BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 741416 COc1cc(F)ccc1-c1cc(NC(=O)C2CCCC(NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795096 US12570607, Example 3 Cyclin-dependent kinase 1 Homo sapiens 262 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795096&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492015 528826559 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741417 COc1cc(F)ccc1-c1cc(NC(=O)C2CCCC(NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795096 US12570607, Example 3 Cyclin-dependent kinase 2 Homo sapiens 2125 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795096&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492015 528826559 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741418 COc1cc(F)ccc1-c1cc(NC(=O)C2CCCC(NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795096 US12570607, Example 3 Cyclin-dependent kinase 4 Homo sapiens 1073 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795096&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492015 528826559 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741419 COc1cc(F)ccc1-c1cc(NC(=O)C2CCCC(NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795096 US12570607, Example 3 Cyclin-dependent kinase 5 Homo sapiens 721 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795096&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492015 528826559 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741420 COc1cc(F)ccc1-c1cc(NC(=O)C2CCCC(NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795096 US12570607, Example 3 Cyclin-dependent kinase 6 Homo sapiens 1386 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795096&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492015 528826559 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741421 COc1cc(F)ccc1-c1cc(NC(=O)C2CCCC(NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795096 US12570607, Example 3 Cyclin-dependent kinase 7 Homo sapiens 6206 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795096&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492015 528826559 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741422 COc1cc(F)ccc1-c1cc(NC(=O)C2CCCC(NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795096 US12570607, Example 3 Cyclin-dependent kinase 9 Homo sapiens 16.8 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795096&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492015 528826559 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741423 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795097 US12570607, Example 5 Cyclin-dependent kinase 1 Homo sapiens 125 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795097&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156491971 528826560 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741424 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795097 US12570607, Example 5 Cyclin-dependent kinase 2 Homo sapiens 475 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795097&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156491971 528826560 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741425 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795097 US12570607, Example 5 Cyclin-dependent kinase 4 Homo sapiens 429 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795097&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156491971 528826560 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741426 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795097 US12570607, Example 5 Cyclin-dependent kinase 5 Homo sapiens 452 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795097&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156491971 528826560 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741427 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795097 US12570607, Example 5 Cyclin-dependent kinase 6 Homo sapiens 1123 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795097&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156491971 528826560 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741428 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795097 US12570607, Example 5 Cyclin-dependent kinase 7 Homo sapiens 2748 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795097&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156491971 528826560 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741429 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23F2N3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) KJXMUOQPSXQJNY-UHFFFAOYSA-N 795097 US12570607, Example 5 Cyclin-dependent kinase 9 Homo sapiens 7.90 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795097&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156491971 528826560 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741430 CCOc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C22H25F2N3O3/c1-3-30-20-10-15(23)7-8-17(20)18-11-21(25-12-19(18)24)27-22(29)14-5-4-6-16(9-14)26-13(2)28/h7-8,10-12,14,16H,3-6,9H2,1-2H3,(H,26,28)(H,25,27,29) ABXSZLVIFKZCBK-UHFFFAOYSA-N 795143 US12570607, Example 7 Cyclin-dependent kinase 1 Homo sapiens 225 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795143&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156491975 528826606 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741431 CCOc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C22H25F2N3O3/c1-3-30-20-10-15(23)7-8-17(20)18-11-21(25-12-19(18)24)27-22(29)14-5-4-6-16(9-14)26-13(2)28/h7-8,10-12,14,16H,3-6,9H2,1-2H3,(H,26,28)(H,25,27,29) ABXSZLVIFKZCBK-UHFFFAOYSA-N 795143 US12570607, Example 7 Cyclin-dependent kinase 2 Homo sapiens 1051 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795143&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156491975 528826606 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741432 CCOc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C22H25F2N3O3/c1-3-30-20-10-15(23)7-8-17(20)18-11-21(25-12-19(18)24)27-22(29)14-5-4-6-16(9-14)26-13(2)28/h7-8,10-12,14,16H,3-6,9H2,1-2H3,(H,26,28)(H,25,27,29) ABXSZLVIFKZCBK-UHFFFAOYSA-N 795143 US12570607, Example 7 Cyclin-dependent kinase 4 Homo sapiens 577 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795143&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156491975 528826606 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741433 CCOc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C22H25F2N3O3/c1-3-30-20-10-15(23)7-8-17(20)18-11-21(25-12-19(18)24)27-22(29)14-5-4-6-16(9-14)26-13(2)28/h7-8,10-12,14,16H,3-6,9H2,1-2H3,(H,26,28)(H,25,27,29) ABXSZLVIFKZCBK-UHFFFAOYSA-N 795143 US12570607, Example 7 Cyclin-dependent kinase 5 Homo sapiens 910 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795143&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156491975 528826606 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741434 CCOc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C22H25F2N3O3/c1-3-30-20-10-15(23)7-8-17(20)18-11-21(25-12-19(18)24)27-22(29)14-5-4-6-16(9-14)26-13(2)28/h7-8,10-12,14,16H,3-6,9H2,1-2H3,(H,26,28)(H,25,27,29) ABXSZLVIFKZCBK-UHFFFAOYSA-N 795143 US12570607, Example 7 Cyclin-dependent kinase 6 Homo sapiens 2357 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795143&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156491975 528826606 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741435 CCOc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C22H25F2N3O3/c1-3-30-20-10-15(23)7-8-17(20)18-11-21(25-12-19(18)24)27-22(29)14-5-4-6-16(9-14)26-13(2)28/h7-8,10-12,14,16H,3-6,9H2,1-2H3,(H,26,28)(H,25,27,29) ABXSZLVIFKZCBK-UHFFFAOYSA-N 795143 US12570607, Example 7 Cyclin-dependent kinase 7 Homo sapiens 6436 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795143&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156491975 528826606 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741436 CCOc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C22H25F2N3O3/c1-3-30-20-10-15(23)7-8-17(20)18-11-21(25-12-19(18)24)27-22(29)14-5-4-6-16(9-14)26-13(2)28/h7-8,10-12,14,16H,3-6,9H2,1-2H3,(H,26,28)(H,25,27,29) ABXSZLVIFKZCBK-UHFFFAOYSA-N 795143 US12570607, Example 7 Cyclin-dependent kinase 9 Homo sapiens 7.15 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795143&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156491975 528826606 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741437 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC(C)C)c(F)cn2)C1 InChI=1S/C23H27F2N3O3/c1-13(2)31-21-10-16(24)7-8-18(21)19-11-22(26-12-20(19)25)28-23(30)15-5-4-6-17(9-15)27-14(3)29/h7-8,10-13,15,17H,4-6,9H2,1-3H3,(H,27,29)(H,26,28,30) MIBOCEDBYKMVAA-UHFFFAOYSA-N 795148 US12570607, Example 8 Cyclin-dependent kinase 1 Homo sapiens 214 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795148&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492005 528826611 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741438 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC(C)C)c(F)cn2)C1 InChI=1S/C23H27F2N3O3/c1-13(2)31-21-10-16(24)7-8-18(21)19-11-22(26-12-20(19)25)28-23(30)15-5-4-6-17(9-15)27-14(3)29/h7-8,10-13,15,17H,4-6,9H2,1-3H3,(H,27,29)(H,26,28,30) MIBOCEDBYKMVAA-UHFFFAOYSA-N 795148 US12570607, Example 8 Cyclin-dependent kinase 2 Homo sapiens 991 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795148&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492005 528826611 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741439 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC(C)C)c(F)cn2)C1 InChI=1S/C23H27F2N3O3/c1-13(2)31-21-10-16(24)7-8-18(21)19-11-22(26-12-20(19)25)28-23(30)15-5-4-6-17(9-15)27-14(3)29/h7-8,10-13,15,17H,4-6,9H2,1-3H3,(H,27,29)(H,26,28,30) MIBOCEDBYKMVAA-UHFFFAOYSA-N 795148 US12570607, Example 8 Cyclin-dependent kinase 4 Homo sapiens 273 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795148&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492005 528826611 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741440 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC(C)C)c(F)cn2)C1 InChI=1S/C23H27F2N3O3/c1-13(2)31-21-10-16(24)7-8-18(21)19-11-22(26-12-20(19)25)28-23(30)15-5-4-6-17(9-15)27-14(3)29/h7-8,10-13,15,17H,4-6,9H2,1-3H3,(H,27,29)(H,26,28,30) MIBOCEDBYKMVAA-UHFFFAOYSA-N 795148 US12570607, Example 8 Cyclin-dependent kinase 5 Homo sapiens 614 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795148&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492005 528826611 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741441 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC(C)C)c(F)cn2)C1 InChI=1S/C23H27F2N3O3/c1-13(2)31-21-10-16(24)7-8-18(21)19-11-22(26-12-20(19)25)28-23(30)15-5-4-6-17(9-15)27-14(3)29/h7-8,10-13,15,17H,4-6,9H2,1-3H3,(H,27,29)(H,26,28,30) MIBOCEDBYKMVAA-UHFFFAOYSA-N 795148 US12570607, Example 8 Cyclin-dependent kinase 6 Homo sapiens 1773 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795148&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492005 528826611 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741442 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC(C)C)c(F)cn2)C1 InChI=1S/C23H27F2N3O3/c1-13(2)31-21-10-16(24)7-8-18(21)19-11-22(26-12-20(19)25)28-23(30)15-5-4-6-17(9-15)27-14(3)29/h7-8,10-13,15,17H,4-6,9H2,1-3H3,(H,27,29)(H,26,28,30) MIBOCEDBYKMVAA-UHFFFAOYSA-N 795148 US12570607, Example 8 Cyclin-dependent kinase 7 Homo sapiens >9901 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795148&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492005 528826611 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741443 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC(C)C)c(F)cn2)C1 InChI=1S/C23H27F2N3O3/c1-13(2)31-21-10-16(24)7-8-18(21)19-11-22(26-12-20(19)25)28-23(30)15-5-4-6-17(9-15)27-14(3)29/h7-8,10-13,15,17H,4-6,9H2,1-3H3,(H,27,29)(H,26,28,30) MIBOCEDBYKMVAA-UHFFFAOYSA-N 795148 US12570607, Example 8 Cyclin-dependent kinase 9 Homo sapiens 7.21 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795148&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492005 528826611 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741444 COc1cc(Cl)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23ClFN3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) ZAFZYKFWKAPQQK-UHFFFAOYSA-N 795182 US12570607, Example 12 Cyclin-dependent kinase 1 Homo sapiens 152 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795182&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492011 528826645 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741445 COc1cc(Cl)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23ClFN3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) ZAFZYKFWKAPQQK-UHFFFAOYSA-N 795182 US12570607, Example 12 Cyclin-dependent kinase 2 Homo sapiens 533 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795182&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492011 528826645 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741446 COc1cc(Cl)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23ClFN3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) ZAFZYKFWKAPQQK-UHFFFAOYSA-N 795182 US12570607, Example 12 Cyclin-dependent kinase 4 Homo sapiens 585 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795182&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492011 528826645 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741447 COc1cc(Cl)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23ClFN3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) ZAFZYKFWKAPQQK-UHFFFAOYSA-N 795182 US12570607, Example 12 Cyclin-dependent kinase 5 Homo sapiens 297 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795182&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492011 528826645 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741448 COc1cc(Cl)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23ClFN3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) ZAFZYKFWKAPQQK-UHFFFAOYSA-N 795182 US12570607, Example 12 Cyclin-dependent kinase 6 Homo sapiens 2743 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795182&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492011 528826645 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741449 COc1cc(Cl)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23ClFN3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) ZAFZYKFWKAPQQK-UHFFFAOYSA-N 795182 US12570607, Example 12 Cyclin-dependent kinase 7 Homo sapiens >9901 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795182&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492011 528826645 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741450 COc1cc(Cl)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H23ClFN3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(23)11-24-20)16-7-6-14(22)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28) ZAFZYKFWKAPQQK-UHFFFAOYSA-N 795182 US12570607, Example 12 Cyclin-dependent kinase 9 Homo sapiens 7.44 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795182&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492011 528826645 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741451 COc1ccccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H24FN3O3/c1-13(26)24-15-7-5-6-14(10-15)21(27)25-20-11-17(18(22)12-23-20)16-8-3-4-9-19(16)28-2/h3-4,8-9,11-12,14-15H,5-7,10H2,1-2H3,(H,24,26)(H,23,25,27) VDXWHBPYYAUMKG-UHFFFAOYSA-N 795183 US12570607, Example 17 Cyclin-dependent kinase 1 Homo sapiens 193 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795183&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492008 528826646 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741452 COc1ccccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H24FN3O3/c1-13(26)24-15-7-5-6-14(10-15)21(27)25-20-11-17(18(22)12-23-20)16-8-3-4-9-19(16)28-2/h3-4,8-9,11-12,14-15H,5-7,10H2,1-2H3,(H,24,26)(H,23,25,27) VDXWHBPYYAUMKG-UHFFFAOYSA-N 795183 US12570607, Example 17 Cyclin-dependent kinase 2 Homo sapiens 1435 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795183&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492008 528826646 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741453 COc1ccccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H24FN3O3/c1-13(26)24-15-7-5-6-14(10-15)21(27)25-20-11-17(18(22)12-23-20)16-8-3-4-9-19(16)28-2/h3-4,8-9,11-12,14-15H,5-7,10H2,1-2H3,(H,24,26)(H,23,25,27) VDXWHBPYYAUMKG-UHFFFAOYSA-N 795183 US12570607, Example 17 Cyclin-dependent kinase 4 Homo sapiens 474 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795183&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492008 528826646 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741454 COc1ccccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H24FN3O3/c1-13(26)24-15-7-5-6-14(10-15)21(27)25-20-11-17(18(22)12-23-20)16-8-3-4-9-19(16)28-2/h3-4,8-9,11-12,14-15H,5-7,10H2,1-2H3,(H,24,26)(H,23,25,27) VDXWHBPYYAUMKG-UHFFFAOYSA-N 795183 US12570607, Example 17 Cyclin-dependent kinase 