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Report error Found 684 of affinity data for UniProtKB/TrEMBL: P15692
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50003017(CHEMBL3234202)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of VEGF-A production in human HCT116 cells after 12 hrs by alphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50002930(CHEMBL3234200)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of VEGF-A production in human HCT116 cells after 12 hrs by alphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50002918(Apratoxin S4)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of VEGF-A production in human HCT116 cells after 12 hrs by alphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50002932(CHEMBL3234201)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of VEGF-A production in human HCT116 cells after 12 hrs by alphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50307387(8-(4-Phenyl[1,2,3]triazol-1-yl)octyl 2,3,4,6-Tetra...)
Affinity DataKd:  0.620nMAssay Description:Binding affinity to VEGF by surface plasmon-based solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataKd:  0.660nMAssay Description:Binding affinity to human VEGF (13 to 107 residues) expressed in Escherichia coli Rosetta (DE3) cells assessed as dissociation constant at 20 degreeC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50307389(2,3,4,6-Tetra-O-sulfo-alpha-D-mannopyranosyl-(1->3...)
Affinity DataKd:  0.700nMAssay Description:Binding affinity to VEGF by surface plasmon-based solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50307396(12-(4-Naphthalen-1-yl[1,2,3]triazol-1-yl)dodecyl 2...)
Affinity DataKd:  0.790nMAssay Description:Binding affinity to VEGF by surface plasmon-based solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM372992(US9896418, Compound 64 | US10597366, Compound 64)
Affinity DataEC50:  1nMAssay Description:VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM372992(US9896418, Compound 64 | US10597366, Compound 64)
Affinity DataEC50:  1nMAssay Description:About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM372992(US9896418, Compound 64 | US10597366, Compound 64)
Affinity DataEC50:  1nMAssay Description:Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50307392(3-(4-Phenyl[1,2,3]triazol-1-yl)propyl 2,3,4,6-Tetr...)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to VEGF by surface plasmon-based solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50307400(hexadecasodium [3-({4-[(4-{[3,5-bis(sulfonatooxy)-...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to VEGF by surface plasmon-based solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50179253((2R,3S,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-2-{[(2R,3S,4...)
Affinity DataKd:  1.70nMAssay Description:Binding affinity for VEGF by BIAcore solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50179254((2R,3S,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-2-{[(2R,3S,4...)
Affinity DataKd:  1.70nMAssay Description:Binding affinity for VEGF by BIAcore solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50307398(Hexadecasodium [2-(benzyloxy)-3-({4-[(4-{[3,5-bis(...)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to VEGF by surface plasmon-based solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282581(US9884843, Compound 9 | 4-Bromo-5-(3-chloro-5-fluo...)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM566629(3-fluoro-5-(((1R,2S,2aS)-1,2,3,3,4,4-hexafluoro- 2...)
Affinity DataEC50:  2nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50378647(PI-88 | CHEMBL1627122)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to VEGF by surface plasmon-based solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM717837(US20250042853, Example 3)
Affinity DataIC50: 3nMAssay Description:786-O cells in the logarithmic growth phase were inoculated into a 96-well plate at a cell concentration of 65,000 cells per ml of culture liquid, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM694234(7-(difluoromethyl)-6-(3,5-difluorophenoxy)-2,2,3,3...)
Affinity DataEC50:  4nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2alpha was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM373015(US9896418, Compound 185 | US10597366, Compound 185)
Affinity DataEC50:  4nMAssay Description:About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM373015(US9896418, Compound 185 | US10597366, Compound 185)
Affinity DataEC50:  4nMAssay Description:Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM694226(US12077506, Compound I-la | US12077506, Compound I...)
Affinity DataEC50:  4nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2alpha was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM373015(US9896418, Compound 185 | US10597366, Compound 185)
Affinity DataEC50:  4nMAssay Description:VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282632(US9884843, Compound 25 | 5-(3-Chloro-5-fluoropheno...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282713(US9884843, Compound 57 | (R)-4-Bromo-5-(3-chloro-5...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282682(US9884843, Compound 26 | 3-((3-Amino-4-(difluorome...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282686(US9884843, Compound 30)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282632(US9884843, Compound 25 | 5-(3-Chloro-5-fluoropheno...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282634(US9884843, Compound 19 | 3-Amino-4-(difluoromethyl...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282656(US9884843, Compound 22 | 4-(Difluoromethyl)-5-(3,5...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282761(US9884843, Compound 105 | 5-(3-cyano-5-fluoro-phen...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282584(US9884843, Compound 11 | 4-Chloro-5-(3-chloro-5-fl...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282572((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282598(US9884843, Compound 14 | 5-(3-Chloro-5-fluoropheno...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282702(US9884843, Compound 46 | (R)-3-((4-(Difluoromethyl...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282689(US9884843, Compound 33)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM282572((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50307395(12-(4-Phenyl[1,2,3]triazol-1-yl)dodecyl 2,3,4,6-Te...)
Affinity DataKd:  5.10nMAssay Description:Binding affinity to VEGF by surface plasmon-based solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 5.27nMAssay Description:Inhibition of VEGF-stimulated VEGFR-2 autophosphorylation in intact cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM566616(US11420936, Compound 21 | 3-fluoro-5-(((1S,2aR)-1,...)
Affinity DataEC50:  6nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM373004(US9896418, Compound 158 | US10597366, Compound 158)
Affinity DataEC50:  6nMAssay Description:VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM372966(US9896418, Compound 9 | US10597366, Compound 9)
Affinity DataEC50:  6nMAssay Description:Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM694223(US12077506, Compound I-1 | 3-((4-(difluoromethyl)-...)
Affinity DataEC50:  6nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2alpha was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM372966(US9896418, Compound 9 | US10597366, Compound 9)
Affinity DataEC50:  6nMAssay Description:About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM694226(US12077506, Compound I-la | US12077506, Compound I...)
Affinity DataEC50:  6nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2alpha was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM566616(US11420936, Compound 21 | 3-fluoro-5-(((1S,2aR)-1,...)
Affinity DataEC50:  6nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM373004(US9896418, Compound 158 | US10597366, Compound 158)
Affinity DataEC50:  6nMAssay Description:About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM372966(US9896418, Compound 9 | US10597366, Compound 9)
Affinity DataEC50:  6nMAssay Description:VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

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