BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1059822 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.088 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059823 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.348 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059824 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Serine/threonine-protein kinase pim-1 Homo sapiens 2.65 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=20&target=Serine%2Fthreonine-protein+kinase+pim-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Serine%2Fthreonine-protein+kinase+pim-1&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 4RPV,5TUR,9YKI,1XWS,6YKD,3BGZ,3BGQ,3BGP,2OBJ,4XHK,4JX7,4JX3,7ZUN,4BZO,4BZN,4ALW,4ALV,5DWR,4N70,4N6Z,4N6Y,3T9I,3DCV,3F2A,2XJ2,2XJ1,2XJ0,2XIZ,2XIY,2XIX,1XR1,1XQZ,3A99,4MTA,5V82,5V80,5DIA,5DHJ,5DGZ,5VUC,5VUB,5VUA,4LMU,4LM5,4LL5,4ENY,4ENX,3VC4,3VBY,3VBX,3VBW,3VBV,3VBT,3VBQ,3UMX,3UMW,3UIX,3R04,3R02,3R01,3R00,4A7C,7XSV,6L17,6L16,6L15,6L14,6L13,6L12,6L11,6KZI,5C1Q,4RC4,4RC3,4RC2,4RBL,4IAA,5KCX,4XH6,4MBL,4MBI,3JYA,3JY0,3JXW,2O65,2O64,2O63,2O3P,1YXX,1YXV,1YXU,1YXT,1YWV,4I41,5IIS,4K18,6BSK,5KGK,5KGI,5KGG,5KGE,5KGD,4DTK,6VRV,6VRU,5TEX,5TEL,4K0Y,6NO9,6NO8,4K1B,3C4E,1YI4,1YI3,1YHS,6MT0,5TOE,5KZI,5IPJ,5EOL,4WT6,4WSY,4WRS,4TY1,4AS0,3WE8 Serine/threonine-protein kinase pim-1 PIM1_HUMAN P11309 Q38RT9 Q5T7H7 Q96RG3 1059825 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Serine/threonine-protein kinase pim-2 Homo sapiens 5.68 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3422&target=Serine%2Fthreonine-protein+kinase+pim-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Serine%2Fthreonine-protein+kinase+pim-2&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP 4X7Q,2IWI Serine/threonine-protein kinase pim-2 PIM2_HUMAN Q9P1W9 A8K4G6 Q99739 1059826 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Serine/threonine-protein kinase pim-3 Homo sapiens 0.115 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5429&target=Serine%2Fthreonine-protein+kinase+pim-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Serine%2Fthreonine-protein+kinase+pim-3&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL Serine/threonine-protein kinase pim-3 PIM3_HUMAN Q86V86 A5D8X8 A8K7J0 B1B0P0 Q68BM2 1059829 CCc1c2c(nn1C)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C23H25N7O2/c1-5-20-15-7-9-19-16-12-14(6-8-18(16)25-26-19)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)27-29(20)3/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) OYRZNKOGWXPTBV-UHFFFAOYSA-N 796569 (17E)-16-ethyl-8,12,15-trimethyl- 2,11,12,15-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 7 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.247 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796569&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618755 528828032 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059830 CCc1c2c(nn1C)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C23H25N7O2/c1-5-20-15-7-9-19-16-12-14(6-8-18(16)25-26-19)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)27-29(20)3/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) OYRZNKOGWXPTBV-UHFFFAOYSA-N 796569 (17E)-16-ethyl-8,12,15-trimethyl- 2,11,12,15-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 7 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.537 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796569&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618755 528828032 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059831 CCc1c2c(nn1C)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C23H25N7O2/c1-5-20-15-7-9-19-16-12-14(6-8-18(16)25-26-19)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)27-29(20)3/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) OYRZNKOGWXPTBV-UHFFFAOYSA-N 796569 (17E)-16-ethyl-8,12,15-trimethyl- 2,11,12,15-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 7 Serine/threonine-protein kinase pim-1 Homo sapiens 6.72 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=20&target=Serine%2Fthreonine-protein+kinase+pim-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796569&enzyme=Serine%2Fthreonine-protein+kinase+pim-1&column=ki&startPg=0&Increment=50&submit=Search 170618755 528828032 1 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 4RPV,5TUR,9YKI,1XWS,6YKD,3BGZ,3BGQ,3BGP,2OBJ,4XHK,4JX7,4JX3,7ZUN,4BZO,4BZN,4ALW,4ALV,5DWR,4N70,4N6Z,4N6Y,3T9I,3DCV,3F2A,2XJ2,2XJ1,2XJ0,2XIZ,2XIY,2XIX,1XR1,1XQZ,3A99,4MTA,5V82,5V80,5DIA,5DHJ,5DGZ,5VUC,5VUB,5VUA,4LMU,4LM5,4LL5,4ENY,4ENX,3VC4,3VBY,3VBX,3VBW,3VBV,3VBT,3VBQ,3UMX,3UMW,3UIX,3R04,3R02,3R01,3R00,4A7C,7XSV,6L17,6L16,6L15,6L14,6L13,6L12,6L11,6KZI,5C1Q,4RC4,4RC3,4RC2,4RBL,4IAA,5KCX,4XH6,4MBL,4MBI,3JYA,3JY0,3JXW,2O65,2O64,2O63,2O3P,1YXX,1YXV,1YXU,1YXT,1YWV,4I41,5IIS,4K18,6BSK,5KGK,5KGI,5KGG,5KGE,5KGD,4DTK,6VRV,6VRU,5TEX,5TEL,4K0Y,6NO9,6NO8,4K1B,3C4E,1YI4,1YI3,1YHS,6MT0,5TOE,5KZI,5IPJ,5EOL,4WT6,4WSY,4WRS,4TY1,4AS0,3WE8 Serine/threonine-protein kinase pim-1 PIM1_HUMAN P11309 Q38RT9 Q5T7H7 Q96RG3 1059832 CCc1c2c(nn1C)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C23H25N7O2/c1-5-20-15-7-9-19-16-12-14(6-8-18(16)25-26-19)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)27-29(20)3/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) OYRZNKOGWXPTBV-UHFFFAOYSA-N 796569 (17E)-16-ethyl-8,12,15-trimethyl- 2,11,12,15-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 7 Serine/threonine-protein kinase pim-2 Homo sapiens 14.0 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3422&target=Serine%2Fthreonine-protein+kinase+pim-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796569&enzyme=Serine%2Fthreonine-protein+kinase+pim-2&column=ki&startPg=0&Increment=50&submit=Search 170618755 528828032 1 MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP 4X7Q,2IWI Serine/threonine-protein kinase pim-2 PIM2_HUMAN Q9P1W9 A8K4G6 Q99739 