5 Homo sapiens 357 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795183&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492008 528826646 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741455 COc1ccccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H24FN3O3/c1-13(26)24-15-7-5-6-14(10-15)21(27)25-20-11-17(18(22)12-23-20)16-8-3-4-9-19(16)28-2/h3-4,8-9,11-12,14-15H,5-7,10H2,1-2H3,(H,24,26)(H,23,25,27) VDXWHBPYYAUMKG-UHFFFAOYSA-N 795183 US12570607, Example 17 Cyclin-dependent kinase 6 Homo sapiens 3170 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492008 528826646 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741456 COc1ccccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H24FN3O3/c1-13(26)24-15-7-5-6-14(10-15)21(27)25-20-11-17(18(22)12-23-20)16-8-3-4-9-19(16)28-2/h3-4,8-9,11-12,14-15H,5-7,10H2,1-2H3,(H,24,26)(H,23,25,27) VDXWHBPYYAUMKG-UHFFFAOYSA-N 795183 US12570607, Example 17 Cyclin-dependent kinase 7 Homo sapiens 5480 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795183&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492008 528826646 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741457 COc1ccccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1F InChI=1S/C21H24FN3O3/c1-13(26)24-15-7-5-6-14(10-15)21(27)25-20-11-17(18(22)12-23-20)16-8-3-4-9-19(16)28-2/h3-4,8-9,11-12,14-15H,5-7,10H2,1-2H3,(H,24,26)(H,23,25,27) VDXWHBPYYAUMKG-UHFFFAOYSA-N 795183 US12570607, Example 17 Cyclin-dependent kinase 9 Homo sapiens 7.12 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795183&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492008 528826646 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741458 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cccc4ccoc34)c(F)cn2)C1 InChI=1S/C22H22FN3O3/c1-13(27)25-16-6-2-5-15(10-16)22(28)26-20-11-18(19(23)12-24-20)17-7-3-4-14-8-9-29-21(14)17/h3-4,7-9,11-12,15-16H,2,5-6,10H2,1H3,(H,25,27)(H,24,26,28) AGYXQWBXASLLLW-UHFFFAOYSA-N 795184 US12570607, Example 19 Cyclin-dependent kinase 1 Homo sapiens 87.1 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795184&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156491953 528826647 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741459 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cccc4ccoc34)c(F)cn2)C1 InChI=1S/C22H22FN3O3/c1-13(27)25-16-6-2-5-15(10-16)22(28)26-20-11-18(19(23)12-24-20)17-7-3-4-14-8-9-29-21(14)17/h3-4,7-9,11-12,15-16H,2,5-6,10H2,1H3,(H,25,27)(H,24,26,28) AGYXQWBXASLLLW-UHFFFAOYSA-N 795184 US12570607, Example 19 Cyclin-dependent kinase 2 Homo sapiens 638 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795184&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156491953 528826647 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741460 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cccc4ccoc34)c(F)cn2)C1 InChI=1S/C22H22FN3O3/c1-13(27)25-16-6-2-5-15(10-16)22(28)26-20-11-18(19(23)12-24-20)17-7-3-4-14-8-9-29-21(14)17/h3-4,7-9,11-12,15-16H,2,5-6,10H2,1H3,(H,25,27)(H,24,26,28) AGYXQWBXASLLLW-UHFFFAOYSA-N 795184 US12570607, Example 19 Cyclin-dependent kinase 4 Homo sapiens 196 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795184&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156491953 528826647 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741461 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cccc4ccoc34)c(F)cn2)C1 InChI=1S/C22H22FN3O3/c1-13(27)25-16-6-2-5-15(10-16)22(28)26-20-11-18(19(23)12-24-20)17-7-3-4-14-8-9-29-21(14)17/h3-4,7-9,11-12,15-16H,2,5-6,10H2,1H3,(H,25,27)(H,24,26,28) AGYXQWBXASLLLW-UHFFFAOYSA-N 795184 US12570607, Example 19 Cyclin-dependent kinase 5 Homo sapiens 293 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795184&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156491953 528826647 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741462 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cccc4ccoc34)c(F)cn2)C1 InChI=1S/C22H22FN3O3/c1-13(27)25-16-6-2-5-15(10-16)22(28)26-20-11-18(19(23)12-24-20)17-7-3-4-14-8-9-29-21(14)17/h3-4,7-9,11-12,15-16H,2,5-6,10H2,1H3,(H,25,27)(H,24,26,28) AGYXQWBXASLLLW-UHFFFAOYSA-N 795184 US12570607, Example 19 Cyclin-dependent kinase 6 Homo sapiens 297 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795184&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156491953 528826647 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741463 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cccc4ccoc34)c(F)cn2)C1 InChI=1S/C22H22FN3O3/c1-13(27)25-16-6-2-5-15(10-16)22(28)26-20-11-18(19(23)12-24-20)17-7-3-4-14-8-9-29-21(14)17/h3-4,7-9,11-12,15-16H,2,5-6,10H2,1H3,(H,25,27)(H,24,26,28) AGYXQWBXASLLLW-UHFFFAOYSA-N 795184 US12570607, Example 19 Cyclin-dependent kinase 7 Homo sapiens 1171 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795184&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156491953 528826647 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741464 CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cccc4ccoc34)c(F)cn2)C1 InChI=1S/C22H22FN3O3/c1-13(27)25-16-6-2-5-15(10-16)22(28)26-20-11-18(19(23)12-24-20)17-7-3-4-14-8-9-29-21(14)17/h3-4,7-9,11-12,15-16H,2,5-6,10H2,1H3,(H,25,27)(H,24,26,28) AGYXQWBXASLLLW-UHFFFAOYSA-N 795184 US12570607, Example 19 Cyclin-dependent kinase 9 Homo sapiens 7.65 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795184&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156491953 528826647 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741465 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NS(C)(=O)=O)C2)ncc1F InChI=1S/C20H23F2N3O4S/c1-29-18-9-13(21)6-7-15(18)16-10-19(23-11-17(16)22)24-20(26)12-4-3-5-14(8-12)25-30(2,27)28/h6-7,9-12,14,25H,3-5,8H2,1-2H3,(H,23,24,26) GYLOJCGKPMVKCQ-UHFFFAOYSA-N 795185 US12570607, Example 25 Cyclin-dependent kinase 1 Homo sapiens 265 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795185&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492088 528826648 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741466 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NS(C)(=O)=O)C2)ncc1F InChI=1S/C20H23F2N3O4S/c1-29-18-9-13(21)6-7-15(18)16-10-19(23-11-17(16)22)24-20(26)12-4-3-5-14(8-12)25-30(2,27)28/h6-7,9-12,14,25H,3-5,8H2,1-2H3,(H,23,24,26) GYLOJCGKPMVKCQ-UHFFFAOYSA-N 795185 US12570607, Example 25 Cyclin-dependent kinase 2 Homo sapiens 2049 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795185&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492088 528826648 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741467 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NS(C)(=O)=O)C2)ncc1F InChI=1S/C20H23F2N3O4S/c1-29-18-9-13(21)6-7-15(18)16-10-19(23-11-17(16)22)24-20(26)12-4-3-5-14(8-12)25-30(2,27)28/h6-7,9-12,14,25H,3-5,8H2,1-2H3,(H,23,24,26) GYLOJCGKPMVKCQ-UHFFFAOYSA-N 795185 US12570607, Example 25 Cyclin-dependent kinase 4 Homo sapiens 811 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795185&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492088 528826648 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741468 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NS(C)(=O)=O)C2)ncc1F InChI=1S/C20H23F2N3O4S/c1-29-18-9-13(21)6-7-15(18)16-10-19(23-11-17(16)22)24-20(26)12-4-3-5-14(8-12)25-30(2,27)28/h6-7,9-12,14,25H,3-5,8H2,1-2H3,(H,23,24,26) GYLOJCGKPMVKCQ-UHFFFAOYSA-N 795185 US12570607, Example 25 Cyclin-dependent kinase 5 Homo sapiens 716 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795185&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492088 528826648 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741469 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NS(C)(=O)=O)C2)ncc1F InChI=1S/C20H23F2N3O4S/c1-29-18-9-13(21)6-7-15(18)16-10-19(23-11-17(16)22)24-20(26)12-4-3-5-14(8-12)25-30(2,27)28/h6-7,9-12,14,25H,3-5,8H2,1-2H3,(H,23,24,26) GYLOJCGKPMVKCQ-UHFFFAOYSA-N 795185 US12570607, Example 25 Cyclin-dependent kinase 6 Homo sapiens 2359 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795185&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492088 528826648 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741470 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NS(C)(=O)=O)C2)ncc1F InChI=1S/C20H23F2N3O4S/c1-29-18-9-13(21)6-7-15(18)16-10-19(23-11-17(16)22)24-20(26)12-4-3-5-14(8-12)25-30(2,27)28/h6-7,9-12,14,25H,3-5,8H2,1-2H3,(H,23,24,26) GYLOJCGKPMVKCQ-UHFFFAOYSA-N 795185 US12570607, Example 25 Cyclin-dependent kinase 7 Homo sapiens 4359 