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TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424409BDBM424409(US10508120, Compound I-922 | US10508120, Compound ...)
Affinity DataKd:  0.00100nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424440BDBM424440(US10508120, Compound I-1074 | US10508120, Compound...)
Affinity DataKd:  0.00100nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 565685BDBM565685(US11414431, Compound I-253 | US12221453, Compound ...)
Affinity DataKd:  0.00200nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424362BDBM424362(US10508120, Compound I-817 | US10508120, Compound ...)
Affinity DataKd:  0.00200nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 565687BDBM565687(US11414431, Compound I-255 | US12221453, Compound ...)
Affinity DataKd:  0.00200nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632579BDBM50632579(CHEMBL5424894)
Affinity DataKd:  0.00200nMAssay Description:Binding affinity to TYK2 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424815BDBM424815(US10508120, Compound I-1319 | US10577373, Compound...)
Affinity DataKd:  0.00200nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632583BDBM50632583(CHEMBL5403297)
Affinity DataKd:  0.00200nMAssay Description:Binding affinity to TYK2 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424435BDBM424435(US10508120, Compound I-975 | US10508120, Compound ...)
Affinity DataKd:  0.00200nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424662BDBM424662(US10508120, Compound I-1117 | US10577373, Compound...)
Affinity DataKd:  0.00300nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424408BDBM424408(US10508120, Compound I-904 | US10508120, Compound ...)
Affinity DataKd:  0.00300nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424361BDBM424361(US10508120, Compound I-816 | US10508120, Compound ...)
Affinity DataKd:  0.00300nMAssay Description:Binding affinity to TYK2 JH2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424408BDBM424408(US10508120, Compound I-904 | US10508120, Compound ...)
Affinity DataKd:  0.00300nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424448BDBM424448(US10508120, Compound I-903 | US10577373, Compound ...)
Affinity DataKd:  0.00400nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618789BDBM50618789(CHEMBL5438635)
Affinity DataKd:  0.00400nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424559BDBM424559(US10508120, Compound I-1353 | US10508120, Compound...)
Affinity DataKd:  0.00400nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424361BDBM424361(US10508120, Compound I-816 | US10508120, Compound ...)
Affinity DataKd:  0.00400nMAssay Description:Binding affinity to human wild-type partial length TYK2 JH2 (G556 to D888 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424454BDBM424454(US10508120, Compound I-1183 | US10508120, Compound...)
Affinity DataKd:  0.00400nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424525BDBM424525(US10508120, Compound I-980 | US10577373, Compound ...)
Affinity DataKd:  0.00400nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632576BDBM50632576(CHEMBL5439447)
Affinity DataKd:  0.00500nMAssay Description:Binding affinity to human wild-type partial length TYK2 JH2 (G556 to D888 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424893BDBM424893(US10508120, Compound I-1397 | US10577373, Compound...)
Affinity DataKd:  0.00500nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Accro Bioscience (HK)

US Patent
LigandChemical structure of BindingDB Monomer ID 701135BDBM701135(US20240343747, Example B39)
Affinity DataKd:  0.00600nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424422BDBM424422(US10508120, Compound I-877 | US10577373, Compound ...)
Affinity DataKd:  0.00600nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 565683BDBM565683(US11414431, Compound I-251 | US12221453, Compound ...)
Affinity DataKd:  0.00600nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424529BDBM424529(US10508120, Compound I-1084 | US10508120, Compound...)
Affinity DataKd:  0.00600nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424220BDBM424220(US10508120, Compound I-675 | US10508120, Compound ...)
Affinity DataKd:  0.00700nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 565754BDBM565754(US11414431, Compound I-322 | US12221453, Compound ...)
Affinity DataKd:  0.00800nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Accro Bioscience (HK)

US Patent
LigandChemical structure of BindingDB Monomer ID 701134BDBM701134(US20240343747, Example B38)
Affinity DataKd:  0.00800nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50507816BDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataKd:  0.00800nMAssay Description:Binding affinity to TYK2 JH2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632578BDBM50632578(CHEMBL5416592)
Affinity DataKd:  0.00800nMAssay Description:Binding affinity to human wild-type partial length TYK2 JH2 (G556 to D888 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632577BDBM50632577(CHEMBL5436959)
Affinity DataKd:  0.00900nMAssay Description:Binding affinity to human wild-type partial length TYK2 JH2 (G556 to D888 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628089BDBM50628089(CHEMBL5427107)
Affinity DataIC50: 0.0100nMAssay Description:Displacement of fluorescein-labeled kinase tracer from His-TVMV-TYK2 JH2 (575 to 869 residues) (unknown origin) measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Accro Bioscience (HK)

US Patent
LigandChemical structure of BindingDB Monomer ID 701128BDBM701128(US20240343747, Example B29)
Affinity DataKd:  0.0100nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Accro Bioscience (HK)

US Patent
LigandChemical structure of BindingDB Monomer ID 701136BDBM701136(US20240343747, Example B41)
Affinity DataKd:  0.0140nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526620BDBM50526620(CHEMBL4460368)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Accro Bioscience (HK)

US Patent
LigandChemical structure of BindingDB Monomer ID 701124BDBM701124(US20240343747, Example B11)
Affinity DataKd:  0.0160nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632588BDBM50632588(CHEMBL5427277)
Affinity DataIC50: 0.0160nMAssay Description:Inhibition of TYK2 JH2 (561 to 860 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595843BDBM50595843(CHEMBL5191508)
Affinity DataKd: <0.0170nMAssay Description:Binding affinity to T7-tagged TYK2 JH2 (unknown origin) expressed in Escherichia coli BL21 cells incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632592BDBM50632592(CHEMBL5422022)
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of TYK2 JH2 (561 to 860 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526622BDBM50526622(CHEMBL4442827)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50627870BDBM50627870(CHEMBL5424497)
Affinity DataKd:  0.0190nMAssay Description:Binding affinity to human recombinant TYK2 (556 to 871 residues) incubated for 10 hrs by microplate reader based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424111BDBM424111(US10508120, Compound I-572 | US10577373, Compound ...)
Affinity DataKd:  0.0190nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50507816BDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of TYK2 in human Jurkat cells assessed as reduction in IFN-alpha stimulated TYK2 phosphorylation by caspase3/7 reagent-based Western blot ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50507816BDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to TYK2 pseudokinase domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565986BDBM50565986(CHEMBL4789639)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of TYK2 JH2 domain (unknown origin) by HTRF assay based Morrison titration analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50507816BDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of fluorescein labeled probe binding to His-tagged human TYK2 pseudokinase domain (575-869 residues) by Morrison titration based HTRF assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 424808BDBM424808(US10508120, Compound I-1413 | US10508120, Compound...)
Affinity DataKd:  0.0230nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526613BDBM50526613(CHEMBL4571920)
Affinity DataKi:  0.0240nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Accro Bioscience (HK)

US Patent
LigandChemical structure of BindingDB Monomer ID 701132BDBM701132(US20240343747, Example B35)
Affinity DataKd:  0.0250nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Accro Bioscience (HK)

US Patent
LigandChemical structure of BindingDB Monomer ID 701129BDBM701129(US20240343747, Example B32)
Affinity DataKd:  0.0250nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

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