Compile Data Set for Download or QSAR
Report error Found 1279 of affinity data for UniProtKB/TrEMBL: P15121
LigandChemical structure of BindingDB Monomer ID 16315BDBM16315(CP-744809 | CHEMBL240725 | 6-[(5-chloro-3-methyl-1...)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of Homo sapiens (human) recombinant aldose reductase using D-glyceraldehyde as substrate incubated for 10 min prior to substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16315BDBM16315(CP-744809 | CHEMBL240725 | 6-[(5-chloro-3-methyl-1...)
Affinity DataIC50: 0.840nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16315BDBM16315(CP-744809 | CHEMBL240725 | 6-[(5-chloro-3-methyl-1...)
Affinity DataIC50: 1nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16315BDBM16315(CP-744809 | CHEMBL240725 | 6-[(5-chloro-3-methyl-1...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16314BDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50009806BDBM50009806(CHEMBL20207 | [3-(7-Chloro-benzothiazol-2-ylmethyl...)
Affinity DataIC50: 1nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16315BDBM16315(CP-744809 | CHEMBL240725 | 6-[(5-chloro-3-methyl-1...)
Affinity DataIC50: 1nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16452BDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 1.90nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16452BDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 1.90nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50009763BDBM50009763(CHEMBL20024 | [3-(4-Fluoro-benzothiazol-2-ylmethyl...)
Affinity DataIC50: 2nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50006469BDBM50006469(CHEMBL69956 | [8-Oxo-7-(5-trifluoromethyl-benzothi...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50006469BDBM50006469(CHEMBL69956 | [8-Oxo-7-(5-trifluoromethyl-benzothi...)
Affinity DataIC50: 2.10nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16452BDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human placenta Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16633BDBM16633(6-[(5-fluoro-3-methyl-1-benzofuran-2-)sulfonyl]-2,...)
Affinity DataIC50: 3nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16313BDBM16313(IDD594 | LdT | CHEMBL395347 | {2-[(4-bromo-2-fluor...)
Affinity DataIC50: 3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50009781BDBM50009781(CHEMBL20169 | [3-(5-Bromo-benzothiazol-2-ylmethyl)...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human placenta Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50009781BDBM50009781(CHEMBL20169 | [3-(5-Bromo-benzothiazol-2-ylmethyl)...)
Affinity DataIC50: 3.10nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50009767BDBM50009767(2-(4-oxo-3-((6-(trifluoromethyl)benzo[d]thiazol-2-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16452BDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human placental aldose reductase using glyceraldehyde as substrate in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16452BDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 3.10nMAssay Description:In vitro inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16452BDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16452BDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50006481BDBM50006481(CHEMBL73560 | [1-(5,7-Difluoro-benzothiazol-2-ylme...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50008471BDBM50008471(CHEMBL143234 | [3-(5,7-Difluoro-benzooxazol-2-ylme...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human placenta Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50008471BDBM50008471(CHEMBL143234 | [3-(5,7-Difluoro-benzooxazol-2-ylme...)
Affinity DataIC50: 3.20nMAssay Description:In vitro inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50006475BDBM50006475(CHEMBL71966 | {1-[3-(2,3-Difluoro-phenyl)-[1,2,4]o...)
Affinity DataIC50: 3.30nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50009828BDBM50009828(CHEMBL20015 | [3-(4-Chloro-benzothiazol-2-ylmethyl...)
Affinity DataIC50: 3.5nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50006459BDBM50006459(CHEMBL304995 | [3-(5,7-Difluoro-benzothiazol-2-ylm...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50009784BDBM50009784(CHEMBL278991 | [3-(5,7-Dichloro-benzothiazol-2-ylm...)
Affinity DataIC50: 4nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16452BDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 4nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50006470BDBM50006470(CHEMBL73505 | [5-Chloro-1-(5-fluoro-benzothiazol-2...)
Affinity DataIC50: 4.60nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16452BDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 4.80nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16634BDBM16634(6-{[3-methyl-5-(trifluoromethyl)-1-benzofuran-2-]s...)
Affinity DataIC50: 5nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50009750BDBM50009750(CHEMBL282689 | [3-(4,7-Difluoro-benzothiazol-2-ylm...)
Affinity DataIC50: 5nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16469BDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50009759BDBM50009759(CHEMBL20518 | [3-(5-Chloro-7-fluoro-benzothiazol-2...)
Affinity DataIC50: 5nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50006481BDBM50006481(CHEMBL73560 | [1-(5,7-Difluoro-benzothiazol-2-ylme...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16469BDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 5nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16485BDBM16485(2-{6-methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)
Affinity DataIC50: 5nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50006471BDBM50006471(CHEMBL68580 | [4-Oxo-3-(5-trifluoromethyl-benzothi...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human Aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50006471BDBM50006471(CHEMBL68580 | [4-Oxo-3-(5-trifluoromethyl-benzothi...)
Affinity DataIC50: 5.20nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 228819BDBM228819(Minalrestat (2))
Affinity DataKd:  5.5nMpH: 8.5Assay Description:The anti-His antibody (His Capture Kit, GE Healthcare) was immobilized on sensor chip CM5 (GE Healthcare), in a Biacore T200 or Biacore S200 instrume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50009774BDBM50009774(CHEMBL20161 | [3-(5,7-Dimethyl-benzothiazol-2-ylme...)
Affinity DataIC50: 5.90nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16491BDBM16491(2-{7-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 6nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16239BDBM16239(2-(5-chloro-2-{[(3-nitrophenyl)methyl]carbamoyl}ph...)
Affinity DataIC50: 6nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 16636BDBM16636(6-[(5-chloro-3-ethyl-1-benzofuran-2-)sulfonyl]-2,3...)
Affinity DataIC50: 6nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50612073BDBM50612073(CHEMBL5286261)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant ALR2 expressed in Escherichia coli by Coomassie reagent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50009749BDBM50009749(CHEMBL416001 | [3-(7-Chloro-5-fluoro-benzothiazol-...)
Affinity DataIC50: 6.20nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50506669BDBM50506669(CHEMBL4459307)
Affinity DataKi:  6.20nMAssay Description:Uncompetitive inhibition of human recombinant aldose reductase expressed in Escherichia coli BL21(DE3)pLysS assessed as dissociation constant of enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50009757BDBM50009757(CHEMBL20637 | [3-(5,7-Difluoro-benzothiazol-2-ylme...)
Affinity DataIC50: 6.30nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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