BDBM100152 7-methoxy-1-methyl-9H-beta-carboline;hydrochloride::7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride::HARMINE::Harmine hydrochloride::MLS002153910::SMR001233259::cid_5359389
SMILES COc1ccc2c(c1)[nH]c1c(C)nccc21
InChI Key InChIKey=BXNJHAXVSOCGBA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 198 hits for monomerid = 100152
TargetKallikrein-7(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human CDK2/cyclin A using histone H1 as substrate after 30 mins in presence of ATP by scintillation counting methodMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of full-length recombinant human GST-tagged Dyrk1a expressed in baculovirus expression system using Alexa-Fluor tracer-236 incubated for 6...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of human DYRK1AMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8.80nMAssay Description:Inhibition of GST-tagged human recombinant DYRK1A by FRET-based LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of DYRK1A in human HeLa cells assessed as decrease in SF3B1 phosphorylation at Thr434 after 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant full length GST-tagged DYRK1A expressed in baculovirus expression system assessed as decrease in tau phosphorylation ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of human full length DYRK1A using KKISGRLSPIMTEQ as substrate after 30 mins in presence of [gamma33P-ATP]More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of human full length DYRK2 using KKISGRLSPIMTEQ as substrate after 30 mins in presence of [gamma33P-ATP]More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human full length DYRK3 using KKISGRLSPIMTEQ as substrate after 30 mins in presence of [gamma33P-ATP]More data for this Ligand-Target Pair
Affinity DataIC50: 7.06E+3nMAssay Description:Inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as releas...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (Ac)-AMC as substrate after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using Boc-Lys (Ac)-AMC as substrate incubated for 60 mins and measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of DYRK1A (unknown origin) by FRET-based Lantha-screen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using Boc-Lys (Ac)-AMC as substrate incubated for 60 mins by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC in human HeLa nuclear extractMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Bonn
Curated by ChEMBL
University of Bonn
Curated by ChEMBL
Affinity DataIC50: 5.08E+3nMAssay Description:Inhibition of human ABCG2 expressed in MDCK2 cells assessed as reduction in pheophorbide A efflux pre-incubated for 30 mins before Hoechst 33342 addi...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Human)
Institute of Molecular and Cell Biology
Curated by ChEMBL
Institute of Molecular and Cell Biology
Curated by ChEMBL
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of protein kinase CMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Human)
Institute of Molecular and Cell Biology
Curated by ChEMBL
Institute of Molecular and Cell Biology
Curated by ChEMBL
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of Cyclin-dependent kinase 5-p35nck5aMore data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Institute of Molecular and Cell Biology
Curated by ChEMBL
Institute of Molecular and Cell Biology
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of Cyclin-dependent kinase 2-cyclin AMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Human)
Institute of Molecular and Cell Biology
Curated by ChEMBL
Institute of Molecular and Cell Biology
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of Cell division cycle 2 (CDK1)-cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Fyn kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Lyn tyrosine kinaseMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human DYRK1A using [33P]-ATP incubated for 120 minsMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
University of Oxford
Curated by ChEMBL
University of Oxford
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of human DYRK1B using [33P]-ATP incubated for 120 minsMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human DYRK1A-mediated tau phosphorylation expressed in HEK293 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Affinity DataIC50: 3.21E+4nMAssay Description:Inhibition of human full length GSK3beta expressed in baculovirus in Sf9 insect cells using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate by ADP-Glo kin...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of DYRK1A (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of MAOA (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals
Curated by ChEMBL
Rigel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST-fused full-length human DYRK1A (1 to 763 residues) expressed in baculovirus expression system using myelin basic protein...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of recombinant human MAO-A using using kynuramine as substrate assessed as inhibition of 4-hydroxyquinoline formation incubated for 20 min...More data for this Ligand-Target Pair
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Affinity DataIC50: 3.21E+4nMAssay Description:Inhibition of GSK3-beta (unknown origin) incubated for 60 mins by ATP-Glo luminescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human recombinant MAO-A assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 720nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CLK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of CLK4 (unknown origin)More data for this Ligand-Target Pair