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795185&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492088 528826648 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741471 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NS(C)(=O)=O)C2)ncc1F InChI=1S/C20H23F2N3O4S/c1-29-18-9-13(21)6-7-15(18)16-10-19(23-11-17(16)22)24-20(26)12-4-3-5-14(8-12)25-30(2,27)28/h6-7,9-12,14,25H,3-5,8H2,1-2H3,(H,23,24,26) GYLOJCGKPMVKCQ-UHFFFAOYSA-N 795185 US12570607, Example 25 Cyclin-dependent kinase 9 Homo sapiens 7.54 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795185&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492088 528826648 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741472 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CC#N)C2)ncc1F InChI=1S/C22H22F2N4O3/c1-31-19-10-14(23)5-6-16(19)17-11-20(26-12-18(17)24)28-22(30)13-3-2-4-15(9-13)27-21(29)7-8-25/h5-6,10-13,15H,2-4,7,9H2,1H3,(H,27,29)(H,26,28,30) FRPIQMYIZYSHJA-UHFFFAOYSA-N 795186 US12570607, Example 32 Cyclin-dependent kinase 1 Homo sapiens 86.7 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795186&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169677829 528826649 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741473 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CC#N)C2)ncc1F InChI=1S/C22H22F2N4O3/c1-31-19-10-14(23)5-6-16(19)17-11-20(26-12-18(17)24)28-22(30)13-3-2-4-15(9-13)27-21(29)7-8-25/h5-6,10-13,15H,2-4,7,9H2,1H3,(H,27,29)(H,26,28,30) FRPIQMYIZYSHJA-UHFFFAOYSA-N 795186 US12570607, Example 32 Cyclin-dependent kinase 2 Homo sapiens 1071 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795186&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 169677829 528826649 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741474 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CC#N)C2)ncc1F InChI=1S/C22H22F2N4O3/c1-31-19-10-14(23)5-6-16(19)17-11-20(26-12-18(17)24)28-22(30)13-3-2-4-15(9-13)27-21(29)7-8-25/h5-6,10-13,15H,2-4,7,9H2,1H3,(H,27,29)(H,26,28,30) FRPIQMYIZYSHJA-UHFFFAOYSA-N 795186 US12570607, Example 32 Cyclin-dependent kinase 4 Homo sapiens 353 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795186&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 169677829 528826649 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741475 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CC#N)C2)ncc1F InChI=1S/C22H22F2N4O3/c1-31-19-10-14(23)5-6-16(19)17-11-20(26-12-18(17)24)28-22(30)13-3-2-4-15(9-13)27-21(29)7-8-25/h5-6,10-13,15H,2-4,7,9H2,1H3,(H,27,29)(H,26,28,30) FRPIQMYIZYSHJA-UHFFFAOYSA-N 795186 US12570607, Example 32 Cyclin-dependent kinase 5 Homo sapiens 329 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795186&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 169677829 528826649 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741476 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CC#N)C2)ncc1F InChI=1S/C22H22F2N4O3/c1-31-19-10-14(23)5-6-16(19)17-11-20(26-12-18(17)24)28-22(30)13-3-2-4-15(9-13)27-21(29)7-8-25/h5-6,10-13,15H,2-4,7,9H2,1H3,(H,27,29)(H,26,28,30) FRPIQMYIZYSHJA-UHFFFAOYSA-N 795186 US12570607, Example 32 Cyclin-dependent kinase 6 Homo sapiens 2446 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795186&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169677829 528826649 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741477 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CC#N)C2)ncc1F InChI=1S/C22H22F2N4O3/c1-31-19-10-14(23)5-6-16(19)17-11-20(26-12-18(17)24)28-22(30)13-3-2-4-15(9-13)27-21(29)7-8-25/h5-6,10-13,15H,2-4,7,9H2,1H3,(H,27,29)(H,26,28,30) FRPIQMYIZYSHJA-UHFFFAOYSA-N 795186 US12570607, Example 32 Cyclin-dependent kinase 7 Homo sapiens 1647 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795186&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 169677829 528826649 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741478 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CC#N)C2)ncc1F InChI=1S/C22H22F2N4O3/c1-31-19-10-14(23)5-6-16(19)17-11-20(26-12-18(17)24)28-22(30)13-3-2-4-15(9-13)27-21(29)7-8-25/h5-6,10-13,15H,2-4,7,9H2,1H3,(H,27,29)(H,26,28,30) FRPIQMYIZYSHJA-UHFFFAOYSA-N 795186 US12570607, Example 32 Cyclin-dependent kinase 9 Homo sapiens 6.86 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795186&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169677829 528826649 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741479 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H24F2N4O3/c1-33-20-10-15(25)5-6-17(20)18-11-21(28-12-19(18)26)30-22(31)14-3-2-4-16(9-14)29-23(32)24(13-27)7-8-24/h5-6,10-12,14,16H,2-4,7-9H2,1H3,(H,29,32)(H,28,30,31) PPSNIGDYHAQAES-UHFFFAOYSA-N 795187 US12570607, Example 33 Cyclin-dependent kinase 1 Homo sapiens 78.8 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795187&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492026 528826650 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741480 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H24F2N4O3/c1-33-20-10-15(25)5-6-17(20)18-11-21(28-12-19(18)26)30-22(31)14-3-2-4-16(9-14)29-23(32)24(13-27)7-8-24/h5-6,10-12,14,16H,2-4,7-9H2,1H3,(H,29,32)(H,28,30,31) PPSNIGDYHAQAES-UHFFFAOYSA-N 795187 US12570607, Example 33 Cyclin-dependent kinase 2 Homo sapiens 761 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795187&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492026 528826650 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741481 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H24F2N4O3/c1-33-20-10-15(25)5-6-17(20)18-11-21(28-12-19(18)26)30-22(31)14-3-2-4-16(9-14)29-23(32)24(13-27)7-8-24/h5-6,10-12,14,16H,2-4,7-9H2,1H3,(H,29,32)(H,28,30,31) PPSNIGDYHAQAES-UHFFFAOYSA-N 795187 US12570607, Example 33 Cyclin-dependent kinase 4 Homo sapiens 395 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795187&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492026 528826650 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741482 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H24F2N4O3/c1-33-20-10-15(25)5-6-17(20)18-11-21(28-12-19(18)26)30-22(31)14-3-2-4-16(9-14)29-23(32)24(13-27)7-8-24/h5-6,10-12,14,16H,2-4,7-9H2,1H3,(H,29,32)(H,28,30,31) PPSNIGDYHAQAES-UHFFFAOYSA-N 795187 US12570607, Example 33 Cyclin-dependent kinase 5 Homo sapiens 168 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795187&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492026 528826650 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741483 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H24F2N4O3/c1-33-20-10-15(25)5-6-17(20)18-11-21(28-12-19(18)26)30-22(31)14-3-2-4-16(9-14)29-23(32)24(13-27)7-8-24/h5-6,10-12,14,16H,2-4,7-9H2,1H3,(H,29,32)(H,28,30,31) PPSNIGDYHAQAES-UHFFFAOYSA-N 795187 US12570607, Example 33 Cyclin-dependent kinase 6 Homo sapiens 1763 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795187&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492026 528826650 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741484 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H24F2N4O3/c1-33-20-10-15(25)5-6-17(20)18-11-21(28-12-19(18)26)30-22(31)14-3-2-4-16(9-14)29-23(32)24(13-27)7-8-24/h5-6,10-12,14,16H,2-4,7-9H2,1H3,(H,29,32)(H,28,30,31) PPSNIGDYHAQAES-UHFFFAOYSA-N 795187 US12570607, Example 33 Cyclin-dependent kinase 7 Homo sapiens 1258 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795187&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492026 528826650 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741485 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H24F2N4O3/c1-33-20-10-15(25)5-6-17(20)18-11-21(28-12-19(18)26)30-22(31)14-3-2-4-16(9-14)29-23(32)24(13-27)7-8-24/h5-6,10-12,14,16H,2-4,7-9H2,1H3,(H,29,32)(H,28,30,31) PPSNIGDYHAQAES-UHFFFAOYSA-N 795187 US12570607, Example 33 Cyclin-dependent kinase 9 Homo sapiens 6.68 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795187&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492026 528826650 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741486 COC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H23F2N3O4/c1-29-18-9-13(22)6-7-15(18)16-10-19(24-11-17(16)23)26-20(27)12-4-3-5-14(8-12)25-21(28)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H,25,28)(H,24,26,27) IVNYJQIDDWNRFO-UHFFFAOYSA-N 795188 US12570607, Example 36 Cyclin-dependent kinase 1 Homo sapiens 97.0 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795188&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169677828 528826651 