BDBM50001786 1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one::1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one::CHEMBL12713::Sertindole

SMILES Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2cc(Cl)ccc12

InChI Key InChIKey=GZKLJWGUPQBVJQ-UHFFFAOYSA-N

Data  141 KI  34 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 175 hits for monomerid = 50001786   

Target5-hydroxytryptamine receptor 2A(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]prozosin from human cloned 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]ketanserin (0.5 nM) from rat cerebral cortex 5-hydroxytryptamine 2A receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Golden hamster)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Golden hamster)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]prozosin from hamster cloned alpha-1b receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Golden hamster)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]prazosine from hamster alpha1B adrenoceptor expressed in Rat1 cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Bovine)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]prozosin from bovine cloned Alpha-1A receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Bovine)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]prazosin (0.3 nM) from bovine Alpha-1A adrenergic receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Bovine)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]prazosine from bovine alpha1A adrenoceptor expressed in BHK cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to dopamine D2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
University of Reading

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.380nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataIC50: 0.390nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor from rat cortical membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.390nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataIC50: 0.390nMAssay Description:Binding affinity to serotonin 5-hydroxytryptamine 2A receptors using a radioligand [3H]ketanserin binding assay in rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataIC50: 0.390nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Reading

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]spiperone (0.5 nM) from rat corpus striatum dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Reading

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Reading

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of [3H]ketanserin binding to rat 5-hydroxytryptamine 2 receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
H. Lundbeck

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.510nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
H. Lundbeck

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [3H]mesulergine (0.5 nM) from rat 5-hydroxytryptamine 2C receptor expressed in SR-3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.580nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards Serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.620nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.620nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.660nMAssay Description:Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.660nMAssay Description:Displacement of [3H]prozosin from rat cloned alpha1d receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.660nMAssay Description:Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.850nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.850nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.850nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  0.950nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
H. Lundbeck

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
H. Lundbeck

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Reading

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
H. Lundbeck

Curated by PDSP Ki Database
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
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