1059833 CCc1c2c(nn1C)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C23H25N7O2/c1-5-20-15-7-9-19-16-12-14(6-8-18(16)25-26-19)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)27-29(20)3/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) OYRZNKOGWXPTBV-UHFFFAOYSA-N 796569 (17E)-16-ethyl-8,12,15-trimethyl- 2,11,12,15-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 7 Serine/threonine-protein kinase pim-3 Homo sapiens 0.221 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5429&target=Serine%2Fthreonine-protein+kinase+pim-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796569&enzyme=Serine%2Fthreonine-protein+kinase+pim-3&column=ki&startPg=0&Increment=50&submit=Search 170618755 528828032 1 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL Serine/threonine-protein kinase pim-3 PIM3_HUMAN Q86V86 A5D8X8 A8K7J0 B1B0P0 Q68BM2 1059834 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C22H23N7O2/c1-13-15-6-8-19-16-11-14(5-7-18(16)24-25-19)17-12-23-29(4)22(17)31-10-9-27(2)21(30)20(15)28(3)26-13/h5-8,11-12H,9-10H2,1-4H3,(H,24,25) WBEJCAOCPUWZRI-UHFFFAOYSA-N 796570 (17E)-8,12,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 8 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.217 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796570&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618687 528828033 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059837 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C22H23N7O2/c1-13-15-6-8-19-16-11-14(5-7-18(16)24-25-19)17-12-23-29(4)22(17)31-10-9-27(2)21(30)20(15)28(3)26-13/h5-8,11-12H,9-10H2,1-4H3,(H,24,25) WBEJCAOCPUWZRI-UHFFFAOYSA-N 796570 (17E)-8,12,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 8 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.487 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796570&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618687 528828033 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059838 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C22H23N7O2/c1-13-15-6-8-19-16-11-14(5-7-18(16)24-25-19)17-12-23-29(4)22(17)31-10-9-27(2)21(30)20(15)28(3)26-13/h5-8,11-12H,9-10H2,1-4H3,(H,24,25) WBEJCAOCPUWZRI-UHFFFAOYSA-N 796570 (17E)-8,12,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 8 Serine/threonine-protein kinase pim-1 Homo sapiens 1.64 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=20&target=Serine%2Fthreonine-protein+kinase+pim-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796570&enzyme=Serine%2Fthreonine-protein+kinase+pim-1&column=ki&startPg=0&Increment=50&submit=Search 170618687 528828033 1 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 4RPV,5TUR,9YKI,1XWS,6YKD,3BGZ,3BGQ,3BGP,2OBJ,4XHK,4JX7,4JX3,7ZUN,4BZO,4BZN,4ALW,4ALV,5DWR,4N70,4N6Z,4N6Y,3T9I,3DCV,3F2A,2XJ2,2XJ1,2XJ0,2XIZ,2XIY,2XIX,1XR1,1XQZ,3A99,4MTA,5V82,5V80,5DIA,5DHJ,5DGZ,5VUC,5VUB,5VUA,4LMU,4LM5,4LL5,4ENY,4ENX,3VC4,3VBY,3VBX,3VBW,3VBV,3VBT,3VBQ,3UMX,3UMW,3UIX,3R04,3R02,3R01,3R00,4A7C,7XSV,6L17,6L16,6L15,6L14,6L13,6L12,6L11,6KZI,5C1Q,4RC4,4RC3,4RC2,4RBL,4IAA,5KCX,4XH6,4MBL,4MBI,3JYA,3JY0,3JXW,2O65,2O64,2O63,2O3P,1YXX,1YXV,1YXU,1YXT,1YWV,4I41,5IIS,4K18,6BSK,5KGK,5KGI,5KGG,5KGE,5KGD,4DTK,6VRV,6VRU,5TEX,5TEL,4K0Y,6NO9,6NO8,4K1B,3C4E,1YI4,1YI3,1YHS,6MT0,5TOE,5KZI,5IPJ,5EOL,4WT6,4WSY,4WRS,4TY1,4AS0,3WE8 Serine/threonine-protein kinase pim-1 PIM1_HUMAN P11309 Q38RT9 Q5T7H7 Q96RG3 1059841 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C22H23N7O2/c1-13-15-6-8-19-16-11-14(5-7-18(16)24-25-19)17-12-23-29(4)22(17)31-10-9-27(2)21(30)20(15)28(3)26-13/h5-8,11-12H,9-10H2,1-4H3,(H,24,25) WBEJCAOCPUWZRI-UHFFFAOYSA-N 796570 (17E)-8,12,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 8 Serine/threonine-protein kinase pim-2 Homo sapiens 8.17 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3422&target=Serine%2Fthreonine-protein+kinase+pim-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796570&enzyme=Serine%2Fthreonine-protein+kinase+pim-2&column=ki&startPg=0&Increment=50&submit=Search 170618687 528828033 1 MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP 4X7Q,2IWI Serine/threonine-protein kinase pim-2 PIM2_HUMAN Q9P1W9 A8K4G6 Q99739 1059842 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C22H23N7O2/c1-13-15-6-8-19-16-11-14(5-7-18(16)24-25-19)17-12-23-29(4)22(17)31-10-9-27(2)21(30)20(15)28(3)26-13/h5-8,11-12H,9-10H2,1-4H3,(H,24,25) WBEJCAOCPUWZRI-UHFFFAOYSA-N 796570 (17E)-8,12,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 8 Serine/threonine-protein kinase pim-3 Homo sapiens 0.073 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5429&target=Serine%2Fthreonine-protein+kinase+pim-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796570&enzyme=Serine%2Fthreonine-protein+kinase+pim-3&column=ki&startPg=0&Increment=50&submit=Search 170618687 528828033 1 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL Serine/threonine-protein kinase pim-3 PIM3_HUMAN Q86V86 A5D8X8 A8K7J0 B1B0P0 Q68BM2 1059843 Cc1c2c(nn1C)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C22H23N7O2/c1-13-15-6-8-19-16-11-14(5-7-18(16)24-25-19)17-12-23-29(4)22(17)31-10-9-27(2)21(30)20(15)26-28(13)3/h5-8,11-12H,9-10H2,1-4H3,(H,24,25) WFJUJQATCLMQFK-UHFFFAOYSA-N 796571 (17E)-8,12,15,16-tetramethyl- 2,11,12,15-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 9 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.347 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796571&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618727 528828034 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059844 Cc1c2c(nn1C)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C22H23N7O2/c1-13-15-6-8-19-16-11-14(5-7-18(16)24-25-19)17-12-23-29(4)22(17)31-10-9-27(2)21(30)20(15)26-28(13)3/h5-8,11-12H,9-10H2,1-4H3,(H,24,25) WFJUJQATCLMQFK-UHFFFAOYSA-N 796571 (17E)-8,12,15,16-tetramethyl- 2,11,12,15-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 