BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 741261 N#Cc1ccc(-c2ccc(C[C@H](C#N)NC(=O)[C@@H]3C[C@H]4COC[C@H]4N3)cc2)cc1 InChI=1S/C23H22N4O2/c24-11-16-3-7-18(8-4-16)17-5-1-15(2-6-17)9-20(12-25)26-23(28)21-10-19-13-29-14-22(19)27-21/h1-8,19-22,27H,9-10,13-14H2,(H,26,28) BVVHXTPPMMDWNC-UHFFFAOYSA-N 794698 US20260062420, Compound IWD-004 Dipeptidyl peptidase 1 Mus musculus 209 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794698 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794698&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423164 528826161 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741262 Cn1c2c(oc1=O)C=CC(c1ccc(C[C@@H](C#N)NC(=O)[C@H]3C[C@@H]4COC[C@@H]4N3)cc1)C2 InChI=1S/C24H26N4O4/c1-28-21-10-16(6-7-22(21)32-24(28)30)15-4-2-14(3-5-15)8-18(11-25)26-23(29)19-9-17-12-31-13-20(17)27-19/h2-7,16-20,27H,8-10,12-13H2,1H3,(H,26,29) AZOLUAKJGWMEOE-UHFFFAOYSA-N 795095 US20260062420, Compound IWD-005 Dipeptidyl peptidase 1 Mus musculus 45.6 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795095&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423169 528826558 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741263 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28) AEXFXNFMSAAELR-UHFFFAOYSA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11680049, Example 2::US11655221, Example 2::US20230278969, Example 2::US20240083888, Compound AZD7986::US20250101011, Compound AZD7986::US20260062420, Compound Table16.1 Dipeptidyl peptidase 1 Mus musculus 24.3 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741264 N#Cc1ccc(-c2ccc(C[C@H](C#N)NC(=O)[C@@H]3C[C@H]4COC[C@H]4N3)cc2)cc1 InChI=1S/C23H22N4O2/c24-11-16-3-7-18(8-4-16)17-5-1-15(2-6-17)9-20(12-25)26-23(28)21-10-19-13-29-14-22(19)27-21/h1-8,19-22,27H,9-10,13-14H2,(H,26,28) BVVHXTPPMMDWNC-UHFFFAOYSA-N 794698 US20260062420, Compound IWD-004 Dipeptidyl peptidase 1 Homo sapiens 245 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=794698 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=794698&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423164 528826161 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741265 Cn1c2c(oc1=O)C=CC(c1ccc(C[C@@H](C#N)NC(=O)[C@H]3C[C@@H]4COC[C@@H]4N3)cc1)C2 InChI=1S/C24H26N4O4/c1-28-21-10-16(6-7-22(21)32-24(28)30)15-4-2-14(3-5-15)8-18(11-25)26-23(29)19-9-17-12-31-13-20(17)27-19/h2-7,16-20,27H,8-10,12-13H2,1H3,(H,26,29) AZOLUAKJGWMEOE-UHFFFAOYSA-N 795095 US20260062420, Compound IWD-005 Dipeptidyl peptidase 1 Homo sapiens 69.2 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795095&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423169 528826558 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741266 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28) AEXFXNFMSAAELR-UHFFFAOYSA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11680049, Example 2::US11655221, Example 2::US20230278969, Example 2::US20240083888, Compound AZD7986::US20250101011, Compound AZD7986::US20260062420, Compound Table16.1 Dipeptidyl peptidase 1 Homo sapiens 16.0 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741267 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28) AEXFXNFMSAAELR-UHFFFAOYSA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11680049, Example 2::US11655221, Example 2::US20230278969, Example 2::US20240083888, Compound AZD7986::US20250101011, Compound AZD7986::US20260062420, Compound Table16.1 Dipeptidyl peptidase 1 Homo sapiens 19.7 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741268 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28) AEXFXNFMSAAELR-UHFFFAOYSA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11680049, Example 2::US11655221, Example 2::US20230278969, Example 2::US20240083888, Compound AZD7986::US20250101011, Compound AZD7986::US20260062420, Compound Table16.1 Dipeptidyl peptidase 1 Mus musculus 27.0 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741269 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@H]4C[C@H]4N3)cc2)cc1 InChI=1S/C22H20N4O/c23-12-15-3-7-17(8-4-15)16-5-1-14(2-6-16)9-19(13-24)25-22(27)21-11-18-10-20(18)26-21/h1-8,18-21,26H,9-11H2,(H,25,27) YGNXAEODOHMWOX-UHFFFAOYSA-N 795098 US20260062420, Compound Table16.2 Dipeptidyl peptidase 1 Homo sapiens 140 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795098&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754195 528826561 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741270 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@H]4C[C@H]4N3)cc2)cc1 InChI=1S/C22H20N4O/c23-12-15-3-7-17(8-4-15)16-5-1-14(2-6-16)9-19(13-24)25-22(27)21-11-18-10-20(18)26-21/h1-8,18-21,26H,9-11H2,(H,25,27) YGNXAEODOHMWOX-UHFFFAOYSA-N 795098 US20260062420, Compound Table16.2 Dipeptidyl peptidase 1 Mus musculus 92.4 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795098&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754195 528826561 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741271 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@H]5C[C@H]5N4)cc3)cc21 InChI=1S/C23H22N4O3/c1-27-20-11-15(6-7-21(20)30-23(27)29)14-4-2-13(3-5-14)8-17(12-24)25-22(28)19-10-16-9-18(16)26-19/h2-7,11,16-19,26H,8-10H2,1H3,(H,25,28) YNWZAYBXLGVINY-UHFFFAOYSA-N 795099 US20260062420, Compound Table16.3 Dipeptidyl peptidase 1 Homo sapiens 41.1 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795099&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754248 528826562 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741272 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@H]5C[C@H]5N4)cc3)cc21 InChI=1S/C23H22N4O3/c1-27-20-11-15(6-7-21(20)30-23(27)29)14-4-2-13(3-5-14)8-17(12-24)25-22(28)19-10-16-9-18(16)26-19/h2-7,11,16-19,26H,8-10H2,1H3,(H,25,28) YNWZAYBXLGVINY-UHFFFAOYSA-N 795099 US20260062420, Compound Table16.3 Dipeptidyl peptidase 1 Mus musculus 24.0 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795099&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754248 528826562 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741273 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@H]5C[C@H]5N4)cc3)cc21 InChI=1S/C23H22N4O3/c1-27-20-11-15(6-7-21(20)30-23(27)29)14-4-2-13(3-5-14)8-17(12-24)25-22(28)19-10-16-9-18(16)26-19/h2-7,11,16-19,26H,8-10H2,1H3,(H,25,28) YNWZAYBXLGVINY-UHFFFAOYSA-N 795100 US20260062420, Compound Table16.4 Dipeptidyl peptidase 1 Homo sapiens 30.4 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795100&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754248 528826563 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741274 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@H]5C[C@H]5N4)cc3)cc21 InChI=1S/C23H22N4O3/c1-27-20-11-15(6-7-21(20)30-23(27)29)14-4-2-13(3-5-14)8-17(12-24)25-22(28)19-10-16-9-18(16)26-19/h2-7,11,16-19,26H,8-10H2,1H3,(H,25,28) YNWZAYBXLGVINY-UHFFFAOYSA-N 795100 US20260062420, Compound Table16.4 Dipeptidyl peptidase 1 Mus musculus 19.6 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795100&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754248 528826563 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741275 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@H]4COC[C@H]4N3)cc2)cc1 InChI=1S/C23H22N4O2/c24-11-16-3-7-18(8-4-16)17-5-1-15(2-6-17)9-20(12-25)26-23(28)21-10-19-13-29-14-22(19)27-21/h1-8,19-22,27H,9-10,13-14H2,(H,26,28) BVVHXTPPMMDWNC-UHFFFAOYSA-N 795101 US20260062420, Compound Table16.5 Dipeptidyl peptidase 1 Homo sapiens 269 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795101&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754372 528826564 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741276 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@H]4COC[C@H]4N3)cc2)cc1 InChI=1S/C23H22N4O2/c24-11-16-3-7-18(8-4-16)17-5-1-15(2-6-17)9-20(12-25)26-23(28)21-10-19-13-29-14-22(19)27-21/h1-8,19-22,27H,9-10,13-14H2,(H,26,28) BVVHXTPPMMDWNC-UHFFFAOYSA-N 795101 US20260062420, Compound Table16.5 Dipeptidyl peptidase 1 Mus musculus 209 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795101&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754372 528826564 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741277 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@H]5COC[C@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-21-10-16(6-7-22(21)32-24(28)30)15-4-2-14(3-5-15)8-18(11-25)26-23(29)19-9-17-12-31-13-20(17)27-19/h2-7,10,17-20,27H,8-9,12-13H2,1H3,(H,26,29) NXIQEAQUOGZJGG-UHFFFAOYSA-N 795102 US20260062420, Compound Table16.6 Dipeptidyl peptidase 1 Homo sapiens 69.2 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795102&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754586 528826565 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741278 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@H]5COC[C@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-21-10-16(6-7-22(21)32-24(28)30)15-4-2-14(3-5-15)8-18(11-25)26-23(29)19-9-17-12-31-13-20(17)27-19/h2-7,10,17-20,27H,8-9,12-13H2,1H3,(H,26,29) NXIQEAQUOGZJGG-UHFFFAOYSA-N 795102 US20260062420, Compound Table16.6 Dipeptidyl peptidase 1 Mus musculus 45.6 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795102&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754586 528826565 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741279 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5C[C@@H]5N4)cc3)cc21 InChI=1S/C23H22N4O3/c1-27-20-11-15(6-7-21(20)30-23(27)29)14-4-2-13(3-5-14)8-17(12-24)25-22(28)19-10-16-9-18(16)26-19/h2-7,11,16-19,26H,8-10H2,1H3,(H,25,28) YNWZAYBXLGVINY-UHFFFAOYSA-N 795103 US20260062420, Compound Table16.7 Dipeptidyl peptidase 1 Homo sapiens 189 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795103&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754438 528826566 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741280 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5C[C@@H]5N4)cc3)cc21 InChI=1S/C23H22N4O3/c1-27-20-11-15(6-7-21(20)30-23(27)29)14-4-2-13(3-5-14)8-17(12-24)25-22(28)19-10-16-9-18(16)26-19/h2-7,11,16-19,26H,8-10H2,1H3,(H,25,28) YNWZAYBXLGVINY-UHFFFAOYSA-N 795103 US20260062420, Compound Table16.7 Dipeptidyl peptidase 1 Mus musculus 131 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795103&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754438 528826566 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741281 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5COC[C@@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-21-10-16(6-7-22(21)32-24(28)30)15-4-2-14(3-5-15)8-18(11-25)26-23(29)19-9-17-12-31-13-20(17)27-19/h2-7,10,17-20,27H,8-9,12-13H2,1H3,(H,26,29) NXIQEAQUOGZJGG-UHFFFAOYSA-N 