Compile Data Set for Download or QSAR
Report error Found 229 of affinity data for UniProtKB/TrEMBL: O00222
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074750(LY-389795 | 4-Amino-2-thia-bicyclo[3.1.0]hexane-4,...)
Affinity DataEC50:  7.34E+3nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataEC50:  1.15E+4nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074749(LY379268 | (1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1...)
Affinity DataEC50:  1.69E+3nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50064463(CHEMBL3401177)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation at mGluR8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50064444(CHEMBL3401195)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation at mGluR8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132507(CHEMBL3633943)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu8 receptor (unknown origin) relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074749(LY379268 | (1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1...)
Affinity DataEC50:  1.69E+3nMAssay Description:Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataEC50:  1.15E+4nMAssay Description:Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50202407((-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexa...)
Affinity DataEC50:  4.78E+4nMAssay Description:Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074750(LY-389795 | 4-Amino-2-thia-bicyclo[3.1.0]hexane-4,...)
Affinity DataEC50:  7.34E+3nMAssay Description:Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50202406((-)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50202406((-)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Affinity DataEC50:  3.07E+3nMAssay Description:Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50089518((1R,2R)-1-amino-2-(phosphonomethyl)cyclopropanecar...)
Affinity DataEC50: >3.00E+5nMAssay Description:Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50217030((1S,2S)-1-amino-2-phosphonomethylcyclopropane-carb...)
Affinity DataEC50:  2.15E+3nMAssay Description:Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50089516((1R,2S)-1-amino-2-(phosphonomethyl)cyclopropanecar...)
Affinity DataEC50:  6.51E+3nMAssay Description:Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  560nMAssay Description:Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50217031((1S,2R)-1-amino-2-phosphonomethylcyclopropane-carb...)
Affinity DataEC50:  340nMAssay Description:Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50121643(CHEMBL3616847)
Affinity DataEC50:  1.01E+4nMAssay Description:Agonist activity at human recombinant mGlu8 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50121643(CHEMBL3616847)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu8 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1.5 hrs by FLIPR assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50134443(CHEMBL3746457)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50157910((2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxymeth...)
Affinity DataKd:  6.30nMAssay Description:Dissociation constant of radiolabeled compound against recombinant human Metabotropic glutamate receptor 8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at recombinant human mGlu8 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as induction of forskolin-sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50440185(CHEMBL2426616)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50337526(4-oxochroman-7-yl benzoate | CHEMBL1682821)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM49388(7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one | SMR00...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50337525(7-(phenoxymethyl)chroman-4-one | CHEMBL1682820)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50440205(CHEMBL2426621)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434136(CHEMBL2381640)
Affinity DataEC50:  6.53E+3nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434137(CHEMBL2381649)
Affinity DataEC50:  4.30E+3nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434134(CHEMBL2381641)
Affinity DataEC50:  1.59E+3nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434138(CHEMBL2381651)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434139(CHEMBL2381650)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434140(CHEMBL2381648)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434129(CHEMBL2381647)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434128(CHEMBL2381646)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434133(CHEMBL2381643)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434132(CHEMBL2381642)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50167032((1S,2S,4R,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50167034((1S,2S,4S,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434131(CHEMBL2381644)
Affinity DataEC50:  1.24E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434130(CHEMBL2381645)
Affinity DataEC50:  1.20E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434135(CHEMBL2381652)
Affinity DataEC50:  1.15E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50392432(CHEMBL2151817)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50388941(CHEMBL2063423)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation activity at mGlu8 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu8 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50255291(CHEMBL4060017)
Affinity DataEC50:  4.60E+3nMAssay Description:Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50255333(CHEMBL4082270)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  290nMAssay Description:Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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