BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1059951 Cn1nc2cccc3c2c1CCCNC(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C33H28F2N8O2/c1-41-28-9-4-12-36-33(44)29-15-22(45-21-6-2-5-19(13-21)23-7-3-8-26(40-41)30(23)28)17-42(29)31-24-16-39-43(32(24)38-18-37-31)27-11-10-20(34)14-25(27)35/h2-3,5-8,10-11,13-14,16,18,22,29H,4,9,12,15,17H2,1H3,(H,36,44) BVAVPXARFZCVRV-UHFFFAOYSA-N 796582 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 1 Stimulator of interferon genes protein [139-379] Homo sapiens 0.800 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796582&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170443954 528828045 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059952 CN1CCCc2c3c(cccc3nn2C)-c2cccc(c2)O[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C34H30F2N8O2/c1-41-13-5-10-29-31-24(8-4-9-27(31)40-42(29)2)20-6-3-7-22(14-20)46-23-16-30(34(41)45)43(18-23)32-25-17-39-44(33(25)38-19-37-32)28-12-11-21(35)15-26(28)36/h3-4,6-9,11-12,14-15,17,19,23,30H,5,10,13,16,18H2,1-2H3 FJCBTPXWIHEFBT-UHFFFAOYSA-N 796583 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 2 Stimulator of interferon genes protein [139-379] Homo sapiens 2.70 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796583&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444015 528828046 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059953 CN1CCCc2c3c(cccc3nn2C)-c2cccc(n2)N[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C33H30F2N10O/c1-42-13-5-9-27-30-21(6-3-8-25(30)41-43(27)2)24-7-4-10-29(40-24)39-20-15-28(33(42)46)44(17-20)31-22-16-38-45(32(22)37-18-36-31)26-12-11-19(34)14-23(26)35/h3-4,6-8,10-12,14,16,18,20,28H,5,9,13,15,17H2,1-2H3,(H,39,40) ILQIHYOODVRKTD-UHFFFAOYSA-N 796584 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-7,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 3 Stimulator of interferon genes protein [139-379] Homo sapiens 0.600 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796584 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796584&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611454 528828047 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059956 CN1CCCc2c3c(cccc3nn2C)-c2ccnc(n2)N[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C32H29F2N11O/c1-42-12-4-7-26-28-20(5-3-6-24(28)41-43(26)2)23-10-11-35-32(40-23)39-19-14-27(31(42)46)44(16-19)29-21-15-38-45(30(21)37-17-36-29)25-9-8-18(33)13-22(25)34/h3,5-6,8-11,13,15,17,19,27H,4,7,12,14,16H2,1-2H3,(H,35,39,40) NCXYDLUSXUZQAG-UHFFFAOYSA-N 796585 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-5,7,10,13,18,19,26-heptazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2,4,6(26),17::US20260070927, Example 4 Stimulator of interferon genes protein [139-379] Homo sapiens 0.500 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796585 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796585&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444062 528828048 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059959 CN1CCCc2c3c(cccc3nn2C)-c2ccnc(n2)N[C@H]2C[C@@H](C1=O)N(c1nccn3c(-c4ccc(F)cc4F)ncc13)C2 InChI=1S/C33H30F2N10O/c1-42-13-4-7-26-29-22(5-3-6-25(29)41-43(26)2)24-10-11-37-33(40-24)39-20-16-27(32(42)46)45(18-20)31-28-17-38-30(44(28)14-12-36-31)21-9-8-19(34)15-23(21)35/h3,5-6,8-12,14-15,17,20,27H,4,7,13,16,18H2,1-2H3,(H,37,39,40) SZOCDIXFGABGQA-UHFFFAOYSA-N 796586 (8S,11S)-10-[3-(2,4-difluorophenyl)imidazo[1,5-a]pyrazin-8-yl]-13,18-dimethyl-5,7,10,13,18,19,26-heptazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2,4,6(26),17::US20260070927, Example 5 Stimulator of interferon genes protein [139-379] Homo sapiens 3.80 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796586 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796586&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611421 528828049 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059962 COc1cc(F)ccc1-n1ncc2c(N3C[C@@H]4C[C@H]3C(=O)N(C)CCCc3c5c(cccc5nn3C)-c3ccnc(n3)N4)ncnc21 InChI=1S/C33H32FN11O2/c1-42-13-5-8-26-29-21(6-4-7-24(29)41-43(26)2)23-11-12-35-33(40-23)39-20-15-27(32(42)46)44(17-20)30-22-16-38-45(31(22)37-18-36-30)25-10-9-19(34)14-28(25)47-3/h4,6-7,9-12,14,16,18,20,27H,5,8,13,15,17H2,1-3H3,(H,35,39,40) IBKIFHUXNPFWCO-UHFFFAOYSA-N 796587 (8S,11S)-10-[1-(4-fluoro-2-methoxy-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-5,7,10,13,18,19,26-heptazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2,4,6(26),17::US20260070927, Example 6 Stimulator of interferon genes protein [139-379] Homo sapiens 5.00 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796587 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796587&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611378 528828050 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059965 CN1CCCc2c3c(cccc3nn2C)-c2cncc(n2)N[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C32H29F2N11O/c1-42-10-4-7-26-29-20(5-3-6-23(29)41-43(26)2)24-14-35-15-28(40-24)39-19-12-27(32(42)46)44(16-19)30-21-13-38-45(31(21)37-17-36-30)25-9-8-18(33)11-22(25)34/h3,5-6,8-9,11,13-15,17,19,27H,4,7,10,12,16H2,1-2H3,(H,39,40) YREUHKPEFQGMPI-UHFFFAOYSA-N 796588 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-4,7,10,13,18,19,26-heptazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2,4,6(26),17::US20260070927, Example 7 Stimulator of interferon genes protein [139-379] Homo sapiens 0.400 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796588 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796588&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611406 528828051 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059966 