BDBM18959 3-{[4-(2-aminoethoxy)-3,5-diiodophenyl]carbonyl}-2-butyl-1-benzofuran::CHEMBL1598::DDEA::Desdiethylamiodarone::Di-N-desethylamiodarone::L 33530::Methanone

SMILES CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN)c(I)c1

InChI Key InChIKey=ZOCLVGHDXBVATF-UHFFFAOYSA-N

Data  10 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 18959   

TargetThyroid hormone receptor alpha(Chicken)
University of Amsterdam

LigandPNGBDBM18959(CHEMBL1598 | Di-N-desethylamiodarone | L 33530 | 3...)
Affinity DataIC50: 3.70E+4nMpH: 7.6 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Rat)
University of Amsterdam

LigandPNGBDBM18959(CHEMBL1598 | Di-N-desethylamiodarone | L 33530 | 3...)
Affinity DataIC50: 1.90E+4nMpH: 7.6 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM18959(CHEMBL1598 | Di-N-desethylamiodarone | L 33530 | 3...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at rat TAAR1 expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM18959(CHEMBL1598 | Di-N-desethylamiodarone | L 33530 | 3...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of recombinant GST-tagged KDM5A PHD3 (1601 to 1660 residues) (unknown origin) using biotin-H3K4me3 ( 1 to 14 residues) peptide substrate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM18959(CHEMBL1598 | Di-N-desethylamiodarone | L 33530 | 3...)
Affinity DataIC50: 7.20E+4nMAssay Description:Inhibition of recombinant GST-tagged KDM4A double tudor domain (895 to 1011 residues) (unknown origin) using biotin-H3K4me3 ( 1 to 14 residues) pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetInhibitor of growth protein 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM18959(CHEMBL1598 | Di-N-desethylamiodarone | L 33530 | 3...)
Affinity DataIC50: 9.70E+4nMAssay Description:Inhibition of recombinant GST-tagged ING2 PHD (201 to 281 residues) (unknown origin) using biotin-H3K4me3 ( 1 to 14 residues) peptide substrate by fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM18959(CHEMBL1598 | Di-N-desethylamiodarone | L 33530 | 3...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of recombinant HQ5-Halo-tagged KDM5A PHD3 domain (unknown origin) measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM18959(CHEMBL1598 | Di-N-desethylamiodarone | L 33530 | 3...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of recombinant HQ5-Halo-tagged KDM4A tudor domain (unknown origin) measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM18959(CHEMBL1598 | Di-N-desethylamiodarone | L 33530 | 3...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of Halo-tagged KDM5A PHD3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM18959(CHEMBL1598 | Di-N-desethylamiodarone | L 33530 | 3...)
Affinity DataIC50: 7.20E+4nMAssay Description:Inhibition of Halo-tagged KDM4A tudor domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetInhibitor of growth protein 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM18959(CHEMBL1598 | Di-N-desethylamiodarone | L 33530 | 3...)
Affinity DataIC50: 9.70E+4nMAssay Description:Inhibition of ING2 phd domain (unknown origin )More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed