BDBM50134036 2-(2,3-Dimethyl-phenylamino)-benzoic acid::2-(2,3-Dimethyl-phenylamino)-benzoic acid(Mefenamic acid)::2-(2,3-dimethylphenylamino)benzoic acid::CHEMBL686::CI-473::CN-35355::INF-3355::MEFENAMIC ACID::Ponstel::cid_4044::mefanamic acid

SMILES Cc1cccc(c1C)Nc2ccccc2C(=O)O

InChI Key InChIKey=HYYBABOKPJLUIN-UHFFFAOYSA-N

Data  9 KI  21 IC50  4 EC50

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50134036   

TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP K_i Database

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataKi:  160nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
3/4/2012
Entry Details Article
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TargetAldo-keto reductase family 1 member C2(Human)
University of Ljubljana

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataKi:  220nMAssay Description:Inhibition of human recombinant AKR1C2 assessed as 1-acenaphthenol oxidation by spectrophotometryMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
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TargetAldo-keto reductase family 1 member C3(Human)
University of Ljubljana

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataKi:  300nMAssay Description:Inhibition of human recombinant AKR1C3 assessed as 1-acenaphthenol oxidation by spectrophotometryMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
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TargetAldo-keto reductase family 1 member C3(Human)
University of Ljubljana

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 560nMAssay Description:Inhibition of AKR1C3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetAldo-keto reductase family 1 member C1(Human)
University of Ljubljana

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataKi:  810nMAssay Description:Inhibition of human recombinant AKR1C1 assessed as 1-acenaphthenol oxidation by spectrophotometryMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
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TargetMyeloperoxidase(Human)
Free University of Brussels

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 980nMAssay Description:Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed b...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/13/2019
Entry Details Article
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TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP K_i Database

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataKi:  1.30E+3nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
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TargetAldo-keto reductase family 1 member B10(Human)
University of Messina

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of wild-type N-terminal 6-His tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde redu...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/23/2016
Entry Details Article
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TargetProstaglandin G/H synthase 1(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP K_i Database

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataKi:  1.94E+3nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
3/4/2012
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TargetMyeloperoxidase(Human)
Free University of Brussels

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of recombinant MPO (unknown origin) assessed as reduction in LDL oxidation in presence of H2O2 and HCl after 5 mins by ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/13/2019
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TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP K_i Database

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP K_i Database

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataKi:  2.90E+3nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
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TargetAldo-keto reductase family 1 member C1(Human)
University of Ljubljana

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 3.91E+3nMAssay Description:Inhibition of AKR1C1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetAldo-keto reductase family 1 member C2(Human)
University of Ljubljana

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 6.97E+3nMAssay Description:Inhibition of AKR1C2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetProstaglandin G/H synthase 1(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP K_i Database

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
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TargetTransient receptor potential cation channel subfamily A member 1(Human)
University of Hull

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataEC50:  1.60E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetTransient receptor potential cation channel subfamily A member 1(Human)
University of Hull

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataEC50:  1.66E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetProstaglandin G/H synthase 1(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP K_i Database

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shandong University

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed C57BL/6 mouse bone marrow derived macrophages preincubated for 15 mins followed by addition...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
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TargetCytochrome P450 2J2(Human)
Tongji University

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/3/2016
Entry Details Article
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TargetBile salt export pump(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell membrane vesicles assessed as reduction in ATP or AMP-dependent [3H]-...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/19/2019
Entry Details Article
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TargetTransient receptor potential cation channel subfamily A member 1(Human)
University of Hull

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataEC50:  6.10E+4nMAssay Description:Agonist activity at human TRPA1 in WI38 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataKi:  7.20E+4nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/13/2021
Entry Details Article
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TargetAldo-keto reductase family 1 member B1(Human)
University of Messina

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 7.70E+4nMAssay Description:Inhibition of human AR by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/23/2016
Entry Details Article
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TargetAldo-keto reductase family 1 member C4(Human)
University of Auckland

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of AKR1C4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP K_i Database

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.03E+5nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
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TargetATP-binding cassette sub-family C member 3(Human)
Amgen

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/3/2019
Entry Details Article
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TargetBile salt export pump(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/3/2019
Entry Details Article
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TargetATP-binding cassette sub-family C member 4(Human)
Amgen

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/3/2019
Entry Details Article
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TargetATP-binding cassette sub-family C member 2(Human)
Amgen

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/3/2019
Entry Details Article
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TargetMalate dehydrogenase, cytoplasmic(Human)
Northwestern University

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 2.25E+5nMAssay Description:Inhibition of malate dehydrogenase (MDH)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/30/2012
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TargetGlycogen synthase kinase-3 beta(Human)
Broad Institute

Curated by PubChem BioAssay

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/29/2011
Entry Details
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TargetBeta-lactamase(Escherichia coli (strain K12))
Northwestern University

Curated by ChEMBL

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 3.50E+5nMAssay Description:Compound was tested for the inhibition of beta-lactamaseMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/30/2012
Entry Details Article
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TargetProstaglandin G/H synthase 1(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP K_i Database

LigandBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)Copy SMILESCopy InChI

Affinity DataIC50: 7.70E+5nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
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