CN1CCCc2c3c(cccc3nn2C)-c2cncc(n2)N[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C32H29F2N11O/c1-42-10-4-7-26-29-20(5-3-6-23(29)41-43(26)2)24-14-35-15-28(40-24)39-19-12-27(32(42)46)44(16-19)30-21-13-38-45(31(21)37-17-36-30)25-9-8-18(33)11-22(25)34/h3,5-6,8-9,11,13-15,17,19,27H,4,7,10,12,16H2,1-2H3,(H,39,40) YREUHKPEFQGMPI-UHFFFAOYSA-N 796589 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-3,7,10,13,18,19,26-heptazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2,4,6(26),17::US20260070927, Example 8 Stimulator of interferon genes protein [139-379] Homo sapiens 0.200 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796589 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796589&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611406 528828052 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059969 CN1CCCc2c3c(cccc3nn2C)-c2cccc(n2)O[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C33H29F2N9O2/c1-41-13-5-9-27-30-21(6-3-8-25(30)40-42(27)2)24-7-4-10-29(39-24)46-20-15-28(33(41)45)43(17-20)31-22-16-38-44(32(22)37-18-36-31)26-12-11-19(34)14-23(26)35/h3-4,6-8,10-12,14,16,18,20,28H,5,9,13,15,17H2,1-2H3 UXDSVLASRRSKBO-UHFFFAOYSA-N 796590 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-7-oxa-10,13,18,19,26-pentazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 9 Stimulator of interferon genes protein [139-379] Homo sapiens 17.8 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796590&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611458 528828053 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059970 Cn1nc2cccc3c2c1CCCNC(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1ccnc-3c1 InChI=1S/C32H27F2N9O2/c1-41-27-6-3-10-36-32(44)28-14-20(45-19-9-11-35-25(13-19)21-4-2-5-24(40-41)29(21)27)16-42(28)30-22-15-39-43(31(22)38-17-37-30)26-8-7-18(33)12-23(26)34/h2,4-5,7-9,11-13,15,17,20,28H,3,6,10,14,16H2,1H3,(H,36,44) KRNDRQIMCGEKNF-UHFFFAOYSA-N 796591 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-7-oxa-3,10,13,18,19-pentazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 10 Stimulator of interferon genes protein [139-379] Homo sapiens 5.10 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796591&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444099 528828054 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059973 CN1CCCc2c3c(cccc3nn2C)-c2ccnc(n2)O[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C32H28F2N10O2/c1-41-12-4-7-26-28-20(5-3-6-24(28)40-42(26)2)23-10-11-35-32(39-23)46-19-14-27(31(41)45)43(16-19)29-21-15-38-44(30(21)37-17-36-29)25-9-8-18(33)13-22(25)34/h3,5-6,8-11,13,15,17,19,27H,4,7,12,14,16H2,1-2H3 FPMLFSKYYLWUBX-UHFFFAOYSA-N 796592 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-7-oxa-5,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 11 Stimulator of interferon genes protein [139-379] Homo sapiens 21.4 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796592 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796592&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611479 528828055 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059974 COc1cc(F)ccc1-n1ncc2c(N3C[C@@H]4C[C@H]3C(=O)N(C)CCCc3c5c(cc(F)cc5nn3C)-c3ccnc(n3)O4)ncnc21 InChI=1S/C33H30F2N10O3/c1-42-10-4-5-26-29-21(11-19(35)12-24(29)41-43(26)2)23-8-9-36-33(40-23)48-20-14-27(32(42)46)44(16-20)30-22-15-39-45(31(22)38-17-37-30)25-7-6-18(34)13-28(25)47-3/h6-9,11-13,15,17,20,27H,4-5,10,14,16H2,1-3H3 QOASMYFIEBXVKW-UHFFFAOYSA-N 796593 (8S,11S)-22-fluoro-10-[1-(4-fluoro-2-methoxy-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-7-oxa-5,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 12 Stimulator of interferon genes protein [139-379] Homo sapiens 18.0 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796593 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796593&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444125 528828056 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059977 COc1cc2nc(c1)-c1cccc3nn(C)c(c13)CCCN(C)C(=O)[C@@H]1C[C@@H](CN1c1ncnc3c1cnn3-c1ccc(F)cc1F)N2 InChI=1S/C34H32F2N10O2/c1-43-11-5-8-28-31-22(6-4-7-25(31)42-44(28)2)26-14-21(48-3)15-30(41-26)40-20-13-29(34(43)47)45(17-20)32-23-16-39-46(33(23)38-18-37-32)27-10-9-19(35)12-24(27)36/h4,6-7,9-10,12,14-16,18,20,29H,5,8,11,13,17H2,1-3H3,(H,40,41) VZJNVVKKPDARRR-UHFFFAOYSA-N 796594 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-4-methoxy-13,18-dimethyl-7,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2,4,6(26),17::US20260070927, Example 13 Stimulator of interferon genes protein [139-379] Homo sapiens 4.70 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796594 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796594&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611481 528828057 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059980 COc1cc2nc(c1)-c1cccc3nn(C)c(c13)CCCN(C)C(=O)[C@@H]1C[C@@H](CN1c1ncnc3c1cnn3-c1ccc(F)cc1OC)N2 InChI=1S/C35H35FN10O3/c1-43-12-6-9-28-32-23(7-5-8-25(32)42-44(28)2)26-15-22(48-3)16-31(41-26)40-21-14-29(35(43)47)45(18-21)33-24-17-39-46(34(24)38-19-37-33)27-11-10-20(36)13-30(27)49-4/h5,7-8,10-11,13,15-17,19,21,29H,6,9,12,14,18H2,1-4H3,(H,40,41) WTIPKFKVQQWXIX-UHFFFAOYSA-N 796595 (8S,11S)-10-[1-(4-fluoro-2-methoxy-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-4-methoxy-13,18-dimethyl-7,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2,4,6(26),17::US20260070927, Example 14 Stimulator of interferon genes protein [139-379] Homo sapiens 4.80 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796595 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796595&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611437 528828058 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059983 