BDBM636720 (Peak-2) ::US11826430, Compound 1.2b

SMILES Cn1ncnc1[C@H]1[C@@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(cc1)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=NHTFNTYBBURGHS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 636720   

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636720((Peak-2) | US11826430, Compound 1.2b)
Affinity DataIC50: 50nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636720((Peak-2) | US11826430, Compound 1.2b)
Affinity DataIC50: 20nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent