BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.5M data for 728K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Donate Now

To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

Advanced Search

22 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators.EBI
Pfizer
Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.EBI
Bar-Ilan University
Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators.EBI
Chinese Academy of Sciences
Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease.EBI
Cellzome
A quantitative analysis of kinase inhibitor selectivity.EBI
Ambit Biosciences
Comprehensive analysis of kinase inhibitor selectivity.EBI
Ambit Biosciences
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).EBI
Ambit Biosciences
Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.EBI
Pfizer
BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.EBI
Bristol-Myers Squibb Company
LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.EBI
Eli Lilly and Company
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.EBI
The Scripps Research Institute
Synthesis, kinase inhibition and anti-leukemic activities of diversely substituted indolopyrazolocarbazoles.EBI
University Clermont Auvergne
The mechanism of UNC-51-like kinase 1 and the applications of small molecule modulators in cancer treatment.EBI
Shenyang Pharmaceutical University
Targeting autophagy drug discovery: Targets, indications and development trends.EBI
China Jiliang University
Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors.EBI
University of Colorado Anschutz Medical Campus
Discovery of 4EBI
TBA
Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application.EBI
Takeda Pharmaceutical
Imidazolyl kinase inhibitors and uses thereofBDB
Dana-Farber Cancer Institute
Pyridinecarboxamide derivatives, preparation method thereof and pharmaceutical uses thereofBDB
Jiangsu Hengrui Medicine
Pyrazolo[3,4-c]pyridine compounds and methods of useBDB
Genetech
Diazepinone derivativesBDB
Novartis
Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2.BDB
Glaxosmithkline