BDBM50010859 CHEMBL11::IMIPRAMINE HYDROCHLORIDE::IMIPRAMINE PAMOATE::Imipramin
SMILES CN(C)CCCN1c2ccccc2CCc3c1cccc3
InChI Key InChIKey=BCGWQEUPMDMJNV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 191 hits for monomerid = 50010859
Affinity DataIC50: 0.0600nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 0.770nMAssay Description:Displacement of [3H]imipramine from human 5HT transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 0.880nMAssay Description:Displacement of [3H]imipramine from human recombinant 5HT transporter expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 0.880nMAssay Description:Displacement of [3H]imipramine from human recombinant 5-HT transporter expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 1nMAssay Description:Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK-293 cell membranes after 30 mins by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 1.70nMAssay Description:Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 2nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]imipramine from human recombinant SERT expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]imipramine from human SERT expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK293 cells membranes incubated for 30 mins by microbeta scintillation...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Norepinephrine transporter activity was determined by the ability of compound to inhibit the neurotransmitter norepinephrine-NE reuptake system using...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human SERT W103A mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 4.10nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 5nMAssay Description:Binding affinity towards Serotonin transporter using [3H]paroxetine as radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Mouse)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Binding affinity to Serotonin transporter using [3H]-paroxetine as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human SERT expressed in CHO cell membranes assessed as reduction in [3H]serotonin uptake preincubated for 10 mins followed by [3H]serot...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 5.70nMAssay Description:Inhibition of human SERT I179C mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 6.80nMAssay Description:Displacement of [3H]imipramin from human recombinant SERT over-expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human 5-HT transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 7.57nMAssay Description:Inhibition of [3H]serotonin reuptake at serotonin transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to H1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Binding affinity towards Norepinephrine transporter using [3H]nisoxitine as radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
TargetSodium-dependent noradrenaline transporter(Human)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 20nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 20nMAssay Description:Displacement of [3H]citalopram from serotonin transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 23nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Displacement of [3H]-citalopram from SERT in rat cortex tissue measured after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 29nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair

3D Structure (crystal)