9 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.592 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796571&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618727 528828034 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059847 Cc1c2c(nn1C)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C22H23N7O2/c1-13-15-6-8-19-16-11-14(5-7-18(16)24-25-19)17-12-23-29(4)22(17)31-10-9-27(2)21(30)20(15)26-28(13)3/h5-8,11-12H,9-10H2,1-4H3,(H,24,25) WFJUJQATCLMQFK-UHFFFAOYSA-N 796571 (17E)-8,12,15,16-tetramethyl- 2,11,12,15-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 9 Serine/threonine-protein kinase pim-1 Homo sapiens 12.7 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=20&target=Serine%2Fthreonine-protein+kinase+pim-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796571&enzyme=Serine%2Fthreonine-protein+kinase+pim-1&column=ki&startPg=0&Increment=50&submit=Search 170618727 528828034 1 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 4RPV,5TUR,9YKI,1XWS,6YKD,3BGZ,3BGQ,3BGP,2OBJ,4XHK,4JX7,4JX3,7ZUN,4BZO,4BZN,4ALW,4ALV,5DWR,4N70,4N6Z,4N6Y,3T9I,3DCV,3F2A,2XJ2,2XJ1,2XJ0,2XIZ,2XIY,2XIX,1XR1,1XQZ,3A99,4MTA,5V82,5V80,5DIA,5DHJ,5DGZ,5VUC,5VUB,5VUA,4LMU,4LM5,4LL5,4ENY,4ENX,3VC4,3VBY,3VBX,3VBW,3VBV,3VBT,3VBQ,3UMX,3UMW,3UIX,3R04,3R02,3R01,3R00,4A7C,7XSV,6L17,6L16,6L15,6L14,6L13,6L12,6L11,6KZI,5C1Q,4RC4,4RC3,4RC2,4RBL,4IAA,5KCX,4XH6,4MBL,4MBI,3JYA,3JY0,3JXW,2O65,2O64,2O63,2O3P,1YXX,1YXV,1YXU,1YXT,1YWV,4I41,5IIS,4K18,6BSK,5KGK,5KGI,5KGG,5KGE,5KGD,4DTK,6VRV,6VRU,5TEX,5TEL,4K0Y,6NO9,6NO8,4K1B,3C4E,1YI4,1YI3,1YHS,6MT0,5TOE,5KZI,5IPJ,5EOL,4WT6,4WSY,4WRS,4TY1,4AS0,3WE8 Serine/threonine-protein kinase pim-1 PIM1_HUMAN P11309 Q38RT9 Q5T7H7 Q96RG3 1059848 Cc1c2c(nn1C)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C22H23N7O2/c1-13-15-6-8-19-16-11-14(5-7-18(16)24-25-19)17-12-23-29(4)22(17)31-10-9-27(2)21(30)20(15)26-28(13)3/h5-8,11-12H,9-10H2,1-4H3,(H,24,25) WFJUJQATCLMQFK-UHFFFAOYSA-N 796571 (17E)-8,12,15,16-tetramethyl- 2,11,12,15-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 9 Serine/threonine-protein kinase pim-2 Homo sapiens 145 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3422&target=Serine%2Fthreonine-protein+kinase+pim-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796571&enzyme=Serine%2Fthreonine-protein+kinase+pim-2&column=ki&startPg=0&Increment=50&submit=Search 170618727 528828034 1 MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP 4X7Q,2IWI Serine/threonine-protein kinase pim-2 PIM2_HUMAN Q9P1W9 A8K4G6 Q99739 1059849 Cc1c2c(nn1C)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C22H23N7O2/c1-13-15-6-8-19-16-11-14(5-7-18(16)24-25-19)17-12-23-29(4)22(17)31-10-9-27(2)21(30)20(15)26-28(13)3/h5-8,11-12H,9-10H2,1-4H3,(H,24,25) WFJUJQATCLMQFK-UHFFFAOYSA-N 796571 (17E)-8,12,15,16-tetramethyl- 2,11,12,15-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 9 Serine/threonine-protein kinase pim-3 Homo sapiens 3.65 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5429&target=Serine%2Fthreonine-protein+kinase+pim-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796571&enzyme=Serine%2Fthreonine-protein+kinase+pim-3&column=ki&startPg=0&Increment=50&submit=Search 170618727 528828034 1 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL Serine/threonine-protein kinase pim-3 PIM3_HUMAN Q86V86 A5D8X8 A8K7J0 B1B0P0 Q68BM2 1059850 CCn1nc(C)c2c1C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C23H25N7O2/c1-5-30-21-16(14(2)27-30)7-9-20-17-12-15(6-8-19(17)25-26-20)18-13-24-29(4)23(18)32-11-10-28(3)22(21)31/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) KEFWAZLNECJOKH-UHFFFAOYSA-N 796572 (17E)-14-ethyl-8,12,16-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 11 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.084 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796572 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796572&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618734 528828035 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059851 CCn1nc(C)c2c1C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C23H25N7O2/c1-5-30-21-16(14(2)27-30)7-9-20-17-12-15(6-8-19(17)25-26-20)18-13-24-29(4)23(18)32-11-10-28(3)22(21)31/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) KEFWAZLNECJOKH-UHFFFAOYSA-N 796572 (17E)-14-ethyl-8,12,16-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 11 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.566 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796572 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796572&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618734 528828035 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059854 Cc1c2c(nn1CCN1CCCC1)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C27H32N8O2/c1-18-20-7-9-24-21-16-19(6-8-23(21)29-30-24)22-17-28-33(3)27(22)37-15-14-32(2)26(36)25(20)31-35(18)13-12-34-10-4-5-11-34/h6-9,16-17H,4-5,10-15H2,1-3H3,(H,29,30) CJRZMGVXKCHUPF-UHFFFAOYSA-N 796573 (17E)-8,12,16-trimethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,11,12,15- tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 19 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.564 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796573&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618697 528828036 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059855 Cc1c2c(nn1CCN1CCCC1)C(=O)N(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 InChI=1S/C27H32N8O2/c1-18-20-7-9-24-21-16-19(6-8-23(21)29-30-24)22-17-28-33(3)27(22)37-15-14-32(2)26(36)25(20)31-35(18)13-12-34-10-4-5-11-34/h6-9,16-17H,4-5,10-15H2,1-3H3,(H,29,30) CJRZMGVXKCHUPF-UHFFFAOYSA-N 796573 (17E)-8,12,16-trimethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,11,12,15- tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 19 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 1.05 