Cn1nc2cccc3c2c1CCCN(CC1CC1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C37H34F2N8O2/c1-44-32-9-4-14-45(19-22-10-11-22)37(48)33-17-26(49-25-6-2-5-23(15-25)27-7-3-8-30(43-44)34(27)32)20-46(33)35-28-18-42-47(36(28)41-21-40-35)31-13-12-24(38)16-29(31)39/h2-3,5-8,12-13,15-16,18,21-22,26,33H,4,9-11,14,17,19-20H2,1H3 HLMPRWOCEBBQSU-UHFFFAOYSA-N 796596 (8S,11S)-13-(cyclopropylmethyl)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 15 Stimulator of interferon genes protein [139-379] Homo sapiens 1.60 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796596 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796596&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444170 528828059 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059984 Cn1cnc(CN2CCCc3c4c(cccc4nn3C)-c3cccc(c3)O[C@H]3C[C@@H](C2=O)N(c2ncnc4c2cnn4-c2ccc(F)cc2F)C3)n1 InChI=1S/C37H33F2N11O2/c1-46-21-42-33(45-46)19-48-13-5-10-31-34-26(8-4-9-29(34)44-47(31)2)22-6-3-7-24(14-22)52-25-16-32(37(48)51)49(18-25)35-27-17-43-50(36(27)41-20-40-35)30-12-11-23(38)15-28(30)39/h3-4,6-9,11-12,14-15,17,20-21,25,32H,5,10,13,16,18-19H2,1-2H3 GBGZDTKJZPXGHA-UHFFFAOYSA-N 796597 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-[(1-methyl-1,2,4-triazol-3-yl)methyl]-7-oxa-10,13,18,19 tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 16 Stimulator of interferon genes protein [139-379] Homo sapiens 3.10 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796597&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444217 528828060 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059987 Cn1nc2cccc3c2c1CCCN(Cc1cscn1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C37H31F2N9O2S/c1-45-32-9-4-12-46(17-24-19-51-21-42-24)37(49)33-15-26(50-25-6-2-5-22(13-25)27-7-3-8-30(44-45)34(27)32)18-47(33)35-28-16-43-48(36(28)41-20-40-35)31-11-10-23(38)14-29(31)39/h2-3,5-8,10-11,13-14,16,19-21,26,33H,4,9,12,15,17-18H2,1H3 BTHZKAAALZQUDF-UHFFFAOYSA-N 796598 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-(thiazol-4-ylmethyl)-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 17 Stimulator of interferon genes protein [139-379] Homo sapiens 2.20 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796598 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796598&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444255 528828061 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059990 Cn1nc2cccc3c2c1CCCN(CC1CC1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cc-3ncn1 InChI=1S/C35H32F2N10O2/c1-44-29-6-3-11-45(16-20-7-8-20)35(48)30-13-22(49-31-14-27(38-18-39-31)23-4-2-5-26(43-44)32(23)29)17-46(30)33-24-15-42-47(34(24)41-19-40-33)28-10-9-21(36)12-25(28)37/h2,4-5,9-10,12,14-15,18-20,22,30H,3,6-8,11,13,16-17H2,1H3 BGULFBQXTSNHPX-UHFFFAOYSA-N 796599 (8S,11S)-13-(cyclopropylmethyl)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-7-oxa-3,5,10,13,18,19-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 18 Stimulator of interferon genes protein [139-379] Homo sapiens 12.5 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796599 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796599&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611372 528828062 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059993 Cn1nc2cccc3c2c1CCCN(CC1CC1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1nccc-3n1 InChI=1S/C35H32F2N10O2/c1-44-29-6-3-13-45(17-20-7-8-20)34(48)30-15-22(49-35-38-12-11-26(42-35)23-4-2-5-27(43-44)31(23)29)18-46(30)32-24-16-41-47(33(24)40-19-39-32)28-10-9-21(36)14-25(28)37/h2,4-5,9-12,14,16,19-20,22,30H,3,6-8,13,15,17-18H2,1H3 ZQSQGAPCKVRUSI-UHFFFAOYSA-N 796600 (8S,11S)-13-(cyclopropylmethyl)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-7-oxa-5,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 19 Stimulator of interferon genes protein [139-379] Homo sapiens 13.1 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796600 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796600&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611395 528828063 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059994 C=CCN1CCCc2c3c(cccc3nn2C)-c2cccc(c2)O[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C36H32F2N8O2/c1-3-14-44-15-6-11-31-33-26(9-5-10-29(33)42-43(31)2)22-7-4-8-24(16-22)48-25-18-32(36(44)47)45(20-25)34-27-19-41-46(35(27)40-21-39-34)30-13-12-23(37)17-28(30)38/h3-5,7-10,12-13,16-17,19,21,25,32H,1,6,11,14-15,18,20H2,2H3 MYRKLJPKYUGSFH-UHFFFAOYSA-N 796601 (8S,11S)-13-allyl-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 20 Stimulator of interferon genes protein [139-379] Homo sapiens 1.90 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796601 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796601&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444276 528828064 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059995 COCCN1CCCc2c3c(cccc3nn2C)-c2cccc(c2)O[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C36H34F2N8O3/c1-43-31-10-5-13-44(14-15-48-2)36(47)32-18-25(49-24-7-3-6-22(16-24)26-8-4-9-29(42-43)33(26)31)20-45(32)34-27-19-41-46(35(27)40-21-39-34)30-12-11-23(37)17-28(30)38/h3-4,6-9,11-12,16-17,19,21,25,32H,5,10,13-15,18,20H2,1-2H3 HPLYBWBDTXJNJT-UHFFFAOYSA-N 796602 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13-(2-methoxyethyl)-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 21 Stimulator of interferon genes protein [139-379] Homo sapiens 2.00 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796602 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796602&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444298 528828065 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059996 Cn1nc2cccc3c2c1CCCN(CCO)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C35H32F2N8O3/c1-42-30-9-4-12-43(13-14-46)35(47)31-17-24(48-23-6-2-5-21(15-23)25-7-3-8-28(41-42)32(25)30)19-44(31)33-26-18-40-45(34(26)39-20-38-33)29-11-10-22(36)16-27(29)37/h2-3,5-8,10-11,15-16,18,20,24,31,46H,4,9,12-14,17,19H2,1H3 VSLUGOIBGDAZCA-UHFFFAOYSA-N 796603 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13-(2-hydroxyethyl)-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 22 Stimulator of interferon genes protein [139-379] Homo sapiens 0.200 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796603&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444329 528828066 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059997 Cn1nc2cccc3c2c1CCCN(CCN1CCOCC1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C39H39F2N9O3/c1-46-34-9-4-12-48(14-13-47-15-17-52-18-16-47)39(51)35-21-28(53-27-6-2-5-25(19-27)29-7-3-8-32(45-46)36(29)34)23-49(35)37-30-22-44-50(38(30)43-24-42-37)33-11-10-26(40)20-31(33)41/h2-3,5-8,10-11,19-20,22,24,28,35H,4,9,12-18,21,23H2,1H3 BIEKBJDSKWMNHV-UHFFFAOYSA-N 796604 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-(2-morpholinoethyl)-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 23 Stimulator of interferon genes protein [139-379] Homo sapiens 1.60 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796604&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444361 528828067 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059998 CN(C)CCN1CCCc2c3c(cccc3nn2C)-c2cccc(c2)O[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C37H37F2N9O2/c1-44(2)15-16-46-14-6-11-32-34-27(9-5-10-30(34)43-45(32)3)23-7-4-8-25(17-23)50-26-19-33(37(46)49)47(21-26)35-28-20-42-48(36(28)41-22-40-35)31-13-12-24(38)18-29(31)39/h4-5,7-10,12-13,17-18,20,22,26,33H,6,11,14-16,19,21H2,1-3H3 WIUASSODGNZXHW-UHFFFAOYSA-N 796605 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13-[2-(dimethylamino)ethyl]-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 24 Stimulator of interferon genes protein [139-379] Homo sapiens 8.20 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796605&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444382 528828068 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1059999 Cn1nc2cc(F)cc3c2c1CCCN(CCN1CCOCC1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C39H38F3N9O3/c1-47-34-6-3-9-49(11-10-48-12-14-53-15-13-48)39(52)35-20-28(54-27-5-2-4-24(16-27)29-17-26(41)19-32(46-47)36(29)34)22-50(35)37-30-21-45-51(38(30)44-23-43-37)33-8-7-25(40)18-31(33)42/h2,4-5,7-8,16-19,21,23,28,35H,3,6,9-15,20,22H2,1H3 RCCMLOBXLSUTLE-UHFFFAOYSA-N 796606 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-22-fluoro-18-methyl-13-(2-morpholinoethyl)-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 25 Stimulator of interferon genes protein [139-379] Homo sapiens 18.4 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796606&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611442 528828069 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060002 Cn1nc2cccc3c2c1CCCN(CCCO)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C36H34F2N8O3/c1-43-31-10-4-13-44(14-5-15-47)36(48)32-18-25(49-24-7-2-6-22(16-24)26-8-3-9-29(42-43)33(26)31)20-45(32)34-27-19-41-46(35(27)40-21-39-34)30-12-11-23(37)17-28(30)38/h2-3,6-9,11-12,16-17,19,21,25,32,47H,4-5,10,13-15,18,20H2,1H3 BULSHYHHDUGYNT-UHFFFAOYSA-N 796607 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13-(3-hydroxypropyl)-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 26 Stimulator of interferon genes protein [139-379] Homo sapiens 2.20 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796607&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444426 528828070 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060003 COCCCN1CCCc2c3c(cccc3nn2C)-c2cccc(c2)O[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C37H36F2N8O3/c1-44-32-11-5-14-45(15-6-16-49-2)37(48)33-19-26(50-25-8-3-7-23(17-25)27-9-4-10-30(43-44)34(27)32)21-46(33)35-28-20-42-47(36(28)41-22-40-35)31-13-12-24(38)18-29(31)39/h3-4,7-10,12-13,17-18,20,22,26,33H,5-6,11,14-16,19,21H2,1-2H3 XWNRZIWODOQDAD-UHFFFAOYSA-N 796608 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13-(3-methoxypropyl)-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 27 Stimulator of interferon genes protein [139-379] Homo sapiens 14.2 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796608 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796608&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444437 528828071 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060006 Cn1nc2cccc3c2c1CCCN(CCOCc1ccncc1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C41H37F2N9O3/c1-49-36-9-4-16-50(17-18-54-24-26-12-14-44-15-13-26)41(53)37-21-30(55-29-6-2-5-27(19-29)31-7-3-8-34(48-49)38(31)36)23-51(37)39-32-22-47-52(40(32)46-25-45-39)35-11-10-28(42)20-33(35)43/h2-3,5-8,10-15,19-20,22,25,30,37H,4,9,16-18,21,23-24H2,1H3 NETUGEMYQPPOAF-UHFFFAOYSA-N 796609 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-[2-(4-pyridylmethoxy)ethyl]-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 28 Stimulator of interferon genes protein [139-379] Homo sapiens 0.200 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796609 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796609&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444465 528828072 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060009 Cn1nc2cccc3c2c1CCCN(CCCc1ccccc1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C42H38F2N8O2/c1-49-37-16-8-20-50(19-7-11-27-9-3-2-4-10-27)42(53)38-23-31(54-30-13-5-12-28(21-30)32-14-6-15-35(48-49)39(32)37)25-51(38)40-33-24-47-52(41(33)46-26-45-40)36-18-17-29(43)22-34(36)44/h2-6,9-10,12-15,17-18,21-22,24,26,31,38H,7-8,11,16,19-20,23,25H2,1H3 XVIUUWNKDINGEU-UHFFFAOYSA-N 796610 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-(3-phenylpropyl)-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 29 Stimulator of interferon genes protein [139-379] Homo sapiens 1.20 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796610 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796610&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444492 528828073 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060010 Cn1nc2cccc3c2c1CCCN(CCCN1CCOCC1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C40H41F2N9O3/c1-47-35-10-4-14-49(15-5-13-48-16-18-53-19-17-48)40(52)36-22-29(54-28-7-2-6-26(20-28)30-8-3-9-33(46-47)37(30)35)24-50(36)38-31-23-45-51(39(31)44-25-43-38)34-12-11-27(41)21-32(34)42/h2-3,6-9,11-12,20-21,23,25,29,36H,4-5,10,13-19,22,24H2,1H3 WGECXKDPYILAIU-UHFFFAOYSA-N 796611 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-(3-morpholinopropyl)-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 30 Stimulator of interferon genes protein [139-379] Homo sapiens 2.00 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796611 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796611&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444563 528828074 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060013 Cn1nc2cccc3c2c1CCCN(CCCN1CC2(COC2)C1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C41H41F2N9O3/c1-48-35-10-4-14-50(15-5-13-49-21-41(22-49)23-54-24-41)40(53)36-18-29(55-28-7-2-6-26(16-28)30-8-3-9-33(47-48)37(30)35)20-51(36)38-31-19-46-52(39(31)45-25-44-38)34-12-11-27(42)17-32(34)43/h2-3,6-9,11-12,16-17,19,25,29,36H,4-5,10,13-15,18,20-24H2,1H3 XSCZOHZMTWIIQH-UHFFFAOYSA-N 796612 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-[3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)propyl]-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 31 Stimulator of interferon genes protein [139-379] Homo sapiens 7.20 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796612 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796612&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611369 528828075 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060014 CN1CCN(CCCN2CCCc3c4c(cccc4nn3C)-c3cccc(c3)O[C@H]3C[C@@H](C2=O)N(c2ncnc4c2cnn4-c2ccc(F)cc2F)C3)CC1 InChI=1S/C41H44F2N10O2/c1-48-17-19-50(20-18-48)14-6-16-51-15-5-11-36-38-31(9-4-10-34(38)47-49(36)2)27-7-3-8-29(21-27)55-30-23-37(41(51)54)52(25-30)39-32-24-46-53(40(32)45-26-44-39)35-13-12-28(42)22-33(35)43/h3-4,7-10,12-13,21-22,24,26,30,37H,5-6,11,14-20,23,25H2,1-2H3 BFVKVIARHUXOHQ-UHFFFAOYSA-N 796613 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-[3-(4-methylpiperazin-1-yl)propyl]-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 32 Stimulator of interferon genes protein [139-379] Homo sapiens 3.20 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796613 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796613&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444650 528828076 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060017 CC(=O)N1CCN(CCCN2CCCc3c4c(cccc4nn3C)-c3cccc(c3)O[C@H]3C[C@@H](C2=O)N(c2ncnc4c2cnn4-c2ccc(F)cc2F)C3)CC1 InChI=1S/C42H44F2N10O3/c1-27(55)51-19-17-50(18-20-51)14-6-16-52-15-5-11-37-39-32(9-4-10-35(39)48-49(37)2)28-7-3-8-30(21-28)57-31-23-38(42(52)56)53(25-31)40-33-24-47-54(41(33)46-26-45-40)36-13-12-29(43)22-34(36)44/h3-4,7-10,12-13,21-22,24,26,31,38H,5-6,11,14-20,23,25H2,1-2H3 BJJVFGMKWOJTDM-UHFFFAOYSA-N 796614 (8S,11S)-13-[3-(4-acetylpiperazin-1-yl)propyl]-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 33 Stimulator of interferon genes protein [139-379] Homo sapiens 1.70 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796614&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444690 528828077 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060020 CN1CC2CC1CN2CCCN1CCCc2c3c(cccc3nn2C)-c2cccc(c2)O[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C42H44F2N10O2/c1-49-22-29-19-28(49)23-52(29)16-6-15-51-14-5-11-37-39-32(9-4-10-35(39)48-50(37)2)26-7-3-8-30(17-26)56-31-20-38(42(51)55)53(24-31)40-33-21-47-54(41(33)46-25-45-40)36-13-12-27(43)18-34(36)44/h3-4,7-10,12-13,17-18,21,25,28-29,31,38H,5-6,11,14-16,19-20,22-24H2,1-2H3 WYHAJDMCFFIGED-UHFFFAOYSA-N 796615 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-[3-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)propyl]-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 34 Stimulator of interferon genes protein [139-379] Homo sapiens 7.00 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796615 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796615&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444706 528828078 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060021 Cn1nc2cccc3c2c1CCCN(CCCN1CCN(S(C)(=O)=O)CC1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C41H44F2N10O4S/c1-48-36-11-5-15-50(16-6-14-49-17-19-51(20-18-49)58(2,55)56)41(54)37-23-30(57-29-8-3-7-27(21-29)31-9-4-10-34(47-48)38(31)36)25-52(37)39-32-24-46-53(40(32)45-26-44-39)35-13-12-28(42)22-33(35)43/h3-4,7-10,12-13,21-22,24,26,30,37H,5-6,11,14-20,23,25H2,1-2H3 WCSAVZVVWNIERA-UHFFFAOYSA-N 796616 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-[3-(4-methylsulfonylpiperazin-1-yl)propyl]-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 35 Stimulator of interferon genes protein [139-379] Homo sapiens 0.200 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796616 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796616&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444717 528828079 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060022 Cn1nc2cccc3c2c1CCCN(CCCn1cnnn1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C37H34F2N12O2/c1-47-32-10-4-13-48(14-5-15-49-22-42-45-46-49)37(52)33-18-26(53-25-7-2-6-23(16-25)27-8-3-9-30(44-47)34(27)32)20-50(33)35-28-19-43-51(36(28)41-21-40-35)31-12-11-24(38)17-29(31)39/h2-3,6-9,11-12,16-17,19,21-22,26,33H,4-5,10,13-15,18,20H2,1H3 RVNYUPGVTCVWMP-UHFFFAOYSA-N 796617 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-[3-(tetrazol-1-yl)propyl]-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 36 Stimulator of interferon genes protein [139-379] Homo sapiens 1.30 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796617 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796617&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611426 528828080 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060025 Cn1nc2cccc3c2c1CCCN(CCCn1cncn1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C38H35F2N11O2/c1-47-33-10-4-13-48(14-5-15-49-23-41-21-45-49)38(52)34-18-27(53-26-7-2-6-24(16-26)28-8-3-9-31(46-47)35(28)33)20-50(34)36-29-19-44-51(37(29)43-22-42-36)32-12-11-25(39)17-30(32)40/h2-3,6-9,11-12,16-17,19,21-23,27,34H,4-5,10,13-15,18,20H2,1H3 VHSPPSICOZETIP-UHFFFAOYSA-N 796618 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-[3-(1,2,4-triazol-1-yl)propyl]-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 37 Stimulator of interferon genes protein [139-379] Homo sapiens 1.50 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796618 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796618&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444747 528828081 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060028 Cn1nc2cccc3c2c1CCCN(CCCn1ccnc1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C39H36F2N10O2/c1-47-34-10-4-15-49(16-5-14-48-17-13-42-24-48)39(52)35-20-28(53-27-7-2-6-25(18-27)29-8-3-9-32(46-47)36(29)34)22-50(35)37-30-21-45-51(38(30)44-23-43-37)33-12-11-26(40)19-31(33)41/h2-3,6-9,11-13,17-19,21,23-24,28,35H,4-5,10,14-16,20,22H2,1H3 HOLCOEWBJQWHMY-UHFFFAOYSA-N 796619 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13-(3-imidazol-1-ylpropyl)-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 38 Stimulator of interferon genes protein [139-379] Homo sapiens 0.900 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796619 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796619&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444758 528828082 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060029 COCCOCCCN1CCCc2c3c(cccc3nn2C)-c2cccc(c2)O[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C39H40F2N8O4/c1-46-34-11-5-14-47(15-6-16-52-18-17-51-2)39(50)35-21-28(53-27-8-3-7-25(19-27)29-9-4-10-32(45-46)36(29)34)23-48(35)37-30-22-44-49(38(30)43-24-42-37)33-13-12-26(40)20-31(33)41/h3-4,7-10,12-13,19-20,22,24,28,35H,5-6,11,14-18,21,23H2,1-2H3 QQPZAOHWRZLXAG-UHFFFAOYSA-N 796620 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13-[3-(2-methoxyethoxy)propyl]-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 39 Stimulator of interferon genes protein [139-379] Homo sapiens 5.50 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796620 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796620&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444769 528828083 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060032 Cn1nc2cccc3c2c1CCCN(CCC(C)(C)O)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3c1 InChI=1S/C38H38F2N8O3/c1-38(2,50)14-16-46-15-6-11-32-34-27(9-5-10-30(34)44-45(32)3)23-7-4-8-25(17-23)51-26-19-33(37(46)49)47(21-26)35-28-20-43-48(36(28)42-22-41-35)31-13-12-24(39)18-29(31)40/h4-5,7-10,12-13,17-18,20,22,26,33,50H,6,11,14-16,19,21H2,1-3H3 IZWGGSFMNKXXTH-UHFFFAOYSA-N 796621 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13-(3-hydroxy-3-methyl-butyl)-18-methyl-7-oxa-10,13,18,19-tetrazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 40 Stimulator of interferon genes protein [139-379] Homo sapiens 8.60 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796621 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796621&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444790 528828084 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060033 Cn1nc2cccc3c2c1CCCN(CCCc1ccccc1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1cccc-3n1 InChI=1S/C41H37F2N9O2/c1-49-35-15-8-20-50(19-7-11-26-9-3-2-4-10-26)41(53)36-22-28(54-37-16-6-13-32(47-37)29-12-5-14-33(48-49)38(29)35)24-51(36)39-30-23-46-52(40(30)45-25-44-39)34-18-17-27(42)21-31(34)43/h2-6,9-10,12-14,16-18,21,23,25,28,36H,7-8,11,15,19-20,22,24H2,1H3 MEKIUPNKSQTHNQ-UHFFFAOYSA-N 796622 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-(3-phenylpropyl)-7-oxa-10,13,18,19,26-pentazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 41 Stimulator of interferon genes protein [139-379] Homo sapiens 2.10 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796622 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796622&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444808 528828085 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060036 Cn1nc2cccc3c2c1CCCN(CCCO)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Nc1cccc-3n1 InChI=1S/C35H34F2N10O2/c1-44-29-9-4-13-45(14-5-15-48)35(49)30-17-22(41-31-10-3-7-26(42-31)23-6-2-8-27(43-44)32(23)29)19-46(30)33-24-18-40-47(34(24)39-20-38-33)28-12-11-21(36)16-25(28)37/h2-3,6-8,10-12,16,18,20,22,30,48H,4-5,9,13-15,17,19H2,1H3,(H,41,42) WAXYIEYBJUZDNV-UHFFFAOYSA-N 796623 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13-(3-hydroxypropyl)-18-methyl-7,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 42 Stimulator of interferon genes protein [139-379] Homo sapiens 5.30 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796623 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796623&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611438 