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Report error Found 7373 of affinity data for UniProtKB/TrEMBL: P43490
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 81396BDBM81396(GMX1778)
Affinity DataIC50: 0.0700nMAssay Description:In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543064BDBM543064(3-(4-{[2-methoxy-5- (trifluoromethyl)phenyl]sulfam...)
Affinity DataIC50: 0.100nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 81395BDBM81395(APO-866 | US20240327418, Example FK866 | US2024030...)
Affinity DataIC50: 0.140nMAssay Description:In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50625739BDBM50625739(CHEMBL5429026)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of recombinant human NAMPT preincubated for 5 mins followed by NAM addition measured for 15 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 81395BDBM81395(APO-866 | US20240327418, Example FK866 | US2024030...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of recombinant human NAMPT preincubated for 5 mins followed by NAM addition measured for 15 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50532342BDBM50532342(CHEMBL4544378)
Affinity DataIC50: 0.155nMAssay Description:Inhibition of NAMPT in human MCF7 cells assessed as decrease in NAD production after 24 hrs by NAD/NADH Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50532342BDBM50532342(CHEMBL4544378)
Affinity DataIC50: 0.155nMAssay Description:Inhibition of NAMPT in human MCF7 cells assessed as decrease in NAD production after 24 hrs by NAD/NADH Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50625738BDBM50625738(CHEMBL5437893)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of recombinant human NAMPT preincubated for 5 mins followed by NAM addition measured for 15 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 81393BDBM81393(MPI-0479883)
Affinity DataIC50: 0.170nMAssay Description:In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50011178BDBM50011178(CHEMBL3260316)
Affinity DataIC50: 0.174nMAssay Description:Inhibition of recombinant human C-terminally His-tagged NAMPT by TR-FRET assay in presence of PRPPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50011178BDBM50011178(CHEMBL3260316)
Affinity DataIC50: 0.174nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50443803BDBM50443803(CHEMBL3094250)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of NAMPT in human HepG2 cells using [14C]-nicotinamide/PRPP as substrate assessed as formation of [14C]-nicotinamide mononucleotide after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 81393BDBM81393(MPI-0479883)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of N-terminal 6His-tagged human NAMPT expressed in Escherichia coli BL21 (DE3) measured for 1 hr by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50439676BDBM50439676(CHEMBL2417796)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50117198BDBM50117198(CHEMBL123756 | MPI-0479626 | 4-{[7-Chloro-3-methyl...)
Affinity DataIC50: 0.230nMAssay Description:In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543083BDBM543083(3-(pyridin-3-ylmethyl)-1-{4-[(5,6,7,8- tetrahydron...)
Affinity DataIC50: 0.300nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543116BDBM543116(3-{4-[(2-chloro-5- methylphenyl)sulfamoyl]phenyl}-...)
Affinity DataIC50: 0.300nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 81395BDBM81395(APO-866 | US20240327418, Example FK866 | US2024030...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to NAMPT (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 81395BDBM81395(APO-866 | US20240327418, Example FK866 | US2024030...)
Affinity DataKi:  0.300nMAssay Description:Noncompetitive inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50347432BDBM50347432(CHEMBL1801863)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 81395BDBM81395(APO-866 | US20240327418, Example FK866 | US2024030...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of NAMPT (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50347432BDBM50347432(CHEMBL1801863)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50443800BDBM50443800(CHEMBL3094255)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of NAMPT in human HepG2 cells using [14C]-nicotinamide/PRPP as substrate assessed as formation of [14C]-nicotinamide mononucleotide after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50117198BDBM50117198(CHEMBL123756 | MPI-0479626 | 4-{[7-Chloro-3-methyl...)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50202721BDBM50202721(CHEMBL3968268 | US10730889, Example 399 | US114857...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of NAMPT in human A2780 cells assessed as decrease in cell viability after 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2018
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50011179BDBM50011179(CHEMBL3260317)
Affinity DataIC50: 0.412nMAssay Description:Inhibition of recombinant human C-terminally His-tagged NAMPT by TR-FRET assay in presence of PRPPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50347433BDBM50347433(CHEMBL1801864)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50347433BDBM50347433(CHEMBL1801864)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50011176BDBM50011176(CHEMBL3260314)
Affinity DataIC50: 0.461nMAssay Description:Inhibition of recombinant human C-terminally His-tagged NAMPT by TR-FRET assay in presence of PRPPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543293BDBM543293(1-[4-(1H-indole-7-sulfonyl)phenyl]-3-(pyridin- 3-y...)