795104 US20260062420, Compound Table16.8 Dipeptidyl peptidase 1 Homo sapiens 940 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795104&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754199 528826567 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741282 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3C[C@@H]4COC[C@@H]4N3)cc2)cc1 InChI=1S/C23H22N4O2/c24-11-16-3-7-18(8-4-16)17-5-1-15(2-6-17)9-20(12-25)26-23(28)21-10-19-13-29-14-22(19)27-21/h1-8,19-22,27H,9-10,13-14H2,(H,26,28) BVVHXTPPMMDWNC-UHFFFAOYSA-N 795105 US20260062420, Compound Table16.9 Dipeptidyl peptidase 1 Homo sapiens 2608 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795105&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754437 528826568 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741283 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC4COCCN4)cc3)cc21 InChI=1S/C23H24N4O4/c1-27-20-11-17(6-7-21(20)31-23(27)29)16-4-2-15(3-5-16)10-18(13-24)26-22(28)12-19-14-30-9-8-25-19/h2-7,11,18-19,25H,8-10,12,14H2,1H3,(H,26,28) MTYVYXGWDWFWKN-UHFFFAOYSA-N 795106 US20260062420, Compound Table16.10 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795106&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754143 528826569 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741284 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC4COCCN4)cc3)cc21 InChI=1S/C23H24N4O4/c1-27-20-11-17(6-7-21(20)31-23(27)29)16-4-2-15(3-5-16)10-18(13-24)26-22(28)12-19-14-30-9-8-25-19/h2-7,11,18-19,25H,8-10,12,14H2,1H3,(H,26,28) MTYVYXGWDWFWKN-UHFFFAOYSA-N 795106 US20260062420, Compound Table16.10 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795106&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754143 528826569 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741285 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NS(N)(=O)=O)cc3)cc21 InChI=1S/C17H16N4O4S/c1-21-15-9-13(6-7-16(15)25-17(21)22)12-4-2-11(3-5-12)8-14(10-18)20-26(19,23)24/h2-7,9,14,20H,8H2,1H3,(H2,19,23,24) ZLNDGJJOYYIOHC-UHFFFAOYSA-N 795107 US20260062420, Compound Table16.11 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795107&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754243 528826570 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741286 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NS(N)(=O)=O)cc3)cc21 InChI=1S/C17H16N4O4S/c1-21-15-9-13(6-7-16(15)25-17(21)22)12-4-2-11(3-5-12)8-14(10-18)20-26(19,23)24/h2-7,9,14,20H,8H2,1H3,(H2,19,23,24) ZLNDGJJOYYIOHC-UHFFFAOYSA-N 795107 US20260062420, Compound Table16.11 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795107&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754243 528826570 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741287 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4(N)CCS(=O)(=O)C4)cc3)cc21 InChI=1S/C22H22N4O5S/c1-26-18-11-16(6-7-19(18)31-21(26)28)15-4-2-14(3-5-15)10-17(12-23)25-20(27)22(24)8-9-32(29,30)13-22/h2-7,11,17H,8-10,13,24H2,1H3,(H,25,27) ZKVUNOQEHQPORH-UHFFFAOYSA-N 795108 US20260062420, Compound Table16.12 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795108&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754611 528826571 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741288 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4(N)CCS(=O)(=O)C4)cc3)cc21 InChI=1S/C22H22N4O5S/c1-26-18-11-16(6-7-19(18)31-21(26)28)15-4-2-14(3-5-15)10-17(12-23)25-20(27)22(24)8-9-32(29,30)13-22/h2-7,11,17H,8-10,13,24H2,1H3,(H,25,27) ZKVUNOQEHQPORH-UHFFFAOYSA-N 795108 US20260062420, Compound Table16.12 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795108&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754611 528826571 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741289 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CS(=O)(=O)CCN4)cc3)cc21 InChI=1S/C22H22N4O5S/c1-26-19-11-16(6-7-20(19)31-22(26)28)15-4-2-14(3-5-15)10-17(12-23)25-21(27)18-13-32(29,30)9-8-24-18/h2-7,11,17-18,24H,8-10,13H2,1H3,(H,25,27) XEKVSSZSSARVCL-UHFFFAOYSA-N 795109 US20260062420, Compound Table16.13 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795109&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754214 528826572 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741290 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CS(=O)(=O)CCN4)cc3)cc21 InChI=1S/C22H22N4O5S/c1-26-19-11-16(6-7-20(19)31-22(26)28)15-4-2-14(3-5-15)10-17(12-23)25-21(27)18-13-32(29,30)9-8-24-18/h2-7,11,17-18,24H,8-10,13H2,1H3,(H,25,27) XEKVSSZSSARVCL-UHFFFAOYSA-N 795109 US20260062420, Compound Table16.13 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795109&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754214 528826572 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741291 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CC5CCN4CC5)cc3)cc21 InChI=1S/C25H26N4O3/c1-28-21-14-19(6-7-23(21)32-25(28)31)18-4-2-16(3-5-18)12-20(15-26)27-24(30)22-13-17-8-10-29(22)11-9-17/h2-7,14,17,20,22H,8-13H2,1H3,(H,27,30) JREFIICDMVVDNT-UHFFFAOYSA-N 795110 US20260062420, Compound Table16.14 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795110&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754719 528826573 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741292 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CC5CCN4CC5)cc3)cc21 InChI=1S/C25H26N4O3/c1-28-21-14-19(6-7-23(21)32-25(28)31)18-4-2-16(3-5-18)12-20(15-26)27-24(30)22-13-17-8-10-29(22)11-9-17/h2-7,14,17,20,22H,8-13H2,1H3,(H,27,30) JREFIICDMVVDNT-UHFFFAOYSA-N 795110 US20260062420, Compound Table16.14 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795110&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754719 528826573 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741293 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNCCN4)cc3)cc21 InChI=1S/C22H23N5O3/c1-27-19-11-16(6-7-20(19)30-22(27)29)15-4-2-14(3-5-15)10-17(12-23)26-21(28)18-13-24-8-9-25-18/h2-7,11,17-18,24-25H,8-10,13H2,1H3,(H,26,28) QIZIVIVWLYUMLM-UHFFFAOYSA-N 795111 US20260062420, Compound Table16.15 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795111&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754602 528826574 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741294 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNCCN4)cc3)cc21 InChI=1S/C22H23N5O3/c1-27-19-11-16(6-7-20(19)30-22(27)29)15-4-2-14(3-5-15)10-17(12-23)26-21(28)18-13-24-8-9-25-18/h2-7,11,17-18,24-25H,8-10,13H2,1H3,(H,26,28) QIZIVIVWLYUMLM-UHFFFAOYSA-N 795111 US20260062420, Compound Table16.15 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795111&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754602 528826574 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741295 Cn1c(=O)oc2ccc(-c3ccc(CC(C#N)NC(=O)[C@H]4CCNC[C@@H]4N)cc3)cc21 InChI=1S/C23H25N5O3/c1-28-20-11-16(6-7-21(20)31-23(28)30)15-4-2-14(3-5-15)10-17(12-24)27-22(29)18-8-9-26-13-19(18)25/h2-7,11,17-19,26H,8-10,13,25H2,1H3,(H,27,29) RCPZRIKXXMXBCA-UHFFFAOYSA-N 795112 US20260062420, Compound Table16.16 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795112&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754157 528826575 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741296 Cn1c(=O)oc2ccc(-c3ccc(CC(C#N)NC(=O)[C@H]4CCNC[C@@H]4N)cc3)cc21 InChI=1S/C23H25N5O3/c1-28-20-11-16(6-7-21(20)31-23(28)30)15-4-2-14(3-5-15)10-17(12-24)27-22(29)18-8-9-26-13-19(18)25/h2-7,11,17-19,26H,8-10,13,25H2,1H3,(H,27,29) RCPZRIKXXMXBCA-UHFFFAOYSA-N 795112 US20260062420, Compound Table16.16 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795112&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754157 528826575 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741297 Cn1c(=O)oc2ccc(-c3ccc(CC(C#N)NC(=O)[C@H]4CCNC[C@H]4N)cc3)cc21 InChI=1S/C23H25N5O3/c1-28-20-11-16(6-7-21(20)31-23(28)30)15-4-2-14(3-5-15)10-17(12-24)27-22(29)18-8-9-26-13-19(18)25/h2-7,11,17-19,26H,8-10,13,25H2,1H3,(H,27,29) RCPZRIKXXMXBCA-UHFFFAOYSA-N 795113 US20260062420, Compound Table16.17 Dipeptidyl peptidase 1 Homo sapiens 1308 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795113&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754690 528826576 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741298 Cn1c(=O)oc2ccc(-c3ccc(CC(C#N)NC(=O)[C@H]4CCNC[C@H]4N)cc3)cc21 InChI=1S/C23H25N5O3/c1-28-20-11-16(6-7-21(20)31-23(28)30)15-4-2-14(3-5-15)10-17(12-24)27-22(29)18-8-9-26-13-19(18)25/h2-7,11,17-19,26H,8-10,13,25H2,1H3,(H,27,29) RCPZRIKXXMXBCA-UHFFFAOYSA-N 795113 US20260062420, Compound Table16.17 Dipeptidyl peptidase 1 Mus musculus 2433 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795113&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754690 528826576 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741299 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC4(N)CCOC4)cc3)cc21 InChI=1S/C23H24N4O4/c1-27-19-11-17(6-7-20(19)31-22(27)29)16-4-2-15(3-5-16)10-18(13-24)26-21(28)12-23(25)8-9-30-14-23/h2-7,11,18H,8-10,12,14,25H2,1H3,(H,26,28) QSNKOGLAFICFRT-UHFFFAOYSA-N 795114 US20260062420, Compound Table16.18 Dipeptidyl peptidase 1 Homo sapiens 2545 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795114&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754552 528826577 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741300 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC4(N)CCOC4)cc3)cc21 InChI=1S/C23H24N4O4/c1-27-19-11-17(6-7-20(19)31-22(27)29)16-4-2-15(3-5-16)10-18(13-24)26-21(28)12-23(25)8-9-30-14-23/h2-7,11,18H,8-10,12,14,25H2,1H3,(H,26,28) QSNKOGLAFICFRT-UHFFFAOYSA-N 795114 US20260062420, Compound Table16.18 Dipeptidyl peptidase 1 Mus musculus 3294 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795114&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754552 528826577 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741301 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4COCCN4)cc3)cc21 InChI=1S/C22H22N4O4/c1-26-19-11-16(6-7-20(19)30-22(26)28)15-4-2-14(3-5-15)10-17(12-23)25-21(27)18-13-29-9-8-24-18/h2-7,11,17-18,24H,8-10,13H2,1H3,(H,25,27) CFSDDBYDSJWZGS-UHFFFAOYSA-N 795115 US20260062420, Compound Table16.19 Dipeptidyl peptidase 1 Homo sapiens 537 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795115&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754698 528826578 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741302 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4COCCN4)cc3)cc21 InChI=1S/C22H22N4O4/c1-26-19-11-16(6-7-20(19)30-22(26)28)15-4-2-14(3-5-15)10-17(12-23)25-21(27)18-13-29-9-8-24-18/h2-7,11,17-18,24H,8-10,13H2,1H3,(H,25,27) CFSDDBYDSJWZGS-UHFFFAOYSA-N 795115 US20260062420, Compound Table16.19 Dipeptidyl peptidase 1 Mus musculus 306 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795115&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754698 528826578 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741303 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4(C)CNCCO4)cc3)cc21 InChI=1S/C23H24N4O4/c1-23(14-25-9-10-30-23)21(28)26-18(13-24)11-15-3-5-16(6-4-15)17-7-8-20-19(12-17)27(2)22(29)31-20/h3-8,12,18,25H,9-11,14H2,1-2H3,(H,26,28) ZEVDMDLBRAVQAU-UHFFFAOYSA-N 795116 US20260062420, Compound Table16.20 Dipeptidyl peptidase 1 Homo sapiens 2176 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795116&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754610 528826579 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741304 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4(C)CNCCO4)cc3)cc21 InChI=1S/C23H24N4O4/c1-23(14-25-9-10-30-23)21(28)26-18(13-24)11-15-3-5-16(6-4-15)17-7-8-20-19(12-17)27(2)22(29)31-20/h3-8,12,18,25H,9-11,14H2,1-2H3,(H,26,28) ZEVDMDLBRAVQAU-UHFFFAOYSA-N 795116 US20260062420, Compound Table16.20 Dipeptidyl peptidase 1 Mus musculus 3164 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795116&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754610 528826579 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741305 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC4CCCN4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-20-12-17(8-9-21(20)30-23(27)29)16-6-4-15(5-7-16)11-19(14-24)26-22(28)13-18-3-2-10-25-18/h4-9,12,18-19,25H,2-3,10-11,13H2,1H3,(H,26,28) WCNYMIHCUFTPTQ-UHFFFAOYSA-N 795117 US20260062420, Compound Table16.21 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795117&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754299 528826580 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741306 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC4CCCN4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-20-12-17(8-9-21(20)30-23(27)29)16-6-4-15(5-7-16)11-19(14-24)26-22(28)13-18-3-2-10-25-18/h4-9,12,18-19,25H,2-3,10-11,13H2,1H3,(H,26,28) WCNYMIHCUFTPTQ-UHFFFAOYSA-N 795117 US20260062420, Compound Table16.21 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795117&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754299 528826580 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741307 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCC(N)C4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-20-12-16(7-9-21(20)30-23(27)29)15-4-2-14(3-5-15)10-19(13-24)26-22(28)17-6-8-18(25)11-17/h2-5,7,9,12,17-19H,6,8,10-11,25H2,1H3,(H,26,28) ANJXTERUFIFIOG-UHFFFAOYSA-N 795118 US20260062420, Compound Table16.22 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795118&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423170 528826581 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741308 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCC(N)C4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-20-12-16(7-9-21(20)30-23(27)29)15-4-2-14(3-5-15)10-19(13-24)26-22(28)17-6-8-18(25)11-17/h2-5,7,9,12,17-19H,6,8,10-11,25H2,1H3,(H,26,28) ANJXTERUFIFIOG-UHFFFAOYSA-N 795118 US20260062420, Compound Table16.22 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795118&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423170 528826581 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741309 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCNCC4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-20-13-18(6-7-21(20)30-23(27)29)16-4-2-15(3-5-16)12-19(14-24)26-22(28)17-8-10-25-11-9-17/h2-7,13,17,19,25H,8-12H2,1H3,(H,26,28) CIYOKNMLNWOATL-UHFFFAOYSA-N 795119 US20260062420, Compound Table16.23 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795119&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754593 528826582 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741310 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCNCC4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-20-13-18(6-7-21(20)30-23(27)29)16-4-2-15(3-5-16)12-19(14-24)26-22(28)17-8-10-25-11-9-17/h2-7,13,17,19,25H,8-12H2,1H3,(H,26,28) CIYOKNMLNWOATL-UHFFFAOYSA-N 795119 US20260062420, Compound Table16.23 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795119&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754593 528826582 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741311 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4(CN)CCC4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-19-12-17(7-8-20(19)30-22(27)29)16-5-3-15(4-6-16)11-18(13-24)26-21(28)23(14-25)9-2-10-23/h3-8,12,18H,2,9-11,14,25H2,1H3,(H,26,28) ZATMUQOBLHOXRZ-UHFFFAOYSA-N 795120 US20260062420, Compound Table16.24 Dipeptidyl peptidase 1 Homo sapiens 3656 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795120&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754231 528826583 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741312 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4(CN)CCC4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-19-12-17(7-8-20(19)30-22(27)29)16-5-3-15(4-6-16)11-18(13-24)26-21(28)23(14-25)9-2-10-23/h3-8,12,18H,2,9-11,14,25H2,1H3,(H,26,28) ZATMUQOBLHOXRZ-UHFFFAOYSA-N 795120 US20260062420, Compound Table16.24 Dipeptidyl peptidase 1 Mus musculus 2768 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795120&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754231 528826583 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741313 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCNCC4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-20-13-18(6-7-21(20)30-23(27)29)16-4-2-15(3-5-16)12-19(14-24)26-22(28)17-8-10-25-11-9-17/h2-7,13,17,19,25H,8-12H2,1H3,(H,26,28) CIYOKNMLNWOATL-UHFFFAOYSA-N 795121 US20260062420, Compound Table16.25 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795121&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754593 528826584 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741314 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCNCC4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-20-13-18(6-7-21(20)30-23(27)29)16-4-2-15(3-5-16)12-19(14-24)26-22(28)17-8-10-25-11-9-17/h2-7,13,17,19,25H,8-12H2,1H3,(H,26,28) CIYOKNMLNWOATL-UHFFFAOYSA-N 795121 US20260062420, Compound Table16.25 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795121&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754593 528826584 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741315 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNC4)cc3)cc21 InChI=1S/C21H20N4O3/c1-25-18-9-15(6-7-19(18)28-21(25)27)14-4-2-13(3-5-14)8-17(10-22)24-20(26)16-11-23-12-16/h2-7,9,16-17,23H,8,11-12H2,1H3,(H,24,26) KKQJINBHBJVRRZ-UHFFFAOYSA-N 795122 US20260062420, Compound Table16.26 Dipeptidyl peptidase 1 Homo sapiens 1269 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795122&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754544 528826585 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741316 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNC4)cc3)cc21 InChI=1S/C21H20N4O3/c1-25-18-9-15(6-7-19(18)28-21(25)27)14-4-2-13(3-5-14)8-17(10-22)24-20(26)16-11-23-12-16/h2-7,9,16-17,23H,8,11-12H2,1H3,(H,24,26) KKQJINBHBJVRRZ-UHFFFAOYSA-N 795122 US20260062420, Compound Table16.26 Dipeptidyl peptidase 1 Mus musculus 825 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795122&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754544 528826585 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741317 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNCCS(=O)(=O)C4)cc3)cc21 InChI=1S/C23H24N4O5S/c1-27-20-11-17(6-7-21(20)32-23(27)29)16-4-2-15(3-5-16)10-19(12-24)26-22(28)18-13-25-8-9-33(30,31)14-18/h2-7,11,18-19,25H,8-10,13-14H2,1H3,(H,26,28) KSOJPVHQUZAUTK-UHFFFAOYSA-N 795123 US20260062420, Compound Table16.27 Dipeptidyl peptidase 1 Homo sapiens 4820 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795123&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754125 528826586 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741318 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNCCS(=O)(=O)C4)cc3)cc21 InChI=1S/C23H24N4O5S/c1-27-20-11-17(6-7-21(20)32-23(27)29)16-4-2-15(3-5-16)10-19(12-24)26-22(28)18-13-25-8-9-33(30,31)14-18/h2-7,11,18-19,25H,8-10,13-14H2,1H3,(H,26,28) KSOJPVHQUZAUTK-UHFFFAOYSA-N 795123 US20260062420, Compound Table16.27 Dipeptidyl peptidase 1 Mus musculus 2755 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795123&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754125 528826586 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741319 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4=CS(=O)(=O)CCNC4)cc3)cc21 InChI=1S/C23H22N4O5S/c1-27-20-11-17(6-7-21(20)32-23(27)29)16-4-2-15(3-5-16)10-19(12-24)26-22(28)18-13-25-8-9-33(30,31)14-18/h2-7,11,14,19,25H,8-10,13H2,1H3,(H,26,28) UJYPAVGLJIWAPN-UHFFFAOYSA-N 795124 US20260062420, Compound Table16.28 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795124&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754228 528826587 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741320 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4=CS(=O)(=O)CCNC4)cc3)cc21 InChI=1S/C23H22N4O5S/c1-27-20-11-17(6-7-21(20)32-23(27)29)16-4-2-15(3-5-16)10-19(12-24)26-22(28)18-13-25-8-9-33(30,31)14-18/h2-7,11,14,19,25H,8-10,13H2,1H3,(H,26,28) UJYPAVGLJIWAPN-UHFFFAOYSA-N 795124 US20260062420, Compound Table16.28 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795124&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754228 528826587 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741321 C=C1Oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC4(N)CCS(=O)(=O)C4)cc3)cc2N1C InChI=1S/C24H26N4O4S/c1-16-28(2)21-12-19(7-8-22(21)32-16)18-5-3-17(4-6-18)11-20(14-25)27-23(29)13-24(26)9-10-33(30,31)15-24/h3-8,12,20H,1,9-11,13,15,26H2,2H3,(H,27,29) HLUNGCJVMSHRGG-UHFFFAOYSA-N 795125 US20260062420, Compound Table16.29 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795125&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423171 528826588 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741322 C=C1Oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC4(N)CCS(=O)(=O)C4)cc3)cc2N1C InChI=1S/C24H26N4O4S/c1-16-28(2)21-12-19(7-8-22(21)32-16)18-5-3-17(4-6-18)11-20(14-25)27-23(29)13-24(26)9-10-33(30,31)15-24/h3-8,12,20H,1,9-11,13,15,26H2,2H3,(H,27,29) HLUNGCJVMSHRGG-UHFFFAOYSA-N 795125 US20260062420, Compound Table16.29 