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796573&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618697 528828036 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059856 Cc1nn(C(C)C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C24H27N7O2/c1-14(2)31-22-17(15(3)28-31)7-9-21-18-12-16(6-8-20(18)26-27-21)19-13-25-30(5)24(19)33-11-10-29(4)23(22)32/h6-9,12-14H,10-11H2,1-5H3,(H,26,27) MDSMWABOKGAJOL-UHFFFAOYSA-N 796574 (17E)-8,12,16-trimethyl-14-(propan-2- yl)-2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 20 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.187 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796574&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170443360 528828037 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059857 Cc1nn(C(C)C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C24H27N7O2/c1-14(2)31-22-17(15(3)28-31)7-9-21-18-12-16(6-8-20(18)26-27-21)19-13-25-30(5)24(19)33-11-10-29(4)23(22)32/h6-9,12-14H,10-11H2,1-5H3,(H,26,27) MDSMWABOKGAJOL-UHFFFAOYSA-N 796574 (17E)-8,12,16-trimethyl-14-(propan-2- yl)-2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 20 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.775 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796574&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170443360 528828037 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059860 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O3/c1-5-32-21-15-7-9-19-16-12-14(6-8-18(16)25-26-19)17-13-24-30(4)23(17)33-11-10-28(2)22(31)20(15)29(3)27-21/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) JOUBNAIELHYNLN-UHFFFAOYSA-N 796575 (17E)-16-ethoxy-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 22 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.093 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796575&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170444341 528828038 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059861 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O3/c1-5-32-21-15-7-9-19-16-12-14(6-8-18(16)25-26-19)17-13-24-30(4)23(17)33-11-10-28(2)22(31)20(15)29(3)27-21/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) JOUBNAIELHYNLN-UHFFFAOYSA-N 796575 (17E)-16-ethoxy-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 22 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.527 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796575&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170444341 528828038 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059864 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2=O InChI=1S/C24H27N7O2/c1-6-19-16-8-10-21-17-11-15(7-9-20(17)26-27-21)18-12-25-31(5)24(18)33-14(2)13-29(3)23(32)22(16)30(4)28-19/h7-12,14H,6,13H2,1-5H3,(H,26,27) HXVRKGLAPIGEOY-UHFFFAOYSA-N 796576 (10S,17E)-16-ethyl-8,10,12,14- tetramethyl-2,11,12,14-tetrahydro-8H- 3,5-ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 23 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.416 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796576&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170444342 528828039 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059867 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2=O InChI=1S/C24H27N7O2/c1-6-19-16-8-10-21-17-11-15(7-9-20(17)26-27-21)18-12-25-31(5)24(18)33-14(2)13-29(3)23(32)22(16)30(4)28-19/h7-12,14H,6,13H2,1-5H3,(H,26,27) HXVRKGLAPIGEOY-UHFFFAOYSA-N 796576 (10S,17E)-16-ethyl-8,10,12,14- tetramethyl-2,11,12,14-tetrahydro-8H- 3,5-ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 23 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.967 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796576&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170444342 528828039 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059870 CN1CCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)/C=C/c2c(C#N)cn(C)c2C1=O InChI=1S/C23H21N7O2/c1-28-8-9-32-23-18(12-25-30(23)3)14-4-6-19-17(10-14)20(27-26-19)7-5-16-15(11-24)13-29(2)21(16)22(28)31/h4-7,10,12-13H,8-9H2,1-3H3,(H,26,27) YHMMGPOWQBHFQF-UHFFFAOYSA-N 796577 (17E)-8,12,14-trimethyl-13-oxo- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20260070924, Example 24 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.230 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796577&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178423325 528828040 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059873 CN1CCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)/C=C/c2c(C#N)cn(C)c2C1=O InChI=1S/C23H21N7O2/c1-28-8-9-32-23-18(12-25-30(23)3)14-4-6-19-17(10-14)20(27-26-19)7-5-16-15(11-24)13-29(2)21(16)22(28)31/h4-7,10,12-13H,8-9H2,1-3H3,(H,26,27) YHMMGPOWQBHFQF-UHFFFAOYSA-N 796577 (17E)-8,12,14-trimethyl-13-oxo- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20260070924, Example 24 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.475 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796577&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178423325 528828040 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059876 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 0.180 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059879 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Receptor-type tyrosine-protein kinase FLT3 [D835H] Homo sapiens 67.0 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=545&target=Receptor-type+tyrosine-protein+kinase+FLT3+%5BD835H%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3+%5BD835H%5D&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARHIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7 Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059882 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Receptor-type tyrosine-protein kinase FLT3 [D835V] Homo sapiens 0.062 