528828086 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060037 COc1cc(F)ccc1-n1ncc2c(N3C[C@@H]4C[C@H]3C(=O)N(CCCN3CCOCC3)CCCc3c5c(cccc5nn3C)-c3cccc(n3)N4)ncnc21 InChI=1S/C40H44FN11O3/c1-48-33-10-5-15-50(16-6-14-49-17-19-55-20-18-49)40(53)34-22-27(45-36-11-4-8-30(46-36)28-7-3-9-31(47-48)37(28)33)24-51(34)38-29-23-44-52(39(29)43-25-42-38)32-13-12-26(41)21-35(32)54-2/h3-4,7-9,11-13,21,23,25,27,34H,5-6,10,14-20,22,24H2,1-2H3,(H,45,46) LXGIHLOPVPADJB-UHFFFAOYSA-N 796624 (8S,11S)-10-[1-(4-fluoro-2-methoxy-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-(3-morpholinopropyl)-7,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 43 Stimulator of interferon genes protein [139-379] Homo sapiens 3.50 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796624 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796624&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444828 528828087 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060038 Cn1nc2c(F)ccc3c2c1CCCN(CCCN1CCOCC1)C(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Nc1cccc-3n1 InChI=1S/C39H40F3N11O2/c1-49-32-6-3-13-51(14-4-12-50-15-17-55-18-16-50)39(54)33-20-25(46-34-7-2-5-30(47-34)26-9-10-28(41)36(48-49)35(26)32)22-52(33)37-27-21-45-53(38(27)44-23-43-37)31-11-8-24(40)19-29(31)42/h2,5,7-11,19,21,23,25,33H,3-4,6,12-18,20,22H2,1H3,(H,46,47) ZLIBYEDTOBWRFZ-UHFFFAOYSA-N 796625 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-21-fluoro-18-methyl-13-(3-morpholinopropyl)-7,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 44 Stimulator of interferon genes protein [139-379] Homo sapiens 6.30 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796625 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796625&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611398 528828088 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060041 COc1cc(F)ccc1-n1ncc2c(N3C[C@@H]4C[C@H]3C(=O)N(CCCN3CCOCC3)CCCc3c5c(ccc(F)c5nn3C)-c3cccc(n3)N4)ncnc21 InChI=1S/C40H43F2N11O3/c1-49-32-7-4-14-51(15-5-13-50-16-18-56-19-17-50)40(54)33-21-26(46-35-8-3-6-30(47-35)27-10-11-29(42)37(48-49)36(27)32)23-52(33)38-28-22-45-53(39(28)44-24-43-38)31-12-9-25(41)20-34(31)55-2/h3,6,8-12,20,22,24,26,33H,4-5,7,13-19,21,23H2,1-2H3,(H,46,47) DHAMFQROHXISOD-UHFFFAOYSA-N 796626 (8S,11S)-21-fluoro-10-[1-(4-fluoro-2-methoxy-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-(3-morpholinopropyl)-7,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 45 Stimulator of interferon genes protein [139-379] Homo sapiens 3.90 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796626 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796626&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611441 528828089 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060044 COc1cc(F)ccc1-n1ncc2c(N3C[C@@H]4C[C@H]3C(=O)N(CCCN3CCOCC3)CCCc3c5c(cccc5nn3C)-c3cc(C)cc(n3)N4)ncnc21 InChI=1S/C41H46FN11O3/c1-26-19-32-29-7-4-8-31-38(29)34(49(2)48-31)9-5-13-51(14-6-12-50-15-17-56-18-16-50)41(54)35-22-28(46-37(20-26)47-32)24-52(35)39-30-23-45-53(40(30)44-25-43-39)33-11-10-27(42)21-36(33)55-3/h4,7-8,10-11,19-21,23,25,28,35H,5-6,9,12-18,22,24H2,1-3H3,(H,46,47) YTBBDSNFGPRBNR-UHFFFAOYSA-N 796627 (8S,11S)-10-[1-(4-fluoro-2-methoxy-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-4,18-dimethyl-13-(3-morpholinopropyl)-7,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 46 Stimulator of interferon genes protein [139-379] Homo sapiens 7.60 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796627 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796627&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170611416 528828090 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060047 COc1cc(F)ccc1-n1ncc2c(N3C[C@@H]4C[C@H]3C(=O)N(CCCN3CCOCC3)CCCc3c5c(cccc5nn3C)-c3cccc(n3)N4)ncnc21 InChI=1S/C40H44FN11O3/c1-48-33-10-5-15-50(16-6-14-49-17-19-55-20-18-49)40(53)34-22-27(45-36-11-4-8-30(46-36)28-7-3-9-31(47-48)37(28)33)24-51(34)38-29-23-44-52(39(29)43-25-42-38)32-13-12-26(41)21-35(32)54-2/h3-4,7-9,11-13,21,23,25,27,34H,5-6,10,14-20,22,24H2,1-2H3,(H,45,46) LXGIHLOPVPADJB-UHFFFAOYSA-N 796628 (8S,11S)-10-[1-(4-fluoro-2-methoxy-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-(3-morpholinopropyl)-5,7,10,13,18,19,26-heptazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 47 Stimulator of interferon genes protein [139-379] Homo sapiens 7.20 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796628 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1291&target=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796628&enzyme=Stimulator+of+interferon+genes+protein+%5B139-379%5D&column=ki&startPg=0&Increment=50&submit=Search 170444828 528828091 1 LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS 4F9G,4F9E,4EF5,4EF4,9SWR,9SWM,8YWB,8GT6,7X9Q,7X9P,6YWA,7T9V,7T9U,9JW6,8Z37,9KYA Stimulator of interferon genes protein STING_HUMAN Q86WV6 A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9 1060050 COc1cc(F)ccc1-n1ncc2c(N3C[C@@H]4C[C@H]3C(=O)N(C)CCCc3c5c(cccc5nn3C)-c3ccnc(n3)N4)ncnc21 InChI=1S/C33H32FN11O2/c1-42-13-5-8-26-29-21(6-4-7-24(29)41-43(26)2)23-11-12-35-33(40-23)39-20-15-27(32(42)46)44(17-20)30-22-16-38-45(31(22)37-18-36-30)25-10-9-19(34)14-28(25)47-3/h4,6-7,9-12,14,16,18,20,27H,5,8,13,15,17H2,1-3H3,(H,35,39,40) IBKIFHUXNPFWCO-UHFFFAOYSA-N 796587 (8S,11S)-10-[1-(4-fluoro-2-methoxy-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-5,7,10,13,18,19,26-heptazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2,4,6(26),17::US20260070927, Example 6 Potassium voltage-gated channel subfamily H member 2 Homo sapiens >20000 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796587 