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TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622583(CHEMBL5413450)
Affinity DataEC50:  0.0500nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622574(CHEMBL5413099)
Affinity DataEC50: <0.100nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622567(CHEMBL5406029)
Affinity DataEC50:  0.200nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622570(CHEMBL5409708)
Affinity DataEC50:  0.200nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622569(CHEMBL5426454)
Affinity DataEC50:  0.200nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622572(CHEMBL5437022)
Affinity DataEC50:  0.200nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622576(CHEMBL5405858)
Affinity DataEC50:  0.200nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataKd:  0.230nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622581(CHEMBL5402691)
Affinity DataEC50:  0.300nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50151661(CHEMBL3752296)
Affinity DataKd:  0.390nMAssay Description:Binding affinity to CREBBP (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622565(CHEMBL5439670)
Affinity DataEC50:  0.600nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622571(CHEMBL5395475)
Affinity DataEC50:  0.600nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM662966(US20240109879, Compound 2B)
Affinity DataIC50: 0.670nMAssay Description:Reagent:Reaction buffer: 25 mM HEPES, pH 7.5, 25 mM NaCl, 0.025% CHAPS, 0.025% BSA, 0.5% DMSO.Ligand:Histone H4 (1-21) K5/8/12/16Ac-GG-Biotin.Standar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM662967(US20240109879, Compound 3B)
Affinity DataIC50: 0.670nMAssay Description:Reagent:Reaction buffer: 25 mM HEPES, pH 7.5, 25 mM NaCl, 0.025% CHAPS, 0.025% BSA, 0.5% DMSO.Ligand:Histone H4 (1-21) K5/8/12/16Ac-GG-Biotin.Standar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM537094(US11247989, Example 92)
Affinity DataIC50: 0.760nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453957(CHEMBL4217213)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50269847(CHEMBL4097025)
Affinity DataKd:  0.900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM537100(US11247989, Example 93)
Affinity DataIC50: 0.910nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50269847(CHEMBL4097025)
Affinity DataIC50: 0.940nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM536872(1-(1-acetylpiperidin-4-yl)-N-methyl-3-(3-(2-methyl...)
Affinity DataIC50: 0.970nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataIC50: 0.997nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622582(CHEMBL5397398)
Affinity DataEC50:  1nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)
Affinity DataKd: <1nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM340748(US9763922, Example 274)
Affinity DataIC50: 1nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511377(3-(4,4- difluorocyclohexyl)-N- methyl-1-(2-(1-meth...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM340734(US9763922, Example 260 | 3-[5-(difluoromethyl)-2-f...)
Affinity DataIC50: 1nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511390(US11058688, Example 89 | US11058688, Example 95 | ...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50269848(CHEMBL4069831)
Affinity DataIC50: 1nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511316(3-Cyclopropyl-N-methyl-1-(3-(6-(methylcarbamoyl)py...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511394(US11058688, Example 93 | 3-(4,4- difluorocyclohexy...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50269857(CHEMBL4088793)
Affinity DataIC50: 1nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622564(CHEMBL5438596)
Affinity DataEC50:  1nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM537101(US11247989, Example 94)
Affinity DataIC50: 1nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511322(3-Cyclopropyl-N-methyl-1-(3-(2-methylthiazol-5-yl)...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511356(N-methyl-1-(3-(6- (methylcarbamoyl)pyridin- 3-yl)i...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 1nMAssay Description:Inhibition of CBP (unknown origin) biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr in presence of acetyl-coA by AlphaLISA ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM536819(3-(6-(difluoromethyl)-7-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 1.07nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50269849(CHEMBL4076748)
Affinity DataKd:  1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622573(CHEMBL5419387)
Affinity DataEC50:  1.10nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50269849(CHEMBL4076748)
Affinity DataIC50: 1.10nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM537087(US11247989, Example 90)
Affinity DataIC50: 1.10nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM536735(US11247989, Example 9)
Affinity DataIC50: 1.13nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM536741(US11247989, Example 10)
Affinity DataIC50: 1.15nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataIC50: 1.16nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM537088(US11247989, Example 91)
Affinity DataIC50: 1.17nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50269855(CHEMBL4061161)
Affinity DataIC50: 1.20nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50269856(CHEMBL4060566)
Affinity DataIC50: 1.20nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50622562(CHEMBL5412027)
Affinity DataEC50:  1.20nMAssay Description:Induction of CBP degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
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