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795125&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423171 528826588 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741323 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NS(=O)(=O)CCN)cc3)cc21 InChI=1S/C19H20N4O4S/c1-23-17-11-15(6-7-18(17)27-19(23)24)14-4-2-13(3-5-14)10-16(12-21)22-28(25,26)9-8-20/h2-7,11,16,22H,8-10,20H2,1H3 ZKKLJUBMVHCXPW-UHFFFAOYSA-N 795126 US20260062420, Compound Table16.30 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795126&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754174 528826589 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741324 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NS(=O)(=O)CCN)cc3)cc21 InChI=1S/C19H20N4O4S/c1-23-17-11-15(6-7-18(17)27-19(23)24)14-4-2-13(3-5-14)10-16(12-21)22-28(25,26)9-8-20/h2-7,11,16,22H,8-10,20H2,1H3 ZKKLJUBMVHCXPW-UHFFFAOYSA-N 795126 US20260062420, Compound Table16.30 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795126&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754174 528826589 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741325 CN1COc2ccc(-c3ccc(C[C@@H](C#N)NS(=O)(=O)CCNC4CCCC4)cc3)cc21 InChI=1S/C24H30N4O3S/c1-28-17-31-24-11-10-20(15-23(24)28)19-8-6-18(7-9-19)14-22(16-25)27-32(29,30)13-12-26-21-4-2-3-5-21/h6-11,15,21-22,26-27H,2-5,12-14,17H2,1H3 WJCXMIHPXSZVGQ-UHFFFAOYSA-N 795127 US20260062420, Compound Table16.31 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795127&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423172 528826590 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741326 CN1COc2ccc(-c3ccc(C[C@@H](C#N)NS(=O)(=O)CCNC4CCCC4)cc3)cc21 InChI=1S/C24H30N4O3S/c1-28-17-31-24-11-10-20(15-23(24)28)19-8-6-18(7-9-19)14-22(16-25)27-32(29,30)13-12-26-21-4-2-3-5-21/h6-11,15,21-22,26-27H,2-5,12-14,17H2,1H3 WJCXMIHPXSZVGQ-UHFFFAOYSA-N 795127 US20260062420, Compound Table16.31 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795127&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423172 528826590 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741327 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CC=CCNC4)cc3)cc21 InChI=1S/C24H24N4O3/c1-28-21-13-18(9-10-22(21)31-24(28)30)17-7-5-16(6-8-17)12-20(14-25)27-23(29)19-4-2-3-11-26-15-19/h2-3,5-10,13,19-20,26H,4,11-12,15H2,1H3,(H,27,29) ZQWMJSZYQZDARQ-UHFFFAOYSA-N 795128 US20260062420, Compound Table16.32 Dipeptidyl peptidase 1 Homo sapiens 1758 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795128&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754744 528826591 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741328 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CC=CCNC4)cc3)cc21 InChI=1S/C24H24N4O3/c1-28-21-13-18(9-10-22(21)31-24(28)30)17-7-5-16(6-8-17)12-20(14-25)27-23(29)19-4-2-3-11-26-15-19/h2-3,5-10,13,19-20,26H,4,11-12,15H2,1H3,(H,27,29) ZQWMJSZYQZDARQ-UHFFFAOYSA-N 795128 US20260062420, Compound Table16.32 Dipeptidyl peptidase 1 Mus musculus 1897 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795128&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754744 528826591 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741329 C=C1Oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNC[C@H](O)CO4)cc3)cc2N1C InChI=1S/C24H26N4O4/c1-15-28(2)21-10-18(7-8-22(21)32-15)17-5-3-16(4-6-17)9-19(11-25)27-24(30)23-13-26-12-20(29)14-31-23/h3-8,10,19-20,23,26,29H,1,9,12-14H2,2H3,(H,27,30) CLWVNJLRVWWIGP-UHFFFAOYSA-N 795129 US20260062420, Compound Table16.33 Dipeptidyl peptidase 1 Homo sapiens 2.30 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795129&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423173 528826592 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741330 C=C1Oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNC[C@H](O)CO4)cc3)cc2N1C InChI=1S/C24H26N4O4/c1-15-28(2)21-10-18(7-8-22(21)32-15)17-5-3-16(4-6-17)9-19(11-25)27-24(30)23-13-26-12-20(29)14-31-23/h3-8,10,19-20,23,26,29H,1,9,12-14H2,2H3,(H,27,30) CLWVNJLRVWWIGP-UHFFFAOYSA-N 795129 US20260062420, Compound Table16.33 Dipeptidyl peptidase 1 Mus musculus 2.00 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795129&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423173 528826592 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741331 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNCC(O)C4)cc3)cc21 InChI=1S/C23H24N4O4/c1-27-20-10-16(6-7-21(20)31-23(27)30)15-4-2-14(3-5-15)8-18(11-24)26-22(29)17-9-19(28)13-25-12-17/h2-7,10,17-19,25,28H,8-9,12-13H2,1H3,(H,26,29) PWPLMUPMRVOORC-UHFFFAOYSA-N 795130 US20260062420, Compound Table16.34 Dipeptidyl peptidase 1 Homo sapiens 2027 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795130&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754672 528826593 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741332 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNCC(O)C4)cc3)cc21 InChI=1S/C23H24N4O4/c1-27-20-10-16(6-7-21(20)31-23(27)30)15-4-2-14(3-5-15)8-18(11-24)26-22(29)17-9-19(28)13-25-12-17/h2-7,10,17-19,25,28H,8-9,12-13H2,1H3,(H,26,29) PWPLMUPMRVOORC-UHFFFAOYSA-N 795130 US20260062420, Compound Table16.34 Dipeptidyl peptidase 1 Mus musculus 2174 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795130&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754672 528826593 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741333 C=C1Oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CC5NCCCC5N4)cc3)cc2N1C InChI=1S/C26H29N5O2/c1-16-31(2)24-13-19(9-10-25(24)33-16)18-7-5-17(6-8-18)12-20(15-27)29-26(32)23-14-22-21(30-23)4-3-11-28-22/h5-10,13,20-23,28,30H,1,3-4,11-12,14H2,2H3,(H,29,32) YJVRHUWIVCHFEY-UHFFFAOYSA-N 795131 US20260062420, Compound Table16.35 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795131 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795131&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754756 528826594 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741334 C=C1Oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CC5NCCCC5N4)cc3)cc2N1C InChI=1S/C26H29N5O2/c1-16-31(2)24-13-19(9-10-25(24)33-16)18-7-5-17(6-8-18)12-20(15-27)29-26(32)23-14-22-21(30-23)4-3-11-28-22/h5-10,13,20-23,28,30H,1,3-4,11-12,14H2,2H3,(H,29,32) YJVRHUWIVCHFEY-UHFFFAOYSA-N 795131 US20260062420, Compound Table16.35 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795131 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795131&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754756 528826594 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741335 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CC5OCCC5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-20-11-16(6-7-21(20)32-24(28)30)15-4-2-14(3-5-15)10-17(13-25)26-23(29)19-12-22-18(27-19)8-9-31-22/h2-7,11,17-19,22,27H,8-10,12H2,1H3,(H,26,29) JBDCUJLGAILCDA-UHFFFAOYSA-N 795132 US20260062420, Compound Table16.36 Dipeptidyl peptidase 1 Homo sapiens 784 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795132&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754198 528826595 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741336 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CC5OCCC5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-20-11-16(6-7-21(20)32-24(28)30)15-4-2-14(3-5-15)10-17(13-25)26-23(29)19-12-22-18(27-19)8-9-31-22/h2-7,11,17-19,22,27H,8-10,12H2,1H3,(H,26,29) JBDCUJLGAILCDA-UHFFFAOYSA-N 795132 US20260062420, Compound Table16.36 Dipeptidyl peptidase 1 Mus musculus 438 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795132&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754198 528826595 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741337 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)C4CC4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-20-11-17(8-9-21(20)30-23(27)29)15-4-2-14(3-5-15)10-18(13-24)26-22(28)12-19(25)16-6-7-16/h2-5,8-9,11,16,18-19H,6-7,10,12,25H2,1H3,(H,26,28) GPVTVFPWEGRTOD-UHFFFAOYSA-N 795133 US20260062420, Compound Table16.37 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795133 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795133&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754212 528826596 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741338 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)C4CC4)cc3)cc21 InChI=1S/C23H24N4O3/c1-27-20-11-17(8-9-21(20)30-23(27)29)15-4-2-14(3-5-15)10-18(13-24)26-22(28)12-19(25)16-6-7-16/h2-5,8-9,11,16,18-19H,6-7,10,12,25H2,1H3,(H,26,28) GPVTVFPWEGRTOD-UHFFFAOYSA-N 795133 US20260062420, Compound Table16.37 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795133 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795133&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754212 528826596 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741339 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCNC4)cc3)cc21 InChI=1S/C22H22N4O3/c1-26-19-11-16(6-7-20(19)29-22(26)28)15-4-2-14(3-5-15)10-18(12-23)25-21(27)17-8-9-24-13-17/h2-7,11,17-18,24H,8-10,13H2,1H3,(H,25,27) YUWNZUHEFZYUPZ-UHFFFAOYSA-N 795134 US20260062420, Compound Table16.38 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795134&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754105 528826597 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741340 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCNC4)cc3)cc21 InChI=1S/C22H22N4O3/c1-26-19-11-16(6-7-20(19)29-22(26)28)15-4-2-14(3-5-15)10-18(12-23)25-21(27)17-8-9-24-13-17/h2-7,11,17-18,24H,8-10,13H2,1H3,(H,25,27) YUWNZUHEFZYUPZ-UHFFFAOYSA-N 795134 US20260062420, Compound Table16.38 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795134&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754105 528826597 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741341 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC4(N)CCCCC4)cc3)cc21 InChI=1S/C25H28N4O3/c1-29-21-14-19(9-10-22(21)32-24(29)31)18-7-5-17(6-8-18)13-20(16-26)28-23(30)15-25(27)11-3-2-4-12-25/h5-10,14,20H,2-4,11-13,15,27H2,1H3,(H,28,30) FUMSZOCJHNVUBH-UHFFFAOYSA-N 795135 US20260062420, Compound Table16.39 Dipeptidyl peptidase 1 Homo sapiens 1100 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795135 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795135&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754114 528826598 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741342 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC4(N)CCCCC4)cc3)cc21 InChI=1S/C25H28N4O3/c1-29-21-14-19(9-10-22(21)32-24(29)31)18-7-5-17(6-8-18)13-20(16-26)28-23(30)15-25(27)11-3-2-4-12-25/h5-10,14,20H,2-4,11-13,15,27H2,1H3,(H,28,30) FUMSZOCJHNVUBH-UHFFFAOYSA-N 