BDBM30130 CHEMBL1201082::CHEMBL41::Fluoxetin::Fluoxetine::Prozac::US9120771, Fluoxetine::cid_62857
SMILES CNCC[C@H](c1ccccc1)Oc2ccc(cc2)C(F)(F)F
InChI Key InChIKey=RTHCYVBBDHJXIQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 263 hits for monomerid = 30130
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 3.58nMpH: 7.4Assay Description:5-HT transporter binding assay for evaluating binding of the compound to the serotonin transporter was carried out using human recombinant serotonin ...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 2.54E+3nMpH: 7.4Assay Description:NE transporter binding assay for evaluating binding of the compound to the norepinephrine transporter was carried out using human recombinant norepin...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 1.00E+4nMpH: 7.4Assay Description:DA transporter binding assay for evaluating binding of the compound to the dopamine transporter was carried out using human recombinant dopamine tran...More data for this Ligand-Target Pair
Affinity DataIC50: 1.44E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.75E+5nMAssay Description:Inhibition of CYP1B1 (unknown origin) expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 7-Ethoxyresorufin as subst...More data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+5nMAssay Description:TP_TRANSPORTER: cell accumulation of calcein in L-MDR1 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 7.20nMAssay Description:Displacement of [3H]imipramin from human recombinant SERT over-expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Binding affinity at dopamine receptor D2 by the inhibition of binding to [3H]spiperone in rat striatal membranesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of [3H]peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mouse brain AChEMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of rat synaptosome SERTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of neuronal uptake of 5 - Hydroxytryptamine in rat brain homogenateMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Institute of Science and Technology
Curated by ChEMBL
Korea Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]astemizole from human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Human)
Korea Institute of Science and Technology
Curated by ChEMBL
Korea Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 710nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor (unknown origin) by cell based radioligand competitive binding analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Human)
Korea Institute of Science and Technology
Curated by ChEMBL
Korea Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Displacement of [3H]mesulergine from 5-HT2C receptor (unknown origin) by cell based radioligand competitive binding analysisMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]imipramine from SERT receptor (unknown origin) by cell based radioligand competitive binding analysisMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 3.60nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 32.4nMAssay Description:Inhibition concentration against [3H]5-HT uptake by human serotonin transporter in JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 13nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of 5HT uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 47nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 2.5nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of SERT-mediated serotonin uptake in human JAR cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Institute of Science and Technology
Curated by ChEMBL
Korea Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Displacement of [3H] astemizole from human recombinant ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 5.20nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Affinity DataIC50: 8.30E+3nMAssay Description:Displacement of [3H]5-HT from of SERT in rat midbrain homogenates after 5 mins by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human SERT expressed in JAR cells assessed as serotonin uptakeMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataKd: 0.810nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataKd: 3.60E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataKd: 240nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Institute of Science and Technology
Curated by ChEMBL
Korea Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 39.4nMAssay Description:Inhibition of [3H]5-HT uptake at human 5-HT transporter expressed in Jar cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of [3H]NA reuptake at NA transporter in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 16nMAssay Description:Inhibition of [3H]5-HT reuptake at 5HT transporter in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of [3H]DA reuptake at DA transporter in HEK293 cellsMore data for this Ligand-Target Pair
