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TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  7.80E+3nMAssay Description:Binding affinity to ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  56nMAssay Description:Binding affinity to ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.280nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  56nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  7.80E+3nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataEC50:  790nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319014(4-(3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319015(4-(3-methyl-5-phenylbenzo[b]thiophen-2-yl)pyrimidi...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319016(4-(5-benzyl-3-methylbenzo[b]thiophen-2-yl)pyrimidi...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319017(4-(5-(2-methoxybenzyl)-3-methylbenzo[b]thiophen-2-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319018(4-(5-(3-methoxybenzyl)-3-methylbenzo[b]thiophen-2-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319019(4-(5-(4-methoxybenzyl)-3-methylbenzo[b]thiophen-2-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319020(4-(3-methyl-5-(3-(trifluoromethyl)benzyl)benzo[b]t...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319021(3-((2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thio...)
Affinity DataEC50:  2.90E+3nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319022(3-((2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thio...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319023(methyl 3-((2-(2-aminopyrimidin-4-yl)-3-methylbenzo...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319024(3-(2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiop...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319025(3-(2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiop...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319026((+/-)-4-(5-(amino(3-methoxyphenyl)methyl)-3-methyl...)
Affinity DataEC50:  3.60E+3nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319027((+/-)-3-(amino(2-(2-aminopyrimidin-4-yl)-3-methylb...)
Affinity DataEC50:  900nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319028((+/-)--4-(5-(amino(4-methoxyphenyl)methyl)-3-methy...)
Affinity DataEC50:  2.60E+3nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319029((+/-)--4-(5-(amino(3-chlorophenyl)methyl)-3-methyl...)
Affinity DataEC50:  2.70E+3nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319030((+/-)--4-(5-(amino(m-tolyl)methyl)-3-methylbenzo[b...)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319031((+/-)-4-(5-(amino(phenyl)methyl)-3-methylbenzo[b]t...)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319032(4-(5-(aminomethyl)-3-methylbenzo[b]thiophen-2-yl)p...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319033((+/-)-4-(5-(1-aminoethyl)-3-methylbenzo[b]thiophen...)
Affinity DataEC50:  4.20E+3nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319034((+/-)-4-(5-(1-aminopropyl)-3-methylbenzo[b]thiophe...)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319035((+/-)-4-(5-(1-aminobutyl)-3-methylbenzo[b]thiophen...)
Affinity DataEC50:  600nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319036((+/-)-4-(5-(1-amino-2-methylpropyl)-3-methylbenzo[...)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50319037((+/-)-4-(5-(1-amino-3-methylbutyl)-3-methylbenzo[b...)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  460nMAssay Description:Binding affinity to ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326054(CHEMBL1240703)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  2.10E+3nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM26300(cid_16007391 | 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)a...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  1.50E+3nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  300nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355495(CHEMBL1908391)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  3.70E+3nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  590nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd:  470nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM27817(2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355500(CHEMBL1908394 | US9695172, GSK461364)
Affinity DataKd:  4.90E+3nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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