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Report error Found 3809 of affinity data for UniProtKB/TrEMBL: P41146
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi:  0.00130nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50475328(CHEMBL414782)
Affinity DataKi:  0.00500nMAssay Description:Receptor binding affinity for recombinant human N/OFQ peptide receptor (NOP) expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50475327(CHEMBL410653)
Affinity DataKi:  0.00700nMAssay Description:Receptor binding affinity for recombinant human N/OFQ peptide receptor (NOP) expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50475330(CHEMBL442297)
Affinity DataKi:  0.0200nMAssay Description:Receptor binding affinity for recombinant human N/OFQ peptide receptor (NOP) expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50121249(F-G-G-F-T-G-A-R-K-S-A-R-K-L-Aib-N-Q-CONH2 | CHEMBL...)
Affinity DataKi:  0.0200nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM86660(OFQ/N UFP-102)
Affinity DataKi:  0.0210nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50475333(CHEMBL264846)
Affinity DataKi:  0.0220nMAssay Description:Receptor binding affinity for recombinant human N/OFQ peptide receptor (NOP) expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50475331(CHEMBL411649)
Affinity DataKi:  0.0250nMAssay Description:Receptor binding affinity for recombinant human N/OFQ peptide receptor (NOP) expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50255899(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3...)
Affinity DataEC50:  0.0251nMAssay Description:Agonist activity at human NOPR expressed in human BHK cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by radioimmu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM21864(NALTRINDOLE | (8R)-7-(cyclopropylmethyl)-5,6,7,8,1...)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity against delta-opioid receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50475325(CHEMBL262544)
Affinity DataKi:  0.0320nMAssay Description:Receptor binding affinity for recombinant human N/OFQ peptide receptor (NOP) expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50103533(CHEMBL3343947)
Affinity DataIC50: 0.0330nMAssay Description:Displacement of [3H]]nociceptin from human ORL1 receptor high affinity binding site expressed in African green monkey COS7 cells after 90 mins by top...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50420815(CHEMBL2088054)
Affinity DataKi:  0.0373nMAssay Description:Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50173133(CHEMBL3810319)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]OFQ/nociceptin from human nociceptin receptor expressed in CHO cell membrane incubated for 60 mins by liquid scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2017
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50190307(Ac-RYYRIK-GGG-K-(NH2)-YAFGYPS-GG | CHEMBL414736)
Affinity DataIC50: 0.0464nMAssay Description:Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50475329(CHEMBL263588)
Affinity DataKi:  0.0480nMAssay Description:Receptor binding affinity for recombinant human N/OFQ peptide receptor (NOP) expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi:  0.0490nMAssay Description:Binding affinity for recombinant human N/OFQ peptide receptor (NOP) expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50121247(F-G-G-F-T-G-Aib-R-K-S-A-R-K-L-A-N-Q-CONH2 | CHEMBL...)
Affinity DataKi:  0.0500nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50121245(F-G-G-F-T-G-Aib-R-K-S-Aib-R-K-L-A-N-Q-CONH2 | CHEM...)
Affinity DataKi:  0.0500nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50173132(CHEMBL3808650)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]OFQ/nociceptin from human nociceptin receptor expressed in CHO cell membrane incubated for 60 mins by liquid scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2017
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50103534(CHEMBL3343949)
Affinity DataIC50: 0.0590nMAssay Description:Displacement of [3H]]nociceptin from human ORL1 receptor high affinity binding site expressed in African green monkey COS7 cells after 90 mins by top...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM21842(OFQ 1-17 | N/OFQ | (2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-...)
Affinity DataKi:  0.0600nMAssay Description:Ability to displace [125I]-Tyr14 at nociceptin (NOP) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50121246(F-G-G-F-T-G-A-R-K-S-A-R-K-L-MeA-N-Q-CONH2 | CHEMBL...)
Affinity DataKi:  0.0600nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50121247(F-G-G-F-T-G-Aib-R-K-S-A-R-K-L-A-N-Q-CONH2 | CHEMBL...)
Affinity DataEC50:  0.0600nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004193(CHEMBL3236476)
Affinity DataKi:  0.0648nMAssay Description:Displacement of [3H]-nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50475333(CHEMBL264846)
Affinity DataEC50:  0.0661nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50420812(CHEMBL2088061)
Affinity DataKi:  0.0672nMAssay Description:Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50475328(CHEMBL414782)
Affinity DataEC50:  0.0676nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM86660(OFQ/N UFP-102)
Affinity DataKi:  0.0680nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004180(CHEMBL3236474)
Affinity DataKi:  0.0711nMAssay Description:Displacement of [3H]-nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50475328(CHEMBL414782)
Affinity DataEC50:  0.0759nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM86660(OFQ/N UFP-102)
Affinity DataKi:  0.0760nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50121253(F-G-G-F-T-G-A-R-K-S-Aib-R-K-L-A-N-Q-CONH2 | CHEMBL...)
Affinity DataKi:  0.0800nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM21842(OFQ 1-17 | N/OFQ | (2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-...)
Affinity DataEC50:  0.0800nMAssay Description:Compound was evaluated for increase in [35S]GTP-gamma-S, binding for human ORL1 receptor carried out in CHO cell membranes; Nd: no dataMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50121245(F-G-G-F-T-G-Aib-R-K-S-Aib-R-K-L-A-N-Q-CONH2 | CHEM...)
Affinity DataEC50:  0.0800nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50190308(Ac-RYYRIK-GGG-K-(NH2)-YRFB-GGGGG | CHEMBL441930)
Affinity DataIC50: 0.0803nMAssay Description:Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataIC50: 0.0840nMAssay Description:Displacement of [3H]]isoVa-RYYRIK-NH2 from human ORL1 receptor high affinity binding site expressed in African green monkey COS7 cells after 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50255850(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3...)
Affinity DataKi:  0.0858nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50546920(CHEMBL4781235)
Affinity DataEC50:  0.0871nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50420804(CHEMBL2088055)
Affinity DataKi:  0.0892nMAssay Description:Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50400876(CHEMBL2204347)
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  0.0900nMAssay Description:Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50400866(CHEMBL2204348)
Affinity DataKi:  0.0902nMAssay Description:Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004195(CHEMBL3236478)
Affinity DataKi:  0.0908nMAssay Description:Displacement of [3H]-nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004175(CHEMBL3236486)
Affinity DataKi:  0.0916nMAssay Description:Displacement of [3H]-nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50333104(H-FGGFTGARKSARKLANQ-NH2 | N/OFQ-NH2 | NC(1-17)NH2 ...)
Affinity DataKd:  0.0920nMAssay Description:Binding affinity to recombinant ORL1 receptor expressed in COS7 cells by saturation binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004196(CHEMBL3236479)
Affinity DataKi:  0.0939nMAssay Description:Displacement of [3H]-nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004181(CHEMBL3236475)
Affinity DataKi:  0.0954nMAssay Description:Displacement of [3H]-nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50004174(CHEMBL3236485)
Affinity DataKi:  0.0970nMAssay Description:Displacement of [3H]-nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
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