Affinity DataIC50: 0.5nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50347433BDBM50347433(CHEMBL1801864)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human Nampt after 3 hrs by counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50347427BDBM50347427(CHEMBL1801934)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 81395BDBM81395(APO-866 | US20240327418, Example FK866 | US2024030...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50202656BDBM50202656(CHEMBL3916438 | US10730889, Example 419 | US114857...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of NAMPT in human A2780 cells assessed as decrease in cell viability after 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2018
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543060BDBM543060(3-(4-{[2- (difluoromethoxy)phenyl]sulfamoyl}phenyl...)
Affinity DataIC50: 0.600nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50444655BDBM50444655(CHEMBL3098518)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of Nampt (unknown origin) using nicotinamide as substrate preincubated for 15 mins measured after 30 mins by mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50011177BDBM50011177(CHEMBL3260315)
Affinity DataIC50: 0.632nMAssay Description:Inhibition of recombinant human C-terminally His-tagged NAMPT by TR-FRET assay in presence of PRPPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543328BDBM543328(3-(4-{[3-fluoro-5-(trifluoromethyl)benzene]sulfony...)
Affinity DataIC50: 0.700nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 50347431BDBM50347431(CHEMBL1801862)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543036BDBM543036(1-[4-(dibenzylsulfamoyl)phenyl]-3-(pyridin-3- ylme...)
Affinity DataIC50: 0.800nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543121BDBM543121(3-{4-[(2-iodophenyl)sulfamoyl]phenyl}-1- (pyridin-...)
Affinity DataIC50: 0.800nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 180912BDBM180912(US9676721, 28 2-cyano-1-({4-[(3,4-difluorobenzene)...)
Affinity DataIC50: 0.800nMpH: 7.5 T: 2°CAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 217311BDBM217311(US9302989, 1552)
Affinity DataIC50: 0.860nMpH: 7.5Assay Description:Probe 2:The assay was carried out in 18 uL low volume plates (Owens Corning) in reaction buffer (50 mM HEPES (NaOH), pH 7.5, 100 mM NaCl, 10 mM MgCl2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2017
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543114BDBM543114(3-{4-[(2-chloro-4- fluorophenyl)sulfamoyl]phenyl}-...)
Affinity DataIC50: 0.900nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543165BDBM543165(3-{4-[benzyl(ethyl)sulfamoyl]phenyl}-1- (pyridin-3...)
Affinity DataIC50: 0.900nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543149BDBM543149(3-{4-[(5-chloro-2- methoxyphenyl)sulfamoyl]phenyl}...)
Affinity DataIC50: 0.900nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543359BDBM543359(3-{4-[(3-chloro-4- methylbenzene)sulfonyl]phenyl}-...)
Affinity DataIC50: 0.900nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 543108BDBM543108(3-{4-[(2,3-dimethylphenyl)sulfamoyl]phenyl}- 1-(py...)
Affinity DataIC50: 0.900nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 252532BDBM252532(US9458172, 135 | US9458172, 113)
Affinity DataIC50: 0.916nMpH: 7.5Assay Description:The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandChemical structure of BindingDB Monomer ID 217130BDBM217130(US9302989, 451)
Affinity DataIC50: 0.946nMpH: 7.5Assay Description:Probe 1:The assay was carried out in 18 uL low volume plates (Owens Corning) in reaction buffer (50 mM HEPES (NaOH), pH 7.5, 100 mM NaCl, 10 mM MgCl2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2017
Entry Details
US Patent

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