Compile Data Set for Download or QSAR
Report error Found 522 of affinity data for UniProtKB/TrEMBL: O60760
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084153(CHEMBL3425948)
Affinity DataKd:  44nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084154(CHEMBL1233897)
Affinity DataKd:  9.5nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084155(CHEMBL3425953)
Affinity DataKd:  50nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084156(CHEMBL3425954)
Affinity DataKd:  60nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084157(CHEMBL3425955)
Affinity DataKd:  300nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084255(CHEMBL3425956)
Affinity DataKd:  200nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084256(CHEMBL3425957)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084257(CHEMBL3425958)
Affinity DataKd: <2.00E+4nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084258(CHEMBL3425959)
Affinity DataKd:  60nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084259(CHEMBL3425960)
Affinity DataKd: <100nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084260(CHEMBL3425961)
Affinity DataKd:  200nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084261(CHEMBL3425962)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084262(CHEMBL3425963)
Affinity DataKd:  400nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084263(CHEMBL3425964)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084264(CHEMBL3425965)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084265(CHEMBL3425966)
Affinity DataKd:  200nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084266(CHEMBL3425967)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084267(CHEMBL3425968)
Affinity DataKd:  400nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084268(CHEMBL3425969)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM21615(1-phenyl-1H-pyrazole-4-carboxylic acid | Pyrazole,...)
Affinity DataKd:  1.40E+5nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084269(CHEMBL3425970)
Affinity DataKd:  800nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084150(CHEMBL3425951)
Affinity DataEC50:  350nMAssay Description:Inhibition HPGDS in human MEG01 cells assessed as reduction in PGD2 production incubated for 30 mins followed by stimulation with 5 uM ionomycin for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM21625(2-phenyl-5-(1H-pyrazol-5-yl)thiazole | 2-phenyl-5-...)
Affinity DataEC50:  110nMAssay Description:Inhibition HPGDS in human MEG01 cells assessed as reduction in PGD2 production incubated for 30 mins followed by stimulation with 5 uM ionomycin for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084152(CHEMBL3425949)
Affinity DataEC50:  74nMAssay Description:Inhibition HPGDS in human MEG01 cells assessed as reduction in PGD2 production incubated for 30 mins followed by stimulation with 5 uM ionomycin for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084153(CHEMBL3425948)
Affinity DataEC50:  130nMAssay Description:Inhibition HPGDS in human MEG01 cells assessed as reduction in PGD2 production incubated for 30 mins followed by stimulation with 5 uM ionomycin for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084154(CHEMBL1233897)
Affinity DataEC50:  35nMAssay Description:Inhibition HPGDS in human MEG01 cells assessed as reduction in PGD2 production incubated for 30 mins followed by stimulation with 5 uM ionomycin for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084150(CHEMBL3425951)
Affinity DataKd:  210nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM21625(2-phenyl-5-(1H-pyrazol-5-yl)thiazole | 2-phenyl-5-...)
Affinity DataKd:  300nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084152(CHEMBL3425949)
Affinity DataKd:  35nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084153(CHEMBL3425948)
Affinity DataKd:  12nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084154(CHEMBL1233897)
Affinity DataKd:  20nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084149(CHEMBL3425952)
Affinity DataKd:  650nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084150(CHEMBL3425951)
Affinity DataKd:  340nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084151(CHEMBL3425950)
Affinity DataKd:  570nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM21625(2-phenyl-5-(1H-pyrazol-5-yl)thiazole | 2-phenyl-5-...)
Affinity DataKd:  51nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084152(CHEMBL3425949)
Affinity DataKd:  23nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50463721(CHEMBL4238290)
Affinity DataKd:  0.140nMAssay Description:Binding affinity to full length recombinant human N-terminal His6-tagged H-PGDS expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataKd:  0.370nMAssay Description:Binding affinity to full length recombinant human N-terminal His6-tagged H-PGDS expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50526485(CHEMBL4473072)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50615780(CHEMBL5285108)
Affinity DataKd:  0.240nMAssay Description:Binding affinity to human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as equilibrium dissociation constant by measuring changes in i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385150(CHEMBL2035650)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of HPGDSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385142(CHEMBL2035651)
Affinity DataIC50: 2.34nMAssay Description:Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50615811(CHEMBL5272869)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50463698(CHEMBL4247050)
Affinity DataIC50: 3nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50615823(CHEMBL5289520)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50615812(CHEMBL5289730)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50615775(CHEMBL5279860)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50615791(CHEMBL5275536)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50615797(CHEMBL5282861)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM179403(US9126973, 8)
Affinity DataIC50: 4nMpH: 8.0 T: 2°CAssay Description:The assay is carried out by the following steps: 1. Inhibitor screening is performed in 100 mM Tris-HCl, pH 8.0 containing 1 mM GSH, 1 mM MgCl.sub.2,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2016
Entry Details
Go to US Patent

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