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1349&target=Receptor-type+tyrosine-protein+kinase+FLT3+%5BD835V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3+%5BD835V%5D&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARVIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7 Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059885 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Receptor-type tyrosine-protein kinase FLT3 [D835Y] Homo sapiens 4.10 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=548&target=Receptor-type+tyrosine-protein+kinase+FLT3+%5BD835Y%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3+%5BD835Y%5D&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARYIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7 Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059888 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 6.30 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059889 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Dimer of Receptor-type tyrosine-protein kinase FLT3 [D835V] Homo sapiens 0.058 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=360&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3+%5BD835V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3+%5BD835V%5D&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARVIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7 Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059890 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Dimer of Receptor-type tyrosine-protein kinase FLT3 [F691L] Homo sapiens 0.230 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=359&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3+%5BF691L%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3+%5BF691L%5D&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLILEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7 Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059891 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Receptor-type tyrosine-protein kinase FLT3 [K663Q] Homo sapiens 16.0 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10824&target=Receptor-type+tyrosine-protein+kinase+FLT3+%5BK663Q%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3+%5BK663Q%5D&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELQMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7 Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059894 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Receptor-type tyrosine-protein kinase FLT3 [N841I] Homo sapiens 2.20 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4175&target=Receptor-type+tyrosine-protein+kinase+FLT3+%5BN841I%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3+%5BN841I%5D&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSIYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7 Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059895 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Receptor-type tyrosine-protein kinase FLT3 [R834Q] Homo sapiens 0.890 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10826&target=Receptor-type+tyrosine-protein+kinase+FLT3+%5BR834Q%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3+%5BR834Q%5D&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLAQDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7 Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059898 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Dimer of Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 9.10 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=218&target=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Dimer+of+Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 1059899 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Dual specificity protein kinase CLK1 Homo sapiens 0.134 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1059900 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Dual specificity protein kinase CLK2 Homo sapiens 0.165 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1059901 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Dual specificity protein kinase CLK3 Homo sapiens 5.87 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7735&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1059902 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O2/c1-5-18-15-7-9-20-16-12-14(6-8-19(16)25-26-20)17-13-24-30(4)23(17)32-11-10-28(2)22(31)21(15)29(3)27-18/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) WUJPNDFKWVGKPZ-UHFFFAOYSA-N 796568 (17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 6 Dual specificity protein kinase CLK4 Homo sapiens 0.446 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796568&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 170618742 528828031 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1059903 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCN(C)C2=O InChI=1S/C24H28N8O/c1-15-17-7-9-21-18-12-16(6-8-20(18)26-27-21)19-13-25-31(4)22(19)14-29(2)10-11-30(3)24(33)23(17)32(5)28-15/h6-9,12-13H,10-11,14H2,1-5H3,(H,26,27) SHBPRUJLRWUITB-UHFFFAOYSA-N 796578 (18E)-8,10,13,15,17-pentamethyl- 2,8,9,10,11,12,13,15-octahydro-14H- 3,5-ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]diazacyclohexadecin-14-one::US20260070924, Example 15 Dual specificity protein kinase CLK1 Homo sapiens 0.157 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796578&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 170618730 528828041 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1059906 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCN(C)C2=O InChI=1S/C24H28N8O/c1-15-17-7-9-21-18-12-16(6-8-20(18)26-27-21)19-13-25-31(4)22(19)14-29(2)10-11-30(3)24(33)23(17)32(5)28-15/h6-9,12-13H,10-11,14H2,1-5H3,(H,26,27) SHBPRUJLRWUITB-UHFFFAOYSA-N 796578 (18E)-8,10,13,15,17-pentamethyl- 2,8,9,10,11,12,13,15-octahydro-14H- 3,5-ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]diazacyclohexadecin-14-one::US20260070924, Example 