795135 US20260062420, Compound Table16.39 Dipeptidyl peptidase 1 Mus musculus 815 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795135 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795135&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754114 528826598 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741343 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNCC45CCC5)cc3)cc21 InChI=1S/C25H26N4O3/c1-29-21-12-18(7-8-22(21)32-24(29)31)17-5-3-16(4-6-17)11-19(13-26)28-23(30)20-14-27-15-25(20)9-2-10-25/h3-8,12,19-20,27H,2,9-11,14-15H2,1H3,(H,28,30) MMMGRUBPIUDTCU-UHFFFAOYSA-N 795136 US20260062420, Compound Table16.40 Dipeptidyl peptidase 1 Homo sapiens 828 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795136&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754651 528826599 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741344 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNCC45CCC5)cc3)cc21 InChI=1S/C25H26N4O3/c1-29-21-12-18(7-8-22(21)32-24(29)31)17-5-3-16(4-6-17)11-19(13-26)28-23(30)20-14-27-15-25(20)9-2-10-25/h3-8,12,19-20,27H,2,9-11,14-15H2,1H3,(H,28,30) MMMGRUBPIUDTCU-UHFFFAOYSA-N 795136 US20260062420, Compound Table16.40 Dipeptidyl peptidase 1 Mus musculus 2084 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795136&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754651 528826599 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741345 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4C=CCNC4)cc3)cc21 InChI=1S/C23H22N4O3/c1-27-20-12-17(8-9-21(20)30-23(27)29)16-6-4-15(5-7-16)11-19(13-24)26-22(28)18-3-2-10-25-14-18/h2-9,12,18-19,25H,10-11,14H2,1H3,(H,26,28) MCXCLZPPARFEPQ-UHFFFAOYSA-N 795137 US20260062420, Compound Table16.41 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795137&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754697 528826600 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741346 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4C=CCNC4)cc3)cc21 InChI=1S/C23H22N4O3/c1-27-20-12-17(8-9-21(20)30-23(27)29)16-6-4-15(5-7-16)11-19(13-24)26-22(28)18-3-2-10-25-14-18/h2-9,12,18-19,25H,10-11,14H2,1H3,(H,26,28) MCXCLZPPARFEPQ-UHFFFAOYSA-N 795137 US20260062420, Compound Table16.41 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795137&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754697 528826600 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741347 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@H]5OCC[C@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-20-11-16(6-7-21(20)32-24(28)30)15-4-2-14(3-5-15)10-17(13-25)26-23(29)19-12-22-18(27-19)8-9-31-22/h2-7,11,17-19,22,27H,8-10,12H2,1H3,(H,26,29) JBDCUJLGAILCDA-UHFFFAOYSA-N 795138 US20260062420, Compound Table16.42 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795138&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754285 528826601 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741348 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@H]5OCC[C@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-20-11-16(6-7-21(20)32-24(28)30)15-4-2-14(3-5-15)10-17(13-25)26-23(29)19-12-22-18(27-19)8-9-31-22/h2-7,11,17-19,22,27H,8-10,12H2,1H3,(H,26,29) JBDCUJLGAILCDA-UHFFFAOYSA-N 795138 US20260062420, Compound Table16.42 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795138&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754285 528826601 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741349 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H]4C[C@H]5OCC[C@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-20-11-16(6-7-21(20)32-24(28)30)15-4-2-14(3-5-15)10-17(13-25)26-23(29)19-12-22-18(27-19)8-9-31-22/h2-7,11,17-19,22,27H,8-10,12H2,1H3,(H,26,29) JBDCUJLGAILCDA-UHFFFAOYSA-N 795139 US20260062420, Compound Table16.43 Dipeptidyl peptidase 1 Homo sapiens 497 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795139&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754297 528826602 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741350 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H]4C[C@H]5OCC[C@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-20-11-16(6-7-21(20)32-24(28)30)15-4-2-14(3-5-15)10-17(13-25)26-23(29)19-12-22-18(27-19)8-9-31-22/h2-7,11,17-19,22,27H,8-10,12H2,1H3,(H,26,29) JBDCUJLGAILCDA-UHFFFAOYSA-N 795139 US20260062420, Compound Table16.43 Dipeptidyl peptidase 1 Mus musculus 226 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795139&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754297 528826602 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741351 CO[C@H]1CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C24H26N4O5/c1-28-20-10-17(7-8-21(20)33-24(28)30)16-5-3-15(4-6-16)9-18(11-25)27-23(29)22-13-26-12-19(31-2)14-32-22/h3-8,10,18-19,22,26H,9,12-14H2,1-2H3,(H,27,29) DNTVNLPDUPEMGE-UHFFFAOYSA-N 795140 US20260062420, Compound Table16.44 Dipeptidyl peptidase 1 Homo sapiens 745 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795140&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423174 528826603 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741352 CO[C@H]1CNC[C@@H](C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)OC1 InChI=1S/C24H26N4O5/c1-28-20-10-17(7-8-21(20)33-24(28)30)16-5-3-15(4-6-16)9-18(11-25)27-23(29)22-13-26-12-19(31-2)14-32-22/h3-8,10,18-19,22,26H,9,12-14H2,1-2H3,(H,27,29) DNTVNLPDUPEMGE-UHFFFAOYSA-N 795140 US20260062420, Compound Table16.44 Dipeptidyl peptidase 1 Mus musculus 583 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795140&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423174 528826603 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741353 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNC(C)(C)CO4)cc3)cc21 InChI=1S/C24H26N4O4/c1-24(2)14-31-21(13-26-24)22(29)27-18(12-25)10-15-4-6-16(7-5-15)17-8-9-20-19(11-17)28(3)23(30)32-20/h4-9,11,18,21,26H,10,13-14H2,1-3H3,(H,27,29) WBOPQCKSBWVASB-UHFFFAOYSA-N 795141 US20260062420, Compound Table16.45 Dipeptidyl peptidase 1 Homo sapiens 360 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795141&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754597 528826604 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741354 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNC(C)(C)CO4)cc3)cc21 InChI=1S/C24H26N4O4/c1-24(2)14-31-21(13-26-24)22(29)27-18(12-25)10-15-4-6-16(7-5-15)17-8-9-20-19(11-17)28(3)23(30)32-20/h4-9,11,18,21,26H,10,13-14H2,1-3H3,(H,27,29) WBOPQCKSBWVASB-UHFFFAOYSA-N 795141 US20260062420, Compound Table16.45 Dipeptidyl peptidase 1 Mus musculus 785 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795141&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754597 528826604 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741355 [2H]C([2H])([2H])n1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)cc3)cc21 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/i1D3 AEXFXNFMSAAELR-FIBGUPNXSA-N 795142 US20260062420, Compound Table16.46 Dipeptidyl peptidase 1 Homo sapiens 18.6 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795142&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754530 528826605 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741356 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 |r| InChI=1S/C23H23FN4O4/c1-28-19-11-15(5-6-20(19)32-23(28)30)14-3-4-16(18(24)10-14)9-17(12-25)27-22(29)21-13-26-7-2-8-31-21/h3-6,10-11,17,21,26H,2,7-9,13H2,1H3,(H,27,29) ONJDRXNRBKHINH-UHFFFAOYSA-N 633583 (S) N ((S)-1-cyano-2-(2-fluoro-4-(3-(methyl-d3)-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl) ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 23::US20260062420, Compound Table16.47 Dipeptidyl peptidase 1 Homo sapiens 6.60 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633583&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 162738687 486499297 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741357 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 |r| InChI=1S/C23H23FN4O4/c1-28-19-11-15(5-6-20(19)32-23(28)30)14-3-4-16(18(24)10-14)9-17(12-25)27-22(29)21-13-26-7-2-8-31-21/h3-6,10-11,17,21,26H,2,7-9,13H2,1H3,(H,27,29) ONJDRXNRBKHINH-UHFFFAOYSA-N 633583 (S) N ((S)-1-cyano-2-(2-fluoro-4-(3-(methyl-d3)-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl) ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 23::US20260062420, Compound Table16.47 Dipeptidyl peptidase 1 Mus musculus 8.10 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633583&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 162738687 486499297 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741358 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3CNCCCO3)c(F)c2)cc1 InChI=1S/C22H21FN4O2/c23-20-11-17(16-4-2-15(12-24)3-5-16)6-7-18(20)10-19(13-25)27-22(28)21-14-26-8-1-9-29-21/h2-7,11,19,21,26H,1,8-10,14H2,(H,27,28) BRDKOSLYLHCPSZ-UHFFFAOYSA-N 795144 US20260062420, Compound Table16.48 Dipeptidyl peptidase 1 Homo sapiens 31.4 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795144&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754164 528826607 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741359 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3CNCCCO3)c(F)c2)cc1 InChI=1S/C22H21FN4O2/c23-20-11-17(16-4-2-15(12-24)3-5-16)6-7-18(20)10-19(13-25)27-22(28)21-14-26-8-1-9-29-21/h2-7,11,19,21,26H,1,8-10,14H2,(H,27,28) BRDKOSLYLHCPSZ-UHFFFAOYSA-N 795144 US20260062420, Compound Table16.48 Dipeptidyl peptidase 1 Mus musculus 31.0 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795144&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754164 528826607 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741360 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3CNCCCO3)c(F)c2)cc1 InChI=1S/C22H21FN4O2/c23-20-11-17(16-4-2-15(12-24)3-5-16)6-7-18(20)10-19(13-25)27-22(28)21-14-26-8-1-9-29-21/h2-7,11,19,21,26H,1,8-10,14H2,(H,27,28) BRDKOSLYLHCPSZ-UHFFFAOYSA-N 795145 US20260062420, Compound Table16.49 Dipeptidyl peptidase 1 Homo sapiens 49.5 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795145&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754164 528826608 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741361 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3CNCCCO3)c(F)c2)cc1 InChI=1S/C22H21FN4O2/c23-20-11-17(16-4-2-15(12-24)3-5-16)6-7-18(20)10-19(13-25)27-22(28)21-14-26-8-1-9-29-21/h2-7,11,19,21,26H,1,8-10,14H2,(H,27,28) BRDKOSLYLHCPSZ-UHFFFAOYSA-N 795145 US20260062420, Compound Table16.49 Dipeptidyl peptidase 1 Mus musculus 36.7 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795145&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754164 528826608 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741362 [2H]C([2H])([2H])n1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)c(F)c3)cc21 InChI=1S/C23H23FN4O4/c1-28-19-11-15(5-6-20(19)32-23(28)30)14-3-4-16(18(24)10-14)9-17(12-25)27-22(29)21-13-26-7-2-8-31-21/h3-6,10-11,17,21,26H,2,7-9,13H2,1H3,(H,27,29)/i1D3 ONJDRXNRBKHINH-FIBGUPNXSA-N 795146 US20260062420, Compound Table16.50 Dipeptidyl peptidase 1 Homo sapiens 6.00 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795146&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 162738607 528826609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741363 Cn1c(=O)oc2ccc(-c3ccc(CC(C#N)NC(=O)C4CNC4)cc3)cc21 InChI=1S/C21H20N4O3/c1-25-18-9-15(6-7-19(18)28-21(25)27)14-4-2-13(3-5-14)8-17(10-22)24-20(26)16-11-23-12-16/h2-7,9,16-17,23H,8,11-12H2,1H3,(H,24,26) KKQJINBHBJVRRZ-UHFFFAOYSA-N 795147 US20260062420, Compound Table16.51 Dipeptidyl peptidase 1 Homo sapiens 1657 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795147&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754176 528826610 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741364 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3CNC3)cc2)cc1 InChI=1S/C20H18N4O/c21-10-15-3-7-17(8-4-15)16-5-1-14(2-6-16)9-19(11-22)24-20(25)18-12-23-13-18/h1-8,18-19,23H,9,12-13H2,(H,24,25) KKZSDSKZIZKIPC-UHFFFAOYSA-N 762869 (S)-N-(1-cyano-2-(4'-cyano- [1,1'-biphenyl]-4- yl)ethyl)azetidine-3- carboxamide::US20250250232, Example 9::US20260062420, Compound Table16.52 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762869&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170711272 520664324 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741365 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3CNC3)cc2)cc1 InChI=1S/C20H18N4O/c21-10-15-3-7-17(8-4-15)16-5-1-14(2-6-16)9-19(11-22)24-20(25)18-12-23-13-18/h1-8,18-19,23H,9,12-13H2,(H,24,25) KKZSDSKZIZKIPC-UHFFFAOYSA-N 762869 (S)-N-(1-cyano-2-(4'-cyano- [1,1'-biphenyl]-4- yl)ethyl)azetidine-3- carboxamide::US20250250232, Example 9::US20260062420, Compound Table16.52 Dipeptidyl peptidase 1 Mus musculus 4349 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762869&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170711272 520664324 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741366 [2H]C([2H])([2H])n1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNC4)cc3)cc21 InChI=1S/C21H20N4O3/c1-25-18-9-15(6-7-19(18)28-21(25)27)14-4-2-13(3-5-14)8-17(10-22)24-20(26)16-11-23-12-16/h2-7,9,16-17,23H,8,11-12H2,1H3,(H,24,26)/i1D3 KKQJINBHBJVRRZ-FIBGUPNXSA-N 795149 US20260062420, Compound Table16.53 Dipeptidyl peptidase 1 Homo sapiens 1506 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795149&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423175 528826612 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741367 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNC4)s3)cc21 InChI=1S/C19H18N4O3S/c1-23-15-6-11(2-4-16(15)26-19(23)25)17-5-3-14(27-17)7-13(8-20)22-18(24)12-9-21-10-12/h2-6,12-13,21H,7,9-10H2,1H3,(H,22,24) NNPQVNGJSXFWGG-UHFFFAOYSA-N 795150 US20260062420, Compound Table16.54 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795150&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754332 528826613 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741368 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNC4)s3)cc21 InChI=1S/C19H18N4O3S/c1-23-15-6-11(2-4-16(15)26-19(23)25)17-5-3-14(27-17)7-13(8-20)22-18(24)12-9-21-10-12/h2-6,12-13,21H,7,9-10H2,1H3,(H,22,24) NNPQVNGJSXFWGG-UHFFFAOYSA-N 795150 US20260062420, Compound Table16.54 Dipeptidyl peptidase 1 Mus musculus 4934 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795150&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754332 528826613 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741369 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3CNC3)s2)cc1 InChI=1S/C18H16N4OS/c19-8-12-1-3-13(4-2-12)17-6-5-16(24-17)7-15(9-20)22-18(23)14-10-21-11-14/h1-6,14-15,21H,7,10-11H2,(H,22,23) AEXIMAYOQNZXHP-UHFFFAOYSA-N 795151 US20260062420, Compound Table16.55 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795151 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795151&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754675 528826614 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741370 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3CNC3)s2)cc1 InChI=1S/C18H16N4OS/c19-8-12-1-3-13(4-2-12)17-6-5-16(24-17)7-15(9-20)22-18(23)14-10-21-11-14/h1-6,14-15,21H,7,10-11H2,(H,22,23) AEXIMAYOQNZXHP-UHFFFAOYSA-N 795151 US20260062420, Compound Table16.55 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795151 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795151&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754675 528826614 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741371 [2H]C([2H])([2H])n1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNC4)s3)cc21 InChI=1S/C19H18N4O3S/c1-23-15-6-11(2-4-16(15)26-19(23)25)17-5-3-14(27-17)7-13(8-20)22-18(24)12-9-21-10-12/h2-6,12-13,21H,7,9-10H2,1H3,(H,22,24)/i1D3 NNPQVNGJSXFWGG-FIBGUPNXSA-N 795152 US20260062420, Compound Table16.56 Dipeptidyl peptidase 1 Homo sapiens 4941 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795152 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795152&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754132 528826615 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741372 Cn1c(=O)oc2ccc(-c3ccc(CC(C#N)NC(=O)C4CNC4)c(F)c3)cc21 InChI=1S/C21H19FN4O3/c1-26-18-8-13(4-5-19(18)29-21(26)28)12-2-3-14(17(22)7-12)6-16(9-23)25-20(27)15-10-24-11-15/h2-5,7-8,15-16,24H,6,10-11H2,1H3,(H,25,27) PCXZRZHYQUGFGP-UHFFFAOYSA-N 795153 US20260062420, Compound Table16.57 Dipeptidyl peptidase 1 Homo sapiens 432 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795153 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795153&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754480 528826616 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741373 Cn1c(=O)oc2ccc(-c3ccc(CC(C#N)NC(=O)C4CNC4)c(F)c3)cc21 InChI=1S/C21H19FN4O3/c1-26-18-8-13(4-5-19(18)29-21(26)28)12-2-3-14(17(22)7-12)6-16(9-23)25-20(27)15-10-24-11-15/h2-5,7-8,15-16,24H,6,10-11H2,1H3,(H,25,27) PCXZRZHYQUGFGP-UHFFFAOYSA-N 795153 US20260062420, Compound Table16.57 Dipeptidyl peptidase 1 Mus musculus 647 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795153 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795153&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754480 528826616 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741374 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3CNC3)c(F)c2)cc1 InChI=1S/C20H17FN4O/c21-19-8-15(14-3-1-13(9-22)2-4-14)5-6-16(19)7-18(10-23)25-20(26)17-11-24-12-17/h1-6,8,17-18,24H,7,11-12H2,(H,25,26) UXIKLQLFQCMFEP-UHFFFAOYSA-N 795154 US20260062420, Compound Table16.58 Dipeptidyl peptidase 1 Homo sapiens 1564 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795154 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795154&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754147 528826617 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741375 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3CNC3)c(F)c2)cc1 InChI=1S/C20H17FN4O/c21-19-8-15(14-3-1-13(9-22)2-4-14)5-6-16(19)7-18(10-23)25-20(26)17-11-24-12-17/h1-6,8,17-18,24H,7,11-12H2,(H,25,26) UXIKLQLFQCMFEP-UHFFFAOYSA-N 795154 US20260062420, Compound Table16.58 Dipeptidyl peptidase 1 Mus musculus 1847 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795154 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795154&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754147 528826617 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741376 [2H]C([2H])([2H])n1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNC4)c(F)c3)cc21 InChI=1S/C21H19FN4O3/c1-26-18-8-13(4-5-19(18)29-21(26)28)12-2-3-14(17(22)7-12)6-16(9-23)25-20(27)15-10-24-11-15/h2-5,7-8,15-16,24H,6,10-11H2,1H3,(H,25,27)/i1D3 PCXZRZHYQUGFGP-FIBGUPNXSA-N 795155 US20260062420, Compound Table16.59 Dipeptidyl peptidase 1 Homo sapiens 416 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795155 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795155&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754434 528826618 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741377 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5COC[C@@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-21-10-16(6-7-22(21)32-24(28)30)15-4-2-14(3-5-15)8-18(11-25)26-23(29)19-9-17-12-31-13-20(17)27-19/h2-7,10,17-20,27H,8-9,12-13H2,1H3,(H,26,29) NXIQEAQUOGZJGG-UHFFFAOYSA-N 795156 US20260062420, Compound Table16.60 Dipeptidyl peptidase 1 Homo sapiens 311 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795156 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795156&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754199 528826619 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741378 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5COC[C@@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-21-10-16(6-7-22(21)32-24(28)30)15-4-2-14(3-5-15)8-18(11-25)26-23(29)19-9-17-12-31-13-20(17)27-19/h2-7,10,17-20,27H,8-9,12-13H2,1H3,(H,26,29) NXIQEAQUOGZJGG-UHFFFAOYSA-N 795156 US20260062420, Compound Table16.60 Dipeptidyl peptidase 1 Mus musculus 136 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795156 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795156&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754199 528826619 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741379 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@@H]4COC[C@@H]4N3)cc2)cc1 InChI=1S/C23H22N4O2/c24-11-16-3-7-18(8-4-16)17-5-1-15(2-6-17)9-20(12-25)26-23(28)21-10-19-13-29-14-22(19)27-21/h1-8,19-22,27H,9-10,13-14H2,(H,26,28) BVVHXTPPMMDWNC-UHFFFAOYSA-N 795157 US20260062420, Compound Table16.61 Dipeptidyl peptidase 1 Homo sapiens 480 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795157 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795157&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754280 528826620 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741380 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@@H]4COC[C@@H]4N3)cc2)cc1 InChI=1S/C23H22N4O2/c24-11-16-3-7-18(8-4-16)17-5-1-15(2-6-17)9-20(12-25)26-23(28)21-10-19-13-29-14-22(19)27-21/h1-8,19-22,27H,9-10,13-14H2,(H,26,28) BVVHXTPPMMDWNC-UHFFFAOYSA-N 795157 US20260062420, Compound