43 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
University of Manchester
Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.
University of Manchester
The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.
University of Manchester
Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria.
University of Manchester
Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.
University of Manchester
Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.
University of Manchester
Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening.
University of Manchester
In silico identification and biochemical characterization of novel inhibitors of NQO1.
University of Manchester
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.
University of Manchester
Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines.
University of Manchester
Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.
University of Manchester
Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.
University of Manchester
Novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2): crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones.
University of Manchester
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.
University of Manchester
Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.
University of Manchester
Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase.
University of Manchester
Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide.
University of Manchester
Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.
University of Manchester
Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.
University of Manchester
Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
University of Manchester
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.
University of Manchester
Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2).
University of Manchester
Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET
University of Manchester
Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
University of Manchester
Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.
University of Manchester
Evaluation of neomycin analogues for HIV-1 RRE RNA recognition identifies enhanced activity simplified neamine analogues.
University of Manchester
Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase.
University of Manchester
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
University of Manchester
Evaluation of analogues of furan-amidines as inhibitors of NQO2.
University of Manchester
Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo.
University of Manchester
Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1.
University of Manchester
Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1.
University of Manchester
Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1.
University of Manchester
