52 articles for thisTarget
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Discovery of new Syk inhibitors through structure-based virtual screening.
Second Military Medical University
Structure-based optimization leads to the discovery of NSC765844, a highly potent, less toxic and orally efficacious dual PI3K/mTOR inhibitor.
Second Military Medical University
Structural modification of luteolin from Flos Chrysanthemi leads to increased tumor cell growth inhibitory activity.
Second Military Medical University
Discovery of benzenesulfonamide derivatives as potent PI3K/mTOR dual inhibitors with in vivo efficacies against hepatocellular carcinoma.
Second Military Medical University
Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase.
Second Military Medical University
Quantum chemistry calculation-aided structural optimization of combretastatin A-4-like tubulin polymerization inhibitors: improved stability and biological activity.
Second Military Medical University
Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation.
Second Military Medical University
Design and synthesis of phenylisoxazole derivatives as novel human acrosin inhibitors.
Second Military Medical University
Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy.
Second Military Medical University
Synthesis and acrosin inhibitory activities of 5-phenyl-1H-pyrazole-3-carboxylic acid amide derivatives.
Second Military Medical University
Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).
Second Military Medical University
Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping.
Second Military Medical University
Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H-benzo[d]imidazol-2-yl carbamate derivatives.
Second Military Medical University
Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
Second Military Medical University
Synthesis and acrosin inhibitory activity of substituted 4-amino-N-(diaminomethylene) benzenesulfonamide derivatives.
Second Military Medical University
Synthesis and acrosin inhibitory activities of substituted ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives.
Second Military Medical University
Discovery of novel xanthone derivatives as xanthine oxidase inhibitors.
Second Military Medical University
Hippolides A-H, acyclic manoalide derivatives from the marine sponge Hippospongia lachne.
Second Military Medical University
3D-QSAR and molecular docking studies on benzothiazole derivatives as Candida albicans N-myristoyltransferase inhibitors.
Second Military Medical University
BET-HDAC Dual Inhibitors for Combinational Treatment of Breast Cancer and Concurrent Candidiasis.
Second Military Medical University
Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer.
Second Military Medical University
Natural occurrence, bioactivity, and biosynthesis of triene-ansamycins.
Second Military Medical University
Homobivalent, Trivalent, and Covalent PROTACs: Emerging Strategies for Protein Degradation.
Second Military Medical University
Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT).
Second Military Medical University
Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans.
Second Military Medical University
Nucleic-Acid-Based Targeted Degradation in Drug Discovery.
Second Military Medical University
Evodiamine-Inspired Topoisomerase-Histone Deacetylase Dual Inhibitors: Novel Orally Active Antitumor Agents for Leukemia Therapy.
Second Military Medical University
Hydrophobic Tagging-Induced Degradation of PDEδ in Colon Cancer Cells.
Second Military Medical University
Stapled Peptides Targeting SARS-CoV-2 Spike Protein HR1 Inhibit the Fusion of Virus to Its Cell Receptor.
Second Military Medical University
Novel dual-mode antitumor chlorin-based derivatives as potent photosensitizers and histone deacetylase inhibitors for photodynamic therapy and chemotherapy.
Second Military Medical University
Discovery of Venturicidin Congeners and Identification of the Biosynthetic Gene Cluster from
Second Military Medical University
A theranostic probe of indoleamine 2,3-dioxygenase 1 (IDO1) for small molecule cancer immunotherapy.
Second Military Medical University
The discovery of novel small molecule allosteric activators of aldehyde dehydrogenase 2.
Second Military Medical University
Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis.
Second Military Medical University
Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer.
Second Military Medical University
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy.
Second Military Medical University
Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer.
Second Military Medical University
Synthesis and biological evaluation of 7-methoxy-1-(3,4,5-trimethoxyphenyl)-4,5-dihydro-2H-benzo[e]indazoles as new colchicine site inhibitors.
Second Military Medical University
Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.
Second Military Medical University
Nicotinamide Phosphoribosyltransferase (NAMPT) Is a New Target of Antitumor Agent Chidamide.
Second Military Medical University
Optimization of substituted cinnamic acyl sulfonamide derivatives as tubulin polymerization inhibitors with anticancer activity.
Second Military Medical University
Synthesis and biological evaluation of 1-benzylidene-3,4-dihydronaphthalen-2-one as a new class of microtubule-targeting agents.
Second Military Medical University
Emerging New Targets for the Treatment of Resistant Fungal Infections.
Second Military Medical University
Swinhoeisterols from the South China Sea Sponge Theonella swinhoei.
Second Military Medical University
Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections.
Second Military Medical University
Structure-based development of an osteoprotegerin-like glycopeptide that blocks RANKL/RANK interactions and reduces ovariectomy-induced bone loss in mice.
Second Military Medical University
Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery.
Second Military Medical University
Discovery of Novel KRAS-PDEδ Inhibitors by Fragment-Based Drug Design.
Second Military Medical University
Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors.
Second Military Medical University
Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c fromα-Santonin Derivatives.
Second Military Medical University