83 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors.
University of Ljubljana
Discovery of new MurA inhibitors using induced-fit simulation and docking.
University of Ljubljana
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
University of Ljubljana
Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors.
University of Ljubljana
New N-phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATPase inhibitors of DNA gyrase.
University of Ljubljana
Structural requirements of acylated Gly-l-Ala-d-Glu analogs for activation of the innate immune receptor NOD2.
University of Ljubljana
New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.
University of Ljubljana
Diethylstilbestrol-scaffold-based pregnane X receptor modulators.
University of Ljubljana
Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.
University of Ljubljana
Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site.
University of Ljubljana
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
University of Ljubljana
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.
University of Ljubljana
Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists.
University of Ljubljana
Monovalent mannose-based DC-SIGN antagonists: targeting the hydrophobic groove of the receptor.
University of Ljubljana
Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold.
University of Ljubljana
Low molecular weight dual inhibitors of factor Xa and fibrinogen binding to GPIIb/IIIa with highly overlapped pharmacophores.
University of Ljubljana
Towards dual antithrombotic compounds - balancing thrombin inhibitory and fibrinogen GPIIb/IIIa binding inhibitory activities of 2,3-dihydro-1,4-benzodioxine derivatives through regio- and stereoisomerism.
University of Ljubljana
2,3-diarylpropenoic acids as selective non-steroidal inhibitors of type-5 17ß-hydroxysteroid dehydrogenase (AKR1C3).
University of Ljubljana
Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives.
University of Ljubljana
Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis.
University of Ljubljana
ATP-binding site of bacterial enzymes as a target for antibacterial drug design.
University of Ljubljana
Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library.
University of Ljubljana
N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3.
University of Ljubljana
Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17ß-hydroxysteroid dehydrogenase type 1.
University of Ljubljana
Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents.
University of Ljubljana
Toward a novel class of antithrombotic compounds with dual function. Discovery of 1,4-benzoxazin-3(4H)-one derivatives possessing thrombin inhibitory and fibrinogen receptor antagonistic activities.
University of Ljubljana
Fluorinated dual antithrombotic compounds based on 1,4-benzoxazine scaffold.
University of Ljubljana
Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B.
University of Ljubljana
Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activities.
University of Ljubljana
New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3.
University of Ljubljana
Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB).
University of Ljubljana
3,4-Dihydro-2H-1,4-benzoxazine derivatives combining thrombin inhibitory and glycoprotein IIb/IIIa receptor antagonistic activity as a novel class of antithrombotic compounds with dual function.
University of Ljubljana
Novel potent and selective thrombin inhibitors based on a central 1,4-benzoxazin-3(4H)-one scaffold.
University of Ljubljana
Immunosuppressive effects of new thiophene-based KV1.3 inhibitors.
University of Ljubljana
New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel.
University of Ljubljana
Development of narrow-spectrum topoisomerase-targeting antibacterials against mycobacteria.
University of Ljubljana
Exploring the interaction of N-(benzothiazol-2-yl)pyrrolamide DNA gyrase inhibitors with the GyrB ATP-binding site lipophilic floor: A medicinal chemistry and QTAIM study.
University of Ljubljana
New Class of Hsp90 C-Terminal Domain Inhibitors with Anti-tumor Properties against Triple-Negative Breast Cancer.
University of Ljubljana
Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy.
University of Ljubljana
Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead.
University of Ljubljana
ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold.
University of Ljubljana
Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead.
University of Ljubljana
Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against
University of Ljubljana
New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate
University of Ljubljana
Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall.
University of Ljubljana
From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series.
University of Ljubljana
Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD.
University of Ljubljana
Discovery of Desmuramylpeptide NOD2 Agonists with Single-Digit Nanomolar Potency.
University of Ljubljana
Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
University of Ljubljana
DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathway.
University of Ljubljana
Covalently Conjugated NOD2/TLR7 Agonists Are Potent and Versatile Immune Potentiators.
University of Ljubljana
Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their
University of Ljubljana
Cinnamic acid esters as potent inhibitors of fungal 17beta-hydroxysteroid dehydrogenase--a model enzyme of the short-chain dehydrogenase/reductase superfamily.
University of Ljubljana
Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall.
University of Ljubljana
Novel thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics: optimization via modification of P1 and P3 moieties.
University of Ljubljana
Further hit optimization of 6-(trifluoromethyl)pyrimidin-2-amine based TLR8 modulators: Synthesis, biological evaluation and structure-activity relationships.
University of Ljubljana
New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.
University of Ljubljana
Selective 3-amino-2-pyridinone acetamide thrombin inhibitors incorporating weakly basic partially saturated heterobicyclic P1-arginine mimetics.
University of Ljubljana
N-alkylpiperidine carbamates as potential anti-Alzheimer's agents.
University of Ljubljana
Structural features and functional activities of benzimidazoles as NOD2 antagonists.
University of Ljubljana
Novel thrombin inhibitors incorporating non-basic partially saturated heterobicyclic P1-arginine mimetics.
University of Ljubljana
Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors.
University of Ljubljana
Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X.
University of Ljubljana
Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors.
University of Ljubljana
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.
University of Ljubljana
Identification of indole scaffold-based dual inhibitors of NOD1 and NOD2.
University of Ljubljana
Selective Toll-like receptor 7 agonists with novel chromeno[3,4-d]imidazol-4(1H)-one and 2-(trifluoromethyl)quinoline/ quinazoline-4-amine scaffolds.
University of Ljubljana
Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B.
University of Ljubljana
Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase.
University of Ljubljana
Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators.
University of Ljubljana
Novel state-dependent voltage-gated sodium channel modulators, based on marine alkaloids from Agelas sponges.
University of Ljubljana
Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.
University of Ljubljana
Cathepsin B inhibitors: Further exploration of the nitroxoline core.
University of Ljubljana
Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
University of Ljubljana
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.
University of Ljubljana
Insight into structural requirements for selective and/or dual CXCR3 and CXCR4 allosteric modulators.
University of Ljubljana
Linker-switch approach towards new ATP binding site inhibitors of DNA gyrase B.
University of Ljubljana
The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.
University of Ljubljana
Discovery of Nanomolar Desmuramylpeptide Agonists of the Innate Immune Receptor Nucleotide-Binding Oligomerization Domain-Containing Protein 2 (NOD2) Possessing Immunostimulatory Properties.
University of Ljubljana
