Compile Data Set for Download or QSAR
Report error Found 21 of affinity data for UniProtKB/TrEMBL: P77488
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50488581(BDBM50496737 | SODIUM METHYL ACETYLPHOSPHONATE)
Affinity DataKi:  960nMAssay Description:Competitive inhibition of ThDP-dependent Escherichia coli DXP synthase using pyruvate as substrate assessed as NADPH consumption by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50641841(CHEMBL5571246)
Affinity DataKi:  5.10E+3nMAssay Description:Uncompetitive inhibition of Escherichia coli DXPS assessed as inhibition constant in presence of fixed concentration of GAP and varying concentration...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50496738(CHEMBL3220785)
Affinity DataKi:  5.60E+3nMAssay Description:Competitive inhibition of ThDP-dependent Escherichia coli DXP synthase using pyruvate as substrate assessed as NADPH consumption by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50026349(KETOCLOMAZONE)
Affinity DataKi:  5.80E+3nMAssay Description:Mixed non-competitive inhibition of Escherichia coli DXPS assessed as inhibition constant in presence of fixed concentration of pyruvate and varying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50496736(CHEMBL3220784)
Affinity DataKi:  6.70E+3nMAssay Description:Competitive inhibition of ThDP-dependent Escherichia coli DXP synthase using pyruvate as substrate assessed as NADPH consumption by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50641841(CHEMBL5571246)
Affinity DataKi:  9.00E+3nMAssay Description:Uncompetitive inhibition of Escherichia coli DXPS assessed as inhibition constant in presence of fixed concentration of pyruvate and varying concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50026349(KETOCLOMAZONE)
Affinity DataKi:  7.50E+4nMAssay Description:Inhibition of Escherichia coli DXPS assessed as inhibition constant in presence of pyruvateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50026349(KETOCLOMAZONE)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of his-tagged recombinant Escherichia coli W3110 DXPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50026349(KETOCLOMAZONE)
Affinity DataKi:  8.36E+4nMAssay Description:Uncompetitive inhibition of Escherichia coli DXPS assessed as inhibition constant in presence of fixed concentration of GAP and varying concentration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50065935(NOB | CHEMBL98797 | Nitrosobenzene (Substrate 1) |...)
Affinity DataIC50: 2.08E+5nMpH: 8.0 T: 2°CAssay Description:Reaction mixtures containing HEPES (100mM, pH 8.0, 2mM MgCl2, 5mM NaCl), ThDP (1mM), BSA (1mg/mL), DMSO (10%, v/v), ᴅ-GAP (30µM), pyruvate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50026349(KETOCLOMAZONE)
Affinity DataKi:  2.20E+5nMAssay Description:Inhibition of Escherichia coli DXPS assessed as inhibition constant in presence of GAPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50496741(CHEMBL3220786)
Affinity DataKi:  2.58E+5nMAssay Description:Competitive inhibition of ThDP-dependent Escherichia coli DXP synthase using pyruvate as substrate assessed as NADPH consumption by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM108226(1‐methyl‐2‐nitrosobenzene (Subst...)
Affinity DataIC50: 2.91E+5nMpH: 8.0 T: 2°CAssay Description:Reaction mixtures containing HEPES (100mM, pH 8.0, 2mM MgCl2, 5mM NaCl), ThDP (1mM), BSA (1mg/mL), DMSO (10%, v/v), ᴅ-GAP (30µM), pyruvate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM108230(6‐hydroxy‐5‐nitrosonaphthalene&#...)
Affinity DataIC50: 3.54E+5nMpH: 8.0 T: 2°CAssay Description:Reaction mixtures containing HEPES (100mM, pH 8.0, 2mM MgCl2, 5mM NaCl), ThDP (1mM), BSA (1mg/mL), DMSO (10%, v/v), ᴅ-GAP (30µM), pyruvate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM108228(1‐nitroso‐2‐naphthol (Substrate ...)
Affinity DataKi:  4.22E+5nM ΔG°:  -20.0kJ/mole IC50: 1.07E+6nMpH: 8.0 T: 2°CAssay Description:Reaction mixtures containing HEPES (100mM, pH 8.0, 2mM MgCl2, 5mM NaCl), ThDP (1mM), BSA (1mg/mL), DMSO (10%, v/v), ᴅ-GAP (30µM), pyruvate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM108229(6‐bromo‐1‐nitrosonaphthalen̴...)
Affinity DataIC50: 5.22E+5nMpH: 8.0 T: 2°CAssay Description:Reaction mixtures containing HEPES (100mM, pH 8.0, 2mM MgCl2, 5mM NaCl), ThDP (1mM), BSA (1mg/mL), DMSO (10%, v/v), ᴅ-GAP (30µM), pyruvate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM108227(NDMA (Substrate 4))
Affinity DataIC50: 8.44E+5nMpH: 8.0 T: 2°CAssay Description:Reaction mixtures containing HEPES (100mM, pH 8.0, 2mM MgCl2, 5mM NaCl), ThDP (1mM), BSA (1mg/mL), DMSO (10%, v/v), ᴅ-GAP (30µM), pyruvate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50496740(CHEMBL3220788)
Affinity DataKi: >1.00E+6nMAssay Description:Competitive inhibition of ThDP-dependent Escherichia coli DXP synthase using pyruvate as substrate assessed as NADPH consumption by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50496739(CHEMBL3220787)
Affinity DataKi: >1.00E+6nMAssay Description:Competitive inhibition of ThDP-dependent Escherichia coli DXP synthase using pyruvate as substrate assessed as NADPH consumption by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM108232(1‐isopropyl‐3,5‐dimethyl‐4...)
Affinity DataIC50: 2.00E+6nMpH: 8.0 T: 2°CAssay Description:Reaction mixtures containing HEPES (100mM, pH 8.0, 2mM MgCl2, 5mM NaCl), ThDP (1mM), BSA (1mg/mL), DMSO (10%, v/v), ᴅ-GAP (30µM), pyruvate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
Target1-deoxy-D-xylulose-5-phosphate synthase(Escherichia coli (strain K12))
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM108231(7‐methoxy‐1‐nitrosonaphthalen...)
Affinity DataIC50: 2.00E+6nMpH: 8.0 T: 2°CAssay Description:Reaction mixtures containing HEPES (100mM, pH 8.0, 2mM MgCl2, 5mM NaCl), ThDP (1mM), BSA (1mg/mL), DMSO (10%, v/v), ᴅ-GAP (30µM), pyruvate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed