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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0720nMAssay Description:Binding affinity against nicotinic acetylcholine receptor alpha4-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-4(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0910nMAssay Description:Binding affinity against nicotinic acetylcholine receptor alpha2-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK243 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50329477((S)-N-(3-(4-(3-aminopropylamino)butylamino)propyl)...)
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Human)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567433(CHEMBL4869892)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]epibatidine from alpha3beta4 nAChR (unknown origin) expressed in HEK cell membranes after 4 hrs by liquid scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Human)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567430(CHEMBL4860756)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Human)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567432(CHEMBL4876825)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to alpha3beta4 nACh receptor (unknown origin) expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKd:  0.300nMAssay Description:Dissociation constant against Nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515186(CHEMBL4462550)
Affinity DataIC50: 0.350nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515196(CHEMBL4454232)
Affinity DataIC50: 0.370nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Human)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567431(CHEMBL4878931)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.457nMAssay Description:Binding affinity against nicotinic acetylcholine receptor alpha3-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515192(CHEMBL4556075)
Affinity DataIC50: 0.460nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515195(CHEMBL4443845)
Affinity DataIC50: 0.550nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515185(CHEMBL4585225)
Affinity DataIC50: 0.570nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515189(CHEMBL4463134)
Affinity DataIC50: 0.650nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406472(CHEMBL4163848)
Affinity DataKi:  0.684nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-4(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50170586((3S)-3-{[(2S)-1-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2...)
Affinity DataIC50: 0.75nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4; Range is 0.3-1.5 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406641(CHEMBL4170527)
Affinity DataKi:  0.799nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406541(CHEMBL4163257)
Affinity DataKi:  0.818nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515188(CHEMBL4531333)
Affinity DataIC50: 0.920nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515187(CHEMBL425006)
Affinity DataIC50: 0.930nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515190(CHEMBL4440025)
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406792(CHEMBL4174509)
Affinity DataKi:  0.988nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406686(CHEMBL4167298)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515194(CHEMBL4559471)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406544(CHEMBL4174940)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406500(CHEMBL4166573)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406685(CHEMBL4164252)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515193(CHEMBL4518954)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Human)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567427(CHEMBL4872474)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Human)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50587092(CHEMBL5087554)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at rat alpha6/alpha3beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-4(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50170592(CHEMBL411146)
Affinity DataIC50: 1.5nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4; Range is 0.3-1.5 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Human)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM86240(Gly-L-Cys(1)-L-Cys(2)-L-Ser-L-Asn-L-Pro-L-Val-L-Cy...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515191(CHEMBL371789)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Human)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50516314(CHEMBL4462168)
Affinity DataIC50: 2nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Human)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567426(CHEMBL4878856)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Human)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50516340(CHEMBL4439678)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406539(CHEMBL4175573)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50329475((S)-N-(1-(3-(4-(3-aminopropylamino)butylamino)prop...)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50534298(CHEMBL4438684)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50001695(CHEMBL3238085)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-evoked current by voltag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50534286(CHEMBL4453542)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50329474((S)-N-(1-(3-(4-(3-aminopropylamino)butylamino)prop...)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50329473((S)-N-(1-(3-(4-(3-aminopropylamino)butylamino)prop...)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50534287(CHEMBL4519018)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to alpha3beta4 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
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