20250270226, Compound 51::US12565502, Compound 51 Cyclin-dependent kinase 5 Homo sapiens 7.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740994 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 US11643416, Compound 51::2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 51::US20250270226, Compound 51::US12565502, Compound 51 Cyclin-dependent kinase 7 Homo sapiens 66.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740995 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 US11643416, Compound 52::7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 52::US20250270226, Compound 52::US12565502, Compound 52 Cyclin-dependent kinase 1 Homo sapiens 242 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 740996 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 US11643416, Compound 52::7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 52::US20250270226, Compound 52::US12565502, Compound 52 CDK3/Cyclin E Homo sapiens 75.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 740997 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 US11643416, Compound 52::7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 52::US20250270226, Compound 52::US12565502, Compound 52 Cyclin-dependent kinase 5 Homo sapiens 84.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 740998 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 US11643416, Compound 52::7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 52::US20250270226, Compound 52::US12565502, Compound 52 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 740999 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 US11643416, Compound 53::6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 53::US20250270226, Compound 53::US12565502, Compound 53 Cyclin-dependent kinase 1 Homo sapiens 27.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741000 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 US11643416, Compound 53::6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 53::US20250270226, Compound 53::US12565502, Compound 53 CDK3/Cyclin E Homo sapiens 10.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 741001 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 US11643416, Compound 53::6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 53::US20250270226, Compound 53::US12565502, Compound 53 Cyclin-dependent kinase 5 Homo sapiens 4.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741002 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 US11643416, Compound 53::6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US20240150369, Compound 53::US20250270226, Compound 53::US12565502, Compound 53 Cyclin-dependent kinase 7 Homo sapiens 615 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741003 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 US11643416, Compound 54::2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 54::US20250270226, Compound 54::US12565502, Compound 54 Cyclin-dependent kinase 1 Homo sapiens 12.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741004 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 US11643416, Compound 54::2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 54::US20250270226, Compound 54::US12565502, Compound 54 CDK3/Cyclin E Homo sapiens 8.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 741005 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 US11643416, Compound 54::2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 54::US20250270226, Compound 54::US12565502, Compound 54 Cyclin-dependent kinase 5 Homo sapiens 3.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741006 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 US11643416, Compound 54::2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 54::US20250270226, Compound 54::US12565502, Compound 54 Cyclin-dependent kinase 7 Homo sapiens 144 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741007 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 US11643416, Compound 55::2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US20240150369, Compound 55::US20250270226, Compound 55::US12565502, Compound 55 Cyclin-dependent kinase 1 Homo sapiens 5.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741008 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 US11643416, Compound 55::2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US20240150369, Compound 55::US20250270226, Compound 55::US12565502, Compound 55 CDK3/Cyclin E Homo sapiens 6.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 741009 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 US11643416, Compound 55::2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US20240150369, Compound 55::US20250270226, Compound 55::US12565502, Compound 55 Cyclin-dependent kinase 5 Homo sapiens 1.000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741010 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 US11643416, Compound 55::2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US20240150369, Compound 55::US20250270226, Compound 55::US12565502, Compound 55 Cyclin-dependent kinase 7 Homo sapiens 27.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741011 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 US11643416, Compound 59::8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 59::US20250270226, Compound 59::US12565502, Compound 59 Cyclin-dependent kinase 1 Homo sapiens 42.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741012 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 US11643416, Compound 59::8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 59::US20250270226, Compound 59::US12565502, Compound 59 CDK3/Cyclin E Homo sapiens 57.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 741013 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 US11643416, Compound 59::8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 59::US20250270226, Compound 59::US12565502, Compound 59 Cyclin-dependent kinase 5 Homo sapiens 6.00 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741014 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 US11643416, Compound 59::8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 59::US20250270226, Compound 59::US12565502, Compound 59 Cyclin-dependent kinase 7 Homo sapiens 16.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741015 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 US11643416, Compound 61::7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 61::US20250270226, Compound 61::US12565502, Compound 61 Cyclin-dependent kinase 1 Homo sapiens 133 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741016 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 US11643416, Compound 61::7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 61::US20250270226, Compound 61::US12565502, Compound 61 CDK3/Cyclin E Homo sapiens 58.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 741017 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 US11643416, Compound 61::7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 61::US20250270226, Compound 61::US12565502, Compound 61 Cyclin-dependent kinase 5 Homo sapiens 72.