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741487 COC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H23F2N3O4/c1-29-18-9-13(22)6-7-15(18)16-10-19(24-11-17(16)23)26-20(27)12-4-3-5-14(8-12)25-21(28)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H,25,28)(H,24,26,27) IVNYJQIDDWNRFO-UHFFFAOYSA-N 795188 US12570607, Example 36 Cyclin-dependent kinase 2 Homo sapiens 558 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795188&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 169677828 528826651 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741488 COC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H23F2N3O4/c1-29-18-9-13(22)6-7-15(18)16-10-19(24-11-17(16)23)26-20(27)12-4-3-5-14(8-12)25-21(28)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H,25,28)(H,24,26,27) IVNYJQIDDWNRFO-UHFFFAOYSA-N 795188 US12570607, Example 36 Cyclin-dependent kinase 4 Homo sapiens 630 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795188&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 169677828 528826651 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741489 COC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H23F2N3O4/c1-29-18-9-13(22)6-7-15(18)16-10-19(24-11-17(16)23)26-20(27)12-4-3-5-14(8-12)25-21(28)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H,25,28)(H,24,26,27) IVNYJQIDDWNRFO-UHFFFAOYSA-N 795188 US12570607, Example 36 Cyclin-dependent kinase 5 Homo sapiens 209 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795188&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 169677828 528826651 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741490 COC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H23F2N3O4/c1-29-18-9-13(22)6-7-15(18)16-10-19(24-11-17(16)23)26-20(27)12-4-3-5-14(8-12)25-21(28)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H,25,28)(H,24,26,27) IVNYJQIDDWNRFO-UHFFFAOYSA-N 795188 US12570607, Example 36 Cyclin-dependent kinase 6 Homo sapiens 3374 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795188&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169677828 528826651 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741491 COC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H23F2N3O4/c1-29-18-9-13(22)6-7-15(18)16-10-19(24-11-17(16)23)26-20(27)12-4-3-5-14(8-12)25-21(28)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H,25,28)(H,24,26,27) IVNYJQIDDWNRFO-UHFFFAOYSA-N 795188 US12570607, Example 36 Cyclin-dependent kinase 7 Homo sapiens 3717 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795188&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 169677828 528826651 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741492 COC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H23F2N3O4/c1-29-18-9-13(22)6-7-15(18)16-10-19(24-11-17(16)23)26-20(27)12-4-3-5-14(8-12)25-21(28)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H,25,28)(H,24,26,27) IVNYJQIDDWNRFO-UHFFFAOYSA-N 795188 US12570607, Example 36 Cyclin-dependent kinase 9 Homo sapiens 6.88 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795188&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169677828 528826651 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741493 CNC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H24F2N4O3/c1-24-21(29)26-14-5-3-4-12(8-14)20(28)27-19-10-16(17(23)11-25-19)15-7-6-13(22)9-18(15)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H2,24,26,29)(H,25,27,28) QFVDYOAVRIZIAM-UHFFFAOYSA-N 795189 US12570607, Example 37 Cyclin-dependent kinase 1 Homo sapiens 82.0 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795189&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492156 528826652 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741494 CNC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H24F2N4O3/c1-24-21(29)26-14-5-3-4-12(8-14)20(28)27-19-10-16(17(23)11-25-19)15-7-6-13(22)9-18(15)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H2,24,26,29)(H,25,27,28) QFVDYOAVRIZIAM-UHFFFAOYSA-N 795189 US12570607, Example 37 Cyclin-dependent kinase 2 Homo sapiens 688 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795189&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492156 528826652 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741495 CNC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H24F2N4O3/c1-24-21(29)26-14-5-3-4-12(8-14)20(28)27-19-10-16(17(23)11-25-19)15-7-6-13(22)9-18(15)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H2,24,26,29)(H,25,27,28) QFVDYOAVRIZIAM-UHFFFAOYSA-N 795189 US12570607, Example 37 Cyclin-dependent kinase 4 Homo sapiens 361 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795189&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492156 528826652 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741496 CNC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H24F2N4O3/c1-24-21(29)26-14-5-3-4-12(8-14)20(28)27-19-10-16(17(23)11-25-19)15-7-6-13(22)9-18(15)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H2,24,26,29)(H,25,27,28) QFVDYOAVRIZIAM-UHFFFAOYSA-N 795189 US12570607, Example 37 Cyclin-dependent kinase 5 Homo sapiens 248 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795189&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492156 528826652 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741497 CNC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H24F2N4O3/c1-24-21(29)26-14-5-3-4-12(8-14)20(28)27-19-10-16(17(23)11-25-19)15-7-6-13(22)9-18(15)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H2,24,26,29)(H,25,27,28) QFVDYOAVRIZIAM-UHFFFAOYSA-N 795189 US12570607, Example 37 Cyclin-dependent kinase 6 Homo sapiens 2638 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795189&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492156 528826652 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741498 CNC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H24F2N4O3/c1-24-21(29)26-14-5-3-4-12(8-14)20(28)27-19-10-16(17(23)11-25-19)15-7-6-13(22)9-18(15)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H2,24,26,29)(H,25,27,28) QFVDYOAVRIZIAM-UHFFFAOYSA-N 795189 US12570607, Example 37 Cyclin-dependent kinase 7 Homo sapiens 2654 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795189&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492156 528826652 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741499 CNC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3ccc(F)cc3OC)c(F)cn2)C1 InChI=1S/C21H24F2N4O3/c1-24-21(29)26-14-5-3-4-12(8-14)20(28)27-19-10-16(17(23)11-25-19)15-7-6-13(22)9-18(15)30-2/h6-7,9-12,14H,3-5,8H2,1-2H3,(H2,24,26,29)(H,25,27,28) QFVDYOAVRIZIAM-UHFFFAOYSA-N 795189 US12570607, Example 37 Cyclin-dependent kinase 9 Homo sapiens 6.44 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795189&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492156 528826652 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 741500 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)Nc3cc(C)no3)C2)ncc1F InChI=1S/C24H25F2N5O4/c1-13-8-22(35-31-13)30-24(33)28-16-5-3-4-14(9-16)23(32)29-21-11-18(19(26)12-27-21)17-7-6-15(25)10-20(17)34-2/h6-8,10-12,14,16H,3-5,9H2,1-2H3,(H,27,29,32)(H2,28,30,33) ARPYNMZZLGLBRV-UHFFFAOYSA-N 795190 US12570607, Example 41 Cyclin-dependent kinase 1 Homo sapiens 196 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795190&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492036 528826653 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 741501 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)Nc3cc(C)no3)C2)ncc1F InChI=1S/C24H25F2N5O4/c1-13-8-22(35-31-13)30-24(33)28-16-5-3-4-14(9-16)23(32)29-21-11-18(19(26)12-27-21)17-7-6-15(25)10-20(17)34-2/h6-8,10-12,14,16H,3-5,9H2,1-2H3,(H,27,29,32)(H2,28,30,33) ARPYNMZZLGLBRV-UHFFFAOYSA-N 795190 US12570607, Example 41 Cyclin-dependent kinase 2 Homo sapiens 1248 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795190&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492036 528826653 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 741502 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)Nc3cc(C)no3)C2)ncc1F InChI=1S/C24H25F2N5O4/c1-13-8-22(35-31-13)30-24(33)28-16-5-3-4-14(9-16)23(32)29-21-11-18(19(26)12-27-21)17-7-6-15(25)10-20(17)34-2/h6-8,10-12,14,16H,3-5,9H2,1-2H3,(H,27,29,32)(H2,28,30,33) ARPYNMZZLGLBRV-UHFFFAOYSA-N 795190 US12570607, Example 41 Cyclin-dependent kinase 4 Homo sapiens 629 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795190&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492036 528826653 