BDBM50323214 6-[4-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-phenoxy]-5,7-dihydroxy-2-(4-hydroxy-phenyl)-chromen-4-one::CHEMBL291426::HINOKIFLAVONE

SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)c(Oc3ccc(cc3)-c3cc(O)c4c(cc(O)cc4=O)o3)c(O)cc2o1

InChI Key InChIKey=DWXKOQIOXVVGJJ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50323214   

TargetBeta-secretase 1(Human)
Shujitsu University

Curated by ChEMBL
LigandPNGBDBM50323214(CHEMBL291426 | 6-[4-(5,7-Dihydroxy-4-oxo-4H-chrome...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BACE1 after 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50323214(CHEMBL291426 | 6-[4-(5,7-Dihydroxy-4-oxo-4H-chrome...)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of human Cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50323214(CHEMBL291426 | 6-[4-(5,7-Dihydroxy-4-oxo-4H-chrome...)
Affinity DataIC50: 7.76E+4nMAssay Description:Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50323214(CHEMBL291426 | 6-[4-(5,7-Dihydroxy-4-oxo-4H-chrome...)
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Medichem Research

Curated by ChEMBL
LigandPNGBDBM50323214(CHEMBL291426 | 6-[4-(5,7-Dihydroxy-4-oxo-4H-chrome...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of HIV1 recombinant reverse transcriptase p66/p51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Meiji Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50323214(CHEMBL291426 | 6-[4-(5,7-Dihydroxy-4-oxo-4H-chrome...)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of human amyloid beta (1 to 40) assessed as reduction in aggregation measured after 24 hrs by ThT fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGenome polyprotein(Dengue virus)
Csir-Indian Institute of Chemical Technology (CSIR-IICT)

Curated by ChEMBL
LigandPNGBDBM50323214(CHEMBL291426 | 6-[4-(5,7-Dihydroxy-4-oxo-4H-chrome...)
Affinity DataIC50: 260nMAssay Description:Inhibition of DENV C-terminal histidine-tagged NS5/RNA-dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed