38 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation.
Columbia University
Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility.
Columbia University
Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease.
Columbia University
Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.
Columbia University
Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.
Columbia University
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.
Columbia University
Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.
Columbia University
Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase.
Columbia University
Synthesis and in vivo evaluation of [11C]MPTQ: a potential PET tracer for alpha2A-adrenergic receptors.
Columbia University
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
Columbia University
Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.
Columbia University
Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation.
Columbia University
Two new prenylated 3-benzoxepin derivatives as cyclooxygenase inhibitors from Perilla frutescens var. acuta.
Columbia University
Optimizing metabolic stability of phosphodiesterase 5 inhibitors: Discovery of a potent N-(pyridin-3-ylmethyl)quinoline derivative targeting synaptic plasticity.
Columbia University
Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists.
Columbia University
Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation.
Columbia University
Structural Elucidation of a Small Molecule Inhibitor of Protein Disulfide Isomerase.
Columbia University
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Columbia University
Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease.
Columbia University
FOUR-MEMBERED FUSED RING COMPOUND AND PREPARATION METHOD AND USE THEREOF
Jiangsu Hansoh Pharmaceutical Group
ANTIVIRAL APPLICATION OF NUCLEOSIDE ANALOG OR COMBINATION FORMULATION CONTAINING NUCLEOSIDE ANALOG
Shanghai Institute of Materia Medica
Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor
Hangzhou Innogate Pharma
Combinations comprising substituted imidazo[1,5-α]pyrazinones as PDE1 inhibitors
H. Lundbeck
Substituted pyrrolidines as G-protein coupled receptor 43 agonists
Epics Therapeutics
4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors
Qilu Pharmaceutical