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2132&target=Potassium+voltage-gated+channel+subfamily+H+member+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796587&enzyme=Potassium+voltage-gated+channel+subfamily+H+member+2&column=ki&startPg=0&Increment=50&submit=Search 170611378 528828050 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 8IOB,8IO5,8IO4,5VA2,8ZYQ,8ZYP,8ZYO,8ZYN,7CN1,7CN0,5VA1,9CHS,9CHR,9CHQ,9CHP,5VA3,2L4R,4HQA,2L0W,6SYG,2N7G Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2_HUMAN Q12809 A5H1P7 C4PFH9 D3DX04 O75418 O75680 Q708S9 Q9BT72 Q9BUT7 Q9H3P0 N/A A0A090N8Q0 1060051 CN1CCCc2c3c(cccc3nn2C)-c2cccc(n2)O[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C33H29F2N9O2/c1-41-13-5-9-27-30-21(6-3-8-25(30)40-42(27)2)24-7-4-10-29(39-24)46-20-15-28(33(41)45)43(17-20)31-22-16-38-44(32(22)37-18-36-31)26-12-11-19(34)14-23(26)35/h3-4,6-8,10-12,14,16,18,20,28H,5,9,13,15,17H2,1-2H3 UXDSVLASRRSKBO-UHFFFAOYSA-N 796590 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-7-oxa-10,13,18,19,26-pentazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 9 Potassium voltage-gated channel subfamily H member 2 Homo sapiens >20000 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2132&target=Potassium+voltage-gated+channel+subfamily+H+member+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796590&enzyme=Potassium+voltage-gated+channel+subfamily+H+member+2&column=ki&startPg=0&Increment=50&submit=Search 170611458 528828053 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 8IOB,8IO5,8IO4,5VA2,8ZYQ,8ZYP,8ZYO,8ZYN,7CN1,7CN0,5VA1,9CHS,9CHR,9CHQ,9CHP,5VA3,2L4R,4HQA,2L0W,6SYG,2N7G Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2_HUMAN Q12809 A5H1P7 C4PFH9 D3DX04 O75418 O75680 Q708S9 Q9BT72 Q9BUT7 Q9H3P0 N/A A0A090N8Q0 1060052 Cn1nc2cccc3c2c1CCCNC(=O)[C@@H]1C[C@@H](CN1c1ncnc2c1cnn2-c1ccc(F)cc1F)Oc1ccnc-3c1 InChI=1S/C32H27F2N9O2/c1-41-27-6-3-10-36-32(44)28-14-20(45-19-9-11-35-25(13-19)21-4-2-5-24(40-41)29(21)27)16-42(28)30-22-15-39-43(31(22)38-17-37-30)26-8-7-18(33)12-23(26)34/h2,4-5,7-9,11-13,15,17,20,28H,3,6,10,14,16H2,1H3,(H,36,44) KRNDRQIMCGEKNF-UHFFFAOYSA-N 796591 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-7-oxa-3,10,13,18,19-pentazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 10 Potassium voltage-gated channel subfamily H member 2 Homo sapiens >10000 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2132&target=Potassium+voltage-gated+channel+subfamily+H+member+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796591&enzyme=Potassium+voltage-gated+channel+subfamily+H+member+2&column=ki&startPg=0&Increment=50&submit=Search 170444099 528828054 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 8IOB,8IO5,8IO4,5VA2,8ZYQ,8ZYP,8ZYO,8ZYN,7CN1,7CN0,5VA1,9CHS,9CHR,9CHQ,9CHP,5VA3,2L4R,4HQA,2L0W,6SYG,2N7G Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2_HUMAN Q12809 A5H1P7 C4PFH9 D3DX04 O75418 O75680 Q708S9 Q9BT72 Q9BUT7 Q9H3P0 N/A A0A090N8Q0 1060055 CN1CCCc2c3c(cccc3nn2C)-c2ccnc(n2)O[C@H]2C[C@@H](C1=O)N(c1ncnc3c1cnn3-c1ccc(F)cc1F)C2 InChI=1S/C32H28F2N10O2/c1-41-12-4-7-26-28-20(5-3-6-24(28)40-42(26)2)23-10-11-35-32(39-23)46-19-14-27(31(41)45)43(16-19)29-21-15-38-44(30(21)37-17-36-29)25-9-8-18(33)13-22(25)34/h3,5-6,8-11,13,15,17,19,27H,4,7,12,14,16H2,1-2H3 FPMLFSKYYLWUBX-UHFFFAOYSA-N 796592 (8S,11S)-10-[1-(2,4-difluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-13,18-dimethyl-7-oxa-5,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 11 Potassium voltage-gated channel subfamily H member 2 Homo sapiens >20000 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796592 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2132&target=Potassium+voltage-gated+channel+subfamily+H+member+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796592&enzyme=Potassium+voltage-gated+channel+subfamily+H+member+2&column=ki&startPg=0&Increment=50&submit=Search 170611479 528828055 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 8IOB,8IO5,8IO4,5VA2,8ZYQ,8ZYP,8ZYO,8ZYN,7CN1,7CN0,5VA1,9CHS,9CHR,9CHQ,9CHP,5VA3,2L4R,4HQA,2L0W,6SYG,2N7G Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2_HUMAN Q12809 A5H1P7 C4PFH9 D3DX04 O75418 O75680 Q708S9 Q9BT72 Q9BUT7 Q9H3P0 N/A A0A090N8Q0 1060058 COc1cc(F)ccc1-n1ncc2c(N3C[C@@H]4C[C@H]3C(=O)N(CCCN3CCOCC3)CCCc3c5c(cccc5nn3C)-c3cccc(n3)N4)ncnc21 InChI=1S/C40H44FN11O3/c1-48-33-10-5-15-50(16-6-14-49-17-19-55-20-18-49)40(53)34-22-27(45-36-11-4-8-30(46-36)28-7-3-9-31(47-48)37(28)33)24-51(34)38-29-23-44-52(39(29)43-25-42-38)32-13-12-26(41)21-35(32)54-2/h3-4,7-9,11-13,21,23,25,27,34H,5-6,10,14-20,22,24H2,1-2H3,(H,45,46) LXGIHLOPVPADJB-UHFFFAOYSA-N 796624 (8S,11S)-10-[1-(4-fluoro-2-methoxy-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-18-methyl-13-(3-morpholinopropyl)-7,10,13,18,19,26-hexazapentacyclo[15.6.1.12,6.18,11.020,24]hexacosa-1(23),2(26),3,5,17::US20260070927, Example 43 Potassium voltage-gated channel subfamily H member 2 Homo sapiens >20000 US Patent 10.7270/Q26978H8 aid1805688 US20260070927 HAN, X; JIANG, M; KOU, B; LIU, H; LIU, Y; SHEN, H; ZHANG, Z; WU, Y; ZHANG, Z; ZHU, W 3/12/2026 7/23/2026 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=796624 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2132&target=Potassium+voltage-gated+channel+subfamily+H+member+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=796624&enzyme=Potassium+voltage-gated+channel+subfamily+H+member+2&column=ki&startPg=0&Increment=50&submit=Search 170444828 528828087 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 8IOB,8IO5,8IO4,5VA2,8ZYQ,8ZYP,8ZYO,8ZYN,7CN1,7CN0,5VA1,9CHS,9CHR,9CHQ,9CHP,5VA3,2L4R,4HQA,2L0W,6SYG,2N7G Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2_HUMAN Q12809 A5H1P7 C4PFH9 D3DX04 O75418 O75680 Q708S9 Q9BT72 Q9BUT7 Q9H3P0 N/A A0A090N8Q0