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TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50138191(ONO-1714 | (1S,5S,6R,7R)-7-Chloro-5-methyl-2-aza-b...)
Affinity DataKi:  18nMAssay Description:Inhibition of human eNOS overexpressed in baculovirus infected Sf21 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50386178(ONO-1714 | CHEMBL1800346)
Affinity DataKi:  18.6nMAssay Description:Inhibition of human eNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50271827(S-ISOPROPYL-ISOTHIOUREA | 2-Isopropyl-isothiourea ...)
Affinity DataKi:  22nMAssay Description:Inhibition of eNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626248(CHEMBL106871)
Affinity DataKi:  24nMAssay Description:Inhibition of human eNOS assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50225106(NG-nitroarginine | 2-Amino-5-(N'-nitro-guanidino)-...)
Affinity DataKi:  30nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091817(CHEMBL302657 | 4-Methyl-6-propylpyridin-2-amine, 7...)
Affinity DataIC50: 34nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50055281(2-Ethyl-isothiourea | S-ethyl-iso-thiourea | S-ETH...)
Affinity DataKi:  39nMAssay Description:Inhibition of eNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | CHEMBL59925 | CHEMB...)
Affinity DataIC50: 44.7nMAssay Description:Inhibition of human eNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | CHEMBL59925 | CHEMB...)
Affinity DataIC50: 45nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091792(6-Ethyl-4-methyl-pyridin-2-ylamine | CHEMBL294084)
Affinity DataIC50: 49nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091817(CHEMBL302657 | 4-Methyl-6-propylpyridin-2-amine, 7...)
Affinity DataIC50: 50nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50098962(5-Cyclopropyl-4,5-dihydro-thieno[2,3-c]pyridin-7-y...)
Affinity DataIC50: 50nMAssay Description:Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by e-NOS from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091800(4-METHYLPYRIDIN-2-AMINE, 6 | 4-METHYLPYRIDIN-2-AMI...)
Affinity DataIC50: 72nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50098959(5-Ethynyl-4,5-dihydro-thieno[2,3-c]pyridin-7-ylami...)
Affinity DataIC50: 80nMAssay Description:Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by e-NOS from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM36401(CID24894153 | (2S)-2-Methyl-2,3-dihydrothieno[2,3-...)
Affinity DataIC50: 80nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091791(4-Methyl-pyridine-2,3-diamine | CHEMBL61427)
Affinity DataIC50: 81nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091800(4-METHYLPYRIDIN-2-AMINE, 6 | 4-METHYLPYRIDIN-2-AMI...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50098951(6-Ethynyl-6,7-dihydro-thieno[3,2-c]pyridin-4-ylami...)
Affinity DataIC50: 120nMAssay Description:Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by e-NOS from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50062133(4-Methyl-piperidin-(2Z)-ylideneamine | 4-Methyl-pi...)
Affinity DataIC50: 146nMAssay Description:Inhibitory activity against human Endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091801(6-Isobutyl-4-methyl-pyridin-2-ylamine | 6-isobutyl...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human eNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091801(6-Isobutyl-4-methyl-pyridin-2-ylamine | 6-isobutyl...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091809(3,4-Dimethyl-pyridin-2-ylamine | CHEMBL61939)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50098940(8-Fluoro-3-(4-fluoro-phenyl)-3,4-dihydro-isoquinol...)
Affinity DataIC50: 160nMAssay Description:Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | CHEMBL59925 | CHEMB...)
Affinity DataIC50: 170nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50124519(5,8-Difluoro-2-furan-2-yl-1,2-dihydro-quinazolin-4...)
Affinity DataIC50: 180nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50372207(CHEMBL272708)
Affinity DataIC50: 180nMAssay Description:Inhibition of human eNOS expressed in insect SF9 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM36402(CID24894154 | (3R)-3-Propyl-2,3-dihydrothieno[2,3-...)
Affinity DataIC50: 200nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50392587(CHEMBL1230023)
Affinity DataIC50: 200nMAssay Description:Inhibition of wild type human eNOS using L-Arg as substrate incubated for 1 hr prior to L-Arg additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091798(6-Isopropyl-4-methyl-pyridin-2-ylamine | CHEMBL299...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50372223(CHEMBL428069)
Affinity DataIC50: 220nMAssay Description:Inhibition of human eNOS expressed in insect SF9 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50062133(4-Methyl-piperidin-(2Z)-ylideneamine | 4-Methyl-pi...)
Affinity DataIC50: 220nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50116666(CHEMBL76342 | CHEMBL75304 | 4-Methyl-3,6-dihydro-1...)
Affinity DataIC50: 230nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091813(4-ethylpyridin-2-amine | 4-Ethyl-pyridin-2-ylamine...)
Affinity DataIC50: 230nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50116676(4,6-Dimethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneam...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50346529(CHEMBL1783095 | CHEMBL1783094 | (R)-azetidine-2-ca...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant eNOS by microtiter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50289680(2-Amino-3-(2-guanidino-phenyl)-propionic acid | CH...)
Affinity DataKi:  250nMAssay Description:Inhibitory constant for the inhibition of human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50289681(2-Amino-3-[2-(N'-methyl-guanidino)-phenyl]-propion...)
Affinity DataKi:  270nMAssay Description:Inhibitory constant for the inhibition of human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50098963(4,5-Dihydro-thieno[2,3-c]pyridin-7-ylamine | CHEMB...)
Affinity DataIC50: 280nMAssay Description:Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by e-NOS from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50230993(CHEMBL256147 | 2-Amino-5-(N'-methyl-guanidino)-pen...)
Affinity DataIC50: 300nMAssay Description:Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091800(4-METHYLPYRIDIN-2-AMINE, 6 | 4-METHYLPYRIDIN-2-AMI...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50230993(CHEMBL256147 | 2-Amino-5-(N'-methyl-guanidino)-pen...)
Affinity DataIC50: 300nMAssay Description:Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by e-NOS from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50062142(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)
Affinity DataIC50: 300nMAssay Description:inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50116673(3,4-Dimethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneam...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50225106(NG-nitroarginine | 2-Amino-5-(N'-nitro-guanidino)-...)
Affinity DataIC50: 320nMAssay Description:In vitro inhibition of endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50065823(N-(3-Aminomethyl-phenyl)-2-methylsulfanyl-acetamid...)
Affinity DataKi:  320nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50225106(NG-nitroarginine | 2-Amino-5-(N'-nitro-guanidino)-...)
Affinity DataIC50: 320nMAssay Description:Inhibitory concentration against recombinant human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091800(4-METHYLPYRIDIN-2-AMINE, 6 | 4-METHYLPYRIDIN-2-AMI...)
Affinity DataIC50: 320nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50030279(2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | C...)
Affinity DataIC50: 330nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50065807(N-(3-Aminomethyl-phenyl)-furan-2-carboxamidine | C...)
Affinity DataKi:  350nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50095181(N-(3-Aminomethyl-phenyl)-furan-2-carboxamidine | C...)
Affinity DataKi:  350nMAssay Description:Inhibition of human eNOS assessed as reduction of L-[14C]arginine to L-[14C]-citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
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