Table16.61 Dipeptidyl peptidase 1 Mus musculus 246 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795157 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795157&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754280 528826620 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741381 [2H]C([2H])([2H])n1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5COC[C@@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-21-10-16(6-7-22(21)32-24(28)30)15-4-2-14(3-5-15)8-18(11-25)26-23(29)19-9-17-12-31-13-20(17)27-19/h2-7,10,17-20,27H,8-9,12-13H2,1H3,(H,26,29)/i1D3 NXIQEAQUOGZJGG-FIBGUPNXSA-N 795158 US20260062420, Compound Table16.62 Dipeptidyl peptidase 1 Homo sapiens 426 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795158 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795158&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754596 528826621 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741382 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5COC[C@@H]5N4)s3)cc21 InChI=1S/C22H22N4O4S/c1-26-18-7-12(2-4-19(18)30-22(26)28)20-5-3-15(31-20)8-14(9-23)24-21(27)16-6-13-10-29-11-17(13)25-16/h2-5,7,13-14,16-17,25H,6,8,10-11H2,1H3,(H,24,27) AMCZKBAFLXRAJS-UHFFFAOYSA-N 795159 US20260062420, Compound Table16.63 Dipeptidyl peptidase 1 Homo sapiens 589 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795159&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754508 528826622 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741383 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5COC[C@@H]5N4)s3)cc21 InChI=1S/C22H22N4O4S/c1-26-18-7-12(2-4-19(18)30-22(26)28)20-5-3-15(31-20)8-14(9-23)24-21(27)16-6-13-10-29-11-17(13)25-16/h2-5,7,13-14,16-17,25H,6,8,10-11H2,1H3,(H,24,27) AMCZKBAFLXRAJS-UHFFFAOYSA-N 795159 US20260062420, Compound Table16.63 Dipeptidyl peptidase 1 Mus musculus 247 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795159&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754508 528826622 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741384 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@@H]4COC[C@@H]4N3)s2)cc1 InChI=1S/C21H20N4O2S/c22-9-13-1-3-14(4-2-13)20-6-5-17(28-20)8-16(10-23)24-21(26)18-7-15-11-27-12-19(15)25-18/h1-6,15-16,18-19,25H,7-8,11-12H2,(H,24,26) BOJASERIBYIDEY-UHFFFAOYSA-N 795160 US20260062420, Compound Table16.64 Dipeptidyl peptidase 1 Homo sapiens 2270 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795160 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795160&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754633 528826623 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741385 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@@H]4COC[C@@H]4N3)s2)cc1 InChI=1S/C21H20N4O2S/c22-9-13-1-3-14(4-2-13)20-6-5-17(28-20)8-16(10-23)24-21(26)18-7-15-11-27-12-19(15)25-18/h1-6,15-16,18-19,25H,7-8,11-12H2,(H,24,26) BOJASERIBYIDEY-UHFFFAOYSA-N 795160 US20260062420, Compound Table16.64 Dipeptidyl peptidase 1 Mus musculus 366 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795160 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795160&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754633 528826623 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741386 [2H]C([2H])([2H])n1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5COC[C@@H]5N4)s3)cc21 InChI=1S/C22H22N4O4S/c1-26-18-7-12(2-4-19(18)30-22(26)28)20-5-3-15(31-20)8-14(9-23)24-21(27)16-6-13-10-29-11-17(13)25-16/h2-5,7,13-14,16-17,25H,6,8,10-11H2,1H3,(H,24,27)/i1D3 AMCZKBAFLXRAJS-FIBGUPNXSA-N 795161 US20260062420, Compound Table16.65 Dipeptidyl peptidase 1 Homo sapiens 664 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795161 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795161&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754510 528826624 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741387 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5COC[C@@H]5N4)c(F)c3)cc21 InChI=1S/C24H23FN4O4/c1-29-21-9-14(4-5-22(21)33-24(29)31)13-2-3-15(18(25)7-13)6-17(10-26)27-23(30)19-8-16-11-32-12-20(16)28-19/h2-5,7,9,16-17,19-20,28H,6,8,11-12H2,1H3,(H,27,30) NMIMDHSVZNYZIY-UHFFFAOYSA-N 795162 US20260062420, Compound Table16.66 Dipeptidyl peptidase 1 Homo sapiens 179 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795162 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795162&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754485 528826625 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741388 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5COC[C@@H]5N4)c(F)c3)cc21 InChI=1S/C24H23FN4O4/c1-29-21-9-14(4-5-22(21)33-24(29)31)13-2-3-15(18(25)7-13)6-17(10-26)27-23(30)19-8-16-11-32-12-20(16)28-19/h2-5,7,9,16-17,19-20,28H,6,8,11-12H2,1H3,(H,27,30) NMIMDHSVZNYZIY-UHFFFAOYSA-N 795162 US20260062420, Compound Table16.66 Dipeptidyl peptidase 1 Mus musculus 41.2 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795162 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795162&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754485 528826625 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741389 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@@H]4COC[C@@H]4N3)c(F)c2)cc1 InChI=1S/C23H21FN4O2/c24-20-8-16(15-3-1-14(10-25)2-4-15)5-6-17(20)7-19(11-26)27-23(29)21-9-18-12-30-13-22(18)28-21/h1-6,8,18-19,21-22,28H,7,9,12-13H2,(H,27,29) DJDXCGWLZGBUJB-UHFFFAOYSA-N 795163 US20260062420, Compound Table16.67 Dipeptidyl peptidase 1 Homo sapiens 526 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795163 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795163&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754500 528826626 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741390 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@@H]4COC[C@@H]4N3)c(F)c2)cc1 InChI=1S/C23H21FN4O2/c24-20-8-16(15-3-1-14(10-25)2-4-15)5-6-17(20)7-19(11-26)27-23(29)21-9-18-12-30-13-22(18)28-21/h1-6,8,18-19,21-22,28H,7,9,12-13H2,(H,27,29) DJDXCGWLZGBUJB-UHFFFAOYSA-N 795163 US20260062420, Compound Table16.67 Dipeptidyl peptidase 1 Mus musculus 107 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795163 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795163&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754500 528826626 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741391 [2H]C([2H])([2H])n1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5COC[C@@H]5N4)c(F)c3)cc21 InChI=1S/C24H23FN4O4/c1-29-21-9-14(4-5-22(21)33-24(29)31)13-2-3-15(18(25)7-13)6-17(10-26)27-23(30)19-8-16-11-32-12-20(16)28-19/h2-5,7,9,16-17,19-20,28H,6,8,11-12H2,1H3,(H,27,30)/i1D3 NMIMDHSVZNYZIY-FIBGUPNXSA-N 795164 US20260062420, Compound Table16.68 Dipeptidyl peptidase 1 Homo sapiens 102 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795164 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795164&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754545 528826627 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741392 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)cc3F)cc21 InChI=1S/C23H23FN4O4/c1-28-19-11-15(4-6-20(19)32-23(28)30)17-5-3-14(10-18(17)24)9-16(12-25)27-22(29)21-13-26-7-2-8-31-21/h3-6,10-11,16,21,26H,2,7-9,13H2,1H3,(H,27,29) XYRFLTHEWFURFL-UHFFFAOYSA-N 795165 US20260062420, Compound Table16.69 Dipeptidyl peptidase 1 Homo sapiens 186 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795165 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795165&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 162738700 528826628 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741393 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)cc3F)cc21 InChI=1S/C23H23FN4O4/c1-28-19-11-15(4-6-20(19)32-23(28)30)17-5-3-14(10-18(17)24)9-16(12-25)27-22(29)21-13-26-7-2-8-31-21/h3-6,10-11,16,21,26H,2,7-9,13H2,1H3,(H,27,29) XYRFLTHEWFURFL-UHFFFAOYSA-N 795165 US20260062420, Compound Table16.69 Dipeptidyl peptidase 1 Mus musculus 218 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795165 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795165&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 162738700 528826628 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741394 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCCCC4)cc3)cc21 InChI=1S/C24H25N3O3/c1-27-21-14-19(11-12-22(21)30-24(27)29)17-9-7-16(8-10-17)13-20(15-25)26-23(28)18-5-3-2-4-6-18/h7-12,14,18,20H,2-6,13H2,1H3,(H,26,28) XNRRARDYXIUQDV-UHFFFAOYSA-N 795166 US20260062420, Compound Table16.70 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795166 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795166&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754468 528826629 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741395 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CCCCC4)cc3)cc21 InChI=1S/C24H25N3O3/c1-27-21-14-19(11-12-22(21)30-24(27)29)17-9-7-16(8-10-17)13-20(15-25)26-23(28)18-5-3-2-4-6-18/h7-12,14,18,20H,2-6,13H2,1H3,(H,26,28) XNRRARDYXIUQDV-UHFFFAOYSA-N 795166 US20260062420, Compound Table16.70 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795166 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795166&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754468 528826629 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741396 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@@H]4CCC[C@@H]4N3)c(F)c2)cc1 InChI=1S/C24H23FN4O/c25-21-11-17(16-6-4-15(13-26)5-7-16)8-9-18(21)10-20(14-27)28-24(30)23-12-19-2-1-3-22(19)29-23/h4-9,11,19-20,22-23,29H,1-3,10,12H2,(H,28,30) ZOXMBNLYLFBGMW-UHFFFAOYSA-N 795167 US20260062420, Compound Table16.71 Dipeptidyl peptidase 1 Homo sapiens 10.1 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795167 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795167&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754568 528826630 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741397 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3C[C@@H]4CCC[C@@H]4N3)c(F)c2)cc1 InChI=1S/C24H23FN4O/c25-21-11-17(16-6-4-15(13-26)5-7-16)8-9-18(21)10-20(14-27)28-24(30)23-12-19-2-1-3-22(19)29-23/h4-9,11,19-20,22-23,29H,1-3,10,12H2,(H,28,30) ZOXMBNLYLFBGMW-UHFFFAOYSA-N 795167 US20260062420, Compound Table16.71 Dipeptidyl peptidase 1 Mus musculus 6.50 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795167 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795167&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754568 528826630 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741398 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5CCC[C@@H]5N4)c(F)c3)cc21 