Compile Data Set for Download or QSAR
Report error Found 399 of affinity data for UniProtKB/TrEMBL: Q9JI35
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50215536(CHEBI:73337 | (R)-Alpha-Methylhistamine | CHEMBL26...)
Affinity DataKi:  0.0851nMAssay Description:Binding affinity towards histamine H3 receptor using [3H](R)-alpha-methylhistamine as radioligand in guinea pig cortical homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2018
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50121205(CHEBI:18295 | Histamine)
Affinity DataKi:  0.145nMAssay Description:Binding affinity towards histamine H3 receptor using [3H](R)-alpha-methylhistamine as radioligand in guinea pig cortical homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2018
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325449(1-(2-(piperidin-1-yl)ethyl)-3-(1-(1-(pyridin-4-ylm...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50215536(CHEBI:73337 | (R)-Alpha-Methylhistamine | CHEMBL26...)
Affinity DataKi:  0.151nMAssay Description:Binding affinity towards histamine H3 receptor using [3H](R)-alpha-methylhistamine as radioligand in guinea pig ileum LMMP homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2018
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM22541(VUF 9153 | N''-[(4-chlorophenyl)methyl]{[3-(1H-imi...)
Affinity DataKd:  0.158nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50247053(Tiprolisant | 1-(3-(3-(4-chlorophenyl)propoxy)prop...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of Guinea Pig Ileum H3RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50247053(Tiprolisant | 1-(3-(3-(4-chlorophenyl)propoxy)prop...)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50247053(Tiprolisant | 1-(3-(3-(4-chlorophenyl)propoxy)prop...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of Guinea Pig Ileum H3RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325450(1-(2-(dimethylamino)ethyl)-3-(1-(1-(pyridin-4-ylme...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50175828(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325466(1-(3-(dimethylamino)propyl)-3-(1-(1-(pyridin-4-ylm...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325465(1-benzyl-3-(1-(1-(pyridin-4-ylmethyl)piperidine-4-...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50175843(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM22541(VUF 9153 | N''-[(4-chlorophenyl)methyl]{[3-(1H-imi...)
Affinity DataKi:  0.220nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325460(1-(4-methoxybenzyl)-3-(1-(1-(pyridin-4-ylmethyl)pi...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325461(1-(3-methoxybenzyl)-3-(1-(1-(pyridin-4-ylmethyl)pi...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325473(1-isobutyl-3-(1-(1-(pyridin-4-ylmethyl)piperidine-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM22542(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50175833(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325448(1-(2-morpholinoethyl)-3-(1-(1-(pyridin-4-ylmethyl)...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50441652(CHEMBL2437433)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50158595((4'-(3-((2R,5R)-2,5-dimethylpyrrolidin-1-yl)propox...)
Affinity DataKi:  0.550nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50441649(CHEMBL2437416)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  0.630nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325469(1-(2-isopropoxyethyl)-3-(1-(1-(pyridin-4-ylmethyl)...)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50441646(CHEMBL2437421)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50283867(N-Cyclohexylmethyl-N'-[3-(1H-imidazol-4-yl)-propyl...)
Affinity DataKi:  0.740nMAssay Description:Antagonistic activity for Histamine H3 receptor binding in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50283867(N-Cyclohexylmethyl-N'-[3-(1H-imidazol-4-yl)-propyl...)
Affinity DataKi:  0.794nMAssay Description:Antagonistic activity for Histamine H3 receptor on electrically evoked guinea-pig ileum contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325467(1-(3-ethoxypropyl)-3-(1-(1-(pyridin-4-ylmethyl)pip...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50034711((1R,2S)-2-(1H-Imidazol-4-yl)-1-methyl-propylamine ...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325462(1-(4-chlorobenzyl)-3-(1-(1-(pyridin-4-ylmethyl)pip...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50325472(1-(2-hydroxyethyl)-3-(1-(1-(pyridin-4-ylmethyl)pip...)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50441637(CHEMBL2437430)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50128889(3-(4-Chloro-phenyl)-N-[2-(1H-imidazol-4-yl)-ethyl]...)
Affinity DataKi:  1nMAssay Description:Binding affinity against H3 receptor in guinea pig brain using [3H]N-alpha-methyl histamine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50215541(CHEMBL299589)
Affinity DataKi:  1nMAssay Description:Binding affinity towards histamine H3 receptor using [3H](R)-alpha-methylhistamine as radioligand in guinea pig cortical homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2018
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50128886(N-[4-(1H-Imidazol-4-yl)-butyl]-3,3-di-pyridin-2-yl...)
Affinity DataKi:  1nMAssay Description:Binding affinity against H3 receptor in guinea pig brain using [3H]N-alpha-methyl histamine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50118159(Dicyclopropylmethyl-carbamic acid 3-(1H-imidazol-4...)
Affinity DataKd:  1nMAssay Description:Receptor profile was evaluated at Histamine H3 receptor of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50128887(3-(4-Chloro-phenyl)-N-[4-(1H-imidazol-4-yl)-butyl]...)
Affinity DataKi:  1nMAssay Description:Binding affinity against H3 receptor in guinea pig brain using [3H]N-alpha-methyl histamine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50177543(1-(3-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from guinea pig histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50071491(4-(1H-Imidazol-4-yl)-butyramidine | SK-91606 | SK&...)
Affinity DataIC50: 1.10nMAssay Description:Histamine H3 receptor agonist activity was assessed by the inhibition of the electrically evoked twitch response of the guinea-pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50071491(4-(1H-Imidazol-4-yl)-butyramidine | SK-91606 | SK&...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of N-alpha-methylhistamine binding to histamine H3 receptor of guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50411494(CHEMBL429458)
Affinity DataKd:  1.26nMAssay Description:Antagonist activity at histamine H3 receptor in guinea pig ileum assessed as inhibition of (R)-methyl histamine induced longitudinal smooth muscle co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM85830(VUF5202)
Affinity DataKd:  1.26nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKd:  1.26nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50441644(CHEMBL2437423)
Affinity DataKd:  1.30nMAssay Description:Antagonist activity at histamine H3 receptor in electrically stimulated guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50441642(CHEMBL2437425)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity of compound towards Histamine H3 receptor was determined in guinea pig brain tissue using [3H]- N alpha-methylhistamine radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50441647(CHEMBL2437420)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50247053(Tiprolisant | 1-(3-(3-(4-chlorophenyl)propoxy)prop...)
Affinity DataEC50:  1.5nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
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