15 Dual specificity protein kinase CLK2 Homo sapiens 0.161 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796578&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 170618730 528828041 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1059907 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCN(C)C2=O InChI=1S/C24H28N8O/c1-15-17-7-9-21-18-12-16(6-8-20(18)26-27-21)19-13-25-31(4)22(19)14-29(2)10-11-30(3)24(33)23(17)32(5)28-15/h6-9,12-13H,10-11,14H2,1-5H3,(H,26,27) SHBPRUJLRWUITB-UHFFFAOYSA-N 796578 (18E)-8,10,13,15,17-pentamethyl- 2,8,9,10,11,12,13,15-octahydro-14H- 3,5-ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]diazacyclohexadecin-14-one::US20260070924, Example 15 Dual specificity protein kinase CLK3 Homo sapiens 2.77 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7735&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796578&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 170618730 528828041 1 MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1059908 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCN(C)C2=O InChI=1S/C24H28N8O/c1-15-17-7-9-21-18-12-16(6-8-20(18)26-27-21)19-13-25-31(4)22(19)14-29(2)10-11-30(3)24(33)23(17)32(5)28-15/h6-9,12-13H,10-11,14H2,1-5H3,(H,26,27) SHBPRUJLRWUITB-UHFFFAOYSA-N 796578 (18E)-8,10,13,15,17-pentamethyl- 2,8,9,10,11,12,13,15-octahydro-14H- 3,5-ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]diazacyclohexadecin-14-one::US20260070924, Example 15 Dual specificity protein kinase CLK4 Homo sapiens 0.530 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796578&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 170618730 528828041 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1059909 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O3/c1-14-16-5-7-20-17-12-15(4-6-19(17)25-26-20)18-13-24-29(3)23(18)33-11-9-28(2)22(32)21(16)30(27-14)8-10-31/h4-7,12-13,31H,8-11H2,1-3H3,(H,25,26) CQHNEHSGCWTBBT-UHFFFAOYSA-N 796579 (17E)-14-(2-hydroxyethyl)-8,12,16- trimethyl-2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 16 Dual specificity protein kinase CLK1 Homo sapiens 0.299 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796579&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 170443353 528828042 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1059910 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O3/c1-14-16-5-7-20-17-12-15(4-6-19(17)25-26-20)18-13-24-29(3)23(18)33-11-9-28(2)22(32)21(16)30(27-14)8-10-31/h4-7,12-13,31H,8-11H2,1-3H3,(H,25,26) CQHNEHSGCWTBBT-UHFFFAOYSA-N 796579 (17E)-14-(2-hydroxyethyl)-8,12,16- trimethyl-2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 16 Dual specificity protein kinase CLK2 Homo sapiens 0.160 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796579&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 170443353 528828042 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1059911 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O3/c1-14-16-5-7-20-17-12-15(4-6-19(17)25-26-20)18-13-24-29(3)23(18)33-11-9-28(2)22(32)21(16)30(27-14)8-10-31/h4-7,12-13,31H,8-11H2,1-3H3,(H,25,26) CQHNEHSGCWTBBT-UHFFFAOYSA-N 796579 (17E)-14-(2-hydroxyethyl)-8,12,16- trimethyl-2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 16 Dual specificity protein kinase CLK3 Homo sapiens 10.4 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7735&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796579&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 170443353 528828042 1 MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1059912 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O3/c1-14-16-5-7-20-17-12-15(4-6-19(17)25-26-20)18-13-24-29(3)23(18)33-11-9-28(2)22(32)21(16)30(27-14)8-10-31/h4-7,12-13,31H,8-11H2,1-3H3,(H,25,26) CQHNEHSGCWTBBT-UHFFFAOYSA-N 796579 (17E)-14-(2-hydroxyethyl)-8,12,16- trimethyl-2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 16 Dual specificity protein kinase CLK4 Homo sapiens 0.758 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796579&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 170443353 528828042 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1059913 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O3/c1-5-32-21-15-7-9-19-16-12-14(6-8-18(16)25-26-19)17-13-24-30(4)23(17)33-11-10-28(2)22(31)20(15)29(3)27-21/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) JOUBNAIELHYNLN-UHFFFAOYSA-N 796575 (17E)-16-ethoxy-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 22 Dual specificity protein kinase CLK1 Homo sapiens 0.355 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796575&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 170444341 528828038 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1059916 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O3/c1-5-32-21-15-7-9-19-16-12-14(6-8-18(16)25-26-19)17-13-24-30(4)23(17)33-11-10-28(2)22(31)20(15)29(3)27-21/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) JOUBNAIELHYNLN-UHFFFAOYSA-N 796575 (17E)-16-ethoxy-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 22 Dual specificity protein kinase CLK2 Homo sapiens 0.253 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796575&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 170444341 528828038 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1059917 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O3/c1-5-32-21-15-7-9-19-16-12-14(6-8-18(16)25-26-19)17-13-24-30(4)23(17)33-11-10-28(2)22(31)20(15)29(3)27-21/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) JOUBNAIELHYNLN-UHFFFAOYSA-N 796575 (17E)-16-ethoxy-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 22 Dual specificity protein kinase CLK3 Homo sapiens 9.47 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7735&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796575&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 170444341 528828038 1 MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1059918 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C23H25N7O3/c1-5-32-21-15-7-9-19-16-12-14(6-8-18(16)25-26-19)17-13-24-30(4)23(17)33-11-10-28(2)22(31)20(15)29(3)27-21/h6-9,12-13H,5,10-11H2,1-4H3,(H,25,26) JOUBNAIELHYNLN-UHFFFAOYSA-N 796575 (17E)-16-ethoxy-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 22 Dual specificity protein kinase CLK4 Homo sapiens 0.668 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796575&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 170444341 528828038 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1059919 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2=O InChI=1S/C24H27N7O2/c1-6-19-16-8-10-21-17-11-15(7-9-20(17)26-27-21)18-12-25-31(5)24(18)33-14(2)13-29(3)23(32)22(16)30(4)28-19/h7-12,14H,6,13H2,1-5H3,(H,26,27) HXVRKGLAPIGEOY-UHFFFAOYSA-N 796576 (10S,17E)-16-ethyl-8,10,12,14- tetramethyl-2,11,12,14-tetrahydro-8H- 3,5-ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 23 Dual specificity protein kinase CLK1 Homo sapiens 0.843 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796576&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 170444342 528828039 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1059920 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2=O InChI=1S/C24H27N7O2/c1-6-19-16-8-10-21-17-11-15(7-9-20(17)26-27-21)18-12-25-31(5)24(18)33-14(2)13-29(3)23(32)22(16)30(4)28-19/h7-12,14H,6,13H2,1-5H3,(H,26,27) HXVRKGLAPIGEOY-UHFFFAOYSA-N 796576 (10S,17E)-16-ethyl-8,10,12,14- tetramethyl-2,11,12,14-tetrahydro-8H- 3,5-ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 23 Dual specificity protein kinase CLK2 Homo sapiens 0.225 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796576&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 170444342 528828039 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1059921 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2=O InChI=1S/C24H27N7O2/c1-6-19-16-8-10-21-17-11-15(7-9-20(17)26-27-21)18-12-25-31(5)24(18)33-14(2)13-29(3)23(32)22(16)30(4)28-19/h7-12,14H,6,13H2,1-5H3,(H,26,27) HXVRKGLAPIGEOY-UHFFFAOYSA-N 796576 (10S,17E)-16-ethyl-8,10,12,14- tetramethyl-2,11,12,14-tetrahydro-8H- 3,5-ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 23 Dual specificity protein kinase CLK3 Homo sapiens 5.53 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7735&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796576&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 170444342 528828039 1 MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1059922 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2=O InChI=1S/C24H27N7O2/c1-6-19-16-8-10-21-17-11-15(7-9-20(17)26-27-21)18-12-25-31(5)24(18)33-14(2)13-29(3)23(32)22(16)30(4)28-19/h7-12,14H,6,13H2,1-5H3,(H,26,27) HXVRKGLAPIGEOY-UHFFFAOYSA-N 796576 (10S,17E)-16-ethyl-8,10,12,14- tetramethyl-2,11,12,14-tetrahydro-8H- 3,5-ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-13(10H)- one::US20260070924, Example 23 Dual specificity protein kinase CLK4 Homo sapiens 1.39 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796576&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 170444342 528828039 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1059923 CN1CCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)/C=C/c2c(C#N)cn(C)c2C1=O InChI=1S/C23H21N7O2/c1-28-8-9-32-23-18(12-25-30(23)3)14-4-6-19-17(10-14)20(27-26-19)7-5-16-15(11-24)13-29(2)21(16)22(28)31/h4-7,10,12-13H,8-9H2,1-3H3,(H,26,27) YHMMGPOWQBHFQF-UHFFFAOYSA-N 796577 (17E)-8,12,14-trimethyl-13-oxo- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20260070924, Example 24 Dual specificity protein kinase CLK1 Homo sapiens 0.415 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796577&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 178423325 528828040 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1059924 CN1CCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)/C=C/c2c(C#N)cn(C)c2C1=O InChI=1S/C23H21N7O2/c1-28-8-9-32-23-18(12-25-30(23)3)14-4-6-19-17(10-14)20(27-26-19)7-5-16-15(11-24)13-29(2)21(16)22(28)31/h4-7,10,12-13H,8-9H2,1-3H3,(H,26,27) YHMMGPOWQBHFQF-UHFFFAOYSA-N 796577 (17E)-8,12,14-trimethyl-13-oxo- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20260070924, Example 24 Dual specificity protein kinase CLK2 Homo sapiens 0.670 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796577&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 178423325 528828040 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1059925 CN1CCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)/C=C/c2c(C#N)cn(C)c2C1=O InChI=1S/C23H21N7O2/c1-28-8-9-32-23-18(12-25-30(23)3)14-4-6-19-17(10-14)20(27-26-19)7-5-16-15(11-24)13-29(2)21(16)22(28)31/h4-7,10,12-13H,8-9H2,1-3H3,(H,26,27) YHMMGPOWQBHFQF-UHFFFAOYSA-N 796577 (17E)-8,12,14-trimethyl-13-oxo- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20260070924, Example 24 Dual specificity protein kinase CLK3 Homo sapiens 92.9 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7735&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796577&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 178423325 528828040 1 MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1059928 CN1CCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)/C=C/c2c(C#N)cn(C)c2C1=O InChI=1S/C23H21N7O2/c1-28-8-9-32-23-18(12-25-30(23)3)14-4-6-19-17(10-14)20(27-26-19)7-5-16-15(11-24)13-29(2)21(16)22(28)31/h4-7,10,12-13H,8-9H2,1-3H3,(H,26,27) YHMMGPOWQBHFQF-UHFFFAOYSA-N 796577 (17E)-8,12,14-trimethyl-13-oxo- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20260070924, Example 24 Dual specificity protein kinase CLK4 Homo sapiens 0.593 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796577&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 178423325 528828040 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1059929 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CN(C)C2=O InChI=1S/C24H28N8O2/c1-15-17-6-8-21-18-11-16(5-7-20(18)26-27-21)19-12-25-31(4)22(19)13-29(2)14-30(3)24(34)23(17)32(28-15)9-10-33/h5-8,11-12,33H,9-10,13-14H2,1-4H3,(H,26,27) ZSHXYVXQVAHPIZ-UHFFFAOYSA-N 796580 (18E)-15-(2-hydroxyethyl)-8,10,13,17- tetramethyl-2,8,9,10,11,12,13,15- octahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]diazacyclohexadecin-14-one::US20260070924, Example 26 Dual specificity protein kinase CLK1 Homo sapiens 0.233 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796580&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 178423326 528828043 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1059932 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CN(C)C2=O InChI=1S/C24H28N8O2/c1-15-17-6-8-21-18-11-16(5-7-20(18)26-27-21)19-12-25-31(4)22(19)13-29(2)14-30(3)24(34)23(17)32(28-15)9-10-33/h5-8,11-12,33H,9-10,13-14H2,1-4H3,(H,26,27) ZSHXYVXQVAHPIZ-UHFFFAOYSA-N 796580 (18E)-15-(2-hydroxyethyl)-8,10,13,17- tetramethyl-2,8,9,10,11,12,13,15- octahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]diazacyclohexadecin-14-one::US20260070924, Example 26 Dual specificity protein kinase CLK2 Homo sapiens 0.386 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796580&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 178423326 528828043 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1059935 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CN(C)C2=O InChI=1S/C24H28N8O2/c1-15-17-6-8-21-18-11-16(5-7-20(18)26-27-21)19-12-25-31(4)22(19)13-29(2)14-30(3)24(34)23(17)32(28-15)9-10-33/h5-8,11-12,33H,9-10,13-14H2,1-4H3,(H,26,27) ZSHXYVXQVAHPIZ-UHFFFAOYSA-N 796580 (18E)-15-(2-hydroxyethyl)-8,10,13,17- tetramethyl-2,8,9,10,11,12,13,15- octahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]diazacyclohexadecin-14-one::US20260070924, Example 26 Dual specificity protein kinase CLK3 Homo sapiens 31.1 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7735&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796580&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 178423326 528828043 1 MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1059936 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CN(C)C2=O InChI=1S/C24H28N8O2/c1-15-17-6-8-21-18-11-16(5-7-20(18)26-27-21)19-12-25-31(4)22(19)13-29(2)14-30(3)24(34)23(17)32(28-15)9-10-33/h5-8,11-12,33H,9-10,13-14H2,1-4H3,(H,26,27) ZSHXYVXQVAHPIZ-UHFFFAOYSA-N 796580 (18E)-15-(2-hydroxyethyl)-8,10,13,17- tetramethyl-2,8,9,10,11,12,13,15- octahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]diazacyclohexadecin-14-one::US20260070924, Example 26 Dual specificity protein kinase CLK4 Homo sapiens 0.605 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796580&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 178423326 528828043 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1059939 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C24H27N7O4/c1-4-34-22-16-6-8-20-17-13-15(5-7-19(17)26-27-20)18-14-25-30(3)24(18)35-12-10-29(2)23(33)21(16)31(28-22)9-11-32/h5-8,13-14,32H,4,9-12H2,1-3H3,(H,26,27) RCZKZELXIOZBST-UHFFFAOYSA-N 796581 (17E)-16-ethoxy-14-(2-hydroxyethyl)- 8,12-dimethyl-2,11,12,14-tetrahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3'-n][1,4]oxazacyclopentadecin- 13(10H)-one::US20260070924, Example 27 Dual specificity protein kinase CLK1 Homo sapiens 1.55 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796581&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 170443364 528828044 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1059942 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C24H27N7O4/c1-4-34-22-16-6-8-20-17-13-15(5-7-19(17)26-27-20)18-14-25-30(3)24(18)35-12-10-29(2)23(33)21(16)31(28-22)9-11-32/h5-8,13-14,32H,4,9-12H2,1-3H3,(H,26,27) RCZKZELXIOZBST-UHFFFAOYSA-N 796581 (17E)-16-ethoxy-14-(2-hydroxyethyl)- 8,12-dimethyl-2,11,12,14-tetrahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3'-n][1,4]oxazacyclopentadecin- 13(10H)-one::US20260070924, Example 27 Dual specificity protein kinase CLK2 Homo sapiens 1.11 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796581&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 170443364 528828044 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1059945 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C24H27N7O4/c1-4-34-22-16-6-8-20-17-13-15(5-7-19(17)26-27-20)18-14-25-30(3)24(18)35-12-10-29(2)23(33)21(16)31(28-22)9-11-32/h5-8,13-14,32H,4,9-12H2,1-3H3,(H,26,27) RCZKZELXIOZBST-UHFFFAOYSA-N 796581 (17E)-16-ethoxy-14-(2-hydroxyethyl)- 8,12-dimethyl-2,11,12,14-tetrahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3'-n][1,4]oxazacyclopentadecin- 13(10H)-one::US20260070924, Example 27 Dual specificity protein kinase CLK3 Homo sapiens 108 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7735&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796581&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 170443364 528828044 1 MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1059948 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2=O InChI=1S/C24H27N7O4/c1-4-34-22-16-6-8-20-17-13-15(5-7-19(17)26-27-20)18-14-25-30(3)24(18)35-12-10-29(2)23(33)21(16)31(28-22)9-11-32/h5-8,13-14,32H,4,9-12H2,1-3H3,(H,26,27) RCZKZELXIOZBST-UHFFFAOYSA-N 796581 (17E)-16-ethoxy-14-(2-hydroxyethyl)- 8,12-dimethyl-2,11,12,14-tetrahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3'-n][1,4]oxazacyclopentadecin- 13(10H)-one::US20260070924, Example 27 Dual specificity protein kinase CLK4 Homo sapiens 3.03 US Patent 10.7270/Q29Z99WV aid1805688 US20260070924 CUI, JJ; RUI, EY; ROGERS, EW; UNG, J; JIANG, P; ZHAI, D; DENG, W 3/12/2026 7/23/2026 Blossomhill Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796581&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 170443364 528828044 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1