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741018 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 US11643416, Compound 61::7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 61::US20250270226, Compound 61::US12565502, Compound 61 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741019 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 US11643416, Compound 62::N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 62::US20250270226, Compound 62::US12565502, Compound 62 Cyclin-dependent kinase 1 Homo sapiens 727 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741020 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 US11643416, Compound 62::N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 62::US20250270226, Compound 62::US12565502, Compound 62 CDK3/Cyclin E Homo sapiens 187 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 741021 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 US11643416, Compound 62::N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 62::US20250270226, Compound 62::US12565502, Compound 62 Cyclin-dependent kinase 5 Homo sapiens 131 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741022 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 US11643416, Compound 62::N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 62::US20250270226, Compound 62::US12565502, Compound 62 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741023 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 US11643416, Compound 63::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 63::US20250270226, Compound 63::US12565502, Compound 63 Cyclin-dependent kinase 1 Homo sapiens 574 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741024 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 US11643416, Compound 63::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 63::US20250270226, Compound 63::US12565502, Compound 63 CDK3/Cyclin E Homo sapiens 96.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 741025 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 US11643416, Compound 63::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 63::US20250270226, Compound 63::US12565502, Compound 63 Cyclin-dependent kinase 5 Homo sapiens 78.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741026 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 US11643416, Compound 63::4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 63::US20250270226, Compound 63::US12565502, Compound 63 Cyclin-dependent kinase 7 Homo sapiens 579 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741027 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 US11643416, Compound 64::N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 64::US20250270226, Compound 64::US12565502, Compound 64 Cyclin-dependent kinase 1 Homo sapiens 505 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741028 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 US11643416, Compound 64::N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 64::US20250270226, Compound 64::US12565502, Compound 64 CDK3/Cyclin E Homo sapiens 105 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 741029 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 US11643416, Compound 64::N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 64::US20250270226, Compound 64::US12565502, Compound 64 Cyclin-dependent kinase 5 Homo sapiens 65.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741030 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 US11643416, Compound 64::N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US20240150369, Compound 64::US20250270226, Compound 64::US12565502, Compound 64 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741031 CNC(=O)Nc1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H24N8O2/c1-22-20(31)25-15-7-5-14(6-8-15)24-19-23-12-13-11-16-27-28-18(30)21(9-3-2-4-10-21)29(16)17(13)26-19/h5-8,11-12,27H,2-4,9-10H2,1H3,(H,28,30)(H2,22,25,31)(H,23,24,26) CVRCXPPQBIKZFQ-UHFFFAOYSA-N 601959 US11643416, Compound 68::1-methyl-3-(4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)phenyl)urea::US20240150369, Compound 68::US20250270226, Compound 68::US12565502, Compound 68 Cyclin-dependent kinase 1 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601959&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360296 482093041 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741032 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)C(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C27H33N7O2/c1-18-24(35)30-22-16-20-17-28-26(31-23(20)34(22)27(18)10-4-3-5-11-27)29-21-8-6-19(7-9-21)25(36)33-14-12-32(2)13-15-33/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,30,35)(H,28,29,31) QWDLZMUWYCLKFF-UHFFFAOYSA-N 601960 US11643416, Compound 71::8'-methyl-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US20240150369, Compound 71::US20250270226, Compound 71::US12565502, Compound 71 Cyclin-dependent kinase 1 Homo sapiens 15.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601960&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360113 482093042 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741033 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 US11643416, Compound 74::7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 74::US20250270226, Compound 74::US12565502, Compound 74 Cyclin-dependent kinase 1 Homo sapiens 258 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741034 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 US11643416, Compound 74::7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 74::US20250270226, Compound 74::US12565502, Compound 74 CDK3/Cyclin E Homo sapiens 106 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000091&target=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=CDK3%2FCyclin+E&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 2 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 9NYQ,9OB6,9OB5,9OB4,9OB3,9OB2,9NYR,9GP3,9GOP,9D0X,9D0W,9D0V,8VQ4,8VQ3,1W98,9BJC,8H6T,8H6P G1/S-specific cyclin-E1 CCNE1_HUMAN P24864 A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 8H4R,7XQK Cyclin-dependent kinase 3 CDK3_HUMAN Q00526 741035 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 US11643416, Compound 74::7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 74::US20250270226, Compound 74::US12565502, Compound 74 Cyclin-dependent kinase 5 Homo sapiens 92.0 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741036 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 US11643416, Compound 74::7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 74::US20250270226, Compound 74::US12565502, Compound 74 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741037 CS(=N)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H23N7O2S/c1-30(21,29)15-7-5-14(6-8-15)23-19-22-12-13-11-16-25-26-18(28)20(9-3-2-4-10-20)27(16)17(13)24-19/h5-8,11-12,21,25H,2-4,9-10H2,1H3,(H,26,28)(H,22,23,24) WHDHBZVTAJDTDO-UHFFFAOYSA-N 601962 US11643416, Compound 79::7'-((4-(S- methylsulfonimidoyl)phenyl)amino)- 1',2'-dihydro-3'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US20240150369, Compound 79::US20250270226, Compound 79::US12565502, Compound 79 Cyclin-dependent kinase 1 Homo sapiens 146 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601962&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360343 482093044 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741038 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3NNC(=O)C4(CCCCC4)n3c2n1 InChI=1S/C19H21N7O3S/c20-13-4-6-14(7-5-13)30(28,29)25-18-21-11-12-10-15-23-24-17(27)19(8-2-1-3-9-19)26(15)16(12)22-18/h4-7,10-11,23H,1-3,8-9,20H2,(H,24,27)(H,21,22,25) QGIFQLWCNWTFNA-UHFFFAOYSA-N 601963 US11643416, Compound 84::4-amino-N-(3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)benzenesulfonamide::US20240150369, Compound 84::US20250270226, Compound 84::US12565502, Compound 84 Cyclin-dependent kinase 1 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601963&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360418 482093045 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741039 Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3C(=O)NCC4(CCCCC4)n3c2n1 InChI=1S/C20H22N6O3S/c21-14-4-6-15(7-5-14)30(28,29)25-19-22-11-13-10-16-18(27)23-12-20(8-2-1-3-9-20)26(16)17(13)24-19/h4-7,10-11H,1-3,8-9,12,21H2,(H,23,27)(H,22,24,25) YJGKHEQGTLAYHU-UHFFFAOYSA-N 601964 US11643416, Compound 91::4-amino-N-(6'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)benzenesulfonamide::US20240150369, Compound 91::US20250270226, Compound 91::US12565502, Compound 91 Cyclin-dependent kinase 1 Homo sapiens >1000 US Patent 10.7270/Q21N863B aid1798225 US12565502 Strum, JC 3/3/2026 7/13/2026 Pharmacosmos Holding http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601964&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 162360287 482093046 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764