InChI=1S/C25H25FN4O3/c1-30-22-12-15(7-8-23(22)33-25(30)32)14-5-6-16(19(26)10-14)9-18(13-27)28-24(31)21-11-17-3-2-4-20(17)29-21/h5-8,10,12,17-18,20-21,29H,2-4,9,11H2,1H3,(H,28,31) CVTQYELMHOZUAQ-UHFFFAOYSA-N 795168 US20260062420, Compound Table16.72 Dipeptidyl peptidase 1 Homo sapiens 5.90 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795168 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795168&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754606 528826631 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741399 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5CCC[C@@H]5N4)c(F)c3)cc21 InChI=1S/C25H25FN4O3/c1-30-22-12-15(7-8-23(22)33-25(30)32)14-5-6-16(19(26)10-14)9-18(13-27)28-24(31)21-11-17-3-2-4-20(17)29-21/h5-8,10,12,17-18,20-21,29H,2-4,9,11H2,1H3,(H,28,31) CVTQYELMHOZUAQ-UHFFFAOYSA-N 795168 US20260062420, Compound Table16.72 Dipeptidyl peptidase 1 Mus musculus 3.40 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795168 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795168&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754606 528826631 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741400 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5CCC[C@@H]5N4)cc3)cc21 InChI=1S/C25H26N4O3/c1-29-22-13-17(9-10-23(22)32-25(29)31)16-7-5-15(6-8-16)11-19(14-26)27-24(30)21-12-18-3-2-4-20(18)28-21/h5-10,13,18-21,28H,2-4,11-12H2,1H3,(H,27,30) JHTHRKJVOODGFH-UHFFFAOYSA-N 795169 US20260062420, Compound Table16.73 Dipeptidyl peptidase 1 Homo sapiens 17.3 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795169 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795169&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754649 528826632 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741401 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5CCC[C@@H]5N4)cc3)cc21 InChI=1S/C25H26N4O3/c1-29-22-13-17(9-10-23(22)32-25(29)31)16-7-5-15(6-8-16)11-19(14-26)27-24(30)21-12-18-3-2-4-20(18)28-21/h5-10,13,18-21,28H,2-4,11-12H2,1H3,(H,27,30) JHTHRKJVOODGFH-UHFFFAOYSA-N 795169 US20260062420, Compound Table16.73 Dipeptidyl peptidase 1 Mus musculus 8.20 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795169 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795169&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754649 528826632 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741402 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H]4C[C@@H]5COC[C@@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-21-10-16(6-7-22(21)32-24(28)30)15-4-2-14(3-5-15)8-18(11-25)26-23(29)19-9-17-12-31-13-20(17)27-19/h2-7,10,17-20,27H,8-9,12-13H2,1H3,(H,26,29) NXIQEAQUOGZJGG-UHFFFAOYSA-N 795170 US20260062420, Compound Table16.74 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795170 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795170&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754294 528826633 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741403 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H]4C[C@@H]5COC[C@@H]5N4)cc3)cc21 InChI=1S/C24H24N4O4/c1-28-21-10-16(6-7-22(21)32-24(28)30)15-4-2-14(3-5-15)8-18(11-25)26-23(29)19-9-17-12-31-13-20(17)27-19/h2-7,10,17-20,27H,8-9,12-13H2,1H3,(H,26,29) NXIQEAQUOGZJGG-UHFFFAOYSA-N 795170 US20260062420, Compound Table16.74 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795170 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795170&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754294 528826633 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741404 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@H]3C[C@@H]4COC[C@@H]4N3)cc2)cc1 InChI=1S/C23H22N4O2/c24-11-16-3-7-18(8-4-16)17-5-1-15(2-6-17)9-20(12-25)26-23(28)21-10-19-13-29-14-22(19)27-21/h1-8,19-22,27H,9-10,13-14H2,(H,26,28) BVVHXTPPMMDWNC-UHFFFAOYSA-N 795171 US20260062420, Compound Table16.75 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795171 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795171&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 174322580 528826634 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741405 N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@H]3C[C@@H]4COC[C@@H]4N3)cc2)cc1 InChI=1S/C23H22N4O2/c24-11-16-3-7-18(8-4-16)17-5-1-15(2-6-17)9-20(12-25)26-23(28)21-10-19-13-29-14-22(19)27-21/h1-8,19-22,27H,9-10,13-14H2,(H,26,28) BVVHXTPPMMDWNC-UHFFFAOYSA-N 795171 US20260062420, Compound Table16.75 Dipeptidyl peptidase 1 Mus musculus >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795171 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795171&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 174322580 528826634 1 MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL Dipeptidyl peptidase 1 CATC_MOUSE P97821 O08853 741406 Cn1c(=O)oc2ccc(-c3cc(F)c(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)cc3F)cc21 InChI=1S/C23H22F2N4O4/c1-29-19-9-13(3-4-20(19)33-23(29)31)16-10-17(24)14(8-18(16)25)7-15(11-26)28-22(30)21-12-27-5-2-6-32-21/h3-4,8-10,15,21,27H,2,5-7,12H2,1H3,(H,28,30) IVWHQRLJECFKHI-UHFFFAOYSA-N 795172 US20260062420, Compound Table16.76 Dipeptidyl peptidase 1 Homo sapiens 29.6 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795172&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423176 528826635 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741407 Cn1c(=O)oc2ccc(-c3cc(F)c(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)c(F)c3)cc21 InChI=1S/C23H22F2N4O4/c1-29-19-9-13(3-4-20(19)33-23(29)31)14-7-17(24)16(18(25)8-14)10-15(11-26)28-22(30)21-12-27-5-2-6-32-21/h3-4,7-9,15,21,27H,2,5-6,10,12H2,1H3,(H,28,30) PSMOJAUBJGFRJL-UHFFFAOYSA-N 795173 US20260062420, Compound Table16.77 Dipeptidyl peptidase 1 Homo sapiens 42.2 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795173 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795173&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423177 528826636 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741408 N#C[C@H](Cc1ccc(-c2ccc3c(c2)C(=O)NC3)cc1)NC(=O)[C@@H]1CNCCCO1 InChI=1S/C23H24N4O3/c24-12-19(27-23(29)21-14-25-8-1-9-30-21)10-15-2-4-16(5-3-15)17-6-7-18-13-26-22(28)20(18)11-17/h2-7,11,19,21,25H,1,8-10,13-14H2,(H,26,28)(H,27,29) PQUIGSWJNFLBEI-UHFFFAOYSA-N 795174 US20260062420, Compound Table16.78 Dipeptidyl peptidase 1 Homo sapiens 428 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795174&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 177911253 528826637 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741409 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4C[C@@H]5CCC[C@@H]5N4)c(F)c3)cc21 InChI=1S/C25H25FN4O3/c1-30-22-12-15(7-8-23(22)33-25(30)32)14-5-6-16(19(26)10-14)9-18(13-27)28-24(31)21-11-17-3-2-4-20(17)29-21/h5-8,10,12,17-18,20-21,29H,2-4,9,11H2,1H3,(H,28,31) CVTQYELMHOZUAQ-UHFFFAOYSA-N 795175 US20260062420, Compound Table16.79 Dipeptidyl peptidase 1 Homo sapiens 7.60 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795175 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795175&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754606 528826638 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741410 C=C1Oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC4(N)CCCS(=O)(=O)C4)cc3)cc2N1C InChI=1S/C25H28N4O4S/c1-17-29(2)22-13-20(8-9-23(22)33-17)19-6-4-18(5-7-19)12-21(15-26)28-24(30)14-25(27)10-3-11-34(31,32)16-25/h4-9,13,21H,1,3,10-12,14,16,27H2,2H3,(H,28,30) OSIJSKJQRKUENT-UHFFFAOYSA-N 795176 US20260062420, Compound Table16.80 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795176 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795176&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 178423178 528826639 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741411 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4CNCC45CCC5)cc3)cc21 InChI=1S/C25H26N4O3/c1-29-21-12-18(7-8-22(21)32-24(29)31)17-5-3-16(4-6-17)11-19(13-26)28-23(30)20-14-27-15-25(20)9-2-10-25/h3-8,12,19-20,27H,2,9-11,14-15H2,1H3,(H,28,30) MMMGRUBPIUDTCU-UHFFFAOYSA-N 795177 US20260062420, Compound Table16.81 Dipeptidyl peptidase 1 Homo sapiens 1217 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795177&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754651 528826640 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741412 C[C@@H]1NCCC[C@@H]1C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1 InChI=1S/C24H26N4O3/c1-15-20(4-3-11-26-15)23(29)27-19(14-25)12-16-5-7-17(8-6-16)18-9-10-22-21(13-18)28(2)24(30)31-22/h5-10,13,15,19-20,26H,3-4,11-12H2,1-2H3,(H,27,29) OQJQTPQTPSWZHY-UHFFFAOYSA-N 795178 US20260062420, Compound Table16.82 Dipeptidyl peptidase 1 Homo sapiens 1324 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795178 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795178&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754636 528826641 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741413 C[C@H]1NCCC[C@H]1C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1 InChI=1S/C24H26N4O3/c1-15-20(4-3-11-26-15)23(29)27-19(14-25)12-16-5-7-17(8-6-16)18-9-10-22-21(13-18)28(2)24(30)31-22/h5-10,13,15,19-20,26H,3-4,11-12H2,1-2H3,(H,27,29) OQJQTPQTPSWZHY-UHFFFAOYSA-N 795179 US20260062420, Compound Table16.83 Dipeptidyl peptidase 1 Homo sapiens 4475 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795179&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754279 528826642 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741414 Cn1c(=O)oc2ccc(-c3ccc(CC(C#N)NC(=O)[C@@]4(C)CNCCO4)cc3)cc21 InChI=1S/C23H24N4O4/c1-23(14-25-9-10-30-23)21(28)26-18(13-24)11-15-3-5-16(6-4-15)17-7-8-20-19(12-17)27(2)22(29)31-20/h3-8,12,18,25H,9-11,14H2,1-2H3,(H,26,28) ZEVDMDLBRAVQAU-UHFFFAOYSA-N 795180 US20260062420, Compound Table16.84 Dipeptidyl peptidase 1 Homo sapiens 1040 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795180&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754225 528826643 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 741415 Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@]4(C)CNCCO4)cc3)cc21 InChI=1S/C23H24N4O4/c1-23(14-25-9-10-30-23)21(28)26-18(13-24)11-15-3-5-16(6-4-15)17-7-8-20-19(12-17)27(2)22(29)31-20/h3-8,12,18,25H,9-11,14H2,1-2H3,(H,26,28) ZEVDMDLBRAVQAU-UHFFFAOYSA-N 795181 US20260062420, Compound Table16.85 Dipeptidyl peptidase 1 Homo sapiens >5000 US Patent 10.7270/Q2NG4WMP aid1798225 US20260062420 PLAUNT, AJ; CIPOLLA, DC; CERDAN, A; CIAPETTI, P; GOEGAN, B; AUGERI, DJ 3/5/2026 7/15/2026 Insmed http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795181&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 170754730 528826644 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8