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TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589394(CHEMBL4797564)
Affinity DataKd:  0.0960nMAssay Description:Binding affinity to CLK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589394(CHEMBL4797564)
Affinity DataIC50: 0.0960nMAssay Description:Inhibition of human CLK2 administered orallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589394(CHEMBL4797564)
Affinity DataKd:  0.0960nMAssay Description:Binding affinity to CLK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50512318(CHEMBL4546504)
Affinity DataIC50: 0.261nMAssay Description:Inhibition of recombinant human GST-tagged CLK2 catalytic domain (137 to 498 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM15138(Biochemistry 469551 Compound 11 | 5-indazolyl pyri...)
Affinity DataKd:  0.510nMAssay Description:Binding constant for CLK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of human CLK2 incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50613087(CHEMBL5091238)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of N-terminal FLAG-tagged human CLK2 using ULight MBP peptide as substrate incubated for 10 mins in presence of 20 uM ATP incubated for 45...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50609269(CHEMBL5269810)
Affinity DataIC50: 0.822nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM445772(US10669240, Compound 69 | US10669240, Compound 68)
Affinity DataIC50: 0.822nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50581211(CHEMBL5093650)
Affinity DataKd:  0.900nMAssay Description:Inhibition of human partial length CLK2 (D144/R498) expressed in bacterial system by DiscoveryX Kinomescan binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50627496(CHEMBL5409574)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CLK2 using GSK3(14-27) peptide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50627485(CHEMBL5400230)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CLK2 using GSK3(14-27) peptide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50566490(CHEMBL4848224)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human CLK2 incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589393(CHEMBL5202010)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50639265(CHEMBL5561941)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of CLK2 (unknown origin) incubated for 10 mins in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM317482(US9623028, Compound 349 | 4-(4-((1s,4s)-4-hydroxy-...)
Affinity DataIC50: 1.43nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50566492(CHEMBL4872225)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human CLK2 incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50566489(CHEMBL4848072)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human CLK2 incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM317465(US9623028, Compound 79 | 4-(4-(cyclopentyloxy)-5-(...)
Affinity DataIC50: 1.91nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50627505(CHEMBL5429404)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CLK2 using GSK3(14-27) peptide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50627394(CHEMBL5438293)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CLK2 using GSK3(14-27) peptide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CLK2 (unknown origin) by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50627396(CHEMBL5404416)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CLK2 using GSK3(14-27) peptide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50627495(CHEMBL5418722)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CLK2 using GSK3(14-27) peptide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CLK2 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM317483(US9623028, Compound 421 | 3-chloro-N-methyl-4-(5-(...)
Affinity DataIC50: 2.10nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50609268(CHEMBL5286791)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50632896(CHEMBL5434183)
Affinity DataKd:  2.10nMAssay Description:Binding affinity to CLK2 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM317471(US9623028, Compound 134 | (S)-3-chloro-N-methyl-4-...)
Affinity DataIC50: 2.27nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM317469(US9623028, Compound 118 | 3-methoxy-4-(4-methoxy-5...)
Affinity DataIC50: 2.29nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM317475(US9623028, Compound 171 | 3-cyano-N-methyl-4-(5-(2...)
Affinity DataIC50: 2.32nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50566488(CHEMBL4875513)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human CLK2 incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50609267(CHEMBL5283453)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50592247(CHEMBL5200367)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human recombinant GST-tagged Clk2 expressed in Baculovirus expression system using GRSRSRSRSRSRSRSR peptide as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human CLK2 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50627506(CHEMBL5404544)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CLK2 using GSK3(14-27) peptide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50627397(CHEMBL5420645)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CLK2 using GSK3(14-27) peptide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50627494(CHEMBL5422654)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CLK2 using GSK3(14-27) peptide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM317485(US9623028, Compound 423 | 3-chloro-N-methyl-4-(5-(...)
Affinity DataIC50: 3.29nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM317468(US9623028, Compound 101 | 4-(4-(cyclopentyloxy)-5-...)
Affinity DataIC50: 3.38nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM317467(US9623028, Compound 90 | 3-methoxy-N-methyl-4-(5-(...)
Affinity DataIC50: 3.5nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50639252(CHEMBL5560595)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of CLK2 (unknown origin) incubated for 10 mins in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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