BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.5M data for 728K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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22 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.EBI
Pharmakea
Combining monoamine oxidase B and semicarbazide-sensitive amine oxidase enzyme inhibition to address inflammatory disease.EBI
Pharmaxis
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.EBI
University of Manchester
Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.EBI
Pharmaxis
Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships.EBI
The Institute of Cancer Research
Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited.EBI
Hungarian Academy of Sciences
Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2).EBI
Pharmakea Therapeutics
Penicillin-binding protein inhibitorsBDB
Venatorx Pharmaceuticals
Azetidine and pyrrolidine PARP1 inhibitors and uses thereofBDB
Xinthera
Isoquinolinyl triazolone complexesBDB
Takeda Pharmaceutical
Pyrrolotriazine compounds as TAM inhibitorsBDB
Incyte
Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereofBDB
Sanford Burnham Prebys Medical Discovery Institute
Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune diseaseBDB
Guangzhou Innocare Pharma Tech
CD73 inhibitors and therapeutic uses thereofBDB
Jiangsu Hengrui Medicine
Difluoroketamide derivatives as HtrA1 inhibitorsBDB
Hoffmann-La Roche
Substituted piperidines for the treatment of cancerBDB
Les Laboratoires Servier
Inhibitors of influenza virus replication and uses thereofBDB
Sunshine Lake Pharma
Heterocyclic compounds as LSD1 inhibitorsBDB
Incyte
Pharmaceutical uses of pyridine carboxamide derivativesBDB
Jiangsu Hengrui Medicine
Tricyclic sulfones as RORγ modulatorsBDB
Bristol-Myers Squibb
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)BDB
Prelude Therapeutics