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 741503 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)Nc3cc(C)no3)C2)ncc1F InChI=1S/C24H25F2N5O4/c1-13-8-22(35-31-13)30-24(33)28-16-5-3-4-14(9-16)23(32)29-21-11-18(19(26)12-27-21)17-7-6-15(25)10-20(17)34-2/h6-8,10-12,14,16H,3-5,9H2,1-2H3,(H,27,29,32)(H2,28,30,33) ARPYNMZZLGLBRV-UHFFFAOYSA-N 795190 US12570607, Example 41 Cyclin-dependent kinase 5 Homo sapiens 361 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795190&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492036 528826653 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 741504 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)Nc3cc(C)no3)C2)ncc1F InChI=1S/C24H25F2N5O4/c1-13-8-22(35-31-13)30-24(33)28-16-5-3-4-14(9-16)23(32)29-21-11-18(19(26)12-27-21)17-7-6-15(25)10-20(17)34-2/h6-8,10-12,14,16H,3-5,9H2,1-2H3,(H,27,29,32)(H2,28,30,33) ARPYNMZZLGLBRV-UHFFFAOYSA-N 795190 US12570607, Example 41 Cyclin-dependent kinase 6 Homo sapiens 4978 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795190&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492036 528826653 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 741505 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)Nc3cc(C)no3)C2)ncc1F InChI=1S/C24H25F2N5O4/c1-13-8-22(35-31-13)30-24(33)28-16-5-3-4-14(9-16)23(32)29-21-11-18(19(26)12-27-21)17-7-6-15(25)10-20(17)34-2/h6-8,10-12,14,16H,3-5,9H2,1-2H3,(H,27,29,32)(H2,28,30,33) ARPYNMZZLGLBRV-UHFFFAOYSA-N 795190 US12570607, Example 41 Cyclin-dependent kinase 7 Homo sapiens 1083 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795190&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492036 528826653 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 741506 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)Nc3cc(C)no3)C2)ncc1F InChI=1S/C24H25F2N5O4/c1-13-8-22(35-31-13)30-24(33)28-16-5-3-4-14(9-16)23(32)29-21-11-18(19(26)12-27-21)17-7-6-15(25)10-20(17)34-2/h6-8,10-12,14,16H,3-5,9H2,1-2H3,(H,27,29,32)(H2,28,30,33) ARPYNMZZLGLBRV-UHFFFAOYSA-N 795190 US12570607, Example 41 Cyclin-dependent kinase 9 Homo sapiens 7.65 US Patent 10.7270/Q2HQ44VW aid1798225 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795190&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492036 528826653 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 744280 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C(F)(F)F)C2)ncc1F InChI=1S/C21H20F5N3O3/c1-32-17-8-12(22)5-6-14(17)15-9-18(27-10-16(15)23)29-19(30)11-3-2-4-13(7-11)28-20(31)21(24,25)26/h5-6,8-11,13H,2-4,7H2,1H3,(H,28,31)(H,27,29,30) VIKODMKSCHKSJX-UHFFFAOYSA-N 795191 US12570607, Example 42 Cyclin-dependent kinase 1 Homo sapiens 72.6 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795191&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492019 528826654 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 744281 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C(F)(F)F)C2)ncc1F InChI=1S/C21H20F5N3O3/c1-32-17-8-12(22)5-6-14(17)15-9-18(27-10-16(15)23)29-19(30)11-3-2-4-13(7-11)28-20(31)21(24,25)26/h5-6,8-11,13H,2-4,7H2,1H3,(H,28,31)(H,27,29,30) VIKODMKSCHKSJX-UHFFFAOYSA-N 795191 US12570607, Example 42 Cyclin-dependent kinase 2 Homo sapiens 253 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795191&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492019 528826654 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 744282 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C(F)(F)F)C2)ncc1F InChI=1S/C21H20F5N3O3/c1-32-17-8-12(22)5-6-14(17)15-9-18(27-10-16(15)23)29-19(30)11-3-2-4-13(7-11)28-20(31)21(24,25)26/h5-6,8-11,13H,2-4,7H2,1H3,(H,28,31)(H,27,29,30) VIKODMKSCHKSJX-UHFFFAOYSA-N 795191 US12570607, Example 42 Cyclin-dependent kinase 4 Homo sapiens 184 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795191&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492019 528826654 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 744283 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C(F)(F)F)C2)ncc1F InChI=1S/C21H20F5N3O3/c1-32-17-8-12(22)5-6-14(17)15-9-18(27-10-16(15)23)29-19(30)11-3-2-4-13(7-11)28-20(31)21(24,25)26/h5-6,8-11,13H,2-4,7H2,1H3,(H,28,31)(H,27,29,30) VIKODMKSCHKSJX-UHFFFAOYSA-N 795191 US12570607, Example 42 Cyclin-dependent kinase 5 Homo sapiens 140 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795191&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492019 528826654 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 744284 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C(F)(F)F)C2)ncc1F InChI=1S/C21H20F5N3O3/c1-32-17-8-12(22)5-6-14(17)15-9-18(27-10-16(15)23)29-19(30)11-3-2-4-13(7-11)28-20(31)21(24,25)26/h5-6,8-11,13H,2-4,7H2,1H3,(H,28,31)(H,27,29,30) VIKODMKSCHKSJX-UHFFFAOYSA-N 795191 US12570607, Example 42 Cyclin-dependent kinase 6 Homo sapiens 1014 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795191&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492019 528826654 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 744285 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C(F)(F)F)C2)ncc1F InChI=1S/C21H20F5N3O3/c1-32-17-8-12(22)5-6-14(17)15-9-18(27-10-16(15)23)29-19(30)11-3-2-4-13(7-11)28-20(31)21(24,25)26/h5-6,8-11,13H,2-4,7H2,1H3,(H,28,31)(H,27,29,30) VIKODMKSCHKSJX-UHFFFAOYSA-N 795191 US12570607, Example 42 Cyclin-dependent kinase 7 Homo sapiens 992 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795191&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492019 528826654 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 744286 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C(F)(F)F)C2)ncc1F InChI=1S/C21H20F5N3O3/c1-32-17-8-12(22)5-6-14(17)15-9-18(27-10-16(15)23)29-19(30)11-3-2-4-13(7-11)28-20(31)21(24,25)26/h5-6,8-11,13H,2-4,7H2,1H3,(H,28,31)(H,27,29,30) VIKODMKSCHKSJX-UHFFFAOYSA-N 795191 US12570607, Example 42 Cyclin-dependent kinase 9 Homo sapiens 6.66 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795191&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492019 528826654 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 744287 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)c3ccccn3)C2)ncc1F InChI=1S/C25H24F2N4O3/c1-34-22-12-16(26)8-9-18(22)19-13-23(29-14-20(19)27)31-24(32)15-5-4-6-17(11-15)30-25(33)21-7-2-3-10-28-21/h2-3,7-10,12-15,17H,4-6,11H2,1H3,(H,30,33)(H,29,31,32) JDVPBPREIZBJLU-UHFFFAOYSA-N 795192 US12570607, Example 43 Cyclin-dependent kinase 1 Homo sapiens 80.0 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795192&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492028 528826655 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 744288 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)c3ccccn3)C2)ncc1F InChI=1S/C25H24F2N4O3/c1-34-22-12-16(26)8-9-18(22)19-13-23(29-14-20(19)27)31-24(32)15-5-4-6-17(11-15)30-25(33)21-7-2-3-10-28-21/h2-3,7-10,12-15,17H,4-6,11H2,1H3,(H,30,33)(H,29,31,32) JDVPBPREIZBJLU-UHFFFAOYSA-N 795192 US12570607, Example 43 Cyclin-dependent kinase 2 Homo sapiens 823 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795192&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492028 528826655 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 744289 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)c3ccccn3)C2)ncc1F InChI=1S/C25H24F2N4O3/c1-34-22-12-16(26)8-9-18(22)19-13-23(29-14-20(19)27)31-24(32)15-5-4-6-17(11-15)30-25(33)21-7-2-3-10-28-21/h2-3,7-10,12-15,17H,4-6,11H2,1H3,(H,30,33)(H,29,31,32) JDVPBPREIZBJLU-UHFFFAOYSA-N 795192 US12570607, Example 43 Cyclin-dependent kinase 4 Homo sapiens 582 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795192&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492028 528826655 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 744290 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)c3ccccn3)C2)ncc1F InChI=1S/C25H24F2N4O3/c1-34-22-12-16(26)8-9-18(22)19-13-23(29-14-20(19)27)31-24(32)15-5-4-6-17(11-15)30-25(33)21-7-2-3-10-28-21/h2-3,7-10,12-15,17H,4-6,11H2,1H3,(H,30,33)(H,29,31,32) JDVPBPREIZBJLU-UHFFFAOYSA-N 795192 US12570607, Example 43 Cyclin-dependent kinase 5 Homo sapiens 296 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795192&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492028 528826655 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 744291 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)c3ccccn3)C2)ncc1F InChI=1S/C25H24F2N4O3/c1-34-22-12-16(26)8-9-18(22)19-13-23(29-14-20(19)27)31-24(32)15-5-4-6-17(11-15)30-25(33)21-7-2-3-10-28-21/h2-3,7-10,12-15,17H,4-6,11H2,1H3,(H,30,33)(H,29,31,32) JDVPBPREIZBJLU-UHFFFAOYSA-N 795192 US12570607, Example 43 Cyclin-dependent kinase 6 Homo sapiens 3078 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795192&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492028 528826655 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 744292 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)c3ccccn3)C2)ncc1F InChI=1S/C25H24F2N4O3/c1-34-22-12-16(26)8-9-18(22)19-13-23(29-14-20(19)27)31-24(32)15-5-4-6-17(11-15)30-25(33)21-7-2-3-10-28-21/h2-3,7-10,12-15,17H,4-6,11H2,1H3,(H,30,33)(H,29,31,32) JDVPBPREIZBJLU-UHFFFAOYSA-N 795192 US12570607, Example 43 Cyclin-dependent kinase 7 Homo sapiens 2407 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795192&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492028 528826655 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 744293 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)c3ccccn3)C2)ncc1F InChI=1S/C25H24F2N4O3/c1-34-22-12-16(26)8-9-18(22)19-13-23(29-14-20(19)27)31-24(32)15-5-4-6-17(11-15)30-25(33)21-7-2-3-10-28-21/h2-3,7-10,12-15,17H,4-6,11H2,1H3,(H,30,33)(H,29,31,32) JDVPBPREIZBJLU-UHFFFAOYSA-N 795192 US12570607, Example 43 Cyclin-dependent kinase 9 Homo sapiens 7.17 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795192&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492028 528826655 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 744294 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H23F2N3O4/c1-30-18-8-13(22)5-6-15(18)16-9-19(24-10-17(16)23)26-21(29)12-3-2-4-14(7-12)25-20(28)11-27/h5-6,8-10,12,14,27H,2-4,7,11H2,1H3,(H,25,28)(H,24,26,29) KIRQDLPHJNLSDF-UHFFFAOYSA-N 795193 US12570607, Example 45 Cyclin-dependent kinase 1 Homo sapiens 93.2 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795193&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492075 528826656 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 744295 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H23F2N3O4/c1-30-18-8-13(22)5-6-15(18)16-9-19(24-10-17(16)23)26-21(29)12-3-2-4-14(7-12)25-20(28)11-27/h5-6,8-10,12,14,27H,2-4,7,11H2,1H3,(H,25,28)(H,24,26,29) KIRQDLPHJNLSDF-UHFFFAOYSA-N 795193 US12570607, Example 45 Cyclin-dependent kinase 2 Homo sapiens 564 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795193&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492075 528826656 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 744296 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H23F2N3O4/c1-30-18-8-13(22)5-6-15(18)16-9-19(24-10-17(16)23)26-21(29)12-3-2-4-14(7-12)25-20(28)11-27/h5-6,8-10,12,14,27H,2-4,7,11H2,1H3,(H,25,28)(H,24,26,29) KIRQDLPHJNLSDF-UHFFFAOYSA-N 795193 US12570607, Example 45 Cyclin-dependent kinase 4 Homo sapiens 785 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795193&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492075 528826656 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 744297 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H23F2N3O4/c1-30-18-8-13(22)5-6-15(18)16-9-19(24-10-17(16)23)26-21(29)12-3-2-4-14(7-12)25-20(28)11-27/h5-6,8-10,12,14,27H,2-4,7,11H2,1H3,(H,25,28)(H,24,26,29) KIRQDLPHJNLSDF-UHFFFAOYSA-N 795193 US12570607, Example 45 Cyclin-dependent kinase 5 Homo sapiens 284 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795193&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492075 528826656 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 744298 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H23F2N3O4/c1-30-18-8-13(22)5-6-15(18)16-9-19(24-10-17(16)23)26-21(29)12-3-2-4-14(7-12)25-20(28)11-27/h5-6,8-10,12,14,27H,2-4,7,11H2,1H3,(H,25,28)(H,24,26,29) KIRQDLPHJNLSDF-UHFFFAOYSA-N 795193 US12570607, Example 45 Cyclin-dependent kinase 6 Homo sapiens 2795 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795193&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492075 528826656 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 744299 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H23F2N3O4/c1-30-18-8-13(22)5-6-15(18)16-9-19(24-10-17(16)23)26-21(29)12-3-2-4-14(7-12)25-20(28)11-27/h5-6,8-10,12,14,27H,2-4,7,11H2,1H3,(H,25,28)(H,24,26,29) KIRQDLPHJNLSDF-UHFFFAOYSA-N 795193 US12570607, Example 45 Cyclin-dependent kinase 7 Homo sapiens 4444 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795193&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492075 528826656 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 744300 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H23F2N3O4/c1-30-18-8-13(22)5-6-15(18)16-9-19(24-10-17(16)23)26-21(29)12-3-2-4-14(7-12)25-20(28)11-27/h5-6,8-10,12,14,27H,2-4,7,11H2,1H3,(H,25,28)(H,24,26,29) KIRQDLPHJNLSDF-UHFFFAOYSA-N 795193 US12570607, Example 45 Cyclin-dependent kinase 9 Homo sapiens 6.92 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795193&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492075 528826656 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 744301 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)[C@H](C)O)C2)ncc1F InChI=1S/C22H25F2N3O4/c1-12(28)21(29)26-15-5-3-4-13(8-15)22(30)27-20-10-17(18(24)11-25-20)16-7-6-14(23)9-19(16)31-2/h6-7,9-13,15,28H,3-5,8H2,1-2H3,(H,26,29)(H,25,27,30) CYHAOAAOEWBNTN-UHFFFAOYSA-N 795194 US12570607, Example 48 Cyclin-dependent kinase 1 Homo sapiens 133 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795194&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169677890 528826657 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 744302 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)[C@H](C)O)C2)ncc1F InChI=1S/C22H25F2N3O4/c1-12(28)21(29)26-15-5-3-4-13(8-15)22(30)27-20-10-17(18(24)11-25-20)16-7-6-14(23)9-19(16)31-2/h6-7,9-13,15,28H,3-5,8H2,1-2H3,(H,26,29)(H,25,27,30) CYHAOAAOEWBNTN-UHFFFAOYSA-N 795194 US12570607, Example 48 Cyclin-dependent kinase 2 Homo sapiens 776 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795194&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 169677890 528826657 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 744303 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)[C@H](C)O)C2)ncc1F InChI=1S/C22H25F2N3O4/c1-12(28)21(29)26-15-5-3-4-13(8-15)22(30)27-20-10-17(18(24)11-25-20)16-7-6-14(23)9-19(16)31-2/h6-7,9-13,15,28H,3-5,8H2,1-2H3,(H,26,29)(H,25,27,30) CYHAOAAOEWBNTN-UHFFFAOYSA-N 795194 US12570607, Example 48 Cyclin-dependent kinase 4 Homo sapiens 767 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795194&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 169677890 528826657 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 744304 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)[C@H](C)O)C2)ncc1F InChI=1S/C22H25F2N3O4/c1-12(28)21(29)26-15-5-3-4-13(8-15)22(30)27-20-10-17(18(24)11-25-20)16-7-6-14(23)9-19(16)31-2/h6-7,9-13,15,28H,3-5,8H2,1-2H3,(H,26,29)(H,25,27,30) CYHAOAAOEWBNTN-UHFFFAOYSA-N 795194 US12570607, Example 48 Cyclin-dependent kinase 5 Homo sapiens 301 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795194&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 169677890 528826657 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 744305 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)[C@H](C)O)C2)ncc1F InChI=1S/C22H25F2N3O4/c1-12(28)21(29)26-15-5-3-4-13(8-15)22(30)27-20-10-17(18(24)11-25-20)16-7-6-14(23)9-19(16)31-2/h6-7,9-13,15,28H,3-5,8H2,1-2H3,(H,26,29)(H,25,27,30) CYHAOAAOEWBNTN-UHFFFAOYSA-N 795194 US12570607, Example 48 Cyclin-dependent kinase 6 Homo sapiens 3628 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795194&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169677890 528826657 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 744306 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)[C@H](C)O)C2)ncc1F InChI=1S/C22H25F2N3O4/c1-12(28)21(29)26-15-5-3-4-13(8-15)22(30)27-20-10-17(18(24)11-25-20)16-7-6-14(23)9-19(16)31-2/h6-7,9-13,15,28H,3-5,8H2,1-2H3,(H,26,29)(H,25,27,30) CYHAOAAOEWBNTN-UHFFFAOYSA-N 795194 US12570607, Example 48 Cyclin-dependent kinase 7 Homo sapiens 2151 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795194&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 169677890 528826657 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 744307 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)[C@H](C)O)C2)ncc1F InChI=1S/C22H25F2N3O4/c1-12(28)21(29)26-15-5-3-4-13(8-15)22(30)27-20-10-17(18(24)11-25-20)16-7-6-14(23)9-19(16)31-2/h6-7,9-13,15,28H,3-5,8H2,1-2H3,(H,26,29)(H,25,27,30) CYHAOAAOEWBNTN-UHFFFAOYSA-N 795194 US12570607, Example 48 Cyclin-dependent kinase 9 Homo sapiens 6.84 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795194&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 169677890 528826657 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 744308 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H23F3N4O3/c1-34-20-10-18(26)17(25)8-16(20)15-9-21(29-11-19(15)27)31-22(32)13-3-2-4-14(7-13)30-23(33)24(12-28)5-6-24/h8-11,13-14H,2-7H2,1H3,(H,30,33)(H,29,31,32) FAUUOMXCICCIDU-UHFFFAOYSA-N 795195 US12570607, Example 67 Cyclin-dependent kinase 1 Homo sapiens 67.6 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795195&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492056 528826658 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 744309 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H23F3N4O3/c1-34-20-10-18(26)17(25)8-16(20)15-9-21(29-11-19(15)27)31-22(32)13-3-2-4-14(7-13)30-23(33)24(12-28)5-6-24/h8-11,13-14H,2-7H2,1H3,(H,30,33)(H,29,31,32) FAUUOMXCICCIDU-UHFFFAOYSA-N 795195 US12570607, Example 67 Cyclin-dependent kinase 2 Homo sapiens 392 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795195&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492056 528826658 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 744310 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H23F3N4O3/c1-34-20-10-18(26)17(25)8-16(20)15-9-21(29-11-19(15)27)31-22(32)13-3-2-4-14(7-13)30-23(33)24(12-28)5-6-24/h8-11,13-14H,2-7H2,1H3,(H,30,33)(H,29,31,32) FAUUOMXCICCIDU-UHFFFAOYSA-N 795195 US12570607, Example 67 Cyclin-dependent kinase 4 Homo sapiens 268 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795195&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492056 528826658 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 744311 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H23F3N4O3/c1-34-20-10-18(26)17(25)8-16(20)15-9-21(29-11-19(15)27)31-22(32)13-3-2-4-14(7-13)30-23(33)24(12-28)5-6-24/h8-11,13-14H,2-7H2,1H3,(H,30,33)(H,29,31,32) FAUUOMXCICCIDU-UHFFFAOYSA-N 795195 US12570607, Example 67 Cyclin-dependent kinase 5 Homo sapiens 82.9 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795195&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492056 528826658 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 744312 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H23F3N4O3/c1-34-20-10-18(26)17(25)8-16(20)15-9-21(29-11-19(15)27)31-22(32)13-3-2-4-14(7-13)30-23(33)24(12-28)5-6-24/h8-11,13-14H,2-7H2,1H3,(H,30,33)(H,29,31,32) FAUUOMXCICCIDU-UHFFFAOYSA-N 795195 US12570607, Example 67 Cyclin-dependent kinase 6 Homo sapiens 600 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795195&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492056 528826658 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 744313 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H23F3N4O3/c1-34-20-10-18(26)17(25)8-16(20)15-9-21(29-11-19(15)27)31-22(32)13-3-2-4-14(7-13)30-23(33)24(12-28)5-6-24/h8-11,13-14H,2-7H2,1H3,(H,30,33)(H,29,31,32) FAUUOMXCICCIDU-UHFFFAOYSA-N 795195 US12570607, Example 67 Cyclin-dependent kinase 7 Homo sapiens 1425 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795195&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492056 528826658 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 744314 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)C3(C#N)CC3)C2)ncc1F InChI=1S/C24H23F3N4O3/c1-34-20-10-18(26)17(25)8-16(20)15-9-21(29-11-19(15)27)31-22(32)13-3-2-4-14(7-13)30-23(33)24(12-28)5-6-24/h8-11,13-14H,2-7H2,1H3,(H,30,33)(H,29,31,32) FAUUOMXCICCIDU-UHFFFAOYSA-N 795195 US12570607, Example 67 Cyclin-dependent kinase 9 Homo sapiens 5.45 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795195&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492056 528826658 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1 744315 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H22F3N3O4/c1-31-18-8-16(23)15(22)6-14(18)13-7-19(25-9-17(13)24)27-21(30)11-3-2-4-12(5-11)26-20(29)10-28/h6-9,11-12,28H,2-5,10H2,1H3,(H,26,29)(H,25,27,30) GSLDYNPARRQUTQ-UHFFFAOYSA-N 795196 US12570607, Example 68 Cyclin-dependent kinase 1 Homo sapiens 73.6 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795196&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 156492046 528826659 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,11GY,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 744316 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H22F3N3O4/c1-31-18-8-16(23)15(22)6-14(18)13-7-19(25-9-17(13)24)27-21(30)11-3-2-4-12(5-11)26-20(29)10-28/h6-9,11-12,28H,2-5,10H2,1H3,(H,26,29)(H,25,27,30) GSLDYNPARRQUTQ-UHFFFAOYSA-N 795196 US12570607, Example 68 Cyclin-dependent kinase 2 Homo sapiens 274 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=796&target=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795196&enzyme=Cyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 156492046 528826659 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 23SR,9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9UGF,9UAW,9UAU,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 744317 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H22F3N3O4/c1-31-18-8-16(23)15(22)6-14(18)13-7-19(25-9-17(13)24)27-21(30)11-3-2-4-12(5-11)26-20(29)10-28/h6-9,11-12,28H,2-5,10H2,1H3,(H,26,29)(H,25,27,30) GSLDYNPARRQUTQ-UHFFFAOYSA-N 795196 US12570607, Example 68 Cyclin-dependent kinase 4 Homo sapiens 402 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795196&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 156492046 528826659 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 744318 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H22F3N3O4/c1-31-18-8-16(23)15(22)6-14(18)13-7-19(25-9-17(13)24)27-21(30)11-3-2-4-12(5-11)26-20(29)10-28/h6-9,11-12,28H,2-5,10H2,1H3,(H,26,29)(H,25,27,30) GSLDYNPARRQUTQ-UHFFFAOYSA-N 795196 US12570607, Example 68 Cyclin-dependent kinase 5 Homo sapiens 162 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=969&target=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795196&enzyme=Cyclin-dependent+kinase+5&column=ki&startPg=0&Increment=50&submit=Search 156492046 528826659 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 744319 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H22F3N3O4/c1-31-18-8-16(23)15(22)6-14(18)13-7-19(25-9-17(13)24)27-21(30)11-3-2-4-12(5-11)26-20(29)10-28/h6-9,11-12,28H,2-5,10H2,1H3,(H,26,29)(H,25,27,30) GSLDYNPARRQUTQ-UHFFFAOYSA-N 795196 US12570607, Example 68 Cyclin-dependent kinase 6 Homo sapiens 2034 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795196&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156492046 528826659 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,9D8U,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 744320 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H22F3N3O4/c1-31-18-8-16(23)15(22)6-14(18)13-7-19(25-9-17(13)24)27-21(30)11-3-2-4-12(5-11)26-20(29)10-28/h6-9,11-12,28H,2-5,10H2,1H3,(H,26,29)(H,25,27,30) GSLDYNPARRQUTQ-UHFFFAOYSA-N 795196 US12570607, Example 68 Cyclin-dependent kinase 7 Homo sapiens 2629 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795196&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492046 528826659 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,9QJN,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,9SKQ,9QCX,9QCV,9I9K,9I9J,9I9I,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 744321 COc1cc(F)c(F)cc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(=O)CO)C2)ncc1F InChI=1S/C21H22F3N3O4/c1-31-18-8-16(23)15(22)6-14(18)13-7-19(25-9-17(13)24)27-21(30)11-3-2-4-12(5-11)26-20(29)10-28/h6-9,11-12,28H,2-5,10H2,1H3,(H,26,29)(H,25,27,30) GSLDYNPARRQUTQ-UHFFFAOYSA-N 795196 US12570607, Example 68 Cyclin-dependent kinase 9 Homo sapiens 5.55 US Patent 10.7270/Q2HQ44VW aid1798248 US12570607 Wang, Z; Zhang, Y; Mu, Y; Guo, J; An, H; Gao, N; Zhang, C; Wang, J 3/10/2026 7/20/2026 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=795196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=997&target=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=795196&enzyme=Cyclin-dependent+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 156492046 528826659 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF 4EC9,4EC8,3MIA,3MI9,7NWK,6W9E,5L1Z,6CYT,4OGR,4IMY,4BCJ,4BCI,4BCH,4BCG,3TNI,3TNH,3TN8,3MY1,3LQ5,3BLR,3BLQ,3BLH,6GZH,4OR5,8K5R Cyclin-dependent kinase 9 CDK9_HUMAN P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1