BDBM50318493 3-isopropyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate::BAY-E-9736::CHEMBL1428::NIMODIPINE::Nimotop

SMILES COCCOC(=O)C1=C(C)N=C(C)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C

InChI Key InChIKey=SVMHYHIZWOJKDL-UHFFFAOYSA-N

Data  7 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50318493   

TargetNuclear receptor subfamily 1 group I member 2(Human)
City of Hope National Medical Center

Curated by ChEMBL
LigandPNGBDBM50318493(Nimotop | 3-isopropyl 5-(2-methoxyethyl) 2,6-dimet...)
Affinity DataEC50:  390nMAssay Description:Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBile acid receptor(Human)
City of Hope National Medical Center

Curated by ChEMBL
LigandPNGBDBM50318493(Nimotop | 3-isopropyl 5-(2-methoxyethyl) 2,6-dimet...)
Affinity DataIC50: 8.96E+3nMAssay Description:Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50318493(Nimotop | 3-isopropyl 5-(2-methoxyethyl) 2,6-dimet...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318493(Nimotop | 3-isopropyl 5-(2-methoxyethyl) 2,6-dimet...)
Affinity DataKi:  0.560nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50318493(Nimotop | 3-isopropyl 5-(2-methoxyethyl) 2,6-dimet...)
Affinity DataKi:  0.790nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50318493(Nimotop | 3-isopropyl 5-(2-methoxyethyl) 2,6-dimet...)
Affinity DataKi:  2.28nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2011
Entry Details
PubMed
LigandPNGBDBM50318493(Nimotop | 3-isopropyl 5-(2-methoxyethyl) 2,6-dimet...)
Affinity DataKi:  259nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2011
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50318493(Nimotop | 3-isopropyl 5-(2-methoxyethyl) 2,6-dimet...)
Affinity DataKi:  8.47E+3nMAssay Description:Displacement of [125]AB-MECA binding to human Adenosine A3 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50318493(Nimotop | 3-isopropyl 5-(2-methoxyethyl) 2,6-dimet...)
Affinity DataKi:  2.01E+4nMAssay Description:Displacement of [3H](R)-PIA binding to Adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50318493(Nimotop | 3-isopropyl 5-(2-methoxyethyl) 2,6-dimet...)
Affinity DataKi:  4.43E+4nMAssay Description:Displacement of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed