39 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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A 2-methyleneoxetane analog of orlistat demonstrating inhibition of porcine pancreatic lipase.
University of Connecticut
Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.
University of Connecticut
Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic.
University of Connecticut
Acetylenic linkers in lead compounds: a study of the stability of the propargyl-linked antifolates.
University of Connecticut
Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata.
University of Connecticut
Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.
University of Connecticut
Targeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure-activity relationships.
University of Connecticut
In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.
University of Connecticut
Medulloblastoma drugs in development: Current leads, trials and drawbacks.
University of Connecticut
Analysis of 6-(2,2-Dichloroacetamido)chrysene interaction with the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.
University of Connecticut
Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.
University of Connecticut
Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity.
University of Connecticut
Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.
University of Connecticut
Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors.
University of Connecticut
Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling.
University of Connecticut
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.
University of Connecticut
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.
University of Connecticut
Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability.
University of Connecticut
Thio-sugars. IV: Design and synthesis of S-linked fucoside analogs as a new class of alpha-L-fucosidase inhibitors.
University of Connecticut
Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors.
University of Connecticut
Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.
University of Connecticut
Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.
University of Connecticut
Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.
University of Connecticut
(-)-11-Hydroxy-7'-isothiocyanato-1',1'-dimethylheptyl-delta 8-THC: a novel, high-affinity irreversible probe for the cannabinoid receptor in the brain.
University of Connecticut
(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.
University of Connecticut
Small molecule scaffolds that disrupt the Rev1-CT/RIR protein-protein interaction.
University of Connecticut
Methyllysine binding domains: Structural insight and small molecule probe development.
University of Connecticut
Tricyclic analogues, preparation method and uses thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
Evaluation of 7-hydroxy-flavones as inhibitors of oestrone and oestradiol biosynthesis.
Cardiff University